GASTROINTESTINAL SYSTEM, METABOLISM AND RELATED DISORDERS

Transcription

1 Marmara University School of Medicine Y3C2 GASTROINTESTINAL SYSTEM, METABOLISM AND RELATED DISORDERS 27 October October 30, 2012-December 28, 2012

2 AIM At the end of this committee, third year students will gain knowledge about the development, structure and physiology of the gastrointestinal system and pathogenesis of the disorders related to this system. They will also gain knowledge about the signs and symptoms of gastrointestinal system disorders, related risk factors, prevention, diagnosis and principles of treatment. ENABLING OBJECTIVES: At the end of this committee, third year student will, understand and review the development, histology and structure of the gastrointestinal system, understand the working mechanism of gastrointestinal function and its regulation, comprehend gastrointestinal system as a processor converting foods to building stones of energy, define the pathologic processes in gastrointestinal system disorders, gain knowledge about microorganisms that affect the gastrointestinal system and its infections, gain knowledge about the risk factors related to gastrointestinal system disorders and preventive measures, gain knowledge about the major signs and symptoms of these disorders gain knowledge about the approach to diagnosis, and principles of treatment in gastrointestinal disorders comprehend laboratory investigation as a part of differential diagnosis. Suggested Readings: Biochemistry, Stryer, 4th Ed., Freeman Biochemistry, Zubay, 3rd Ed., WCB Harper's Biochemistry, Murray, Granner, 23rd Ed., Lange Interscience, New Jersey 2003 Introduction to Biostatistics For Health Sciences, Micheal R. Chernick, Robert H. Friss, Willey Lehninger Principles of Biochemistry, Nelson, Cox, 3rd edition, Worth Medical Statistics at a Glance, Aviva Petrie, Caroline Sabin, Blackwell Science, London, 2003 Physics, Giancoli, 4th Ed., Prentice Hall Practical Statistics For Medical Research, Douglas Altman, Chapman & Hall, London 1995 Principles of Physiology, Bern and Levy, 4th Ed. Temel Biyoistatistik, Mustafa Şenocak, Çağlayan Kitapevi, İstanbul 1990 Textbook of Physiology, Guyton and Hall, 10th Ed. The Cell: A Molecular Approach, Cooper, 2nd Ed., ASM Press Molecular Biology of the Cell, Alberts et al. 3rd Ed., Garland Basic Pathology (Stanley L. Robbins, Arcia Angel, Vinay Kumar) Color Textbook of Histology (Gartner, Hiatt) Developing Human (Moore) Histology and Cell Biology : An Introduction to Pathology (Abraham L. Kierszenbaum) Infectious Diseases (Bannistar, Begg, Gillespie) İnfeksiyon Hastalıkları ve Mikrobiyolojisi Cilt 1, 2 (Topçu, Söyletir, Doğanay) Tietr Textbook of Clinical Chemistry (Burtis, Ashwood) CURRENT Diagnosis & Treatment Gastroenterology, Hepatology, & Endoscopy, Second Edition 2012 (LANGE CURRENT Series) Norton Greenberger, Richard Blumberg, Robert Burakoff, Physiology of the Gastrointestinal Tract (Johnson, Alper, Christensen, Jacobson, Walsh)

3 Committee Coordinators Year 3 Coordinators Z. Arzu İLKİ, Associate Professor of Microbiology Chairperson of the Subject Committee Hakan AKIN, Associate Professor of Internal Medicine Gastroenterology Coordinators of Introduction to Clinical Practice Sibel KALAÇA,Associate Professor of Public Health Pemra ÜNALAN, AssociateProfessor of Family Medicine PBL Module Program Coordinator Neşe İmeryüz, Professor of Internal Medicine - Gastroenterology Departments Contributing to the Module Anatomy Biochemistry Biophysics Dentistry Family Medicine Gastroenterology General Surgery Histology and Embryology Microbiology Medical Biology Nuclear Medicine Pathology Pharmacology Pediatrics Pediatric Surgery Physiology Public Health Coaching in Laboratory Practicals Dilek AKAKIN, Specialist Dr., Histology and Embryology Burak AKSU, Instructor of Microbiology Betül ÇATALGÖZ, Assistant Professor of Biochemistry Ömer ÖZDOĞMUŞ, Associate Professor of Anatomy

