Appendix B Fiscal Years

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1 Appendix B s...shaping the future of health care to prevent, control, and cure diseases.

Appendix B Appendix B Appendi The Office of the ly Directed Medical s (CDMRP) was established with a congressional appropriation of $20 million (M) for peer reviewed

At this time, the CDMRP assumed responsibility for the science management of the FY92 Breast Cancer grants that had been executed by another Directorate within the U.

As a steward of these appropriated funds, the Department of Defense is responsible and accountable for the disbursement of each taxpayer dollar.

2 Appendix B Appendix B Appendi The Office of the ly Directed Medical s (CDMRP) was established with a congressional appropriation of $20 million (M) for peer reviewed breast cancer research to be administered by the U.S. Army in fiscal year 993 (FY93). At this time, the CDMRP assumed responsibility for the science management of the FY92 Breast Cancer grants that had been executed by another Directorate within the U.S. Army Medical and Materiel Command. As a steward of these appropriated funds, the Department of Defense is responsible and accountable for the disbursement of each taxpayer dollar. A detailed summary of all funds obligated for FY02 and FY03 programs can be found in this appendix. In some instances, proposals received in response to one FY solicitation are funded with dollars from another FY appropriation. Decisions to fund in this manner are made in the best interest of the scientific community and the government and/or upon recommendations of CDMRP Integration Panels. B-2

3 Appendix B Appendix B Appendix B Appendix B Append Table B-. FY02 03 Breast Cancer Language and,, and Execution of $ 50 M for Army peer reviewed Breast Cancer $,540,55 in proceeds from the Stamp Out Breast Cancer Act Withholds $3,750,000 U SAMRMC: $ 4,388,000 2 $2,854,643 (9.%) 3 Uncommitted $0 Biotechnology Clinical Partnership: $3,92,254 Clinical Translational (CTR): $ 8,965,448 Concept Awards: $ 7,598,248 Exploration Awards: $4,426,948 Idea Awards: $ 47,757,96 Innovator Awards: $ 2,973,424 Training/Recruitment Clinical Nurse: $,888,38 4 HBCU/MI Training: $,850,925 Physician Scientist $2,960,246 Postdoctoral Training: $ 0,28,45 Predoctoral Training: $ 7,55,522 Undergraduate Summer Training: $,03,428 Infrastructure Breast Cancer Center of Excellence: $9,637,953 Communication $26,79 $5,540,55 $20,992,643 $30,547,908 $ 50 M for Army peer reviewed Breast Cancer $ 2,28,259 in proceeds from the Stamp Out Breast Cancer Act Withholds Information Technology Development: $324,000 Business Process Reform: $2,000 $ 3,739,000 $ 5,04,000 Budgeted 2 $5,434,420 (3.8%) Budgeted Peer Reviewed $ 37,495,839 $52,28,259 $4,722,420 $37,495,839 The following abbreviations are used for withholds: SBIR, Small Business Innovation ; USAMRMC, United States Army Medical and Materiel Command. 4 Historically Black Colleges and Universities/Minority Institutions. B-3

4 Appendix B Appendix B Appendix B Appendix B Appendix Table B-2. FY02 03 Prostate Cancer Language and,, and Execution of $ 85 M for the Army peer reviewed Prostate Cancer $ 85 M for the Army peer reviewed Prostate Cancer Withholds $2,25,000 $2,486,000 2 $2,330,780 (2.9%) Health Disparity - Prostate Scholar: $2,223,543 Idea Development: $43,806,84 New Investigator Awards: $9,87,00 Prostate Cancer Clinical Trial: $23,866 Prostate Cancer Consortium: $9,93,56 Training/Recruitment Health Disparity Training- Prostate Scholar: Postdoctoral Training: $89,822 $2,624,639 $85M $6,94,780 $78,058,220 Withholds Information Technology Development: $84,000 Business Process Reform: $69,000 $2,9,000 $2,892,000 Budgeted 2 $5,503,880 (6.9%) Budgeted Peer Reviewed $74,232,20 $85M $0,767,880 $74,232,20 The following abbreviations are used for withholds: SBIR, Small Business Innovation ; USAMRMC, United States Army Medical and Materiel Command. B-4

