Fall 2016 Pediatric Nutritional Products Guide

Transcription

1 Fall 2016 Pediatric Nutritional Products Guide Youll nurture her big dreams. Well help nurture her growing body.

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3 ABBOTT NUTRITION PEDIATRIC NUTRITIONAL PRODUCTS GUIDE WELCOME TO ABBOTT NUTRITION PEDIATRIC NUTRITIONALS This product guide provides a detailed nutritional overview of our products intended for infants and children. Our goal is to help you provide the best care for your patient by helping you with product selection. An electronic version of this guide is available at abbottnutrition.ca and is updated on a regular basis. Please refer to the product label for the most current information. Although every effort is made to ensure that all information is correct at the time of printing, values and instructions are subject to change. QUESTIONS OR COMMENTS Health care professionals can contact Abbott Nutrition Communications, a team of product specialists and registered dietitians, who can answer your product-related questions. Call: , option 1 canada.nutrition@abbott.com Service 7 days a week Weekdays 8 a.m. - 8 p.m., ET Weekends 10 a.m. - 4 p.m., ET ORDERING To order Abbott Nutrition products contact Customer Service. Call: , option 2 salesorder@abbott.com Monday Friday 8:30 a.m. - 5 p.m., ET Thank you for choosing Abbott Nutrition, a world leader in nutritional products for infants, children and adults. Your nutrition partner Like you, we care 3

4 TABLE OF CONTENTS GENERAL INFORMATION Abbott Nutrition Hospital Feeding System (HFS)...6 Indications for Use...7 Allergens...11 Infant Formula Preparation Guidelines and Dilution Charts...12 Recommended Storage Guidelines for Abbott Nutrition Products...13 Hang Time for Abbott Nutrition Infant and Pediatric Products...14 Expiration Dates...14 Warnings...14 Healthy Babies Begin with Healthy Moms...17 Caring for Our Tiniest Patients...23 Breast Milk - Inspiring Our Research and Innovation...47 Learn about scfos...89 Dosage Chart (Pedialyte ) PRODUCTS Pregnant Women and Breastfeeding Moms Similac Mom...18 Preterm Infants Similac Human Milk Fortifier Special Care 30 (with iron)...24 Similac Human Milk Fortifier...28 LiquiProtein...32 Similac Special Care 20 (with iron) (HFS)...34 Similac Special Care 24 (with iron) (HFS)...36 Similac Special Care 24 High Protein (with iron) (HFS)...38 Similac Neosure Omega-3 and Omega Similac Neosure Omega-3 and Omega-6 (HFS)...42 Term Infants Similac Advance Omega-3 and Omega-6 (Non-GMO)...48 Similac Advance Omega-3 and Omega-6 (Non-GMO) (HFS)...50 Similac Advance Omega-3 and Omega Similac Go & Grow Omega-3 and Omega-6 (Non-GMO)...54 Similac Go & Grow Omega-3 and Omega Similac Go & Grow...58 Similac Iron-Fortified...60 Step 2 products can be initiated from 6 months of age. Continued on next page 4

5 TABLE OF CONTENTS Term Infants (continued) Similac Lower Iron...62 Similac Partially Broken Down Protein...64 Similac Sensitive for babies sensitive to lactose...66 Similac Sensitive for babies sensitive to lactose (HFS)...68 Similac Isomil with Omega-3 and Omega Similac Isomil Omega-3 and Omega-6 (HFS)...72 Similac Isomil...74 Similac Isomil (Step 2)...76 Similac 24 with Iron (HFS)...78 Similac Alimentum Omega-3 and Omega Similac Alimentum...82 Similac Alimentum Omega-3 and Omega-6 (HFS)...84 Toddlers and Children PediaSure Complete Grow & Gain...90 PediaSure...92 PediaSure Fibre...94 PediaSure Plus (with fibre)...96 PediaSure Peptide 1 Cal...98 Specialty Products Pedialyte and Pedialyte Freezer Pops Pedialyte (HFS) Similac 5% Glucose Water (HFS) Similac Sterilized Water (HFS) RCF Accessories Component Nipple System Plastic Bottle and Cap CustomFeed Bottle and Volu-Feed Dispensing Cap Step 2 products can be initiated from 6 months of age. 5

6 ABBOTT NUTRITION HOSPITAL FEEDING SYSTEM (HFS) Abbott Nutrition provides a high quality, comprehensive line of hospital products featuring a variety of formulas, specialty products and nursing accessories. FOR HOSPITAL/INSTITUTIONAL USE ONLY. FEATURES Ready to use: formulas and specialty products in disposable, ready-to-feed nursing bottles. Convenience: eliminates bottle washing, formula mixing, sterilizing, refrigerating and warming. Safety: outstanding quality control more than 2000 quality-recommended checks are performed on each batch. Volume calibration (approximate) in ml: for more precise measurement, we recommend using a scaled volumetric container, particularly when the delivery amount is critical. Colour-matched bottle labels, inner trays and shipping cartons permit fast and accurate product identification. Economy: saves labour, space and equipment. AVAILABILITY See individual product listings. 6

7 INDICATIONS FOR USE Suggested indications do not replace the clinical judgment of the health care professional who is aware of the patient's complete medical history. Please note that this is not a complete listing of all possible products/uses and that the products in each category are not listed in order of preference. Allergy/Milk-Protein Sensitivity Similac Alimentum Similac Alimentum Omega-3 and Omega-6 When tolerance to soy has been established: Similac Isomil with Omega-3 and Omega-6 Similac Isomil Similac Isomil (Step 2) Human Milk Fortification Options Similac Human Milk Fortifier Special Care 30 (with iron) Similac Human Milk Fortifier LiquiProtein Burns (children 1-13 years of age) PediaSure PediaSure Fibre PediaSure Plus (with fibre) PediaSure Peptide 1 Cal Celiac Disease All Abbott Nutrition pediatric products are gluten-free with the exception of PediaSure Plus (with fibre). Colic Symptoms (due to cow s milk protein sensitivity) Similac Alimentum Similac Alimentum Omega-3 and Omega-6 Colitis Similac Alimentum Similac Alimentum Omega-3 and Omega-6 PediaSure Peptide 1 Cal Dehydration/Oral Hydration Pedialyte and Pedialyte Freezer Pops Continued on next page 7

8 INDICATIONS FOR USE Diarrhea Similac Sensitive for babies sensitive to lactose Similac Alimentum Similac Alimentum Omega-3 and Omega-6 PediaSure Peptide 1 Cal Pedialyte and Pedialyte Freezer Pops Failure to Thrive (children 1-13 years of age) PediaSure PediaSure Fibre PediaSure Plus (with fibre) PediaSure Complete Grow & Gain Fat Intolerance/Malabsorption Similac Alimentum Similac Alimentum Omega-3 and Omega-6 PediaSure Peptide 1 Cal Fussiness/Gas Similac Partially Broken Down Protein Similac Sensitive for babies sensitive to lactose Similac Isomil with Omega-3 and Omega-6 Similac Isomil Similac Isomil (Step 2) Similac Alimentum Similac Alimentum Omega-3 and Omega-6 Galactosemia Similac Isomil with Omega-3 and Omega-6 Similac Isomil Similac Isomil (Step 2) Powder is the preferred form for infants with galactosemia. Impaired Gastrointestinal Function Similac Alimentum Similac Alimentum Omega-3 and Omega-6 PediaSure Peptide 1 Cal Inborn Errors of Metabolism Similac Isomil with Omega-3 and Omega-6 Similac Isomil Similac Isomil (Step 2) RCF 8 Continued on next page

9 INDICATIONS FOR USE Kosher Abbott Nutrition pediatric products that are certified kosher have one of the following kosher indications, as applicable, on the product label or ingredient list: kosher and dairy by (U-D) and pareve by U Pareve. This information is also available in the TECHNICAL DATA section of each product in this guide. Lactose Intolerance/Sensitivity All Abbott Nutrition products, with the exception of Similac Isomil and our Specialty Products, contain some milk protein. With improvements in testing methodology, low levels of lactose in the products can now be detected. Most people with lactose intolerance can tolerate some amount of lactose in their diet. A review of the medical and scientific literature 1,2 suggests that most lactose intolerant patients could tolerate up to 6 g of lactose per serving. The products listed below contain less than 500 mg of lactose per serving and are therefore suitable for most people with lactose intolerance. Similac Mom Similac Partially Broken Down Protein Similac Sensitive for babies sensitive to lactose Similac Isomil with Omega-3 and Omega-6 Similac Isomil Similac Isomil (Step 2) Similac Alimentum Similac Alimentum Omega-3 and Omega-6 PediaSure PediaSure Fibre PediaSure Plus (with fibre) PediaSure Peptide 1 Cal PediaSure Complete Grow & Gain Picky Eating (i.e. feeding difficulties) PediaSure Complete Grow & Gain REFERENCES: 1. Suarez F. Abbott Nutrition Medical assessment of lactose tolerance in the lactose maldigesters population. April Hertzler SR, Huynh BC, Savaiano DA. How much lactose is low lactose? J Am Diet Assoc 1996;96: Continued on next page 9

10 INDICATIONS FOR USE Post-Operative Care (children 1-13 years of age) PediaSure PediaSure Fibre PediaSure Plus (with fibre) PediaSure Peptide 1 Cal PediaSure Complete Grow & Gain Premature/Low-Birth-Weight Infants Similac Human Milk Fortifier Special Care 30 (with iron) Similac Human Milk Fortifier LiquiProtein Similac Special Care 20 (with iron) (HFS) Similac Special Care 24 (with iron) (HFS) Similac Special Care 24 High Protein (with iron) (HFS) Similac Neosure Omega-3 and Omega-6 Protein Maldigestion Similac Alimentum Similac Alimentum Omega-3 and Omega-6 PediaSure Peptide 1 Cal Toddlers/Children Similac Go & Grow Omega-3 and Omega-6 (Non-GMO) Similac Go & Grow Omega-3 and Omega-6 Similac Go & Grow Similac Isomil (Step 2) PediaSure PediaSure Fibre PediaSure Plus (with fibre) PediaSure Peptide 1 Cal PediaSure Complete Grow & Gain Pedialyte and Pedialyte Freezer Pops 10

11 ALLERGENS Abbott Nutrition realizes the importance of product information for you and your patients, especially when managing allergies and intolerances. Priority food allergens and ingredients associated with intolerances and sensitivities are now listed following the ingredients list of each Abbott Nutrition product in this guide. The following foods or protein derived from one of these foods are considered priority food allergens in Canada: Peanuts Eggs Milk Mustard Tree nuts Wheat Soy Sesame seeds Seafood (refers to all edible fish, crustaceans and shellfish) Sulphites The following ingredients may be associated with food intolerances and/or sensitivities: Other soy components (components other than protein including soy oil, soy lecithin and soy fibre) Corn (in the form of maltodextrin, dextrose, corn syrup, corn starch and corn oil) Gluten Colours Flavours (natural and artificial) Citric acid Coconut oil Lactose The information contained in this guide was accurate at the time of publication. The most current information may be obtained by referring to product labels. For additional information on product ingredients related to food allergies and intolerances, please contact our team of product specialists and registered dietitians at , option 1. REFERENCE: Health Canada. Food Allergies ( 11

12 INFANT FORMULA PREPARATION GUIDELINES AND DILUTION CHARTS FOR HEALTH CARE PROFESSIONAL USE ONLY Hypocaloric and hypercaloric formulas should be used under medical supervision. Modifications (decrease/increase) of minerals and vitamins must be taken into consideration. Closer monitoring may be necessary. 27 Cal/30 ml or more calorically dense formula may not supply enough water for some infants. Hydration status should be monitored and water supplied from other sources if necessary. Gastrointestinal tolerance of hypo/hypercaloric formula may differ from standard dilution formula. Closer monitoring may be necessary. For improved tolerance, it is best to increase caloric density slowly, by 2- to 4-Cal/30 ml increments. Ready to use (cans and HFS bottles) Do not dilute. Concentrated Liquid (40 Cal/30 ml) Standard dilution (20 Cal/30 ml) is one part concentrated liquid to one part water. See back of product label for detailed preparation instructions. Caloric Density 1 Concentrated Water Final (Cal/30 ml) Liquid (ml) + (ml) = Volume (ml) 20 (standard) Powder Standard dilution (20 Cal/30 ml) is one level unpacked scoop of powder for each 60 ml of water. See product label for detailed preparation instructions. Caloric Density 1 (Cal/30 ml) Unpacked Level Scoop(s) + Water (ml) = Approximate Yield (ml) 20 (standard) Scoop Measurement and Displacement Volumes for Infant Powders Grams of Displacement Displacement powder per volume per volume per g of Product scoop scoop (ml) powder (ml) Preterm Infants Similac Neosure Omega-3 and Omega-6 Similac Human Milk Fortifier N/A N/A 0.69 Term Infants Similac Alimentum Omega-3 and Omega-6 Similac Advance Omega-3 and Omega-6 (Non-GMO) Similac Advance Omega-3 and Omega-6 Similac Iron-Fortified Similac Lower Iron Similac Sensitive for babies sensitive to lactose Similac Go & Grow Omega-3 and Omega-6 (Non-GMO) Similac Go & Grow Omega-3 and Omega-6 Similac Go & Grow Similac Isomil Similac Isomil with Omega-3 and Omega-6 Similac Isomil (Step 2) Similac Partially Broken Down Protein Use only scoop provided in the container. Values are approximate. Per 0.9 g packet. REFERENCE: 1. Adapted from Young T, Mangum B. Dilution Tables Neofax 17th ed. Raleigh NC 2004:

13 RECOMMENDED STORAGE GUIDELINES FOR ABBOTT NUTRITION PRODUCTS RECOMMENDED STORAGE TEMPERATURES FOR SEALED CONTAINERS Ready-to-use or concentrated liquid Most desirable: between 13 C and 24 C. Acceptable: between 0 C and 35 C. Do not freeze. Prolonged exposure to temperatures below 0 C or to direct heat above 35 C could affect the physical consistency of the product and consequently could also affect its appearance, flavour, and other sensory attributes. Product is sterile and should remain of sound nutritional quality. Powder Store in dry, cool area. Do not refrigerate. GUIDELINES FOR PREPARING AND STORING FORMULA 45 C 40 C 35 C 30 C 25 C 20 C 15 C 10 C 5 C 0 C -5 C -10 C -15 C Human Milk Fortifiers See individual product pages for storage information on Similac Human Milk Fortifier Special Care 30 (with iron), Similac Human Milk Fortifier, and LiquiProtein. Ready to use Cans and bottles: after opening, cover, refrigerate, and use within 48 hours. 945-mL reclosable plastic bottle: re-cap, refrigerate, and use within 72 hours. Concentrated Liquid Open can (undiluted): cover, refrigerate, and use within 48 hours. Prepare as per label instructions. Pour into individual feeding bottles or cups, cover, and store in refrigerator. Use prepared formula within 48 hours. Powder Prepare as per label instructions. Pour into individual feeding bottles or cups, cover, and store in refrigerator. Use within 24 hours. Cover opened container after each use. Use product within 1 month of opening container. If ready-to-use, undiluted or prepared formula is left at room temperature, it should be used within 2 hours. 1 Continued on next page 13

14 RECOMMENDED STORAGE GUIDELINES FOR ABBOTT NUTRITION PRODUCTS GUIDELINES FOR PREPARING AND STORING FORMULA (continued) If product is consumed directly or by straw from can or bottle: Infant formula Dispose of any product remaining in the bottle within 1 hour from beginning of feed (first time baby s mouth comes into contact with nipple). Do not reuse 59-mL (2-oz) plastic bottles. PediaSure products and Similac Mom (adult nutritional product) Use or refrigerate within 1 hour. If refrigerated, use product within 24 hours. HANG TIME FOR ABBOTT NUTRITION INFANT AND PEDIATRIC PRODUCTS Ready to use (commercially sterile) 4-8 hours when carefully poured from bottle/can into an enteral-feeding setup. 2 Reconstituted products Includes: Concentrated liquid, powder, any formula to which a modular component has been added, or human milk that has been fortified. Prepare using aseptic technique. Hang for no more than 4 hours. 2 Each health care facility is responsible for developing/ following procedures for using safe techniques in the preparation and use of tube feedings and in setting quality assurance protocols for monitoring those techniques. EXPIRATION DATES To assure the highest quality, use the formula by the date shown on the product. The vitamin content and the physical stability of the product cannot be guaranteed beyond the expiry date because both may degrade with time. WARNINGS Never use a microwave oven to warm formula; serious burns can result. Abbott Nutrition products are not intended for parenteral use. For highest quality product. This practice exposes the product to significant amounts of bacteria. REFERENCES: 1. Health Canada Preparing and Handling Powdered Infant Formula. Accessed on Robbins ST, Meyers R Infant feedings: Guidelines for Preparation of Human Milk and Formula in Health Care Facilities. 2nd eds. American Dietetic Assocation. Pediatric Nutrition Practice Group

15 PREGNANT WOMEN AND BREASTFEEDING MOMS Pregnant Women and Breastfeeding Moms IN THIS SECTION Similac Mom

16 Pregnant Women and Breastfeeding Moms PREGNANT WOMEN AND BREASTFEEDING MOMS

17 HEALTHY BABIES BEGIN WITH HEALTHY MOMS PREGNANT WOMEN AND BREASTFEEDING MOMS HAVE UNIQUE NUTRITIONAL NEEDS Healthy eating plays an important role in a healthy pregnancy. A balanced diet helps support both mom and baby s health and provides specific nutrients that are particularly important during pregnancy, including protein, iron, calcium, vitamin D, vitamin B12, and folic acid. Breast milk is the ideal food for babies, 1 and breastfeeding moms require optimal nutrition to ensure they have enough energy to give their baby their best. Similac Mom is the first and only nutritional beverage for pregnant women and breastfeeding moms, to help them meet their nutritional needs. For information on the complete Abbott Nutrition adult product line, visit us at abbottnutrition.ca or call , option 1, to speak to our team of product specialist and registered dietitians. REFERENCE: 1. Health Canada, Canadian Paediatric Society, Dietitians of Canada, & Breastfeeding Committee for Canada (2014). Nutrition for healthy term infants: Recommendations from birth to six months. 17

18 SIMILAC MOM Complete, balanced nutrition For pregnant women and breastfeeding moms INDICATIONS FOR USE For pregnant or breastfeeding women: - who would benefit from a nutritious snack. - with increased caloric needs. - who require increased protein, vitamins and minerals. To be used as part of an overall healthy diet that includes following doctor s recommendations for using prenatal vitamins. For use with or between meals or, in appropriate amounts, as a meal replacement. For oral feeding only not for tube feeding. Safety precautions: Not for parenteral use. Not for people with galactosemia. Not intended for use in infants or children. FEATURES AND BENEFITS Complete, balanced nutrition. Provides 26 vitamins and minerals. Contains 1166 IU of vitamin A per bottle. Contains calcium, vitamin D, iron, folic acid and other essential vitamins and minerals. Convenient source of protein and energy to help meet the increased needs of pregnant women and breastfeeding moms. Convenient, reclosable bottle. 2 delicious flavours: vanilla and chocolate. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 0.96 Protein (% of total energy) 21 Fat (% of total energy) 24 Carbohydrate (% of total energy) 55 Total Cal:g nitrogen ratio 122:1 Non-protein Cal:g nitrogen ratio 96:1 Water (g/l) 837 Osmolality (mosm/kg water) 546 Renal solute load (mosm/l) 417 Viscosity at room temperature/ Thin/thin chilled Minimum tube size for gravity/ N/A pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Similac Mom, Vanilla 235-mL bottles 4 x 6/case Similac Mom, Chocolate 235-mL bottles 4 x 6/case 18

19 ENERGY Per 235 ml Per 100 ml ENERGY (Cal [kj]) 225 (945) 96 (402) PROTEIN (g) % of total energy 21 Arginine (mg) - - Taurine (mg) - - Carnitine (mg) - - Sodium and calcium caseinates, soy protein isolate FAT (g) % of total energy 24 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) - - Linolenic acid (g) Docosahexaenoic acid (DHA) (g) - - Omega-6:Omega-3 ratio 7.4:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High Oleic safflower oil, canola oil, corn oil, soy lecithin MCT oil (% of total fats) 0 CARBOHYDRATE (g) % of total energy 55 Total dietary fibre (g) - - Short-chain fructooligosaccharides - - (scfos) (g) Galactooligosaccharides (GOS) (g) - - Sucrose, corn maltodextrin Acesulfame-potassium (mg) - - Sucralose (mg) - - VITAMINS Vitamin A (RE [IU]) 350 (1166) 149 (496) Vitamin D3 (mcg [IU]) 1.25 (50) 0.53 (21.3) Vitamin E (IU) Vitamin K1 (mg) - - Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) - - MINERALS Sodium (mg [mmol]) 290 (12.6) 123 (5.3) Potassium (mg [mmol]) 428 (11.0) 182 (4.7) Chloride (mg [mmol]) 251 (7.1) 107 (3.0) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodide (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION Nutritional information for Similac Mom, Vanilla, 235 ml. INGREDIENTS Similac Mom, Vanilla: Water, sugar, sodium and calcium caseinates, corn maltodextrin, high oleic safflower oil, canola oil, soy protein isolate, corn oil, potassium citrate, sodium citrate, calcium phosphate, magnesium phosphate, natural and artificial flavour, magnesium chloride, salt, soy lecithin, potassium phosphate, carrageenan, ascorbic acid, zinc sulphate, ferrous sulphate, niacinamide, dl-α-tocopheryl acetate, manganese sulphate, cupric sulphate, calcium pantothenate, vitamin A palmitate, pyridoxine hydrochloride, thiamine chloride hydrochloride, riboflavin, folic acid, potassium iodide, sodium molybdate, biotin, sodium selenate, chromium chloride, vitamin D3, cyanocobalamin. CONTAINS: Priority food allergens: Milk, soy. Ingredients associated with food intolerances and/ or sensitivities: Corn, coconut oil, natural and artificial flavour, lactose, and other soy components. Additional ingredients for chocolate: Cocoa powder, colour. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC MOM Complete, balanced nutrition For pregnant women and breastfeeding moms

20 NOTES:

21 PRETERM INFANTS Preterm Infants IN THIS SECTION Similac Human Milk Fortifier Special Care 30 (with iron) Similac Human Milk Fortifier LiquiProtein Similac Special Care 20 (with iron) (HFS) Similac Special Care 24 (with iron) (HFS) Similac Special Care 24 High Protein (with iron) (HFS) Similac Neosure Omega-3 and Omega-6 Similac Neosure Omega-3 and Omega-6 (HFS)

22 Preterm Infants PRETERM INFANTS

23 CARING FOR OUR TINIEST PATIENTS ABBOTT NUTRITION - GIVING HEALTH CARE PROVIDERS THE POWER TO DO MORE Without the chance to develop fully in utero, infants born prematurely are physiologically different from term infants. Early nutrition is a key factor in their survival. Each preterm baby has individual needs, and these needs vary over time after birth. Human milk is the feeding of choice for preterm infants. However, neither human milk nor term infant formulas provide preterm and low-birth-weight babies with the necessary levels of nutrients for catch-up growth and optimal development. Human milk, once supplemented with human milk fortifier, provides adequate amounts of energy and most nutrients, with the exception of protein, which oftentimes requires additional supplementation. 1 To help you meet the unique and varied nutritional needs of preterm infants, Abbott Nutrition has developed a wide range of infant nutritional products, including the most comprehensive line of human milk fortification options: 1) Human milk fortification options Similac Human Milk Fortifier Special Care 30 (with iron) Unique to Abbott Nutrition Similac Human Milk Fortifier LiquiProtein Unique to Abbott Nutrition 2) Preterm formulas, available in various caloric and protein densities Similac Special Care 20 (with iron) Similac Special Care 24 (with iron) Similac Special Care 24 High Protein (with iron) 3) Preterm, post-discharge formula Similac Neosure Omega-3 and Omega-6 Follow hospital guidelines for handling of human milk. REFERENCE: 1. Koletzko B, Poindexter B, Uauy R (eds): Nutritional Care of Preterm Infants: Scientific Basis and Practical Guidelines. World Rev Nutr Diet. Basel, Karger, 2014, vol 110, pp

24 SIMILAC HUMAN MILK FORTIFIER SPECIAL CARE 30 (WITH IRON) Liquid Human Milk Fortifier For preterm or low birth weight infants INDICATIONS FOR USE For preterm or low-birth-weight infants who are nourished with human milk and require fortification to meet their high nutritional needs. - If mother s milk supply is limited, a liquid human milk fortifier may be used to extend the human milk volume. 1 For use with human milk. For oral or tube feeding use. Safety precautions: Use under medical supervision. For hospital use. Follow hospital rules for safe handling of human milk. Once tolerance to enteral feeding with human milk is wellestablished, Similac Human Milk Fortifier Special Care 30 (with iron) can be added to human milk. If signs of intolerance develop, slow feeding or discontinue. Not intended for feeding premature infants after they reach a weight of approximately 3600 g (approximately 8 lb) unless otherwise directed by the health care professional. Not for parenteral use. FEATURES AND BENEFITS Sterile liquid formulation. - Easy to mix. - Safer choice for preterm and low-birth-weight infants under 2 months of age or immunocompromised infants. 2,3 - When available, liquid human milk fortifiers are preferable to powders because they are sterile. 4 - Short-term weight gain and tolerance similar to babies fed human milk supplemented with Similac Human Milk Fortifier powder. 5 When mixed 1:1 with human milk: - Provides 25 Cal/30 ml (84 Cal/100 ml) to meet the energy needs of most preterm infants. 5,6 - Increases the calcium and phosphorus content of human milk to support growing bones. 6,7 - Nearly isotonic (310 mosm/kg water) helping optimize the nutrient content of human milk without increasing osmolality. Contains DHA, an omega-3 fatty acid, and ARA, an omega-6 fatty acid (0.25% and 0.4% of total fatty acids respectively) to support the normal physical development of the brain and eyes. TECHNICAL DATA Ready to mix Caloric density (Cal/mL) 1.01 Protein (% of total energy) 12.0 Fat (% of total energy) 57.1 Carbohydrate (% of total energy) 30.9 Total Cal:g nitrogen ratio 209:1 Non-protein Cal:g nitrogen ratio 184:1 Water (g/l) 850 Osmolality (mosm/kg water) 325 Renal solute load (mosm/l) 282 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ N/A pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to mix 59439A71 Similac Human Milk Fortifier 59-mL plastic 48/case Special Care 30 (with iron) bottles 24

