Physical exercise as prophylaxis against involutional vertebral bone loss: a controlled trial
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1 Clinical Science (1 983) 64, Physical exercise as prophylaxis against involutional vertebral bone loss: a controlled trial BJPIRN KRPILNER, BIRTE TOFT, STIG PORS NIELSEN AND ERIK TPINDEVOLD Department of Medicine F, Department of Rheumatology, Department of Clinical Physiology and Department of Orthopaedic Surgery, Frederiksborg County Hospital, Hiller&, Denmark (Received 4 January/8 October 1982; accepted 23 November 1982) Summary 1. The skeletal effects of physical training were studied in a controlled trial involving 31 healthy women (aged years) with previous Colles fracture of the forearm. The bone mineral content of the lumbar spine and both distal forearms was measured by dual-photon (ls3gd) absorptiometry. 2. The participants were allocated to either a physical exercise group or a control group. The former group followed a standardized exercise programme, exercising for 1 h twice weekly during 8 months. 3. Twenty-seven women completed the study. Lumbar spine bone mineral content of the exercise group increased by 3.5%, whereas that of the control group decreased by 2.7%. The rate of bone loss in the control group equalled that of age-matched normal women. 4. The changes in forearm bone mineral content appeared to be independent of the exercise. The bone mineral content of the previously fractured forearm remained nearly unchanged. The bone mineral content of the uninjured forearm decreased on average by 3.5%. 5. The data suggest that physical exercise can inhibit or reverse the involutional bone loss from the lumbar vertebrae in normal women. Physical exercise may prevent spinal osteoporosis. Key words: bone mineral content, fractures, osteoporosis, physical exercise, prophylaxis, spine. Correspondence: Dr B. Krcalner, Department of Medicine F, Frederiksborg County Hospital, DK Hillerd, Denmark. Introduction The crush fractures of spinal osteoporosis are incurable. A rational treatment of osteoporosis implies prevention of the bone loss that leads to structural deterioration of the vertebral bodies ill. Physical activity is a major determinant of bone remodelling and bone mass 121, and physical exercise has been suggested as a possible prophylactic against involutional bone loss and osteoporosis [3,41. The main purpose of the present study was to investigate whether physical exercise could prevent the involutional bone loss from the lumbar vertebrae in healthy women. Material and methods Patients Thirty-one otherwise healthy women (aged years) with previous fractures of the distal forearm (Colles fracture) consented to participate in this prospective trial in accordance with the Helsinki I1 Declaration. The patients comprised about half the middle-aged women treated for Colles fracture in the emergency ward of the hospital during 1979 [4]. The risk of future vertebral compression fractures in those patients was considered to be somewhat higher than the risk in age-matched normal woman [4, 51. The times elapsing after the forearm injury were 9-21 months. The study was conducted from September 1980 till May Protocol The participants were allocated to either a physical exercise group (n = 16) or a control group (n = 15). Randomization was impractic The Biochemical Society and the Medical Research Society
2 542 B. Krkllner et al. TABLE 1. Initial values in the two groups studied Abbreviations: BPP, blood pressure-pulse rate product at submaximal work load; BMC, bone mineral content. Variable Physical exercise Controls (n = 16) (n= IS) Mean SD Mean SD Age (years) Years after the menopause Time after the forearm injury (months) Body height (cm) Body weight (kg) Maximal oxygen uptake (I/min) lo-' BPP (mmhg beats) Lumbar spine BMC (units) Forearm BMC (units/cm) Serum calcium (normalized) (mmol/l) Serum phosphate (mmol/l) Serum alkaline phosphatase (units/l)* Serum albumin (mmolll) I I I Laboratory normal range: unitsh. able owing to difficulties of patient transport. Those living close to the hospital were included in the exercise group. Those living far from the hospital were controls. Table 1 shows the initial values of relevant biological variables in the two groups. The patients were maintained on their usual diets. Calcium supplements were not given. All medical treatment (hypnotics, analgesics, diuretics) was continued. Three women were still premenopausal or perimenopausal (all in the control group). Three received oestrogens (two in the exercise group, one in the control group). Oestrogen had been administered for more than 5 years in each case. Exercise programme The women in the exercise group exercised for 1 h twice weekly during 8 months under the supervision of an experienced physiotherapist. The training load was considered to be moderate for that age group. The programme included: (1) walking exercises, (2) running exercises, (3) exercises