Hepabial + Add the missing piece to the liver s metabolism

Transcription

1 Hepabial + Add the missing piece to the liver s metabolism

2 ROLE The liver is the metabolism central laboratory in animals. Its reserve capabilities are absolutely essential in animals with high production level. Fat metabolism (Fatty acid synthesis, fat storage control) The liver Carbohydrate metabolism (blood sugar regulation) Bile secretion (helps with lipids and carbohydrates absorption) Add the missing piece to the liver s metabolism Supplementing the diet with makes it possible to overcome the energy deficiency linked to all liver dysfunctions. Better performing animals Improved ADG and FCR Optimized reproductive performances Reduction of fatty liver syndrome An original targeted formula Iron and vitamin storage Protein metabolism (Protein and urea synthesis) Diuretic* and stimulant factors Lipotropic factors** Cholagogic and choleretic*** factors CONSEQUENCES OF LIVER DYSFUNCTION Artichoke Black radish Fumitory Dandelion L-carnitine ( g/l) Transports long chain fatty acids Choline ( g/l) Allows bile to ensure fat digestion Sorbitol ( g/l) Encourages bile production and secretion Stimulates liver activity Liver toxicity Mobilisation of reserves metabolised by the liver Kidney toxicity Signs observed : Reduced appetite Drop in laying rate Reduced immune defences Reduced ADG Stress sensitivity Increased mortality To offset these different critical stages during the rearing process, it is necessary to provide support for the animal s liver and kidney functions. Stimulates appetite Encourages bile secretion Stimulates toxins elimination Allows storage / release of fats in case of high energy needs = Helps with fat digestion Improved energy metabolism Helps with fat digestion A unique combination of ingredients selected to stimulate energy metabolism and to optimize overall performances of animals. Special features of * Diuretic: substance which leads to increased urine secretion ** Lipotropic: substance which adheres to fat or facilitates its transformation *** Choleretic: substance which facilitates bile secretion, cholagogic: substance wich facilitates bile evacuation

3 Efficacy on broilers at feed change periods Efficacy on broilers at feed change periods + % net margin* for breeder - 7 % mortality TRIAL N TRIAL N + 8 % margin* thus +. / m - % mortality buildings with one-day-old broiler chicks in each one : no supplement Treated group : ml of / L of drinking water for days in every feed change periods buildings with a total of 99 one-day-old broiler chicks control buildings : no supplement treated building : ml of / L of drinking water for days in every feed change periods Effect of supplement on mortality, average daily gain and body weight (trial august 8). Effect of supplement on feed conversion ratio, mortality, average daily gain and body weight. (trial august 8) Treated group Evolution Treated group Evolution Mortality -7% FCR % ADG (g) % Mortality % Body weight (kg) % ADG (g).. -.9% Body weight (kg).. -.7% The calcultation of breeder s economic results for his two buildings shows a net margin improvement* of % with at each feed change period. * net margin = income - (feed cost + chick cost + cost + other costs) On average, supplementing broilers with at feed change periods allows to improve breeder s margin of more than 8 % thus an economic gain of. / m. * net margin = income - (feed cost + chick cost + cost)

4 Efficacy of with broilers whose feed is contaminated with mycotoxins Increased body weight gain : +,% Decreased feed conversion ration : -,7% Improved liver function ) Blood parameters (levels of liver enzymes and bile acids) Blood AST* concentration (U / L) -.9 % -.8 % -.7 % Blood ALT** concentration (U / L) % -.9 % -.77 % Blood bile acids concentration (µmol/l) + 9. % -. % - 8. % Improved immune response group broilers divided into groups Group Group Group Group Group Group Aflatoxine B e A Dosage : ml of Hepabial + /L of drinking water for the first days of life then days at each feed change period (D-D, D-D7, D9-D) ) Zootechnical performances Body weight gain (g) +. % +. % +.8 % Feed consumption (g) -. % -.87 % -.8 % group Compensastes for loss of growth caused by the mycotoxins Reduces feed consumption even with uncontaminated feed Supplementing the diet with improves the feed conversion ratio Feed conversion ratio -. % -.9 % -.87 % * AST : Aspartate Aminotransferasee ** ALT : Alanine Aminotransferasee Better liver function ) Immune response (Newcastle vaccine) Vaccination at the hatchery and on day % Antibodies titres HI* (log ) + % + % + % + % + 8 % * HI : Haemagglutination inhibition test ** Elisa : Enzyme linked immunosorbent assay Higher antibodies titres in group treated with Aids of immune response { Indicators showing hyper-solicitation of the liver D9 D % Antibodies titres ELISA** (S/P) group D9 group D + % + 9 % + % + % + 8 % supplement counteracts the negative effects of mycotoxins 7

