HLC PROBIOTICS PROFESSIONAL PRODUCT GUIDE NEW. NEW PRODUCTS INSIDE Research-driven, proprietary, human-sourced strains

Transcription

1 Where Nutritional Science Comes to Life. HLC PROBIOTICS PROFESSIONAL PRODUCT GUIDE NEW NEW PRODUCTS INSIDE Research-driven, proprietary, human-sourced strains

2 Where Nutritional Science Comes to Life. Pharmax is a leading-edge line of professional-grade nutraceuticals, helping rth American healthcare practitioners restore, rebuild and maintain patient health for over 15 years. A trusted Seroyal brand. 112 Technology Drive, Pittsburgh, PA TEL: FAX: sales@seroyal.com WEBSITE: ii These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, prevent any disease. The aim of this comprehensive product guide is to assist in building more effective and successful patient treatment strategies. The product guide is to be used as an adjunct to Seroyal Continuing Medical Education and is not intended to be utilized as a diagnostic tool nor replace any other required education. The remedies indicated in this product guide are potent medicines that can have profound therapeutic effects on patients. As with any intervention, the dosage may need to be adjusted for those with chronic conditions, very sensitive individuals and those taking multiple medications. Practitioners are solely responsible for the care and treatment provided to their own patients. The information provided by the speaker or speakers in the Seroyal Continuing Medical Education program together with any written material provided do not necessarily represent the views of Seroyal and are not intended as medical advice or an endorsement of any products. This information is for practitioner use only and is not meant to diagnose, treat, cure, prevent any disease or replace traditional treatment, and has not been evaluated by the FDA. Copyright 2015 Seroyal. All rights reserved. part of this information may be used or reproduced in any form or by any means, or stored in a database or retrieval system, or be distributed or replicated without express permission of Seroyal. Making copies of any part of this information for any purposes other than your own personal use is a violation of copyright law Version 6. Printed 02/2015.

3 TABLE OF CONTENTS Probiotics Market leader: Driving probiotic science and innovation for over 15 years...2 HLC Product Overview MAINTENANCE HLC Maintenance...4 HLC High Potency Capsules...4 HLC High Potency Powder...4 HLC Endure...5 HLC Multi Strain...5 HLC Intensive Capsules...5 HLC Intensive Powder...6 HLC Replenish Capsules...6 HLC Synbiotic Intensive...6 POST ANTIBIOTIC CARE HLC Antibiotic Care...7 IMMUNE HEALTH HLC Immunity + Pro...7 HLC Immunobiotics...7 HLC Probiotic Product Comparison Chart PREGNANCY AND CHILD SUPPORT HLC Maternity + Pro NEW HLC Maternity NEW HLC Baby B NEW HLC Baby F HLC Toddler + Pro HLC Child + Multi HLC Neonate HLC Child URINARY SUPPORT HLC Uritol Maintenance EXPORPHIN DEGRADING (in vitro) HLC MindLinx Capsules HLC MindLinx Powder COLON SUPPORT HLC Colon-izer PROBIOTICS 101 What are probiotics? There are billions of bacteria living in the intestinal tract often referred to as microflora. Probiotics are live friendly bacteria found in the microflora working to keep a healthy intestinal balance by replenishing and maintaining beneficial strains.* Maintaining this balance is critical for overall good health. Why supplement with probiotics? Beneficial bacteria may be reduced due to a variety of factors: Age Use of antibiotics or other medications Lifestyle Dietary changes or poor diet Stress Traveling Bacterial balance in the intestine promotes healthy gastrointestinal function.* Who should take probiotics? Daily probiotic supplementation is considered a necessary component of any healthy diet. It supports health in: Pre- and post-pregnancy Infants (1 year + ), children and adolescents Adults Seniors While probiotics may be added in foods such as yogurts and smoothies, direct probiotic supplementation provides the highest amount of beneficial live cultures. Probiotics should be a routine part of a daily lifestyle to help maintain optimal health conditions.* Clinical Trials The Swansea Baby Trial The Sheffield Trial All ages can benefit from probiotic supplementation. * These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. 1

4 MARKET LEADER DRIVING PROBIOTIC SCIENCE & INNOVATION FOR OVER 15 YEARS Pharmax Human Lactic Commensal (HLC) probiotics incorporate safe and effective strains reflecting the latest evidence-based research from human trials, and provide physicians and healthcare professionals a comprehensive range for individualized or condition-specific treatment. HUMAN-SOURCED STRAINS Natural ph and bile acid resistance: enteric coatings required Human-sourced microflora bacterial strains have high survival rates through various stomach ph ( ) thus maximizing intestinal tract exposure and eliminating the need for enteric coatings (capsule/tablet barriers that control digestive absorption). Naturally strong adherence: High ratio of intestinal tract carriage CFU (Colony Forming Unit) levels are important but effectiveness is best determined through intestinal tract carriage. Human-sourced microflora bacterial strains have a naturally strong adherence to epithelial cells thus ensuring high ratios of intestinal tract carriage. Clinically proven in randomized, double-blind, placebo-controlled human trials 25 billion CFU/day of: Clinically proven to: Reduce occasional GI symptoms* Maintain intestinal flora following antibiotic therapy* 10 billion CFU/day of: Lactobacillus salivarius (CUL-61) Lactobacillus paracasei (CUL-08) Clinically proven to: Promote skin health* Reduce incidence of skin sensitivity* Probiotic expertise: Global research and development drive category innovation A collaborative think-tank lead by Dr. Plummer has produced over 70 peer reviewed and PubMed listed publications. Nigel Plummer PhD: Global authority on probiotics This key probiotic contributor has worked at Pfizer in antibiotic R&D. A continued commitment to research has resulted in collaborations with research institutes and universities within the UK and Europe, developing an extensive knowledge specializing in probiotics, natural antimicrobials and fish oils. COMPREHENSIVE RANGE: CONVENIENT FORMATS, AGE-SPECIFIC AND CONDITION-SPECIFIC FORMULAS Available in an array of potencies (up to 150 billion CFU), formats (capsules, tablets, powders) and flavors to allow for flexibility in dosing and patient compliance. Therapies can be tailored for specific individualized treatments by age (pregnancy support, infants, and children to seniors) or condition-specific probiotics (exorphin degrading, femalespecific, GI, antibiotic support, urinary support). * 2 These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

