Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED # of 1! 35 Dr. Kenneth Bertram/MCMR-AC/(301)

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1 Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED # of 1! 35 Dr. Kenneth Bertram/MCMR-AC/(301) /kenneth.a.bertram.civ@mail.mil UNCLASSIFIED

2 Current and Future Challenges for Military Medical Technologies" Dr. Kenneth Bertram US Army Medical Research and Materiel Command Principal Assistant for Acquisition June 7, 2016

3 PURPOSE/OUTLINE"» Purpose to find better, available sooner, less costly solutions to Military medical gaps or opportunities» Outline» Infectious Diseases (ID)» Humanitarian Aid» Military Operational Medicine (MOM)» Combat Casualty Care (CCC)» Clinical Rehabilitative Medicine (CRM)» Presentation Strategy Audience participation» Threats/Gaps and Protection/Treatment/Recovery» How to work with us Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED Slide 3 of 35

4 COMBAT CASUALTY CARE" Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED Slide 4 of 35

5 SCENARIO #1 ON PATROL"» Troops in formation, helicopter, grass field» Threats/Gaps; Protection» Troops on patrol» Threats/Gaps; Protection» Soldier in Tactical Operations Center (TOC)» Threats/Gaps; Protection Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED Slide 5 of 35

6 ON PATROL THREATS/PROTECTION"» Troops in formation» Dust, noise, enemy fire, IEDs, flying debris» Protection: Uniforms, helmets» Troops on combat patrol» Enemy fire, IEDs => wounds, bleeding, TBI» Fatigue, lack of sleep, disorientation, lack of concentration => poor judgment» Protection: Gloves, IFAK, training, (knowledge, Soldier aids)» Soldier entering TOC» Protective eyewear Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED Slide 6 of 35

7 INFECTIOUS & ENDEMIC DISEASES" Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED Slide 7 of 35

8 SCENARIO #2 HUMANITARIAN AID"» Medic providing care to child (generalize to local population)» Soldier accompanied by children in a village Dr. Kenneth Bertram/MCMR-AC/(301) /kenneth.a.bertram.civ@mail.mil UNCLASSIFIED Slide 8 of 35

9 HUMANITARIAN AID THREATS"» Medic providing care to child (generalize to local population)» Combat threats» Endemic and emerging infectious diseases» Lack of Civilian medical care» Soldier accompanied by children in a village» Combat threats» Environmental exposures (heat, soil, air, water)» Venoms and toxins (Rabies, snakes, insects) Dr. Kenneth Bertram/MCMR-AC/(301) /kenneth.a.bertram.civ@mail.mil UNCLASSIFIED Slide 9 of 35

10 HUMANITARIAN AID PROTECTION"» Vaccines (yellow fever, Japanese encephalitis)» Vaccines in development (e.g., malaria, dengue)» Drugs (e.g., anti-malarials)» Humanitarian care sets» Testing for water and soil contaminants» Clean water; disposal of waste (burn pits?)» Rabies vaccine and IgG; anti-venoms» Anti-vector measures (uniform, tents, repellents) Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED Slide 10 of 35

11 MILITARY OPERATIONAL MEDICINE" Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED Slide 11 of 35

12 SCENARIO #3 PHYSICAL TRAINING"» Soldiers running, jumping, getting stronger Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED Slide 12 of 35

13 PHYSICAL TRAINING THREATS"» Musculoskeletal injuries» Backs» Knees» Ankles» Feet» Environmental conditions» Heat/Cold» Altitude» Wet Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED Slide 13 of 35

14 PHYSICAL TRAINING PROTECTION"» Evaluating supplements (e.g., to prevent shin splints Ca+2; Vitamin D)» Nutritional support» Soldier tools (risk management hydration, altitude, fatigue)» Cooling tank» Training (technical bulletins knowledge) Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED Slide 14 of 35

15 POST-DEPLOYMENT HEALTH" Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED Slide 15 of 35

16 SCENARIO #4 SOLDIER/FAMILY"» Soldier standing tall» Soldier with family» Soldier at home Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED Slide 16 of 35

17 SOLDIER/FAMILY THREATS"» TBI» PTSD» Suicide» Pain medication addiction» Substance abuse» Stress to family (deployments, injuries, financial)» Isolation (especially for Reserves/Guard) Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED Slide 17 of 35

18 SOLDIER/FAMILY PROTECTION"» TBI diagnostics and treatment» Resilience training» Suicide prevention» Less addicting drugs» Substance abuse treatment» Family studies» Tele-support Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED Slide 18 of 35

19 SENSORY HEALTH" Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED Slide 19 of 35

20 SCENARIO #5 VEHICLES"» Soldiers in/around helicopters» Soldiers in Humvees Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED Slide 20 of 35

21 VEHICLES THREATS"» Sensory deprivation (sight, sound)» Helicopter accidents» Ground vehicle accidents» Combat threats» IED injuries» Burns (skin and lungs)» Decision making/impairment Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED Slide 21 of 35

22 VEHICLES PROTECTION"» Sensory protection/augmentation» Accident evaluation includes Aeromedical Lab» Threat warnings for aircraft cognition» Accel/deceleration studies» Head carriage studies» Fatigue and sleep indicators» Vehicle modifications (undercarriage design)» Burn care skin replacement; lung?» Wound care/prosthetics/regenerative medicine Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED Slide 22 of 35

23 INJURY PREVENTION & REDUCTION" Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED Slide 23 of 35

24 SCENARIO #6 AIRBORNE"» Soldiers lifting» Soldiers parachuting» Soldiers raising tent Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED Slide 24 of 35

