INTERNATIONAL SYMPOSIUM ON LIGAMENTS & TENDONS-XIV PRELIMINARY PROGRAM

Transcription

1 INTERNATIONAL SYMPOSIUM ON LIGAMENTS & TENDONS-XIV PRELIMINARY PROGRAM 7:00 AM Registration and Light Breakfast 8:00 AM Welcome Savio L-Y. Woo, Ph.D. Helen H. Lu, Ph.D. 8:15 AM Clinical Talk Kai-Ming Chan, M.D., Ph.D. Podium Session 1: Enthesis 8:30 AM Keynote Lecture: William Levine, M.D. 8:40 AM 8:45 AM 8:50 AM 8:55 AM Indian Hedgehog Signaling in Tendon-Bone Healing: A Potential Regulator of Enthesis Repair Enthesis Mineral Apposition During Postnatal Growth and Following Joint Destabilization in the Adult Insertion Fibrochondrocyte Growth and Biosynthesis on Nanofiber Scaffolds Engineering and Characterizing Nanofibrous Composite Scaffolds with Spatially-Varying Architecture Andrew Carbone Nathaniel Dyment Dovina Qu David Corr 9:00 AM Discussion 9:15 AM 9:20 AM 9:25 AM 9:30 AM Multiple-Techniques to Evaluate the Fibrous Interzone During the Bone-Tendon Junction Healing for Anterior Cruciate Ligament Reconstruction (ACLR) Model in Rabbits Gradient Polyurethane Scaffolds for Improved Regeneration of the Tendon Enthesis Ageing, Deep Venous Thrombosis and Male Gender Impair Outcome After Achilles Tendon Rupture Silk Scaffold with Osteoconductive and Osteoinductive Cues for Enthesis Regeneration in Anterior Cruciate Ligament Reconstruction Jiali Wang Tyler Touchet Paul Ackermann Thomas Teh 9:35 AM Discussion

2 9:50 AM 10:00 AM 10:05 AM 10:10 AM Podium Session 2: Tissue Engineering Keynote Lecture: Mahmut Nedim Doral, M.D. Endoscopy and Percutaneous Suturing in the Achilles Tendon Ruptures and the Importance of Paratenon A Novel Magnesium Ring for Regeneration of an Injured ACL In Vitro and In Vivo Studies in Goats Fabrication of Multi-Layered Tendon Tissue Engineering Scaffold Consisting of Electrospun Nanofibers and Photocrosslinked Hydrogel In Vivo Evaluation of a Bioresorbable PLLA Device for Regeneration of the ACL Katie Farraro Guang Yang William Walsh 10:15 AM Discussion 10:25 AM 10:30 AM 10:35 AM Platelet Based Blood Products for Stimulation of Tendon Healing: An In Vitro Cell Culture Study Biaxially Aligned Tendon-Derived Matrix-Poly(ε-Caprolactone) (PCL) Electrospun Scaffolds for Rotator Cuff Tendon Tissue Engineering A Novel Murine Model of Autograft Anterior Cruciate Ligament Reconstruction. Tanja Schmidt Dianne Little Carmilla Carballo 10:40 AM Discussion 10:50 AM Break/ Poster Session 11:20 AM 11:30 AM 11:35 AM Podium Session 3: Biology & Biomechanics Keynote Lecture: Zong-Ming Li, Ph.D. Biomechanics of the Transverse Carpal Ligament The Interfascicular Matrix Enables Fascicle Sliding and Recoil in Tendon, and Behaves More Elastically in Energy Storing Tendons 3-D Reconstruction of Intact and Stress Deprived Rat Tail Tendon Cells Chavaunne Thorpe Monika Egerbacher 11:40 AM The Role of p38 MAPK in Tendon Growth and Remodeling Kristoffer Sugg 11:45 AM Discussion

3 12:00 PM 12:05 PM 12:10 PM Early Embryonic Tendon Possesses an Actin Cytoskeleton Network with Crimp Full-Field Methods for Anterior Cruciate and Other Ligament Biomechanical Characterization New Biomechanical Testing Standards for Evaluating Adjustable Femoralcortical Suspension Devices Nathaniel Schiele Ellen Arruda Alexander Peterson 12:15 PM Discussion 12:30 PM 1:30 PM Group Photo and Lunch (Flash Presentations by Poster Presenters) Clinical Panel: Frontiers in Tendon/Ligament Research and Translation Podium Session 4: Tendinopathy 1:50 PM Keynote Lecture: James Wang, Ph.D. Aberrant Differentiation of Tendon Stem Cells Causes Tendinopathy 2:00 PM The Role of NF-κβ Signaling in Rotator Cuff Tendinopathy Shivam Shah 2:05 PM Cathepsin Activity in Human and Rat Supraspinatus Tendinopathy Akia Parks 2:10 PM Disruption of TGFβ Signaling in the Scleraxis Cell Lineage Leads to Tenocyte Dedifferentiation and Tendon Degeneration Guak-Kim Tan 2:15 PM Discussion 2:25 PM 2:30 PM Inhibition of HIF-2α Signaling with Digoxin Decreases Calcification in Tendinopathy Is NOD1 Activation Involved in Tendinopathy? Characterization on Clinical Samples and In Vitro Studies of NOD1 Activation on Cultured Tendon Cells Jiajie Hu Chelsea Hopkins 2:35 PM MicroRNA in Tendinopathy: A Translational Target Neal Millar 2:40 PM Discussion

