POPULATION BIOBANKS INTEGRATED IN THE SPANISH NATIONAL BIOBANK NETWORK
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1 Roma, 9/03/2012 POPULATION BIOBANKS INTEGRATED IN THE SPANISH NATIONAL BIOBANK NETWORK BBMRI.es Manuel M Morente Spanish National Biobank Network ISCIII
2 Population Biobanks integrated In the Spanish National Biobank Network Spanish population Population-based biobanks National DNA Bank Basque Country biobank Collaborative framework
3 Spanish population Population: people Updated: Males: (49,33 %) Females: (50,67 %)
4 Spanish population: Immigration Immigrants: 5.751,500 (12,18%) Update:
5 Population biobanks in Spain National DNA-Bank Regional & local actions: Basque Country Castilla y León Murcia Andalusia Navarra Valencia. Others
6 SPANISH NATIONAL DNA-BANK Universidad de Salamanca & ISCIII
7 National DNA-Bank (Salamanca University) Spanish National DNA Bank is a Biological Resource created in 2004 as an initiative of Spain Genome Foundation, with the support of the Regional Government of Castilla/León and the University of Salamanca. From 2010 is funded by the Spanish National Institute of Health Carlos III. Central node is located in Salamanca. P3G member. BBMRI preliminary phase member.
8 National DNA-Bank (University of Salamanca & ISCIII) Neuropsychiatric diseases Metabolic diseases Healthy population Oncological diseases Cardiovascular diseases Collections: Population-based General population (Spain) General population (Castilla and León) Trios (Father + mother + adult son/daughter). > 89 years old population. Twins (only females) Disease oriented: Metabolic diseases Oncological diseases Neuropsychiatric diseases Cardiovascular diseases Miscellaneous: Fibromialgia, Chronic fatigue syndrome, Mastocytosis, Neurofibromatosis. Chronic inflammatory & autoimmunity diseases
9 National DNA-Bank (University of Salamanca & ISCIII) Collection: Healthy donors Collection Healthy controls Description Healthy population resident in Spain Territorial coverage Spain Donors Un-related individuals (M:F = 40% : 60%) Number of cases Samples RNA DNA PB cells Plasma Urine Lb lines (*) Including general epidemiological questionnaire. Update: November 2011 PB = Peripheral blood Lb = Lymphoblastoid
10 National DNA-Bank (University of Salamanca & ISCIII) Collection: genomes (trios) Collection genomes Description Spanish population representative trios Territorial coverage Spain Donors Familiar trios (father + mother + adult son/daughter) Number of cases 198 Samples RNA 0 DNA 198 PB cells 198 Plasma 198 Urine 0 Lb lines 177 (*) Including general epidemiological questionnaire. Update: November 2011 PB = Peripheral blood Lb = Lymphoblastoid
11 National DNA-Bank (University of Salamanca & ISCIII) Collection: Nonagenarians and centenarians Collection Nonagenarians & centenarians Description >89 y.o. population Territorial coverage Spain Donors Un-related individuals (M:F = 20% : 80%) Number of cases 105 Samples RNA 0 DNA 105 PB cells 105 Plasma 105 Urine 0 Lb lines 0 (*) Including general epidemiological questionnaire. Update: November 2011 PB = Peripheral blood Lb = Lymphoblastoid
12 General epidemiologic questionnaire Anthropometric data Physical activity Work environment Alimentary habits Toxics: alcohol, tobacco. Demographic data Educational level Genealogy Diseases National DNA-Bank (Salamanca University)
13 National DNA-Bank (University of Salamanca & ISCIII) Collection: Cardiovascular risk factors Consejería de Sanidad Collection Cardiovascular risk factors in C&L Description General population in C&L (*) Territorial coverage Castilla & León (C&L) Donors Un-related individuals Number of cases Samples RNA 0 DNA PB cells 0 Plasma 0 Urine 0 Lb lines 0 (*) Including specific epidemiological questionnaire (cardiovascular risk factors). Update: November 2011 PB = Peripheral blood Lb = Lymphoblastoid
14 National DNA-Bank (Salamanca University) Collection: Cardiovascular risk factors Associated data Demographic: Age, gender, location, rural/urban. Clinical antecedents: Cardiovascular disease, anti-hypertension, anti-diabetes and/or antihiperlipemia treatments. Habits: Tobacco, diet, activity, etc. Consejería de Sanidad Clinical exploration: blood pressure, weight, height, abdominal circumference. Analytics: basal glucose, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides...
