Ταξινόμηση και συγκριτική μελέτη Ευρωπαϊκών τραπεζών βιολογικού υλικού

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1 Ταξινόμηση και συγκριτική μελέτη Ευρωπαϊκών τραπεζών βιολογικού υλικού Αραμπατζής Α., Παπαγιουβάννη Ι., Ανεστάκης Δ., Τσολάκη Μ. Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης

2 Εισαγωγή Βιοτράπεζες Λειτουργία & Ρύθμιση

3 Ερωτήματα Κύρια χαρακτηριστικά? Ταξινόμηση? Χρήση βιολογικών υλικών? Συμβολή στην επιστημονική πρόοδο?

4 Δείγμα 12 χώρες Επιστημονικό έργο 41 βιοτράπεζες Αριθμός πρόσφατων δημοσιεύσεων 15 βιοτράπεζες 56 βιοτράπεζες

5 ΤΑΞΙΝΟΜΗΣΗ

6 1. Τύποι βιοτραπεζών Population-based biobanks Disease-oriented biobanks 90% DNA banks Cell banks Tissue banks (e.g. brain banks) Group of participantsdonors Type of specimen collected Purpose/intended use of samples Supporting institution/ownership Research (e.g. clinical case-control studies) Source for therapeutics Transplantation processes Universities Hospitals Non-profit organizations

7 2. Τομέας ασθενειών Diseases of the nervous system Neoplasms Endocrine, nutritional and metabolic diseases Diseases of the circulatory system Diseases of the musculoskeletal system and connective tissue Diseases of the blood and blood-forming organs and certain General/Other Congenital malformations, deformations and chromosomal Mental and behavioural disorders Certain infectious and parasitic diseases Diseases of the respiratory system Diseases of the digestive system Diseases of the eye and adnexa Diseases of the skin and subcutaneous tissue Diseases of the genitourinary system Pregancy, childbirth and the puerperium Diseases of the ear and the mastoid process Certain conditions originating in the perinatal period

8 3. Τύπος συλλεγόμενου βιοϋλικού Type of collected biological Number of biobanks Number of biobanks (%) samples DNA 38 68% RNA 17 30% Blood 13 23% Serum 20 36% Plasma 21 38% Tissues 37 66% Cell lines 25 45%

9 4. Γεωγραφική εντόπιση 25 Number of biobanks Italy France Germany United Kingdom Spain Romania Netherlands Hungary Malta Slovenia Poland Estonia 0 Countries

10 ΣΤΑΤΙΣΤΙΚΗ ΣΥΣΧΕΤΙΣΗ

11 Μέθοδος: Αριθμός δημοσιεύσεων 100 Minimum coefficient (%) Number of disease groups 1 % Maximum coefficient Number of disease groups Minimum coefficient Minimum coefficient % Total number of publications Minimum number of publications in a disease group 100 Maximum coefficient % Total number of publications Maximum number of publications in a disease group 100 Number of disease groups Coefficient (Minimum-Maximum) 2 33,3-66, , , , , , ,7-15,3 13 7,1-14,8 14 6,7-12,9 15 6,3-11,8 16 5,9-11,5 17 5,6-10,4 18 5,3-9,9

12 Αριθμός δημοσιεύσεων- Κατηγορία ασθενειών Neoplasms Diseases of the nervous system Endocrine, nutritional and metabolic diseases Diseases of the musculoskeletal system and connective tissue Diseases of the circulatory system Diseases of the skin and subcutaneous tissue Mental and behavioural disorders Diseases of the respiratory system Diseases of the blood and the blood-forming organs and certain disorders General/Other Diseases of the digestive system Congenital malformations, deformations and chromosomal abnormalities Diseases of the genitourinary system Certain infectious and parasitic diseases Diseases of the eye and adnexa Pregnancy, childbirth and the puerperium Diseases of the ear and mastoid process Certain conditions originating in the perinatal period

13 Αριθμός δημοσιεύσεων σε ένα τομέα ασθενειών- Αριθμός βιοτραπεζών σε ένα τομέα ασθενειών t n P ( 18; 10 )

14 Αριθμός δημοσιεύσεων- Τύπος συλλεγόμενου βιολογικού υλικού Number of publications DNA Tissues Cells Serum Plasma Blood RNA Type of collected biological sample

15 Αριθμός δημοσιεύσεων- Αριθμός δειγμάτων DNA t 2.69( n 37; P 0.05)

16 Αριθμός δημοσιεύσεων- Αριθμός δειγμάτων RNA t 5.6( n 16; P 10) 4

17 Συμπεράσματα O ρόλος των βιοϋλικών στην έρευνα: DNA, RNA Ιστοί, Αίμα, ΕΝΥ κ.α.? Βιοτράπεζες Δικτύωση-Κατηγοριοποίηση Ηθικά ζητήματα

18 Πανελλήνια Βιοτράπεζα Νευρολογικών Νοσημάτων (ΠΑ.ΒΙ.Ν.Ν.)

19 Σας ευχαριστώ!

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