25 ENERGY Ready to mix Per 100 ml Ready to mix Per 59 ml ENERGY (Cal [kj]) 101 (424) 60 (251) PROTEIN (g) % of total energy 12.0 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Skim milk, whey protein concentrate FAT (g) % of total energy 57.1 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega 6:Omega 3 ratio 6.35:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) Medium chain triglycerides (modified coconut oil and/ or palm kernel oil), soy oil, coconut oil MCT oil (% of total fats) 49.2 CARBOHYDRATE (g) % of total energy 30.9 Total dietary fibre (g) - - Short-chain fructooligosaccharides - - (scfos) (g) Galactooligosaccharides (GOS) (g) - - Corn syrup solids, lactose Acesulfame-potassium (mg) - - Sucralose (mg) - - VITAMINS Vitamin A (RE [IU]) 380 (1268) 224 (748) Vitamin D3 (mcg [IU]) 3.80 (152) 2.24 (90) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) 10 6 Inositol (mg) Lutein (mg) - - MINERALS Sodium (mg [mmol]) 44 (1.91) 26 (1.13) Potassium (mg [mmol]) 131 (3.36) 77 (1.98) Chloride (mg [mmol]) 82 (2.31) 48 (1.36) Calcium (mg) Phosphorus (mg) Magnesium (mg) 12 7 Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) - - Molybdenum (mg) - - INGREDIENTS Similac Human Milk Fortifier Special Care 30 (with iron), Ready to mix: Water, skim milk, corn syrup solids, medium chain triglycerides (modified coconut oil and/or palm kernel oil), soy oil, whey protein concentrate, coconut oil, lactose, MINERALS: (calcium phosphate, calcium carbonate, magnesium chloride, sodium citrate, potassium hydroxide, ferrous sulphate, zinc sulphate, cupric sulphate, potassium citrate, manganese sulphate, sodium selenate), VITAMINS: (ascorbic acid, m-inositol, choline bitartrate, choline chloride, niacinamide, d-α-tocopheryl acetate, d-calcium pantothenate, vitamin A palmitate, riboflavin, thiamine chloride hydrochloride, pyridoxine hydrochloride, folic acid, β-carotene, biotin, phylloquinone, vitamin D3, cyanocobalamin), soy lecithin, monoglycerides, *M. alpina oil, **C. cohnii oil, carrageenan, taurine, L-carnitine, cytidine 5'-monophosphate, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate, adenosine 5'-monophosphate. May contain potassium phosphate and potassium chloride. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, lactose, and other soy components. NUTRITIONAL INFORMATION Continued on next page

26 PREPARATION INSTRUCTIONS Proper hygiene, handling and storage are important when preparing infant feedings. 1) Pour desired quantity of human milk into a clean container. 2) Measure an equal volume of Similac Human Milk Fortifier Special Care 30 (with iron). 3) Add to human milk and gently swirl to mix. 4) Warm as per usual nursery practices. 5) Cover and refrigerate unused liquid fortifier after opening; use within 24 hours or discard. 6) If fortified human milk is not used immediately, cover prepared mixture and store in refrigerator. Use within 24 hours 4 or according to hospital procedure. 7) Once feeding begins, use within one hour or discard. 8) For tube feedings, hang for no more than 4 hours. 4 REFERENCES: 1. Adamkin DH, Radmacher PG. Fortification of Human Milk in Very Low Birth Weight Infants (VLBW <1500 g Birth Weight). Clin Perinatol 41 (2014) Health Canada. Nutrition for Healthy Term Infants: Recommendations from Birth to Six Months. Accessed at nutrition/infant-nourisson/recom/index-eng.php#a11. Accessed on April 7, Government of Canada. Preparing and handling powdered infant formula. Accessed at gc.ca/eating-nutrition/safety-salubrite/formula-nourrisson-eng.php. Accessed on July 24, Robbins ST and Myers R (eds). Infant Feedings: Guidelines for Preparation of Human Milk and Formula in Health Care Facilities. 2nd ed. American Dietetic Assocation. Pediatric Nutrition Practice Group Lewis J et al. J Invest Med. 2010;58(2):435. Abstract Klein CJ. J Nutr 2002;132:1395S- 1577S. 7. Koletzko B, Poindexter B, Uauy R (eds): Nutritional Care of Preterm Infants: Scientific Basis and Practical Guidelines. World Rev Nutr Diet. Basel, Karger, 2014, vol 110, pp Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC HUMAN MILK FORTIFIER SPECIAL CARE 30 (WITH IRON) Liquid Human Milk Fortifier 3For preterm or low birth weight infants

27 Comparison of Preterm Human Milk (PTHM) + Similac Human Milk Fortifier Special Care 30 (with iron) (SHMF SC30 w/iron) to Key Nutrient Requirements ENERGY Key Nutrient Requirements per 100 Cal* Min Max ENERGY (Cal [kj]) 100 (418) 100 (418) Volume (ml) - - PROTEIN (g) FAT (g) CARBOHYDRATE (g) VITAMINS Vitamin A (RE[IU]) 210 (700) 376 (1254) Vitamin D3 (mcg [IU]) 1.88 (75) 6.75 (270) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) 8 37 Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) 7 23 Inositol (mg) 4 44 MINERALS Sodium (mg [mmol]) 39 (1.70) 63 (2.74) Potassium (mg [mmol]) 60 (1.54) 160 (4.10) Chloride (mg [mmol]) 60 (1.69) 160 (4.51) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) ENERGY Preterm Human Milk per PTHM + SHMF SC30 w/iron 1:1 ratio 100 Cal 1 Per 100 Cal Per 100 ml ENERGY (Cal [kj]) 100 (418) 100 (418) 84 (351) Volume (ml) PROTEIN (g) FAT (g) CARBOHYDRATE (g) VITAMINS Vitamin A (RE[IU]) 174 (581) 295 (984) 249 (829) Vitamin D3 (mcg [IU]) 0.08 (3) 2.28 (91) 1.93 (77) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) 37 (1.61) 41 (1.78) 34 (1.48) Potassium (mg [mmol]) 85 (2.18) 111 (2.85) 94 (2.41) Chloride (mg [mmol]) 82 (2.31) 81 (2.28) 69 (1.95) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) * Life Sciences Research Office recommendations for preterm and low-birth-weight infants. 2 NOTE: These guidelines are designed for preterm infant formulas, NOT fortified human milk. Thus, these recommendations can serve only as a general guideline relative to fortified human milk. The nutrient concentrations listed for preterm human milk are mean human milk levels. The range of nutrients in preterm human milk is highly variable. REFERENCES: 1. Meeting the Special Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, Ohio: Abbott Nutrition, Abbott Laboratories, January 1998, p Klein CJ: Nutrient requirements for preterm infant formulas. J Nutr 2002;1395S-1577S. 4 27

28 SIMILAC HUMAN MILK FORTIFIER For preterm or low-birth-weight infants INDICATIONS FOR USE For preterm or low-birth-weight infants nourished with human milk that requires fortification to meet elevated nutrient requirements. Intended as a nutritional supplement to add to human milk. For oral or tube feeding use. Safety precautions: Use under medical supervision. For infants who are premature, low-birth-weight or with a weakened immune system, sterile liquids are preferred. 1 This product is not sterile and should only be used as directed by a health care professional. Tolerance to enteral feedings should be confirmed by offering small volumes of unfortified human milk. Once enteral feeding is well-established, Similac Human Milk Fortifier can be added to human milk. Not intended for feeding low-birth-weight infants after they reach a weight of 3600 g (approximately 8 lb) unless otherwise directed by a health care professional. Add only to human milk do not add water. Not for parenteral use. FEATURES AND BENEFITS Peer-reviewed studies have demonstrated: - Normal weight, length and head circumference gains in preterm infants. 2 - Preserved antibacterial activity of human milk against Escherichia coli, Staphylococcus, Group B Streptococcus, and Enterobacter sakazakii (now Cronobacter sakazakii). 3 Low iron content provides flexibility to add iron as needed. Mixes readily with human milk. Small, convenient packaging. TECHNICAL DATA Preterm Human Milk + Similac Human Milk Fortifier (50 ml g powder) Caloric density (Cal/mL) 0.73 Protein (% of total energy) 10 Fat (% of total energy) 49 Carbohydrate (% of total energy) 41 Total Cal:g nitrogen ratio 250:1 Non-protein Cal:g nitrogen ratio 57:43 Water (g/l) 867 Osmolality (mosm/kg water) 343 Renal solute load (mosm/l) Viscosity at room temperature/ - chilled Minimum tube size for gravity/ N/A pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Powder Similac Human Milk Fortifier 50 x 0.9 g 3 inner cartons/ packets/ case 28

29 PREPARATION AND USE The health of the infant depends on carefully following the directions for preparation and use. Proper hygiene, handling and storage are important when preparing infant feedings. Similac Human Milk Fortifier Mixing Chart Additional Preterm Human Similac Cal desired Milk Milk Fortifier Human For initiation 2 Cal/30 ml 50 ml 1 packet (0.9 g) For full strength feeding 4 Cal/30 ml 25 ml 1 packet (0.9 g) 1. It is recommended that human milk be fortified just prior to feeding Shake container of human milk. If frozen, thaw according to hospital procedure. 3. To promote optimal mixing, human milk should be slightly above room temperature before adding the fortifier. 4. Pour desired quantity of human milk into sterile container; add Similac Human Milk Fortifier (as per mixing chart). 5. Shake gently and feed. 6. Bottle feeding: Discard any remaining product in the bottle within 1 hour after feeding begins. Tube feeding: Hang for no more than 4 hours. 5 STORAGE Cover and refrigerate unused fortified human milk immediately and use within 24 hours. Store unopened packets at room temperature; avoid extreme temperatures. ENERGY Per 1 packet (0.9 g) Per 4 packets (3.6 g) ENERGY (Cal [kj]) 3.5 (14.7) 14 (59) PROTEIN (g) Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) - - Carnitine (mg) - - Nonfat milk, whey protein concentrate FAT (g) Linoleic acid (g) - - MCT oil CARBOHYDRATE (g) Corn syrup solids VITAMINS Vitamin A (RE [IU]) 47 (155) 186 (620) Vitamin D3 (mcg [IU]) 0.75 (30) 3 (120) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) 3.8 (0.16) 15 (0.65) Potassium (mg [mmol]) 15.8 (0.4) 63 (1.62) Chloride (mg [mmol]) 9.5 (0.27) 38 (1.07) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) - - Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) - - Molybdenum (mg) - - INGREDIENTS Similac Human Milk Fortifier, Powder: Nonfat milk, whey protein concentrate, corn syrup solids, medium chain triglycerides (modified coconut oil and/or palm kernel oil), calcium phosphate, potassium citrate, ascorbic acid, magnesium chloride, soy lecithin, sodium chloride, zinc sulphate, m-inositol, niacinamide, sodium citrate, d-α-tocopheryl acetate, calcium pantothenate, ferrous sulphate, vitamin A palmitate, cupric sulphate, riboflavin, thiamine chloride hydrochloride, pyridoxine hydrochloride, vitamin D3, biotin, folic acid, manganese sulphate, phylloquinone, cyanocobalamin, sodium selenate. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Coconut oil, lactose, other soy components. NUTRITIONAL INFORMATION Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC HUMAN MILK FORTIFIER For preterm and low-birth-weight infants

30 Preterm Human Milk (PTHM) + Similac Human Milk Fortifier Per 100 Cal ENERGY 30 Preterm Human Milk PTHM + Similac Human Milk Fortifier 50 ml + 1 packet 25 ml + 1 packet ENERGY (Cal) Volume (ml) PROTEIN (g) % of total energy Preterm human milk Preterm human milk, nonfat milk, whey protein concentrate FAT (g) % of total energy Preterm human milk Preterm human milk, medium chain triglycerides Linoleic acid (g) CARBOHYDRATE (g) % of total energy Lactose Lactose, corn syrup solids VITAMINS Vitamin A (RE [IU]) 174 (581) 283 (944) 374 (1245) Vitamin D3 (mcg [IU]) 0.08 (3) 2.1 (84) 3.75 (150) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) 37 (1.6) 44 (1.9) 49 (2.1) Potassium (mg [mmol]) 85 (2.2) 119 (3.1) 148 (3.8) Chloride (mg [mmol]) 82 (2.3) 100 (2.8) 115 (3.2) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) OTHER CHARACTERISTICS PRSL (mosm/l) Water (g) Osmolality (mosm/kg water) Per 1000 ml ENERGY Preterm Human Milk PTHM + Similac Human Milk Fortifier 50 ml + 1 packet 25 ml + 1 packet ENERGY (Cal) Volume (ml) PROTEIN (g) % of total energy Preterm human milk Preterm human milk, nonfat milk, whey protein concentrate FAT (g) % of total energy Preterm human milk Preterm human milk, medium chain triglycerides Linoleic acid (g) CARBOHYDRATE (g) % of total energy Lactose Lactose, corn syrup solids VITAMINS Vitamin A (RE [IU]) 1170 (3899) 2072 (6906) 2950 (9834) Vitamin D3 (mcg [IU]) 0.5 (20) 15.3 (612) 29.7 (1188) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg)

31 Per 1000 ml MINERALS Preterm Human Milk PTHM + Similac Human Milk Fortifier 50 ml + 1 packet 25 ml + 1 packet Sodium (mg [mmol]) 248 (10.8) 319 (13.9) 388 (16.9) Potassium (mg [mmol]) 570 (14.6) 874 (22.4) 1169 (30) Chloride (mg [mmol]) 550 (15.5) 730 (20.6) 906 (25.6) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) OTHER CHARACTERISTICS PRSL (mosm/l) Water (g) Osmolality (mosm/kg water) NUTRITIONAL INFORMATION The nutrient concentrations listed for preterm human milk are mean human milk levels. The range of nutrients in preterm human milk is highly variable. 6 Values for term human milk have been used for linoleic acid, biotin, choline, inositol, manganese, iodine, and selenium. 7 REFERENCES: 1. Government of Canada. Preparing and handling powdered infant formula. Accessed at healthycanadians.gc.ca/eating-nutrition/safety-salubrite/formula-nourrisson-eng.php. Accessed on July 24, Barrett-Reis B, Hall RT, Schanler RJ, et al. Pediatrics. 2000; 106: Chan GM. J Perinatol. 2003;23: Reali A, Greco F, Fanaro S, et al. Early Hum Dev 2010;86:S Robbins ST and Myers R (eds). Infant Feedings: Guidelines for Preparation of Human Milk and Formula in Health Care Facilities. 2nd ed. American Dietetic Assocation. Pediatric Nutrition Practice Group Meeting the Special Nutrient Needs of Low-Birth-Weight and Premature Infants in the Hospital (A8100). Columbus, Ohio: Abbott Nutrition, Abbott Laboratories, January 1998, p American Academy of Pediatrics Committee on Nutrition: Pediatric Nutrition Handbook, 4th ed. Elk Grove Village: American Academy. 4 31

32 LIQUIPROTEIN Extensively Hydrolyzed Protein INDICATIONS FOR USE For use as a fortifier for human milk or infant formula. For preterm infants with increased protein needs. Safety precautions: Not for use as a sole source of nutrition. Use as directed by a health care professional. Do not attach nipple or feed directly. If signs of intolerance develop, slow feeding or discontinue. Not for parenteral use. FEATURES AND BENEFITS A commercially sterile, extensively hydrolyzed liquid protein modular; same trusted casein hydrolysate used in Similac Alimentum. Eliminates the need for protein powder mixing and meets Health Canada 1 and other expert body recommendations 2,3 to reduce the risk of contamination. Allows for customized protein intake. Safe for preterm infants study 5 indicates good feeding tolerance and growth when fed full strength fortified human milk with the addition of LiquiProtein.** Minimal impact on osmolality; 1 ml contributes ~12 mosm/kg water when 100 ml feeding is prepared; osmolality comparable to using Similac Human Milk Fortifier. Black cap for easy product identification and distinguishing features on label designed to stand out from infant formulas. Lactose-free TECHNICAL DATA Ready to mix Caloric density (Cal/mL) 0.67 Protein (% of total energy) 100 Fat (% of total energy) 0 Carbohydrate (% of total energy) 0 Total Cal:g nitrogen ratio 25:1 Non-protein Cal:g nitrogen ratio N/A Water (g/l) 810 Displacement 1 ml will displace 1 ml of feeding Osmolality Preterm infants Osmolality per 100 ml feeding 1 ml contributes ~12 mosm/kg water Osmolality as commonly fed mosm/kg water Renal solute load (mosm/l) - Viscosity at room temperature/ - chilled Minimum tube size for gravity/ N/A pump feeding (Fr) Low residue Gluten-free Kosher Halal No No AVAILABILITY Ready to mix 62317X31(Pediatric) LiquiProtein 54-mL plastic 48/case bottles ** 25 ml human milk + 1 packet Similac Human Milk Fortifier + 1 ml LiquiProtein. Osmolality when supplementing 25 ml of preterm human milk with an equivalent of 0.25 g of protein from the following products: 1 packet Similac Human Milk Fortifier: 385 mosm/kg water; 1.5 ml LiquiProtein : 370 mosm/kg water. 1 to 6 ml of LiquiProtein + human milk, fortified human milk or formula; total volume of 100 ml. 32

33 PREPARATION The health of the infant depends on carefully following the directions for preparation and use. Proper hygiene, handling and storage are important when preparing infant feedings. It is recommended that human milk be fortified just prior to feeding. 4 Do not add water 1. Pour LiquiProtein into a medicine cup. 2. Using a single use oral syringe, draw up volume specified by a health care professional. 3. Dispense into measured human milk or formula and mix gently. Pour desired amount of mixture into feeding container. STORAGE Store unopened at room temperature; avoid extreme temperatures. Once opened, refrigerate and use within 72 hours. When mixed with human milk or formula, cover and refrigerate unused mixture immediately. Use within 24 hours or according to normal hospital procedure. For preterm infants who are tube-fed, fortified milk can remain safely at room temperature (25 C) for up to 4 hours. 2 ENERGY Per 6 ml Per 54 ml ENERGY (Cal [kj]) 4 (17) 35 (149) PROTEIN (g) 1 9 % of total energy 100 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Casein hydrolysate MINERALS Sodium (mg) 5 50 INGREDIENTS LiquiProtein, ready-to-mix liquid: Water, casein hydrolysate (derived from milk). CONTAINS: Priority food allergens: Milk ingredients. NUTRITIONAL INFORMATION Other inherent minerals may be present in trace amounts. LiquiProtein contains the same trusted casein hydrolysate as used in Similac Alimentum. REFERENCES: 1. Government of Canada. Healthy Canadians: Preparing and Handling Powdered Infant Formula. [updated 2012, January 12; cited 2013, September 26]. Available from: gc.ca/kids-enfants/food-aliment/formula-nourrisson-eng.php 2. Robbins ST, Meyers R eds. Infant Feedings: Guidelines for Preparation of Human Milk and Formula in Health Care Facilities. 2nd ed. Chicago, IL. American Dietetic Association. Pediatric Nutrition Practice Group. 2011: Bankhead R et al. A.S.P.E.N. Enteral Nutrition Practice Recommendations. J Parenter Enteral Nutr 2009;33(122): Reali A, Greco F, Fanaro S et al. Fortification of maternal milk for very low birth weight (VLBW) pre-term neonates. Early Hum Dev 2010;86:S Shakeel F et al. [ABSTRACT]. JPGN September 2015;61(Suppl 2);S112. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. LIQUIPROTEIN Extensively Hydrolyzed Protein

34 SIMILAC SPECIAL CARE 20 (WITH IRON) DHA- and ARA-enriched formula For preterm infants INDICATIONS FOR USE For infants who are born prematurely and have additional nutrient needs that were not met in-utero. Recommended until infant reaches 3600 g (approximately 8 lb). For oral or tube feeding use. Safety precautions: Use under medical supervision. Not intended for feeding preterm infants after they reach a weight of 3600 g, or as directed by a physician. If signs of intolerance develop, slow feeding or discontinue. Not for parenteral use. FEATURES AND BENEFITS Higher levels of protein, electrolytes, vitamins and minerals per 100 Cal than standard term formula to provide preterm babies with the nutrients they need for growth and development. Calcium and phosphorus at concentrations and ratio (1.8:1) that support intrauterine accretion rates. 1 Approximately 2 mg iron/kg body weight per day when fed at 120 Cal/kg/day. Approximately 40% of fat as medium-chain triglycerides, an easily digested and well-absorbed fat source. 2 Contains DHA (0.25% ), an Omega-3 fatty acid, and ARA (0.4% ), an Omega-6 fatty acid, to support the normal physical development of the brain and eyes. Unique blend of nucleotides (72 mg/l). No palm olein oil. Easy to digest. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 0.68 Protein (% of total energy) 12.0 Fat (% of total energy) 46.7 Carbohydrate (% of total energy) 41.3 Total Cal:g nitrogen ratio 213:1 Non-protein Cal:g nitrogen ratio 187:1 Water (g/l) 900 Osmolality (mosm/kg water) 238 Renal solute load (mosm/l) 180 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ N/A pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Similac Special Care mL plastic 48/case (with iron) bottles Of total fatty acids. Similar to other infant formulas. REFERENCES: 1. Mize et al. Am J Clin Nutr 1995;62: Duggan C, Watkins JB and Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton

35 ENERGY Per 100 ml Per 100 Cal Per 59 ml ENERGY (Cal [kj]) 68 (284) 100 (418) 40 (168) PROTEIN (g) % of total energy 12.0 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides Dry skim milk, whey protein concentrate FAT (g) % of total energy 46.7 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 7.22:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) MCT oil, soy oil, coconut oil, high oleic sunflower oil, ARA and DHA MCT oil (% of total fats) 39.5 CARBOHYDRATE (g) % of total energy 41.3 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Corn maltodextrin, lactose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 140 (467) 206 (687) 83 (276) Vitamin D3 (mcg [IU]) 2.6 (102) 3.8 (150) 1.5 (60) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) 29 (1.26) 43 (1.85) 17 (0.74) Potassium (mg [mmol]) 94.5 (2.42) (3.56) 55.8 (1.43) Chloride (mg [mmol]) 55 (1.55) 81 (2.28) 32 (0.92) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION INGREDIENTS Similac Special Care 20 (with iron), Ready to use: Water, corn maltodextrin, dry skim milk, lactose, medium chain triglycerides (modified coconut and/ or palm kernel oils), whey protein concentrate, soy oil, coconut oil, high oleic sunflower oil, calcium phosphate, sodium citrate, ascorbic acid, soy lecithin, monoglycerides, *M. alpina oil, carrageenan, magnesium chloride, potassium chloride, **C. cohnii oil, calcium carbonate, m-inositol, potassium citrate, potassium hydroxide, ferrous sulphate, taurine, choline bitartrate, L-carnitine, choline chloride, dl-α-tocopheryl acetate, cytidine 5'-monophosphate, zinc sulphate, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate, adenosine 5'-monophosphate, calcium pantothenate, niacinamide, vitamin A palmitate, cupric sulphate, riboflavin, thiamine hydrochloride, pyridoxine hydrochloride, folic acid, phylloquinone, manganese sulphate, sodium selenite, biotin, vitamin D3, cyanocobalamin. May contain sodium chloride, potassium phosphate. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, lactose, and other soy components. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC SPECIAL CARE 20 (WITH IRON) DHA- and ARA-enriched formula For preterm infants

36 SIMILAC SPECIAL CARE 24 (WITH IRON) Hypercaloric, DHA- and ARA-enriched formula For preterm infants INDICATIONS FOR USE For infants who are born prematurely and have additional nutrient needs that were not met in-utero. Recommended until infant reaches 3600 g (approximately 8 lb). For oral or tube feeding use. Safety precautions: Use under medical supervision. Not intended for feeding preterm infants after they reach a weight of 3600 g, or as directed by a physician. If signs of intolerance develop, slow feeding or discontinue. Not for parenteral use. FEATURES AND BENEFITS Increased caloric density: provides 81 Cal per 100 ml (24 Cal/30 ml). Higher levels of protein, electrolytes, vitamins and minerals per 100 Cal than standard term formula to provide preterm babies with the nutrients they need for growth and development. Calcium and phosphorus at concentrations and ratio (1.8:1) that support intrauterine accretion rates. 1 Approximately 2 mg iron/kg body weight per day when fed at 120 Cal/kg/day. Approximately 40% of fat as medium-chain triglycerides, an easily digested and well-absorbed fat source. 2 Contains DHA (0.25% ), an Omega-3 fatty acid, and ARA (0.4% ), an Omega-6 fatty acid, to support the normal physical development of the brain and eyes. Unique blend of nucleotides (72 mg/l). No palm olein oil. Easy to digest. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 0.81 Protein (% of total energy) 12.0 Fat (% of total energy) 46.7 Carbohydrate (% of total energy) 41.3 Total Cal:g nitrogen ratio 213:1 Non-protein Cal:g nitrogen ratio 187:1 Water (g/l) 880 Osmolality (mosm/kg water) 300 Renal solute load (mosm/l) 210 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ N/A pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Similac Special Care mL plastic 48/case (with iron) bottles Of total fatty acids. Similar to other infant formulas. REFERENCES: 1. Mize et al. Am J Clin Nutr 1995;62: Duggan C, Watkins JB and Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton

37 ENERGY Per 100 ml Per 100 Cal Per 59 ml ENERGY (Cal [kj]) 81 (339) 100 (418) 48 (201) PROTEIN (g) % of total energy 12.0 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides Dry skim milk, whey protein concentrate FAT (g) % of total energy 46.7 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 7.29:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) MCT oil, soy oil, coconut oil, high oleic sunflower oil, ARA and DHA MCT oil (% of total fats) 39.5 CARBOHYDRATE (g) % of total energy 41.3 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Corn maltodextrin, lactose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 167 (556) 206 (687) 98 (328) Vitamin D3 (mcg [IU]) 3.05 (122) 3.77 (151) 1.80 (72) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) 35 (1.52) 43 (1.88) 21 (0.90) Potassium (mg [mmol]) 113 (2.90) 140 (3.58) 67 (1.71) Chloride (mg [mmol]) 66 (1.86) 81 (2.30) 39 (1.10) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION INGREDIENTS Similac Special Care 24 (with iron), Ready to use: Water, corn maltodextrin, dry or condensed milk, lactose, medium chain triglycerides (modified coconut and/or palm kernel oils), whey protein concentrate, soy oil, coconut oil, high oleic sunflower oil, calcium phosphate, sodium citrate, ascorbic acid, soy lecithin, monogly cerides, *M. alpina oil, potassium chloride, magnesium chloride, carrageenan, potassium citrate, **C. cohnii oil, calcium carbonate, m-inositol, potassium hydroxide, ferrous sulphate, taurine, choline bitartrate, choline chloride, L-carnitine, dl-α-toco pheryl acetate, cytidine 5'-monophosphate, zinc sulphate, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate, adenosine 5'- monophosphate, calcium pantothenate, niacinamide, vitamin A palmitate, cupric sulphate, riboflavin, thiamine hydrochloride, pyridoxine hydrochloride, folic acid, phylloquinone, manganese sulphate, sodium selenite, biotin, vitamin D3, cyanocobalamin. May contain sodium chloride, potas sium phosphate. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, lactose, and other soy components. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC SPECIAL CARE 24 (WITH IRON) Hypercaloric, DHA- and ARA-enriched formula For preterm infants

38 SIMILAC SPECIAL CARE 24 HIGH PROTEIN (WITH IRON) Hypercaloric, DHA and ARA-enriched formula For preterm infants INDICATIONS FOR USE For infants who are born prematurely and have additional nutrient needs that were not met in-utero and who may need extra protein to help support growth. Recommended until infant reaches 3600 g (approximately 8 lb). For oral or tube feeding use. Safety precautions: Use under medical supervision. Not intended for feeding preterm infants after they reach a weight of 3600 g, or as directed by a physician. Do not exceed a protein intake of: g/kg/day for infants up to 1000 g ( g/100 Cal) g/kg/day for infants from g ( g/100 Cal) If signs of intolerance develop, slow feeding or discontinue. Not for parenteral use. FEATURES AND BENEFITS Specially formulated with extra vitamins, minerals, protein and calories to support the growth and development of preterm, very-low-birth-weight infants. Consistent with current expert recommendations for protein intake. 1,2 Increased caloric density; provides 81 Cal per 100 ml (24 Cal/30 ml). Approximately 10% more protein than Similac Special Care 24 (3.30 g per 100 Cal or 2.67 g/100 ml). - Studies have shown that the growth of hospitalized infants is related to protein intake. 3,4 - A convenient way to deliver additional protein in a preferred liquid form. 5 Calcium and phosphorus at concentrations and ratio (1.8:1) that support intrauterine accretion rates. 6 Approximately 2 mg iron/kg body weight per day when fed at 120 Cal/kg/day. Approximately 40% of fat as medium-chain triglycerides, an easily digested and well-absorbed fat source. 7 DHA (0.25% ), an Omega-3 fatty acid, and ARA (0.4% ), an Omega-6 fatty acid, to support the normal physical development of the brain and eyes. Unique blend of nucleotides (72 mg/l). No palm olein oil. Easy to digest. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 0.81 Protein (% of total energy) 13.2 Fat (% of total energy) 46.7 Carbohydrate (% of total energy) 40.1 Total Cal:g nitrogen ratio 193:1 Non-protein Cal:g nitrogen ratio 168:1 Water (g/l) 880 Osmolality (mosm/kg water) 296 Renal solute load (mosm/l) 225 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ N/A pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Similac Special Care mL 48/case High Protein (with iron) plastic bottles Of total fatty acids. Similar to other infant formulas. REFERENCES: 1. Klein CJ. J Nutr 2002;132:1395S-577S. 2. Cochrane Review (2010). Higher versus lower protein intake in formula-fed low birth weight infants. Premji SS, Fenton TR, Sauve RS. 3. Kashyap S, et al. Pediatr Res 1994;35(6): Kashyap S, et al. J Pediatr 1988;113: Health Canada. Accessed Mize et al. Am J Clin Nutr 1995;62: Duggan C, Watkins JB and Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton

39 ENERGY Per 100 ml Per 100 Cal Per 59 ml ENERGY (Cal [kj]) 81 (339) 100 (418) 48 (200) PROTEIN (g) % of total energy 13.2 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Dry skim milk, whey protein concentrate FAT (g) % of total energy 46.7 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 7.32:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) Medium chain triglycerides, soy oil, coconut oil, high oleic sunflower oil, ARA and DHA MCT oil (% of total fats) 39.5 CARBOHYDRATE (g) % of total energy 40.1 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Corn maltodextrin, lactose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 167 (556) 206 (686) 98 (328) Vitamin D3 (mcg [IU]) 3.05 (122) 3.77 (151) 1.80 (72) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 35 (1.52) 43 (1.88) 21 (0.90) Potassium (mg [mmol]) 118 (3.03) 146 (3.74) 70 (1.79) Chloride (mg [mmol]) 66 (1.86) 81 (2.30) 39 (1.10) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION INGREDIENTS Similac Special Care 24 High Protein (with iron), Ready to use: Water, corn maltodextrin, dry skim milk, whey protein concentrate, medium chain triglycerides ( modified coconut oil and/or palm kernel oil), lactose, soy oil, coconut oil, high oleic sunflower oil, calcium phosphate, sodium citrate, ascorbic acid, soy lecithin, monoglycerides, *M. alpina oil, carrageenan, potassium citrate, **C. cohnii oil, magnesium chloride, m-inositol, potassium chloride, potassium hydroxide, calcium carbonate, ferrous sulphate, taurine, choline bitartrate, choline chloride, L-carnitine, dl-α-tocopheryl acetate, cytidine 5'- monophosphate, zinc sulphate, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate, adenosine 5'-monophosphate, calcium pantothenate, niacinamide, vitamin A palmitate, cupric sulphate, riboflavin, thiamine hydrochloride, pyridoxine hydrochloride, folic acid, phyllo quinone, manganese sulphate, sodium selenite, biotin, vitamin D3, cyanocobalamin. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, lactose, other soy components. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC SPECIAL CARE 24 HIGH PROTEIN (WITH IRON) Hypercaloric, DHA and ARA-enriched formula For preterm infants

40 SIMILAC NEOSURE OMEGA-3 AND OMEGA-6 DHA- and ARA-enriched formula For preterm infants 0-12 months corrected age INDICATIONS FOR USE For preterm infants being discharged home and who continue to require additional intakes of specific nutrients and higher nutrient to energy ratios to achieve optimal growth and bone mineralization. For breastfed infants, supplementing with feedings of prepared post-discharge formula (as directed by the health care professional) is recommended as a strategy for meeting additional nutrient requirements. 1 The health care professional will determine when to switch to a term formula (such as Similac Advance Omega-3 and Omega-6) according to hospital guidelines. - The American Academy of Pediatrics recommends that the use of a postdischarge formula should be individualized to optimize the growth trajectory of the infant over the first year. 1 - Bhatia (2005) suggests stopping at 4-6 months corrected age if all growth parameters are >25th percentile. 2 For oral or tube feeding use. Safety precautions: Not for parenteral use. Use under medical supervision. FEATURES AND BENEFITS 74 Cal per 100 ml (22 Cal per 30 ml). Higher amounts of protein and select vitamins & minerals than term infant formulas to promote development and catch-up growth in preterm infants. - 33% more protein to help meet higher protein requirements. - Approximately 35% more calcium & phosphorus to support baby s growing bones. Peer-reviewed studies evaluating the use of preterm post-discharge formula compared to term infant formula in preterm infants have demonstrated: - Greater gains in weight, length, and head circumference compared to those fed term formula. 3 - An increase in lean body mass rather than fat mass. - More rapid and complete catch-up growth with an increase in lean body mass rather than fat mass. 4 - Increase in lean body mass with no significant increase in skinfold thickness. 5 DHA (0.25% ), an Omega-3 fatty acid, and ARA (0.4% ), an Omega-6 fatty acid, to support the normal physical development of the brain and eyes. Approximately 25% of fat as medium-chain triglycerides, an easily-digested and well-absorbed fat source. 6 Unique blend of nucleotides (72 mg/l). No palm olein oil. Easy to digest. TECHNICAL DATA Powder (at standard dilution) Caloric density (Cal/mL) Protein (% of total energy) 11 Fat (% of total energy) 49 Carbohydrate (% of total energy) 40 Total Cal:g nitrogen ratio 228:1 Non-protein Cal:g nitrogen ratio 203:1 Water (g/l) 890 Osmolality (mosm/kg water) 250 Renal solute load (mosm/l) Viscosity at room temperature/ - chilled Minimum tube size for gravity/ N/A pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Powder Similac Neosure 363-g cans 6/case Omega-3 and Omega-6 Similac Neosure Omega-3 and Omega-6 Powder Mixing Chart Caloric Density (Cal/30 ml) Unpacked, level scoops # Water (ml) Approximate Yield ## (ml) (standard) # Use only scoop provided in the can. ## Calculated using displacement volume and rounded to the nearest whole number. 40

41 ENERGY Per 100 ml Per 100 g Powder (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) 513 (2146) 74.4 (311) 100 (418) PROTEIN (g) % of total energy 11 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Skim milk, whey protein concentrate, whey protein hydrolysate FAT (g) % of total energy 49 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 8.24:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) Soy oil, high oleic safflower oil, MCT oil, coconut oil, ARA and DHA MCT oil (% of total fats) 24.9 CARBOHYDRATE (g) % of total energy 40 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Corn syrup solids, lactose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 710 (2367) 103 (343) 138 (461) Vitamin D3 (mcg [IU]) 9 (359) 1.3 (52) 1.8 (70) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) 173 (7.52) 25 (1.09) 34 (1.47) Potassium (mg [mmol]) 732 (18.77) 106 (2.72) 143 (3.66) Chloride (mg [mmol]) 386 (10.89) 56 (1.58) 75 (2.12) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) INGREDIENTS Similac Neosure Omega-3 and Omega-6, Powder: Skim milk, corn syrup solids, lactose, soy oil, high oleic safflower oil, medium chain triglycerides (modified coconut and/or palm kernel oils), whey protein concentrate, coconut oil, whey protein hydrolysate, calcium phosphate, ascorbic acid, M. alpina oil*, calcium carbonate, m-inositol, C. cohnii oil**, potassium citrate, magnesium chloride, potassium chloride, taurine, ferrous sulphate, choline bitartrate, choline chloride, L-carnitine, ascorbyl palmitate, cytidine 5'-monophosphate, d-α-tocopheryl acetate, disodium guanosine 5'-monophosphate, zinc sulphate, disodium uridine 5'-monophosphate, niacinamide, adenosine 5'-monophosphate, mixed tocopherols, calcium d-pantothenate, cupric sulphate, thiamine chloride hydrochloride, vitamin A palmitate, riboflavin, pyridoxine hydrochloride, β-carotene, folic acid, manganese sulphate, phylloquinone, biotin, sodium selenate, vitamin D3, cyanocobalamin. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, lactose, other soy components. NUTRITIONAL INFORMATION Compared to Similac Advance Omega-3 and Omega-6 (per 100 Cal). Similac Neosure formulation used in this study may differ slightly from current Similac Neosure Omega-3 and Omega-6 product. Compared to infants fed term formula or a combination of preterm post-discharge & term formula. Of total fatty acids. Similar to other infant formulas. REFERENCES: 1. American Academy of Pediatrics Committee on Nutrition. Nutritional Needs of the Preterm Infant In: Kleinman RE, Greer FR, eds. Pediatric Nutrition. 7th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2014: Bhatia J. J Perinatol 2005;25(suppl 2):S15-S Carver JD, Wu PYK, Hall RT, et al. Pediatrics 2001;107: Cooke RJ, Griffin IJ, and McCormick K. Pediatr Res 2010;67: Lucas A, Fewtrell MS, Morley R, et al. Pediatrics 2001;108: Duggan C, Watkins JB and Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC NEOSURE OMEGA-3 AND OMEGA-6 DHA- and ARA-enriched formula For preterm infants 0-12 months corrected age

42 SIMILAC NEOSURE OMEGA-3 AND OMEGA-6 DHA- and ARA-enriched formula For preterm infants 0-12 months corrected age INDICATIONS FOR USE For preterm infants who are being prepared for discharge home but continue to require additional intakes of specific nutrients and higher nutrient to energy ratios to achieve optimal growth and bone mineralization. For breastfed infants, supplementing with feedings of prepared post-discharge formula (as directed by the health care professional) is recommended as a strategy for meeting additional nutrient requirements. 1 The health care professional will determine when to switch to a term formula (such as Similac Advance Omega-3 and Omega-6) according to hospital guidelines. - The American Academy of Pediatrics recommends that the use of a post-discharge formula should be individualized to optimize the growth trajectory of the infant over the first year. 1 - Bhatia (2005) suggests stopping at 4-6 months corrected age if all growth parameters are >25th percentile. 2 For oral or tube feeding use. Safety precautions: Not for parenteral use. Use under medical supervision. FEATURES AND BENEFITS 74 Cal per 100 ml (22 Cal per 30 ml). Higher amounts of protein and select vitamins & minerals than term infant formulas to promote development and catch-up growth in preterm infants. - 33% more protein to help meet higher protein requirements. - Approximately 35% more calcium & phosphorus to support baby s growing bones. Peer-reviewed studies evaluating the use of preterm post-discharge formula compared to term infant formula in preterm infants have demonstrated: - Greater gains in weight, length, and head circumference compared to those fed term formula. 3 - An increase in lean body mass rather than fat mass. - More rapid and complete catch-up growth with an increase in lean body mass rather than fat mass. 4 - Increase in lean body mass with no significant increase in skinfold thickness. 5 DHA (0.15% ), an Omega-3 fatty acid, and ARA (0.4% ), an Omega-6 fatty acid, to support the normal physical development of the brain and eyes. Approximately 25% of fat as medium-chain triglycerides, an easilydigested and well-absorbed fat source. 6 Unique blend of nucleotides (72 mg/l). No palm olein oil. Easy to digest. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 0.74 Protein (% of total energy) 11.2 Fat (% of total energy) 48.4 Carbohydrate (% of total energy) 40.4 Total Cal:g nitrogen ratio 223:1 Non-protein Cal:g nitrogen ratio 198:1 Water (g/l) 890 Osmolality (mosm/kg water) 250 Renal solute load (mosm/l) Viscosity at room temperature/ - chilled Minimum tube size for gravity/ N/A pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Similac Neosure 59-mL plastic 48/case Omega-3 and Omega-6 bottles 42

43 ENERGY Per 100 ml Per 100 Cal Per 59 ml ENERGY (Cal [kj]) 74 (311) 100 (418) 44 (183) PROTEIN (g) % of total energy 11.2 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Skim milk, whey protein concentrate FAT (g) % of total energy 48.4 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 6.5:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) Soy oil, coconut oil, MCT oil, ARA and DHA MCT oil (% of total fats) 24.4 CARBOHYDRATE (g) % of total energy 40.4 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Corn syrup solids, lactose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 103 (342) 138 (460) 61 (202) Vitamin D3 (mcg [IU]) 1.3 (52) 1.8 (70) 0.77 (31) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) 25 (1.09) 33 (1.43) 15 (0.64) Potassium (mg [mmol]) 106 (2.72) 142 (3.64) 63 (1.60) Chloride (mg [mmol]) 56 (1.58) 75 (2.12) 33 (0.93) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION INGREDIENTS Similac Neosure Omega-3 and Omega-6, Ready to use: Water, skim milk, corn syrup solids, soy oil, lactose, coconut oil, whey protein concentrate, medium chain triglycerides (modified coconut and/or palm kernel oils), potassium citrate, ascorbic acid, monoglycerides, soy lecithin, calcium carbonate, M. alpina oil*, calcium phosphate tribasic, m-inositol, magnesium chloride, potassium hydroxide, C. cohnii oil**, carrageenan, taurine, choline chloride, ferrous sulphate, potassium chloride, choline bitartrate, L-carnitine, d-α-tocopheryl acetate, cytidine 5'-monophosphate, zinc sulphate, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate, niacinamide, adenosine 5'-monophosphate, calcium d-pantothenate, cupric sulphate, vitamin A palmitate, thiamine chloride hydrochloride, riboflavin, pyridoxine hydrochloride, β-carotene, folic acid, manganese sulphate, phylloquinone, biotin, sodium selenate, vitamin D3, cyanocobalamin. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, lactose, other soy components. Compared to Similac Advance Omega-3 and Omega-6 (per 100 Cal). Similac Neosure used up to 12 months corrected age. Formulation used in this study may differ slightly from current Similac Neosure Omega-3 and Omega-6 product. Compared to infants fed term formula or a combination of preterm post-discharge and term formula. Of total fatty acids. Similar to other infant formulas. REFERENCES: 1. American Academy of Pediatrics Committee on Nutrition. Nutritional Needs of the Preterm Infant In: Kleinman RE, Greer FR, eds. Pediatric Nutrition. 7th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2014: Bhatia J. J Perinatol 2005;25(suppl 2):S15-S Carver JD, Wu PYK, Hall RT, et al. Pediatrics 2001;107: Cooke RJ, Griffin IJ, and McCormick K. Pediatr Res 2010;67: Lucas A, Fewtrell MS, Morley R, et al. Pediatrics 2001;108: Duggan C, Watkins JB and Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC NEOSURE OMEGA-3 AND OMEGA-6 DHA- and ARA-enriched formula For preterm infants 0-12 months corrected age

44 NOTES:

45 TERM INFANTS Term Infants IN THIS SECTION Similac Advance Omega-3 and Omega-6 (Non-GMO) Similac Advance Omega-3 and Omega-6 (Non-GMO) (HFS) Similac Advance Omega-3 and Omega-6 Similac Go & Grow Omega-3 and Omega-6 (Non-GMO) Similac Go & Grow Omega-3 and Omega-6 Similac Go & Grow Similac Iron-Fortified Similac Lower Iron Similac Partially Broken Down Protein Similac Sensitive for babies sensitive to lactose Similac Sensitive for babies sensitive to lactose (HFS) Continued on next page

46 TERM INFANTS Term Infants IN THIS SECTION (continued) Similac Isomil with Omega-3 and Omega-6 Similac Isomil Omega-3 and Omega-6 (HFS) Similac Isomil Similac Isomil (Step 2) Similac 24 with Iron (HFS) Similac Alimentum Omega-3 and Omega-6 Similac Alimentum Similac Alimentum Omega-3 and Omega-6 (HFS) Step 2 products can be initiated from 6 months of age.

47 BREAST MILK - INSPIRING OUR RESEARCH AND INNOVATION Breast milk is the first and best way parents can promote their newborn's health and development. For those who are unable to breastfeed or who decide not to, Health Canada recommends commercial infant formula as the only alternative. 1 At Abbott Nutrition, breast milk inspires all our research and innovation when it comes to infant nutritional products. The addition of galactooligosaccharides, lutein and long-chain polyunsaturated fatty acids (DHA and ARA) to Similac Advance Omega-3 and Omega-6, our closest formula to breast milk, is a perfect example of formula innovation driven by our growing understanding of human milk. GALACTOOLIGOSACCHARIDES (GOS) Galactooligosaccharides are a type of oligosaccharide. Human milk oligosaccharides: Are the third largest component of breast milk; 2 May have a bifidogenic effect; 3 May be considered as the soluble fibre of human milk; 3,4 May contribute to the softer stools produced by breastfed babies. 5,6 LUTEIN Lutein is a carotenoid and antioxidant that may be transferred from mothers to babies during pregnancy and lactation. 7 Lutein has been found in the fetal eye and the umbilical cord. 7 Lutein is highly concentrated in colostrum and continues to be supplied to baby through breast milk. 7 DHA and ARA DHA and ARA are naturally found in breast milk and support the normal physical development of the brain and eyes. We are dedicated to making Similac products a trusted choice for babies who are nourished with infant formula. Our full line of products is designed to help meet a variety of nutritional needs, because every baby is unique. Amounts vary according to mother's diet. REFERENCES: 1. Health Canada Advisory Statement: Health Canada Raises Concerns Over Homemade Infant Formula. Accessed on Boehm G, Stahl B. J Nutr 137:847S 849S, Niittynen L, Kajander K, Korpela R. Scand J Food Nutr 2007;51(2): Engfer MB, Stahl B, Finke B, et al. Am J Clin Nutr 2000;71: Bongers MEJ, de Lorijn F, Reitsma JB, et al. Nutrition Journal 2007;6:8. 6. Scholtens PAMJ, Goossens DAM, Staiano A. World J Gastroenterol 2014;20(37): Hammond BR. Functional Food Reviews. 2012;4(3):

48 SIMILAC ADVANCE OMEGA-3 AND OMEGA-6 (NON-GMO) Step 1 DHA- and ARA-enriched formula For term infants 0+ months of age The only formula containing galactooligosaccharides and lutein INDICATIONS FOR USE For infants whose parents prefer to use products containing ingredients that are not genetically modified. For initial or supplemental feeding of term infants. For oral or tube feeding use. Safety precaution: Not for parenteral use. FEATURES AND BENEFITS Galactooligosaccharides (GOS) (4 g per litre of formula). Supplementing infant formula with galactooligosaccharides: - May help promote the growth of good bacteria in baby s intestinal tract. 1,2 - Helps promote softer stools, similar to breastfed babies. 3 Lutein (an antioxidant naturally found in breast milk): - May protect against oxidative damage in the eye. 4-7 DHA (0.20% ), an Omega-3 fatty acid, and ARA (0.4% ), an Omega-6 fatty acid, to support the normal physical development of the brain and eyes. 8 Unique blend of nucleotides (72 mg/l). No palm olein oil. Easy to digest. TECHNICAL DATA Powder (at standard dilution) Caloric density (Cal/mL) 0.68 Protein (% of total energy) 8.3 Fat (% of total energy) 49.9 Carbohydrate (% of total energy) 41.8 Total Cal:g nitrogen ratio 309:1 Non-protein Cal:g nitrogen ratio 284:1 Water (g/l) 901 Osmolality (mosm/kg water) 303 Renal solute load (mosm/l) 97 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ N/A pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Powder B Similac Advance 658-g container 6/case Omega-3 and Omega-6 (Non-GMO) Excluding inherent sources. Of total fatty acids. Similar to other infant formulas. REFERENCES: 1. Ben XM et al. Supplementation of milk formula with galacto-oligosaccharides improves intestinal micro-flora and fermentation in term infants. Chin Med J (Engl) 2004;117: Ben XM et al. Low level of galacto-oligosaccharide in infant formula stimulates growth of intestinal Bifidobacteria and Lactobacilli. World J Gastroenterol 2008;14(42): Williams T et al. Tolerance of Infant Formulas Containing Prebiotics in Healthy, Term Infants. JPGN 2014;59(5): Krinsky NI et al. Biologic Mechanisms of the Protective Role of Lutein and Zeaxanthin in the Eye. Ann Rev Nutr 2003;23: Hammond BR. Possible role for dietary lutein and zeaxanthin in visual development. Nutr Rev 2008;66(12): Zimmer JP et al. Possible influences of lutein and zeaxanthin on the developing retina. Clin Ophtalmol 2007;1: Perrone SP et al. Effects of Lutein on Oxidative Stress in the Term Newborn: A Pilot Study. Neonatology 2010;97: Canadian Food Inspection Agency: Guide to Food Labelling and Advertising, Chapter 8. Available at inspection.gc.ca/food/labelling/food-labelling-for-industry/health-claims/eng/ / ? chap=8#s16c8. Accessed August

49 ENERGY Per 100 ml Per 100 g Powder (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) 509 (2130) 68 (283) 100 (418) PROTEIN (g) % of total energy 8.3 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Dry skim milk, whey protein concentrate, whey protein hydrolysate FAT (g) % of total energy 49.9 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 9.71:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic safflower or sunflower oil, soy oil, coconut oil, ARA and DHA MCT oil (% of total fats) CARBOHYDRATE (g) % of total energy 41.8 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Lactose, dry skim milk, galactooligosaccharides Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 430 (1433) 57 (191) 85 (282) Vitamin D3 (mcg [IU]) 7.63 (305) 1.02 (40.5) 1.50 (59.9) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 135 (5.87) 18 (0.78) 27 (1.15) Potassium (mg [mmol]) 600 (15.38) 80 (2.06) 118 (3.02) Chloride (mg [mmol]) 333 (9.39) 44 (1.25) 65 (1.85) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION GOS is approximately 1% of the total energy and provides approximately 1.3 Cal/g. INGREDIENTS Similac Advance Omega-3 and Omega-6 (Non-GMO), Powder: Lactose, dry skim milk, high oleic safflower or sunflower oil, soy oil, coconut oil, galactooligosaccharides (GOS), whey protein concentrate, whey protein hydrolysate, potassium citrate, calcium carbonate, *M. alpina oil, tricalcium phosphate, potassium hydroxide, **C. cohnii oil, soy lecithin, magnesium chloride, sodium chloride, choline bitartrate, ascorbic acid, L-tryptophan, ferrous sulphate, taurine, m-inositol, cytidine 5'-monophosphate, disodium guanosine 5'-monophosphate, ascorbyl palmitate, disodium uridine 5'-monophosphate, zinc sulphate, d-α-tocopheryl acetate, adenosine 5'-monophosphate, L-carnitine, mixed tocopherols, niacinamide, calcium d-pantothenate, cupric sulphate, vitamin A palmitate, thiamine hydrochloride, pyridoxine hydrochloride, riboflavin, lutein, folic acid, manganese sulphate, β-carotene, phylloquinone, biotin, sodium selenate, potassium iodide, vitamin D3, cyanocobalamin. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Lactose, other soy components, coconut oil. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC ADVANCE OMEGA-3 AND OMEGA-6 (NON-GMO) Step 1 DHA- and ARA-enriched formula For term infants 0+ months of age