5 Appendix B Appendix B Appendix B Appendix B Append Table B-3. FY02 03 Neurofibromatosis Language and,, and Execution of $ 2 M for Neurofibromatosis Withholds General Reduction: $5,000 $2,000 Business Process Reform: $47,000 $546,000 $33,000 Supplemental Rescissions: $44,000 OMB Mid- Inflation Reductions: $84,000 $607,000 2 $553,423 (2.8%) Idea Development: Investigator-Initiated Awards: New Investigator Awards: Therapeutic Development Awards: Training/Recruitment Career Development: $2,404,339 $2,967,627 $2,755,87 $64,740 $26,000 $ 20 M for Neurofibromatosis $2M $2,04,423 $8,958,577 Withholds Rescissions: DA Withhold: $279,000 $58,000 $3,000 $29,000 $656,000 Budgeted 2 $,470,000 (8.0%) Budgeted Peer Reviewed $6,97,000 $20M $3,083,000 $6,97,000 The following abbreviations are used for withholds: FFRDC, Federally Funded and Development Center; SBIR, Small Business Innovation ; STTR, Small Business Technology Transfer; OMB, Office of and Budget; USAMRMC, United States Army Medical and Materiel Command; DA, Department of the Army. B-5

6 Appendix B Appendix B Appendix B Appendix B Appendix Table B-4. FY02 03 Ovarian Cancer Language and,, and Execution of $ 0.2 M for the Ovarian Cancer Withholds $255,000 $298,000 Idea Development: $8,288,898 Projects: $227,507 2 $530,595 (5.5%) Training/Recruitment Institutional Training Grant: $600,000 $ 0 M for the Ovarian Cancer $0.2M $,083,595 $9,6,405 Withholds Information Technology Development: $22,000 Business Process Reform: $8,000 $249,000 $340,000 Budgeted 2 $938,000 (0.0%) Budgeted Peer Reviewed $8,443,000 $0M $,557,000 $8,443,000 The following abbreviations are used for withholds: SBIR, Small Business Innovation ; USAMRMC, United States Army Medical and Materiel Command. B-6

