C. TlMCHALK,* D. R. FlNCO,t AND J. F. QUAST*
|
|
- Pauline Gordon
- 5 years ago
- Views:
Transcription
1 FUNDAMENTAL AND APPLIED TOXICOLOGY 36, (997) ARTICLE NO FA Evalation of Renal Fnction in Rhess Monkeys and Comparison to Beagle Dogs Following Oral Administration of the Organic Acid Triclopyr (3,5,6-Trichloro-2-pyridinyloxyacetic Acid) C. TlMCHALK,* D. R. FlNCO,t AND J. F. QUAST* *Health and Environmental Sciences, Dow Chemical Company, 803 Bilding, Midland Michigan 48674; and f Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia Received Agst, 996; accepted December 27, 996 Evalation of Renal Fnction In Rhess Monkeys and Comparison to Beagle Dogs Following Oral Administration of the Organic Acid Triclopyr (3,5,6-Trichloro-2-pyridinyloxyacetic Acid). TIM- CHALK, C, FINCO, D. R., AND QUAST, J. F. (997). Fndam. AppL ToxicoL 36, The crrent stdy evalated the effects of triclopyr (3,5,6-trichloro-2-pyridinyloxyacetic acid) on renal fnction following oral administration in the beagle dog and rhess monkey. Male rhess monkeys were orally administered triclopyr by gavage at a dose of /day, 7 days/week for 28 days, after which the dosage was increased to /day for 02 consective days. Grops of male dogs were administered either a single oral dose of 5 mg/ kg triclopyr or were fed a diet spiked with triclopyr at a dose of /day for 47 consective days. The following fnctional and clinical chemistry parameters were evalated: exogenos phenolslfonphthalein (PSP) excretion, inlin and para-aminohipprate (PAH) clearance (monkeys only), endogenos serm creatinine, and blood rea nitrogen (BUN) at mltiple time points dring the stdy. Creatinine, BUN, and inlin clearance were within the normal range from both species following triclopyr administration which indicates that repeated administration of triclopyr in the dog and monkey had no effect on glomerlar filtration rate (GFR). In monkeys, the percentage excretion of PSP and PAH appeared to increase following triclopyr administration (/day), sggesting that these weak organic acids may be competing for the same plasma protein-binding site enhancing their clearance. More importantly, these data strongly sggest that triclopyr is not competing with PSP or PAH for the active secretory site within the monkey kidney proximal tbles. In contrast, PSP clearance stdies in dogs clearly demonstrated that triclopyr administration (5 mg/kg) can significantly decrease the percentage PSP excretion even following a single dose administration. The decrease in percentage PSP was reversible and inversely related to the plasma triclopyr concentration. Overall, these data clearly indicate that triclopyr effectively competes with PSP for the active secretory site within the dog kidney proximal tbles. In contrast, the monkey was insensitive to the effects of triclopyr on the active secretory process even at doses forfold higher (/day) than the effective dose in the dog (/day). These findings sggest that the effect observed on PSP and PAH excretion in the dog represent a physiological competition for excretion and not toxicity. C 997 Society of Toxicology. Triclopyr (3,5,6-trichloro-2-pyridinyloxyacetic acid) is the active ingredient in Garlon herbicides and is sed in the control of a wide variety of broad leaf and woody plants. Triclopyr is an organic acid which has a moderate acte toxicity; oral LD50 in rats is 73 mg/kg (Worthing, 987). Sbchronic (3 week) dietary administration of mg/ kg/day of triclopyr reslted in slight degeneration of the descending proximal tbles (S3 segment) of the kidneys in rats given /day or more (Landry et al., 985). Chronic dietary administration to rats reslted in no tmorigenic response and the no-observed-effect-level (NOEL) was 3 mg triclopyr/kg/day (Eisenbrandt et al, 988). A - year chronic dietary stdy was condcted in the dog at doses of 0, 0.5, 2.5, and /day; the kidney was identified as a target organ (988, npblished report of the Dow Chemical Co., Midland, MI). The NOEL for the chronic dog stdy was 0./day. The kidney effects observed at 2.5 and /day were characterized by a slight redction in phenolslfonphthalein (PSP) excretion, slight increases in BUN and creatinine, and an increase in normally occrring pigment in the proximal tbles of the kidneys. These minor changes were interpreted to be a reversible physiological adaptation associated with excretion of the test material. Therefore, the no-observed-adverse-effect level (NOAEL) was considered to be /day, which was 0 fold greater than the observed NOEL in this same stdy. In comparison, female rhess monkeys demonstrated no treatment-related effects when administered triclopyr acid by gavage at doses of 0, 0, 20, and 30 mg/kg/day for 28 days (976, npblished report of the Dow Chemical Co.). The pharmacokinetics of triclopyr in the dog were markedly different from those in monkey, rat, or hmans (Timchalk etai, 990, 996; Carmichael etal, 989). In hmans, Trademark of DowElanco /97 $25.00 Copyright 997 by the Society of Toxicology. AUrightsof reprodction in any form reserved.
2 48 TIMCHALK, FINCO, AND QUAST an orally administered dose of 0. or 0. provided no indication of nonlinear pharmacokinetics and was rapidly eliminated with a terminal phase half-life in blood of 5-hr (Carmichael et al., 989). An intravenosly administered dose of 30 mg triclopyr/kg of body weight in a monkey was rapidly eliminated from the plasma (t\ = 6.3 hr), with >95% of the rinary I4 C radioactivity excreted within 24 hr. In contrast, the kinetics of triclopyr excretion in the dog were nonlinear with virtally all the dose excreted in the rine by 72 hr postdosing; however, the fraction excreted in the rine decreased with increasing dose (Timchalk et al., 996). Overall, the slower renal excretion in the dog was a fnction of extensive nonlinear plasma protein binding and tblar reabsorption of triclopyr. These findings were consistent with previos dog stdies with organic acids which sggested that they have a lower capacity than other species for the renal clearance of organic acids (Gehring and Betso, 978; Piper et al., 973; Hook et al, 974, 975; Cherkofsky, 995). The objective of the crrent stdy was to evalate the effects of repeated triclopyr administration on kidney fnction in the monkey, and to compare this response to that observed in the dog following single or repeated exposre. These data provide additional perspective on the relevance of the renal effects observed in the dog chronic toxicity data for hman risk extrapolation. Test Material and Dosing MATERIALS AND METHODS Technical-grade triclopyr (chemicaj prity >99.4%) was obtained from DowElanco (Indianapolis, IN). Dogs were administered the single oral 5 mg triclopyr/kg body wt dose by gavage at a volme of 2 ml/kg as an aqeos soltion. Rhess monkeys were administered triclopyr dissolved in a 0.05 M phosphate bffer (ph 7.0) which was orally administered by gavage at a volme of ml/kg body wt, at a dose of /day, 7 days/ week for 28 days, after which the dosage was increased to /day for an additional 02 days (30 daily doses). Repeated dietary administration in dogs was accomplished by placing a weighted amont of triclopyr into a gelatin capsle which was then mixed with a small amont of grond beef which the dogs were allowed to immediately eat. Dogs received a nominal dose of /day for 47 consective days. No attempt was made to determine the stability of triclopyr within the gelatin capsle/grond beef matrix. However, nmeros stdies within the laboratory have demonstrated that triclopyr is extremely stable in a variety of matrixes, sch as in the diet and as an aqeos soltion (personal commnication). Animals For male Rhess monkeys (Macaco mlatto') were selected from the colony at the International Center of Environmental Safety (Holloman Air Force Base, NM). The monkeys were hosed individally in air-conditioned qarters with feed and tap water available ad libitm throghot the stdy. Eight male beagle dogs were prchased from HRP, Inc. (Cmberland, VA) for se in the single-dose experiment and were acclimated to the laboratory environment. These dogs were hosed in otside rns except dring experimentation and had feed and water available ad libitm. However, dogs were fasted overnight preceding each day that PSP and creatinine clearance were measred. Two male beagle dogs for the repeated