Hiroto Yamaguchi*, Hidetoshi Nojiri**, Kei Miyagawa*, Nozomu Inoue***

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1 Three-Dimensional High-Resolution Image Analysis of the Segmental Reduction Effect Obtained with Lateral Lumbar Interbody Fusion for Lumbar Intervertebral Deformity Hiroto Yamaguchi*, Hidetoshi Nojiri**, Kei Miyagawa*, Nozomu Inoue*** *Dept of Orthopedic Surgery, Juntendo Tokyo Koto Geriatric Center, Tokyo, Japan ** Dept of Orthopedic Surgery, Juntendo University, Tokyo, Japan ***Dept of Orthopedic Surgery, Rush University, Chicago, USA EuroSpine 2018, September, Barcelona, Spain

2 Back ground Increase in elderly population Increase of treatment opportunities for degenerative lumbar scoliosis (DLS) cases There is no unified view on therapy for DLS In recent years, extreme lateral interbody fusion (XLIF) has been performed and its utility is being studied The detailed correction mechanism of XLIF is not clear

3 Purpose & Subjects Evaluating the effect of correcting intervertebral deformity by inserting an XLIF cage Measuring spinal morphology during XLIF 28 subjects with lumbar degenerative disease (14 subjects with L3/4 and 14 with L4/5, respectively) XLIF was performed to relieve the neuropathy (e.g., pain, gait disturbance) at our institution from June 2014 to July 2016 Patients with intentional correction from the posterior side and adult spinal deformity cases were excluded

4 Methods CT DICOM data( preoperatively and 3 months after surgery) Export Point cloud data Segmentation using MimicsR software In-house developed analysis routines

5 Consideration item 1Euler angle Preoperative alignment Local coordinates were set for each posterior wall of the vertebral body not affected by vertebral degeneration Postoperative alignment

6 Consideration item 2Disc height 1Each Euler angle Wedge angle, Axial rotation angle (not be distinguished from each other) Kyphosis angle (+:kyphosis, -:lordosis) 2Disc height (mm) Measurement Values of preoperatively and postoperatively The perioperative amount of change The perioperative correction rate Their correlation

7 Results The mean values of the targeted 28 vertebrae Wedge angle -4.6 (p<0.001) Leveling Kyphosis angle (p=0.017) Lordorsis mm 9.3mm Axial rotation angle -2.1 (p=0.004) Reduct rotation Disc height +3.92mm (p<0.001)

8 AXIAL ROTATION ANGLE Results correlation A positive correlation was found between wedge angles and axial rotation angles (r = 0.62, P <0.001) Perioperative correlation WEDGE ANGLE No significant correlation was found between wedge / kyphosis / axial rotation angles and disc height

9 Discussion A significant correlation was found between wedge angles and axial rotation angles regarding the perioperative amount of change (P<0.001) Indicating that correction of the intervertebral wedge deformity by cage insertion also corrected the rotational deformity Coupling reduction effect

10 Discussion There was no significant correlation between the disc height and the wedge/axial rotation angle The amount of correction of the wedge/axial rotation angle did not depend on the amount of change in the disc height It is not necessary to forcibly insert an implant with a high cage height, risking vertebral body end-plate damage A low cage A high cage Dangerous? There is no difference in the amount of correction. It depended solely on the leveling of the intervertebral space?

11 Discussion correction effect of LLIF Ligamentotaxis effect of both the intervertebral ligament such as ALL, PLL and the remaining annulus fibrosus Annulus fibrosus The intervertebral space is lifted The torsion of annulus fibrosus and intervertebral ligament is corrected by tension Axial rotation angle is corrected Thickness reduced site = relax Thickness increased site = tension*1 1)Yang B, et al (Biomech Model Mechanobiol)

12 Conclusion The effect of correcting intervertebral deformity by quantifying 3D-CT images using a means to measure accurately the perioperative form during LLIF was validated. Leveling the intervertebral wedge deformity by cage insertion also corrected rotational deformity. Ligamentotaxis could partially achieve intervertebral correction of both wedge and rotation deformities without forcibly inserting a large cage during LLIF. Authors disclosure statement: The authors report no actual or potential conflict of interest in relation to this article.

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