4 Lecturers (in alphabetical order) Adnan GİRAL, Associate Professor of Internal Medicine - Gastroenterology Ahmet AKICI, Professor of Pharmacology Arzu UZUNER, Associate Professor of Family Medicine Atila KARAALP, Professor of Pharmacology Ayşe ÖZER, Professor of Medical Biology Ayşegül KARAHASAN, Professor of Microbiology Berrak YEĞEN, Professor of Physiology Betül ÇATALGÖL, Assistant Professor of Biochemistry Cevdet NACAR, Instructor in Biophysics Çiğdem Ataizi ÇELİKEL, Professor of Pathology Davut TÜNEY, Professor of Radiology Deniz GÜNEY DUMAN, Associate Professor of Internal Medicine - Gastroenterology Deniz ERTEM, Professor of Child Health and Diseases Feriha ERCAN, Professor of Histology and Embryology Funda EREN, Professor of Pathology Goncagül HAKLAR, Professor of Biochemistry Güner SÖYLETİR, Professor of Microbiology Gürsu KIYAN, Professor of Pediatric Surgery Hakan AKIN, Associate Professor of Internal Medicine Gastroenterology Halil TUĞTEPE, Associate Professor of Pediatric Surgery Handan KAYA, Professor of Pathology Hasan Raci YANANLI, Associate Professor of Pharmacology İnci ALİCAN, Professor of Physiology Melda KARAVUŞ, Professor of Public Health Neşe İMERYÜZ, Professor of Internal Medicine - Gastroenterology Nurver ÜLGER, Associate Professor of Microbiology Oya ORUN, Assistant Professor of Biophysics Osman ÖZDOĞAN, Professor of Internal Medicine - Gastroenterology Ömer ÖZDOĞMUŞ, Associate Professor of Anatomy Ömer Günal, Professor of General Medicine Önder ŞİRİKÇİ, Professor of Biochemistry Özgür KASIMAY, Instructor in Physiology Pemra C.ÜNALAN, Associate Professor of Family Medicine Pınar AY, Associate Professor of Public Health Rengin AHISKALI, Professor of Pathology Saime BATIREL, Assistant Professor of Biochemistry Serap ŞİRVANCI, Associate Professor of Histology and Embryology Sevcan AKESİ, Professor of Dentistry Şule ÇETİNEL, Professor of Histology and Embryology Ufuk HASDEMİR, Professor of Microbiology Ümit ŞEHİRLİ, Professor of Anatomy

5 Discipline SUMMARY OF THE COURSE Lecture& Group Discussion Basic Sciences Lab.& Clinical Skills Lab, Practice Medical Biology 1 Anatomy 18 8 Histology and Embryology 9 6 Physiology 15 Biochemistry 20 4 Biophysics 3 Microbiology 10 4 Pharmacology 5 Pathology 18 6 Internal Medicine 24 Pediatrics 1 General Surgery 1 Pediatric Surgery 1 Radiology 2 Nuclear Medicine 1 Family Medicine 2 Public Health 3 Dentistry 2 Subtotal PBL MODULE 9 Introduction to Clinical Practice Total TOTAL *Laboratory&practicals are shown as hours per student. Committee Exam Practical: Monday, 24 December 2012, 25 December 2012 Theoretical:, 28 December 2012