dietary administration were prchased from Marshall Research Animals (North Rose, NY), and were likewise acclimated to the laboratory environment. The dogs were hosed in appropriate air-conditioned qarters with feed and tap water available ad libitm throghot the stdy. All for monkeys and all dogs were administered triclopyr with an appropriate preadministration period serving as the control period. Therefore, each animal served as its own control. Single-Dose Administration (Dogs Only) Experimental design. Body weight determinations and baseline vales for PSP excretion and endogenos creatinine clearance were obtained on all dogs 23 hr prior to triclopyr administration. Triclopyr () was administered by gavage to six dogs with two dogs serving as ntreated time controls. Untreated controls did not vary from baseline for any of the parameters evalated (data not shown). PSP excretion was determined as described by Osborne et al. (972). All dogs had PSP and endogenos creatinine clearance measred repeatedly at predose and, 23, and 73 hr postdosing and all procedres were performed in an identical manner dring the for test times. Dogs were placed in Pavlov slings and were given 200 ml of water by gavage to increase rine flow rates. A venos catheter was placed in the saphenos or cephalic vein for se in blood specimen collection and a rethral cadieter was pt in place for collection of rine. Immediately after rinsing the bladder widi sterile water, a clinical test dose of PSP (6 mg/animal) was given intravenosly. Urine was then collected sing a catheter over the following 20 min; the bladder was flshed with sterile water to assre complete collection of PSP and endogenos creatinine. The amont of PSP excreted dring the 20-min interval was expressed as a percentage of the original dose of PSP. A blood specimen was taken at the midpoint of the collection interval and centrifged to obtain plasma which was analyzed for triclopyr and endogenos creatinine. Urine and bladder rinse were pooled and analyzed for creatinine and PSP. The analysis for triclopyr, creatinine, and PSP in specimens of plasma and rine was as previosly described (Carmichael et ai, 989; Finco, 97, 993). Repeated Administration Experimental design. Animals were observed daily for overt signs of toxicity or changes in demeanor and for pharmacologic or other effects. Individal body weights were obtained for the rhess monkeys prior to the initiation of daily dosing and on Days 28,52,66, and 5. Clinical chemistry parameters for the monkeys were evalated predose and following 8, 59, and 5 days of dosing, whereas for dogs, these parameters were evalated predose and on dosing Days 6 and 37. Urinalysis and PSP clearance assays were condcted for the monkeys predose and on Days 8, 24, 52, 65, 00, and 3 days of dosing and for dogs at predose and on Days 7 and 3. Monkeys and dogs were fasted overnight and a clinical test dose of PSP (6 mg/animal) was given intravenosly as previosly described. In general, the PSP excretion evalation was condcted in the morning prior to the daily administration of triclopyr. However, in one instance (Day 3, ), the dose of triclopyr was infsed intravenosly, rather than given orally, dring the 20 min period following injection of PSP in the monkey. This change in triclopyr dose administration had no impact on the reslts of this stdy. In addition to the PSP evalation, inlin and />ara-aminohipprate (PAH) clearance were evalated, in only the monkeys, sing an adaptation of the constant-infsion techniqe of Cole et al. (972), at predose and on Days 26 and 66 of dosing. Priming doses of 40 mg/kg of inlin and 8 mg/kg PAH were initially given intravenosly while a sstained infsion of inlin ( mg/ml) and PAH ( mg/ml) in physiological saline was administered by a constant-speed infsion pmp (0.7- ml/min) to maintain steady-state blood levels. Blood inlin and
3 49 TRICLOPYR EFFECTS ON RENAL FUNCTION UU ' 2 60 II CD U 0: Control PSP :\ g - a _o s \ c 73 Time h FIG.. Endogenos creatinine clearance in male beagle dogs administered a single oral dose of 5 mg triclopyr/kg of body weight dose determined at baseline,, 25, and 73 hr postdosing. The vales represent mean SD for six animals. PAH levels for clearance calclations were determined at ~ 4 hr of infsion. Inlin was measred according to the method of Heyrovsky (956). PAH was determined sing the method of Bratton and Marshall (939) as modified by Smith et al. (945)..- Time h FIG. 2. Relationship between plasma triclopyr concentration (O) and percentage PSP excretion ( ) at baseline,, 25, and 73 hr postdosing in beagle dogs administered a single oral dose of 5 mg triclopyr/kg of body weight. The vales represent means SD for six animals. The average control percentage PSP excretion was 36 5%. Vales identified as statistically different are identified with an asterisk (*) (a = 0.05). Statistical Analysis weight at a constant.5 kg, whereas the second dog increased from 2 to 2.3 kg dring the stdy (data not shown). The reslts of serm creatinine and BUN analyses for monkeys and dogs repeatedly administered triclopyr are RESULTS presented in Figs. 3 and 4. Repeated triclopyr administration, in monkeys and dogs, had no biologically meaningfl Dogs administered a single oral dose of 5 mg triclopyr/ impact on creatinine and BUN vales. The vales obtained kg body wt were clinically normal at the initiation of the in monkeys at all time periods and doses were well within stdy and remained normal throghot the trial. The mean the normal limits for the colony. In dogs, serm creatinine body weight at the stdy start was kg. Vales levels (Fig. 4A) following the treatment were for endogenos creatinine clearance (Fig. ) following this slightly elevated from baseline. However, both BUN and single-dose triclopyr administration were not statistically dif- serm creatinine were well within the reported range of ferent from baseline (control) levels. The percentage PSP normal for the beagle dog (Osborne et al., 972; Dncan excretion and triclopyr plasma concentration (/j,g ml~') fol- and Prasse, 986). lowing a single oral dose in dogs are presented in Fig. 2. PSP excretion was significantly decreased to 63 and TABLE 74% of baseline levels at and 25 hr postdosing, respecbody Weights of Monkeys Administered Triclopyr at Doses of tively. However, by 73 hr postdosing PSP excretion had retrned to near baseline levels (96%). The plasma triclopyr /day for 28 Days Followed by /day throgh 30 concentration and percentage PSP excretion were inversely Days Predose vales (baseline) were compared with vales obtained postdosing sing a paired t test (a = 0.05) (Steel and Torrie, 980). related over time. Plasma triclopyr concentration showed a decreasing trend with time, ranging from ~4 (ig/ml ( hr postdosing) to ~ fig/ml (72 hr postdosing). The monkeys and dogs tolerated the repeated administration of triclopyr at doses of 5 and /day (monkeys only) over a 30- or 4-day dosing period, respectively. Body weight changes for the monkeys are shown in Table and increased over the stdy dration. One dog maintained its Dose grop Day of dosing _ is S3 m 5 Vales represent means SD for for animals. Body wt (kg)"
4 50 TIMCHALK, FINCO, AND QUAST variability among test days, in general the response exceeded baseline measrements and in no case was PSP excretion significantly redced. On the other hand, PSP excretion in dogs was redced approximately 50% from baseline on Test Days 7 and 3 following the dose. Inlin and PAH clearance also were examined in the monkey as indicators of renal fnction following triclopyr administration (Fig. 6). Inlin clearance following oral administration of triclopyr at /day (Day 26) and / *4.5 A..2 l (. -.0) (0.9 -.).0 (day 8) (day 59) (day 5) ( ) 0.8 G l " (day 6) (day 37) 20 i (day 8) (day 59) (day 5) FIG. 3. Endogenos creatinine (A) and BUN (B) concentrations in male rhess monkeys repeatedly administered triclopyr at a dose of /day for 28 days followed by an additional 02 days at /day (30 daily doses). The vales represent means SD for for animals. Vales identified as statistically different are identified with an asterisk (*) (a = 0.05). Phenolslfonphthalein excretion in monkeys and dogs is presented in Fig. 5. In monkeys the rate of PSP excretion following 8 daily /day doses of triclopyr was slightly lower than baseline. However, a second PSP evalation at Day 24 () exceeded the baseline response. The PSP excretion was repeatedly (4 times) reevalated after increasing the daily dose of triclopyr to /day. Althogh the PSP excretion demonstrated a considerable degree of (4-23) (7-20) (day 6) (day 37) 6 FIG. 4. Endogenos creatinine (A) and BUN (B) concentrations, on dose Days 6 and 37, in male beagle dogs administered triclopyr at a dose of /day in their diet for 47 days. The vales represent mean for two animals and individal animal data are presented in parentheses. 8
