AURIA BIOBANK. Turning Hospital Biobank Data into Real-World Evidence using Artificial Intelligence Tools
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1 AURIA BIOBANK Turning Hospital Biobank Data into Real-World Evidence using Artificial Intelligence Tools Samu Kurki, PhD, Senior Data Scientist, Auria Biobank, Turku University Hospital, University of Turku, Finland 3rd Nordic RWD Conference, Helsinki, Finland
2 Auria Biobank Finland s first clinical biobank (founded in 2012), integrated with Turku University Hospital Jointly owned by University of Turku and Hospital Districts of Southwest Finland, Satakunta and Vaasa Finnish Biobank Act in 2013 Catchment population ~ people Ongoing collection of blood samples from every new consented patient >1,5 million FFPE samples and prospective collections of fresh tissue samples >160 biobank studies with pharma industry and academic researchers RWD
3 Finnish BioBanks Cooperative FINBB Founded in 2017, domicile Turku Founders Helsingin ja Uudenmaan Sairaanhoitopiirin kuntayhtymä Helsingin yliopisto Keski-Suomen Sairaanhoitopiirin kuntayhtymä Jyväskylän yliopisto Pirkanmaan Sairaanhoitopiirin kuntayhtymä Tampereen yliopisto Pohjois-Pohjanmaan Sairaanhoitopiirin kuntayhtymä Oulun yliopisto Pohjois-Savon Sairaanhoitopiirin kuntayhtymä Itä-Suomen yliopisto Varsinais-Suomen Sairaanhoitopiirin kuntayhtymä Turun yliopisto Finnish Biobanks RWD
4 Bio(data)banks for drug development RWD
5 Real-world data linked to specimens Provides the possibility to combine hospital databases (typically in electronic form from year 2004 on) with biobank specimens Longitudinal information on the course of disease, operations, response to treatments, outcome etc RWD
6 Clinical diagnoses Digital timeline of a patient Pathology specimens Oncology treatments Laboratory measurements RWD
7 Digital pathology for drug discovery + black for DNA isolation RWD
8 Biobank supporting diagnostics and treatment Major improvement in survival of CRC patients was observed in 2004, at the time of centralization of rectal cancer surgery introduction of multidisciplinary teams higher number of lymph nodes examined implementation of preoperative radiotherapy in rectal cancer the use of adjuvant chemotherapy in stage III CRC became also slightly more frequent The clinical presentation of CRC has remained essentially the same between 2001 and The observed changes have resulted in improved survival in CRC and a marked decrease of non-operable rectal cancer. Trends in presentation, treatment and survival of 1777 patients with colorectal cancer over a decade: a Biobank study. Heervä E et al. Acta Oncol Dec 23: RWD
9 Biobank supporting diagnostics and treatment Text mining hospital infections Karlsson A. XgBoost alg. no-sai alg. yes-sai rek. no-sai rek. yes-sai 6 15 Gaussian Naive Bayes alg. no-sai alg. yes-sai rek. no-sai rek. yes-sai RWD
10 Challenge of free text Majority of clinical data is not yet in structured form Mining of relevant information from among big data Modification of data in a form that is easy to analyze Important example: smoking status Not in structured form - needs to be mined from unstructured reports Only a very small part of the document is relevant for the question (smoking) RWD
11 Artificial intelligence methods The accuracy of the tool tested against an expert clinical investigator is 90% - 95%. The results are reproducible, and time spent can be hours vs. months RWD
12 Graphical UI for data curation RWD
13 Comorbidity network Visualization for hypothesis generation RWD
14 Final words Who benefits? Researchers: Unique samples with large amounts of clinical data Industry: Research innovations, new forms of collaboration Healthcare: Data-driven healthcare, clinical decision support Patients: Better healthcare, personalized treatments What is needed? Bio(data)banks and data lakes with big data Data scientists to turn data into knowledge Courage to work with the new methods (Legal framework, research funding,...) RWD
15 RWD
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