15 National DNA-Bank (University of Salamanca & ISCIII) Collection: Twin females Collection Twins (only females) Description Female twins. Territorial coverage Region of Murcia Donors Twins Number of cases 743 Samples RNA 0 DNA 743 PB cells 743 Plasma 743 Urine 0 Lb lines 20 (*) Including general epidemiological questionnaire. Update: November 2011 PB = Peripheral blood Lb = Lymphoblastoid
16 Biobank for research of the Basque Country Basque Government
17 Basque Country Biobank The Basque Country Biobank is an initiative of the Basque Government with a Network designed biobank organization and the participation of the Public Health System hospitals, the Regional Central Blood Bank, and other private institutions. It runs as the DNA extraction central node for Spanish participation in EPIC study. Coordination node is located in Bilbao.
18 Population based collections: Basque Country Biobank Collection Basque country residents 1 Description Residents (basic questionnaire) Territorial coverage Basque country Donors Blood donors Questionnaire Basic: Health, residence, gender, age Number of cases Samples DNA, serum & plasma Collection Basque country residents 2 Description Residents (extended questionnaire) Territorial coverage Basque country Donors Blood donors Questionnaire Basic + habits Number of cases Samples DNA, serum & plasma
19 Population based collections: Basque Country Biobank Collection Description Territorial coverage Donors Questionnaire Number of cases Samples Autochthonous population Autochthonous population Basque country and Navarra Familiar trios (father + mother + adult son/daughter), living in Basque Country or Navarra for, at least, three generations. Demographic, health, analitics 250 (82 trios) DNA, serum, plasma and immortalised lymphocytes
20 Population based collections: Basque Country Biobank Collection EPIC ( ) Description EPIC - IARC Territorial coverage Guipuzkoa Donors Healthy donors Questionnaire Demographic, diet, habits (15 years) Number of cases Samples DNA, serum, plasma
21 Population based collections: Collection INMA project Basque Country Biobank Description INMA: Childhood and Environment Territorial coverage Guipuzkoa Donors Pregnant women Questionnaire Demographic, habits, environment. Number of cases 360 Samples DNA, serum, plasma and placenta
22 Population based collections: Collection Newborns (*) Basque Country Biobank Description Neonatal Cribbage Samples Territorial coverage Basque Country Donors Newborns ( ) Questionnaire NO Number of cases Samples FTA cards, DNA (*) Approbation by the Basque Country Ethic Committee is still in progress.
23 BBMRI.es Spanish National Biobank Network -BBMRI.es- National Institute of Health Carlos III
24 Spanish National Biobank Network National coordination hub Local Networks Associated Biobanks Hospitals Universities Server providers It is a cooperative platform of biobanks promoted by the National Institute of Health (Instituto de Salud Carlos III), including: Population-based biobanks Disease-oriented biobanks 64 institutions, mainly hospital based. Main goals: Integration Harmonization Public service. BBMRI-ERIC.es The coordination node is based in Madrid.
25 Ethics and Biobanking Some PERSONAL thinking about ethics: Balance between personal (priority) and social rights. Donors rights have to be protected Autonomy principle means to guarantee the donor wishes What and how donors want to be protected? >90% one IC forever >95%... Trust on public biobanks and researcher activities. An over-guarantist legacy and/or ethicists recommendation can be against: Science Society Personal wishes AUTHONOMY PRINCIPLES If the wheel runs, do not re-invent the wheel
26 Acknowledgements A. Orfao BNADN-ISCIII Castilla & León E. de Álava BNADN-ISCIII Castilla & León A. Gª Montero BNADN-ISCIII Castilla & León R. Bilbao O+ehun Basque Country A.I. Sáez BBPA Andalusia J. Júdez FFIS Murcia J. Martínez-Santamaría CSISP Valencia BBMRI.es
27 National DNA-Bank (University of Salamanca & ISCIII) Collection: Cardiovascular risk factors Consejería de Sanidad % cases Age distribution n =
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