Evidence in focus Compendium of evidence
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1 Evidence in focus Compendium of evidence Summary of the current preclinical and clinical evidence on NAVIO NAVIO Supporting healthcare Supporting healthcare professionals for over 150 years Surgical System Supporting healthcare professionals
2 Evidence in focus Compendium of evidence NAVIO Surgical System Purpose Key: Study outcomes Key: Study type To summarise the current preclinical and clinical evidence on NAVIO (Smith & Nephew Memphis, TN, USA). 20 studies reporting on NAVIO Patient outcomes Total operative time Clinical study Preclinical study Studies Study outcomes Study type Page number Why robotics? Conventional techniques vs robotics 4 NAVIO Surgical System design 4 Robotic-assisted unicompartmental knee replacement with NAVIO surgical system: Outcome evaluation using knee injury osteoarthritis outcome score 5 Early survivorship of robotic-assisted unicompartmental knee arthroplasty 5 Preliminary results of UKR implanted using an image free handheld robotic device 6 Case study: totals aren t always an inevitability 6 Case study: first in man: using the NAVIO surgical system to implant a JOURNEY UNI knee 7 Improved joint-line restitution in unicompartmental knee arthroplasty using a robotic-assisted surgical technique 7 of imageless robotically assisted unicondylar knee arthroplasty 8 The learning curve of a novel handheld robotic system for unicondylar knee arthroplasty 8 Handheld precision sculpting tool for unicondylar knee arthroplasty. A clinical review 9 page 2 of 16
3 Studies Title Study outcomes Study type Page number Implant orientation accuracy of a hand-held robotic partial knee replacement system over conventional technique in a cadaveric test 10 High degree of accuracy of a novel image-free handheld robot for unicondylar knee arthroplasty in a cadaveric study 10 of a freehand sculpting tool for unicondylar knee replacement 11 assessment of a novel image-free handheld robot for Knee Arthroplasty in bi-cruciate retaining knee and total knee replacement a cadaveric study 11 assessment of a novel image-free handheld robot for knee arthroplasty in bi-cruciate retaining total knee replacement 12 A novel image-free handheld robot for bi-cruciate retaining knee arthroplasty 12 validation of semi-active robotic application for patellofemoral arthroplasty 13 The accuracy of a robotically-controlled freehand sculpting tool for unicondylar knee arthroplasty 13 NAVIO PFS for unicondylar knee replacement: early cadaver validation 14 Precision freehand sculpting for unicondylar knee replacement: design and experimental validation 14 The learning curve of robotically-assisted unicondylar knee arthroplasty 15 References and abbreviations 165 page 3 of 16
4 Why robotics? Conventional techniques vs robotics Conventional Manual instruments include alignment rods that are intra- or extra-medullary that centralize and align the components according to the surgical plan. 1 Conventional alignment guides: Lack precision 1-2 Are not tailored to each patient s individual morphology Can result in inadvertent deviations from the surgical plan 2 Robotics Robotic systems include passive, semi-active, and active systems with a robotic arm, robotic guided cutting jigs, and robotic milling systems. For total and partial knee replacement, robotic systems may: Help surgeons avoid surgical errors 1, 3 Decrease variability 3 Increase accuracy in mechanical alignment for more natural kinematics 3-6 The current literature demonstrates that using computer navigation for UKA [compared to conventional techniques] results in better limb alignment and component positioning 2 NAVIO Surgical System design NAVIO is an image-free, freehand sculpting semi-active robotic tool, that allows for intraoperative patient-specific planning The NAVIO system has two types of robotic control modes, Exposure Control and Speed Control. The surgeon can alternate between these two cutting control modes. Exposure Control Exposure Control adjusts the bur s exposure with respect to a guard. If the surgeon encroaches on a portion of bone that is not to be cut, the NAVIO Surgical System retracts the spinning bur behind the guard, disabling cutting. The NAVIO Surgical System software adjusts the depth of the cut by adjusting the exposure of the bur outside of the guard. During Exposure Control, the bur spins at full power (80,000 rpm), regardless of exposure level. Speed Control Speed Control regulates the speed of the bur, from 0 to 80,000 rpm, depending on its position. The control mode limits the speed of the spinning bur or disables bur motion entirely if the target surface has been reached. Bur motion is also disabled if the bur is moved outside of planned cutting boundaries. The NAVIO handpiece accurately removes bone identified by the surgeon approved, patient-specific plan page 4 of 16