5 TRTn.OPYR F.FFF.CTS ON RENAL FUNCTION A. baseline clearance, whereas the PAH clearance following 60 days of repeated triclopyr administration at a dose of 20 mg/ kg/day was significantly increased above baseline " o 40- I 30" x X T UJ day 8 day 24 day 52 day 65 day 00 day 3J 30 i (24-29) 20" a (2-5) X w c (8-20) a. (day 6) (day 37) FIG. 5. Percentage PSP excretion in male rhess monkeys (A) and beagle dogs (B). Monkeys were gavaged with triclopyr at a dose of 5 mg/ kg/day for 28 days followed by an additional /day for 02 days (30 daily doses). PSP analysis was condcted on Days 8, 24, 52, 65, 00, and 3 of dosing. Dogs were fed triclopyr in their diet at a dose of 5 mg/ kg/day for 47 days and PSP was determined on dose Days 6 and 37. For monkeys, the vales represent means SD for for animals. Vales identified as statistically different are identified with an asterisk (*) (a = 0.05). For dogs, the vales represent mean for two animals and individal animal data are presented in parentheses. day (Day 60) was not significantly different from baseline clearance. para-aminohipprate clearance demonstrated a considerable degree of variability when measred on Day 26 following the /day dose, bt was comparable to Several stdies have sggested that, relative to other species, inclding hmans, the dog has a redced capacity to effectively eliminate organic acids via the kidneys (Timchalk et al., 996; Cherkofsky, 995; Gehring and Betso, 978; Hook et al., 974; Piper et al., 973). This stdy was condcted to evalate the effects of triclopyr administration on kidney fnction in the monkey and to compare their response to that observed in the dog. Blood rea nitrogen and serm creatinine are rotinely tilized to evalate renal fnction, althogh BUN and creatinine have limited sensitivity since renal fnction mst be decreased to 25% of normal or less to be detected by these measrements (Finco, 989; Schster and Seldin, 992). Nonetheless, the lack of an effect on BUN and creatinine levels in monkeys and dogs following repeated triclopyr administration sggests that triclopyr had no effect on normal kidney fnction in both species. Phenolslfonphthalein is a weak organic acid that is excreted by the kidneys primarily by an active secretory process in the proximal tbles (Finco, 980). In monkeys there was no evidence for a decrease in PSP excretion following repeated triclopyr exposre at doses of 5 or /day. In contrast, PSP excretion appeared to increase following repeated triclopyr doses of /day in the monkey. Since both triclopyr and PSP are reported to extensively bind to plasma proteins (Timchalk et al., 996; Ochwadt and Pitt, 962), a possible explanation for increased renal excretion of PSP may be the reslt of competition between triclopyr and PSP for the same plasma protein-binding sites. A shift to greater amonts of non-plasma-bond PSP wold enhance its glomerlar filtration increasing the percentage PSP excreted in the rine. Phenolslfonphthalein excretion in dogs was inversely related to plasma triclopyr concentration. At high plasma triclopyr concentrations (3-5 ^g triclopyr/ml plasma) PSP excretion was clearly depressed bt retrned to baseline as triclopyr plasma concentration decreased (~ ^g/ml). This effect of triclopyr on PSP excretion is consistent with a physiological response de to competition of triclopyr and PSP for the same active secretory system. These findings are consistent with those of Timchalk et al. (996), who sggested that, in the dog, the renal clearance of triclopyr involves both a high-affinity low-capacity active secretory site and glomerlar filtration of non-protein-bond triclopyr. In addition, nmeros stdies have demonstrated decreased renal clearance of organic acids, inclding PSP, when coadministered with other organic acids (Rssel et al., 989, 20- DISCUSSION
6 52 TMCHALK, FINCO, AND QUAST I s I 0 c (day 26) (day 60) 70" I 30 U (day 26) (day 60) FIG. 6. Inlin (A) and PAH (B) clearance in male rhess monkeys repeatedly administered triclopyr at a dose of /day for 28 days followed by an additional 02 days at /day (30 daily doses). Analysis was condcted on dose Days 26 and 60. The vales represent means SD for for animals. Vales identified as statistically different are identified with an asterisk ( ) (a = 0.05). 987; Mann et at., 99; Foreman, 984; Weiner, 973). Overall these data clearly indicate that triclopyr effectively competes with PSP for the active secretory site within the dog kidney proximal tbles. In contrast, the monkey appears to be insensitive to the effects of triclopyr on the active secretory process even at doses forfold higher (/ day) than the effective dose in the dog (/day). Inlin and PAH stdies were initiated as a means of fr- ACKNOWLEDGMENTS The athors thank T. Cooper (University of Georgia), S. C. Hansen, L. G. McFadden (The Dow Chemical Co.), and Dr. T. Griffin (International 0 ther evalating renal fnction in the monkey. The glomerlar filtration rate (GFR) as determined by inlin clearance represents a very sensitive test for renal fnction and has been reported to detect abnormalities with decrements as small as 20% (Schster and Seldin, 992). The reslts indicate that GFR as measred by inlin clearance was not affected by triclopyr administration and was well within the reported normal range of ml/min/kg for adlt male monkeys (Altman and Dittman, 974). These data spport the conclsion that triclopyr administration at doses as high as 20 mg/ kg/day did not adversely impact renal fnction or prodce associated renal toxicity in the monkey. para-aminohipprate is a weak organic acid that is extensively plasma protein-bond and is handled by the kidneys in a similar fashion as PSP (Finco, 989). The slightly elevated PAH clearance following the /day dose of triclopyr was consistent with PSP excretion data at this higher dose level. As noted for the effects seen with PSP, competition for plasma protein-binding between triclopyr and PAH is also a reasonable explanation for this slight increase in PAH clearance. The failre of triclopyr to decrease PAH clearance in the monkey provides additional spport for the conclsion that triclopyr does not significantly impact the active secretory process in monkeys. The findings in this stdy indicate that the monkey was insensitive to the effects of triclopyr and spport previos data which indicated that monkeys administered doses of triclopyr as high as 30 mg/kg/day for 28 days exhibited no treatment-related effects (976, npblished report of the Dow Chemical Co.). In contrast, dog renal physiology appears to be more sensitive to the effects of triclopyr administration. Perspective on the sensitivity of the dog to the renal effects of triclopyr and other organic acids sch as phenoxyacid herbicides (2,4-D, 2,4,5-T) and phenoxyalkanoic acids has been previosly reported (Timchalk et ai, 996; Gehring and Betso, 978). Allometric comparisons of triclopyr clearance and half-life between rat, dog, monkey, and hman clearly demonstrated that the dog has a decreased capacity to clear triclopyr relative to other species inclding hmans (Timchalk et ai, 996). Most recently, Cherkofsky (995) compared the pharmacokinetics of the organic acid -aminocyclopropanecarboxylic acid in the mose, rat, monkey, dog, and hman and likewise demonstrated that the dog has a significantly slower clearance and longer half-life for this organic acid. Collectively, these findings sggest that dogs have a redced capacity to clear organic acids, like triclopyr, and are consistent with the effects on renal fnction in dogs in this stdy. This niqe physiological response of the dog, relative to the monkey, raises into qestion the relevance of tilizing renal fnction changes in the dog as endpoints for hman risk extrapolation for organic acids sch as triclopyr.