5 GET AN EARLY START ON SKIN AND DIGESTIVE HEALTH A Trusted Seroyal Brand The NEW HLC Baby product family supports optimal microflora composition and gastrointestinal health using a combination of research-driven probiotic strains. * HLC Baby B (for breast fed babies) and HLC Baby F (for formula fed babies) each provide 10 billion CFU of proprietary human-sourced strains. Research indicates that probiotic supplementation from birth to six months helps support infant immune development, which is an important factor for skin health. HLC Baby B includes additional microflora support from added galactooligosaccharides (GOS), a prebiotic fiber similar to oligosaccharides naturally within breast milk. * HLC Baby F contains GOS and fructooligosaccharides (FOS) *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

6 MAINTENANCE HLC MAINTENANCE HLC HIGH POTENCY CAPSULES HLC HIGH POTENCY POWDER Low level maintenance probiotic 2.5 billion CFU per capsule Includes fructooligosaccharides (FOS) Convenient capsule format Increases patient compliance HLC Maintenance provides two strains of proprietary human-sourced Lactobacillus acidophilus, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis, to specifically assist in establishing and maintaining a healthy intestinal microflora.* Serving Size 1 Capsule/ Servings Per Container 60 or 120 HLC Consortium 2.5 billion viable cells Fructooligosaccharides (FOS) 100 mg Other ingredients: Cellulose, hypromellose, silica, vegetable magnesium stearate Adults and Children (6 years and older): One capsule taken 1-2 times daily with a meal, at least 2-3 hours before or after taking antibiotics, 60 vegetable capsules PB vegetable capsules PB Moderate level maintenance probiotic 10 billion CFU per capsule Includes fructooligosaccharides (FOS) Long-term maintenance Supporting a healthy normal digestive flora* Ideal for vegans Convenient vegetable capsule format HLC High Potency Capsules provides two strains of proprietary human-sourced Lactobacillus acidophilus, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis. Serving Size 1 Capsule/ Servings Per Container 60 or 120 HLC Consortium 10 billion viable cells Fructooligosaccharides (FOS) 100 mg Other ingredients: Cellulose, hypromellose, silica, vegetable magnesium stearate Adults and Children (6 years and older): One capsule taken 1-2 times daily with a meal, at least 2-3 hours before or after taking antibiotics, 60 vegetable capsules PB vegetable capsules PB Moderate level probiotic 10 billion CFU per serving Supports a healthy normal digestive flora* Includes fructooligosaccharides (FOS) Ideal for vegetarians Easy-to-take powder format increases compliance HLC High Potency Powder provides two strains of proprietary human-sourced Lactobacillus acidophilus, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis formulated to assist in re-establishing and maintaining normal intestinal microflora.* HLC High Potency Powder is indicated for the promotion and maintenance of intestinal health in adults and children who dislike or have difficulty swallowing capsules. Serving Size 1 /3 Teaspoon (1 g)/ Servings Per Container 60 or 120 Total Carbohydrate <1 g <1%u Dietary Fiber <1 g 2%u HLC Consortium 10 billion viable cells Fructooligosaccharides (FOS) 600 mg u % Daily Values (DV) are based on a 2,000 calorie diet Other ingredients: Apricot powder, fructose, apricot flavor Contains: Milk Adults and Children (1 year and older): In a glass, add water or milk to 1 /3 teaspoon (1 g) and mix. Take once daily with a meal, at least 2-3 hours before or after taking antibiotics, or as professionally directed. 2.1 oz (60 g) PB oz (120 g) PB EGETARIAN 4 *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

7 MAINTENANCE HLC ENDURE HLC MULTI STRAIN HLC INTENSIVE CAPSULES Moderate level maintenance probiotic 12.5 billion CFU per capsule Includes fructooligosaccharides (FOS) Ambient-safe Manufactured to allow for ambient temperature (59-86 F) storage and 2 year shelf-life without compromising product stability and still meet or exceed label claims. While refrigeration will extend the shelf-life of probiotics, HLC Endure provides a choice for practitioners who are concerned about product viability, but do not have refrigeration facilities. HLC Endure provides two strains of proprietary human-sourced Lactobacillus acidophilus, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis. Serving Size 1 Capsule/ Servings Per Container 30 HLC Consortium 12.5 billion viable cells Fructooligosaccharides (FOS) 100 mg Other ingredients: Microcrystalline cellulose, hypromellose, vegetable magnesium stearate, silica Adults and Children (4 years and older): Therapeutic use: One capsule taken two times daily with meals, at least 2-3 hours before or after taking Maintenance use: One capsule taken daily with a meal, at least 2-3 hours before or after taking 30 vegetable capsules PB22-30 Moderate level maintenance probiotic 15 billion CFU per capsule FOS 16 probiotic strains Including proprietary, human-sourced strains Supports a healthy normal digestive flora Provides live microorganisms that temporarily modify gut flora* HMF Multi Strain is a moderate-level, long-term maintenance probiotic formula which provides sixteen strains including proprietary human-sourced Lactobacillus acidophilus, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis. The capsules are 100% pure vegetable-sourced and ideal for vegans. Serving Size 1 Capsule/ Servings Per Container 60 Each Capsule Contains Probiotic Consortium 15 billion viable cells Lactobacillus salivarius (CUL-61) Lactobacillus paracasei (CUL-08) Lactobacillus plantarum (CUL-66) Lactobacillus casei (CUL-06) Lactobacillus fermentum (CUL-67) Lactobacillus gasseri (CUL-09) Bifidobacterium animalis subsp. lactis (CUL-62) Bifidobacterium breve (CUL-74) Streptococcus salivarius subsp. thermophilus (CUL-68) Lactobacillus acidophilus (NCFM ) Bifidobacterium animalis subsp. lactis (HN019) Lactobacillus rhamnosus (HN001) Other ingredients: Hypromellose, cellulose, silica Adults, Adolescents and Children (6 years and older): One capsule taken once daily or as professionally directed. Take at least 2-3 hours before or after taking antibiotics. 60 vegetable capsules PB34-60 High level probiotic 25 billion CFU per capsule FOS free HLC Intensive Capsules is a highly concentrated probiotic formula which provides two strains of proprietary human-sourced Lactobacillus acidophilus, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis to support the restoration of friendly intestinal flora.* It is fructooligosaccharidefree and ideal for vegans. HLC Intensive Capsules are highly recommended after completion of the HLC Synbiotic Intensive program. Serving Size 1 Capsule/ Servings Per Container 30 HLC Consortium 25 billion viable cells Other ingredients: Cellulose, hypromellose Adults and Children (6 years and older): One capsule taken daily with a meal, at least 2-3 hours before or after taking antibiotics, or as professionally directed. 30 vegetable capsules PB14-30 *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. 5