5 Effectiveness of in laying hens Effectiveness of at 7-8 days in beef calves during the slowdown in consumption Laying curve maintained above strain standard : + % egg production during treatment period Reduction of feed consumption : -% during the period Appetite remains unchanged during product distribution Evaluating the benefits of a supplement in hens during laying test building : 9 laying hens treated. treatments Hepabial + ( to weeks apart) Dose : ml / l of drinking water for days. Treatment : W 8 / Treatment : W / Treatment : W / Treatment : W 8 Improvement in liver function - % on ASAT level (Aspartate Aminotransferase) - % on ALAT level (Alanine Aminotransferase) Improved appetite Improved digestibility calves treated ( batches) Distribution of ml of per feed per treated calf for between and 7 days. The following were noted : Calves appetite Digestibility (consistency of feaces) Blood parameters (ASAT, ALAT) Indicators showing liver pain Effects of on blood levels of hepatic enzymes 9 ASAT % laying ingested(g) Blood hepatic enzyme concentration (IU / L) 8 8, -% -% ALAT,,7, Before treatment After treatment SYSTEMATIC TREATMENTS WITH HEPABIAL+ 8 7 W W W W W9 W W W W W8 W W W W W8 W7 Batch treated Standard Feed ingested 8 Start : added to milk to improve consumption -7 day treatment At the 7-8 day period : higher concentrate in feed : calves full up 8- day treatment Isolated treatments : unexpected drop in consumption (heat) - day treatment 9

6 Effect of supplementing sows with at birth Effect of supplementing sows with L-carnitine during pregnancy and lactation + % body weight gain of piglets ( statistically significant difference) Improved reproductive performances Faster growth of piglets 8 sows in trial, divided into groups : : no supplement ( sows) Treated group : either ml of /L of drinking water during the days after birth (7 sows) or ml of /L of drinking water during days at the rd week of lactation (9 sows) The two treated groups are not differentiated because there is no statistically significant difference between them. 7 sows in trial of which gilts. All the animals are divided into groups : : no supplement Treated group : mg of L-carnitine / day / sow during pregnancy mg of L-carnitine / day / sow during lactation 8 7 Evolution of piglets average body weight (trial 8),9,77 Birth body weight Treated group 7,,8 Weaning body weight Evolution of treated group performances in comparison with control group (trial 8) Number of piglets / litter Body weight of piglets at birth Body weight of piglers at weaning Body weight gain of piglets during lactation Control group Treated group P NS NS NS * Gilts Sows Performances evolution of treated group in comparison with control group Litter weight at birth +8% +7% Piglets weight at birth +9% +% Body weight gain during lactation +% +% Differences between the control and the treated groups are more significant with gilts. Litter weight at weaning +% +% * Represents statistically significants effects : p<. NS : no significatif : p>. +% Supplementing with after birth allows to support sows appetite, a better use of feed, leading to a faster growth of piglets. A supplementation with L-carnitine during pregnancy and lactation periods improves reproductive performances of sows and allows a faster growth of piglets. Source : Ramanau A, Kluge H, Eder K, J Anim Nutr Source : Ramanau A, Kluge H, Spilke J, Eder K, J Nutr

7 The personalized solution Start Delayed growth Feed transition Heat stroke Stimulation of appetite Steatosis Stress (density, release...) laying peak Laying support Broilers X X X X X X X Turkeys X X X X Pullets X X Laying hens X X Forced-feeding ducks X X X Muscovy ducks X X X X X X Lactation preparation (before giving birth) Lactation peak (ingestion support) Feed transition Heat stroke Breeders X X X Fattening rabbits X X Weaning Lactation support Feed blockage Heat stroke Sows X X Piglets X X Fattening pigs X X Weaning Acetosis Feed blockage Heat stroke Hepatic overload after treatment Version / Fattening calves X X X X Cattle X X Instructions for use : is used diluted in drinking water. Poultry : ml / L of drinking water for to days Calves during fattening : ml / L of liquid feed for to days Other species : ml / L of drinking water for to days Biolink Limited, Halifax Way, Pocklington Ind. Est., Pocklington, York YO NR. United Kingdom. Tel: + () 79 - Fax: + () info@biolinklimited.co.uk - Web: