AMERICAN SOCIETY FOR REPRODUCTIVE MEDICINE 64th Annual Meeting

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1 Page 1 of 5 Please select Print from the file menu to print your Abstract. AMERICAN SOCIETY FOR REPRODUCTIVE MEDICINE 64th Annual Meeting Filename: Submission Type: Scientific Abstract (Oral/Poster) Contact/Presenting Author: Analia Tamova, M.D., Ph.D. Department/Institution: Endocrinology and Gerontology, Medical University University Clinical Center Phone: Cell Phone: Fax: agarwaa@ccf.org Abstract Category: 28. Reproductive Endocrinology: Clinical (SREI) Abstract Topic: 23. Male Reproductive Endocrinology Poster presentation only? Are you a fellow in training in an American Board of Obstetrics and Gynecology approved program leading to certification in Reproductive Endocrinology and Infertility? Data is submitted for a separate scientific abstract and video presentation: Awards: IRB Approval: The study material in this abstract has been approved by the local Institutional Review Board (IRB) if any human subjects or any human material was utilized. ACCME Disclosure: The Accreditation Council for Continuing Medical Education (ACCME) requires full disclosure of discussion of offlabel or otherwise nonfda approved uses of a product. I will be disclosing this by:verbal Permissions Prior Publication or Presentation: The abstract contains original work, not published previously or presented at a meeting of another national or international scientific organization prior to this meeting. Six Author Rule: All authors named in this abstract have agreed to its submission for presentation at the 63rd Annual Meeting of the American Society for Reproductive Medicine and are familiar with the 6author rule. Accept Complete Responsibility: I accept complete responsibility for the data at the time of submission. Title: PHYSICAL GROWTH AND SEXUAL DEVELOPMENT IN BOYS: THE LARGEST CROSSSECTIONAL STUDY Objective: Our aim was to study parameters of physical growth and sexual development in

2 Page 2 of 5 healthy male Caucasian boys. We also studied differences in height, weight, penile length and penile circumference of the boys from rural and urban areas. Design: Population based crosssectional Materials and Methods: We examined 6200 otherwise clinically healthy Caucasian boys, aged 0 19 years from different parts of the Bulgaria. The towns and villages were chosen at random, representative of country s population and structure. In each town and village the investigator chose schools, kindergartens, and childcare centers randomly and examined children at random until he reached the required number. Each of the 20 age groups (019) had equal numbers of children (n=310 in each group) and they were included in the respective age groups according to the completed age at the day of examination. Clinical examination of all the boys was conducted by a single investigator. It included the following somatometric parameters: height (in cm), weight (in kg), testicular volume (ml), penile length (cm), penile circumference (cm), and Tanner stage according to pubic hair distribution. Results: 1. Peak period for growth of all parameters was 1213 years depicts in parameters between 12 and 13 completed years. 2. After 17 years there was no significant growth in height and weight 3. After 18 years there was no significance growth in penile length, penile circumference, and testicular volume. 4. Penile circumference of the boys investigated from the rural regions were higher (P=0.02) in comparison to the boys of urban region, while height and weight were similar (Boys at one year of age, n=310). At completion of pubertal development (at age of 19 years) height and weight of boys from urban region are higher than boys from rural region (P= 0.039; P < 0.001). However, penile length was significantly lower in urban boys (P= 0.006) Conclusions: Onset of puberty is characterized by activation of hypothalamic pituitary gonadal and somatotrophic axis. Genetic as well as environmental factors play crucial role for ethnic and regional differences in pubertal development. Various studies in last decade showed change in pubertal timings especially for girls. Longitudinal studies showed 45 years of variation in age of onset of puberty among boys due to strong genetic components. Longitudinal studies are needed to specify the trends in male sexual development, and to identify differences in development of boys from rural and urban areas. Support: ne Author: Analia Tamova, M.D., Ph.D. Department/Institution: Endocrinology and Gerontology, Medical University University Clinical Center Phone: Cell Phone: Fax: agarwaa@ccf.org

3 Page 3 of 5 source(s) and Author: Philip Kumanov, M.D., Ph.D. Department/Institution: Medical University, Sofia Phone: Cell Phone: Fax: agarwaa@ccf.org source(s) and

4 Page 4 of 5 Author: Ralitza Robeva, M.D. Department/Institution: Medical University, Sofia Phone: Cell Phone: Fax: agarwaa@ccf.org source(s) and Author: Nisarg R Desai, M.D. Department/Institution: Center for Reproductive Medicine, Cleveland Clinic City/State/Zip/Country: Cleveland, United States Phone: Cell Phone: Fax: agarwaa@ccf.org

5 Page 5 of 5 source(s) and Author: Ashok Agarwal, Ph.D. Department/Institution: Center for Reproductive Medicine, Cleveland Clinic City/State/Zip/Country: Cleveland, United States Phone: Cell Phone: Fax: agarwaa@ccf.org source(s) and Close Window

AMERICAN SOCIETY FOR REPRODUCTIVE MEDICINE 64th Annual Meeting

Page 1 of 6 Please select Print from the file menu to print your Abstract. AMERICAN SOCIETY FOR REPRODUCTIVE MEDICINE 64th Annual Meeting Filename: 650575 Submission Type: Scientific Abstract (Oral/Poster)