50 SIMILAC ADVANCE OMEGA-3 AND OMEGA-6 (NON-GMO) Step 1 DHA- and ARA-enriched formula For term infants 0+ months of age The only formula containing galactooligosaccharides and lutein INDICATIONS FOR USE For infants whose parents prefer to use products containing ingredients that are not genetically modified. For initial or supplemental feeding of term infants. For oral or tube feeding use. Safety precaution: Not for parenteral use. FEATURES AND BENEFITS Galactooligosaccharides (GOS) (4 g per litre of formula). Supplementing infant formula with galactooligosaccharides: - May help promote the growth of good bacteria in baby s intestinal tract. 1,2 - Helps promote softer stools, similar to breastfed babies. 3 Lutein (an antioxidant naturally found in breast milk): - May protect against oxidative damage in the eye. 4-7 DHA (0.20% ), an Omega-3 fatty acid, and ARA (0.4% ), an Omega-6 fatty acid, to support the normal physical development of the brain and eyes. 8 Unique blend of nucleotides (72 mg/l). No palm olein oil. Easy to digest. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 0.68 Protein (% of total energy) 8.3 Fat (% of total energy) 49.3 Carbohydrate (% of total energy) 42.4 Total Cal:g nitrogen ratio 304:1 Non-protein Cal:g nitrogen ratio 277:1 Water (g/l) 900 Osmolality (mosm/kg water) 306 Renal solute load (mosm/l) 127 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ N/A pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Similac Advance 8 x 59-mL plastic 6/case Omega-3 and Omega-6 bottles (Non-GMO) Excluding inherent sources. Of total fatty acids. Similar to other infant formulas. REFERENCES: 1. Ben XM et al. Supplementation of milk formula with galacto-oligosaccharides improves intestinal micro-flora and fermentation in term infants. Chin Med J (Engl) 2004;117: Ben XM et al. Low level of galacto-oligosaccharide in infant formula stimulates growth of intestinal Bifidobacteria and Lactobacilli. World J Gastroenterol 2008;14(42): Williams T et al. Tolerance of Infant Formulas Containing Prebiotics in Healthy, Term Infants. JPGN 2014;59(5): Krinsky NI et al. Biologic Mechanisms of the Protective Role of Lutein and Zeaxanthin in the Eye. Ann Rev Nutr 2003;23: Hammond BR. Possible role for dietary lutein and zeaxanthin in visual development. Nutr Rev 2008;66(12): Zimmer JP et al. Possible influences of lutein and zeaxanthin on the developing retina. Clin Ophtalmol 2007;1: Perrone SP et al. Effects of Lutein on Oxidative Stress in the Term Newborn: A Pilot Study. Neonatology 2010;97: Canadian Food Inspection Agency: Guide to Food Labelling and Advertising, Chapter 8. Available at food/labelling/food-labelling-for-industry/health-claims/eng/ / ?chap=8#s16c8. Accessed August

51 ENERGY Per 100 ml Per 100 Cal Per 59 ml ENERGY (Cal [kj]) 67.6 (283) 100 (418) 40 (167) PROTEIN (g) % of total energy 8.3 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Dry skim milk, whey protein concentrate FAT (g) % of total energy 49.3 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 10.0:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic safflower oil, soy oil, coconut oil, ARA and DHA MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) % of total energy 42.4 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Lactose, galactooligosaccharides Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 61 (203) 90 (300) 36 (120) Vitamin D3 (mcg [IU]) 0.9 (35) 1.3 (52) 0.5 (21) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 18 (0.78) 27 (1.16) 11 (0.46) Potassium (mg [mmol]) 79 (2.03) 117 (3.00) 47 (1.20) Chloride (mg [mmol]) 40 (1.13) 59 (1.67) 24 (0.67) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION GOS is approximately 1% of the total energy and provides approximately 1.3 Cal/g. INGREDIENTS Similac Advance Omega-3 and Omega-6 (Non-GMO), Ready to use: Water, lactose, dry skim milk, high oleic safflower oil, soy oil, galactooligosaccharides (GOS), coconut oil, whey protein concentrate, potassium citrate, calcium carbonate, ascorbic acid, *M. alpina oil, monoglycerides, soy lecithin, **C. cohnii oil, sodium citrate, carrageenan, potassium chloride, sodium chloride, potassium phosphate dibasic, magnesium chloride, ferrous sulphate, choline bitartrate, potassium hydroxide, choline chloride, taurine, m-inositol, cytidine 5 -monophosphate, d-α-tocopheryl acetate, L-tryptophan, zinc sulphate, disodium guanosine 5 -monophosphate, disodium uridine 5 -monophosphate, adenosine 5 -monophosphate, niacinamide, L-carnitine, calcium d-pantothenate, cupric sulphate, vitamin A palmitate, thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, folic acid, lutein, manganese sulphate, phylloquinone, β-carotene, biotin, vitamin D3, cyanocobalamin. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Lactose, other soy components, coconut oil, citric acid. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC ADVANCE OMEGA-3 AND OMEGA-6 (NON-GMO) Step 1 DHA- and ARA-enriched formula For term infants 0+ months of age

52 SIMILAC ADVANCE OMEGA-3 AND OMEGA-6 Step 1 DHA- and ARA-enriched formula For term infants 0+ months of age The only formula containing galactooligosaccharides and lutein INDICATIONS FOR USE For initial or supplemental feeding of term infants. For oral or tube feeding use. Safety precaution: Not for parenteral use. FEATURES AND BENEFITS Galactooligosaccharides (GOS) (4 g per litre of formula). Supplementing infant formula with galactooligosaccharides: - May help promote the growth of good bacteria in baby s intestinal tract. 1,2 - Helps promote softer stools, similar to breastfed babies. 3 Lutein (an antioxidant naturally found in breast milk): - May protect against oxidative damage in the eye. 4-7 DHA (0.20% ), an Omega-3 fatty acid, and ARA (0.4% ), an Omega-6 fatty acid, to support the normal physical development of the brain and eyes. 8 Unique blend of nucleotides (72 mg/l). No palm olein oil. Easy to digest. TECHNICAL DATA Concentrated Ready to use Liquid (at standard dilution) Powder (at standard dilution) Caloric density (Cal/mL) Protein (% of total energy) Fat (% of total energy) Carbohydrate (% of total energy) Total Cal:g nitrogen ratio 304:1 309:1 309:1 Non-protein Cal:g nitrogen ratio 277:1 289:1 284:1 Water (g/l) Osmolality (mosm/kg water) Renal solute load (mosm/l) Viscosity at room temperature/ chilled Minimum tube size for gravity/ pump feeding (Fr) N/A N/A N/A Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Similac Advance 235-mL cans 12/case Omega-3 and Omega Similac Advance 235-mL cans 4 x 6/case Omega-3 and Omega Similac Advance 945-mL reclosable 6/case Omega-3 and Omega-6 plastic bottles Concentrated Liquid Similac Advance 385-mL cans 12/case Omega-3 and Omega-6 Powder Similac Advance 227-g cans 6/case Omega-3 and Omega B Similac Advance 658-g containers 6/case Omega-3 and Omega-6 Excluding inherent sources. Of total fatty acids. Similar to other infant formulas. REFERENCES: 1. Ben XM et al. Supplementation of milk formula with galacto-oligosaccharides improves intestinal micro-flora and fermentation in term infants. Chin Med J (Engl) 2004;117: Ben XM et al. Low level of galacto-oligosaccharide in infant formula stimulates growth of intestinal Bifidobacteria and Lactobacilli. World J Gastroenterol 2008; 14(42): Williams T et al. Tolerance of Infant Formulas Containing Prebiotics in Healthy, Term Infants. JPGN 2014;59(5): Krinsky NI et al. Biologic Mechanisms of the Protective Role of Lutein and Zeaxanthin in the Eye. Ann Rev Nutr 2003;23: Hammond BR. Possible role for dietary lutein and zeaxanthin in visual development. Nutr Rev 2008; 66(12): Zimmer JP et al. Possible influences of lutein and zeaxanthin on the developing retina. Clin Ophtalmol 2007;1: Perrone SP et al. Effects of Lutein on Oxidative Stress in the Term Newborn: A Pilot Study. Neonatology 2010;97: Canadian Food Inspection Agency: Guide to Food Labelling and Advertising, Chapter 8. Available at inspection.gc.ca/food/labelling/food-labelling-for-industry/health-claims/eng/ / ? chap=8#s16c8. Accessed August

53 ENERGY Per 100 ml Per 100 g Powder (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) 509 (2130) 68 (283) 100 (418) PROTEIN (g) % of total energy 8.3 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Skim milk, whey protein concentrate, whey protein hydrolysate FAT (g) % of total energy 49.9 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 9.71:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic sunflower oil, soy oil, coconut oil, ARA and DHA MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) % of total energy 41.8 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Lactose, galactooligosaccharides Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 430 (1433) 57 (190) 83 (278) Vitamin D3 (mcg [IU]) 7.63 (305) 1.01 (40.5) 1.49 (60) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 135 (5.87) 18 (0.78) 27 (1.15) Potassium (mg [mmol]) 600 (15.38) 80 (2.05) 118 (3.02) Chloride (mg [mmol]) 333 (9.39) 44 (1.24) 65 (1.83) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) Nutritional information for Similac Advance Omega-3 and Omega-6, Powder GOS is approximately 1% of the total energy and provides approximately 1.3 Cal/g. INGREDIENTS Similac Advance Omega-3 and Omega-6, Powder: Lactose, dry skim milk, high oleic safflower or sunflower oil, soy oil, coconut oil, galactooligosaccharides (GOS), whey protein concentrate, whey protein hydrolysate, potassium citrate, calcium carbonate, *M. alpina oil, tricalcium phosphate, potassium hydroxide, **C. cohnii oil, magnesium chloride, sodium chloride, choline bitartrate, ascorbic acid, soy lecithin, L-tryptophan, ferrous sulphate, taurine, m-inositol, cytidine 5'-monophosphate, disodium guanosine 5'-monophosphate, ascorbyl palmitate, disodium uridine 5'-monophosphate, zinc sulphate, d-α-tocopheryl acetate, adenosine 5'-monophosphate, L-carnitine, mixed tocopherols, niacinamide, calcium d-pantothenate, cupric sulphate, vitamin A palmitate, thiamine hydrochloride, pyridoxine hydrochloride, riboflavin, lutein, folic acid, manganese sulphate, β-carotene, phylloquinone, biotin, sodium selenate, potassium iodide, vitamin D3, cyanocobalamin. Similac Advance Omega-3 and Omega-6, Concentrated Liquid: Water, lactose, evaporated or dry skim milk, high oleic vegetable oil (safflower or sunflower), coconut oil, soy oil, galactooligosaccharides (GOS), whey protein concentrate, potassium citrate, calcium carbonate, monoglycerides, soy lecithin, *M. alpina oil, potassium chloride, **C. cohnii oil, choline bitartrate, ascorbic acid, L-tryptophan, carrageenan, magnesium chloride, taurine, ferrous sulphate, m-inositol, cytidine 5'-monophosphate, citric acid, d-α-tocopheryl acetate, disodium guanosine 5'-monophosphate, zinc sulphate, disodium uridine 5'-monophosphate, adenosine 5'-monophosphate, niacinamide, L-carnitine, calcium pantothenate, cupric sulphate, vitamin A palmitate, thiamine chloride hydrochloride, riboflavin, pyridoxine hydrochloride, folic acid, manganese sulphate, phylloquinone, lutein, biotin, β-carotene, sodium selenate, vitamin D3, cyanocobalamin. Similac Advance Omega-3 and Omega-6, Ready to use: Water, lactose, dry skim milk, high oleic safflower oil, soy oil, galactooligosaccharides (GOS), coconut oil, whey protein concentrate, ascorbic acid, potassium citrate, calcium carbonate, *M. alpina oil, monoglycerides, soy lecithin, **C. cohnii oil, sodium citrate, carrageenan, potassium chloride, sodium chloride, potassium phosphate, magnesium chloride, ferrous sulphate, choline bitartrate, choline chloride, taurine, m-inositol, cytidine 5'-monophosphate, d-α-tocopheryl acetate, L-tryptophan, zinc sulphate, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate, adenosine 5'-monophosphate, niacinamide, L-carnitine, calcium d-pantothenate, cupric sulphate, vitamin A palmitate, thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, folic acid, lutein, manganese sulphate, phylloquinone, β-carotene, biotin, vitamin D3, cyanocobalamin. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Coconut oil, lactose, other soy components. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). NUTRITIONAL INFORMATION Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC ADVANCE OMEGA-3 AND OMEGA-6 Step 1 DHA- and ARA-enriched formula For term infants 0+ months of age

54 SIMILAC GO & GROW OMEGA-3 AND OMEGA-6 (NON-GMO) Step 2 DHA- and ARA-enriched formula For infants and toddlers 6 to 24 months of age The only Step 2 formula containing galactooligosaccharides and lutein INDICATIONS FOR USE Transition formula for healthy, term infants who are 6 months or older and whose parents prefer to use products containing ingredients that are not genetically modified. For initial or supplemental feeding of terms infants. For oral or tube feeding use. Safety precaution: Not for parenteral use. FEATURES AND BENEFITS Specially formulated to help bridge the nutritional intake gaps that can be associated with the transition to table foods. Calcium enriched (50% more calcium than Similac Advance Omega-3 and Omega-6 Non-GMO) to support growing infants. Galactooligosaccharides (GOS) (4 g per litre of formula). Supplementing infant formula with galactooligosaccharides: - May help promote the growth of good bacteria in baby s intestinal tract. 1,2 - Helps promote softer stools, similar to breastfed babies. 3 Lutein (an antioxidant naturally found in breast milk): - May protect against oxidative damage in the eye. 4-7 DHA (0.20% ), an Omega-3 fatty acid, and ARA (0.4% ), an Omega-6 fatty acid, to support the normal physical development of the brain and eyes. 8 Unique blend of nucleotides (72 mg/l). No palm olein oil. Easy to digest. TECHNICAL DATA Powder (at standard dilution) Caloric density (Cal/mL) 0.68 Protein (% of total energy) 8.3 Fat (% of total energy) 49.9 Carbohydrate (% of total energy) 41.8 Total Cal:g nitrogen ratio 309:1 Non-protein Cal:g nitrogen ratio 284:1 Water (g/l) 901 Osmolality (mosm/kg water) 303 Renal solute load (mosm/l) 97.0 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ N/A pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Powder B Similac Go & Grow 658-g containers 6/case Omega-3 and Omega-6 (Non-GMO) Excluding inherent sources. Of total fatty acids. Similar to other infant formulas. REFERENCES: 1. Ben XM et al. Supplementation of milk formula with galacto-oligosaccharides improves intestinal micro-flora and fermentation in term infants. Chin Med J (Engl) 2004;117: Ben XM et al. Low level of galacto-oligosaccharide in infant formula stimulates growth of intestinal Bifidobacteria and Lactobacilli. World J Gastroenterol 2008;14(42): Williams T et al. Tolerance of Infant Formulas Containing Prebiotics in Healthy, Term Infants. JPGN 2014;59(5): Krinsky NI et al. Biologic Mechanisms of the Protective Role of Lutein and Zeaxanthin in the Eye. Ann Rev Nutr 2003;23: Hammond BR. Possible role for dietary lutein and zeaxanthin in visual development. Nutr Rev 2008; 66(12): Zimmer JP et al. Possible influences of lutein and zeaxanthin on the developing retina. Clin Ophtalmol 2007;1: Perrone SP et al. Effects of Lutein on Oxidative Stress in the Term Newborn: A Pilot Study. Neonatology 2010;97: Canadian Food Inspection Agency: Guide to Food Labelling and Advertising, Chapter 8. Available at Accessed August

55 ENERGY Per 100 ml Per 100 g Powder (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) 509 (2130) 68 (283) 100 (418) PROTEIN (g) % of total energy 8.3 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Dry skim milk, whey protein concentrate, whey protein hydrolysate FAT (g) % of total energy 49.9 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 9.71:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic safflower or sunflower oil, soy oil, coconut oil, ARA and DHA MCT oil (% of total fats) CARBOHYDRATE (g) % of total energy 41.8 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Lactose, dry skim milk, galactooligosaccharides Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 430 (1433) 57 (190) 85 (282) Vitamin D3 (mcg [IU]) 7.63 (305) 1.02 (40.5) 1.50 (60) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 135 (5.87) 18 (0.78) 27 (1.15) Potassium (mg [mmol]) 600 (15.38) 79 (2.06) 118 (3.02) Chloride (mg [mmol]) 333 (9.39) 44 (1.25) 65 (1.83) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) GOS is approximately 1% of the total energy and provides approximately 1.3 Cal/g. INGREDIENTS Similac Go & Grow Omega-3 and Omega-6 (Non-GMO), Powder: Lactose, dry skim milk, high oleic safflower or sunflower oil, soy oil, coconut oil, galactooligosaccharides (GOS), whey protein concentrate, tricalcium phosphate, whey protein hydrolysate, potassium citrate, *M. alpina oil, calcium carbonate, potassium hydroxide, **C. cohnii oil, soy lecithin, magnesium chloride, sodium chloride, choline bitartrate, ascorbic acid, L-tryptophan, ferrous sulphate, taurine, m-inositol, cytidine 5'-monophosphate, disodium guanosine 5'-monophosphate, ascorbyl palmitate, disodium uridine 5'-monophosphate, zinc sulphate, d-α-tocopheryl acetate, adenosine 5'-monophosphate, L-carnitine, mixed tocopherols, niacinamide, calcium d-pantothenate, cupric sulphate, vitamin A palmitate, thiamine hydrochloride, pyridoxine hydrochloride, riboflavin, lutein, folic acid, manganese sulphate, β-carotene, phylloquinone, biotin, sodium selenate, potassium iodide, vitamin D3, cyanocobalamin. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Lactose, other soy components, coconut oil. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). NUTRITIONAL INFORMATION Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC GO & GROW OMEGA-3 AND OMEGA-6 (NON-GMO) Step 2 DHA- and ARA-enriched formula For infants and toddlers 6 to 24 months of age

56 SIMILAC GO & GROW OMEGA-3 AND OMEGA-6 Step 2 DHA- and ARA-enriched formula For infants and toddlers 6 to 24 months of age The only Step 2 formula containing galactooligosaccharides and lutein INDICATIONS FOR USE Transition formula for healthy, term infants who are 6 months or older. For oral or tube feeding use. Safety precaution: Not for parenteral use. FEATURES AND BENEFITS Specially formulated to help bridge the nutritional intake gaps that can be associated with the transition to table foods. Calcium enriched (50% more calcium than Similac Advance Omega-3 and Omega-6) to support growing infants. Galactooligosaccharides (GOS) (4 g per litre of formula). Supplementing infant formula with galactooligosaccharides: - May help promote the growth of good bacteria in baby s intestinal tract. 1,2 - Helps promote softer stools, similar to breastfed babies. 3 Lutein (an antioxidant naturally found in breast milk): - May protect against oxidative damage in the eye. 4-7 DHA (0.20% ), an Omega-3 fatty acid, and ARA (0.4% ), an Omega-6 fatty acid, to support the normal physical development of the brain and eyes. 8 Unique blend of nucleotides (72 mg/l). No palm olein oil. Easy to digest. TECHNICAL DATA Concentrated Liquid (at standard dilution) Powder (at standard dilution) Caloric density (Cal/mL) Protein (% of total energy) Fat (% of total energy) Carbohydrate (% of total energy) Total Cal:g nitrogen ratio 309.2:1 309:1 Non-protein Cal:g nitrogen ratio 283.8:1 284:1 Water (g/l) Osmolality (mosm/kg water) Renal solute load (mosm/l) Viscosity at room temperature/ - - chilled Minimum tube size for gravity/ pump feeding (Fr) N/A N/A Low residue Gluten-free Kosher Halal AVAILABILITY Concentrated Liquid Similac Go & Grow 385-mL cans 12/case Omega-3 and Omega-6 Powder B Similac Go & Grow 658-g containers 6/case Omega-3 and Omega-6 Excluding inherent sources. Of total fatty acids. Similar to other infant formulas. REFERENCES: 1. Ben XM et al. Supplementation of milk formula with galacto-oligosaccharides improves intestinal micro-flora and fermentation in term infants. Chin Med J (Engl) 2004;117: Ben XM et al. Low level of galacto-oligosaccharide in infant formula stimulates growth of intestinal Bifidobacteria and Lactobacilli. World J Gastroenterol 2008;14(42): Williams T et al. Tolerance of Infant Formulas Containing Prebiotics in Healthy, Term Infants. JPGN 2014;59(5): Krinsky NI et al. Biologic Mechanisms of the Protective Role of Lutein and Zeaxanthin in the Eye. Ann Rev Nutr 2003;23: Hammond BR. Possible role for dietary lutein and zeaxanthin in visual development. Nutr Rev 2008; 66(12): Zimmer JP et al. Possible influences of lutein and zeaxanthin on the developing retina. Clin Ophtalmol 2007;1: Perrone SP et al. Effects of Lutein on Oxidative Stress in the Term Newborn: A Pilot Study. Neonatology 2010;97: Canadian Food Inspection Agency: Guide to Food Labelling and Advertising, Chapter 8. Available at health-claims/eng/ / ?chap=8#s16c8. Accessed August

57 ENERGY Per 100 ml Per 100 g Powder (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) 509 (2130) 68 (283) 100 (418) PROTEIN (g) % of total energy 8.3 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Skim milk, whey protein concentrate, whey protein hydrolysate FAT (g) % of total energy 49.9 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 9.71:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic sunflower oil, soy oil, coconut oil, ARA and DHA MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) % of total energy 41.8 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Lactose, galactooligosaccharides Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 430 (1433) 57 (190) 83 (278) Vitamin D3 (mcg [IU]) 7.63 (305) 1.01 (40.5) 1.49 (60) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 135 (5.87) 18 (0.78) 27 (1.15) Potassium (mg [mmol]) 600 (15.38) 79 (2.03) 95 (2.43) Chloride (mg [mmol]) 333 (9.39) 44 (1.24) 65 (1.83) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) Nutritional information for Similac Go & Grow, Powder GOS is approximately 1% of the total energy and provides approximately 1.3 Cal/g. INGREDIENTS Similac Go & Grow Omega-3 and Omega-6, Powder: Lactose, dry skim milk, high oleic safflower oil or high oleic sunflower oil, soy oil, coconut oil, galactooligosaccharides (GOS), whey protein concentrate, tricalcium phosphate, whey protein hydrolysate, potassium citrate, *M. alpina oil, calcium carbonate, potassium hydroxide, **C. cohnii oil, magnesium chloride, sodium chloride, choline bitartrate, ascorbic acid, soy lecithin, L-tryptophan, ferrous sulphate, taurine, m-inositol, cytidine 5'-monophosphate, disodium guanosine 5'-monophosphate, ascorbyl palmitate, disodium uridine 5'-monophosphate, zinc sulphate, d-α-tocopheryl acetate, adenosine 5'-monophosphate, L-carnitine, mixed tocopherols, niacinamide, calcium d-pantothenate, cupric sulphate, vitamin A palmitate, thiamine hydrochloride, pyridoxine hydrochloride, riboflavin, lutein, folic acid, manganese sulphate, β-carotene, phylloquinone, biotin, sodium selenate, potassium iodide, vitamin D3, cyanocobalamin. Similac Go & Grow Omega-3 and Omega-6, Concentrated Liquid: Water, lactose, evaporated or dry skim milk, high oleic vegetable oil (safflower or sunflower), coconut oil, soy oil, galactooligosaccharides (GOS), whey protein concentrate, calcium phosphate, potassium citrate, calcium carbonate, monoglycerides, soy lecithin, *M. alpina oil, potassium chloride, **C. cohnii oil, choline bitartrate, ascorbic acid, L-tryptophan, carrageenan, magnesium chloride, taurine, ferrous sulphate, cytidine 5'-monophosphate, citric acid, d-α-tocopheryl acetate, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate, adenosine 5'-monophosphate, niacinamide, L-carnitine, zinc sulphate, calcium pantothenate, vitamin A palmitate, thiamine chloride hydrochloride, cupric sulphate, riboflavin, pyridoxine hydrochloride, folic acid, phylloquinone, lutein, β-carotene, biotin, manganese sulphate, sodium selenate, vitamin D3, cyanocobalamin. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Coconut oil, lactose, other soy components. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). NUTRITIONAL INFORMATION Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC GO & GROW OMEGA-3 AND OMEGA-6 Step 2 DHA- and ARA-enriched formula For infants and toddlers 6 to 24 months of age

58 SIMILAC GO & GROW Step 2 formula For infants and toddlers 6 to 24 months of age INDICATIONS FOR USE For use in infants 6 months and older as they transition to solid foods. For oral or tube feeding use. Safety precaution: Not for parenteral use. FEATURES AND BENEFITS Specially formulated to help bridge the nutritional gaps that can be associated with the transition to table foods. Calcium enriched (~50% more calcium than Similac Iron-Fortified) to support growing bones. Unique blend of nucleotides (72 mg/l). No palm olein oil. Easy to digest. TECHNICAL DATA Concentrated Liquid (at standard dilution) Powder (at standard dilution) Caloric density (Cal/mL) Protein (% of total energy) Fat (% of total energy) Carbohydrate (% of total energy) Total Cal:g nitrogen ratio 304.8: :1 Non-protein Cal:g nitrogen ratio 279.8: :1 Water (g/l) Osmolality (mosm/kg water) Renal solute load (mosm/l) Viscosity at room temperature/ - - chilled Minimum tube size for gravity/ pump feeding (Fr) N/A N/A Low residue Gluten-free Kosher Halal AVAILABILITY Concentrated Liquid Similac Go & Grow 385-mL cans 12/case Powder 0S Similac Go & Grow 850-g cans 6/case Similar to other infant formulas. 58