6 Course Faculty Member Week 1 30 October 2012 Introduction to the course and Opening Lecture Dr. Hakan AKIN Oral cavity, intraoral structures Dr. Ömer ÖZDOĞMUŞ Oral cavity, intraoral structures Dr. Ömer ÖZDOĞMUŞ Introduction to gastrointestinal system Dr. Berrak YEĞEN Histology of oral cavity, lip, tooth, tongue and esophagus Histology of oral cavity, lip, tooth, tongue and esophagus Dr. Şule ÇETİNEL Dr. Şule ÇETİNEL 31 October 2012 Salivary glands Dr. Ömer ÖZDOĞMUŞ Hygiene of oral cavity and dental health Sevcan AKESİ Hygiene of oral cavity and dental health Sevcan AKESİ LAB: Oral cavity, intraoral structures (group A) ANATOMY LAB: Oral cavity, intraoral structures (group B) ANATOMY 1 November 2012 Pathology of oral cavity and salivary glands Dr. Funda EREN Temporomandibular joint, muscles of mastication Dr. Ömer ÖZDOĞMUŞ Temporomandibular joint, muscles of mastication Dr. Ömer ÖZDOĞMUŞ LAB: Salivary glands, temporomandibular joint, muscles of mastication (A) ANATOMY LAB: Salivary glands, temporomandibular joint, muscles of mastication (B) ANATOMY 2 November 2012 Anterior abdominal wall Dr. Ömer ÖZDOĞMUŞ Anterior abdominal wall Dr. Ömer ÖZDOĞMUŞ Peritonum and Omenta Dr. Ümit ŞEHİRLİ Peritonum and Omenta Dr. Ümit ŞEHİRLİ

7 Week 2 5 November 2012 Monday Oral digestion and deglutition Dr. Hızır KURTEL Oral digestion and deglutition Dr. Hızır KURTEL Esophagus, stomach, duodenum and pancreas Dr. Ümit ŞEHİRLİ Esophagus, stomach, duodenum and pancreas Dr. Ümit ŞEHİRLİ Histology of stomach Dr. Feriha ERCAN Pathology of esophagus Dr. Funda EREN 6 November 2012 Tumors of the esophagus stomach and intestine Dr. Neşe İMERYÜZ Vessels of the abdomen Dr. Ümit ŞEHİRLİ Vessels of the abdomen Dr. Ümit ŞEHİRLİ Biochemical aspects of nutrition Dr. Nesrin Kartal ÖZER Biochemical aspects of nutrition Dr. Nesrin Kartal ÖZER 07 November 2012 LAB: Vessels of the abdomen (A) ANATOMY LAB: Vessels of the abdomen (B) ANATOMY LAB: Anterior abdominal wall, inguinal canal (A) ANATOMY LAB: Anterior abdominal wall, inguinal canal (B) ANATOMY Peritonum and Omenta (A) ANATOMY Peritonum and Omenta (B) ANATOMY 08 November 2012 Jejunum, ileum and colon Dr. Ümit ŞEHİRLİ Jejunum, ileum and colon Dr. Ümit ŞEHİRLİ Histology of small and large intestine Dr. Feriha ERCAN

8 HISTOLOGY LAB: Upper digestive tract (Group A) HISTOLOGY LAB: Upper digestive tract (Group A) HISTOLOGY LAB: Upper digestive tract (Group B) HISTOLOGY LAB: Upper digestive tract (Group B) 09 November 2012 Rectum and anal canal Dr. Ümit ŞEHİRLİ LAB: Esophagus, stomach, duodenum and pancreas (A) ANATOMY LAB: Esophagus, stomach, duodenum and pancreas (B) ANATOMY Exocrine functions of pancreas Dr. Hızır KURTEL Exocrine functions of pancreas Dr. Hızır KURTEL Week 3 12 November 2012 Monday Gastric digestion Dr. Berrak YEĞEN Gastric digestion Dr. Berrak YEĞEN HISTOLOGY LAB: Lower digestive tract (Group A) HISTOLOGY LAB: Lower digestive tract (Group A) HISTOLOGY LAB: Lower digestive tract (Group B) Multidisipli HISTOLOGY LAB: Lower digestive tract (Group B) 13 November 2012 Symptoms and signs of the gastrointestinal diseases Dr. Adnan GİRAL Symptoms and signs of the gastrointestinal diseases Dr. Adnan GİRAL 14 November 2012 LAB: Small and large intestine, rectum and anal canal (A) LAB: Small and large intestine, rectum and anal canal (B) ANATOMY ANATOMY