in standing, (4) exercises in sitting, (5) exercises in lying, (6) exercises on all fours and (7) ball games. Each training period was initiated with warming-up exercises for 5 min. Any sparing of the fractured arm was omitted, but the training programme did not focus on training of the forearms separately. The women were encouraged to continue exercising at home. An amplified version of the exercise programme is available from the authors on request. Compliance to the trial Three women left the exercise group during the first 2 months, the reasons being lack of time, fatigue and backache respectively. The last of the three showed symptoms and signs of a prolapsed intervertebral disc. One woman had a peritendinitis of short duration. No other medical complications related to the exercising were observed. The rate of attendance at the single training periods ranged from 39 to 100% (mean 73%) in the 13 women who completed the entire exercise programme. One woman left the control group for personal reasons. Methods A standard bicycle ergometer test was utilized for prediction of the maximal oxygen uptake during work. Changes in the systolic blood pressure-pulse rate product at submaximal work load were used as a measure of the conditioning effect of the exercise programme. Maximal oxygen uptake and blood pressurepulse rate product were not calculated in two patients treated for mild hypertension (one in each group), one treated for atrial fibrillation (in the control group) and one with knee complaints (in the control group). Bone mineral content of the lumbar spine and both distal forearms was measured by dualphoton ( ls3gd) absorptiometry as previously described [4, 6, 71. Lumbar bone mineral content was expressed as the total mineral mass of the second, thud and fourth lumbar vertebrae in arbitrary units (dimension: mass). Forearm bone
3 mineral content was expressed as the average mineral density of a 1.0 cm segment of both distal forearms in units/cm (dimension: mass per unit length). The forearm measuring site was at least 1.5 cm proximal to the fracture line of the previous Colles' fracture, and callus was not measured. Serum concentrations of calcium, inorganic phosphate, total alkaline phosphatase and albumin were determined by routine methods. All serum samples were kept deep-frozen and analysed during 1 day. Serum calcium concentration was normalized to a serum albumin concentration of 0.70 mmol/l. The variables were determined before the beginning of the trial and after 4 and 8 months. Statistical evaluation Student's t-test for paired and unpaired samples was used for comparison. P values less than 0.05 were considered significant. Calculations were based on differences between initial and 8 months' values. Results are given as means f SEM. Results The exercise group and the control group were comparable with regard to age, duration of menopause, time elapsing after the forearm injury, physical performance capacity and mineral metabolism before the beginning of the trial (Table 1). Prevention of bone loss by exercise 543 The training programme was an obvious social success. The exercise group showed an 11.3% decrease in the blood pressure-pulse rate product at submaximal work load after 8 months (P < 0-Ol), whereas the control group showed a non-significant decrease of 4.7%. Effects on bone mineral content are summarized in Figs, 1 and 2. The mean change in lumbar bone mineral content in the exercise group was an increase of 1.3 f 0.6 units or 3.5 f 1.6% (not significant, N.S.; P ) compared with a decrease of 1.2 f 0.5 units or 2.7 k 1.3% (P < 0.05) in the control group (Fig. 1). The difference between these changes was highly significant (2.5 f 0.8 units, P < 0-005). The spinal bone mineral loss in the control group equalled that of 32 age-matched normal women [71. Forearm bone mineral content remained practically unchanged in the exercise group, whereas a reduction of 0.05 f 0.02 unit/cm or 3.7 f 1.8% (P < 0.05) was seen in the control group (Fig. 1). The difference between the groups was not statistically significant (P ). Analyses of bone mineral content of the uninjured and the fractured forearm separately indicated a pattern of differential bone mineral changes, independent of physical exercise (Fig. 2). When the data of both groups of women (n = 27) were pooled the uninjured forearm showed a mean decrease of 0.05 f 0.02 unit/cm or 3.5 k 1.6% (P < 0-Ol), whereas the fractured forearm showed a mean increase of unit/cm or 1.8 f 1.7% (N.S.). 5; * a w c) 5 * g g z 4J 0- n 0 2 n E C.I D 2= m (a) V I I I I I 1 September January May September January Mav Time (months) FIG. 1. Lumbar spine (a) and forearm (b) bone mineral contents (BMC) before and during exercising. a+, Exercise group; 0...O, control group. Values are given as the mean deviation (+ SEM) from the values before the beginning of the trial (September). **Significantly different from the control group (P < 0.01).