8 MAINTENANCE HLC INTENSIVE POWDER HLC REPLENISH CAPSULES HLC SYNBIOTIC INTENSIVE Highly concentrated probiotic formula 25 billion CFU per serving FOS free Easy-to-use powder formula for long-term maintenance Helps reduce symptoms associated with occasional intestinal discomfort* Helps restore intestinal flora* HLC Intensive Powder is a highly concentrated probiotic formula, which provides two strains of proprietary human-sourced Lactobacillus acidophilus, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis in a single daily-dose powder to support the restoration of friendly intestinal flora. HLC Intensive Powder is highly recommended after completion of the HLC Synbiotic Intensive program. Serving Size 1 Scoop (1 g)/ Servings Per Container 30 for for Adults & Children Children Years Years Total Carbohydrate <1 g <1 %u HLC Consortium 25 billion viable cells u % Daily Values (DV) are based on a 2,000 calorie diet Other ingredients: Maltodextrin Adults, Adolescents and Children (3 years and older): In a glass, add water or milk to one scoop of HLC Intensive Powder and mix. Take once daily with a meal, at least 2-3 hours before or after taking Net Wt 1 oz (30 g) PB33-30 High level probiotic 100 billion CFU per capsule Includes fructooligosaccharides (FOS) 14-day dosage Ideal for short-term colonization and support of gastrointestinal flora repopulation during and post antibiotic use* Ideal for vegans Convenient capsule format HLC Replenish Capsules provides two strains of proprietary human-sourced Lactobacillus acidophilus, Lactobacillus salivarius, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis. Serving Size 1 Capsule/ Servings Per Container 14 HLC Consortium 100 billion viable cells Lactobacillus salivarius (CUL-61) Other ingredients: Fructooligosaccharides (FOS), hypromellose, silica, vegetable magnesium stearate Adults and Children (6 years and older): One capsule taken daily with a meal, at least 2-3 hours before or after taking antibiotics, or as professionally directed. 14 vegetable capsules PB26-14 Intensive probiotic 150 billion CFU per sachet Includes fructooligosaccharides (FOS) Ideal for vegans Convenient sachet format HLC Synbiotic Intensive provides two strains of proprietary human-sourced Lactobacillus acidophilus, Lactobacillus salivarius, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis in high concentrations to ensure rapid establishment and dominance of probiotic cultures in the gastrointestinal tract.* Serving Size 1 Sachet (20 g)/ Servings Per Container 7 Calories 50 Sodium 5 mg <1%u Total Carbohydrate 18 g 6%u Dietary Fiber 10 g 41%u Sugars 8 g HLC Consortium 150 billion viable cells (formerly Bifidobacterium lactis) Lactobacillus salivarius (CUL-61) Fructooligosaccharides (FOS) 10 g u % Daily Values (DV) are based on a 2,000 calorie diet Other ingredients: Apricot powder Adults: In a glass, add water to one sachet (20 g) and mix. Take once daily with a meal, at least 2-3 hours before or after taking antibiotics, 7 x 0.7 oz (20 g) sachets PB08-7 (Net Wt 4.9 oz) 6 *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

9 POST ANTIBIOTIC CARE IMMUNE HEALTH HLC ANTIBIOTIC CARE HLC IMMUNITY + PRO Vitamin and HLC IMMUNOBIOTICS Probiotic for post antibiotic care Clinically proven to supplement the normal intestinal microbiota following antibiotic therapy 1 * 100 billion CFU per dose Includes fructooligosaccharides The Cambridge Probiotic/Antibiotic Trial concluded that this proprietary blend of Human Lactic Commensal (HLC) strains was effective in supplementing the normal microbiota after antibiotic usage. 1 Serving Size 1 Capsule/ Servings Per Container 14 HLC Consortium 100 billion viable cells Lactobacillus salivarius (CUL-61) Other ingredients: Fructooligosaccharides (FOS), hypromellose, silica, vegetable magnesium stearate Adults and Children (6 years and older): One capsule taken daily with a meal, at least 2-3 hours before or after taking antibiotics, or as professionally directed. 14 vegetable capsules PB Madden JAJ et al. Effect of probiotics on preventing disruption of the intestinal microflora following antibiotic therapy: A double-blind, placebocontrolled pilot study. Int Immunophar 2005: 5: A factor in the maintenance of good health* 1000 mg of vitamin C Includes vitamins and essential minerals Helps to maintain immune function* Low level long-term maintenance probiotic formula 2 billion CFU Proprietary, human-sourced HLC strains contribute to a natural healthy gut flora* Patient friendly dosing for improved compliance Convenient individualized sachets Great-tasting orange flavor Powder easily mixes into water or juice Ideal for vegetarians: dairy free, gluten free Serving Size 1 Sachet (8.42 g)/ Servings Per Container 30 Calories 20 Sodium 55 mg 2% Total Carbohydrate 6 g 2%u Sugars 5 g Vitamin C (ascorbic acid) 1000 mg 1667% Thiamin (thiamin hydrochloride) 0.38 mg 25% Riboflavin (riboflavin-5-phosphate sodium) 0.43 mg 25% Niacin 5 mg 25% Vitamin B 6 (pyridoxine hydrochloride) 10 mg 500% Folic acid 12.5 mcg 3% Vitamin B 12 (cyanocobalamin) 25 mcg 417% Pantothenic acid (calcium d-pantothenate) 2.5 mg 25% Calcium (calcium carbonate / calcium phosphate tribasic) 50 mg 5% Phosphorus (calcium phosphate tribasic) 13 mg 1% Magnesium (magnesium hydroxide / carbonate) 60 mg 15% Zinc (zinc ascorbate) 2 mg 13% Manganese (manganese gluconate) 0.5 mg 25% Chromium [chromium (III) polynicotinate] 10 mcg 8% Potassium (potassium bicarbonate / carbonate) 100 mg 3% HLC Consortium 2 billion viable cells u % Daily Values (DV) are based on a 2,000 calorie diet % Daily Value (DV) not established Other ingredients: D-fructose, citric acid, DL-malic acid, natural orange flavor, sodium bicarbonate, orange juice powder, maltodextrin (potato), silica, L-tartaric acid, glycine, annatto extract, beta-carotene Adults: In a glass, add water to one sachet of powder and mix. One sachet taken daily with a meal, a few hours before or after taking other medications, oz (8.42 g) sachets of powder VM54-30 [Net Wt 8.9 oz (253 g)] Highly concentrated probiotic 12.5 billion CFU per dose Enhanced immune support Supports immunity with zinc and echinacea* Enhances antioxidant levels with vitamin C and CoQ 10 * Unique manufacturing process Manufactured to allow for ambient temperature (59-86 F) storage and 2 year shelf-life without compromising product stability and still meet or exceed label claims. While refrigeration will extend the shelf-life of probiotics, HLC Immunobiotics provides a choice for practitioners who are concerned about product viability, but do not have refrigeration facilities. Ideal for vegetarians Convenient vegetable capsule format Serving Size 1 Capsule/ Servings Per Container 30 Vitamin C (ascorbic acid) 125 mg 208% Vitamin D (cholecalciferol) 500 IU 125% Thiamin (thiamin mononitrate) 4.2 mg 280% Riboflavin 4.8 mg 282% Niacin (niacinamide) 18 mg 90% Vitamin B 6 (pyridoxine hydrochloride) 6 mg 300% Folic acid 400 mcg 100% Vitamin B 12 (cyanocobalamin) 10 mcg 167% Biotin 200 mcg 67% Pantothenic acid (calcium d-pantothenate) 12 mg 120% Zinc (zinc citrate) 7.5 mg 50% Selenium (sodium selenite) 100 mcg 143% Coenzyme Q 10 (yeast fermentation) 30 mg Guaranà (Paullinia cupana) seed std. extract (11% caffeine) 70 mg Yeast (Saccharomyces cerevisiae) std. extract (70% beta-1,3-glucans) 60 mg European elder (Sambucus nigra) fruit juice powder 75 mg (equivalent to 0.45 ml fruit juice / 525 mg fresh fruit) Echinacea (Echinacea purpurea) root std. extract (4% echinacosides) 40 mg Propolis resin (from honey bee hive) 30 mg HLC Consortium 12.5 billion viable cells Other ingredients: Hypromellose, cellulose, silica, vegetable magnesium stearate Adults: One capsule taken two times daily with meals, at least 2-3 hours before or after taking 30 vegetable capsules PB23-30 EGETARIAN *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. 7