59 ENERGY Per 100 ml Per 100 g Powder (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) 513 (2146) 68 (283) 100 (418) PROTEIN (g) % of total energy 8.2 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Skim milk, whey protein concentrate, whey protein hydrolysate FAT (g) % of total energy 48.8 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 11.9:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic sunflower oil, soy oil, coconut oil MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) % of total energy 43.0 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Lactose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 430 (1433) 57 (189) 83 (279) Vitamin D3 (mcg [IU]) 5.9 (236) 0.78 (31) 1.15 (46) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 122 (5.30) 16 (0.70) 24 (1.03) Potassium (mg [mmol]) 567 (14.54) 75 (1.92) 111 (2.83) Chloride (mg [mmol]) 300 (8.46) 40 (1.13) 58 (1.65) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION Nutritional information for Similac Go & Grow, Powder INGREDIENTS Similac Go & Grow, Powder: Skim milk, lactose, high oleic sunflower oil, soy oil, coconut oil, whey protein concentrate, potassium citrate, whey protein hydrolysate, calcium phosphate, calcium carbonate, soy lecithin, ascorbic acid, choline bitartrate, magnesium chloride, potas sium chloride, sodium chloride, ferrous sulphate, taurine, L-tryptophan, m-inositol, cytidine 5'-monophosphate, ascorbyl palmitate, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate, zinc sulphate, adenosine 5'-monophosphate, d-α-tocopheryl acetate, mixed tocopherols, niacinamide, L-carnitine, d-calcium pantothenate, vitamin A palmitate, cupric sulphate, thiamine hydrochloride, pyridoxine hydrochloride, riboflavin, manganese sulphate, β-carotene, folic acid, potassium iodide, phylloquinone, biotin, sodium selenate, vitamin D3, cyanocobalamin. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Coconut oil, lactose, other soy components. Similac Go & Grow, Concentrated Liquid: Water, lactose, dry or condensed skim milk, high oleic vegetable oil (safflower or sunflower), soy oil, coconut oil, whey protein concentrate, calcium phosphate, potassium citrate, calcium carbonate, monoglycerides, soy lecithin, potassium chloride, ascorbic acid, choline bitartrate, carrageenan, magnesium chloride, taurine, ferrous sulphate, potassium hydroxide, cytidine 5'-monophosphate, citric acid, d-α-tocopheryl acetate, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate, adenosine 5'-monophosphate, niacinamide, zinc sulphate, d-calcium pantothenate, vitamin A palmitate, thiamine chloride hydrochloride, riboflavin, cupric sulphate, pyridoxine hydrochloride, folic acid, phylloquinone, biotin, manganese sulphate, sodium selenate, vitamin D3, cyanocobalamin. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Coconut oil, citric acid, lactose, other soy components. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC GO & GROW Step 2 formula For infants and toddlers 6 to 24 months of age

60 SIMILAC IRON-FORTIFIED Step 1 formula For term infants 0+ months of age INDICATIONS FOR USE For initial or supplemental feeding of term infants. For oral or tube feeding use. Safety precaution: Not for parenteral use. FEATURES AND BENEFITS Unique blend of nucleotides (72 mg/l). No palm olein oil. Easy to digest. TECHNICAL DATA Concentrated Liquid (at standard dilution) Powder (at standard dilution) Caloric density (Cal/mL) Protein (% of total energy) Fat (% of total energy) Carbohydrate (% of total energy) Total Cal:g nitrogen ratio 304.8: :1 Non-protein Cal:g nitrogen ratio 279.8: :1 Water (g/l) Osmolality (mosm/kg water) Renal solute load (mosm/l) Viscosity at room temperature/ - - chilled Minimum tube size for gravity/ pump feeding (Fr) N/A N/A Low residue Gluten-free Kosher Halal AVAILABILITY Concentrated Liquid 0L Similac Iron-Fortified 385-mL cans 12/case Powder 0S Similac Iron-Fortified 850-g cans 6/case Similar to other infant formulas. 60

61 ENERGY Per 100 ml Per 100 g Powder (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) 513 (2146) 68 (283) 100 (418) PROTEIN (g) % of total energy 8.2 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Skim milk, whey protein concentrate, whey protein hydrolysate FAT (g) % of total energy 48.8 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 11.9:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic sunflower oil, soy oil, coconut oil MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) % of total energy 43.0 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Lactose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 430 (1433) 57 (189) 83 (279) Vitamin D3 (mcg [IU]) 5.9 (236) 0.78 (31) 1.15 (46) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) 122 (5.30) 16 (0.70) 24 (1.03) Potassium (mg [mmol]) 567 (14.54) 75 (1.93) 111 (2.83) Chloride (mg [mmol]) 300 (8.46) 40 (1.12) 58 (1.65) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) Nutritional information for Similac Iron-Fortified, Powder INGREDIENTS Similac Iron-Fortified, Powder: Skim milk, lactose, high oleic sunflower oil, soy oil, coconut oil, whey protein concentrate, potassium citrate, whey protein hydrolysate, calcium carbonate, soy lecithin, ascorbic acid, choline bitartrate, magnesium chloride, sodium chloride, potassium chloride, ferrous sulphate, taurine, L-tryptophan, m-inositol, cytidine 5'-monophosphate, ascorbyl palmitate, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate, zinc sulphate, adenosine 5'-monophosphate, d-α-tocopheryl acetate, mixed tocopherols, niacinamide, L-carnitine, d-calcium pantothenate, vitamin A palmitate, cupric sulphate, thiamine hydrochloride, pyridoxine hydrochloride, riboflavin, manganese sulphate, β-carotene, folic acid, potassium iodide, phylloquinone, biotin, sodium selenate, vitamin D3, cyanocobalamin. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Coconut oil, lactose, other soy components. Similac Iron-Fortified, Concentrated Liquid: ater, dry or condensed skim milk, lactose, high oleic vegetable oil (safflower or sunflower), soy oil, coconut oil, whey protein concentrate, calcium carbonate, potassium citrate, monoglycerides, soy lecithin, potassium chloride, ascorbic acid, choline bitartrate, carrageenan, magnesium chloride, ferrous sulphate, taurine, potassium hydroxide, m-inositol, cytidine 5'-monophosphate, citric acid, d-α-tocopheryl acetate, disodium guanosine 5'-monophosphate, zinc sulphate, disodium uridine 5'-monophosphate, adenosine 5'-monophosphate, niacinamide, calcium pantothenate, vitamin A palmitate, cupric sulphate, thiamine chloride hydrochloride, riboflavin, pyridoxine hydrochloride, folic acid, manganese sulphate, phylloquinone, biotin, sodium selenate, vitamin D3, cyanocobalamin. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Coconut oil, lactose, other soy components. NUTRITIONAL INFORMATION Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC IRON-FORTIFIED Step 1 formula For term infants 0+ months of age

62 SIMILAC LOWER IRON Step 1 formula For term infants 0+ months of age INDICATIONS FOR USE For initial or supplemental feeding of term infants. For infants whose health care professional wishes to provide a lower iron formulation. For oral or tube feeding use. Safety precaution: Not for parenteral use. FEATURES AND BENEFITS Lower iron content (0.65 mg/100 ml) than Similac Iron-Fortified. Unique blend of nucleotides (72 mg/l). No palm olein oil. Easy to digest. TECHNICAL DATA Concentrated Liquid (at standard dilution) Powder (at standard dilution) Caloric density (Cal/mL) Protein (% of total energy) Fat (% of total energy) Carbohydrate (% of total energy) Total Cal:g nitrogen ratio 304.8: :1 Non-protein Cal:g nitrogen ratio 279.8: :1 Water (g/l) Osmolality (mosm/kg water) Renal solute load (mosm/l) Viscosity at room temperature/ - - chilled Minimum tube size for gravity/ pump feeding (Fr) N/A N/A Low residue Gluten-free Kosher Halal AVAILABILITY Concentrated Liquid 0M Similac Lower Iron 385-mL cans 12/case Powder 0S Similac Lower Iron 850-g cans 6/case Similar to other infant formulas. 62

63 ENERGY Per 100 ml Per 100 g Powder (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) 513 (2146) 68 (283) 100 (418) PROTEIN (g) % of total energy 8.2 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Skim milk, whey protein concentrate, whey protein hydrolysate FAT (g) % of total energy 48.8 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 11.9 :1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic sunflower oil, soy oil, coconut oil MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) % of total energy 43.0 Total dietary fibre (g) Fructooligosaccharides (FOS) (g) Galactooligosaccharides (GOS) (g) Lactose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 430 (1433) 57 (189) 84 (279) Vitamin D3 (mcg [IU]) 5.9 (236) 0.78 (31) 1.15 (46) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 122 (5.30) 16 (0.70) 24 (1.03) Potassium (mg [mmol]) 567 (14.54) 75 (2.13) 111 (2.83) Chloride (mg [mmol]) 300 (8.46) 40 (1.13) 58 (1.65) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) Nutritional information for Similac Lower Iron, Powder INGREDIENTS Similac Lower Iron, Powder: Skim milk, lactose, high oleic sunflower oil, soy oil, coconut oil, whey protein concentrate, potassium citrate, whey protein hydrolysate, calcium carbonate, soy lecithin, ascorbic acid, choline bitartrate, magnesium chloride, sodium chloride, potassium chloride, taurine, L-tryptophan, m-inositol, ferrous sulphate, cytidine 5'-monophosphate, ascorbyl palmitate, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate, zinc sulphate, adenosine 5'-monophosphate, d-α-tocopheryl acetate, mixed tocopherols, niacinamide, L-carnitine, d-calcium pantothenate, vitamin A palmitate, cupric sulphate, thiamine hydrochloride, pyridoxine hydrochloride, riboflavin, manganese sulphate, β-carotene, folic acid, potassium iodide, phylloquinone, biotin, sodium selenate, vitamin D3, cyanocobalamin. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Coconut oil, lactose, other soy components. Similac Lower Iron, Concentrated Liquid: Water, evaporated or dry skim milk, lactose, high oleic safflower oil or high oleic sunflower oil, soy oil, coconut oil, whey protein concentrate, potassium citrate, calcium carbonate, monoglycerides, soy lecithin, potassium chloride, ascorbic acid, choline bitartrate, carrageenan, magnesium chloride, taurine, m-inositol, ferrous sulphate, cytidine 5'-monophosphate, d-α-tocopheryl acetate, disodium guanosine 5'-monophosphate, zinc sulphate, disodium uridine 5'-monophosphate, adenosine 5'-monophosphate, niacinamide, calcium pantothenate, vitamin A palmitate, cupric sulphate, thiamine chloride hydrochloride, riboflavin, pyridoxine hydrochloride, folic acid, manganese sulphate, phylloquinone, biotin, sodium selenate, vitamin D3, cyanocobalamin. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Coconut oil, lactose, other soy components. NUTRITIONAL INFORMATION Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC LOWER IRON Step 1 formula For term infants 0+ months of age

64 SIMILAC PARTIALLY BROKEN DOWN PROTEIN Step 1 partially hydrolyzed whey, DHA- and ARA-enriched formula For term infants 0+ months of age INDICATIONS FOR USE For initial or supplemental feeding of term infants. For oral or tube feeding use. Safety precaution: Not for parenteral use. FEATURES AND BENEFITS 100% whey protein that has been partially hydrolyzed. DHA (0.20% ), an Omega-3 fatty acid, and ARA (0.4% ), an Omega-6 fatty acid, to support the normal physical development of the brain and eyes. Unique blend of nucleotides (72 mg/l). No palm olein oil. Tummy-friendly and easy to digest. TECHNICAL DATA Powder (at standard dilution) Caloric density (Cal/mL) Protein (% of total energy) 9.2 Fat (% of total energy) 48.6 Carbohydrate (% of total energy) 42.2 Total Cal:g nitrogen ratio 261:1 Non-protein Cal:g nitrogen ratio 236:1 Water (g/l) 900 Osmolality (mosm/kg water) 180 Renal solute load (mosm/l) 156 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ N/A pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Powder C Similac Partially 638-g containers 6/case Broken Down Protein Of total fatty acids. Similar to other infant formulas. 64

65 ENERGY Per 100 ml Per 100 g Powder (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) 511 (2138) 67.6 (283) 100 (418) PROTEIN (g) % of total energy 9.2 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Whey protein hydrolysate FAT (g) % of total energy 48.6 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 10.16:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic safflower oil, coconut oil, soy oil, ARA and DHA MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) % of total energy 42.2 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Corn maltodextrin, sucrose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 460 (1532) 61 (203) 90 (300) Vitamin D3 (mcg [IU]) 7.66 (306) 1.01 (40.5) 1.50 (60) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 225 (9.78) 30 (1.30) 44 (1.92) Potassium (mg [mmol]) 660 (16.92) 87.4 (2.24) 129 (3.31) Chloride (mg [mmol]) 408 (11.51) 54 (1.52) 80 (2.24) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) INGREDIENTS Similac Partially Broken Down Protein, Powder: Corn maltodextrin, whey protein hydrolysate, high oleic safflower oil, sucrose, coconut oil, soy oil, calcium citrate, potassium phosphate monobasic, calcium phosphate tribasic, M. alpina oil*, potassium hydroxide, sodium chloride, magnesium chloride, ascorbic acid, C. cohnii oil**, potassium chloride, choline chloride, calcium hydroxide, taurine, choline bitartrate, m-inositol, ferrous sulphate, cytidine 5'-monophosphate, zinc sulphate, disodium guanosine 5'-monophosphate, ascorbyl palmitate, d-α tocopheryl acetate, L-carnitine, disodium uridine 5'-monophosphate, adenosine 5'-monophosphate, tocopherols, niacinamide, calcium pantothenate, potassium citrate, cupric sulphate, vitamin A palmitate, riboflavin, thiamine chloride hydrochloride, pyridoxine hydrochloride, manganese sulphate, folic acid, potassium iodide, phylloquinone, sodium selenate, biotin, vitamin D3, cyanocobalamin. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, lactose, other soy components. NUTRITIONAL INFORMATION Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC PARTIALLY BROKEN DOWN PROTEIN Step 1 partially hydrolyzed whey, DHA- and ARA-enriched formula For term infants 0+ months of age

66 SIMILAC SENSITIVE FOR BABIES SENSITIVE TO LACTOSE Step 1 formula For term infants 0+ months of age INDICATIONS FOR USE For infants with mild symptoms of lactose intolerance such as fussiness, gas and/or diarrhea. 1 For initial or supplemental feeding of term infants. For oral or tube feeding use. Safety precautions: Not for parenteral use. Not for infants with galactosemia, congenital lactase deficiency or confirmed cow s milk protein allergy. 2 FEATURES AND BENEFITS Cow s milk protein-based formula. Unique blend of two carbohydrates (corn syrup and sucrose) digested by separate enzyme systems which may help maximize absorption. 3 Clinically shown to support normal infant growth. 1 Unique blend of nucleotides (72 mg/l). No palm olein oil. Easy to digest. TECHNICAL DATA Concentrated Liquid (at standard dilution) Powder (at standard dilution) Caloric density (Cal/mL) Protein (% of total energy) Fat (% of total energy) Carbohydrate (% of total energy) Total Cal:g nitrogen ratio 289:1 289:1 Non-protein Cal:g nitrogen ratio 267:1 264:1 Water (g/l) Osmolality (mosm/kg water) Renal solute load (mosm/l) Viscosity at room temperature/ - - chilled Minimum tube size for gravity/ pump feeding (Fr) N/A N/A Low residue Gluten-free Kosher Halal AVAILABILITY Concentrated Liquid Similac Sensitive 385-mL cans 12/case for babies sensitive to lactose Powder Similac Sensitive 728-g cans 6/case for babies sensitive to lactose Similac Sensitive for babies sensitive to lactose formulation used in this study may differ slightly from the Canadian product. Similar to other infant formulas. REFERENCES: 1. Lasekan JB et al. Lactose-free Milk Protein-Based Formula: Impact on Growth and Gastrointestinal Tolerance in Infants. Clin Pediatr 2011;50(4): Nutrition for Healthy Term Infants: Recommendations from Birth to Six Months: A joint statement of Health Canada, Canadian Paediatric Society, Dietitians of Canada, and Breastfeeding Committee for Canada. Available from Accessed on August Kerzner B et al. Jejunal absorption of Sucrose (S) and Glucose Oligomers (GO) in the Absence of Pancreatic Amylase (PA). Pediatr Res 1983;17;191A. 66

67 ENERGY Per 100 ml Per 100 g Powder (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) 514 (2151) 68 (283) 100 (418) PROTEIN (g) % of total energy 8.7 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Milk protein isolate, whey protein hydrolysate FAT (g) % of total energy 49.1 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega :1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) 0,0 0,0 0,0 High oleic vegetable oil (safflower or sunflower), coconut oil, soy oil MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) % of total energy 42.2 Dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Corn syrup, sucrose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 430 (1433) 57 (189) 84 (279) Vitamin D3 (mcg [IU]) 7.63 (305) 1.00 (40) 1.48 (59) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 154 (6.70) 20 (0.87) 30 (1.30) Potassium (mg [mmol]) 620 (15.90) 82 (2.10) 121 (3.09) Chloride (mg [mmol]) 338 (9.53) 45 (1.27) 66 (1.85) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) Nutritional information for Similac Sensitive for babies sensitive to lactose, Powder INGREDIENTS Similac Sensitive for babies sensitive to lactose, Powder: Corn syrup, sucrose, milk protein isolate, high oleic vegetable oil (safflower or sunflower), coconut oil, soy oil, potassium citrate, calcium phosphate, whey protein hydrolysate, potassium chloride, calcium carbonate, sodium citrate, ascorbic acid, magnesium chloride, magnesium phosphate, choline chloride, choline bitartrate, ferrous sulphate, taurine, m-inositol, cytidine 5'-monophosphate, ascorbyl palmitate, disodium guanosine 5'-monophosphate, dl-α-tocopheryl acetate, disodium uridine 5'-monophosphate, L-carnitine, zinc sulphate, adenosine 5'-monophosphate, mixed tocopherols, niacinamide, potassium hydroxide, calcium pantothenate, copper sulphate, Vitamin A palmitate, thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, potassium iodide, folic acid, manganese sulphate, phylloquinone, biotin, sodium selenite, Vitamin D3, cyanocobalamin. May contain citric acid. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, lactose, other soy components, citric acid. Similac Sensitive for babies sensitive to lactose, Concentrated Liquid: Water, corn maltodextrin, sucrose, milk protein isolate, high oleic safflower or sunflower oil, coconut oil, soy oil, potassium citrate, calcium phosphate, modified corn starch, potassium chloride, magnesium chloride, monoglycerides, soy lecithin, carrageenan, sodium chloride, ascorbic acid, choline chloride, ferrous sulphate, choline bitartrate, taurine, m-inositol, cytidine 5l-monophosphate, dl-α-tocopheryl acetate, zinc sulphate, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate, adenosine 5'-monophosphate, L-carnitine, niacinamide, calcium pantothenate, cupric sulphate, vitamin A palmitate, thiamine chloride hydrochloride, pyridoxine hydrochloride, riboflavin, potassium iodide, folic acid, manganese sulphate, phylloquinone, biotin, sodium selenite, vitamin D3, cyanocobalamin. May contain potassium hydroxide, calcium carbonate, citric acid. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, citric acid, lactose, other soy components. NUTRITIONAL INFORMATION Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC SENSITIVE FOR BABIES SENSITIVE TO LACTOSE Step 1 formula For term infants 0+ months of age

68 SIMILAC SENSITIVE FOR BABIES SENSITIVE TO LACTOSE Step 1 formula For term infants 0+ months of age INDICATIONS FOR USE For infants with mild symptoms of lactose intolerance such as fussiness, gas and/or diarrhea. 1,2 For initial or supplemental feeding of term infants. For oral or tube feeding use. Safety precautions: Not for parenteral use. Not for infants with galactosemia, congenital lactase deficiency or confirmed cow's milk protein allergy. 1,3 FEATURES AND BENEFITS Cow's milk protein-based formula. Unique blend of two carbohydrates (corn syrup and sucrose) digested by separate enzyme systems which may help maximize absorption. 4 Clinically shown to support normal infant growth. 2 Unique blend of nucleotides (72 mg/l). No palm olein oil. Easy to digest. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 0.68 Protein (% of total energy) 8.8 Fat (% of total energy) 48.7 Carbohydrate (% of total energy) 42.5 Total Cal:g nitrogen ratio 287:1 Non-protein Cal:g nitrogen ratio 262:1 Water (g/l) 900 Osmolality (mosm/kg water) 218 Renal solute load (mosm/l) 136 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ N/A pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Similac Sensitive 59-mL 48/case for babies sensitive to lactose plastic bottles Similac Sensitive for babies sensitive to lactose formulation used in this study may differ slightly from the Canadian product. Similar to other infant formulas. REFERENCES: 1. Infant colic: Key Practice Points. Dietitians of Canada. Practice-Based Evidence in Nutrition. Last updated July Available from Accessed on August Lasekan JB et al. Lactose-free Milk Protein-Based Formula: Impact on Growth and Gastrointestinal Tolerance in Infants. Clin Pediatr 2011; 50(4): Nutrition for Healthy Term Infants: Recommendations from Birth to Six Months: A joint statement of Health Canada, Canadian Paediatric Society, Dietitians of Canada, and Breastfeeding Committee for Canada. Available from Accessed on August Kerzner B et al. Jejunal absorption of Sucrose (S) and Glucose Oligomers (GO) in the Absence of Pancreatic Amylase (PA). Pediatr Res 1983;17;191A. 68

69 ENERGY Per 100 ml Per 100 Cal Per 59 ml ENERGY (Cal [kj]) 68 (283) 100 (418) 40 (168) PROTEIN (g) % of total energy 8.8 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Total milk protein FAT (g) % of total energy 48.7 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 9.4:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) <1 <1.5 <0.6 High oleic safflower oil, coconut oil, soy oil MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) % of total energy 42.5 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Corn maltodextrin, sucrose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 60 (200) 88 (294) 35 (118) Vitamin D3 (mcg [IU]) 1.00 (40) 1.47 (59) 0.59 (24) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 20 (0.87) 29 (1.28) 12 (0.51) Potassium (mg [mmol]) 72 (1.85) 106 (2.71) 42 (1.09) Chloride (mg [mmol]) 44 (1.24) 65 (1.83) 26 (0.73) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION INGREDIENTS Similac Sensitive for babies sensitive to lactose, Ready to use: Water, corn maltodextrin, sucrose, milk protein isolate, high oleic safflower oil, coconut oil, soy oil, calcium phosphate tribasic, potassium citrate, carrageenan, ascorbic acid, potassium chloride, monoglycerides, soy lecithin, sodium citrate, calcium phosphate dibasic, magnesium chloride, magnesium phosphate dibasic, choline chloride, choline bitartrate, ferrous sulphate, taurine, m-inositol, cytidine 5'-monophosphate, dl-α-tocopheryl acetate, L-tryptophan, disodium guanosine 5'-monophosphate, disodium uridine 5'-monophosphate, adenosine 5'-monophosphate, zinc sulphate, L-carnitine, niacinamide, d-calcium pantothenate, riboflavin, vitamin A palmitate, thiamine hydrochloride, cupric sulphate, pyridoxine hydrochloride, manganese sulphate, folic acid, phylloquinone, potassium iodide, biotin, sodium selenite, vitamin D3, cyanocobalamin. May contain potassium hydroxide. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, citric acid, lactose, other soy components. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC SENSITIVE FOR BABIES SENSITIVE TO LACTOSE Step 1 formula For term infants 0+ months of age

70 SIMILAC ISOMIL WITH OMEGA-3 AND OMEGA-6 Step 1 soy-based, DHA- and ARA-enriched formula For infants 0+ months of age INDICATIONS FOR USE For infants with IgE-mediated cow s milk allergy where tolerance to soy has been established. 1,2 For infants whose parents wish to provide a non-milk-based formula for health, cultural, or religious reasons. For infants with lactase deficiency and/or sensitivity to lactose. For infants with galactosemia. For initial or supplemental feeding of term infants. For oral or tube feeding use. Safety precaution: Not for parenteral use. FEATURES AND BENEFITS Growth similar to that of infants fed breast milk or milk-based Similac. 3 Unique blend of two carbohydrates (corn syrup and sucrose) digested by separate enzyme systems which may help maximize absorption. 4 DHA (0.24% ), an Omega-3 fatty acid, and ARA (0.3% ), an Omega-6 fatty acid, to support the normal physical development of the brain and eyes. 5 Soy protein-based, cow's milk protein-free Naturally lactose-free. No milk or milk products. Contains nucleotides. No palm olein oil. Easy to digest. TECHNICAL DATA Powder (at standard dilution) Caloric density (Cal/mL) 0.66 Protein (% of total energy) 10.0 Fat (% of total energy) 48.0 Carbohydrate (% of total energy) 42.0 Total Cal:g nitrogen ratio 251:1 Non-protein Cal:g nitrogen ratio 226:1 Water (g/l) 901 Osmolality (mosm/kg water) 200 Renal solute load (mosm/l) 162 Viscosity at room temperature/ N/A chilled Minimum tube size for gravity/ N/A pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Powder 0S Similac Isomil 800-g cans 6/case with Omega-3 and Omega-6 Comparison based on previous formulations of Similac Iron-Fortified and Similac Isomil. Of total fatty acids. Inherent sources. Similar to other infant formulas. REFERENCES: 1. Leung A, Otley A. Canadian Paediatric Society: Nutrition and Gastroenterology Committee. Concerns for the use of soy-based formulas in infant nutrition. Pediatric Child Health. 2009;14(3): [Reaffirmed: Jan 30, 2013]. 2. Nutrition for Healthy Term Infants: Recommendations from Birth to Six Months: A joint statement from Health Canada, Canadian Paediatric Society, Dietitians of Canada, and Breastfeeding Committee for Canada. Last modified in August Accessed in December Lasekan JB et al. Growth of Newborn, Term Infants Fed Soy Formulas For 1 Year. Clin Pediatr 1999; Kerzner B et al. Jejunal absorption of sucrose and glucose oligomers in the absence of pancreatic amylase. Pediatr Res 1983;17;191A. 5. Canadian Food Inspection Agency: Guide to Food Labeling and Advertising, Chapter 8. Available at: 3/ ?chap=8+-+s16c8. Accessed in August