5 Robotic-assisted unicompartmental knee replacement with NAVIO surgical system: outcome evaluation using knee injury osteoarthritis outcome score 7 Vega Parra P, et al. Rev Chil Ortop Traumatol. 2017;58:7-12. Patient outcomes Single-centre case series of 47 patients operated on with NAVIO using the STRIDE UNI prosthesis 80 pre-uka post-uka KOOS recorded at 12 months post-uka Statistically significant increase in all categories of KOOS at post-uka compared to pre-uka (p<0.05) Mean KOOS score Symptoms Pain Daily activity Sports and recreational activities Quality of life NAVIO robotics-assisted UKA with STRIDE UNI demonstrated a substantial improvement in patients quality of life, reducing pain and improving function during sports and recreational activities. Early survivorship of robotic-assisted unicompartmental knee arthroplasty 8 Battenberg A, et al. 35th Annual Meeting of SOA. July 11-14, 2018; Palm Beach, FL, USA. Patient outcomes Retrospective study to assess revision rates of patients who received UKA with NAVIO 128 UKA patients included who had undergone UKA with NAVIO at five US sites Surgeon adopter s initial cases Mean follow up of 2.3 years Survivorship at 2 years with NAVIO: 99.2% Australian registry Swedish registry New Zealand registry NAVIO Greater than that reported in the Australian, New Zealand and Swedish registry One revision with NAVIO Due to hamstring irritation and ischial tuberosity bursitis in 60 year old male % 96.3% 96% 99.2% Survivorship data from this study compared to annual registry data for conventional UKA reporting 2-year UKA survivorship High early implant survivorship rate for the NAVIO system that is higher than that presented in the literature for annual registries. page 5 of 16
6 Preliminary results of UKR implanted using an image free handheld robotic device 9 Gonzalez D, et al. BASK Annual Meeting. 8-9 April, 2014; Norwich, UK. Patient outcomes A single surgeon performed unicondylar knee replacement (UKR) on 18 patients with NAVIO Surgical System, OKS (old) improved from 38 pre-uka to 23 six weeks post-uka (22 to 37 new OKS, respectively) Oxford knee score (new) Six week-post-operative results Pre-UKR Six weeks post-ukr Preliminary analysis shows satisfactory post-ukr outcome for UKR with NAVIO. Case study: totals aren t always an inevitability 10 Gregori A, et al. BLUE BELT Technologies Inc Patient outcomes Active, 53 year old male Satisfied with prior partial knee procedure in right knee, now severe pain in medial compartment with no lateral/anterior compartment pain in left knee Surgeon exploring partial knee replacement as first option but considering total due to extreme varus deformity of 12 At the planning stage, NAVIO allowed the surgeon to make an informed decision intraoperatively on best way to proceed NAVIO allowed the surgeon to plan an implant fit and position with minimal bone resection to balance knee and correct long leg alignment without over-correction Post-operative long leg alignment 2º varus (improvement of 10º) Pre-operative Post-operative NAVIO allows surgeons to confidently approach a challenging surgery with the knowledge that they can execute a predetermined plan accurately to get the best outcome for the patient. page 6 of 16