7 TRICLOPYR EFFECTS ON RENAL FUNCTION 53 Center of Environmental Safety, Holloman AFB, NM) for their excellent technical assistance with this stdy. REFERENCES Altaian, P. L., and Dittmer, D. S. (974). Renal Fnction Test: Vertebrates. In Biology Data Book, 2nd ed., Vol. 3, pp Federation of Amer. Society for Exp. Biol., Bethesda, MD. Bratton, A. C, and Marshall, E. K., Jr. (939). A new copling component for slfanilamide determination. J. Biol. Chen 28, Carmichael, N. G., Nolan, R. J., Perkins, J. M., Davies, R., and Warrington, S. J. (989). Oral and dermal pharmacokinetics of triclopyr in hman volnteers. Hm. Toxicol. 8, Cherkofsky, S. C. (995). -Aminocyclopropanecarboxylic acid: Mose to man interspecies pharmacokinetic comparisons and allometric relationships. J. Pharmacol. Sci. 84(0), Cole, R., Giangiacomo, J., Inglefinger, J. R., and Robson, A. M. (972). Measrement of renal fnction withot rine collection. N. Engl. J. Med, 287, Dncan, J. R., and Prasse, K. W. (986). Veterinary Laboratory Medicine Clinical Pathology, 2nd ed. Iowa State Univ. Press, Ames, LA. Eisenbrandt, D. L., Landry, T. D., Fircha, H. M., Tsda, S., and Qast, J. F. (988). Dietary chronic toxicity and oncogenicity stdies of triclopyr in rats and mice. Toxicologist 8, 704. Rnco, D. R. (97). Simltaneos determination of phenolslfonphthalein excretion and endogenos creatinine clearance in the normal dog. J. Am. Vet. Med. Assoc. 59, Rnco, D. R. (980). Kidney fnction. In Clinical Biochemistry of Domestic Animals (J. J. Kaneko, Ed.), pp Academic Press, New York. Finco, D. R. (989). Kidney fnction. In Clinical Biochemistry of Domestic Animals (J. J. Kaneko, Ed.), pp Academic Press, New York. Finco, D. R. (993). Endogenos creatinine clearance measrement of glomerlar filtration rate in dogs, enzymatic method of creatinine assay. Am. J. Vet. Res. 54, Foreman, J. W. (984). Renal handling of rate and other organic acids. In Canine Nephrology (K. C. Bovee, Ed.), Chap. 7, pp Harwal. Gehring, P. J., and Betso, J. E. (978). Phenoxy acids: Effects and fate in mammals. In Chlorinated Phenoxy Acids and Their Dioxins (C. Ramel, Ed.), Vol. 27, pp Ecol. Bll., Stockholm. Heyrovsky, A. (956). A new method for the determination of inlin in plasma and rine. Clin. Chim. Ada, Hook, J., Bailie, M. D., Johnson, J. T., and Gehring, P. J. (974). In vitro analysis of transport of 2,4,5-trichlorophenoxyacetic acid by rat and dog kidney. Food Cosmet. Toxicol. 2, Hook, J., Cardona, R., Osborn, J. L., and Bailie, M. D. (975). The renal handling of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) in the dog. Food Cosmet. Toxicol. 4, Landry, T. D., Eisenbrandt, D. L., Gshow, T. S., Phillips, J. E., and Wackerly, D. L. (985). Triclopyr: 3-week dietary toxicity stdy and 4-week pharmacokinetic stdy in Fischer 344 rats. Toxicologist 5,. Mann, W. A., Welzel, G. E., Goldstein, R. S., Sozio, R. S., Cyronak, M. J., Kao, J., and Kinter, L. (99). Characterization of the renal effects and renal elimination of slotroban in the dog. J. Pharmacol. Exp. Ther. 259(3), Ochwadt, IC, and Pitts, R. F. (962). Disparity between phenol red and diodrast clearances in the dog. Am. J. Physiol. 87, Osborne, C. A., Low, D. G., and Finco, D. R. (972). Canine and Feline Urology, pp Sanders, Philadelphia, PA. Piper, W. N., Rose, J. Q., Leng, M. L., and Gehring, P. J. (973). The fate of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) following oral administration to rats and dogs. Toxicol. Appl. Pharmacol. 26, Rssel, F. G. M., Woterse, A. C, and Van Ginneken, C. A. M. (987). Physiological based pharmacokinetic model for the renal clearance of salicylric acid and the interaction with phenolslfonphthalein in the dog. Drg Metab. Dispos. 5, Rssel, F. G. M., Woterse, A. C, and Van Ginneken, C. A. M. (989). Physiological based pharmacokinetic model for the renal clearance of iodopyracet and the interaction with probenecid in the dog. Biopharm. Drg Dispos. 0, Schster, V. L., and Seldin, D. W. (992). Renal clearance. In The Kidney: Physiology and Pathophysiology (D. W. Seldin and G. Giebisch, Eds.), pp Raven Press, New York. Smith, H. W., Finkelstein, N., Aliminosa, L., Crawford,, and Graber, M. (945). The renal clearance of sbstitted hippric acid derivatives and other aromatic acids in dog and man. J. Clin. Invest. 24, Steel, R. G. D., and Tome, J. H. (980). Principles and Procedres of Statistics, 2nd ed., McGraw-Hill, New York. Timchalk, C, Dryzga, M. D., and Kastl, P. E. (990). Pharmacokinetics and metabolism of triclopyr (3^,6-trichloro-2-pyridinyloxyacetic acid) in Fischer 344 rats. Toxicology 62, Timchalk, C, Lacher, J. W., Dryzga, M. D., Pottenger, L. H., and Hansen, S. C. (996). Pharmacokinetics and renal clearance of triclopyr in the male beagle dog. Toxicologist 30(2), 265. Weiner, I. M. (973). Transport of weak acids and bases. In Handbook of Physiology, Section 8: Renal Physiology, Chap. 7, pp American Physiol. Soc. Williams & Wilkins, Baltimore, MD. Worthing, C. R. (987). The Pesticide Manal, 8th ed., p British Crop Protection Concil.
JEJUNAL AND ILEAL ABSORPTION OF DIBASIC AMINO ACIDS AND AN ARGININE-CONTAINING DIPEPTIDE IN CYSTINURIA
GASTROENTEROLOGY 68:1426-1432, 1975 Copyright 1975 by The Williams & Wilkins Co. Vol. 68, No.6 Printed in U.S.A JEJUNAL AND ILEAL ABSORPTION OF DIBASIC AMINO ACIDS AND AN ARGININE-CONTAINING DIPEPTIDE
More informationRole of the Sympathetic Nervous System
Role of the Sympathetic Nervos System in the Renal Response to Hemorrhage JOHN R. GCL, JR., and AimED G. T. CASPER From the Endocrinology Branch, National Heart Institte, National Instittes of Health,
More informationStatistical Analysis of Method Comparison Data
Statistical Analysis of Method Comparison Data Testing rmality GEORGE S. CEMBROWSKI, PH.D., JAMES O. WESTGARD, PH.D., WILLIAM J. CONOVER, PH.D., AND ERIC C. TOREN, JR., PH.D. Cembrowski, George S., Westgard,
More informationTREATMENT of hypogonadotropic hypogonadism
0021-72X/5/4-074$00/0 Jornal of Clinical Endocrinology and Metabolism Copyright 15 by The Endocrine Society Vol. 1, No. 4 Printed in U.S.A. Male Hypogonadotropic Hypogonadism: Factors Inflencing Response
More informationSample Size and Screening Size Trade Off in the Presence of Subgroups with Different Expected Treatment Effects
Sample Size and Screening Size Trade Off in the Presence of Sbgrops with Different Expected Treatment Effects Kyle D. Rdser, Edward Bendert, Joseph S. Koopmeiners Division of Biostatistics, School of Pblic
More informationEffects of alpha-1 adrenergic receptor antagonist, terazosin, on cardiovascular functions in anaesthetised dogs
Indian Jornal of xperimental Biology Vol. 42, December 24, pp. 1195-1199 ffects of alpha-1 adrenergic receptor antagonist, terazosin, on cardiovasclar fnctions in anaesthetised dogs R Sharma & V M Ahja
More informationPharmacokinetics of phenylpropanolamine in humans after a single-dose study
International Jornal of Pharmacetics, 39 (1987) 141-148 Elsevier 141 I1P 01319 Pharmacokinetics of phenylpropanolamine in hmans after a single-dose stdy R. Dose, J.M. Haigh and I. Kanfer School of Pharmacetical