10 CONDITION-SPECIFIC SUPPORT COMPREHENSIVE RANGE IN CONVENIENT FORMATS For individualized treatment, HLC probiotics are available in an array of potencies and formulas to allow for flexibility and efficacy. HUMAN LACTIC COMMENSAL (HLC) PROBIOTICS COMPARISON CHART PRODUCT PRIMARY INDICATIONS VIABLE CELLS (CFU) PER DOSAGE UNIT STRAINS OTHER ACTIVE INGREDIENTS FOS RECOMMENDED DOSE MAINTENANCE HLC Maintenance (capsules) Low level maintenance 2.5 billion L. acidophilus (CUL-60) Yes Adults and Children (6 years and older): One capsule taken 1-2 times daily with a meal, at least 2-3 hours before or after taking HLC High Potency Capsules Moderate level maintenance 10 billion L. acidophilus (CUL-60) Yes Adults and Children (6 years and older): One capsule taken 1-2 times daily with meals, at least 2-3 hours before or after taking HLC High Potency Powder Moderate level maintenance 10 billion L. acidophilus (CUL-60) Yes Adults and Children (1 year and older): In a glass, add water or milk to 1 /3 teaspoon (1 g) and mix. Take once daily with a meal, at least 2-3 hours before or after taking antibiotics, or as professionally directed. HLC Endure (capsules) Moderate level maintenance 12.5 billion L. acidophilus (CUL-60) Yes Adults and Children (4 years and older): Therapeutic use: One capsule taken two times daily with meals, at least 2-3 hours before or after taking Maintenance use: One capsule taken daily with a meal, at least 2-3 hours before or after taking HLC Multi Strain (capsules) Moderate level maintenance 15 billion L. acidophilus (CUL-60) L. salivarius (CUL-61) L. paracasei (CUL-08) L. plantarum (CUL-66) L. casei (CUL-06) L. fermentum (CUL-67) L. gasseri (CUL-09) B. animalis subsp. lactis (CUL-62) B. breve (CUL-74) Streptococcus salivarius subsp. thermophilus (CUL-68) L. acidophilus (NCFM ) B. animalis subsp. lactis (HN019) L. rhamnosus (HN001) Adults, Adolescents and Children (6 years and older): One capsule taken once daily or as professionally directed. Take at least 2-3 hours before or after taking antibiotics. HLC Intensive Capsules Intensive use 25 billion L. acidophilus (CUL-60) B. animal subsp. lactis (CUL-34) HLC Intensive Powder Intensive use 25 billion L. acidophilus (CUL-60) B. animal subsp. lactis (CUL-34) Adults and Children (6 years and older): One capsule taken daily with a meal, at least 2-3 hours before or after taking antibiotics, Adults, Adolescents and Children (3 years and older): In a glass, add water or milk to one scoop of HLC Intensive Powder and mix. Take once daily with a meal, at least 2-3 hours before or after taking antibiotics, or as professionally directed. HLC Replenish Capsules Highest potency probiotic capsule for intensive use 100 billion L. acidophilus (CUL-60) L. salivarius (CUL-61) Yes Adults and Children (6 years and older): One capsule daily with a meal, at least 2-3 hours before or after taking antibiotics, HLC Synbiotic Intensive (powder) Highest potency probiotic powder for intensive use 150 billion L. acidophilus (CUL-60) L. salivarius (CUL-61 ) Yes Adults: In a glass, add water to one sachet (20 g) and mix. Take once daily with a meal, at least 2-3 hours before or after taking 8 These These statements have have not not been been evaluated by by the the Food Food and and Drug Drug Administration. These These products are are not not intended to diagnose, to treat, treat, cure cure or prevent or any any disease.

