Preliminary Program. Podium Presentations. Time Topic Speaker. 8:00 Welcome Hongwei Ouyang, M.D., Ph.D. Savio L-Y. Woo, Ph.D., D.Sc., D.

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1 Preliminary Program Podium Presentations Time Topic Speaker 7:30 Registration and Light Breakfast 8:00 Welcome Hongwei Ouyang, M.D., Ph.D. Savio L-Y. Woo, Ph.D., D.Sc., D.Eng 8:15 Clinical Keynote Lecture Re-recognition of Synthetics Ligament for ACL Reconstruction: Chinese Experience Shiyi Chen, M.D., Ph.D 8:25 Discussion Podium Session I: Tendon & Ligament Biomechanics Keynote Lecture 8:30 Orientation, Size and Function of the Anterior Cruciate Ligament During Skeletal Growth: Results From a Porcine Model 8:40 Discussion Shiyi Chen, M.D., Ph.D. Matthew Fisher, Ph.D. Matthew Fisher, Ph.D. 8:45 8:50 8:55 Biomechanical Augmentation of Tendon Graft Healing in Anterior Cruciate Ligament Reconstruction Using a Silk Based Osteoconductive Sheath Development of Functional Assessments by Gait and Open Field Analysis in a Rat Model of Rotator Cuff Tendon Repair MRI Measurement on Water Content in Patellar Tendon: Relationship with Tendon Integrity and Stiffness Thomas Teh, Ph.D. Yang Liu, M.Surg. Siu Ngor Fu, Ph.D. 9:00 9:05 Finite Element Analysis of Joint Stability and ACL Load Following Mechanical Augmentation for Goat ACL Healing Anterior Cruciate Ligament Reconstruction Revision Preoperative Planning, Intra Operative Findings and Postoperative Analysis Huizhi Wang, B.S. Christos D. Papageorgiou, M.D., Ph.D 9:10 Discussion 9:25 Coffee Break/Poster Session I (#1-12)

2 9:55 10:00 10:05 10:10 Podium Session II: Tendon & Ligament Biology Apoptotic Bodies From Tenocytes Enhance the Proliferation and Migration of Tenocytes and Bone Marrow Stromal Cells in a Canine Tendon In Vitro Model TGFβ1 Induces a Contractile CD146 + Phenotype of Human Annulus Fibrosus Cells Showing Affinity to a Collagen Gel Neural Crest-Derived Cells Migrate From Nerve and Participate in Achilles Tendon Remodeling Impaired Function of Tendon-Derived Stem Cells Isolated From Patellar Tendon in Streptozotocin-Induced Type I Diabetes Mellitus Rat Model: Implications for the Cellular Mechanism of the Diabetic Tendon Disorder Albert J. Banes, Ph.D. Minghao Zheng, M.D., Ph.D. Chenhui Dong, Ph.D., M.D. Zhen Li, Ph.D. Kang Xu, Ph.D. Shi Liu, M.D., M.S. 10:15 Discussion 10:30 Anatomical Heterogeneity of Canine Digit Annular Ligament Yu-Long Sun, Ph.D. 10:35 10:40 Toxicity of Tranexamic Acid to Human Tendon Tissue and Tenocytes In Vitro mir-378 Inhibits Extracellular Matrix Production During Tendon Repair in Mouse Model Michael McLean, MbChb, Bmsc Yang Liu, Ph.D. 10:45 Discussion 11:00 Podium Session III: ACL and Tendon-to-Bone Healing I Keynote Lecture Current Strategy in the Treatment of Tendinopathy Kai-Ming Chan, M.D., Ph.D. Kanglai Tang, M.D., Ph.D. Kanglai Tang, M.D., Ph.D. 11:10 A Novel KGN-Releasing Polymer for Regeneration of Wounded Tendon-Bone Junction Jianying Zhang, Ph.D. 11:15 11:20 11:25 Autologous Adipose-Derived Mesenchymal Stem Cells-Sheets Sandwiched by a Book-Type Acellular Fibrocartilaginous Matrix Scaffold Enhances Tendon-Bone Healing Flexible Bipolar Nanofibrous Membranes for Improving Gradient Microstructure in Tendon-to-Bone Healing Tendon Stem Cells Transduced with SOX9 Improve Tendon-to Bone Healing in a Rat Model Can Chen, B.S. Xiaoxi Li, B.S. Youxing Shi, Ph.D.

