3:30 PM 4:00 PM Hazel Screen, PhD, Queen Mary, University of London The Tendon Interfascicular Matrix Niche
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1 Discovery to Delivery in Tendon Research: Team Approaches ORS Tendon Section 2018 Conference November 15-17, 2018 Oregon Health and Science University, Portland, Oregon Conference Chairs: Ronen Schweitzer, PhD; Kathleen Derwin, PhD; Peter Amadio, MD; and Catherine K. Kuo, PhD Thursday, November 15, :00 AM 2:00 PM Registration 2:00 PM 2:15 PM Welcome and Meeting Goals 2:15 PM 3:15 PM Keynote Speaker: Lou Soslowsky, PhD, University of Pennsylvania Perspectives on the Field of Tendon Research and the Roles of Decorin and Bigylcan in Tendon Structure and Function 3:15 PM 3:30 PM Break 3:30 PM 7:00 PM Session I: Tendon Biology Chair: Hazel Screen, PhD, Queen Mary, University of London Moderator: Catherine K. Kuo, PhD, University of Rochester 3:30 PM 4:00 PM Hazel Screen, PhD, Queen Mary, University of London The Tendon Interfascicular Matrix Niche 4:00 PM 4:30 PM Catherine K. Kuo, PhD, University of Rochester Embryonically Inspired Tendon Regeneration Approaches 4:30 PM 4:45 PM Short Talk Nathaniel Disser, BS, Hospital for Special Surgery Insulin-like Growth Factor-1 Promotes Tenocyte Proliferation Through ERK1/2 Signal Transduction 4:45 PM 5:00 PM Short Talk Joohyun Lim, PhD, Baylor College of Medicine Loss of Fkbp10 in Murine Tendons and Ligaments Recapitulates Key Features of Bruck Syndrome 5:00 PM 5:30 PM Break
2 5:30 PM 6:00 PM Michael Kjaer, MD, DMSc, Copenhagen University Physiological Adaptation of Tendon Collagen to Exercise 6:00 PM 6:30 PM Alayna Loiselle, PhD, University of Rochester Defining Cell Lineage, Fate and Function to Inform Tendon Therapeutics 6:30 PM 6:45 PM Short Talk Anne E.C. Nichols, PhD, Virginia-Maryland Regional College of Veterinary Medicine Scleraxis Regulates Cytoskeletal Dynamics in Adult Tenocytes 6:45 PM 7:00 PM Short Talk Kenneth Weekes, BS, Oregon Health & Science University Temporomandibular Joint Articular Disc: Development Guided Regeneration 7:00 PM 9:00 PM Networking Dinner Friday, November 16, :00 AM 8:00 AM Networking Breakfast for Hyatt House Portland/Downtown Guests 8:30 AM 12:00 PM Session II: Tendon Development Chair: Jenna Galloway, PhD, Massachusetts General Hospital, Harvard Stem Cell Institute Moderator: Ronen Schweitzer, PhD, Shriners Hospital 8:30 AM 9:00 AM Jenna Galloway, PhD, Massachusetts General Hospital, Harvard Stem Cell Institute Exploring Tendon Developmental Plasticity and Regeneration in the Zebrafish 9:00 AM 9:30 AM Delphine Duprez, PhD, University Pierre et Marie Curie Mechanical and Molecular Signals Involved in Tendon Formation 9:30 AM 9:45 AM Short Talk Deepanwita Pal, PhD, Shriners Hospital for Children Multiple Roles of Scleraxis in Cell Recruitment and Collagen Organization at Distinct Stages of Tendon Growth 9:45 AM 10:00 AM Short Talk Dirk Hubmacher, PhD, Icahn School of Medicine at Mt. Sinai Absence of the Extracellular Matrix Protein ADAMTSL2, Mutated in Geleophysic Dysplasia, Results in Short Tendons and Reduced Bone Length 10:00 AM 10:30 AM Break 10:30 AM 11:00 AM Thomas Schilling, PhD, University of California Irvine Mechanotransduction Regulates Tenocyte-ECM Dynamics in Zebrafish 11:00 AM 11:30 AM Rui Diogo, Howard University Evolutionary Developmental Pathology, or Macroevolutionary Medicine: A New Field of Science Bringing Together Anatomy, Human Evolution, Development, Genetics, Birth Defects and Medicine
3 11:30 AM 11:45 AM Short Talk Rulang Jiang, PhD, Cincinnati Children's Hospital Medical Center Mkx-deficient Mice Exhibit Hedgehog Signaling Dependent Heterotopic Ossification in the Achilles Tendons 11:45 AM 12:00 PM Short Talk Hiroshi Asahara, MD, PhD, The Scripps Research Institute Mechano-signal Pathway Regulating Tendon and Ligament Via Mkx 12:00 PM -1:00 PM Networking Lunch 1:00 PM 3:00 PM Poster Session 3:00 PM 6:30 PM Session III: Tendon Injury and Repair Chair: Scott Rodeo, MD, Hospital of Special Surgery Moderator: Kathleen Derwin, PhD, Cleveland Clinic 3:00 PM 3:30 PM Chen-Ming Fan, PhD, Carnegie Science Molecular and Cellular Complexity of the Patellar Tendon Sheath 3:30 PM 3:45 PM