71 ENERGY Per 100 ml Per 100 g Powder (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) (2111.3) 66 (278) 100 (418) PROTEIN (g) % of total energy 10.0 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Soy protein isolate FAT (g) % of total energy 48.0 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 9.1:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic sunflower oil, coconut oil, soy oil, ARA and DHA MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) % of total energy 42.0 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Corn syrup, sucrose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 459 (1530) 60 (201) 90 (303) Vitamin D3 (mcg [IU]) 6.5 (259) 1 (34) 1.28 (51) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 219 (9.91) 29 (1.30) 43 (1.89) Potassium (mg [mmol]) 520 (14.23) 68 (1.87) 103 (2.64) Chloride (mg [mmol]) 404 (9.0) 53 (1.18) 80 (2.25) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) INGREDIENTS Similac Isomil with Omega-3 and Omega-6, Powder: Corn syrup, soy protein isolate, high oleic sunflower oil, sucrose, coconut oil, soy oil, calcium phosphate, potas sium citrate, soy lecithin, sodium chloride, potassium chloride, magnesium chloride, *M. alpina oil, **C. cohnii oil, L-methionine, m-inositol, ascorbic acid, choline chloride, taurine, ascorbyl palmitate, L-tryptophan, zinc sulphate, ferrous sulphate, L-carnitine, mixed tocopherols, niacinamide, calcium d-pantothenate, d-α-tocopheryl acetate, vitamin A palmitate, riboflavin, thiamine hydrochloride, cupric sulphate, pyridoxine hydrochloride, potassium iodide, folic acid, phylloquinone, sodium selenite, biotin, vitamin D3, cyanocobalamin. May contain calcium carbonate, potassium phosphate, sodium citrate and manganese sulphate. CONTAINS: Priority food allergens: Soy. Ingredients associated with food intolerances and/ or sensitivities: Corn, coconut oil, other soy components. Contains no dairy ingredients. Manufactured on dairy equipment. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). NUTRITIONAL INFORMATION Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC ISOMIL WITH OMEGA-3 AND OMEGA-6 Step 1 soy-based, DHA- and ARA-enriched formula For infants 0+ months of age

72 SIMILAC ISOMIL OMEGA-3 AND OMEGA-6 Step 1 soy-based, DHA- and ARA-enriched formula For infants 0+ months of age INDICATIONS FOR USE For infants with IgE-mediated cow s milk allergy where tolerance to soy has been established. 1,2 For infants whose parents wish to provide a non-milk-based formula for health, cultural or religious reasons. For infants with lactase deficiency and/or sensitivity to lactose. For infants with galactosemia. For initial or supplemental feeding of term infants. For oral or tube feeding use. Safety precautions: Not for parenteral use. For infants with galactosemia, Similac Isomil Omega-3 and Omega-6 powder is the preferred format. FEATURES AND BENEFITS Growth similar to that of infants fed breast milk or milk-based Similac. 3 Unique blend of two carbohydrates (corn syrup and sucrose) digested by separate enzyme systems which may help maximize absorption. 4 Contains DHA (0.15% ), an Omega-3 fatty acid, and ARA (0.4% ), an Omega-6 fatty acid, to support the normal physical development of the brain and eyes. 5 Soy protein-based, cow milk protein-free. Naturally lactose free. No milk or milk products. Contains nucleotides. No palm olein oil. Easy to digest. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 0.68 Protein (% of total energy) 9.8 Fat (% of total energy) 49.0 Carbohydrate (% of total energy) 41.2 Total Cal:g nitrogen ratio 256:1 Non-protein Cal:g nitrogen ratio 230:1 Water (g/l) 903 Osmolality (mosm/kg water) 219 Renal solute load (mosm/l) 151 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ N/A pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Similac Isomil 59-mL 48/case Omega-3 and Omega-6 plastic bottles Comparison based on previous formulations of Similac Iron-Fortified and Similac Isomil. Of total fatty acids. Inherent sources. Similar to other infant formulas. REFERENCES: 1. Leung A, Otley A. Canadian Paediatric Society: Nutrition and Gastroenterology Committee. Concerns for the use of soy-based formulas in infant nutrition. Pædiatr Child Health 2009;14(3): [Reaffirmed: Jan 30, 2013]. 2. Nutrition for Healthy Term Infants: Recommendations from Birth to Six Months: A joint statement from Health Canada, Canadian Paediatric Society, Dietitians of Canada, and Breastfeeding Committee for Canada. Last modified in August Available at nutrition/infant-nourisson/recom/index-eng.php. Accessed in December Lasekan JB et al. Growth of Newborn, Term Infants Fed Soy Formulas For 1 Year. Clin Pediatr 1999; Kerzner B et al. Jejunal absorption of sucrose and glucose oligomers in the absence of pancreatic amylase. Pediatr Res 1983;17;191A. 5. Canadian Food Inspection Agency: Guide to food labeling and advertising health claims (chap. 8). Available at: health-claims/eng/ / ?chap=8+-+s16c8. Accessed in August

73 ENERGY Per 100 ml Per 100 Cal Per 59 ml ENERGY (Cal [kj]) 68 (283) 100 (418) 40 (168) PROTEIN (g) % of total energy 9.8 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Soy protein isolate FAT (g) % of total energy 49.1 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 8.9:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic safflower oil, soy oil, coconut oil, DHA and ARA MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) % of total energy 41.2 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Corn syrup, sucrose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 57 (189) 83 (278) 34 (112) Vitamin D3 (mcg [IU]) 0.90 (36) 1.32 (53) 0.53 (21) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 27 (1.17) 40 (1.73) 16 (0.69) Potassium (mg [mmol]) 92 (2.36) 135 (3.47) 54 (1.39) Chloride (mg [mmol]) 40 (1.13) 59 (1.66) 24 (0.67) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION INGREDIENTS Similac Isomil Omega-3 and Omega-6, Ready to use: Water, corn syrup, soy protein isolate, high oleic safflower oil, sucrose, soy oil, coconut oil, calcium citrate, calcium phosphate, ascorbic acid, potassium phosphate dibasic, potassium phosphate monobasic, magnesium chloride, monoglyceride, soy lecithin, *M. alpina oil, potassium chloride, L-methionine, potassium citrate, choline bitartrate, **C. cohnii oil, carrageenan, sodium citrate, sodium chloride, L-tryptophan, taurine, ferrous sulphate, inositol, zinc sulphate, d-α-tocopherylacetate, L-carnitine tartrate, calcium d-pantothenate, niacinamide, vitamin A palmitate, cupric sulphate, riboflavin, thiamine hydrochloride, pyridoxine hydrochloride, manganese sulphate, potassium iodide, folic acid, phylloquinone, sodium selenate, biotin, vitamin D3, cyanocobalamin. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). CONTAINS: Priority food allergens: Soy. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, citric acid, other soy components. Contains no dairy ingredients. Manufactured on dairy equipment. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC ISOMIL OMEGA-3 AND OMEGA-6 Step 1 soy-based, DHA- and ARA-enriched formula For infants 0+ months of age

74 SIMILAC ISOMIL Step 1 soy-based, iron-fortified formula For infants 0+ months of age INDICATIONS FOR USE For infants with IgE-mediated cow s milk allergy where tolerance to soy has been established. 1,2 For infants whose parents wish to provide a non-milk-based formula for health, cultural, or religious reasons. For infants with lactase deficiency and/or sensitivity to lactose. For infants with galactosemia. For initial or supplemental feeding of term infants. For oral or tube feeding use. Safety precaution: Not for parenteral use. FEATURES AND BENEFITS Growth similar to that of infants fed breast milk or milk-based Similac. 3 Unique blend of two carbohydrates (corn syrup and sucrose) digested by separate enzyme systems which may help maximize absorption. 4 Soy protein-based, cow's milk protein-free. Naturally lactose-free. No milk or milk products. Contains nucleotides. No palm olein oil. Easy to digest. TECHNICAL DATA Powder (at standard dilution) Caloric density (Cal/mL) 0.68 Protein (% of total energy) 9.7 Fat (% of total energy) 48.8 Carbohydrate (% of total energy) 41.5 Total Cal:g nitrogen ratio 258:1 Non-protein Cal:g nitrogen ratio 233:1 Water (g/l) 901 Osmolality (mosm/kg water) 218 Renal solute load (mosm/l) 154 Viscosity at room temperature/ N/A chilled Minimum tube size for gravity/ N/A pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Powder 0L Similac Isomil 800-g cans 6/case Comparison based on previous formulation of Similac Iron-Fortified. Inherent sources. Similar to other infant formulas. REFERENCES: 1. Leung A, Otley A. Canadian Paediatric Society: Nutrition and Gastroenterology Committee. Concerns for the use of soy-based formulas in infant nutrition. Paediatr Child Health. 2009;14(3): [Reaffirmed: Jan 30, 2013]. 2. Nutrition for Healthy Term Infants: Recommendations from Birth to Six Months: A joint statement from Health Canada, Canadian Paediatric Society, Dietitians of Canada, and Breastfeeding Committee for Canada. Last modified in August Available at fn-an/nutrition/infant-nourisson/recom/index-eng.php. Accessed in December Lasekan JB et al. Growth of Newborn, Term Infants Fed Soy Formulas For 1 Year. Clin Pediatr 1999; Kerzner B et al. Jejunal absorption of sucrose and glucose oligomers in the absence of pancreatic amylase. Pediatr Res 1983;17;191A. 74

75 ENERGY Per 100 ml Per 100 g Powder (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) 516 (2158) 68 (284) 100 (418) PROTEIN (g) % of total energy 9.7 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Soy protein isolate FAT (g) % of total energy 48.8 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 11.0:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic sunflower oil or high oleic safflower oil, coconut oil, soy oil MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) % of total energy 41.5 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Corn syrup, sucrose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 456 (1521) 60 (200) 88 (294) Vitamin D3 (mcg [IU]) 7.6 (304) 1 (40) 1.47 (59) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 228 (9.91) 30 (1.30) 44 (1.92) Potassium (mg [mmol]) 555 (14.23) 73 (1.87) 107 (2.75) Chloride (mg [mmol]) 319 (9.0) 42 (1.18) 62 (1.74) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) INGREDIENTS Similac Isomil, Powder: Corn syrup, sucrose, soy protein isolate, high oleic sunflower oil, coconut oil, soy oil, calcium phosphate tribasic, potassium citrate, sodium chloride, magnesium chloride, L-methionine, choline bitartrate, ascorbic acid, taurine, potassium chloride, ascorbyl palmitate, ferrous sulphate, dl-α-tocopheryl acetate, L-carnitine tartrate, zinc sulphate, niacinamide, mixed tocopherols, calcium d-pantothenate, vitamin A palmitate, cupric sulphate, riboflavin, thiamine hydrochloride, pyridoxine hydrochloride, b-carotene, manganese sulphate, folic acid, potassium iodide, phylloquinone, biotin, sodium selenite, vitamin D3, cyanocobalamin. May contain L-carnitine, calcium carbonate, potassium phosphate dibasic, sodium citrate and choline chloride. CONTAINS: Priority food allergens: Soy. Ingredients associated with food intolerances and/ or sensitivities: Corn, coconut oil, other soy components. Contains no dairy ingredients. Manufactured on dairy equipment. NUTRITIONAL INFORMATION Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC ISOMIL Step 1 soy-based, iron-fortified formula For infants 0+ months of age

76 SIMILAC ISOMIL Step 2 soy-based formula with iron For infants and toddlers 6 to 24 months of age INDICATIONS FOR USE Transition formula for term infants who are 6 months or older. For infants with IgE-mediated cow s milk allergy where tolerance to soy has been established. 1,2 For infants whose parents wish to provide a non-milk-based formula for health, cultural, or religious reasons. For infants with lactase deficiency and/or sensitivity to lactose. For infants with galactosemia. For oral or tube feeding use. Safety precaution: Not for parenteral use. FEATURES AND BENEFITS Specially formulated to help bridge the nutritional intake gaps that can be associated with the transition to table foods. Provides 29% more calcium and 20% more phosphorus than Similac Isomil (Step 1). Growth similar to that of infants fed breast milk or milk-based Similac. 3 Unique blend of two carbohydrates (corn syrup and sucrose) digested by separate enzyme systems which may help maximize absorption. 4 Soy protein-based, cow's milk protein-free. Naturally lactose-free. No milk or milk products. Contains nucleotides. No palm olein oil. TECHNICAL DATA Powder (at standard dilution) Caloric density (Cal/mL) 0.68 Protein (% of total energy) 9.7 Fat (% of total energy) 48.8 Carbohydrate (% of total energy) 41.5 Total Cal:g nitrogen ratio 258:1 Non-protein Cal:g nitrogen ratio 233:1 Water (g/l) 901 Osmolality (mosm/kg water) 215 Renal solute load (mosm/l) 157 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ N/A pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Powder 0P Similac Isomil (Step 2) 800-g cans 6/case Comparison based on previous formulation of Similac Iron-Fortified. Inherent sources. REFERENCES: 1. Leung A, Otley A. Canadian Paediatric Society: Nutrition and Gastroenterology Committee. Concerns for the use of soy-based formulas in infant nutrition. Paediatr Child Health. 2009;14(3): [Reaffirmed: Jan 30, 2013]. 2. Nutrition for Healthy Term Infants: Recommendations from Birth to Six Months: A joint statement from Health Canada, Canadian Paediatric Society, Dietitians of Canada, and Breastfeeding Committee for Canada. Last modified in August Available at fn-an/nutrition/infant-nourisson/recom/index-eng.php. Accessed in December Lasekan JB et al. Growth of Newborn, Term Infants Fed Soy Formulas For 1 Year. Clin Pediatr 1999; Kerzner B et al. Jejunal absorption of sucrose and glucose oligomers in the absence of pancreatic amylase. Pediatr Res 1983;17;191A. 76

77 ENERGY Per 100 ml Per 100 g Powder (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) 516 (2158) 68 (284) 100 (418) PROTEIN (g) % of total energy 9.7 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Soy protein isolate FAT (g) % of total energy 48.8 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 11.0:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic safflower oil or high oleic sunflower oil, coconut oil, soy oil MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) % of total energy 41.5 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Corn syrup, sucrose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 456 (1521) 60 (200) 88 (294) Vitamin D3 (mcg [IU]) 7.6 (304) 1 (40) 147 (59) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 228 (9.91) 30 (1.30) 44 (1.92) Potassium (mg [mmol]) 555 (14.23) 73 (1.87) 107 (2.75) Chloride (mg [mmol]) 319 (9.00) 42 (1.18) 62 (1.74) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION INGREDIENTS Similac Isomil (Step 2), Powder: Corn syrup, sucrose, soy protein isolate, high oleic sunflower oil, coconut oil, soy oil, calcium phosphate tribasic, potassium citrate, sodium chloride, magnesium chloride, L-methionine, choline bitartrate, ascorbic acid, potassium chloride, taurine, ascorbyl palmitate, ferrous sulphate, dl-α-tocopheryl acetate, L-carnitine tartrate, zinc sulphate, niacinamide, mixed tocopherols, calcium d-pantothenate, vitamin A palmitate, cupric sulphate, riboflavin, thiamine hydrochloride, pyridoxine hydrochloride, β-carotene, manganese sulphate, folic acid, potassium iodide, phylloquinone, biotin, sodium selenite, vitamin D3, cyanocobalamin. May contain L-carnitine, calcium carbonate, potassium phosphate dibasic, sodium citrate and choline chloride. CONTAINS: Priority food allergens: Soy. Ingredients associated with food intolerances and/ or sensitivities: Corn, coconut oil, other soy components. Contains no dairy ingredients. Manufactured on dairy equipment. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC ISOMIL Step 2 soy-based formula with iron For infants and toddlers 6 to 24 months of age

78 SIMILAC 24 WITH IRON Hypercaloric formula For term infants 0+ months of age INDICATIONS FOR USE For infants with increased caloric needs. For volume restricted infants. For oral or tube feeding use. Safety precautions: Use under medical supervision. Not for parenteral use. FEATURES AND BENEFITS Increased caloric density: provides 81 Cal per 100 ml (24 Cal/30 ml). No palm olein oil. Easy to digest. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 0.81 Protein (% of total energy) 8.3 Fat (% of total energy) 49.4 Carbohydrate (% of total energy) 42.3 Total Cal:g nitrogen ratio 301:1 Non-protein Cal:g nitrogen ratio 275:1 Water (g/l) 884 Osmolality (mosm/kg water) 375 Renal solute load (mosm/l) 156 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ N/A pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Similac 24 with Iron 59-mL 48/case plastic bottles Similar to other infant formulas. 78

79 ENERGY Per 100 ml Per 100 Cal Per 59 ml ENERGY (Cal [kj]) 81 (340) 100 (418) 48 (200) PROTEIN (g) % of total energy 8.3 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Dry skim milk, whey protein concentrate FAT (g) % of total energy 49.4 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 10.4:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic safflower oil, coconut oil, soy oil MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) % of total energy 42.3 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Lactose Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 72 (240) 89 (296) 42 (142) Vitamin D3 (mcg [IU]) 1.05 (42) 1.30 (52) 0.62 (25) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) 22 (0.96) 27 (1.18) 13 (0.56) Potassium (mg [mmol]) 95 (2.44) 117 (3.01) 56 (1.44) Chloride (mg [mmol]) 53 (1.50) 65 (1.85) 31 (0.88) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION INGREDIENTS Similac 24 with Iron, Ready to use: Water, lactose, dry or condensed skim milk, high oleic safflower oil, coconut oil, soy oil, whey protein concentrate, ascorbic acid, calcium carbonate, potassium citrate, monoglycerides, soy lecithin, sodium citrate, potassium chloride, magnesium chloride, calcium phosphate, carrageenan, potassium phosphate, choline chloride, ferrous sulphate, taurine, m-inositol, citric acid, L-tryptophan, d-α-tocopheryl acetate, zinc sulphate, niacinamide, calcium d-pantothenate, L-carnitine, cupric sulphate, vitamin A palmitate, thiamine chloride hydrochloride, riboflavin, pyridoxine hydrochloride, folic acid, phylloquinone, manganese sulphate, biotin, vitamin D3, cyano cobalamin. May contain sodium selenate, magnesium sulphate, sodium chloride, potassium iodide, potassium hydroxide. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Coconut oil, citric acid, lactose, other soy components. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC 24 WITH IRON Hypercaloric formula For term infants 0+ months of age

80 SIMILAC ALIMENTUM OMEGA-3 AND OMEGA-6 Hypoallergenic, extensively hydrolyzed formula For infants 0+ months of age Now available in powder format INDICATIONS FOR USE A nutritionally complete, hypoallergenic formula for infants with: - Colic symptoms due to protein sensitivity (cow s milk and/or soy protein) - Sensitivity to intact protein (cow s milk and/or soy protein) - Severe food allergies - Protein maldigestion - Fat malabsorption For initial or supplemental feeding of term infants. For oral or tube feeding. Safety precautions: Not for parenteral use. FEATURES AND BENEFITS Similac Alimentum fulfills the accepted international medical standard for a hypoallergenic product. 1,2 Hypoallergenic does not mean non -allergenic. Extensively hydrolyzed casein, supplemented with free amino acids for infants who are sensitive to or unable to digest intact protein. Unique blend of carbohydrates digested by separate enzyme systems which may help maximize absorption. 3 Contains DHA (0.2% ), an Omega-3 fatty acid, and ARA (0.4% ), an Omega-6 fatty acid, to support the normal physical development of the brain and eyes. 4 Approximately 33% of fat as medium-chain triglycerides, an easily digested and well-absorbed fat source. 5 Lactose-free carbohydrate for lactose sensitivity. No palm olein oil. Easy to digest. TECHNICAL DATA Powder (at standard dilution) Caloric density (Cal/mL) 0.68 Protein (% of total energy) 11.0 Fat (% of total energy) 48.6 Carbohydrate (% of total energy) 40.4 Total Cal:g nitrogen ratio 230:1 Non-protein Cal:g nitrogen ratio 205:1 Water (g/l) 892 Osmolality (mosm/kg water) 274 Renal solute load (mosm/l) 171 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ N/A pump feeding (Fr) Low residue Gluten-free Kosher Halal No No AVAILABILITY Powder Similac Alimentum 400-g cans 6/case Omega-3 and Omega-6 Extensively broken down to small peptides and amino acid components to minimize the potential for allergic reaction. Of total fatty acids. Similar to other infant formulas. REFERENCES: 1. Kleinman RE et al. Use of infant formulas in infants with cow milk allergy: a review and recommendations. Pediatr Allergy Immunol 1991;2: American Academy of Pediatrics. Committee on Nutrition. Hypoallergenic Infant Formulas. Pediatrics 2000;106(2): Kerzner B et al. Jejunal absorption of sucrose and glucose oligomers in the absence of pancreatic amylase. Pediatr Res 1983;17;191A. 4. Canadian Food Inspection Agency: Guide to food labeling and advertising health claims (chap. 8). Available at: Accessed January, Duggan C, Watkins JB and Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton

81 ENERGY Per 100 ml Per 100 g Powder (at standard dilution) Per 100 Cal ENERGY (Cal [kj]) 517 (2163) 67.6 (283) 100 (418) PROTEIN (g) % of total energy 11 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Nucleotides (mg) Casein hydrolysate, free amino acids FAT (g) % of total energy 48.6 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio 9.44:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic safflower oil, MCT oil, soy oil, ARA and DHA MCT oil (% of total fats) 33 CARBOHYDRATE (g) % of total energy 40.4 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Corn maltodextrin, sucrose, modified corn starch Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 465 (1550) 60.8 (203) 90.0 (300) Vitamin D3 (mcg [IU]) 7.75 (310) 1.01 (41.0) 1.50 (60.0) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) MINERALS Sodium (mg [mmol]) 227 (9.87) 30.0 (1.30) 43.9 (1.91) Potassium (mg [mmol]) 610 (15.64) 80.0 (2.06) 118 (3.03) Chloride (mg [mmol]) 413 (11.65) 54.0 (1.53) 80 (2.25) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION INGREDIENTS Similac Alimentum Omega-3 and Omega-6, Powder: Corn maltodextrin, casein hydrolysate (derived from milk), high oleic safflower oil, medium chain triglycerides (modified coconut and/or palm kernel oils), sucrose, soy oil, modified corn starch, calcium citrate, calcium phosphate, potassium citrate, xanthan gum, potassium phosphate, *M. alpina oil, L-tyrosine, magnesium chloride, L-cystine hydrochloride, sodium chloride, ascorbic acid, **C. cohnii oil, L-tryptophan, choline chloride, ferrous sulphate, potassium chloride, taurine, m-inositol, dl-α-tocopheryl acetate, ascorbyl palmitate, zinc sulphate, L-carnitine, mixed tocopherols, niacinamide, calcium pantothenate, cupric sulphate, vitamin A palmitate, riboflavin, thiamine chloride hydrochloride, pyridoxine hydrochloride, folic acid, potassium iodide, phylloquinone, biotin, sodium selenite, vitamin D3, cyanocobalamin. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, citric acid, other soy components. Similac Alimentum contains a pre-digested protein (casein hydrolysate). This hypoallergenic formula is specifically designed for infants and children who cannot tolerate milk- or soy-based formulas. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC ALIMENTUM OMEGA-3 AND OMEGA-6 Hypoallergenic, extensively hydrolyzed formula For infants 0+ months of age

82 SIMILAC ALIMENTUM Hypoallergenic, extensively hydrolyzed formula For infants 0+ months of age INDICATIONS FOR USE A nutritionally complete, hypoallergenic formula for infants with: - Colic symptoms due to protein sensitivity (cow s milk and/or soy protein) - Sensitivity to intact protein (cow s milk and/or soy protein) - Severe food allergies - Protein maldigestion - Fat malabsorption For initial or supplemental feeding. For oral or tube feeding. Safety precautions: Not for parenteral use. FEATURES AND BENEFITS Similac Alimentum fulfills the accepted international medical standard for a "hypoallergenic" product. 1,2 Hypoallergenic does not mean non -allergenic. Extensively hydrolyzed casein, supplemented with free amino acids for infants who are sensitive to or unable to digest intact protein. Unique blend of two carbohydrates (sucrose and modified tapioca starch) using two absorptive pathways to help maximize absorption and minimize risk of malabsorption. 3 Approximately 33% of fat as medium-chain triglycerides, an easily digested and well-absorbed fat source. 4 Lactose-free carbohydrate for lactose sensitivity. No palm olein oil. Easy to digest. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 0.68 Protein (% of total energy) 11 Fat (% of total energy) 49 Carbohydrate (% of total energy) 40 Total Cal:g nitrogen ratio N/A Non-protein Cal:g nitrogen ratio N/A Water (g/l) 900 Osmolality (mosm/kg water) 370 Renal solute load (mosm/l) 123 Viscosity at room temperature/ Thin/thin chilled Minimum tube size for gravity/ 5/5 pump feeding (Fr) Low residue Gluten-free Kosher Halal No No AVAILABILITY Ready to use Similac Alimentum 237-mL cans 6 x 4/case Extensively broken down to small peptides and amino acid components to minimize the potential for allergic reaction. Similar to other infant formulas. REFERENCES: 1. Kleinman RE et al. Use of infant formulas in infants with cow milk allergy: a review and recommendations. Pediatr Allergy Immunol 1991;2: American Academy of Pediatrics. Committee on Nutrition. Hypoallergenic Infant Formulas. Pediatrics 2000;106(2): Kerzner B et al. Jejunal absorption of sucrose and glucose oligomers in the absence of pancreatic amylase. Pediatr Res 1983;17;191A. 4. Duggan C, Watkins JB and Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton

83 ENERGY Per 100 ml Per 100 Cal Per 237 ml ENERGY (Cal [kj]) 68 (285) 100 (418) 161 (674) PROTEIN (g) % of total energy 11 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Casein hydrolysate, free amino acids FAT (g) % of total energy 49 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio N/A Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) Safflower oil, MCT oil, soy oil MCT oil (% of total fats) 33 CARBOHYDRATE (g) % of total energy 40 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Sucrose, modified tapioca starch Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 61 (203) 90 (300) 144 (481) Vitamin D3 (mcg [IU]) 0.75 (30) 1.13 (45) 1.78 (71) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) 30 (1.30) 44 (1.91) 71 (3.09) Potassium (mg [mmol]) 80 (2.05) 118 (3.03) 190 (4.86) Chloride (mg [mmol]) 54 (1.52) 80 (2.26) 128 (3.61) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION INGREDIENTS Similac Alimentum, Ready to use: Water, sucrose, casein hydrolysate (derived from milk), modified tapioca starch, safflower oil, medium chain -triglycerides (modified coconut oil and/or palm kernel oil), soy oil, calcium citrate, calcium phosphate, carrageenan, potassium phosphate, ascorbic acid, magnesium chloride, calcium hydroxide, sodium chloride, potassium chloride, L-cystine dihydrochloride, potassium citrate, L-tyrosine, choline chloride, L-tryptophan, ferrous sulphate, taurine, m-inositol, dl-α-tocopheryl acetate, zinc sulphate, L-carnitine, -niacinamide, calcium pantothenate, vitamin A palmitate, cupric sulphate, thiamine chloride hydrochloride, riboflavin, pyridoxine -hydrochloride, folic acid, potassium iodide, phylloquinone, biotin, sodium selenate, vitamin D3, cyanocobalamin. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Coconut oil, other soy components. Similac Alimentum contains a pre-digested protein (casein hydrolysate). This hypoallergenic formula is specifically designed for infants and children who cannot tolerate milk- or soy-based formulas. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC ALIMENTUM Hypoallergenic, extensively hydrolyzed formula For infants 0+ months of age

