Information. Marie Caudill. Web Bio. Biography. Professional. Biographical Statement

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1 Marie Caudill Information Biography Web Bio Biographical Statement Dr. Marie Caudill received her PhD degree in Nutritional Sciences from the University of Florida in Shortly thereafter she became an Assistant Professor in the Department of Human Nutrition and Food Science at Cal Poly Pomona University in Southern California where she served for 10 years. Dr. Caudill joined the faculty at Cornell University as an associate professor of Nutritional Sciences and Genomics in August Dr. Caudill is internationally recognized for her work on folate and choline, and the intake levels of these nutrients required to support human health. She has published over 60 papers, reviews, or chapters in this area, and is frequently an invited speaker on topics related to methyl nutrients, one-carbon metabolism and epigenetics. In 2012, Dr. Caudill will be presenting her work at the International Conference on Advances and Controversies in B-Vitamins and Choline University of Leipzig, Germany and at the FASEB Summer Conference on Folic Acid, Vitamin B12 & One Carbon Metabolism Crete, Greece. Dr. Caudill teaches the increasingly popular upper level Nutrition and Disease course (NS 4410) which focuses on disease pathology and its intersection with nutrition. Professional Current Professional Activities Editorial Boards Journal of Nutrition, 2009 to present. Frontiers in Nutrigenomics, 2011 to present. Granting Agencies (Study Section) NIH Scientific Reviewer for the Dietary Influence on the Human Health Effects on Environmental Exposures (R21) Research Triangle Park, NC October 24-25, 2011

2 Textbook Editor Biochemical, Physiological, & Molecular Aspects of Human Nutrition Martha H. Stipanuk and Marie A. Caudill (eds.) 3rd edition. St Louis, MO: Elsevier Saunders; 2012, in press. Textbook Chapter Contributor Caudill MA, Gregory JF III, Miller J, Shane B. Folate, choline, vitamin B-12 and vitamin B-6. In: Stipanuk MH and Caudill MA. eds. Biochemical, Physiological and Molecular Aspects of Human Nutrition. 3rd edition. St Louis, MO: Elsevier Saunders; 2012, in press. Bailey LB, Caudill MA. Folate. In: Present Knowledge in Nutrition. 10 th edition. ILSI Press, Washington, DC. In Press. Yan J, Jiang X, Caudill MA. Choline. In: Zemplini J, Stover PJ, Gregory JF III, Suttie K. Handbook of Vitamins. 5 th edition. Taylor and Francis. In progress. Bailey LB, da Silva V, West AA, Caudill MA. Folate. In: Zemplini J, Stover PJ, Gregory JF III, Suttie K. Handbook of Vitamins. 5 th edition. Taylor and Francis. In progress. Davenport C, Caudill MA. Choline in human milk. In: Dietary and Nutritional Aspects of Human Breast Milk. Wageningen Academic Publishers. In progress. Research Current Research Activities The overall goal of the Caudill laboratory is to provide data that will scientifically inform the development of nutrient recommendations designed to optimize maternal and fetal health. We recently completed a long-term controlled feeding study involving nonpregnant, pregnant and lactating women and are now quantifying dose-response relationships for several nutrients including choline, folate, biotin, vitamin D, and vitamin B12. We are especially interested in the relationship between these nutrients and epigenomic/genomic marks of fetal derived tissues (i.e., placenta). In collaboration with the Roberson laboratory, we are investigating the effect of maternal choline supplementation on placental function using a mouse model of placental insufficiency. In a parallel study with the Brannon laboratory, we are investigating the effect of choline exposure on human trophoblast function in a cell culture system. These collaborations were established based on our preliminary data in pregnant women showing beneficial effects of maternal choline supplementation on placental markers of inflammation and angiogenesis. In collaboration with the laboratories of Stupp and Canfield, we are preparing a

3 grant that seeks to investigate the effect of maternal choline supplementation on offspring cognitive functioning, affect regulation, and response to stress during infancy and early childhood. Notably, our preliminary work showed that supplementing the maternal diet with extra choline diminished stress reactivity in the neonate through epigenetic mechnisms. The Caudill laboratory is also preparing a grant that seeks to assess the impact of maternal choline supplementation on insulin sensitivity and metabolic fitness among obese pregnant women. Stay tuned! Extension Education Education Doctor of Philosophy in Human Nutrition, Food Science and Human Nutrition, College of Agriculture, University of Florida Registered Dietitian, Dietetic Internship at Emory University Hospital, Atlanta, Georgia Master of Science in Health Science, College of Health, University of North Florida Bachelor of Science in Health Science, College of Health, University of North Florida Bachelor of Arts in Physical Education, College of Education, University of North Florida. Courses Courses Taught NS Micronutrients: Function, Homeostasis and Assessment Professor Caudill participates in this team taught course managed by Charles McCormick. Specifically, she delivers lectures on the B-vitamins (folate, vitamin B-12, vitamin B-6, biotin) and choline. NS Nutrition and Disease This course combines the principles of nutrition, biochemistry, physiology, genetics, pharmacology, and pathology to understand disease risk, prevention, progression and management. The course is organized in a lecture format with opportunities for the class to engage in the discussion of original research articles on topics of high current interest in the area of nutrition and health.