4 544 B. Krdner et al. lbl T I I I 1 I I September January May September January Mav Time (months) FIG. 2. Bone mineral content (BMC) of the uninjured forearm (a) and fractured forearm (b) before and during exercising. a+, Exercise group; , control group. Values are given as the mean deviation (+ SEM) from the values before the beginning of the trial (September). The difference obtained between the changes in the bone mineral content of the uninjured and the fractured forearm (0.07 f 0.03 unit/cm) approximated to the mean differences of 0.10 f 0.02 unitlcm between bone mineral contents of the uninjured and the fractured forearm in the patients before the trial (i.e. the fracture-related bone loss 141). All biochemical variables remained unchanged during the study. The results were not changed if the premenopausal women and the women receiving oestrogens were excluded. Discussion The etiology of primary (involutional) osteoporosis is multifactorial [8, 91. Oestrogen deficiency is considered as one main cause of net bone resorption in postmenopausal women [ 101, other possible factors being insufficient dietary calcium intake [ 111, impaired renal conversion of 25-hydroxycholecalciferol into 1,25-dihydroxycholecalciferol (leading to diminished intestinal calcium absorption) 112, 131 and osteoblast failure [14]. The influence of altered mechanical loading of the skeleton in aging women might be an additional factor of great importance [l, 41. Skeletal muscle mass and muscle strength decline with increasing age [151 and involutional bone loss might reflect an adaptive response to decreased physical activity. The bone loss that occurs after immobilization [ 161 and the apparent bone mass gain of athletes 171 need no emphasis. It follows from the hypothesis that decreasing mechanical stimulation with increasing age is an important pathogenetic factor in osteoporosis, that the involutional bone loss might be reversed by physical training [ll. The present trial supports this hypothesis. Our results suggest that physical exercise can inhibit the involutional bone loss from the axial skeleton in middle-aged women and lead to net gain in axial bone mass. The effects of exercise on forearm bone mineral content were not significant. This might be due to a differential exercise response in trabecular and cortical bone. Nevertheless, the groups studied were too small to exclude the possibility of parallel changes in the axial and the appendicular skeleton, and forearm exercises being more rigorous than in the present training programme might be beneficial. Smith et al have demonstrated a 2% increase in forearm bone mineral content of aged women after a programme of physical exercise for 3 years. Aloia et al. [31 found a similar effect on total body calcium in normal women immediately after the menopause. It is a matter of controversy whether the bone loss that follows Colles fractures in adults is reversible [ 19, 201. Our previous cross-sectional