More informationPULSATILE UREA EXCRETION IN GULF TOADFISH (OPSANUS BETA): EVIDENCE FOR ACTIVATION OF A SPECIFIC FACILITATED DIFFUSION TRANSPORT SYSTEM
The Jornal of Experimental Biology 21, 85 817 (1998) Printed in Great Britain The Company of Biologists Limited 1998 JEB1158 85 PULSATILE UREA EXCRETION IN GULF TOADFISH (OPSANUS BETA): EVIDENCE FOR ACTIVATION
More informationRegister studies from the perspective of a clinical scientist
Register stdies from the perspective of a clinical scientist Sofia Sederholm Lawesson, MD, PhD Department of Cardiology, Linköping University Hospital and Department of Medical and Health Sciences, Linköping
More informationExercise testing in pulmonary arterial hypertension and in chronic heart failure
Er Respir J 2004; 23: 747 751 DOI: 10.1183/09031936.04.00111904 Printed in UK all rights reserved Copyright #ERS Jornals Ltd 2004 Eropean Respiratory Jornal ISSN 0903-1936 Exercise testing in plmonary
More informationLeft Ventricular Mass and Volume: Fast Calculation with Guide-Point Modeling on MR Images 1
Alistair A. Yong, PhD Brett R. Cowan, BE, MBChB Steven F. Thrpp, MA Warren J. Hedley, ME Lois J. Dell Italia, MD Index terms: Heart, volme, 51.92 Magnetic resonance (MR), phase imaging, 51.12144 Magnetic
More informationAn investigation of ambiguous-cue learning in pigeons
Animal Learning & Behavior 19808(2)282-286 An investigation of ambigos-ce learning in pigeons GEOFFREY HALL University ofyork York YOJ 5DD England Two experiments demonstrated that pigeons can solve a
More informationIn Vivo Inactivation of Lysozyme by Ozone
JOURNAL of BACTERIOLOGY, Nov. 1968, p. 1562-1566 Copyright 1968 American Society for Microbiology Vol. 96, No. 5 Printed in U.S.A. In Vivo Inactivation of Lysozyme by Ozone R. S. HOLZMAN, D. E. GARDNER,
More informationAllergic asthma is characterised by bronchial. Montelukast as add-on therapy to b-agonists and late airway response
Er Respir J 2007; 30: 56 61 DOI: 10.1183/09031936.00063106 CopyrightßERS Jornals Ltd 2007 Montelkast as add-on therapy to b-agonists and late airway response M. Rosewich, M.A. Rose, O. Eickmeier, M. Travaci,
More informationWilson's disease (hepatolenticular degeneration)
RENAL FUNCTION IN WILSON'S DISEASEI By A. G. BEARN, T. F. YtU, AND A. B. GUTMAN (From the Rockefeller Institte for Medical Research, and the Departments of Medicine, The Mont Sinai Hospital, and Colmbia
More informationCulture Bias in Clinical Assessment: Using New Metrics to Address Thorny Problems in Practice and Research
Cltre Bias in Clinical Assessment: Using New Metrics to Address Thorny Problems in Practice and Research MICHAEL CANUTE LAMBERT 1 GEORGE T. ROWAN 2 FREDRICK HICKLING 3 MAUREEN SAMMS VAUGHAN 3 1 The niversity
More informationCC (in oitro)=computation constant for in oitro 8uid Row;
Detection of Renal Blood Flo Abnormalities in Septic and Critically Ill Patients Using a Nely Designed Indelling Thermodiltion Renal Vein Catheter* Matthe Brenner; M.D.; Gary L. Schaer; M.D.; Doglas L.
More informationThe Leicester Cough Monitor: preliminary validation of an automated cough detection system in chronic cough
Er Respir J 2008; 31: 1013 1018 DOI: 10.1183/09031936.00057407 CopyrightßERS Jornals Ltd 2008 The Leicester Cogh Monitor: preliminary validation of an atomated cogh detection system in chronic cogh S.S.
More informationOutcomes for COPD pharmacological trials: from lung function to biomarkers
Er Respir J 2008; 31: 416 468 DOI: 10.1183/09031936.00099306 CopyrightßERS Jornals Ltd 2008 ATS/ERS TASK FORCE Otcomes for COPD pharmacological trials: from lng fnction to biomarkers M. Cazzola, W. MacNee,
More informationTRICHOMES AND CANNABINOID CONTENT OF DEVELOPING LEAVES AND BRACTS OF CANNABIS SATIVA L. (CANNABACEAE) 1
Arner. J. Bot. 67(1): 1397-146. 198. TRCHOMS AND CANNABNOD CONTNT OF DVLOPNG LAVS AND BRACTS OF CANNABS SATVA L. (CANNABACA) 1 JOCLYN C. TURNR, JOHN K. HMPHLL, AND PAUL G. MAHLBRG Department of Biology,
More informationInvacare Matrx Libra
Invacare Matrx Libra Clinical Evidence Introdction The Matrx Libra cshion is designed to optimise each of the following three featres, offering the highest level of skin protection and positioning, even
More informationLEUKOCYTE AND LYMPHOCYTE CYCLIC AMP RESPONSES IN ATOPIC ECZEMA
THE JOtJllNAL OP INvESTJGATIV1! DE.IlMATOLOGY. 68:302-306, 1977 Copyright 0 1977 by The Williams & Wilkins Co. VoL 68, No. 5 Printed in U.SA. LEUKOCYTE AND LYMPHOCYTE CYCLIC AMP RESPONSES IN ATOPIC ECZEMA
More informationTHE EFFECT OF INTRAUTERINE PROGESTERONE TREATMENT ON THE ENDOMETRIAL PROSTAGLANDIN F CONTENT IN THE RABBIT*
FERTILITY AND STERILITY Copyright 1977 The American Fertility Society Vol. 2, No.5, May 1977 Printed in U.s.A. THE EFFECT OF INTRAUTERINE PROGESTERONE TREATMENT ON THE ENDOMETRIAL PROSTAGLANDIN F CONTENT
More informationHEPTADECAPEPTIDE GASTRIN: MEASUREMENT IN BLOOD BY SPECIFIC RADIOIMMUNOASSAY
GASTROENTEROLOGY 71:971-977. 1976 Copyright @ 1976 by The Williams & Wilkins Co. Vol. 71.!IIo. 6 Printed In U.S.A. HEPTADECAPEPTIDE GASTRIN: MEASUREMENT IN BLOOD BY SPECIFIC RADIOIMMUNOASSAY GRAHAM J.
More informationPolysaccharide Hydrolysis and Metallic Impurities Removal Behavior of Rice Husks in Citric Acid Leaching Treatment
Transactions of JWRI, Vol.3 (9), No. Polysaccharide Hydrolysis and Metallic Imprities Removal Behavior of Rice Hsks in Citric Acid Leaching Treatment UMEDA Jnko*, IMAI Hisashi * and KONDOH Katsyoshi **
More informationIncentives, information, rehearsal, and the negative recency effect*
Memory & Cognition 1974, Vol. 2, No. 2, 295-300 Incentives, information, rehearsal, and the negative recency effect* LEAH L. LIGHTt Pitzer College, Claremont, California 91711 The negative recency effect
More informationDeterminants of Cancer Screening Frequency: The Example of Screening for Cervical Cancer
ORIGINAL ARTICLES Determinants of Cancer Screening Freqency: The Example of Screening for Cervical Cancer Pal S. Frame, MD, and J Stherland Frame, PhDt Backgrond: Cancer screening freqency shold be based
More informationSexual Behavior, HIV, and Fertility Trends: A Comparative Analysis of Six Countries
Sexal Behavior, HIV, and Fertility Trends: A Comparative Analysis of Six Contries Phase I of the ABC Stdy Prepared by: Rth Bessinger Priscilla Akwara Daniel Halperin This report was prepared by USAID and
More informationWATSON CLINIC CANCER & RESEARCH CENTER WATSON CLINIC CANCER & RESEARCH CENTER
Colon cancer is the only PREVENTABLE cancer, which can be achieved throgh screening colonoscopy beginning at age 50, or sooner if there is a family history. Or objective is to bring awareness to the pblic
More informationMould exposure at home relates to inflammatory markers in blood
Er Respir J 2003; 21: 317 322 DOI: 10.1183/09031936.03.00283603 Printed in UK all rights reserved Copyright #ERS Jornals Ltd 2003 Eropean Respiratory Jornal ISSN 0903-1936 Mold exposre at home relates
More informationu Among postmenopausal women, hormone therapy with u CEE plus MPA for a median of 5.6 years or u CEE alone for a median of 7.