Short Talk Guak-Kim Tan, PhD, Shriners Hospitals for Children TGF-beta Signaling is Essential for Cell Recruitment into Pathological Tendons 3:45 PM 4:15 PM Hani Awad, PhD, University of Rochester Differential Transcriptional Regulation in Models of Accelerated Tendon Repair 4:15 PM 4:30 PM Short Talk Franciele Dietrich-Zagonel, PhD, Linköping University Corticosteroid Treatment to Improve Achilles Tendon Healing is Dose and Time Dependent 4:30 PM 5:00 PM Break 5:00 PM 5:30 PM Scott Rodeo, MD, Hospital for Special Surgery Current Status of Cell-Based Therapies for Augmentation of Tendon Repair 5:30 PM 5:45 PM Short Talk Hua Shen, PhD, Washington University Anti-Inflammatory Effects of Stem Cell-Derived Extracellular Vesicles in the Early Phase of Tendon Healing 5:45 PM 6:00 PM Short Talk Jessica Ackerman, BS, University of Rochester Medical Center S100a4-lineage Cells Lose S100a4 Expression to Become Alpha-SMA+ Myofibroblasts During Scar-mediated Tendon Healing 6:00 PM 6:30 PM Brian Feeley, MD, University California San Francisco Stem Cells, Fat, and Muscle Changes after Rotator Cuff Injury and Repair
4 6:30 PM 8:30 PM Networking Dinner Saturday, November 17, :00 AM 8:00 AM Networking Breakfast for Hyatt House Portland/Downtown Guests 8:30 AM 12:00 PM Session IV: Biology and Pathology of the Enthesis Chair: Leesa Galatz, MD, Mount Sinai Health System Moderator: Kathleen Derwin, PhD, Cleveland Clinic 8:30 AM 9:00 AM Elazar Zelzer, Weizmann Institute of Science Enthesis Progenitors Combine the Tenogenic and Chondrogenic Genetic Programs 9:00 AM 9:15 AM Short Talk Amy Merrill, PhD, University of Southern California Pattering Cell Fate at the Interface between Tendon and Bone 9:15 AM 9:45 AM Steve Thomopoulos, PhD, Columbia University Tendon Enthesis Development and Regeneration 9:45 AM 10:00 AM Short Talk Marie-Therese Noedl, PhD, Massachusetts General Hospital Zebrafish as a Model of Tendon-Bone Attachment Injury and Regeneration 10:00 AM 10:30 AM Break 10:30 AM 11:00AM Xu Ca, PhD, Johns Hopkins University TGF-β in Skeletal Tissue Homeostasis and Enthesopathy 11:00 AM 11:15 AM Short Talk Keshia Mora, BS, University of Rochester Location-dependent Changes in Nuclear Morphology in the Achilles Tendon Due to Ankle Rotation 11:15 AM 11:30 AM Short Talk Eva Liu, MD, Brigham and Women's Hospital Impaired 1,25 Dihydroxyvitamin D Action Underlies Enthesopathy Development in Murine Hypophosphatemic Rickets 11:30 AM 12:00 PM Leesa Galatz, MD, Mount Sinai Health System Applying Translational Research to Rotator Cuff Repair: How Science Influences Practice 12:00 PM -1:00 PM Networking Lunch 1:00 PM 3:00 PM Poster Session 3:00 PM 6:30 PM Session V: Tendinopathy Chair: James Wang, PhD, University of Pittsburgh Moderator: Peter Amadio, MD, Mayo Clinic 3:00 PM 3:30 PM James Wang, PhD, University of Pittsburgh
5 The Role of HMGB1 in the Development of Tendinopathy 3:30 PM 4:00 PM Ashlee Watts, DVM, PhD, Texas A&M University Matrix Dysregulation in Tendinopathy 4:00 PM 4:15 PM Short Talk Adam Abraham, PhD, Columbia University IKKβ/NF-κB Activation Drives Rotator Cuff Tendinopathy 4:15 PM 4:30 PM Short Talk Zijun Zhang, PhD, MS, Colorado State University Expression of Estrogen Receptor and Accumulation of Advanced Glycation End-products in Tendinopathy 4:30 PM 5:00 PM Break 5:00 PM 5:30 PM Vincent Wang, PhD, Virginia Tech Assessment of Recombinant Human Hyaluronidase (rhuph20) as a Novel Therapeutic for Tendinopathy 5:30 PM 6:00 PM Andrew Carr, MDOS, University of Oxford Improving Evidence for Tendinopathy Therapies; the role of Randomized Clinical Trials 6:00 PM 6:15 PM Short Talk Mary Frances Barbe, PhD, Temple University Blocking CTGF/CCN2 Prevents Development of Fibrotic Tendon Changes and Motor Declines in a Rat Model of Repetitive Overuse Injury 6:15 PM 6:30 PM Short Talk Karin Gravare Silbernagel, PT, ATC, PhD Comparison of Tendon Structure, Symptoms, and Function in Patients with Either Midportion or Insertional Achilles Tendinopathy 6:30 PM 6:45 PM Awards and Closing Remarks 7:00 PM 9:00 PM Networking Dinner Thank you to the following conference supporters: Promoter Advocate
6 Supporter Friend `
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