7 Appendix B Appendix B Appendix B Appendix B Append Table B-5. FY02 03 Peer Reviewed Medical Language and,, and Execution of $ 50 M for the Peer Reviewed Medical $ 50 M for the Peer Reviewed Medical 5 Withholds 2 $,250,000 $,463,000 3 $,642,89 (3.5%) 4 Uncommitted $ 0 Acute Lung Injury: $3,347,775 Chemo-Preventative Approaches to Smoking-Related Illness: $,26,963 Childhood Asthma: $920,999 Closed-Loop Frozen Blood Processing Systems: $,499,96 Dengue Fever Vaccine: $,079,876 High-Risk Infectious Disease: $3,68,903 Laser Eye Injury: $,599,027 Metabolically Engineered Tissue for Trauma Care: $340,355 Military Nutrition : $2,80,303 Military Relevant Disease : $4,60,969 Paget's Disease: $834,27 Preclinical and Clinical Activities of the Novonex/Ex-Rad Drugs: $,584,656 Radiation Protection: $88,09 Real-Time Heart-Rate Variability: $89,4 Sleep : $796,468 Smoking Cessation: $2,92,298 Social Work : $,553,78 Traumatic Brain Injury: $6,387,992 $50M $4,355,89 $45,644,8 2 Withholds Information Technology Development: $08,000 Business Process Reform: $40,000 $,246,000 $,70,000 Budgeted 3 $4,065,000 (8.7%) Budgeted Peer Reviewed $42,840,000 $50M $7,60,000 $42,840,000 FY02 Conference Committee Report No , p. 394 PEER REVIEWED MEDICAL RESEARCH PROGRAM The Senate recommended $50,000,000 for a Peer Reviewed Medical program.the conferees agree to provide $50,000,000 for this program, and recommend that the Department of Defense consider the following projects as candidates for study: Complex rad-vector vaccine for MGBV; chemo-preventative approaches to smoking related illness; childhood asthma; chiropractic care; closed loop frozen blood processing systems; Counter Narcotics Tactical Operations Medical Support ; Dengue Fever vaccine; high risk infectious disease; medications for fungal and bacterial infections such as Fungi Free; metabolically engineered tissue for trauma care; military nutrition research; Padget s disease; pre-clinical and clinical activities of the Novonex/Ex-Rad drugs; radiation protection; real-time heart rate variability; self test methods of screening for cervical cancer; smoking cessation; social work research;traumatic Brain injury; Volume Angio Cat research and VRE research. 2 The following abbreviations are used for withholds: SBIR, Small Business Innovation ; USAMRMC, United States Army Medical and Materiel Command. 3 Percent of management costs = management costs/(appropriation withholds). 4 Uncommitted is money returned to the Treasury. 5 FY03 Conference Committee Report No , p PEER REVIEWED MEDICAL RESEARCH PROGRAM The conferees agree to provide $50,000,000 for this program, and recommend the following projects as candidates for study: acellular matrix research for military orthopedic trauma; alcoholism research; amyotrophic lateral sclerosis; anti-diarrhea supplement; Army nutrition research; augmented care in the chain of stroke survival (ACCESS); blood-related cancer research; bone-related disease research; cell response to anti-cancer agents; Mt. Sinai cancer research program; casualty care research center; chiropractic care; epilepsy; infectious disease tracking system; interstitial cystitis research; low vision research; medical digital assistance; miniature renal assist devices; natural toxin detection technology; neuroscience research; Paget's disease; personal intelligent medical assistant; Providence cancer center; respiratory research; smoking cessation; social work research; and Volume Angio CAT (VAC) research. B-7

8 Appendix B Appendix B Appendix B Appendix B Appendix Table B-6. FY02 03 Chronic Myelogenous Leukemia Language and,, and Execution of $ 5M for the Chronic Myelogenous Leukemia $ 4.25M for the Chronic Myelogenous Leukemia Withholds $23,000 $29,000 Information Technology Development: $9,000 Business Process Reform: $3,000 2 FY02: $397,489 (8.4%) Budgeted FY03: $7,35 (5.5%) Investigator-Initiated Awards: $7,459,602 Balance Available for FY03 : $64,594 $9.25M $,48,804 $8,0,96 The following abbreviations are used for withholds: SBIR, Small Business Innovation ; USAMRMC, United States Army Medical and Materiel Command. B-8

9 Appendix B Appendix B Appendix B Appendix B Append Table B-7. FY02 03 Tuberous Sclerosis Language and,, and Execution of $ M fortuberous Sclerosis Complex (TSC) Withholds 2 $25,000 $29,000 3 $76,000 (8.0%) Idea Awards: $870,000 $ 2 M fortsc Uncommitted 4 $ 0 $M $30,000 $870,000 Withholds 2 Information Technology Development: $4,000 Business Process Reform: $2,000 $50,000 $68,000 Budgeted 3 $50,000 (8.0%) Budgeted Peer Reviewed $,35,998 Idea Awards (FY02): $374,002 $2M $274,000 $,726,000 Only for TSC research to better understand the role and function of proteins produced by the TSC and TSC2 tumor suppressor genes. 2 The following abbreviations are used for withholds: SBIR, Small Business Innovation ; USAMRMC, United States Army Medical and Materiel Command. 3 Percent of management costs = management costs/(appropriation withholds). 4 Uncommitted is money returned to the Treasury. B-9