Menopase Update SHELAGH LARSON, MS, RNC WHNP, NCMP ACCLAIM, JPS HEALTH NETWORK the only large, long-term RCT of HT in women aged 50 to 79 years, Drg trail for HT on chronic diseases WHI (HT oral, only)
More informationRELATIONSHIPS OF MECHANICAL POWER TO PERCEIVED EXERTION AND VARIOUS PHYSIOLOGICAL PARAMETERS MEASURED IN ELITE YOUTH DISTANCE RUNNERS AND CONTROLS
RELATIONSHIPS OF MECHANICAL POWER TO PERCEIVED EXERTION AND VARIOUS PHYSIOLOGICAL PARAMETERS MEASURED IN ELITE YOUTH DISTANCE RUNNERS AND CONTROLS Egene W. Brown, Pal Vogel, Byeong Hwa Ahn and Sharon Evans
More informationPulmonary Hypertension In Pediatrics
Plmonary Hypertension In Pediatrics This talk will focs on the cases and treatment of the more common things we see in pediatrics. This incldes: Persistent Plmonary Hypertension of the Newborn. Plmonary
More informationTricarboxylic Acid Metabolism Studies in the Ovary Throughout the Menstrual Cycle. S. J. Behrman, M.D., M.R.C.O.G., and Gregory S. Duboff, M.S., D.Sc.
Tricarboxylic Acid Metabolism Stdies in the Ovary Throghot the Menstral Cycle S. J. Behrman, M.D., M.R.C.O.G., and Gregory S. Dboff, M.S., D.Sc. THE VARIOUS ENDOCRINE CHANGEs dring the hman menstral cycle
More informationHepatitis C & B Co-infection PROJECT ECHO HEPC FEBRUARY 9, 2017 PRESENTED BY: DR. JOHN GUILFOOSE
Hepatitis C & B Co-infection PROJECT ECHO HEPC FEBRUARY 9, 2017 PRESENTED BY: DR. JOHN GUILFOOSE Intro Shared modes of transmission Viral interactions / concept of a Dominant virs Not ncommon in highly
More informationEFFECT OF CHLORPROMAZINE, RESERPINE, BENACTYZINE AND PHENOBARBITONE ON THE RELEASE OF CORTICOTROPHIN IN THE RAT
Brit. J. Pharmacol. (1962), 19, 458-463. EFFECT OF CHLORPROMAZNE, RESERPNE, BENACTYZNE AND PHENOBARBTONE ON THE RELEASE OF CORTCOTROPHN N THE RAT BY A. ASHFORD AND M. SHAPERO* From the Pharmacology Department,
More informationSTUDIES ON ALCOHOL DIURESIS. II. THE EVALUATION OF ETHYL ALCOHOL AS AN INHIBITOR OF THE NEUROHYPOPHYSIS
STUDES ON ALCOHOL DURESS.. THE EVALUATON OF ETHYL ALCOHOL AS AN NHBTOR OF THE NEUROHYPOPHYSS Charles R. Kleeman,, Ezra Lamdin, Franklin H. Epstein J Clin nvest. 1955;3(3):855. https://doi.org/1.1172/jc1393.
More informationRight Ventricular Impella Order Set Page 1 of 4
Right Ventriclar Impella Order Set Page 1 of 4 Pt. Identifier See Cardiovasclar Post-Operative IC Order Set See Cardiology Interventional POST Orders O aily 0. PATIENT WEIGHT: kg (reqired) PATIENT HEIGHT:
More informationThe timed walk test as a measure of severity and survival in idiopathic pulmonary fibrosis
Er Respir J 2005; 25: 96 103 DOI: 10.1183/09031936.04.00137203 CopyrightßERS Jornals Ltd 2005 The timed walk test as a measre of severity and srvival in idiopathic plmonary fibrosis T.S. Hallstrand*, L.J.
More informationEFFECTS OF PROBENECID, SODIUM SALICYLATE, 2,4-DINITROPHENOL AND PYRAZINAMIDE ON RENAL SECRETION OF URIC ACID IN CHICKENS
8189 EFFECTS OF PROBENECID, SODIUM SALICYLATE, 2,4-DINITROPHENOL AND PYRAZINAMIDE ON RENAL SECRETION OF URIC ACID IN CHICKENS BOHDAN R. NECHAY AND LARYSSA NECHAY Department of Pharmacology and Therapeutics,
More informationAn Update on DOACs and HAYLEY BLACKBURN, PHARM.D., BCACP
An Update on DOACs and Treatment of VTE HAYLEY BLACKBURN, PHARM.D., BCACP Learning Objectives Explain the crrent role of DOACs in the treatment and prevention of VTE Describe crrent evidence for giding
More informationQuantitative Fecal Indium Ill-Labeled Leukocyte Excretion in the Assessment of Disease in Crohn's Disease
GASTROENTEROLOGY 1983;85:1333-9 Qantitative Fecal Indim Ill-Labeled Lekocyte Excretion in the Assessment of Disease in Crohn's Disease S. H. SAVERYMUTTU, A. M. PETERS, J. P. LAVENDER, M. B. PEPYS, H. J.
More informationNORLAND AVENUE PHARMACY PRESCRIPTION COMPOUNDING FOR VETERINARY MEDICINE
OCTOBER 2011 PRESCRIPTION COMPOUNDING N ORLANDA VENUEP HARMACY. COM We customize individual prescriptions for the specific needs of our patients. INSIDE THIS ISSUE: Feline Analgesic Agent Feline Hypertension
More information1 Thinking Critically With Psychological Science
CHAPTER 1 Thinking Critically With Psychological Thinking Critically Science With Psychological Science Preview The scientific attitde reflects an eagerness to skeptically scrtinize competing ideas with
More informationPreview and Preparation Pack. AS & A2 Resources for the new specification
Preview and Preparation Pack AS & A2 Resorces for the new specification For first teaching in September 2008 ...working together to provide better spport for yo. As part of 14-19 crriclm change, OCR is
More informationThe Future of HIV Care in Nevada TRUDY LARSON, MD PROFESSOR AND DEAN, SCHOOL OF COMMUNITY HEALTH SCIENCES UNIVERSITY OF NEVADA, RENO
The Ftre of HIV Care in Nevada TRUDY LARSON, MD PROFESSOR AND DEAN, SCHOOL OF COMMUNITY HEALTH SCIENCES UNIVERSITY OF NEVADA, RENO Learning Objectives Identify the similarities and differences between
More informationNorth Wales Area Planning Board for Substance Misuse
North Wales Area Planning Board for Sbstance Misse Annal Report 2014-15 Index NW APB Sbstance Misse Annal Report 2014-15 Foreword - Chair of the Area Planning Board... 1 Introdction - NW APB Regional Commissioning
More informationContrast Affects Flicker and Speed Perception Differently
Pergamon PH: S42-6989(96)32.1 Vision Res., VoL 37, No. 1, pp. 1255-126, 1997 1997 Elsevier Science Ltd. All rights reserved Printed in Great Britain 42-6989197 $17. + : Contrast Affects Flicker and Speed
More informationHow can skin conductance responses increase over trials while skin resistance responses decrease?