7 Case study: first in man: using the NAVIO surgical system to implant a JOURNEY UNI knee 11 Gregori A, et al. BLUE BELT Technologies Inc Patient outcomes 67 year old male with left knee osteoarthiritis Pain predominantly on medial side of knee Pre-operative deformity of 8 varus, medial compartmental cartilage thinning and joint space narrowing Previous right knee unicompartmental knee replacement (UKR) Planned post-ukr alignment = 2 of varus Achieved post-ukr alignment = 3 The surgeon increased planned insert thickness during surgery, as NAVIO is a flexible platform Surgical time from tracker placement to trial acceptance: 50 minutes Total cutting time: 20 minutes Both patient and surgeon satisfied Patient discharged two days post-ukr with >90 knee flexion Post-operative frontal view Post-operative sagittal view Improved joint-line restitution in unicompartmental knee arthroplasty using a robotic-assisted surgical technique 12 Herry Y, et al. Int Orthop. 2017;41: Retrospective study comparing joint-line height following UKA using: NAVIO robotics-assisted technique (40 patients) NAVIO Conventional Conventional technique (40 patients) Weight bearing radiographs taken pre-uka and two months post-uka Two validated radiologic measurement methods used to assess joint-line height The joint-line was distalised significantly more in the conventional group than in the NAVIO (p<0.05) Mean joint-line height difference after surgery (mm) p<0.05 p< Method 1 Method 2 NAVIO robotics-assisted UKA allows for intraoperative planning of implant position and accurate bone resection, resulting in improved joint-line restitution when compared with a conventional technique. Furthermore, NAVIO Surgical System may avoid creating femoral superstructures, thereby reducing excessive tibial resection which may help to prevent pain and other post-uka complications. page 7 of 16
8 of imageless robotically assisted unicondylar knee arthroplasty 13 Gregori A, et al. 15th Annual meeting of CAOS. June 17-20, 2015; Vancouver, Canada. Authors prospectively collected radiographic data on 92 patients who underwent medial UKA with NAVIO Surgical System at four centres (four surgeons) 89% of patients had post-uka alignment within 3 of the planned coronal mechanical axis alignment Post-UKA alignment within 3 of the planned coronal mechanical axis alignment RMS error 1.98 RMS error between plan and post-uka radiographic implant position: Femoral tibial alignment: 2.6 Tibial coronal alignment: 2.9 Tibial slope: % Use of NAVIO can accurately prepare the bone surface of the tibia and femur which allows for few errors resulting in high levels of accuracy in the planned coronal mechanical axis alignment, when comparing planned versus achieved component placement. The learning curve of a novel handheld robotic system for unicondylar knee arthroplasty 14 Wallace D, et al. Bone Joint J. 2014;96B:SUPP16. Total operative time Five surgeons performed unicondylar knee arthroplasty (UKA) on at least 15 patients with NAVIO Two surgeons had experience with robotic devices for UKA All surgeons had experience with conventional UKA All surgeons had experience with navigation for other knee procedures The number of surgeries to reach steady state surgical time was calculated as the point in which two consecutive cases were completed within the 95% confidence interval of the surgeon s steady state time Average surgical time for the first 15 cases was 56.8 minutes Average improvement from slowest to quickest surgical time was 46 minutes Average of eight procedures to steady state 50 min average steady state surgical time Average steady state surgical time was 50 minutes NAVIO has a comparable learning curve to other robotics-assisted devices on the market. page 8 of 16
9 Handheld precision sculpting tool for unicondylar knee arthroplasty. A clinical review 15 Gregori A, et al. 15 th EFORT Congress. June 4-6, 2014; London, UK. Patient outcomes Total operative time Clinical review Evaluation of the clinical and functional outcomes of the first 57 patients undergoing UKA with NAVIO Surgical System Post-UKA mechanical axis alignment within 1 of intra-operative NAVIO plan in 91% of cases UKA reduced mean mechanical axis deformity from -6.2 pre-uka to -3.4 six weeks post-uka Mean NAVIO time (from tracker placement to implant trial acceptance) decreased from 69 to 54 minutes Cutting phase time decreased by 32.5 minutes from first to quickest procedure Mean Oxford Knee Score showed clinical improvement from 22 pre-uka to 36 six weeks post-uka All patients achieved full extension post-uka Cases within 1 of intra-operative plan Post-UKA mechanical axis alignment NAVIO allows surgeons to repeatedly precisely plan and accurately execute UKA. The learning curve of NAVIO is reduced following a small number of cases. page 9 of 16