11 PRODUCT PRIMARY INDICATIONS VIABLE CELLS (CFU) PER DOSAGE UNIT STRAINS OTHER ACTIVE INGREDIENTS FOS RECOMMENDED DOSE DURING & POST ANTIBIOTIC CARE HLC Antibiotic Care IMMUNE HEALTH HLC Immunity + Pro (powder) HLC Immunobiotics (capsules) Clinically proven to supplement the normal intestinal microbiota following antibiotic therapy PREGNANCY AND CHILD SUPPORT HLC Toddler + Pro (powder) HLC Neonate (powder) HLC Child (chewable tablets) NEW NEW HLC Baby B HLC Baby F HLC Maternity (capsules) Formerly HLC Perinate NEW 100 billion L. acidophilus (CUL-60) L. salivarius (CUL-61) Immune support 2 billion L. acidophilus (CUL-60) 1000 mg of vitamin C, multivitamins & minersals Immune support 12.5 billion L. acidophilus (CUL-60) Complex nutrient blend Supports children 2.5 billion L. salivarius (CUL-61) L. paracasei (CUL-08) Probiotic specifically formulated for children Chewable probiotic specifically formulated for children Probiotic supplement for breast fed babies Probiotic supplement for formula fed babies Supports pregnant women 3 billion L. acidophilus (CUL-60) L. paracasei (CUL-08) B. animalis subsp. lactis (CUL-62) 4 billion L. acidophilus (CUL-60) (formerly B. lactis) L. salivarius (CUL-61 ) L. paracasei (CUL-08) 10 billion B. animalis subsp. lactis (CUL-34 L. salivarius (CUL-61) L. paracasei (CUL-08) 10 billion B. animalis subsp. lactis (CUL-34 L. salivarius (CUL-61) L. paracasei (CUL-08)) 10 billion L. salivarius (CUL-61) L. paracasei (CUL-08) Multivitamin and mineral blend, Transgalactooligosaccharides, Fruit blend Lactose monohydrate (milk) Galactooligosaccharides (GOS) Transgalacto oligosaccharides (GOS) (from milk) Yes Yes Yes Yes Adults and Children (6 years and older): One capsule daily with a meal, at least 2-3 hours before or after taking antibiotics, Adults: In a glass, add water to one sachet of powder and mix. One sachet taken daily with a meal, a few hours before or after taking other medications, Adults: One capsule taken two times daily with meals, at least 2-3 hours before or after taking Children (1-5 years): In a glass, add water or milk to one scoop of HLC Toddler + Pro and mix. Take once daily with a meal, at least 2-3 hours before or after taking antibiotics, Children (1-4 years): Add one level scoop (100 mg) of HLC Neonate powder into a single daily feeding of expressed breast or formula milk Take at least 2-3 hours before or after taking antibiotics. Children (4 years and older): Chew one tablet 1-2 times daily with a meal, at least 2-3 hours before or after taking antibiotics, Children (1-4 years): In a glass, add water or milk to one scoop of HMF Baby B and mix. Take once daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. Children (1-4 years): In a glass, add water or milk to one scoop of HMF Baby F and mix. Take once daily with a meal, at least two to three hours before or after taking antibiotics, or as recommended by your healthcare practitioner. Women: One capsule taken daily with a meal, at least 2-3 hours before or after taking HLC Maternity + Pro (capsules + softgels) Supports pregnant women 10 billion L. salivarius (CUL-61) L. paracasei (CUL-08) Multivitamin and mineral blend, DHA & EPA with beta carotene and vitamin E Women (19 years and older): One serrated strip, containing one capsule and one softgel, taken once daily with a meal or as professionally directed. Take a few hours before or after taking other medications, and at least 2-3 hours before or after taking antibiotics. Children (4 years and older): Chew one tablet once daily with a meal, at least 2-3 hours before or after taking antibiotics, or as professionally directed. HLC Child + Multi (chewable tablets) Multivitamin and daily probiotic specifically formulated for children 12.5 billion L. acidophilus (CUL-60) Various multivitamins EXORPHIN DEGRADING (in vitro) HLC MindLinx Capsules Exorphin degrading capacity in intestinallysimulated conditions HLC MindLinx Powder URINARY TRACT HEALTH HLC Uritol Maintenance (capsules) COLON SUPPORT HLC Colon-izer (powder) Exorphin degrading capacity in intestinallysimulated conditions Helps promote and maintain healthy urinary flow 12 billion L. acidophilus (CUL-60) L. rhamnosus (CUL-63) 12 billion L. acidophilus (CUL-60) L. rhamnosus (CUL-63) 2.5 billion L. acidophilus (CUL-60) Intensive use 40 billion L. acidophilus (CUL-60) B. animalis subsp. lactis (CUL-69) L-glutamine Adults: One capsule taken twice daily with a meal, at least 2-3 hours before or after taking L-glutamine Yes Adults: In a glass, add water to ¼ teaspoon (1 g) and mix. Take twice daily with a meal, at least 2-3 hours before or after taking Vitamin C, Cranberry fruit concentrate (36:1) Butyric acid, L-glutamine Adults: One capsule taken daily with half a glass of water before breakfast, at least 2-3 hours before or after taking antibiotics, or as professionally directed. Adults: Administer entire contents (6 g) as one dose, at least 2-3 hours before or after taking These These statements have have not been not been evaluated evaluated by the by Food the Food and and Drug Drug Administration. These These products products are not are intended not intended to diagnose, to diagnose, treat, treat, cure cure or prevent or prevent any disease. any disease. 9