84 SIMILAC ALIMENTUM OMEGA-3 AND OMEGA-6 Hypoallergenic, extensively hydrolyzed formula For infants 0+ months of age INDICATIONS FOR USE A nutritionally complete, hypoallergenic formula for infants with: - Colic symptoms due to protein sensitivity (cow s milk and/or soy protein) - Sensitivity to intact protein (cow s milk and/or soy protein) - Severe food allergies - Protein maldigestion - Fat malabsorption For initial or supplemental feeding. For oral or tube feeding. Safety precautions: Not for parenteral use. FEATURES AND BENEFITS Similac Alimentum fulfills the accepted international medical standard for a "hypoallergenic" product. 1,2 Hypoallergenic does not mean non -allergenic. Extensively hydrolyzed casein, supplemented with free amino acids for infants who are sensitive to or unable to digest intact protein. Unique blend of two carbohydrates (sucrose and modified tapioca starch) using two absorptive pathways to help maximize absorption and minimize risk of malabsorption. 3 Contains DHA (0.15% ), an Omega-3 fatty acid, and ARA (0.4% ), an Omega-6 fatty acid, to support the normal physical development of the brain and eyes. Approximately 33% of fat as medium-chain triglycerides, an easily digested and well-absorbed fat source. 4 Lactose-free carbohydrate for lactose sensitivity. No palm olein oil. Easy to digest. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 0.68 Protein (% of total energy) 11 Fat (% of total energy) 48 Carbohydrate (% of total energy) 41 Total Cal:g nitrogen ratio N/A Non-protein Cal:g nitrogen ratio N/A Water (g/l) 899 Osmolality (mosm/kg water) 370 Renal solute load (mosm/l) Viscosity at room temperature/ - chilled Minimum tube size for gravity/ 5/5 pump feeding (Fr) Low residue Gluten-free Kosher Halal No No AVAILABILITY Ready to use Similac Alimentum 59-mL plastic 48/case Omega-3 and Omega-6 bottles Extensively broken down to small peptides and amino acid components to minimize the potential for allergic reaction. Of total fatty acids. Similar to other infant formulas. REFERENCES: 1. Kleinman RE et al. Use of infant formulas in infants with cow milk allergy: a review and recommendations. Pediatr Allergy Immunol 1991;2: American Academy of Pediatrics. Committee on Nutrition. Hypoallergenic Infant Formulas. Pediatrics 2000;106(2): Kerzner B et al. Jejunal absorption of sucrose and glucose oligomers in the absence of pancreatic amylase. Pediatr Res 1983;17;191A. 4. Duggan C, Watkins JB and Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton

85 ENERGY Per 100 ml (at standard dilution) Per 100 Cal Per 59 ml ENERGY (Cal [kj]) 68 (283) 100 (418) 40 (168) PROTEIN (g) % of total energy 11 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Casein hydrolysate, free amino acids FAT (g) % of total energy 48 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) Linolenic acid (g) Docosahexaenoic acid (DHA) (g) Omega-6:Omega-3 ratio N/A Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) Safflower oil, MCT oil, soy oil MCT oil (% of total fats) 33 CARBOHYDRATE (g) % of total energy 41 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) Sucrose, modified tapioca starch Acesulfame-potassium (mg) Sucralose (mg) VITAMINS Vitamin A (RE [IU]) 61 (203) 90 (300) 36 (120) Vitamin D3 (mcg [IU]) 0.75(30) 1.10 (45) 0.44 (18) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) 30 (1.30) 44 (1.92) 18 (0.77) Potassium (mg [mmol]) 80 (2.05) 118 (3.02) 47 (1.21) Chloride (mg [mmol]) 54 (1.52) 80 (2.24) 32 (0.90) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION INGREDIENTS Similac Alimentum Omega-3 and Omega-6, Ready to use: Water, sucrose, casein hydrolysate (derived from milk), modified tapioca starch, safflower oil, medium chain triglycerides (modified coconut and/or palm kernel oils), soy oil, calcium citrate, calcium phosphate, carrageenan, ascorbic acid, potassium phosphate, magnesium chloride, *M. alpina oil, potassium citrate, sodium chloride, calcium hydroxide, potassium hydroxide, L-cystine dihydrochloride, potassium chloride, **C. cohnii oil, L-tyrosine, L-tryptophan, choline chloride, ferrous sulphate, taurine, m-inositol, zinc sulphate, dl-α-tocopheryl acetate, L-carnitine, niacinamide, calcium pantothenate, cupric sulphate, vitamin A palmitate, thiamine chloride hydrochloride, riboflavin, pyridoxine hydrochloride, folic acid, potassium iodide, phylloquinone, biotin, sodium selenate, vitamin D3, cyanocobalamin. * of arachidonic acid (ARA). ** of docosahexaenoic acid (DHA). CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Coconut oil, other soy components. Similac Alimentum contains a pre-digested protein (casein hydrolysate). This hypoallergenic formula is specifically designed for infants and children who cannot tolerate milk- or soy-based formulas. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. SIMILAC ALIMENTUM OMEGA-3 AND OMEGA-6 Hypoallergenic, extensively hydrolyzed formula For infants 0+ months of age

86 NOTES:

87 TODDLERS AND CHILDREN IN THIS SECTION PediaSure Complete Grow & Gain PediaSure PediaSure Fibre PediaSure Plus (with fibre) PediaSure Peptide 1 Cal Toddlers and Children

88 Toddlers and Children TODDLERS AND CHILDREN

89 LEARN ABOUT scfos WHAT ARE scfos? Short-chain fructooligosaccharides (scfos) are nondigestible carbohydrates that are naturally found in common foods such as bananas, asparagus and onions. 1,2 scfos are recognized as a source of dietary fibre by Health Canada 3 and are defined as prebiotics by the scientific community because they stimulate the growth of beneficial intestinal bacteria. 1 scfos AND THE GASTROINTESTINAL TRACT scfos are not digested in the small intestine, remaining intact until they reach the colon, where they are fermented by beneficial bacteria (such as bifidobacteria and lactobacilli) to short-chain fatty acids (SCFAs). 1,2,4 WHAT BENEFITS DO scfos PROVIDE? scfos can help your patients meet their daily fibre requirements. 3 SCFAs are the preferred energy source for cells in the colon. 4 Abbott Nutrition pediatric products containing scfos: PediaSure Plus (with fibre) PediaSure Peptide 1 Cal PediaSure Complete Grow & Gain Abbott Nutrition adult products containing scfos: Ensure Enlive Ensure scfos Fibre Ensure Pudding Glucerna Bar Glucerna Nutritional Drink Jevity 1.2 Cal Jevity 1.5 Cal Nepro Suplena TwoCal HN REFERENCES: 1. Gibson GR et al. Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology 1995;108: Handbook of Prebiotics and Probiotics Ingredients: Health Benefits and Food Applications. Cho SS, Finocchiaro ET, eds. CRC Press, Taylor and Francis Group, Health Canada. List of Dietary Fibres Permitted for Use in Foods Available for Sale in Canada, September Topping DL, Clifton PM. Physiological Reviews 2001;81(3)

90 PEDIASURE COMPLETE GROW & GAIN Nutritional supplement For children 1 to 13 years of age New look. New name. Same trusted formulation! INDICATIONS FOR USE Complete, balanced nutrition to help support growth and development. PediaSure Complete Grow & Gain can be used with or between meals as part of a healthy diet. For children: Who are picky eaters. With feeding difficulties. Who require additional nutrients due to poor appetite or intake. With appetite suppression due to medication or treatment. Safety precautions: For oral feeding only not for tube feeding. Not for parenteral use. Not for children with galactosemia. For children under 1 year of age, consult a physician or qualified health care professional prior to using PediaSure Complete Grow & Gain. FEATURES AND BENEFITS Each bottle contains: 26 vitamins and minerals. 9.3 g protein to help build strong muscles and antibodies. DHA (4.3 mg/100 Cal), an omega-3 fatty acid that supports the normal physical development of the brain and eyes. 1 g of short-chain fructooligosaccharides (scfos). 5% of fat as medium-chain triglycerides, an easily digested and well-absorbed fat source. 1 Convenient, reclosable bottle. 3 delicious, kid-approved flavours. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 1.0 Protein (% of total energy) 16 Fat (% of total energy) 30 Carbohydrate (% of total energy) 54 Total Cal:g nitrogen ratio 160:1 Non-protein Cal:g nitrogen ratio 136:1 Water (g/l) 830 Osmolality (mosm/kg water) 600 Renal solute load (mosm/l) 350 Viscosity at room temperature/ Thin/thin chilled Minimum tube size for gravity/ N/A pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use PediaSure Complete 235-mL bottles 4 x 4/case Grow & Gain, Vanilla PediaSure Complete 235-mL bottles 4 x 4/case Grow & Gain, Chocolate PediaSure Complete 235-mL bottles 4 x 4/case Grow & Gain, Strawberry REFERENCE: 1. Duggan C, Watkins JB, and Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton

91 ENERGY Per 100 ml Per 235 ml ENERGY (Cal [kj]) 100 (419) 235 (984) PROTEIN (g) % of total energy 16 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) - - Carnitine (mg) - - Milk protein concentrate, soy protein isolate, whey protein concentrate FAT (g) % of total energy 30 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (mg) Linolenic acid (g) Docosahexaenoic acid (DHA) (mg) Omega-6:Omega-3 ratio 6.2:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) Soy oil, canola oil, MCT oil MCT oil (% of total fats) 5 CARBOHYDRATE (g) % of total energy 54 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) - - Sucrose, corn maltodextrin, scfos, cellulose gel Acesulfame-potassium (mg) - - Sucralose (mg) - - VITAMINS Vitamin A (RE [IU]) 100 (333) 235 (783) Vitamin D3 (mcg [IU]) 0.3 (10.2) 0.6 (24) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) - - MINERALS Sodium (mg [mmol]) 38 (1.65) 90 (3.91) Potassium (mg [mmol]) 191 (4.90) 450 (11.54) Chloride (mg [mmol]) 87 (2.45) 204 (5.75) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodide (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION Nutritional information for PediaSure Complete Grow & Gain, Vanilla, 235-mL bottle INGREDIENTS PediaSure Complete Grow & Gain, Vanilla: Water, sucrose, corn maltodextrin, milk protein concentrate, soy oil, soy protein isolate, whey protein concentrate, short-chain fructooligosaccharides (scfos), canola oil, natural and artificial flavours, cellulose gel, medium chain triglycerides, cellulose gum, carrageenan, soy lecithin, monoglycerides, *C. cohnii oil, **M. alpina oil, MINERALS (potassium citrate, magnesium phosphate, calcium phosphate, potassium chloride, potassium phosphate, sodium chloride, potassium hydroxide, zinc sulphate, ferrous sulphate, manganese sulphate, cupric sulphate, potassium iodide, sodium molybdate, chromium chloride, sodium selenate), VITAMINS (choline chloride, ascorbic acid, niacinamide, dl-α-tocopheryl acetate, calcium pantothenate, vitamin A palmitate, pyridoxine hydrochloride, thiamine chloride hydrochloride, riboflavin, folic acid, biotin, vitamin D3, cyanocobalamin). * of docosahexaenoic acid (DHA). ** of arachidonic acid (ARA). CONTAINS: Priority food allergens: Milk, soy. Ingredients associated with food intolerances and/ or sensitivities: Corn, coconut oil, natural and artificial flavour, lactose, and other soy components. Additional ingredient for chocolate: Dutch process cocoa. Additional ingredient for strawberry: Colour. Ingredients associated with food intolerances and/ or sensitivities: Colour. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. PEDIASURE COMPLETE GROW & GAIN Nutritional Supplement For children 1 to 13 years of age

92 PEDIASURE Sole-source nutrition For children 1 to 13 years of age INDICATIONS FOR USE For children: - Requiring short- or long-term tube feeding. - With increased nutrient needs. - With or at risk for malnutrition. - With failure to thrive. For oral or tube feeding use. Can be used as a supplement or as a sole source of nutrition. Safety precautions: Not for parenteral use. Not for children with galactosemia. For children under 1 year of age, consult a physician or qualified health care professional prior to using PediaSure. FEATURES AND BENEFITS Fortified with taurine and carnitine to help prevent deficiencies associated with long-term tube feeding % of fat as medium-chain triglycerides, an easily digested and well-absorbed fat source. 4 Provides 26 essential vitamins and minerals. 1.2:1 Ca:P ratio to help optimize calcium and phosphorus balance. 5 Isotonic to help with intolerance to hyperosmolar feedings. 5 3 delicious flavours to help prevent flavour fatigue and improve compliance. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 1.0 Protein (% of total energy) 12.0 Fat (% of total energy) 44.2 Carbohydrate (% of total energy) 43.8 Total Cal:g nitrogen ratio 208:1 Non-protein Cal:g nitrogen ratio 183:1 Water (g/l) 854 Osmolality (mosm/kg water) 310 Renal solute load (mosm/l) 275 Viscosity at room temperature/ Thin/thin chilled Minimum tube size for gravity/ 10/8 pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use PediaSure, Vanilla 235-mL cans 12/case PediaSure, Strawberry 235-mL cans 12/case PediaSure, Chocolate 235-mL cans 12/case REFERENCES: 1. Feller AG et al. Subnormal concentrations of serum selenium and plasma carnitine in chronically tube-fed patients. Am J Clin Nutr 1987;45: Fischer MH et al. Improved selenium carnitine and taurine status in an enterally fed population. JPEN 1990;14: Bourdet B et al. Plasma Free Carnitine Depletion in Polytrauma Patients. J Nutr Health Aging 2010;14(3): Duggan C, Watkins JB and Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton PediaSure Product Monograph, October

93 ENERGY Per 100 ml Per 235 ml ENERGY (Cal [kj]) 100 (419) 235 (984) PROTEIN (g) % of total energy 12.0 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Sodium caseinate, whey protein concentrate FAT (g) % of total energy 44.2 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) - - Linolenic acid (g) Docosahexaenoic acid (DHA) (g) - - Omega-6:Omega-3 ratio 11:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic safflower oil, soy oil, MCT oil MCT oil (% of total fats) 19.5 CARBOHYDRATE (g) % of total energy 43.8 Total dietary fibre (g) - - Short-chain fructooligosaccharides - - (scfos) (g) Galactooligosaccharides (GOS) (g) - - Corn maltodextrin, sucrose Acesulfame-potassium (mg) - - Sucralose (mg) - - VITAMINS Vitamin A (RE [IU]) 78 (259) 182 (608) Vitamin D3 (mcg [IU]) 0.8 (32.0) 1.9 (75.2) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) - - MINERALS Sodium (mg [mmol]) 37 (1.61) 87 (3.78) Potassium (mg [mmol]) 130 (3.33) 306 (7.85) Chloride (mg [mmol]) 101 (2.85) 238 (6.71) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION Nutritional information for PediaSure, Vanilla, 235-mL can INGREDIENTS PediaSure, Vanilla: Water, maltodextrin, sucrose, sodium caseinate, high oleic safflower oil, soy oil, medium chain triglycerides (modified coconut oil and/or palm kernel oil), whey protein concentrate, calcium phosphate, natural and artificial flavour, potassium citrate, magnesium chloride, potassium phosphate, potassium chloride, monoglycerides, soy lecithin, choline chloride, carrageenan, ascorbic acid, potassium hydroxide, taurine, dl-α-tocopheryl acetate, ferrous sulphate, zinc sulphate, niacinamide, L-carnitine, d-calcium pantothenate, manganese sulphate, citric acid, thiamine hydrochloride, pyridoxine hydrochloride, riboflavin, cupric sulphate, vitamin A palmitate, folic acid, biotin, potassium iodide, sodium molybdate, sodium selenite, phylloquinone, cyanocobalamin, vitamin D3. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/ or sensitivities: Corn, coconut oil, citric acid, natural and artificial flavour, lactose, other soy components. Additional ingredient for chocolate: Dutch process cocoa. Additional ingredient for strawberry: Colour. Ingredients associated with food intolerances and/ or sensitivities: Colour. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. PEDIASURE Sole-source nutrition For children 1 to 13 years of age

94 PEDIASURE FIBRE Sole-source nutrition For children 1 to 13 years of age INDICATIONS FOR USE For children: - who may benefit from dietary fibre; - requiring short- or long-term tube feeding; - with increased nutrient needs; - with or at risk for malnutrition; - with failure to thrive. For oral or tube feeding use. Can be used as a supplement or as a sole source of nutrition. Safety precautions: Not for parenteral use. Not for children with galactosemia. For children under 1 year of age, consult a physician or qualified health care professional prior to using PediaSure Fibre. FEATURES AND BENEFITS Provides 1.1 g of dietary fibre per 235 ml. Fortified with taurine and carnitine to help prevent deficiencies associated with long-term tube feeding % of fat as medium-chain triglycerides, an easily digested and well-absorbed fat source :1 Ca:P ratio to help optimize calcium and phosphorus balance. 5 TECHNICAL DATA Ready to use Caloric density (Cal/mL) 1.0 Protein (% of total energy) 12.2 Fat (% of total energy) 44.8 Carbohydrate (% of total energy) 43.0 Total Cal:g nitrogen ratio 206:1 Non-protein Cal:g nitrogen ratio 181:1 Water (g/l) 854 Osmolality (mosm/kg water) 345 Renal solute load (mosm/l) 275 Viscosity at room temperature/ Thin/thin chilled Minimum tube size for gravity/ 10/8 pump feeding (Fr) Low residue Gluten-free Kosher Halal No AVAILABILITY Ready to use PediasSure Fibre, Vanilla 235-mL cans 12/case REFERENCES: 1. Feller AG et al. Subnormal concentrations of serum selenium and plasma carnitine in chronically tube-fed patients. Am J Clin Nutr 1987;45: Fischer MH et al. Improved selenium carnitine and taurine status in an enterally fed population. JPEN 1990;14: Bourdet B et al. Plasma Free Carnitine Depletion in Polytrauma Patients. J Nutr Health Aging 2010;14(3): Duggan C, Watkins JB and Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton PediaSure Product Monograph, October

95 ENERGY Per 100 ml Per 235 ml ENERGY (Cal [kj]) 100 (419) 235 (984) PROTEIN (g) % of total energy 12.2 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Sodium caseinate, whey protein concentrate FAT (g) % of total energy 44.8 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) - - Linolenic acid (g) Docosahexaenoic acid (DHA) (g) - - Omega-6:Omega-3 ratio 11:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic safflower oil, soy oil, MCT oil MCT oil (% of total fats) 19.5 CARBOHYDRATE (g) % of total energy 43.0 Total dietary fibre (g) Short-chain fructooligosaccharides - - (scfos) (g) Galactooligosaccharides (GOS) (g) - - Corn maltodextrin, sucrose, soy polysaccharide Acesulfame-potassium (mg) - - Sucralose (mg) - - VITAMINS Vitamin A (RE [IU]) 78 (259) 182 (608) Vitamin D3 (mcg [IU]) 0.80 (32.0) 1.88 (75.2) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) - - MINERALS Sodium (mg [mmol]) 37 (1.61) 87 (3.78) Potassium (mg [mmol]) 130 (3.33) 306 (7.85) Chloride (mg [mmol]) 101 (2.85) 238 (6.71) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION INGREDIENTS PediaSure Fibre, Vanilla: Water, corn maltodextrin, sucrose, sodium caseinate, high oleic safflower oil, soy oil, medium chain triglycerides (modified coconut oil and/or palm kernel oil), whey protein concentrate, soy polysaccharide, calcium phosphate, natural and artificial flavour, potassium citrate, magnesium chloride, potassium phosphate, potassium chloride, monoglycerides, soy lecithin, choline chloride, carrageenan, ascorbic acid, potassium hydroxide, taurine, dl-α-tocopheryl acetate, ferrous sulphate, zinc sulphate, niacinamide, L-carnitine, d-calcium pantothenate, manganese sulphate, citric acid, thiamine hydrochloride, pyridoxine hydrochloride, riboflavin, cupric sulphate, vitamin A palmitate, folic acid, biotin, potassium iodide, sodium molybdate, sodium selenite, phylloquinone, cyanocobalamin, vitamin D3. May contain sodium citrate. CONTAINS: Priority food allergens: Milk, soy. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, citric acid, natural and artificial flavour, lactose, other soy components. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. PEDIASURE FIBRE Sole-source nutrition For children 1 to 13 years of age

96 PEDIASURE PLUS (WITH FIBRE) Sole-source nutrition For children 1 to 13 years of age INDICATIONS FOR USE For children: - With fluid restrictions or volume sensitivity. - Who may benefit from dietary fibre. - Requiring short- or long-term tube feeding. - With increased nutrient needs. - With or at risk for malnutrition. - With failure to thrive. For oral or tube feeding use. Can be used as a supplement or as a sole source of nutrition. Safety precautions: Not for parenteral use. Not for children with galactosemia. For children under 1 year of age, consult a physician or qualified health care professional prior to using Pediasure Plus (with fibre). FEATURES AND BENEFITS Increased nutrient density provides more calories in less volume: 118 more calories per serving than PediaSure. Provides 1.76 g of dietary fibre per 235-mL. Contains 0.82 g of short-chain fructooligosaccharides (scfos) per 235-mL serving. Fortified with taurine and carnitine to help prevent deficiencies associated with long-term tube feeding % of fat as medium-chain triglycerides, an easily digested and well-absorbed fat source. 4 TECHNICAL DATA Ready to use Caloric density (Cal/mL) 1.5 Protein (% of total energy) 11.0 Fat (% of total energy) 43.3 Carbohydrate (% of total energy) 45.7 Total Cal:g nitrogen ratio 232:1 Non-protein Cal:g nitrogen ratio 207:1 Water (g/l) 778 Osmolality (mosm/kg water) 387 Renal solute load (mosm/l) 348 Viscosity at room temperature/ Thin/thin chilled Minimum tube size for gravity/ 10/8 pump feeding (Fr) Low residue No Gluten-free No Kosher Halal AVAILABILITY Ready to use PediaSure Plus 235-mL cans 12/case (with fibre), Vanilla REFERENCES: 1. Feller AG et al. Subnormal concentrations of serum selenium and plasma carnitine in chronically tube-fed patients. Am J Clin Nutr 1987;45: Fischer MH et al. Improved selenium carnitine and taurine status in an enterally fed population. JPEN 1990;14: Bourdet B et al. Plasma Free Carnitine Depletion in Polytrauma Patients. J Nutr Health Aging 2010;14(3): Duggan C, Watkins JB and Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton

97 ENERGY Per 100 ml Per 235 ml ENERGY (Cal [kj]) 150 (628) 353 (1476) PROTEIN (g) % of total energy 11.0 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Sodium and calcium caseinates, whey protein concentrate FAT (g) % of total energy 43.3 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) - - Linolenic acid (g) Docosahexaenoic acid (DHA) (g) - - Omega-6:Omega-3 ratio 11:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) High oleic safflower oil, soy oil, MCT oil MCT oil (% of total fats) 19.6 CARBOHYDRATE (g) % of total energy 45.7 Total dietary fibre (g) charides (scfos) (g) Short-chain fructooligosac Galactooligosaccharides (GOS) (g) - - Corn maltodextrin, sucrose, scfos, modified oat hulls, soy cotyledon fibre, gum arabic, carboxymethylcellulose Acesulfame-potassium (mg) - - Sucralose (mg) - - VITAMINS Vitamin A (RE [IU]) 99 (330) 233 (776) Vitamin D3 (mcg [IU]) 1.13 (45) 2.65 (106) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) MINERALS Sodium (mg [mmol]) 65 (2.83) 153 (6.65) Potassium (mg [mmol]) 180 (4.62) 423 (10.85) Chloride (mg [mmol]) 122 (3.44) 287 (8.10) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) NUTRITIONAL INFORMATION INGREDIENTS PediaSure Plus (with fibre), Vanilla: Water, corn maltodextrin, high oleic safflower oil, sodium caseinate, soy oil, sucrose, medium chain trigly cerides (modified coconut oil and/or palm kernel oil), calcium caseinate, whey protein concentrate, potassium citrate, short-chain fructooligosaccharides, modified oat hulls, soy cotyledon fibre, natural and artificial flavour, calcium phosphate, magnesium chloride, gum arabic, potassium phosphate, monoglycerides, soy lecithin, sodium carboxymethyl cellulose, sodium citrate, choline chloride, sodium chloride, ascorbic acid, taurine, m-inositol, potassium chloride, ferrous sulphate, zinc sulphate, niacinamide, L-carnitine, dl-α-tocopheryl acetate, d-calcium pantothenate, cupric sulphate, citric acid, thiamine hydrochloride, pyridoxine hydrochloride, riboflavin, manganese sulphate, vitamin A palmitate, folic acid, biotin, potassium iodide, chromium chloride, sodium molybdate, phylloquinone, sodium selenate, vitamin D3, cyanocobalamin. CONTAINS: Priority food allergens: Milk, soy. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, gluten, natural and artificial flavour, lactose, other soy components. Products containing oat fibre cannot be considered gluten-free. Fructooligosaccharides (FOS) have been listed as an accepted source of dietary fibre by Health Canada in April Labels will be revised accordingly as part of Abbott Nutrition s ongoing label review. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. PEDIASURE PLUS (WITH FIBRE) Sole-source nutrition For children 1 to 13 years of age