Physiological Psychology 1985. Vol. 13 (4). 291-295 How can skin condctance responses increase over trials while skin resistance responses decrease? MANFRED VELDEN University of Osnabrock. Osnabrock. West
More informationClassification of ADHD and Non-ADHD Using AR Models and Machine Learning Algorithms
Classification of ADHD and Non-ADHD Using AR Models and Machine Learning Algorithms Jan Lopez Marcano Thesis sbmitted to the Faclty of the Virginia Polytechnic Institte and State University in partial
More informationMR Detection of Brain Iron
MR Detection of Brain Iron Lara. Thomas, 1 Orest B. Boyko, 1 ' 2 Doglas C. Anthony, 2 and Peter C. Brger 2 PURPOSE: To provide frther qantitative stdies concerning the relationship with age between regional
More informationQUANTITATIVE HISTOCHEMISTRY OF NICOTINAMIDE ADENINE NUCLEOTIDES IN HUMAN SKIN*
THE JOURNAL OF INVESTIGATIVE DERMATOLOGY Copyright 1970 by The Williams & Wilkins Co. Vol. 55 No. 4 Printed in U.S.A. QUANTITATIVE HISTOCHEMISTRY OF NICOTINAMIDE ADENINE NUCLEOTIDES IN HUMAN SKIN* MICHAEL
More informationRecommendations. for the Governance & Administration of Destination Marketing Fees
Recommendations for the Governance & Administration of Destination Marketing Fees Febrary 2011 Alberta Hotel & Lodging Association Destination Marketing Fee Recommendations Introdction & Backgrond Since
More informationcystic fibrosis today
Key points Median srvival in CF is crrently 36 years and contines to improve. A child born today with CF may expect to live into their 6th decade. CF is a spectrm of disease, ranging from severe to mild
More informationCumulative pregnancy rates for in vitro fertilization
FERTLTY AND STERLTY Copyright 1986 The American Fertility Society Printed in U.8A. Cmlative pregnancy rates for in vitro fertilization David S. Gzick, M.D., Ph.D.* Charles ilkes, M.D.t Hoard. Jones, Jr.,
More informationCENTER FOR VIOLENCE PREVENTION
CENTER FOR VIOLENCE PREVENTION ANNUAL REPORT 2017 CONTENTS Mission of the Center for Violence Prevention 3 Spporting UNI Vision, Mission and Strategic Plan: 2017-2022 4 History 5 Commnity Engagement: Professional
More information(Received 23 January 1961) Crawford & Kennedy (1959) found the prolonged saluretic and diuretic
454 J. Phyeiol. (1961), 157, pp. 454-461 With 3 text-figure Printed in Great Britain THE ACTION OF CHLOROTHIAZIDE IN THE PERFUSED CAT KIDNEY BY T. DE LIMA AND MARY F. LOCKETT From the Department of Physiology
More informationEnzyme-linked Immunoassay Index for Anti-NC16a IgG and IgE Autoantibodies Correlates with Severity and Activity of Bullous Pemphigoid
Acta Derm Venereol 2016; 96: 191 196 INVESTIGATIVE REPORT Enzyme-linked Immnoassay Index for Anti-NC16a IgG and IgE Atoantibodies Correlates with Severity and Activity of Bllos Pemphigoid Monika KALOWSKA
More informationSelf-control trainings: What we (do not) know so far
Backgrond Stdy 1 Discssion Self-control trainings: What we (do not) know so far Malte Friese Saarland University With Jlis Frankenbach, Veronika Job, David Loschelder, Katharina Bernecker Self-Control
More informationMedicine, Cambridge, England, and Wuppertal, B.A.O.R.
182 J. Physiol. (I948) I07, i82-i86 6I2.46I.62 PHOSPHATE CLEARANCES IN INFANTS AND ADULTS BY R. F. A. DEAN AND R. A. McCANCE From the Medical Research Council, Department. of Experimental Medicine, Cambridge,
More informationIncreased follicular fluid total and free cortisol levels during the luteinizing hormone surge
FRTILITY AND STRILITY Copyright" 1997 American Society for Reprodctive Medicine Pblished by lsevier Science Inc. Vol. 68, No.1, Jly 1997 Printed on acid-free paper in U S. A. Increased folliclar flid total
More informationLeft Ventricular Impella 5.0/CP/2.5 Order Set Page 1 of 4
Left Ventriclar Impella 5.0/CP/2.5 Order Set Page 1 of 4 See Cardiovasclar Post-Operative IC Order Set See Cardiology Interventional POST Orders 04 PATIENT WEIGHT: kg (reqired) PATIENT HEIGHT: cm (reqired)
More informationHistory of Prostate Cancer Screening and Current CUA Guidelines
History of Prostate Cancer Screening and Crrent CUA Gidelines COLIN LUNDEEN FEBRUARY 7, 2018 Objectives Review the history of prostate cancer (PCa) screening History of Prostate Specific Antigen (PSA)
More informationThe Biology of Mind. Preview
CHAPTER 2 The Biology of Mind Preview Or nervos system plays a vital role in how we think, feel, and act. Nerons, the basic bilding blocks of the body s circitry, receive signals throgh their branching
More informationBlood urea nitrogen (BUN) and serum creatinine concentrations
J Vet Intern Med 2001;15:368 373 Relationship between Plasma Iohexol Clearance and Urinary Exogenous Creatinine Clearance in Dogs Delmar R. Finco, W. Emmett Braselton, and Tanya A. Cooper The objective
More informationStarch Digestion in Normal Subjects and Patients With Pancreatic Disease, Using a
GASTROENTEROLOGY 1989;96:53-9 Starch Digestion in Normal Sbjects and Patients With Pancreatic Disease, Using a 13C2 Breath Test M. HIELE, Y. GHOOS, P. RUTGEERTS, and G. VANTRAPPEN Department of Internal
More informationSynchronous Oscillations in the Basal Secretion of Pancreatic-Polypeptide and Gastric Acid
Synchronos Oscillations in the Basal Secretion of Pancreatic-Polypeptide and Gastric Acid Depression by Cholinergic Blockade of Pancreatic-Polypeptide Concentrations in Plasma TH. SCHART, BO STNST, LARS
More informationAutoencoder networks for HIV classification
Atoencoder networks for HIV classification Brain Leke Betechoh*, Tshilidzi Marwala and Thando Tettey In this paper, we introdce a new method to analyse HIV sing a combination of atoencoder networks and
More informationMe? Debunk a Vancomycin myth?... Take my life in my hands?
Me? Debnk a Vancomycin myth?... Take my life in my hands? BRUCE DALTON PHARM.D. ALBERTA HEALTH SERVICES CALGARY BRUCE.DALTON@ALBERTAHEALTHSERVICES.CA Disclosres No financial or other conflicts of interest
More informationAACE/ACE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM. Sherwin D Souza, MD, FACE
AACE/ACE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM Sherwin D Soza, MD, FACE Prediabetes Treatment Algorithm T2DM = type 2 diabetes mellits BP = blood pressre CVD = cardiovasclar disease
More informationQuinpirole and d-amphetamine administration posttraining enhances memory on spatial
Psychobiology 1994. 22 (1). 54-6 Qinpirole and d-amphetamine administration posttraining enhances memory on spatial and ced discriminations in a water maze MARK G. PACKARD and JAMES L. McGAGH niversity
More informationA simple spectrophotometric assay for long-chain acyl-coa dehydrogenase activity measurements in human skin fibroblasts
Original Article Ann Clin Biochem 1993; 30: 293-297 A simple spectrophotometric assay for long-chain acyl-coa dehydrogenase activity measrements in hman skin fibroblasts Lodewijk Ijlst and Ronald J A Wanders!