9 9:40-10:30 Pathology of gastritis and peptic ulcer disease Dr. Çiğdem ÇELİKEL Neoplastic diseases of stomach Dr. Çiğdem ÇELİKEL 11: Pharmacotherapy in peptic ulcer disease Dr. Atila KARAALP Dyspepsia in primary care Dyspepsia in primary care Dr. Pemra ÜNALAN& Dr. Arzu UZUNER Dr. Pemra ÜNALAN& Dr. Arzu UZUNER 15 November 2011 Histology of pancreas Dr. Serap ŞİRVANCI Liver, biliary and portal system Dr. Ümit ŞEHİRLİ Liver, biliary and portal system Dr. Ümit ŞEHİRLİ Peptic ulcus disease Dr. Adnan GİRAL Gastroesophageal reflux disease Dr. Adnan GİRAL 16 November 2012 Histology of the liver and portal system Dr. Serap ŞİRVANCI Histology of the liver and portal system Dr. Serap ŞİRVANCI LAB: Liver, biliary and portal system (Group A) ANATOMY LAB: Liver, biliary and portal system (Group B) ANATOMY Week 4 19 November 2012 Monday Detoxification mechanisms Dr. Betül ÇATALGÖL HISTOLOGY LAB: Liver, pancreas and salivary glands (Group A) HISTOLOGY LAB: Liver, pancreas and salivary glands (Group A) 20 November 2012 HISTOLOGY LAB: Liver, pancreas and salivary glands (Group B) HISTOLOGY LAB: Liver, pancreas and salivary glands (Group B) Development of digestive system Dr. Şule ÇETİNEL

10 Development of digestive system Dr. Şule ÇETİNEL The role of bile in the digestion Dr. Hızır KURTEL The role of bile in the digestion Dr. Hızır KURTEL Jaundice Dr. Hakan AKIN Gallstone disease, diseases of the biliary tract Dr. Osman ÖZDOĞAN 21 November 2012 Digestion of nitrogenous compounds, carbohydrates and fat Digestion of nitrogenous compounds, carbohydrates and fat Dr. Önder ŞİRİKÇİ Dr. Önder ŞİRİKÇİ Metabolism of carbohydrates Dr. Goncagül HAKLAR Metabolism of carbohydrates Dr. Goncagül HAKLAR Gastrointestinal absorption Dr. Özgür KASIMAY Gastrointestinal absorption Dr. Özgür KASIMAY 22 November 2012 Transport of digested compounds Dr. Önder ŞİRİKÇİ Transport of digested compounds Dr. Önder ŞİRİKÇİ Digestion in the small and large intestine Dr. Hızır KURTEL Functions of large intestine Dr. Hızır KURTEL Pathology of cholestatic disorders Dr. Çiğdem ÇELİKEL PBL MODULE-1 PBL MODULE 23 November 2012 Metabolism of carbohydrates Dr. Goncagül HAKLAR Metabolism of carbohydrates Dr. Goncagül HAKLAR Proteins in the diet and nitrogen metabolism Dr. Önder ŞİRİKÇİ Proteins in the diet and nitrogen metabolism Dr. Önder ŞİRİKÇİ Radiology of the gastrointestinal tract Dr. Davut TÜNEY Radiology of the gastrointestinal tract Dr. Davut TÜNEY Week 5 26 November 2012