12 PREGNANCY AND CHILD SUPPORT HLC MATERNITY + PRO Vitamin and Nutritional and probiotic supplement for pregnant women Includes the 4 major foundations of nutrition; vitamins and minerals, antioxidants, clinically proven human-sourced probiotics and omega-3 essential fatty acids 10 billion CFU per serving, from probiotic strains that are safe for use during pregnancy 1 Includes high DHA fish oil Each softgel provides 200 mg of DHA (docosahexaenoic acid) to help support cognitive health and brain function* Convenient & cost-effective combination Each package provides 28 easy-to-use portable strips (containing 1 vegetable capsule and 1 softgel per strip) HLC Maternity + Pro is a nutritional and probiotic supplement for pregnant women. Each serving of HLC Maternity + Pro provides 10 billion CFU of probiotic strains that are suitable for use during pregnancy, 1 plus vitamins, minerals, antioxidants, and 200 mg of DHA. HLC Maternity + Pro provides 100% of the recommended Daily Value for folate and 8 other vitamins (for pregnant and lactating women). Serving Size 1 Vegetable Capsule/ Servings Per Container 28 % DV for % DV for Adult Pregnant & Women Women Lactating Vitamin C (ascorbic acid) 150 mg 250% 250% Vitamin D (cholecalciferol) 1000 IU 250% 250% Vitamin K1 (phylloquinone) 75 mcg 94% Thiamin (thiamin mononitrate) 2.2 mg 147% 129% Riboflavin 2.8 mg 165% 140% Niacin (niacinamide) 32 mg 160% 160% Vitamin B6 (pyridoxine hydrochloride) 2.8 mg 140% 112% Folic acid 800 mcg 200% 100% Vitamin B12 (cyanocobalamin) 10 mcg 167% 125% Biotin 100 mcg 33% 33% Pantothenic acid (calcium d-pantothenate) 12 mg 120% 120% Calcium (calcium carbonate) 120 mg 12% 9% Iron (ferrous fumarate) 16 mg 89% 89% Iodine (potassium iodide) 150 mcg 100% 100% Magnesium (magnesium oxide) mg 14% 13% Zinc (zinc citrate) 10 mg 67% 67% Selenium (selenomethionine) 55 mcg 79% Copper [copper (II) citrate] 1 mg 50% 50% Manganese (manganese gluconate) 2 mg 100% Chromium [chromium (III) polynicotinate] 40 mcg 33% Molybdenum [sodium molybdate (VI)] 50 mcg 67% N-Acetyl-L-Cysteine 20 mg HLC Consortium 10 billion viable cells Lactobacillus salivarius (CUL-61) Lactobacillus paracasei (CUL-08) Other ingredients: Hypromellose, silica, vegetable magnesium stearate Serving Size 1 Softgel Capsule/ Servings Per Container 28 % DV for % DV for Adult Pregnant & Women Lactating Women Calories 5 Calories from Fat 5 Total Fat 0.5 g < 1%u Vitamin A (100% as beta-carotene) 4000 IU 80% 50% Vitamin E (d-alpha tocopheryl acetate) 15 IU 50% 50% Docosahexaenoic acid (DHA) 200 mg Eicosapentaenoic acid (EPA) 45 mg (DHA & EPA provided as tuna oil) u % Daily Values (DV) are based on a 2,000 calorie diet % Daily Value not established Other ingredients: Fish gelatin, glycerin Women (19 years and older): One serrated strip, containing one capsule and one soft-gel, taken once daily with a meal Take a few hours before or after taking other medications, and at least 2-3 hours before or after taking antibiotics. Vitamins, Minerals & Probiotics: 28 vegetable capsules + High DHA Omega-3 Fatty Acids: 28 soft-gel capsules) PB Allen SJ et al. Dietary Supplementation with Lactobacilli and Bifidobacteria Is Well Tolerated and t Associated with Adverse Events during Late Pregnancy and Early Infancy. The Journal of Nutrition. 2010; 140: *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

13 PREGNANCY AND CHILD SUPPORT HLC MATERNITY NEW HLC BABY B NEW HLC BABY F Formerly HLC Perinate Probiotic support for pregnant women Safe for use during infancy 10 billion CFU per capsule Temporarily modifies gut flora* Suitable for use during pregnancy Healthy intestinal bacteria are just as important to infants as to adults. Modern living may inhibit gut flora balance post birth. Thus the acquisition of a beneficial flora potential in the newborn can be significantly enhanced if the mother also takes a probiotic during pregnancy. Additionally, probiotics will help support the intestinal function of the mother during the pregnancy period.* Serving Size 1 Capsule/ Servings Per Container 30 HLC Consortium 10 billion viable cells Lactobacillus salivarius (CUL-61) Lactobacillus paracasei (CUL-08) Other ingredients: Maltodextrin, hypromellose Women: One capsule taken daily with a meal, at least 2-3 hours before or after taking antibiotics, 30 vegetable capsules PB29-30 Probiotic supplement for breast fed babies Safe for use during infancy A recent clinical trial found that this probiotic formula safely and effectively reduced incidence of skin sensitivity in infants 1 * 10 billion CFU per dose Helps support gastrointestinal and skin health* Promotes a favorable gut flora* HLC Baby B probiotic supplement for breast fed babies provides Lactobacillus salivarius, Lactobacillus paracasei, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis, which help to support gastrointestinal health.* Infant microflora composition also influences early immune stimulation, and may impact incidence of skin sensitivity.* HLC Baby B powder dissolves easily into milk, breast milk, or water. Serving Size 1 Scoop (200 mg)/ Servings per Container 30 Each Serving Contains HLC Consortium 10 billion viable cells Lactobacillus salivarius (CUL-61) Lactobacillus paracasei (CUL-08) Other ingredients: Transgalactooligosaccharides (GOS) (from milk) Contains: Milk Children (1-4 years): In a glass, add water or milk to one scoop of HLC Baby B and mix. Take once daily with a meal, at least 2-3 hours before or after taking antibiotics, or as professionally directed 0.2 oz (6 g) PB28-6 EGETARIAN 1. Allen SJ et al. Arch. Dis. Child. 2014; 99(11): Probiotic supplement for formula fed babies A recent clinical trial found that this probiotic formula safely and effectively reduced incidence of skin sensitivity in infants 1 * 10 billion CFU per dose Helps support gastrointestinal and skin health* Promotes a favorable gut flora* HLC Baby F probiotic supplement for formula fed babies provides Lactobacillus salivarius, Lactobacillus paracasei, Bifidobacterium bifidum and Bifidobacterium animalis subsp.lactis, which help to support gastrointestinal health.* Infant microflora composition also influences early immune stimulation, and may impact incidence of skin sensitivity.* HLC Baby F contains galactooligosaccharides (GOS), a type of prebiotic fiber similar to oligosaccharides naturally found within breast milk. Fructooligosaccharides (FOS) are also included for additional prebiotic fiber content. HMF Baby F powder dissolves easily into milk or water. Serving Size 1 Scoop (1.1 g)/ Servings Per Container 60 Total Carbohydrate 1 g HLC Consortium 10 billion viable cells Lactobacillus salivarius (CUL-61) Lactobacillus paracasei (CUL-08) Other ingredients: Transgalactooligosaccharides (GOS) (from milk), fructooligosaccharides (FOS) Contains: Milk Children (1-4 years): In a glass, add water or milk to one scoop of HLC Baby F and mix. Take once daily with a meal, at least 2-3 hours before or after taking antibiotics, 2.3 oz (66 g) PB27-66 EGETARIAN 1. Allen SJ et al. Arch. Dis. Child. 2014; 99(11): *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. 11