5 Prevention of bone loss by exercise 545 results [41 suggested total reversal of the fracturerelated bone loss within 3 years after the injury. The present longitudinal study confirms this finding. However, it appears that the reversal is due to acceleration of the normal involutional bone loss in the uninjured forearm rather than net bone mass gain in the fractured limb. It is as yet unclear whether the systematic decrease in bone mineral content seen in January (Figs. 1 and 2) indicates a midwinter diminution of bone mineralization or bone mass Administration of oestrogens or calcium supplements to normal postmenopausal women tends to inhibit or partly reverse the involutional bone loss [22-261, whereas administration of vitamin D metabolites [271 and fluorides [281 might prevent bone loss in a subgroup of older women with obvious spinal osteoporosis. These agents are associated with significant risks, however, and treatment will be tentative since it remains to be established that the susceptibility to vertebral fractures is lowered by the therapy [25, 261. Physical exercise appears to be an appropriate alternative. The medical side-effects of physical exercise are less serious, and exercising may in addition strengthen the musculo-ligamental support of the spine and improve the general physical performance and well-being. Motivation for long-term prophylaxis is essential for successful prevention of spinal osteoporosis. The social aspects of exercising in groups could be an effective way to encourage middleaged women to take exercise necessary to decrease the risk of vertebral fractures. Further studies are needed to establish the long-term effects and side-effects of physical exercise on the involutional bone loss in different parts of the skeleton. Acknowledgments The exercise programme was kindly conducted by Mrs K. Ibsen and Mrs N. Mercier, leading physiotherapists. The technical assistance of Mrs A. Hytholm is acknowledged. The study was supported by a grant from Nordisk Gjenforsikrings Selskabs Jubilseumsfond. References 111 RADIN, E.L. (1981) Mechanical aspects of fractures and their treatment. In: Osteoporosis. Recent Advances in Pathogenesis and Treafment, pp Ed. DeLuca, H.F., Frost, H.M., Jee, W.S.S., Johnston, C.C. & Pa&, A.M. University Park Press, Baltimore. 121 LANYON, L.E. (198 1) Bone remodelling, mechanical stress and osteoporosis. In: Osfeoparosls, Recenf Advances in Pathogenesis and Treatment, pp Ed. DeLuca, H.F., Frost, H.M., Jee, W.S.S., Johnston, C.C. & Pdtt, A.M. University Park Press, Baltimore. 131 ALOIA, J.F., Corn, S.H., OSTUNI, J.A., CANE, R. & ELLIS, K. (1978) Prevention of bone loss by exercise. Annals of Internal Medlcine, KRBLNER, B., TBNDEVOLD, E., TOPT, B., BERTHELSEN, B. & Pons NIeLsEN, S. (1982) Bone mass of the axial and appendicular skeleton in women with Colles fracture. Its relation to physical activity. Clinical Physiology, 2, GAY, J.D. (1974) Radial fracture as an indicator of osteoporosis: a 10-year follow-up study. Canadian Medical Association Journal, 111, KRBLNER, B. & Pons NleLSEN, S. (1980) Measurement of bone mmeral content (BMC) of the lumbar spine. I. Theory and application of a new two-dimensional dual-photon attenuation method. Scandinavian Journal of Clinical and Laboratory Investigation, KRBLNER, B. & Pons NIELSEN, S. (1982) Bone mineral content of the lumbar spine in normal and ostcoporotic women: cross-sectional and longitudinal studies. Clinlcal Science, 62, NORDIN, B.E.C., PEACOCK, M., CRILLY, R.G., FRANCIS, R.M., SPEED, R. & BARKWORTH, S. (1981) Summation of risk factors in osteoporosis. In: Osfeoparosis, Recent Advances in Pathogenesis and Treatment, pp Ed. DeLuca, H.F., Frost, H.M., Jee, W.S.S., Johnston, C.C. & Parfitt, A.M. University Park Press, Baltimore. 