3 11:30 Discussion 11:45 Effect of PET Graft Coated with Silk Fibroin via EDC/NHS Crosslink on Graft-Bone Healing in ACL Reconstruction Dandan Sheng, M.Med. 11:50 The Effect of 58S Bioactive Glass Coating on Polyethylene Terephthalates in Graft-Bone Healing Yang Wu, M.D. 11:55 Development of Artificial Collagen Ligament (ACL ) for Anterior Cruciate Ligament Reconstruction Minghao Zheng, M.D., Ph.D. 12:00 Discussion 12:15 Lunch (Group Photo and Poster Viewing) 13:30 Podium Session IV: Tendon Repair and Regeneration Keynote Lecture Biological and Functional Treatment of the PCL Injury James Goh, Ph.D. Yu-long Sun, Ph.D. Ramon Cugat, M.D., Ph.D. 13:40 Discussion 13:45 Savio L-Y. Woo Young Researcher Award Biology Research Category Novel Tendon-Derived Stem Cell Sheet Secures Functional Repair of Torn Rotator Cuff Through TGF-β3 and IGF-1 Signaling 13:55 Discussion Jiankun Xu, Ph.D. 14:00 Thermo-Responsive Elastomer Layers for Cell Sheet Engineering with Dynamic Cell Culture In Vitro Gen Wang, Ph.D. 14:05 3D Printed Knitted Scaffold for Tunable Delivery of mir210 for Tendon Regeneration Yanjie Zhang, B.S. 14:10 Discussion 14:20 14:25 Gelatin-Grafted Poly(L-lactide) Electrospun Fibrous Membranes for Healing Improvement After Rotator Cuff Repair The Mechanical Property and Microstructure of Scaffolds Regulate Differentiation of Annulus Fibrosus-Derived Stem Cells Wenguo Cui, Ph.D. Genglei Chu, Ph.D.

4 14:30 The Effect of Bone Marrow Stem Cells-Seeded Polyethylene Terephthalate Scaffold on Repair and Regeneration of Rabbit Achilles Tendon Jiangyu Cai, Ph.D. 14:35 Discussion Podium Session V: Tendon-Related Stem Cell Biology Sai Chuen Bruma Fu, Ph.D. Yiting Zhou, Ph.D. 14:50 14:55 15:00 15:05 Stem Cells Isolated From Sheath and Core of Rabbit Anterior Cruciate Ligament (ACL) Exhibit Differential Biological Properties Tenogenic Differentiation of Human Mesenchymal Stem Cells on Highly Aligned Ultrafine PLLA Fibers Functionalized by Type-I Collagen and Chondroitin Sulfate 3D Microenvironments Boost Induction of Stemness and Tenogenesis in TSPCs Through RNA Demethylation Curcumin Maintains the Phenotype and Promote the Tenogenesis of Tendon Stem/Progenitor Cells in the Pathological Microenvironment of Tendinopathy Biao Chen, M.D., Ph.D. Huihua Yuan, Ph.D. Qin Tian, B.S. Zi Yin, Ph.D. 15:10 Discussion 15:25 15:30 15:35 Phenotypic Expansion of Mouse Tendon Stem/Progenitor Cells for Tendon Repair by Small Molecule Activation of AKT-mTOR Signaling Directs Tenogenesis of Mesenchymal Stem Cells Fos Promotes Tenogenic Differentiation of Tendon Stem/Progenitor Cells Can Zhang, Ph.D. Yiting Zhou, Ph.D. Jialin Chen, Ph.D. 15:40 Discussion 15:55 Coffee Break/Poster Session II (#13-23)

5 16:25 16:30 Podium Session VI: ACL and Tendon-to-Bone Healing II Surface Modification of VEGF Loaded Silk Fibroin to Improve Biological Performance of UHMWPE via Promoting Angiogenesis Intraoperative Irrigation with Magnesium and Vitamin C Solution Reduced Morphological Alterations in Quadriceps Muscle and Improved Graft Healing Following ACL Reconstruction in a Rat Model Chunfeng Zhao, M.D. Gang Li, M.D, Ph.D. Chengchong Ai, M.Med. Yau-Chuk Cheuk, M.Phil. 16:35 Local Delivery of Controlled-Release Simvastatin to Improve the Biocompatibility of Polyethylene Terephthalate Artificial Ligaments for Reconstruction of the Anterior Cruciate Ligament Peng Zhang, Ph.D. 16:40 Discussion 16:55 17:00 Ectopic Tissue Engineered Ligament with Silk Collagen Scaffold for ACL Regeneration The Use of Silk Fibroin Coating to Enhance Intra-Articular Ligamentization of PET Artificial Ligament in Beagle Dog ACL Reconstruction Model Jisheng Ran, M.D. Jia Jiang, M.D. 17:05 Comparison of the Allograft and Autograft After Anatomical Lateral Ankle Ligament Reconstruction Using MRI UTE-T2* Evaluation 17:10 Discussion Yinghui Hua, M.D., Ph.D. 17:25 The Mg Interference Screw Developed for Enhancement of the Tendon Graft Healing in ACL Reconstruction Model Jia-li Wang, Ph.D. 17:30 Effect of bfgf-loaded Ca 5 (PO 4 ) 2 SiO 4 Bioceramic on Tendonto-Bone Healing After Repair of Chronic Rotator Cuff Tear Song Zhao, M.D. 17:35 Discussion 17:45 Closing Remarks for ISL&T - XVII Hong-Wei Ouyang, M.D., Ph.D. Zong-Ming Li, Ph.D. 18:00 Meeting adjourned 19:00 Banquet and Award Ceremony Hangzhou The New Hotel

