Innovation in Healthcare RMATRIX Hawaii & Beyond
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1 Innovation in Healthcare RMATRIX Hawaii & Beyond RCMI Multidisciplinary And Translational Research Infrastructure EXpansion in Hawaii Jerris Hedges, PI Bruce Shiramizu & Todd Seto, Co-Program Directors January 14,
2 John A. Burns School of Medicine UNIVERSITY OF HAWAI I AT MĀNOA Established in 1965 as a 2- year program Adopted 4-year degree program in 1973 >2100 M.D. Graduates Aloha!
3 Students ~1800 applicants, 64 chosen, 90% Hawai i residents
4 Kaka ako Campus Ten acre, $150 million campus opened in 2005.
5 Research: Infectious Disease. Biosafety Level 3 laboratory on site Dengue Fever Avian Flu West Nile Virus HIV/AIDS
6 Existing Resources 3 T MR scanner ($3 million) - Office of National Drug Control Policy UH-QMC 3 T MR Research Facility (~$2 million) - Queens Medical Center
7 Institute for Biogenesis Research Founder, Dr. Ryuzo Yanagimachi Assisted fertilization Transgenesis Dr. W. Steven Ward, Principal Investigator
8 Faculty Research in the IBR Ryuzo Yanagimachi Fertility Yukiko Yamazaki PGCs and Cloning Rich Allsopp Telomerase & Stem Cells Scott Lozanoff Morphogenesis & Birth Defects Somatic Cell Cloning Stem Cells ICM TE + Primordial Germ Cell (PGC) Sperm + Egg Fertilized 2-Cell 4-Cell Egg 8-cell Blastocyst Implanted Embryo Steve Ward Sperm Chromatin Stefan Moisyadi Active Transgenesis Monika Ward Sperm Genetics and Function Vernadeth Alarcon Cell Differentiation in The Early Embryo Yusuke Marikawa Body Plan Formation
9 National Children s Study 1,000 Oahu children carefully monitored for twenty years Medical and environmental data
10 Geriatric Medicine Department Aging population Nationally-ranked programs tailored to Hawai i s diverse communities Recent FOX-AO3 discovery
11 Native Hawaiian Health Department Center for Native and Pacific Health Disparities Research diabetes heart disease asthma obesity Dr. Marjorie Mau Dr. Keawe aimoku Kaholokula
12 Cancer Research MESOTHELIOMA Dr. Michele Carbone, Landon Prize for International Collaboration Turkey
13 Some of the NIH Programs at JABSOM INBRE (Science Investigator Pipeline) CRECD (MS/PHD Clinical Research) RCRII (Clinical Research Center) CCRE (Cardiology) COBRE (Cardiology, Biogenesis, Trop Med) CCHD (Center for NHPI Health Disparities) SNRP (Neuroimaging Amphetamines/HIV)
14 Translational Research Concept Research Centers in Minority Institutions (RCMI) RCMI Clinical & Translational Research Infrastructure (RCTR) application Develop and strengthen infrastructure required for the conduct of clinical and translational research in RCMI institutions JABSOM was eligible to apply because of: Clinical Research Center (CRC), CCRE (Center of Clinical Research Excellence); Clinical Research Education and Career Development (CRECD) 14
15 Health Disparities in Hawaii Health inequities lead to health disparities in Native Hawaiians, Pacific Islanders, Asians in Hawaii: HEALTH Initiatives (Health Equity & Lifestyle Transformation in Hawaii) Cardiovascular Health Respiratory Health Cancer Health Nutrition & Metabolic Health Perinatal and Growth/Developmental Health Aging & Neurocognitive Health 15
16 Health Equity & Lifestyle Transformation in Hawaii HEALTH Initiatives 16
17 RMATRIX Key Functions 1.Collaborations and Partnerships 2.Community-Engaged Research 3.Participant and Clinical Resources 4.Multidisciplinary Research Education, Training, and Career Development 5.Biomedical Informatics 6.Research Design & Biostatistics 7.Research Ethics 8.Regulatory Knowledge & Support 9.Evaluation Milestones 17
18 RMATRIX Objectives 1.Integrated home for clinical and translational science in Hawaii 2.Consolidate, assimilate, and enhance existing infrastructure to strengthen RCMI Programs 3.Support investigators thru research education, training, and career development 4.Foster research collaborations across disciplines and throughout the communities 5.Partner in Community Engaged Research 18
19 NIH Roadmap for Medical Research: Need for Collaborations and Partnerships
20 Why Now? Why Here? National Health Plan focus on reducing health disparities within the population Why do some population subsets have more disease or worse disease? Controversy/confusion on interplay of factors influencing health Socio-economic and demographic status Genetics, ethnicity, cultural practices Access to healthcare, medicines, procedures Hawaii provides the multicultural, multiethnic community that can answer this issue 20
21 Translation to the community Telemedicine Endocrinology, Psychiatry Chronic disease management Preventive Programs Childhood obesity Hawaii
22 Next steps Personalized medicine Ethically & culturally tailored Transitions to new business models Health focused Use of alternative delivery systems Minimization of redundancy Evidence driven
23 Personalized medicine Right treatment for Right person at the Right time Why do some treatments work for some and not others? Personalized dosing and treatment combinations driven by disease understanding and individual characteristics Proteomics, genomics, epigenitics
24 Possible Direction of US Health Care ClassicCare TransitionCare FutureCare 17% GDP Resources Used ClassicCare Financial / Insurance ClassicCare Hospital / Rescue Care ClassicCare Physician Practice Medical Care = Health Care Social Care = Health Care Self // Community // Internet = Health Care Time
25 Vanishing Businesses/ Industries Travel Agencies Lehman Bros. Printing Industry Block Buster Video Local Book Stores Local Newspapers Broadcast TV Corner Bank WAMU
26 Our Potential Adventure ClassicCare TransitionCare FutureCare Resources Used Time
27 General to Molecular Newtonian to Quantum Euclidian to Fractals
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