98 PEDIASURE PEPTIDE 1 CAL Specialized peptide-based liquid formula For children 1 to 13 years of age Great-tasting product INDICATIONS FOR USE PediaSure Peptide 1 Cal is a unique ready-to-drink peptide-based liquid formula for children with impaired gastro-intestinal function. It offers flexibility to meet nutritional needs both orally or as a tube feeding. For children with: - GI disease: pancreatitis (acute or chronic) or pancreatic insufficiency; cystic fibrosis; Crohn s disease, ulcerative colitis or short bowel syndrome; HIV/AIDS-associated enteropathy; celiac disease; gastritis, duodenitis, enterocolitis; dumping syndrome; GI fistulas; - GI intolerance symptoms: gas, bloating, diarrhea and abdominal distention; - acute GI dysfunction: critical illness; trauma; burns; sepsis; post-transplant surgery; post-gastric surgery; - impaired GI function: abdominal and other surgeries; certain cancer treatments; generalized malabsorption; general intolerance to polymeric feedings; cerebral palsy. Can be used: - as a supplement or as a sole source of nutrition; for early enteral feeding; for dual feeding (parenteral + enteral); for transition from total parenteral nutrition (TPN); for trophic feeding. For oral or tube feeding use. Safety precautions: Not for parenteral use. Not for children with galactosemia. Health care professional clinical judgment is required for use in children under 1 year of age. FEATURES AND BENEFITS Nutrient blend designed to help support tolerance and absorption: - 100% hydrolyzed protein; - 50% of fat as medium-chain triglycerides (MCT), an easily digested and well-absorbed fat source. 1 Contains 1 g of short-chain fructooligosaccharides (scfos) fibre per 237-mL serving. 28 vitamins and minerals. Convenient, reclosable bottle. TECHNICAL DATA Ready to use Caloric density (Cal/mL) 1.0 Protein (% of total energy) 12.0 Fat (% of total energy) 35.0 Carbohydrate (% of total energy) 53.0 Total Cal:g nitrogen ratio 208:1 Non-protein Cal:g nitrogen ratio 183:1 Water (g/l) 844 Osmolality (mosm/kg water) 390 Renal solute load (mosm/l) 265 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ 10/8 pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use PediaSure Peptide 1 Cal, Vanilla 237-mL bottles 24/case REFERENCE: 1. Duggan C, Watkins JB and Walker WA. Nutrition in Pediatrics: Standard and Specialized Enteral Formulas. BC Decker Inc. Hamilton

99 ENERGY Per 100 ml Per 237 ml ENERGY (Cal [kj]) 100 (418) 237 (992) PROTEIN (g) 3 7 % of total energy 12.0 Arginine (mg) Cystine (mg) Histidine (mg) Isoleucine (mg) Leucine (mg) Lysine (mg) Methionine (mg) Phenylalanine (mg) Tryptophan (mg) Threonine (mg) Valine (mg) Taurine (mg) Carnitine (mg) Whey protein hydrolysate, hydrolyzed sodium caseinate FAT (g) 4 10 % of total energy 35.0 Polyunsaturated fatty acids (g) Linoleic acid (g) Arachidonic acid (ARA) (g) - - Linolenic acid (g) Docosahexaenoic acid (DHA) (g) - - Omega 6:Omega 3 ratio 2.7:1 Monounsaturated fatty acids (g) Saturated fatty acids (g) Cholesterol (mg) Structured lipid (interesterified canola oil and mediumchain triglycerides) MCT oil (% of total fats) 50 CARBOHYDRATE (g) % of total energy 53.0 Total dietary fibre (g) Short-chain fructooligosaccharides (scfos) (g) Galactooligosaccharides (GOS) (g) - - Corn maltodextrin, sucrose Acesulfame-potassium (mg) - - Sucralose (mg) 6 14 VITAMINS Vitamin A (RE [IU]) 75 (250) (592) Vitamin D3 (mcg [IU]) 1.33 (53.0) 3.13 (125) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) - - MINERALS Sodium (mg [mmol]) 70 (3.04) 170 (7.39) Potassium (mg [mmol]) 135 (3.46) 320 (8.21) Chloride (mg [mmol]) 101 (2.85) 240 (6.77) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) Molybdenum (mg) INGREDIENTS PediaSure Peptide 1 Cal, Vanilla: Water, corn maltodextrin, sucrose, whey protein hydrolysate, structured lipid (interesterified canola oil and medium chain triglycerides*), hydrolyzed sodium caseinate, MINERALS (calcium phosphate, potassium citrate, magnesium phosphate, potassium chloride, magnesium chloride, sodium citrate, ferrous sulphate, zinc sulphate, manganese sulphate, cupric sulphate, chromium chloride, potassium iodide, sodium selenate, sodium molybdate), medium chain triglycerides*, canola oil, short-chain fructooligosaccharides, natural and artificial flavours, VITAMINS (ascorbic acid, choline chloride, m-inositol, dl-α-tocopheryl acetate, d-calcium pantothenate, niacinamide, thiamine chloride hydrochloride, pyridoxine hydrochloride, riboflavin, vitamin A palmitate, folic acid, biotin, phylloquinone, cyanocobalamin, vitamin D3), cellulose gel, soy lecithin, carrageenan, sucralose, cellulose gum, taurine, L-carnitine. * modified coconut oil and/or palm kernel oil. CONTAINS: Priority food allergens: Milk. Ingredients associated with food intolerances and/or sensitivities: Corn, coconut oil, natural and artificial flavours, lactose, and other soy components. NUTRITIONAL INFORMATION Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. PEDIASURE PEPTIDE 1 CAL Specialized peptide-based liquid formula For children 1 to 13 years of age

100 NOTES:

101 SPECIALTY PRODUCTS Specialty Products IN THIS SECTION Pedialyte and Pedialyte Freezer Pops Pedialyte (HFS) Similac 5% Glucose Water (HFS) Similac Sterilized Water (HFS) RCF

102 Specialty Products SPECIALTY PRODUCTS

103 DOSAGE CHART (PEDIALYTE ) This chart suggests the daily dosage requirements of Pedialyte in millilitres. The volume necessary is based on the child s weight ( ml/kg 1 or approximately Freezer Pops/kg). Pedialyte should be offered in small frequent sips every 15 minutes, increasing serving size as tolerated. Total daily intake should be adjusted to meet individual needs, based on thirst and response to therapy. The suggested intakes for maintenance are based on water requirements for ordinary energy expenditure. 2 Dosage chart does not apply to infants younger than 1 week of age. For children older than 4 years of age, maintenance intakes may exceed 2 litres (32 or more Freezer Pops) daily. If there is vomiting or fever, or if diarrhea continues beyond 24 hours, consult the child s physician. Body Weight Pedialyte ml/day for maintenance 3 kg (6.6 lb) kg (8.8 lb) kg (11.0 lb) kg (13.2 lb) kg (15.4 lb) kg (17.6 lb) kg (19.8 lb) kg (22.0 lb) kg (24.2 lb) kg (26.4 lb) kg (28.6 lb) kg (30.8 lb) kg (33.0 lb) kg (35.2 lb) kg (37.4 lb) kg (39.6 lb) kg (41.8 lb) kg (44.0 lb) NOTE: 4 Freezer Pops = 250 ml = 1 cup. Fluid intake is total fluid requirement from oral electrolyte solution, formula, or other fluids, but does not take into account ongoing stool losses. Fluid loss in the stools should be replaced by consumption of an extra amount of Pedialyte equal to stool losses, in addition to the fluid maintenance requirement in this dosage chart. Pedialyte products are to be used with other appropriate fluids to help prevent dehydration. REFERENCES: 1. Leung A, Prince T. Canadian Paediatric Society Nutrition and Gastroenterology Committee Paediatr Child Health Oral rehydration therapy and early refeeding in the management of childhood gastroenteritis 2006;11(8): Extrapolated from Barness LA, Curran JS: Nutrition, in Nelson WE (sr ed), Behrman RE, Kliegman RM, Arvin AM (eds): Nelson Textbook of Pediatrics, ed 15. Philadelphia: WB Saunders Co, 1996, pp

104 PEDIALYTE Oral electrolyte maintenance solution New look. Same formulation! INDICATIONS FOR USE Pedialyte is specially formulated to help prevent dehydration by restoring vital nutrients lost during diarrhea and vomiting in infants, children and adults. It can be used for maintenance of water and electrolytes following corrective parenteral therapy. Safety precautions: Not for parenteral use. For children under 2 years of age, consult a physician or qualified health care professional prior to using Pedialyte as infants and young children are at greater risk of dehydration. FEATURES AND BENEFITS #1 pediatrician recommended brand. Great for children and adults. Designed to prevent dehydration more effectively than common household beverages. Provides glucose to promote sodium and water absorption. Contains the balance of sodium and sugar recommended by experts 1,2 to help prevent dehydration due to diarrhea and vomiting. Low osmolality. Unflavoured liquid available for infants. Great-tasting flavours to enhance compliance mL reclosable plastic bottles for easy measuring and pouring. Freezer Pops (62.5 ml Pedialyte per sleeve) available in 4 flavours. Ready to use No mixing or dilution necessary. TECHNICAL DATA Ready to use Ready to use Unflavoured Flavoured (including Freezer Pops) Caloric density (Cal/mL) Protein (% of total energy) N/A N/A Fat (% of total energy) N/A N/A Carbohydrate (% of total energy) Total Cal:g nitrogen ratio N/A N/A Non-protein Cal:g nitrogen ratio N/A N/A Water (g/l) Osmolality (mosm/kg water) Renal solute load (mosm/l) Viscosity at room temperature/ - - chilled Minimum tube size for gravity/ pump feeding (Fr) N/A N/A Low residue Gluten-free Kosher Halal Pedialyte Grape: Pedialyte Fruit, Freezer Pops (all flavours): No AVAILABILITY Ready to use 0E Pedialyte Unflavoured 1000-mL reclosable 8/case plastic bottles Pedialyte Grape 1000-mL reclosable 8/case plastic bottles Pedialyte Fruit 1000-mL reclosable 8/case plastic bottles Pedialyte Freezer 62.5-mL 8 x 16/case Pops Variety Pack sleeves Grape, Cherry, Orange and Blue Raspberry. REFERENCES: 1. World Health Organization. Oral Rehydration Salts: Production of the new ORS Leung A, Prince T. Oral Rehydration therapy and early refeeding in the management of childhood gastroenteritis. Canadian Paediatric Society Nutrition and Gastroenterology Committee. Paediatr Child Health. 2006;11(8):

105 ENERGY Per 62.5 ml Freezer Pop Per 100 ml Per 1000 ml ENERGY (Cal [kj]) 6.3 (26.4) 10 (42) 100 (420) CARBOHYDRATE (g) % of total energy Dextrose Dextrose Dextrose ELECTROLYTES Sodium (mg [mmol]) 64.8 (2.8) (4.5) (45) Potassium (mg [mmol]) 48.8 (1.3) 78.0 (2.0) 780 (20) Chloride (mg [mmol]) 77.8 (2.2) (3.5) (35) Citrate (mg [mmol]) (0.6) (1.0) 1890 (10) FLAVOURED ONLY Acesulfame-potassium (mg) Sucralose (mg) Nutritional information for Pedialyte, 1000 ml and Pedialyte Freezer Pops, 62.5 ml INGREDIENTS Pedialyte, Unflavoured: MEDICINAL INGREDIENTS: Sodium (sodium chloride, sodium citrate), potassium (potassium citrate), chloride (sodium chloride). NON-MEDICINAL INGREDIENTS: Water, dextrose, citric acid. CONTAINS: Ingredient associated with food intolerances and/or sensitivities: Citric acid. NUTRITIONAL INFORMATION Pedialyte, Grape: MEDICINAL INGREDIENTS: Sodium (sodium chloride, sodium citrate), potassium (potassium citrate), chloride (sodium chloride). NON-MEDICINAL INGREDIENTS: Water, dextrose, citric acid, artificial grape flavour, sucralose, acesulfame potassium, FD&C Red No. 40 and FD&C Blue No. 1. CONTAINS: Ingredients associated with food intolerances and/or sensitivities: Citric acid, colours, natural and artificial flavours. Pedialyte, Fruit: MEDICINAL INGREDIENTS: Sodium (sodium chloride, sodium citrate), potassium (potassium citrate), chloride (sodium chloride). NON-MEDICINAL INGREDIENTS: Water, dextrose, citric acid, natural and artificial fruit flavour, sucralose, acesulfame potassium, FD&C yellow No. 6. CONTAINS: Ingredients associated with food intolerances and/or sensitivities: Citric acid, colours, natural and artificial flavours. Pedialyte Freezer Pops, Grape, Cherry, Orange and Blue Raspberry: MEDICINAL INGREDIENTS: Sodium (sodium chloride, sodium citrate), potassium (potassium citrate), chloride (sodium chloride). NON-MEDICINAL INGREDIENTS: Water, dextrose, citric acid, sodium carboxymethylcellulose, potassium sorbate, sodium benzoate, sucralose and acesulfame potassium. CONTAINS: Ingredients associated with food intolerances and/or sensitivities: Citric acid, colours, natural and artificial flavours. Additional ingredients for Grape: Natural and artificial grape flavour, FD&C Red No. 40 and FD&C Blue No.1. Additional ingredients for Cherry: Natural and artificial cherry flavour and FD&C Red No. 40. Additional ingredients for Orange: Natural and artificial orange flavour, FD&C Yellow No. 6 and FD&C Red No. 40. Additional ingredients for Blue Raspberry: Natural and artificial blue raspberry flavour and FD&C Blue No.1. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. PEDIALYTE Oral electrolyte maintenance solution

106 PEDIALYTE Oral electrolyte maintenance solution INDICATIONS FOR USE For infants and children at risk for dehydration. For infants and children with diarrhea and/or vomiting. - To help prevent dehydration. - To help replace fluids and electrolytes lost during diarrhea and vomiting. - For maintenance of water and electrolytes following corrective parenteral therapy. For oral or tube feeding use. Safety precautions: Not for parenteral use. For children under 2 years of age, consult a physician or qualified health care professional prior to using Pedialyte as infants and young children are at greater risk of dehydration. FEATURES AND BENEFITS Designed to prevent dehydration more effectively than common household beverages. Provides glucose to promote sodium and water absorption. Balanced electrolytes to replace the electrolytes lost during diarrhea and to help prevent dehydration. Unflavoured liquid available for infants. Ready to use no mixing or dilution necessary. TECHNICAL DATA Ready to use Unflavoured Caloric density (Cal/mL) 0.10 Protein (% of total energy) 0 Fat (% of total energy) 0 Carbohydrate (% of total energy) 100 Total Cal:g nitrogen ratio N/A Non-protein Cal:g nitrogen ratio N/A Water (g/l) 978 Osmolality (mosm/kg water) 250 Renal solute load (mosm/l) 100 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ N/A pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Pedialyte Unflavoured 59-mL plastic 48/case bottles 106

107 ENERGY Per 59 ml Per 100 ml ENERGY (Cal [kj]) 5.9 (24.7) 10 (42) CARBOHYDRATE (g) % of total energy Dextrose Dextrose ELECTROLYTES Sodium (mg [mmol]) (4.5) Potassium (mg [mmol]) 46.0 (1.2) 78.0 (2.0) Chloride (mg [mmol]) 73.4 (2.1) (3.5) Citrate (mg [mmol]) (0.6) (1.0) INGREDIENTS Pedialyte, Unflavoured: MEDICINAL INGREDIENTS: Sodium (sodium chloride, sodium citrate), potassium (potassium citrate), chloride (sodium chloride). NON-MEDICINAL INGREDIENTS: Water, dextrose, citric acid. CONTAINS: Ingredients associated with food intolerances and/or sensitivities: Citric acid. NUTRITIONAL INFORMATION Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. PEDIALYTE Oral electrolyte maintenance solution

108 SIMILAC 5% GLUCOSE WATER INDICATIONS FOR USE For initial or supplemental feeding. For oral feeding only not for tube feeding. Safety precaution: Use under medical supervision. FEATURES AND BENEFITS Ready to use No mixing or dilution necessary. TECHNICAL DATA Bottle Caloric density (Cal/mL) 0.2 Protein (% of total energy) 0 Fat (% of total energy) 0 Carbohydrate (% of total energy) 100 Total Cal:g nitrogen ratio N/A Non-protein Cal:g nitrogen ratio N/A Water (%) 96.6 Osmolality (mosm/kg water) N/A Renal solute load (mosm/l) N/A Viscosity at room temperature/ - chilled Minimum tube size for gravity/ N/A pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Similac 5% Glucose Water 59-mL plastic 48/case bottles ENERGY Per 100 ml Per 100 Cal Per 1000 ml Per 59 ml ENERGY (Cal [kj]) 20 (85) 100 (418) 200 (837) 24 (100) CARBOHYDRATE (g) % of total energy 100 Dextrose INGREDIENTS Similac 5% Glucose Water, Ready to use: Water and anhydrous dextrose. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. 108

109 SIMILAC STERILIZED WATER INDICATIONS FOR USE For initial or supplemental feeding. For oral feeding only not for tube feeding. Safety precaution: Use under medical supervision. FEATURES AND BENEFITS Ready to use No mixing or dilution necessary. TECHNICAL DATA Caloric density (Cal/mL) Protein (% of total energy) Fat (% of total energy) Carbohydrate (% of total energy) Total Cal:g nitrogen ratio Non-protein Cal:g nitrogen ratio Bottle N/A N/A N/A N/A N/A N/A Water (%) 100 Osmolality (mosm/kg water) N/A Renal solute load (mosm/l) N/A Viscosity at room temperature/ - chilled Minimum tube size for gravity/ N/A pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Ready to use Similac Sterilized Water 59-mL plastic 48/case bottles Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. 109

110 RCF No added carbohydrate soy-based iron-fortified formula INDICATIONS FOR USE For use in the dietary management of: - Patients unable to tolerate the type or amount of carbohydrate in milk or conventional infant formulas; - Patients with seizure disorders requiring a ketogenic diet. Safety precautions: Not for parenteral use. Use under medical supervision. FEATURES AND BENEFITS Formulated to allow the health care professional to prescribe the type and amount of carbohydrate that can be tolerated with the assurance that other nutrient needs will be met. Soy protein isolate to avoid symptoms of cow s milk-protein allergy or sensitivity. L-carnitine (3 mg/100 ml) and taurine (12 mg/100 ml). TECHNICAL DATA Concentrated Liquid Caloric density (Cal/mL) 0.81 Protein (% of total energy) 20 Fat (% of total energy) 80 Carbohydrate (% of total energy) 0 Total Cal:g nitrogen ratio 127:1 Non-protein Cal:g nitrogen ratio 101:1 Water (g/l) 880 Osmolality (mosm/kg water) 90 Renal solute load (mosm/l) 34.8 Viscosity at room temperature/ - chilled Minimum tube size for gravity/ N/A pump feeding (Fr) Low residue Gluten-free Kosher Halal AVAILABILITY Concentrated Liquid RCF 384-mL cans 12/case PREPARATION For 20 Cal/30 ml formula: Use the type and amount of carbohydrate specified by a health care professional (see table below). 1. Dissolve carbohydrate in 355 ml of water, cover and bring to a boil. Keep covered; allow to cool. 2. Rinse can lid and shake very well. Open with clean punch-type opener. 3. Add RCF to cooled carbohydrate solution prepared in step 1. Mix and pour into bottles (or cup). 4. Once feeding begins, use within 1 hour or discard. For 54 g of carbohydrate, add one of the following: Table sugar (sucrose) Fructose powder Dextrose powder (hydrous) 60 ml (4 level Tbsp) 60 ml (4 level Tbsp) 90 ml (6 level Tbsp) 110

111 ENERGY Per 100 ml (concentrated liquid) Per 100 Cal (standard dilution) ENERGY (Cal [kj]) 81 (339) 100 (418) PROTEIN (g) Soy protein isolate, L-methionine FAT (g) Linoleic acid (g) Arachidonic acid (ARA) (g) - - Linolenic acid (g) - - Docosahexaenoic acid (DHA) (g) - - Omega-6:Omega-3 ratio 10.6:1 Cholesterol (mg) 0 0 High oleic safflower oil, soy oil, coconut oil MCT oil (% of total fats) 0.0 CARBOHYDRATE (g) Total dietary fibre (g) - - Short-chain fructooligosaccharides - - (scfos) (g) Galactooligosaccharides (GOS) (g) - - N/A Acesulfame-potassium (mg) - - Sucralose (mg) - - VITAMINS Vitamin A (RE [IU]) 122 (405) 90 (300) Vitamin D3 (mcg [IU]) 2.0 (81) 1.5 (60) Vitamin E (IU) Vitamin K1 (mg) Vitamin C (mg) 12 9 Thiamine (mg) Riboflavin (mg) Niacin (mg) Vitamin B6 (mg) Folic acid (mg) Vitamin B12 (mg) Pantothenic acid (mg) Biotin (mg) Choline (mg) Inositol (mg) Lutein (mg) - - MINERALS Sodium (mg [mmol]) 59.1 (2.6) 44 (1.9) Potassium (mg [mmol]) 146 (3.7) 108 (2.8) Chloride (mg [mmol]) 83 (2.3) 62 (1.8) Calcium (mg) Phosphorus (mg) Magnesium (mg) Iron (mg) Zinc (mg) Iodine (mg) Copper (mg) Manganese (mg) Selenium (mg) Chromium (mg) - - Molybdenum (mg) g of carbohydrate ml of water, mixed with 384 ml of RCF ; yields ~770 ml. NUTRITIONAL INFORMATION INGREDIENTS RCF, Concentrated liquid: Water (88%), soy protein isolate (5%), high oleic safflower oil (3%), soy oil (2%), coconut oil (2%); less than 1% of: calcium phosphate, potassium citrate, potassium chloride, magnesium chloride, monoglycerides, soy lecithin, carrageenan, salt, L-methionine, ascorbic acid, potassium hydroxide, choline chloride, taurine, m-inositol, ferrous sulfate, zinc sulfate, L-carnitine, niacinamide, d-α-tocopheryl acetate, calcium pantothenate, cupric sulfate, thiamine chloride hydrochloride, vitamin A palmitate, riboflavin, pyridoxine hydrochloride, folic acid, potassium iodide, phylloquinone, biotin, β-carotene, sodium selenate, vitamin D3 and cyanocobalamin. CONTAINS: Priority Food Allergens: Soy. Ingredients associated with food intolerances and/or sensitivities: Coconut oil and other soy components. Values listed are subject to change. Please refer to the product label or packaging for the most current ingredient, allergen and nutrient profile information. RCF No added carbohydrate soy-based iron-fortified infant formula

112 NOTES:

113 ACCESSORIES Accessories IN THIS SECTION Component Nipple System Plastic Bottle and Cap CustomFeed Bottle Volu-Feed Dispensing Cap

114 Accessories ACCESSORIES

115 COMPONENT NIPPLE SYSTEM Similac nipples are designed to be used with all Abbott Nutrition bottles, including: 120-mL and 59-mL Hospital Feeding System bottles. 240-mL plastic bottle. Volu-Feed nurser. Similac Infant Nipple and Ring # (250/case) Description Product Composition Latex-free Designed for use with term infants or for infants Nipple: polyisoprene with developed sucking strength. Ring: polyethylene Similac Orthodontic Nipple and Ring # (250/case) Description Product Composition Latex-free Designed for newborn infants (term or preterm). Opening faces infant s palate and orthodontic design stimulates oral exercise while feeding. Nipple: natural rubber latex Ring: polyethylene No Similac Premature Nipple and Ring # (250/case) Description Product Composition Latex-free Designed for preterm infants with less developed Nipple: polyisoprene sucking strength. Decreased bulb wall thickness Ring: polyethylene increases pliability and makes it easier to suckle. Similac Slow Flow Nipple and Ring # (250/case) Description Product Composition Latex-free Designed to support the underdeveloped suck-swallow-breathe coordination of lowbirth-weight or preterm infants. Provides a more infant-driven, controlled flow rate vs. faster-flow nipples for increased physiological stability and a more efficient sucking pattern. 1 Nipple: polyisoprene Ring: polyethylene FEATURES AND BENEFITS Easy to use. Flexibility to choose a nipple that matches each infant s sucking strength or need. Nipples and rings are individually pre-packaged and ready for use. Nipples and rings form a seal to prevent leakage during feeding. Disposable not for re-use. WARNINGS DO NOT use as a pacifier, as it presents a choking hazard. DO NOT re-use, as re-use can cause deterioration or separation of the rubber, presenting a choking hazard. Keep out of reach of children. REFERENCE: 1. Chang YJ et al. Effects of Single-Hole and Cross-Cut Nipple Units on Feeding Efficiency and Physiological Parameters in Premature Infants. J Nurs Res 2007;150(3):

116 PLASTIC BOTTLE AND CAP Plastic Bottle # (144/case) Description Product Composition Latex-free Volume: 240 ml. Designed for use as a nursing bottle. Polypropylene COMPATIBLE WITH All Similac Nipples. Plastic Bottle Cap. FEATURES AND BENEFITS Ready to use. Food grade quality. Unbreakable; safe for pediatric nurseries. Dishwasher-safe (top rack). Disposable. Plastic Bottle Cap # (250/case) Description Product Composition Latex-free Standard 40 mm finish. Polypropylene COMPATIBLE WITH 120-mL and 59-mL Hospital Feeding System bottles. 240-mL plastic bottle. Volu-Feed nurser. FEATURES AND BENEFITS Food grade quality. Dishwasher-safe (top rack). Can be prepared for use by placing in boiling water for 1 minute or washed in the top rack of a dishwasher. 116

117 CUSTOMFEED BOTTLE Breastmilk Storage Bottle with Cap NEW CustomFeed Bottle # (100/case) Description Product Composition Latex-free Volume: 60 ml. When accurate measurement of breast milk or formula is needed, particularly with preterm and low birth weight infants. Polypropylene COMPATIBLE WITH All Similac Nipples. Plastic Bottle Cap. Volu-Feed Dispensing Cap. Breast pumps that fit a standard sized bottle. FEATURES AND BENEFITS Ready to use 60 ml bottle - Packaged in an individual package with included cap - Accurate measurement - Graduated measurement (1 ml calibrations) - Nipple ready Freezable Disposable or reusable Dishwasher safe (top rack only) Manufactured without BPA Manufactured without Latex Manufactured without DEHP Volu-Feed Dispensing Cap # (250/case) Description Product Composition Latex-free Permits tube feeding using CustomFeed bottle by holding feeding tube in place. Polypropylene FEATURES AND BENEFITS Single use. Ready to use - individually packaged in a sealed, clean-peel blisterpack. Disposable. COMPATIBLE WITH CustomFeed Bottle. 117

118 NOTES:

119

120 To access an electronic version of this guide, scan the code with your smartphone or visit , option 1 Abbott Laboratories, Limited Printed in Canada DIR/269A08 - September