25 AIRBORNE THREATS/PROTECTION"» Musculoskeletal injuries» Activity related» Combat related» Regenerative repair of injured body parts» Nerves» Bone» Vascular» Muscle» Joint/tissue/organ Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED Slide 25 of 35

26 HEALTH IT" Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED Slide 26 of 35

27 SCENARIO #7 MEDICAL"» Pharmacy THREATS/PROTECTION"» Electronic medical records» Ready Soldiers Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED Slide 27 of 35

28 MEDICAL READY FORCE"» Chief of Staff of the Army Readiness is our number one priority» Medically Ready Force» Physically and mentally prepared and protected» Ready Medical Force» Resources (people, funding, infrastructure)» Medical supplies (clamps => CT scanners; combat hospital)» Training; clinical experience => learning organization» Research => medical solutions (material and knowledge)» Communications: care and records Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED Slide 28 of 35

29 WARFIGHTER THREATS" Endemic Disease Threats Parasitic Diseases Bacterial Diseases Viral Diseases Chemical/Biological Warfare Threats Bacterial Threats Viral Threats Toxin Threats Nerve Agents Vesicant Agents Blood Agents Environmental Hazards Heat and Cold Altitude Toxic Industrial Chemicals and Materials Combat Injuries Hemorrhage Head Trauma Blast Injury Operational Stressors Sleep Deprivation Traumatic Stress and Situational Stressors Physical Work Load Cognitive Burden and Operational Complexity Battle Sequelae Loss of limbs Loss of tissue Loss of vision Pain Dr. Kenneth Bertram/MCMR-AC/(301) Dr. Kenneth Bertram/MCMR-AC/(301) Systems Hazards Blast Noise UNCLASSIFIED UNCLASSIFIED # of Slide 2935 of 35

30 INFECTIOUS DISEASES"» Parasitic Diseases New drugs and vaccines to prevent and treat malaria; assessments of existing drugs for improved safety, and efficacy» Viral Diseases Flavivirus and acute respiratory disease; Hantaviruses, hemorrhagic fever viruses; HIV research» Bacterial Diseases Vaccines for bacterial diarrheal; Prevention and management of wound infections; Combatting antimicrobial resistance; Basic research in rickettsial diseases» Diagnostic Systems Diagnostic assays for naturally occurring infectious diseases for use in both field and fixed facility settings» Insect Vector Control Vector identification and threat assessment; Development of insecticides, repellents, and other control methods Dr. Kenneth Bertram/MCMR-AC/(301) Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED UNCLASSIFIED # of Slide 3035 of 35

31 MILITARY OPERATIONAL MEDICINE"» Return-to-duty standards and strategies after neurosensory and/or musculoskeletal injuries» Concussion dosimetry/mild traumatic brain injury assessment and neuroprotective strategies» Psychological health and suicide prevention» Sleep physiology and fatigue interventions» Nutritional strategies to promote injury recovery and healthy habits» Predictive models for heat and cold strain, hydration monitoring, and performance maintenance at altitude» Biomonitoring and other multidisplinary approaches to predict health effects from occupational stressors and environmental health hazards» Musculoskeletal and neurosensory injury prevention» Musculoskeletal physiology and injury recovery mechanisms to develop optimal physical training interventions Dr. Kenneth Bertram/MCMR-AC/(301) Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED UNCLASSIFIED # of Slide 3135 of 35

32 COMBAT CASUALTY CARE"»»»»»»»»» Blood products for resuscitation at or near the point of injury Advanced physiologic monitoring for triage and treatment support Interventions to control torso/non-compressible hemorrhage Damage control surgery techniques to provide life and limb saving surgery Organ support for combat casualty in prolonged field care Acute interventions for traumatic brain injury to improve outcomes Improvement of pre-hospital data collection and battlefield medical communication Response to tissue injury and improved healing after trauma Innovative treatments to speed full recovery after mtbi/concussion Dr. Kenneth Bertram/MCMR-AC/(301) Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED UNCLASSIFIED # of Slide 3235 of 35

33 CLINICAL AND REHABILITATIVE MEDICINE"» Rehabilitation of traumatic brain injury» Extremity trauma; advanced rehabilitation strategies, orthotics, and prosthetics; prevention and treatment of secondary health effects following injury» Management of acute and chronic pain» Regeneration of tissue components (skin, bone, muscle, nerve), craniofacial reconstructions, limb and digit regeneration, and genitourinary restoration» Repair of burn injury skin substitutes and burn injury inhibitors» Scarless wound healing and scar reduction» Vision restoration repair of ocular structures/function, retinal regeneration, and sensory substitution/augmentation devices» Repair to auditory and vestibular systems restoration of hearing and treatment of tinnitus and balance disorders Dr. Kenneth Bertram/MCMR-AC/(301) Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED UNCLASSIFIED # of Slide 3335 of 35

34 HOW TO WORK WITH US" For basic and applied research opportunities:» For advanced development opportunities:» Dr. Kenneth Bertram/MCMR-AC/(301) Dr. Kenneth Bertram/MCMR-AC/(301) UNCLASSIFIED UNCLASSIFIED # of Slide 3435 of 35

35 CONTACT US" Office of the Principal Assistant for Acquisition» Ms. Bonnie Adams ATTN: MCMR-AC 810 Schreider Street, Ft. Detrick, MD Office: Fax: » For more information about the USAMRMC:» To submit a product or idea:» Dr. Kenneth Bertram/MCMR-AC/(301) /kenneth.a.bertram.civ@mail.mil Dr. Kenneth Bertram/MCMR-AC/(301) /kenneth.a.bertram.civ@mail.mil UNCLASSIFIED UNCLASSIFIED # of Slide 3535 of 35

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