10 Implant orientation accuracy of a hand-held robotic partial knee replacement system over conventional technique in a cadaveric test 16 Khare R, et al. Computer Assisted Surgery. 2018;23:8-13. Two surgeons each carried out medial bilateral UKA on six cadavers Equal number of UKAs were carried out with NAVIO Surgical System used on one knee and conventional methods for the other knee Conical divots were prepared at known positions on the implants to allow for accuracy assessment CT scans were obtained pre and post-uka to identify final implant position, which was then compared to the planned position 8 NAVIO Conventional Maximum RMS femoral implant orientation error: NAVIO = <2.81 Conventional = <7.52 Maximum RMS tibia implant orientation error: NAVIO = <2.96 Conventional = <4.06 Maximum RMS implant orientation error ( ) Femoral Tibial NAVIO provides improved implant alignment accuracy over conventional approaches to UKA. High degree of accuracy of a novel image-free handheld robot for unicondylar knee arthroplasty in a cadaveric study 17 Lonner JH, et al. Clin Orthop Relat Res. 2015;473: Four individuals carried out medial UKA on 25 cadavers with NAVIO Planned implant orientation and actual implant orientation were compared Bone preparation and implant position were within the range of 0.8 to 1.3mm and 1 to 2 of the planned implant position Error (degree/mm*) Femoral component accuracy (deg) (mm) Error (degree/mm*) Tibial component accuracy (deg) (mm) 0.0 Angular Transitional 0.0 Angular Transitional *Figures show degree/mm absolute means errors across three planes NAVIO provides accurate implementation of the surgical plan, with low levels of error, and is comparable to other semi-autonomous robotic orthopaedic devices. page 10 of 16
11 of a freehand sculpting tool for unicondylar knee replacement 18 Smith JR, et al. Int J Med Robotics Comput Assist Surg. 2013;10: A single surgeon tested precision of NAVIO Surgical System Carried out UKA with 20 identical femur and tibia synthetic bone pairs Four fidicular markers drilled in each femur and tibia sawbones were used to measure pre- and post-uka position Fibicular marker analysis: Minimal movement of the arrays Mean cut surface data: Slight undercut of 0.14mm for femur and 0.21mm for tibia All implant positions compared favourably to the plan and were within the expected target zone with low errors in rotational and translational placement Transitional error (mm) Rotational error (degree) Component placement accuracy (translational errors) 0.42 Femur Tibia 0.32 Planned v achieved rotation Femur Tibia NAVIO implant positions are accurate to plan, with low levels of error in rotational and translational placement. assessment of a novel image-free handheld robot for knee arthroplasty in bi-cruciate retaining knee and total knee replacement a cadaveric study 19 Mitra R. 2nd World Arthroplasty Congress April, Rome, Italy. Nine surgeons carried out TKA with NAVIO using a variety of implant types on: 32 cadaveric femurs 34 cadaveric tibia Final implant position was measured and compared to the surgical plan using a position tracking camera and analysis software Error type Total error Femoral Varus/valgus Distal resection (femoral)/resection depth (tibial) 0.85mm 1.0mm Rotation (femoral)/posterior slope (tibial) NAVIO achieves accurate implementation of the surgical plan with low levels of error. Tibial page 11 of 16
12 assessment of a novel image-free handheld robot for knee arthroplasty in bi-cruciate retaining total knee replacement 20 Jaramaz B, et al. EPiC Health Sciences. 2018;2: The study compared the planned and final implant placement using the JOURNEY II XR bi-cruciate retaining knee implant with NAVIO Surgical System TKA was performed on 24 cadaveric femurs, eight synthetic femurs, two cadaveric tibias, 10 synthetic tibias Final implant position was measured and compared to the surgical plan using a separate position tracking camera and analysis software A quantitative analysis was performed to determine the translational, angular, and rotational differences between the planned and achieved positions of the implant Error type Mean RMS error Femoral implant Tibial implant Varus/valgus Rotation (femoral)/posterior slope (tibial) Distal resection 0.86mm 0.68mm NAVIO allows for accurate implementation of the planned procedure for JOURNEY II XR placement. A novel image-free handheld robot for bi-cruciate retaining knee arthroplasty 21 Jaramaz B, et al. 19 th EFORT Congress. May 30-June 1, 2018; Barcelona, Spain. NAVIO was used for TKA using a bi-cruciate retaining device on 32 cadaveric femurs, two cadaveric tibias and ten synthetic tibial bones Position tracking camera analysis software was used to compare planned and final implant position Type of RMS error Mean total error Femoral Varus/valgus Rotation (femoral)/posterior slope (tibial) Distal resection (femoral)/resection depth (tibial) 0.85mm 0.68mm Tibial Optimal implant planning can replicate the joint line, and achieve balanced range of motion outcome, specific to each patient s need. page 12 of 16
13 validation of semi-active robotic application for patellofemoral arthroplasty 22 Jaramaz B, et al. 15th Annual meeting of CAOS. June 17-20, 2015; Vancouver, Canada. Tests were performed (n=24) for four different implant designs, with a minimum of five cases per implant design NAVIO surgery was simulated with four implant designs (two inlay and two onlay ) Minimum of three synthetic bones and two cadavers were used for each design Fiducial markers establish a reference frame to determine the accuracy of prosthesis placement Final implant position and planned position were compared Error type Mean total error Maximum RMS error 0.87mm Maximum rotational error 1.2 NAVIO accuracy is in accordance with those previously reported for UKR surgery. The accuracy of a robotically-controlled freehand sculpting tool for unicondylar knee arthroplasty 23 Smith JR, et al. Congress of ISB. 4-9 August, Natal, Brazil Two users trained with NAVIO, performed UKA on nine cadavers Consultant orthopaedic surgeon performed four implants Research associate performed five implants 3D image of the actual implant position was overlaid on the planned implant image to quantify differences in planned and achieved cuts In three planes and three rotations Error type Mean total error Femoral Maximum implant rotational error Maximum implant translational error 2.6mm 2.7mm Maximum RMS angular error RMS translational error across all directions 1.1mm 2.0mm Tibial NAVIO offers optimal positioning and sizing of implants, and the freehand sculpting tool produces accurate implant placement low errors. page 13 of 16
14 NAVIO PFS for unicondylar knee replacement: early cadaver validation 24 Jaramaz B, et al. 13th Annual meeting CAOS. June 13-15, 2013; Orlando, FL, USA. Three operators performed medial UKR surgery with NAVIO Surgical System on two cadaver specimens (four knees) Each component included a set of eight conical divots in predetermined locations to allow for measurement of the position All NAVIO-assisted implants were within 1.5mm of the target in all directions Error type Mean total error Maximum translation error 1.31mm Maximum rotational error (femoral) 1.90 Maximum rotational error (tibial) 3.26 RMS error over all components 0.69mm/1.23 Use of NAVIO shows high levels of accuracy comparable to other robotics-assisted devices. Precision freehand sculpting for unicondylar knee replacement: design and experimental validation 25 Jaramaz B & Nikou C. Biomed Tech. 2012;57: Total operative time Evaluation of NAVIO performance for UKR in terms of implant fit and cutting time Three users with different levels of experience Five sawbone specimens Total cutting time: 6.5 to 9.5 minutes Component placement accuracy Bone preparation time Mean cut time: 8.01 minutes Average distance from the planned implant position was 0.54mm Average total error: 0.54mm/1.08 Placement error (degree/mm) Rotational 0.54 Translational Time (minutes) :16 8:14 User 1 User 2 Range + Mean 7:40 User 3 NAVIO achieves high levels of accuracy, adequate for joint replacement surgery, with low levels of error. page 14 of 16