14 PREGNANCY AND CHILD SUPPORT HLC TODDLER + PRO Vitamin and HLC CHILD + MULTI Vitamin and Complete vitamin and probiotic combination for toddlers Includes vitamins, minerals, antioxidants and research-driven human-sourced probiotics Supports growth and development* Helps to maintain eyesight, skin, membranes and immune function* Provides 2.5 billion CFU of probiotics that promote a favorable microflora composition* Added GOS and FOS prebiotic fibers support gastrointestinal microflora* Great-tasting berry flavor HLC Toddler + Pro supports pediatric nutrition and intestinal health with a unique consortium of human-sourced probiotic strains, plus over 10 vitamins.* Vitamins A, C, D, and K support the development and maintenance of bones, cartilage, teeth and gums.* Red blood cell formation and macronutrient metabolism are supported with vitamins B 1, B 2, B 3, B 5, B 6, biotin, folate and B 12.* Serving Size 1 Scoop (1 g)/ Servings Per Container 60 for for Children Children 1-3 Years 4+ Years Total Carbohydrate <1 g <1%u Vitamin A (vitamin A acetate) 1333 IU 53% 27% Vitamin C (ascorbic acid) 40 mg 100% 67% Vitamin D (cholecalciferol) 200 IU 50% 50% Vitamin E (d-alpha tocopheryl acetate) 9 IU 90% 30% Vitamin K 1 (phylloquinone) 30 mcg 38% Thiamin (thiamin mononitrate) 0.55 mg 79% 37% Riboflavin 0.7 mg 88% 41% Niacin (niacinamide) 8 mg 89% 40% Vitamin B 6 (pyridoxine hydrochloride) 0.7 mg 100% 35% Folic acid 100 mcg 50% 25% Vitamin B 12 (methylcobalamin) 1.25 mcg 42% 21% Biotin 25 mcg 17% 8% Pantothenic acid (calcium d-pantothenate) 3 mg 60% 30% HLC Consortium 2.5 billion viable cells Lactobacillus salivarius (CUL-61) Lactobacillus paracasei (CUL-08) u % Daily Values (DV) are based on a 2,000 calorie diet Other ingredients: Fructooligosaccharides (FOS), transgalactooligosaccharides, fruit blend (strawberry, blackberry, blackcurrant, bilberry, elderberry), xylitol, natural strawberry flavor Contains: Milk Children (1 5 years): In a glass, add water or milk to one scoop of HLC Toddler + Pro and mix. Take once daily with a meal, at least 2-3 hours before or after taking Moderate level probiotic + vitamins 12.5 billion CFU per tablet Source of 13 vitamins Unique manufacturing process Utilized to help maintain high potency probiotic stability in combination with multivitamins Ambient-safe Manufactured to allow for ambient temperature (59-86 F) storage and 2 year shelf-life without compromising product stability and still meet or exceed label claims. While refrigeration will extend the shelf-life of probiotics, ambient-safe HLC Child + Multi provides a choice for practitioners who are concerned about product viability but do not have refrigeration facilities. Great taste Natural blackcurrant flavor HLC Child + Multi probiotic formula provides two strains of Lactobacillus acidophilus, Bifidobacterium bifidum and Bifidobacterium animalis subsp. lactis, essential to the maintenance of the child s healthy gut flora. HLC Child + Multi provides an easy and enjoyable way for children to obtain daily multivitamins to support overall health.* Serving Size 1 Tablet/ Servings Per Container 30 Vitamin A (vitamin A acetate) 1333 IU 27% Vitamin C (ascorbic acid) 100 mg 167% Vitamin D (cholecalciferol) 500 IU 125% Vitamin E (d-alpha tocopheryl acetate) 30 IU 100% Vitamin K1 (phylloquinone) 25 mcg 31% Thiamin (thiamin mononitrate) 1.4 mg 93% Riboflavin 1.6 mg 94% Niacin (niacinamide) 7.5 mg 38% Vitamin B6 (pyridoxine hydrochloride) 2 mg 100% Folic acid 200 mcg 50% Vitamin B12 (cyanocobalamin) 50 mcg 833% Biotin 150 mcg 50% Pantothenic acid (calcium d-pantothenate) 6 mg 60% HLC Consortium 12.5 billion viable cells Other ingredients: Xylitol, natural blackcurrant flavor, silica, vegetable magnesium stearate, thaumatin Children (4 years and older): Chew one tablet taken once daily with a meal, at least 2-3 hours before or after taking 30 chewable tablets PB24-30 Net wt 2.1 oz (60 g) EGETARIAN PB31-60 EGETARIAN 12 *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

15 PREGNANCY AND CHILD SUPPORT URINARY SUPPORT HLC CHILD HLC NEONATE HLC URITOL MAINTENANCE Probiotic formula for children Provides 4 billion CFU per dose Great taste Natural blackcurrant flavor increases compliance Ideal for vegans Convenient chewable tablet format HLC Child probiotic formula is a low level probiotic combination providing Lactobacillus acidophilus, Bifidobacterium bifidum, Lactobacillus paracasei, Lactobacillus salivarius and Bifidobacterium animalis subsp. lactis, essential to the maintenance of the child s healthy gut flora.* Serving Size 1 Tablet/ Servings Per Container 30 Total Carbohydrate <1 g <1% u HLC Consortium 4 billion viable cells (formerly Bifidobacterium lactis) Lactobacillus salivarius (CUL-61) Lactobacillus paracasei (CUL-08) u % Daily Values (DV) are based on a 2,000 calorie diet Other ingredients: Sorbitol, xylitol, natural blackcurrant flavor, silica, magnesium stearate Children (4 years and older): Chew one tablet 1-2 times daily with a meal, at least 2-3 hours before or after taking 30 chewable tablets PB21-30 Beneficial dose 3 billion CFU per dose Easy-to-use Add 1 scoop (100 mg) to milk or water Ideal for vegetarians Convenient powder format HLC Neonate child probiotic formula provides two strains of Lactobacillus acidophilus, Lactobacillus paracasei and Bifidobacterium animalis subsp. lactis, which contribute to a healthy intestinal microflora in children (1-4 years).* Serving Size 1 Scoop (100 mg)/ Servings Per Container 60 HLC Consortium 3 billion viable cells Lactobacillus paracasei (CUL-08) Bifidobacterium animalis subsp. lactis (CUL-62) Other ingredient: Lactose monohydrate (milk) Children (1-4 years): Add one level scoop (100 mg) of HLC neonate powder into a single daily feeding of expressed breast or formula milk or as professionally directed. Take at least 2-3 hours before or after taking antibiotics. Nt wt 0.2 oz (6 g) EGETARIAN PB10-6 Low level probiotic 2.5 billion CFU per capsule Includes cranberry fruit concentrate (36:1) Helps promote urinary tract health and provides antioxidants for the maintenance of good health* Convenient capsule format Increases patient compliance HLC Uritol Maintenance provides two strains of proprietary human-sourced Lactobacillus acidophilus formulated for the support and maintenance of a healthy gut microflora.* Serving Size 1 Capsule/ Servings Per Container 30 Vitamin C (as ascorbic acid) 60 mg 100% Cranberry (Vaccinium macrocarpon) fruit concentrate (36:1) 195 mg (equivalent to 7 g of fresh fruit) HLC Consortium 2.5 billion viable cells Other ingredients: Fructose, hypromellose, powdered cellulose, silica, vegetable magnesium stearate Adults: One capsule taken daily with half a glass of water before breakfast, at least 2-3 hours before or after taking antibiotics, or as professionally directed. 30 vegetable capsules PB18-30 *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. 13

