PRIORITY LIST OF SUBSTANCES PROPOSED FOR EVALUATION BY JECFA

Transcription

1 PRIORITY LIST OF SUBSTANCES PROPOSED FOR EVALUATION BY JECFA (Source: REPORT OF THE FORTY-NINTH SESSION OF THE CODEX COMMITTEE ON FOOD ADDITIVES REP17/FA Appendix XI) Substance(s) 5 -Deaminase from Streptomyces murinus Acid prolyl endopeptidase from Aspergillus niger expressing a gene from Aspergillus niger D-Allulose 3-epimerase from Arthrobacter globiformis expressed in Escherichi coli Alpha-amylase from Bacillus licheniformis expressing a modified alpha-amylase gene from Geobacillus stearothermophilus Alpha-amylase from Bacillus stearothermophilus expressed in Bacillus licheniformis Alpha-amylase from Rhizomucor pusillus expressed in Aspergillus niger Amyloglucosidase from Talaromyces emersonii expressed in Aspergillus niger Asparaginase from Aspergillus niger expressing a modified gene from Aspergillus niger Asparaginase from Pyrococcus furiosus expressed in Bacillus subtilis Beta-amylase from Bacillus flexus expressed in Bacillus licheniformis Beta-glucanase from Streptomyces violaceoruber expressed in S. violaceoruber May 2017 and establishment of of of of of of of of of of of Matsutani Chemical Industry Co. Ltd. Mr. Yuma Tani (yuma-tani@matsutani.co.jp) Ms. Lisa Jensen (lisa.jensen@dupont.com) Ms. Lisa Jensen (lisa.jensen@dupont.com) (kensaku.uzura@ncx.nagase.co.jp)

2 Carob bean gum (INS 410) Citric and Fatty Acid Esters of Glycerol (INS 472 c) Collagenase from Streptomyces violaceoruber expressed in S. violaceoruber Bacillus subtilis produced B. subtilis LMG S Pseudoalteromonas haloplanktis produced B. subtilis, strain LMG S Thermotoga maritima produced B. subtilis, strain LMG S Flavouring substances (3 new + 27 from previous Priority Lists + 1 for re-evaluation + 39 for which JECFA requested additional info = 70 total) Gellan gum (INS 418) (Pending confirmation of technological justification from CCNFSDU) Glucose oxidase from Penicillium chrysogenum expressed in Aspergillus niger Glycerol ester of wood rosin (GEWR) (INS445(iii)) Gold (INS 175) INS 1205 Basic methacrylate Data pending toxicological data from studies on neonatal animals, adequate to evaluate the safety for use in infant formulas Revision of to allow for salts of sodium, potassium, and calcium as neutralizing agents for CITREM and establishment of Safety assessment or re-assessment, and establishment of or revision of, as applicable Safety assessment for use in infant formula, formula for special medical purposes for infants, and follow-up formula Revision of to allow for additional species of pine as source materials Safety assessment on use as a glazing/coating agent on food supplements (FC 13.6), and establishment of during CCFA50 during CCFA50 EFEMA Ms. Caroline Rey (efema@ecco-eu.com) (kensaku.uzura@ncx.nagase.co.jp) IOFI Dr. Sean V. Taylor (staylor@vertosolutions.net) Abbott Nutrition Mr. Paul Hanlon (paul.hanlon@abbott.com) Resinas Sineticas Mr. Vasilios Fotopoulos (vasilios@trchemicals.com) (IFAC will also provide data.)

3 INS 1206 Neutral methacrylate INS 1207 Anionic Methacrylate Inulinase from Aspergillus ficuum produced Aspergillus oryzae, strain MUCL Lactase from Bifidobacterium bifidum expressed in Bacillus licheniformis Lipase from Aspergillus oryzae expressing a modified gene from Thermomyces lanuginosus Lipase from Mucor javanicus Lutein from Tagetes erecta (INS 161b(i)) Natamycin (INS 235) 7 Nisin (INS 234) 7 Phosphatidyl inositol-specific phospholipase C from a genetically modified strain of Pseudomonas fluorescens Safety assessment on use as a glazing/coating agent on food supplements (FC 13.6), and establishment of Safety assessment on use as a glazing/coating agent on food supplements (FC 13.6), and establishment of Safety evaluation when used as and establishment of. Re-evaluation of safety to extend the ADI of 'not specified' for Lutein esters of Tagetes erecta to Lutein from Tagetes erecta, and revision of Revision of with respect to melting range. Re-evaluation of safety and revision of due to emerging data on natamycin's role in promoting antimicrobial resistance, as well as speeding up virulence and pathogenic potential of food-borne human pathogens Re-evaluation of safety and revision of due to emerging data on nisin's role in promoting antimicrobial resistance, as well as speeding up virulence and pathogenic potential of food-borne human pathogens 7 To be addressed JECFA or other mechanisms through the FAO/WHO Scientific Advice Programme Switzerland Russian Federation Russian Federation Bas Verhagen (bverhagen@puratos.com) Novozymes Novozymes DSM Nutritional Products Europe Ltd Mr. Dirk Cremer (dirk.cremer@dsm.com) Federal Research Centre of Nutrition, Biotechnology and Food Safety (codex@ion.ru) Federal Research Centre of Nutrition, Biotechnology and Food Safety (codex@ion.ru)

4 Phosphodiesterase from Penicillium citrinum Phospholipase A2 from pig pancreas expressed in Aspergillus niger Phospholipase A2 from Streptomyces violaceoruber expressed in S. violaceoruber Protease Aqualysin 1 from Thermus aquaticus produced B. subtilis, strain LMGS Rosemary extract (INS 392) Silver (INS 174) Sodium sorbate (INS 201) Spirulina extract Steviol glycosides (INS 960) Steviol Glycosides (Rebaudioside M) Transglucosidase/alpha-glucosidase from Trichoderma reesei expressing an Alpha-glucosidase gene from Aspergillus niger Safety evaluation when used as and establishment of. Data availability 2015 (1) Data pending studies to elucidate the potential developmental and reproductive toxicity (2) Data pending validation information on the method of determination of residual solvents (3) Data pending data on typical use-levels in food for use as a colour (1) Data pending method of assay to replace the existing method of, to include as many steviol glycosides as possible, along with supporting validation information and chromatograms (2) Data pending analysis of at least 5 batches of commercial samples, including chromatograms Safety evaluation of Rebaudioside M manufactured from two strains of yeast from the saccharomyces family, and establishment of standalone CCFA 49 (kensaku.uzura@ncx.nagase.co. jp) Bas Verhagen (bverhagen@puratos.com) IACM Sarah Codrea (scodrea@vertosolutions.net) CCC Ms Allison Cooke (acooke@caloriecontrol.org) Intertek Scientific & Regulatory Consultancy Dr. Ashley Roberts (ashley.roberts@intertek.com) Dr. Vincent J. Sewalt (vincent.sewalt@dupont.com)

5 Xylanase from Bacillus licheniformis expressed in B. licheniformis Xylanase from Talaromyces emersonii expressed in Aspergillus niger Brilliant Black Colours for re-evaluation Re-evaluation of safety and Erythrosine (INS 127) Re-evaluation of safety and Indigotine (INS 132) Re-evaluation of safety and Red 2G Re-evaluation of safety and CCFA46 (data from ; IACM; EU) CCFA46 (data from ; IACM; EU) May 2017