11 Monday Regulation of temperature in the body, temperature transducers and thermography Dr. Cevdet NACAR Metabolism of aminoacids Dr. Önder ŞİRİKÇİ Diseases of the pancreas Dr. Deniz DUMAN PBL MODULE-2 PBL MODULE 27 November 2011 Porphyrins and bile pigments Dr. Önder ŞİRİKÇİ Porphyrins and bile pigments Dr. Önder ŞİRİKÇİ Pathology of exocrine pancreas, gall bladder and extrahepatic biliary tract Dr. Rengin AHISKALI Pathology of exocrine pancreas, gall bladder and extrahepatic biliary tract Dr. Rengin AHISKALI Metabolism of nucleotides Dr. Goncagül HAKLAR Application of heat and cold in medicine and human metabolism: energy work and power of body Dr. Cevdet NACAR Gastrointestinal system infections due to Escherichia coli Dr. Ayşegül KARAHASAN 28 November 2012 Heat and temperature, heat transfer in the body Dr. Oya ORUN Energy metabolism, energy turnover and balance Dr. İnci ALİCAN Physiological functions of vitamins Dr. Özgür KASIMAY Metabolism of inorganic compounds Dr. Betül ÇATALGÖL Acute abdominal pain Dr. Ömer GÜNAL Abdominal pain Dr. Hakan AKIN 29 November :00-17:30 ICP-3: Basic Medical Practices, Clinical Skills Lab., Student Research Activity-3 30 November 2012 Acute abdominal pain in children Dr. Halil TUĞTEPE Inborn errors of metabolism Dr. Çiğdem ÇELİKEL

12 Metabolic disorders of liver Dr. Çiğdem ÇELİKEL Gastric, intestinal and pancreatic function tests Dr. Saime BATIREL Gastric, intestinal and pancreatic function tests Dr. Saime BATIREL Week 6 3 December 2012 Monday Viral hepatitis Dr. Deniz DUMAN Viral hepatitis Dr. Deniz DUMAN Chronic hepatitis Dr. Deniz DUMAN Mushroom and insecticide poisoning Dr. Atila KARAALP PBL MODULE-3 PBL MODULE 04 December 2012 Drug and toxin induced liver disease Dr. Çiğdem ÇELİKEL Pathology of acute and chronic hepatitis Dr. Çiğdem ÇELİKEL Liver function tests Dr. Goncagül HAKLAR Liver function tests Dr. Goncagül HAKLAR BIOCHEMISTRY LAB: Transamination I A BIOCHEMISTRY LAB: Transamination II BIOCHEMISTRY LAB: Transamination III 05 December 2012 BIOCHEMISTRY LAB: Transamination IV Morphological patterns of hepatic injury and cirrhosis Dr. Çiğdem ÇELİKEL Pediatric liver disease Dr. Çiğdem ÇELİKEL Alcoholic and non-alcoholic liver disease Dr. Nurdan TÖZÜN Liver cirrhosis and complications Dr. Osman ÖZDOĞAN Liver cirrhosis and complications Dr. Osman ÖZDOĞAN Mass lesions of the liver Dr. Osman ÖZDOĞAN 06 December :40-9:30 9:40-10:30 Mass lesions of the liver Dr. Funda EREN Mass lesions of the liver Dr. Funda EREN Hepatobiliary scintigraphy Dr. Turgut TUROĞLU Epidemiology and laboratory diagnosis of viral hepatitis Dr. Güner SÖYLETİR Epidemiology and laboratory diagnosis of viral Dr. Güner SÖYLETİR