6 Poster Presentations Chih-Hwa Chen, M.D. Christos D. Papageorgiou, M.D., Ph.D. Hongbin Lu, Ph.D. Bin Li, Ph.D. Poster Number Title Presenter 1 2 Effects of Vitrification on the Biological Characteristics of Tendon Stem/Progenitor Cells in the Rat Tendon Tissues A Study on the Hierarchical Collagen Meshwork of Achilles Tendons Guang-Chun Dai, B.S. Jian-Ping Wu, Ph.D. 3 Injectable Microcryogel Cell Microcarriers for the Repair of Acute Achilles Tendon Rupture in a Rat Model. Xuan Yang Comparative Study of the Ability of Tendon Stem Cells and Bone- Marrow Stem Cells to Promote the Repair of the Tendon-Bone Interface Enhancement of Tendon Repair by Tendon-Derived Extracellular Matrix Membrane Bone Marrow Mesenchymal Stem Cells-Sheets Sandwiched by a Book-Shape Decellularized Tendon Matrix Scaffold for Repair of Achilles Tendon Defect The Effect of Cartilage Fragments on Tendon-Bone Integration After Anterior Cruciate Ligament Reconstruction: A Prospective Randomized Controlled Study Biological Augmentation of Tendon to Bone Healing Repair Using bfgf-loaded Electrospun PLGA Fibrous Membranes Biological Augmentation of Rotator Cuff Repair Using bfgf- Loaded Electrospun Poly(lactide-co-glycolide) Fibrous Membranes Achilles Tendon Adaptation During a 12-week Minimalist Running Retraining Inhibition of Rac1 Activity Prevents Pathological Calcification in Degenerative Tendinopathy Chengsong Yuan Meihan Tao, M.S. Hongbin Lu, Ph.D. Chi Zhang, Ph.D. Wei Su, M.D. Wenxiao Qi, B.S. Xini Zhang, M.S. Yangwu Chen, B.S. 12 Surface Modification of Polyethylene Terephthalate Ligament by Hydroxyapatite Plasma Spraying Improves Biocompatibility In Nitro and Osseointegration In Vivo Siheng Wang, M.D.

7 Poster Number Title Presenter 13 Regulation of Tendon-Derived Stem Cell Differentiation by the Degenerative Tendon Microenvironment Chang Liu, M.D. 14 Sparc Regulates Tendon Development Tao Wang, Ph.D Aligned Silk-Collagen Scaffold for Functional Massive Rotator Cuff Repair Microfluidic Chip System for Decellularized Tendon Based 3D- Biomimetic Scaffolds to Enhance the Bone-Tendon Interface Healing and Its Mechanism The Osteogenesis of Hydroxyapatite and Gelatin Coating on the Polyethylene Terephthalate Artificial Ligament Development of an Assay to Address Potency, Purity and Identity for Autologous Tenocyte Implantation Evaluation of the Bone-Ligament and Tendon Insertions Based on Raman Spectrum and Its PCA and CLS Analysis 3D Printed Scaffold with Delivery of TGF-β1 mirna Plasmid for Preventing Flexor Tendon Adhesion Formation Jiayun Huang, M.S. Jingtong Lyu, M.D., Ph.D. Dandan Sheng, M.Med. Minghao Zhang, M.D., Ph.D. Yang Wu, M.D. Yinxian Yu, M.D In vitro Evaluation of Rotator Cuff Repairment with Biocomposite Suture Anchor: Long-Term Degradation Study Decellularization of Remolded Rat Gracilis Muscle Flap as a Potential Scaffold for Skeletal Muscle Composite Allotransplantation Identification of an Anti-Inflammation Protein, Annexin A1, in TDSCs of Cystic Fibrosis Mice Xiao-Yan Cao, B.S. Chenhui Dong, Ph.D., M.D. Yang Liu, Ph.D.