Coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC) study
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1 Coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC) study A. Attached below are the beta coefficients from the Cox regression models for the full models presented in Table 4 (Rows 2,4) of the referenced paper. The total cholesterol and HDL cholesterol variables were categorized as follows, and sometimes further collapsed as indicated in the individual models, e.g, tccat23 means that total cholesterol categories 2 and 3 were combined. Total cholesterol <200 mg/dl tccat = 1 200<=tc<240 tccat = 2 240<=tc<280 tccat = 3 280<=tc tccat = 4 hdl < 35 mg/dl hdlcat = 1 35 <= hdl01 < 45 hdlcat = 2 45 <= hdl01 < 50 hdlcat = 3 50 <= hdl01 < 60 hdlcat = 4 60 <= hdl01 hdlcat = 5 NEWAGE=(AGE - 55)/10 Page 1 of 5
2 Black Females NEWAGE NEWAGE tccat TCCAT HDLCAT hdlcat HDLCAT SBP (mmhg) HYPT MEDS DIABETES CUR SMK0KING BMI (kg/m 2 ) IMT (mm) Lp(a) (µg/ml) vwf (%) FIBRINOGEN(mg/dl) FEV 1 residual(l) HR (beats/min) PACK-YR Cigs WAIST/HIP KEYS SCORE SPORT Activity Factor VII Black Males NEWAGE NEWAGE TCCAT TCCAT TCCAT HDLCAT hdlcat HDLCAT SBP HYPT MEDS DIABTS CUR SMK0KING BMI IMT (mm) Lp(a) (µg/ml) vwf (%) FIBRINOGEN(mg/dl) FEV 1 residual(l) HR (beats/min) PACK-YR Cigs WAIST/HIP KEYS SCORE SPORT Activity Factor VII (%) Page 2 of 5
3 White Females NEWAGE NEWAGE TCCAT TCCAT TCCAT HDLCAT hdlcat HDLCAT SBP HYPT MEDS DIABTS CUR SMK0KING BMI IMT (mm) Lp(a) (µg/ml) vwf (%) FIBRINOGEN(mg/dl) FEV 1 residual(l) HR (beats/min) PACK-YR Cigs WAIST/HIP KEYS SCORE SPORT Activity Factor VII (%) White Males NEWAGE NEWAGE TCCAT tccat HDLCAT HDLCAT HDLCAT HDLCAT SBP HYPT MEDS DIABTS CUR SMK0KING BMI IMT (mm) Lp(a) (µg/ml) vwf (%) FIBRINOGEN(mg/dl) FEV 1 residual(l) HR (beats/min) PACK-YR Cigs WAIST/HIP KEYS SCORE SPORT Activity Factor VII (%) Page 3 of 5
4 B. Attached below are the beta coefficients from the Cox regression models for the basic models presented in the referenced paper. We also add the values of (1) S 0. = 1 P 0 = Probability of no incident CHD event within 10 years for a person with the reference (zero) level of the categorical exposure variables and the median level of the continuous exposure variables (medians for SBP are 119, for newage -0.1 at this value of newage 2 was 0.01) and (2) 1000 RS 0, where RS 0 is the value of the risk score (sum of probabilities or exposure x both coefficients) for persons at levels at which S 0 is calculated. Predicted 10 year risk, P, for a person with risk score RS is then calculated as 1-P = (1-P o ) exp (RS-RS 0), under a proportional hazards assumption. Black Females NEWAGE NEWAGE tccat TCCAT HDLCAT hdlcat HDLCAT SBP (mmhg) HYPT MEDS DIABETES CUR SMK0KING Black Males 1 - P RS NEWAGE NEWAGE TCCAT TCCAT TCCAT HDLCAT hdlcat HDLCAT SBP HYPT MEDS DIABTS CUR SMK0KING P RS Page 4 of 5
5 White Females NEWAGE NEWAGE TCCAT TCCAT TCCAT HDLCAT hdlcat HDLCAT SBP HYPT MEDS DIABTS CUR SMK0KING White Males 1 - P RS NEWAGE NEWAGE TCCAT tccat HDLCAT HDLCAT HDLCAT HDLCAT SBP HYPT MEDS DIABTS CUR SMK0KING P RS Page 5 of 5
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