4 2:50 PM 2:55 PM 3:00 PM 3:05 PM Does Hypoxia Contribute to Tendinopathy? Evidence From an In Vivo Murine Model Low-Dose Hydrogen Peroxide Impaired Tendon Healing And Induced Tendinopathic Changes Shear-Tension Ratio Effect on Healthy and Tendinopathic Human Tenocyte Metabolism. Pathological Tendon Properties: Stiffness, Strength and Proteoglycans Katie Trella Man-Yi Yeung Hazel Screen Rachel Choi 3:10 PM Discussion 3:25 PM Break/ Poster Session Podium Session 5: Rotator Cuff 3:55 PM Keynote Lecture: Ranjan Gupta, M.D. 4:05 PM 4:10 PM 4:15 PM 4:20 PM Matrix Metalloproteases and Tissue Inhibitors of Metalloproteases in Tenocytes of the Rotator Cuff Differ with Varying Donor Characteristics Genetic Response of Rat Supraspinatus Tendon and Muscle to Exercise Effect of Bone Mineral Density on Rotator Cuff Tear: An Osteoporotic Rabbit Model Biomechanical Role of Capsular Continuity in Superior Capsule Reconstruction for Irreparable Rotator Cuff Tears Franka Klatte-Schulz Sarah Rooney Hugo Giambini Teruhisa Mihata 4:25 PM Discussion 4:40 PM 4:45 PM 4:50 PM Optimum Tension for the Bridging Sutures in Trans-Osseous Equivalent Rotator Cuff Repair Non-Genetic Fabrication of a Novel Tendon-Derived Stem Cell (TDSC) Sheet for the Biological Repair of Rotator Cuff Tear Ultrasound-Guided Dry Needling on Healthy Rat Supraspinatus Tendon Joo Han Oh Jian-kun Xu Corinne Riggin 4:55 PM Discussion

5 5:05 PM 5:10 PM 5:15 PM Podium Session 6: Tissue Engineering and Stem Cells Stepwise Differentiation of Human Induced Pluripotent Stem Cells for Achilles Tendon Regeneration by Change of Physical Substrate Multiple Omics Analysis Reveals Age-Related Changes in Tendon Differentiation from Mesenchymal Stem Cells An Irradiation-and-Injection Approach to Study TSC Differentiation in Mice Can Zhang Mandy Peffers Jianying Zhang 5:20 PM Discussion 5:30 PM Closing Remarks Stavros Thomopoulos, Ph.D. 6:30 PM Reception/Dinner and Award Ceremony Joyful House Cuisine

6 Posters Direct Functional Mobilization After Achilles Tendon Rupture Promotes Early Healing Response A Multicenter Randomized Clinical Trial of an Immunochemically Modified Porcine Xenograft vs. Patellar Tendon Allograft for ACL Reconstruction Histological Evaluation of the Equine Superficial Digital Flexor Tendon (SDFT) During Ageing. A Hyperelastic Fibre-Reinforced Continuum Model of Healing Tendon with Distributed Collagen Fibre Orientations Transplantation of Fetal Instead of Adult Fibroblasts Display Intrinsic Differences in Tendon Regeneration and Reduce the Probability of Ectopic Ossification A Novel Magnesium Based Suture Anchor for Soft Tissue Fixation Morphologic Change of Gluteus Maximus and Medius After Harvesting Fascia Lata: Quantitative Evaluation by Magnetic Resonance Imaging Autologous Tenocyte Injection (ATI) for Gluteal Tendinopathy: A Pilot Study Investigating a Mouse Model of Collagenase-Induced Tendinopathy Differential Matrix Turnover of the Interfascicular Matrix of Tendons at Different Risk of Injury Development of a Novel Murine Achilles Tendon Explant System Generation and Characterization of an Immortalized Human Tendon Internal Fibroblast Cell Line Outcomes Following Revision Rotator Cuff Repair with Concentrated Bone Evidence of Long Term Durability of Autologous Tenocyte Injection (ATI) for Treatment of Chronic Lateral Epicondylitis Manufacture of Scaffold-Free Tendon in an Ex Vivo Tissue- Engineered System A New Approach to Enhance Tendon-Bone Junction Healing by Regenerating Fibrocartilage Zone Physical-Inductive Scaffolds for Bone and Tendon Regeneration by Regulating Lineage Specific Differentiation of MSCs Paul Ackermann Paul Ackermann Othman Ali M.N. Bajuri Xiao Chen Jonquil Flowers Yasuo Itami Greg Janes Jason Shearn Karen Sanders Katie Trella Jon Volmer Andreas Voss Allan Wang Tao Wang Jianying Zhang Zi Yin