15 The learning curve of robotically-assisted unicondylar knee arthroplasty 26 Simons M & Riches P. Bone Joint J. 2014;96B:SUPP Total operative time Five junior orthopaedic trainees all underwent initial NAVIO Surgical System UKA training and performed five UKAs with NAVIO on left-sided synthetic femurs and tibiae Each procedure was video recorded and timed A ballpoint probe with four reflective spherical markers attached was used to record the position of prepared divots on the implant to allow the 3D position of the implant to be compared to the planned position Total surgical time decreased significantly from 85 to 48 minutes after five surgeries All stages, except cutting tool set up, demonstrated a significant difference in operative time with increasing number of surgeries performed (p<0.05) Cutting phase decreased from 41 to 23 minutes Translational and rotational accuracy of the implants did not significantly vary with surgery number 44% reduction in operative time after five surgeries Adequate accuracy was achieved from the first surgery The learning curve of the protocol and technology suggests a 44% reduction in the operation time after five surgeries is realistic. page 15 of 16
16 References 1. Pastides P, Nathwani D. The role of newer technologies in knee arthroplasty. Orthopaedics and Trauma. 2017;31: Nair R, Tripathy G, Deysine GR. Computer navigation systems in unicompartmental knee arthroplasty: a systematic review. Am J Orthop. 2014;43: Jacofsky DJ, Allen M. Robotics in Arthroplasty: A Comprehensive Review. J Arthroplasty. 2016;31: Lonner JH. Robotically Assisted Unicompartmental Knee Arthroplasty with a Handheld Image-Free Sculpting Tool. Orthop Clin North Am. 2016;47: Roche M. Robotic-assisted Unicompartmental Knee Arthroplasty. The MAKO Experience. Orthop Clin North Am. 2015;46: Lonner JH, Moretti VM. The Evolution of Image-Free Robotic Assistance in Unicompartmental Knee Arthroplasty. Am J Orthop. 2016;45: Vega Parra PD, Dionisio Palacios Barajas J, Marquez Ambrosi RA, Duarte JR. Robotic-assisted unicompartmental knee replacement with NAVIO surigical system: Outcome evaluation using knee injury osteoarthritis outcome score. Rev Chil Ortop Traumatol. 2017;58: Battenberg A, Netravali NA, Lonner JH. Early Survivorship of Robotic-Assisted Unicompartmental Knee Arthroplasty. Poster presented at: Southern Orthopaedic Association 35 th Annual Meeting; July 11-14, Palm Beach; Florida, USA. 9. Gonzalez D, Deakin AH, Picard F. Preliminary results of UKR implanted using an image free handheld robotic device. Poster presented at: Annual Meeting of the British Association for Surgery of the Knee; 8-9 April, 2014; Norwich, UK. 10. Gregori A, Lethbridge R, Simone A. Case study: totals aren t always an inevitability. BLUE BELT Technologies Inc Gregori A, Smith J, Simone A. Case study: First in man: using the NAVIO surgical system to implant a JOURNEY UNI knee. BLUE BELT Technologies Inc Herry Y, Batailler C, Lording T, Servien E, Neyret P, Lustig S. Improved joint-line restitution in unicompartmental knee arthroplasty using a robotic-assisted surgical technique. Int Orthop. 2017;41: Gregori A, Picard F, Lonner J, Smith J, Jaramaz B. of imageless robotically assisted unicondylar knee arthroplasty. Paper presented at: International Society for Computer Assisted Orthopaedic Surgery; June 17-20, 2015; Vancover, Canada. 14. Wallace D, Gregori A, Picard F, Bellemans J, Lonner J, Marquez R, Smith J, Simone A, Jaramaz B. Bone Joint J. 2014;96B:SUPP Gregori A, Picard F, Bellemans J, Smith J, Simone A. Handheld precision sculpting tool for unicondylar knee arthroplasty. A clinical review. Abstract presented at: 15 th EFORT Congress; June 4-6, 2014; London, UK. 16. Khare R, Jaramaz B, Hamlin B, Urish KL. Implant orientation accuracy of a hand-held robotic partial knee replacement system over conventional technique in a cadaveric test. Computer Assisted Surgery. 2018;23: Lonner JH, Smith JR, Picard F, Hamlin B, Rowe PJ, Riches PE. High degree of accuracy of a novel image-free handheld robot for unicondylar knee arthroplasty in a cadaveric study. Clin Orthop Relat Res. 2015;473: Smith JR, Riches PE, Rowe PJ. of a freehand sculpting tool for unicondylar knee replacement. Int J Med Robot. 2014;10: Mitra R. Assessment of a Novel Image-Free Handheld Robot for Knee Arthroplasty in Bi-Cruciate Retaining Knee and Total Knee Replacement A Cadaveric Study. Abstract presented at: World Arthroplasty Congress; April 19-21, 2018; Rome, Italy. 20. Jaramaz B, Mitra R, Nikou C, Kung C. Technique and Assessment of a Novel Image-Free Handheld Robot for knee Arthroplasty in Bi-Cruiciate Retaining Total Knee Replacement. EPiC Series in Health Sciences. 