13 07 December 2012 hepatitis Pharmacotherapy in hepatic disorders and the influence of liver function on drug disposition Dr. Hasan Raci YANANLI 09:00-17:30 ICP-3: Basic Medical Practices, Clinical Skills Lab., Student Research Activity-3 Week 7 10 December 2011 Monday Infections due to vibrio cholerae and campylobacter species Dr. Ayşegül KARAHASAN Infections due to Salmonella, Shigella and Yersinia Dr. Nurver ÜLGER Viral gastroenteritis Dr. Ufuk HASDEMIR PBL MODULE-4 PBL MODULE PBL MODULE EXAMINATION 11 December 2012 Infections due to intestinal protozoa Dr. Nurver ÜLGER Infectious enterocolitis Dr. Handan KAYA Gastroenteritis/Dehydration and oral rehydration Dr. Deniz ERTEM Malabsorption, maldigestion Dr. Neşe İMERYÜZ Epidemiology of gastrointestinal diseases Dr. Neşe İMERYÜZ Food additives Dr. Emel LÜLECİ 12 December 2012 Epidemiology of food and waterborne disease Dr. Pınar AY Epidemiology of zoonotic disease Dr. Pınar AY Helminth infections and echinococcosis Dr. Ayşegül KARAHASAN Microbiological approach to the patient with diarrhea Dr. Ayşegül KARAHASAN BIOCHEMISTRY LAB: Transamination I B BIOCHEMISTRY LAB: Transamination II BIOCHEMISTRY LAB: Transamination III 13 December 2012

14 BIOCHEMISTRY LAB: Transamination IV Malabsorption syndromes, vascular disorders and diverticular disease Dr. Çiğdem ÇELİKEL Inflammatory bowel disease Dr. Çiğdem ÇELİKEL Malabsorption and maldigestion in children Dr. Deniz ERTEM Nutritional Assessment: Degree of malnutrition Dr. Deniz ERTEM Food poisoning Dr. Nurver ÜLGER 14 December 2012 Motility disorders of esophagus Dr. Adnan GİRAL Inflammatory bowel disease Dr. Hakan AKIN Inflammatory bowel disease Dr. Hakan AKIN Tumors of the small, large intestine and appendix Dr. Handan KAYA Colon tumors Dr. Neşe İMERYÜZ Molecular abnormalities in colon cancers Dr. Ayşe ÖZER Week 8 17 December 2012 Monday 18 December :40-10:3 Pharmacotherapy of gastrointestinal motility disorders Pharmacotherapy of gastrointestinal motility disorders MICROBIOLOGY LAB: Examination of stool samples (A) MICROBIOLOGY LAB: Examination of stool samples (A) MICROBIOLOGY LAB: Examination of stool samples (B) MICROBIOLOGY LAB: Examination of stool samples (B) MICROBIOLOGY LAB: Examination of stool samples (A) MICROBIOLOGY LAB: Examination of stool samples (A) MICROBIOLOGY LAB: Examination of stool samples (B) MICROBIOLOGY LAB: Examination of stool samples (B) Dr. Ahmet AKICI Dr. Ahmet AKICI

15 19 December 2012 PATHOLOGY LAB: Upper GI tract pathology (Group A) PATHOLOGY LAB: Upper GI tract pathology (Group A) PATHOLOGY LAB: Upper GI tract pathology (Group B) PATHOLOGY LAB: Upper GI tract pathology (Group B) PATHOLOGY LAB: Lower GI tract pathology (Group A) PATHOLOGY LAB: Lower GI tract pathology (Group A) PATHOLOGY LAB: Lower GI tract pathology (Group B) PATHOLOGY LAB: Lower GI tract pathology (Group B) Time for Lecture Compensation Time for Lecture Compensation Time for Lecture Compensation 20 December 2012 Time for Lecture Compensation Time for Lecture Compensation Time for Lecture Compensation Time for Lecture Compensation 21 December 2012 PATHOLOGY LAB: Pathology of liver and gallbladder (A) PATHOLOGY LAB: Pathology of liver and gallbladder (A) PATHOLOGY LAB: Pathology of liver and gallbladder (B) PATHOLOGY LAB: Pathology of liver and gallbladder (B)

16 Week 9 24 December 2012 Monday Practical exam Practical exam Practical exam Practical exam 25 December 2012 Practical exam Practical exam Practical exam Practical exam 26 December December December 2012

17 Theoretical exam Theoretical exam Theoretical exam Theoretical exam