4 Websites Related Websites Administration Administrative Responsibilities Committee Work Faculty Search Committee, Human Metabolism, DNS Post-baccalaureate Program in Health Studies Admission Committee, DNS Graduate Admissions Committee, DNS Publications Selected Publications 2012 Caudill MA, Gregory JF III, Miller J, Shane B. Folate, choline, vitamin B-12 and vitamin B-6. In: Stipanuk MH and Caudill MA. eds. Biochemical, Physiological and Molecular Aspects of Human Nutrition. 3rd edition. St Louis, MO: Elsevier Saunders; 2012, in press Bailey LB, Caudill MA. Folate. In: Present Knowledge in Nutrition. 10 th edition. ILSI Press, Washington, DC. In Press Caudill MA, dacosta K-A, Zeisel SH, Betsy Hornick "Choline Call to Action: Elevating Awareness and Intake of an Essential Nutrient for Public Health" Nutrition Today. 46: Chew TW, Jiang X, Yan J, Wang W, Lusa AL, Carrier BJ, West AA, Malysheva OV, Brenna JT, Gregory JF III, Caudill MA. Folate intake, Mthfr genotype and sex modulate choline metabolism in mice. J Nutr. 141: Yan J, Wang W, Gregory JF III, Malysheva OV, Brenna JT, Stabler SP, Allen RH, Caudill MA. MTHFR C677T genotype influences the isotopic enrichment of one carbon metabolites in folate compromised men consuming d9-choline. Am J Clin Nutr. 93: West AA, Caudill MA* Genetic Variation: Impact on folate (and choline) bioefficacy. Int J Vitam Nutr Res. 80 (4 5), Zeisel SH, Caudill MA. Choline. Adv Nutr. 1: 46 48, doi: /an

5 2010 Shin W, Yan J, Abratte CF, Vermeylen F, and Caudill MA. Choline intake exceeding current dietary recommendations preserves markers of cellular methylation in a genetic sub-group of folate-compromised men. J Nutr.140: Chan J, Deng L, Pickell L, Wu Q, Yan J, Caudill MA, Rozen R. Low dietary choline and low dietary riboflavin during pregnancy influence reproductive outcomes and heart development in mice. Am J Clin Nutr. 91: Kathirvel E, Morgan K, Caudill MA, Nandgiri G, Sandoval BC, Bottiglieri T, French SW, Morgan TR. Betaine improves non alcoholic fatty liver and associated hepatic insulin resistance: a potential mechanism for hepatoprotection by betaine. Am J Physiol. 299:G Caudill MA. Pre- and Postnatal Health: Evidence of an Increased Choline Requirement. J Am Diet Assc. 110: Caudill MA. Folate bioavailability: Implications for establishing dietary recommendations and optimizing status. Am J Clin Nutr. 91(suppl):1455S-60S. doi: /ajcn E Christensen KE, Wu Q, Wang X, Deng L, Caudill MA, Rozen R. Steatosis in mice is associated with gender, folate intake and expression of genes of one-carbon metabolism. J Nutr. 140: Fox JT, Shin WK, Caudill MA, and Stover PJ. A UV-Responsive Internal Ribosome Entry Site Enhances Cytoplasmic Serine Hydroxymethyltransferase Expression for DNA Damage Repair. J Biol Chem. 284: Caudill MA, Dellschaft N, Solis C, Hinkis S, Ivanov AA, Nash-Barboza S, Randall KE, Jackson B, Solomita GN, Vermeylen F. Choline intake, plasma riboflavin and the PEMT G5465A genotype predict plasma homocysteine in folate deplete Mexican American men with the MTHFR 677TT genotype. J Nutr. 139: Ivanov A, Nash-Barboza S, Hinkis S, Caudill MA. Genetic variants in phosphatidylethanolamine N-methyltransferase (PEMT) and methylenetetrahydrofolate dehydrogenase (MTHFD1) influence biomarkers of choline metabolism when folate intake is restricted. J Amer Diet Assoc. 109: Abratte CM, Wang W, Li R, Axume J, Moriarty DJ, Caudill MA. Choline status is not a reliable indicator of moderate changes in dietary choline consumption in pre-menopausal women. J Nutr Biochem. 20: Veenema K, Solis C, Li R, Wang W, Maletz CV, Abratte C, Caudill MA. Choline intakes at AI levels are sufficient in preventing liver dysfunction in Mexican American men but are not optimal in minimizing plasma total homocysteine increases after a methionine load. Am J Clin Nutr. 88: Solis C, Veenema K, Ivanov AA, Tran S, Wang W, Moriarty DJ, Maletz CV, Caudill MA. Folate intake at RDA levels is inadequate for Mexican American men with the methylenetetrahydrofolate reductase 677TT genotype. J Nutr. 138: Stover PJ, Caudill MA. Genetic and Epigenetic Contributions to Human Nutrition and Health: Managing Genome-Diet Interactions. J Am Diet Assoc. 108: Hung J, Abratte CM, Wang W, Li R, Moriarty KJ, Caudill MA. Ethnicity and folate intake influence choline status in young women consuming controlled nutrient intakes. Journal of the American College of Nutrition. 27: Vakili S, Caudill MA. Personalized Nutrition: Nutritional Genomics as a Potential Tool for Targeted Medical Nutrition Therapy. Nutr Rev. 65: McCabe DC, Caudill MA. DNA methylation, genomic silencing, and links to nutrition and cancer. Nutr Rev. 63:

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