2018;2: Jaramaz B, Mitra R, Rovinsky D, Neginhal V. A Novel Image-Free Handheld Robot For Bi-Cruciate Retaining Knee Arthroplasty. Poster presented at: 19 th EFFORT Annual Congress; May 30- June 1, 2018; Barcelona, Spain. 22. Jaramaz B, Noickou C, Casper M, Grosse S, Mitra R. validation of semi-active robotic application for patellofemoral arthroplasty. Paper presented at: International Society for Computer Assisted Orthopaedic Surgery; June 17-20, 2015; Vancover, Canada. 23. Smith JR, Picard F, Lonner J, Hamlin B, Rowe P, Riches P, Deakin A. The accuracy of a robotically-controlled freehand sculpting tool for unicondylar knee arthroplasty. Congress of the International Society of Biomechanics. 4-9 August, Natal, Brazil. 24. Jaramaz B, Nikou C, Simone A. NAVIO PFS for unicondylar knee replacement: early cadaver validation. Abstract presented at: International Society for Computer Assisted Orthopaedic Surgery; June 12-15, 2013; Florida, USA. 25. Jaramaz B, Nikou C. Precision freehand sculpting for unicondylar knee replacement: design and experimental validation. Biomed Tech (Berl). 2012;57: Simons M, Riches P. The learning curve of robotically-assisted unicondylar knee arthroplasty. Bone Joint J. 2014;96B:SUPP Abbreviations UKA: unicondylar knee arthroplasty KOOS: knee injury and osteoarthritis score OKS: Oxford knee score TKA: total knee arthroplasty RMS: Root mean square Disclaimer Great care has been taken to maintain the accuracy of the information contained in the publication. However, neither Smith & Nephew, nor the authors can be held responsible for errors or any consequences arising from the use of the information contained in this publication. The statements or opinions contained in editorials and articles in this journal are solely those of the authors thereof and not of Smith & Nephew. The products, procedures, and therapies described are only to be applied by certified and trained medical professionals in environments specially designed for such procedures. No suggested test or procedure should be carried out unless, in the reader s professional judgment, its risk is justified. Because of rapid advances in the medical sciences, we recommend that independent verification of diagnosis, drugs dosages, and operating methods should be made before any action is taken. Although all advertising material is expected to conform to ethical (medical) standards, inclusion in this publication does not constitute a guarantee or endorsement of the quality or value of such product or of the claims made of it by its manufacturer. Some of the products, names, instruments, treatments, logos, designs, etc. referred to in this journal are also protected by patents and trademarks or by other intellectual property protection laws even though specific reference to this fact is not always made in the text. Therefore, the appearance of a name, instrument, etc. without designation as proprietary is not to be construed as a representation by the publisher that it is in the public domain. This publication, including all parts thereof, is legally protected by copyright. Any use, exploitation or commercialisation outside the narrow limits of copyrights legislation, without the publisher s consent, is illegal and liable to prosecution. This applies in particular to photostat reproduction, copying, scanning or duplication of any kind, translating, preparation of microfilms and electronic data processing and storage. Institutions subscriptions allow to reproduce tables of content or prepare lists of articles including abstracts for internal circulation within the institutions concerned. Permission of the publisher is required for resale or distribution outside the institutions. Permission of the publisher is required for all other derivative works, including compilations and translations. Permission of the publisher is required to store or use electronically any material contained in this journal, including any article or part of an article. For inquiries contact the publisher at the address indicated US-en V1 09/18. Published September 2018, 2018 Smith & Nephew. Smith & Nephew, Inc, 1450 Brooks Road, Memphis, TN 38116, USA Trademark of Smith & Nephew. All rights reserved. page 16 of 16
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