16 EXORPHIN-DEGRADING (in vitro) COLON SUPPORT HLC MINDLINX CAPSULES HLC MINDLINX POWDER HLC COLON-IZER Probiotic formula 12 billion CFU per capsule Includes L-glutamine HLC MindLinx Capsules provides two strains of proprietary human-sourced Lactobacillus acidophilus, Bifidobacterium bifidum, Bifidobacterium animalis subsp. lactis and Lactobacillus rhamnosus to help maintain the integrity and health of the intestinal tract.* Serving Size 1 Capsule/ Servings Per Container 60 HLC Consortium 12 billion viable cells Lactobacillus rhamnosus (CUL-63) L-glutamine 250 mg Other ingredients: Hypromellose, silica, vegetable magnesium stearate Adults: One capsule taken twice daily with a meal, at least 2-3 hours before or after taking antibiotics, 60 vegetable capsules PB19-60 Probiotic formula 12 billion CFU per serving Includes L-glutamine Includes fructooligosaccharides (FOS) Ideal for vegans Convenient powder format HLC MindLinx Powder provides two strains of proprietary human-sourced Lactobacillus acidophilus, Bifidobacterium bifidum, Bifidobacterium animalis subsp. lactis and Lactobacillus rhamnosus to help maintain the integrity and health of the intestinal tract.* Serving Size 1 /4 Teaspoon (1 g)/ Servings Per Container 60 HLC Consortium 12 billion viable cells Lactobacillus rhamnosus (CUL-63) L-glutamine 500 mg Fructooligosaccharides (FOS) 250 mg Other ingredients: Apricot powder Adults: In a glass, add water to 1 /4 teaspoon (1 g) and mix. Take twice daily with a meal, at least 2-3 hours before or after taking antibiotics, or as professionally directed. Intensive probiotic formula 40 billion CFU per serving Includes L-glutamine and butyric acid HLC Colon-izer is a highly concentrated probiotic formula in powder which provides two strains of proprietary human-sourced Lactobacillus acidophilus, Bifidobacterium bifidum and two strains of Bifidobacterium animalis subsp. lactis to help maintain healthy flora in the gastrointestinal tract.* Serving Size 6 g/ Servings Per Container 1 Calories 20 Calcium (calcium butyrate) 310 mg 31%u HLC Consortium 40 billion viable cells Bifidobacterium animalis subsp. lactis (CUL-69) Butyric acid (calcium/magnesium butyrate) 2.5 g L-glutamine 2 g u % Daily Values (DV) are based on a 2,000 calorie diet Adults: Administer entire contents (6 g) as one dose, at least 2-3 hours before or after taking Nt Wt 2.1 oz (60 g) PB20-60 Nt Wt 0.2 oz (6 g) PB *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

17 Probiotic Clinical Trials Safe and effective strains reflecting the latest evidence-based research from human trials Pharmax HLC probiotic strains have been proven over the last 30 years to be effective in restoring intestinal balance. This section provides a detailed overview of the latest trials conducted on human-derived HLC probiotic strains, specifically the results from research that studied HLC probiotics and their effect in reducing skin sensitivity in young children, reducing occasional GI symptoms and maintaining a healthy microflora with antibiotic use. The Swansea Baby Trial Probiotics in the Prevention of Skin Sensitivity: A Randomised Controlled Trial (Allen at al. 2014) Probiotic supplementation was found to safely and effectively reduce incidence of skin sensitivity. In a randomized, double-blind, placebo-controlled, parallel group trial, 454 pregnant women at 36 weeks of gestation were assigned to either the probiotic capsule treatment group (10 billion CFU from Lactobacillus salivarius CUL61, Lactobacillus paracasei CUL08, Bifidobacterium animalis subsp. lactis CUL34 and Bifidobacterium bifidum CUL20) or the placebo capsule group. Participants began daily supplementation until giving birth; participants infants then began daily supplementation until 6 months of age. Skin sensitivity was evaluated at 6 months and 2 years of age. In comparison with the infant participants in the placebo group, participants in the probiotic group experienced a statistically significant 57% decrease in skin sensitivity. 57% decrease in skin sensitivity increase in adverse event incidence in infants Skin Sensitivity at 2 Years Percent Placebo Group 12.10% Probiotic Group 5.30% Reduced Atopic Skin Sensitivity Eczema at 2 Years in Probio7c Probiotic Group 14.00% 12.00% 10.00% 8.00% * 6.00% 4.00% 2.00% 0.00% Placebo Group Probio6c Probiotic Group Group * p < 0.05 These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. 15

18 The Sheffield Trial Clinical Trial: a Multistrain Probiotic Preparation Significantly Reduces Intestinal Discomfort in a Double-Blind Placebo-Controlled Study (Williams et al. 2008) Probiotic supplementation was found to decrease the number of days with intestinal discomfort, while improving satisfaction with bowel habits and overall quality of life. This 8-week long, double-blind, randomized, placebo-controlled study was conducted in 52 participants. Participants were randomized to either the placebo capsule group or the probiotic capsule group (25 billion CFU from Lactobacillus acidophilus CUL60 and CUL 21, Bifidobacterium animalis subsp. lactis CUL34, and Bifidobacterium bifidum CUL20). Participants scored their intestinal discomfort (including bloating, satisfaction with bowel habits, and quality of life) at baseline and every 2 weeks during supplementation. In the probiotic group, satisfaction with bowel habits was significantly improved in just 6 weeks, and quality of life scores were improved after 8 weeks of supplementation. 22% decrease in days with intestinal discomfort 32% improvement in satisfaction with bowel habits Intestinal Discomfort Scores Probiotic Group Placebo Group Before Supplementation At 8 Weeks of ation % Change at Week ation Reduces IBS Intestinal Symptom Discomfort Severity Scores * Before Supplementation At 8 Weeks of Probiotic Supplementation * p < These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.