191 RIOOS, B.L. (1981) Osteoporosis-a disease of impaired homeostatic regulation. Mineral and Elecfrolyte Mefabollsm, 5, HEANEY, R.P. (1965) A unified concept of osteoporosis. American Journal of Medlcine, 39, Ill] HEANEY, R.P., RECKER, R.R. & SAVILLE, P.D. (1977) Calcium balance and calcium requirements in middle-aged women. American Journal of Clinical Nulrltion, 30, GALLAOHER, J.C., RIOOS, B.L., EISMAN, J., HAMSTRA, A., ARNAUD, S.B. & DeLucA, H.F. (1979) Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients. Effect of age and dietary calcium. Journal of Clinical Invesfigation, 64, SLOVIK, D.M., ADAMS, J.S., NEE& R.M., Houc~, M.F. & Pons, J.T., Jn (1981) Deficient production of 1,25dhydroxy vitamin D in elderly osteoporotic patients. New England Journal of Medicine, 305, I141 PAMITT, A.M., MATHEWS, C., RAO, D., FRAME, B., WeeneKoPen, M. & VILLANUEVA, A.R. (1981) Impaired osteoblast function in metabolic bone disease. In: Osteoparosfs, Recent Advances in Pathogenesis and Treafment, pp Ed. DeLuca, H.F., Frost, H.M., Jee, W.S.S., Johnston, C.C. & ParRtt, A.M. University Park Press, Baltimore Done, F., BROWN, J. & LACHANCE, C. (1970) Relation between bone mass and muscle weight. Lancef, 1, NILSSON, B.E. (1966) Post-traumatic osteopenia. A quantitative study of the bone mineral mass in the femur following fracture of the tibia in man using americum-241 as a photon source. Acta Orthopaedica Scandinavica, Suppl NILSSON, B.E. & WESTLIN, N.E. (1971) Bone density in athletes. Clinical Orthopaedics and Related Research, 77, SMITH, E.L., REDDAN, W. & Shtrm, P.E. (1981) Physical activity and calcium modalities for bone mineral increase in aged women. Medicine and Science in Sports and Exercise, 13, WESTLIN, N.E. (1974) Loss of bone mineral after Colles fracture. Clinical Orfhopaedics and Relafed Research, 20, NILSSON, B.E. & Wem, N.E. (1975) Long-term observations on the loss of bone mineral following Colles fracture. Acta Orthopaedica Scandinavlca, I211 KRBLNER, B. (1983) Seasonal variation of lumbar spine bone mineral content in normal women. Calcged i Yssue International, 35. (In press) LINDSAY, R., HART, D.M., AIIKBN, J.M., MACDONALD, E.B., ANDERSON, J.B. & CLARKE, A.C. (1976) Long-term prevention of postmenopausal osteoporosis by oestrogen. Lancet, I, HORSMAN, A., GALLAOH~R, J.C., SWSON, M. & NORDIN, B.E.C. (1977) Prospective trial of oestrogen and calcium in postmenopausal women. British Medical Journal,
6 ~ _._ 546 B. Krdner et al REEKER, R.R., SAVILLE, P.D. & HEANEY, R.P. (1977) Effect of oestrogens and calcium carbonate on bone loss in 1271 GALLAGHER, J.C., RIGOS, B.L. & DELUCA, H.F. (1981) Effects of calcitrol in osteoporosis. In: Osteoporosis, Recent postmenopausal women. Annals of Internal Medicine, 87, Aduances in Pathogenesis and Treatment, pp Ed DeLuca, H.F., Frost, H.M., Jee, W.S.S., Johnston, C.C. & 1251 HUTCHINSON, T.A., POLANSKY, S.M. & FEINSTEIN, A.R. Parfitt, A.M. University Park Press, Baltimore. (1979) Postmenopausal oestrogens protect against fractures of 1281 BRIANCoN, D.1 VIONON, E., ARLOT, M. hip and distal radius. Lancet, I, CHARHON, S. (1981) Effects of combined therapy with sodium fluoride-vitamin D-calcium on vertebral fracture risk. and 1261 MATHOVIk, V., KOSTIAL, K., SIMONIVI~, I., BUZINA, R., bone histology in osteoporosis. In: Osteoporosis. Recent BROOAREC, A. & NORDIN, B.E.C. (1979) Bone status and Advances in Pathogenesis and Treatment, pp Ed. fracture rates in two regions of Yugoslavia. American Journal DeLuca, H.F., Frost, A.M., Jee, W.S.S., Johnston, C.C. & of Clinical Nutrition, 32, Parfitt, A.M. University Park Press, Baltimore.
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