More informationLong-term effects of food deprivation: II. Impact on morphine reactivity
Psychobiology 1992, 20 (1), 85-91 Long-term effects of food deprivation: II. Impact on morphine reactivity MANDY K. Bll..ES, PAUL A. ll..lich, and JAMES W. GRAU Texas A& M University, College Station,
More informationwater, sodium and potassium homeostasis
Lectre-3 water, sodim and potassim homeostasis Dr. Khalid Al-Ani Department of Clinical Pharmacy Faclty of Pharmacy Water & sodim balance Internal and external balance Internal balance is the distribtion
More informationTHE ACTION OF ANTISYMPATHOMIMETIC DRUGS ON THE URINARY EXCRETION OF ADRENALINE AND NORADRENALINE
Brit. J. Pharmacol. (1959), 14, 380. THE ACTION OF ANTISYMPATHOMIMETIC DRUGS ON THE URINARY EXCRETION OF ADRENALINE AND NORADRENALINE BY B. G. BENFEY, G. LEDOUX, AND M. SEGAL From the Department ofpharmacology,
More informationScratch and Match: Pigeons Learn Matching and Oddity With Gravel Stimuli
Scratch and Match: Pigeons Learn Matching and Oddity With Gravel Stimli Anthony A. Wright and Jan D. Delis Two grops of 4 pigeons learned either matching-to-sample or oddity-from-sample by digging in white
More informationRadio Frequency Exposure Risk Assessment and Communication Critique of ARPANSA TRS-164 Report: Do we have a problem? Victor Leach and Steven Weller
Radio Freqency Exposre Risk Assessment and Commnication Critiqe of ARPANSA TRS-164 Report: Do we have a problem? Victor Leach and Steven Weller 1 ORSAA Database Oceania Radiofreqency Scientific Advisory
More informationControlled processing in pigeons
Animal Learning & Behavior /984, /2 (3), 285-29/ Controlled processing in pigeons RTH M. COLILL niversity of Cambridge, Cambridge. England This paper investigates hether rehearsal, or posttrial processing,
More information8/8/17. A Collaborative Concussion Culture Karen McAvoy, PsyD. Second Impact Syndrome (SIS) REAP The Benefits of Good Concussion Management
8/8/17 A Collaborative Concssion Cltre Karen McAvoy, PsyD Agst 10, 2017 Second Impact Syndrome (SIS) How every family, school and medical professional can create a Commnity-Based Concssion Management Program
More informationHelping Families Navigate Addiction. Presented by: Kristy Roll, LCSW, Director of Family Services, Cumberland Heights
Helping Families Navigate Addiction Presented by: Kristy Roll, LCSW, Director of Family Services, Cmberland Heights What does addiction look like? Denial Irritability/argmentativeness Broken promises to
More informationBIOL 2402 Renal Function
BIOL 2402 Renal Function Dr. Chris Doumen Collin County Community College 1 Renal Clearance and GFR Refers to the volume of blood plasma from which a component is completely removed in one minute by all
More informationRespiratory heat and moisture loss is associated with eosinophilic inflammation in asthma
Er Respir J 2007; 29: 676 681 DOI: 10.1183/09031936.00071106 CopyrightßERS Jornals Ltd 2007 Respiratory heat and moistre loss is associated with eosinophilic inflammation in asthma D.D. Noble, J.B. McCafferty,
More informationDistribution and concentration of cyclosporin in human blood
J Clin Pathol 1984;37:1167-1171 Distribtion and onentration of ylosporin in hman blood KERRY ATKINSON, KATHRYN BRITTON, JAMES BIGGS From the Department ofhaematology, St Vinent's Hospital, Sydney, New
More informationExperimental Methods 2/9/18. What is an Experimental Method?
Experimental Methods Joseph Alvarez, Vanesa Castro, Liliana Hernandez, Marissa Silva What is an Experimental Method? Maniplating one variable (IV)to see if the change in one variable cases the other variable
More informationInstantaneous Measurement and Diagnosis
Instantaneos Measrement and Diagnosis John M Linacre, PhD MESA Psychometric Laboratory University of Chicago The manfactre ofmeasring instrments is typically a large-scale, standards, based process Their
More informationTHE EFFECT OF ASCORBIC ACID ON RENAL FUNCTION IN DOGS WITH ISCHEMIA REPERFUSION INJURY
Nigerian Veterinary Journal 2010 Vol 31(1):66-70 THE EFFECT OF ASCORBIC ACID ON RENAL FUNCTION IN DOGS WITH ISCHEMIA REPERFUSION INJURY KISANI 1 A.I* and AKINRIMADE 2 J.F 1 Department of Veterinary Surgery
More informationThis series of articles will
1 Introdction This series of articles will address some of the practical isses of processing poltry and how to prevent carcass downgrading and problems. Chicken is a versatile and healthy meat and the
More informationPlasma exchange, which was first introduced over 10
Plasma Exchange and Low Density Lipoprotein Apheresis in Watanabe Heritable Hyperlipidemic Rabbits Masakats Kano, Jnji Koizmi, Arvind Jadhav, and Gilbert R. Thompson Comparison of the effects of plasma
More informationDosage and Important Administration Instructions. Shake vial for 5 to 8 seconds
STEP-BY-STEP GUIDE TIPRI (ciprofloxacin otic sspension) 6% Have all materials ready ne vial of TIPRI (enogh for doses) Two ml ler lock syringes wo 8-G T preparation needles wo 0-4G, T -3 inch blnt, flexible
More informationPreview. Guide. Introductory Exercise: Fact or Falsehood?
The Story The Story of Psychology of Psychology Preview Gide Psychology traces its roots back to Greek philosophers reflections on hman natre. Psychologists initial focs on mental life was replaced in
More informationThe Ins and Outs of Enteral Nutrition
1 The Ins and Ots of Enteral Ntrition KELLY GREEN CORKINS, MS, RD-AP, CSP, LDN, FAND CLINICAL DIETITIAN III, LE BONHEUR CHILDREN S HOSPITAL, MEMPHIS, TN Disclosres 2 Abbott Speakers Brea honoraria (Not
More information9/5/17. Words Make Worlds! Operationalising Well-Being and Decoding Distress. Framework for Restoring Well-Being. Caution. Personal Transformation
Dementia is a shift in the way a person experiences the world arond her/him. Operationalising Well-Being and Decoding Distress G. Allen Power, MD, FACP Folk med Demens Konference 21 September 2017 Framework
More informationSUPPORTING PREGNANT AND PARENTING WOMEN WHO USE SUBSTANCES What Communities are Doing to Help
SUPPORTING PREGNANT AND PARENTING WOMEN WHO USE SUBSTANCES What Commnities are Doing to Help Commnities across Canada are becoming increasingly aware of isses related to pregnancy, alcohol and sbstance
More informationClearance of Gut-Derived Endotoxins by the Liver
GASTROENTEROLOGY 1989;96:456-61 Clearance of Gt-Derived Endotoxins by the Liver Release and Modification of 3H, 14 C-Lipopolysaccharide by Isolated Rat Kpffer Cells EBEN S. FOX, PETER THOMAS, and SELWYN
More informationTRACE ELEMENTS IN THE HAIRS OF WINTERING MEMBERS OF THE 13TH JAPANESE ANT ARCTIC RESEARCH EXPEDITION. Hiroshi KozuKA * and Yukio KANDA *
64 TRACE ELEMENTS N THE HARS OF WNTERNG MEMBERS OF THE 13TH JAPANESE ANT ARCTC RESEARCH EXPEDTON Hiroshi KozKA * and Ykio KANDA * Abstract: The concentrations of six trace elements, Hg, A, C, Zn, Sb and
More informationNature, Nurture, and Human Diversity
CHAPTER 4 Preview Natre, Nrtre, and Hman Diversity Members of the hman family share common behavioral tendencies bt are also strikingly diverse. To what extent are we shaped by or heredity and to what
More informationAdvance Care Planning in the Chronic Kidney Disease Population A Quality Improvement Project
Advance Care Planning in the Chronic Kidney Disease Poplation A Qality Improvement Project BARBARA WEIS MALONE DNP, FNP-C, FNKF ASSOCIATE PROFESSOR, UNIVERSITY OF COLORADO COLLEGE OF NURSING 2017 TENTH
More informationDIRECT TRANSHEPATIC MEASUREMENT OF PORTAL VEIN PRESSURE USING A THIN NEEDLE
GASTROENTEROLOGY 72:584-589, 1977 Copyright 1977 by the American Gastroenterological Association Vol. 72, No.4, Part 1 Printed in U.S.A. DIRECT TRANSHEPATIC MEASUREMENT OF PORTAL VEIN PRESSURE USING A
More informationGENETIC AND SOMATIC EFFECTS OF IONIZING RADIATION
GENETIC AND SOMATIC EFFECTS OF IONIZING RADIATION United Nations Scientific Committee on the Effects of Atomic Radiation 1986 Report to the General Assembly, with annexes UNITED NATIONS New York, 1986
More informationPseudomonas aeruginosa Elastase Does Not Inactivate
INFECTION AND IMMUNITY, Dec. 1989, p. 3793-3797 0019-9567/89/123793-05$02.00/0 Copyright 1989, American Society for Microbiology Vol. 57, No. 12 Psedomonas aerginosa Elastase Does Not Inactivate ot1-proteinase
More information