10 Appendix B Appendix B Appendix B Appendix B Appendix Table B-8. FY02 03 National Prion Language and Appropriation,, and Execution of Appropriation $ 42.5 M for the National Prion Project Withholds $,063,000 $,243,000 2 $2,79,740 (6.9%) Idea Awards: $7,789,37 Investigator-Initiated Awards: $27,77,604 Training/Recruitment Career Transition Awards: $,565,776 Prion Techniques Fellowship: $35,743 Communication $240,000 $42.5M $5,097,740 $37,402,260 The following abbreviations are used for withholds: SBIR, Small Business Innovation ; USAMRMC, United States Army Medical and Materiel Command. B-0

11 Appendix B Appendix B Appendix B Appendix B Append Table B-9. FY02 03 Institutionally Based Language and,, and Execution of Alcoholism $ 5.6 M for Neurology Gallo Center-Alcoholism 2 ithholds W General Reduction: $4,000 $3, Rescission: 39,000 $46,000 $9, Rescission: $2,000 OMB Inflation: $22,000 $62,000 anagement Cost M s $208,000 (4%) Gallo Center for Alcoholism $4,995,000 $ 3.5 M for Neurology Gallo Center-Alcoholism $5.6M $605,000 $4,995,000 Withholds Rescissions: DA Withhold: $49,000 $9,000 $5,000 $23,000 $5,000 Budgeted 2 $22,000 (4.0%) Gallo Center for Alcoholism $3,095,000 $3.5M $405,000 $3,095,000 Arthropod-Borne Infectious Disease Control $ 2.5 M for Arthropod-Borne Infectious Disease Control ithhold W s General Reduction: $2,000 $, Rescission: $8,000 $65,000 $4, Rescission: $5,000 OMB Inflation: $0,000 $72,000 Budgeted 2 $7,000 (5.0%) Arthropod-Borne Infectious Disease Control $2,206,000 $2.5M $294,000 $2,206,000 The following abbreviations are used for withholds: FFRDC, Federally Funded and Development Center; SBIR, Small Business Innovation ; STTR, Small Business Technology Transfer; OMB, Office of and Budget; USAMRMC, United States Army Medical and Materiel Command; DA, Department of the Army. B-

12 Appendix B Appendix B Appendix B Appendix B Appendix Table B-9. FY02 03 Institutionally Based Language and,, and Execution of (cont.) Breast Cancer Imaging $ 6 M for peer reviewed Breast Cancer Imaging Withholds Information Technology Development: $3,000 Business Process Reform: $5,000 $50,000 $204,000 Peer Reviewed Breast Cancer Imaging : $5,346,600 Cancer Center of Excellence $ 2. M for Cancer Center of Excellence 2 $28,400 (5.0%) $6M $653,400 $5,346,600 ithhold W s General Reduction: $,000 $, Rescission: $5,000 $55,000 $3, Rescission: $4,000 OMB Inflation: $9,000 $6,000 2 $77,000 (4.0%) Cancer Center of Excellence $,874,000 $2.M $226,000 $,874,000 The following abbreviations are used for withholds: FFRDC, Federally Funded and Development Center; SBIR, Small Business Innovation ; STTR, Small Business Technology Transfer; OMB, Office of and Budget; USAMRMC, United States Army Medical and Materiel Command; DA, Department of the Army. B-2

13 Appendix B Appendix B Appendix B Appendix B Append Table B-9. FY02 03 Institutionally Based Language and,, and Execution of (cont.) Center for Prostate Disease $ 6.4 M for Center for Prostate Disease at Walter Reed Army Medical Center ithhold W s General Reduction: $5,000 $4, Rescission: $45,000 $66,000 $0, Rescission: $3,000 OMB Inflation: $26,000 $85,000 Center for Prostate Disease $ 5,866,000 $ 5.7 M for Center for Prostate Disease at Walter Reed Army Medical Center Children's Hospice $.5 M for Children' s Hospice (Note: only for a demonstration project at Walter Reed Army Medical Center to structure, implement, and provide oversight of a program serving children with life-threatening illnesses, diseases, or conditions who have parents or custodial care givers serving in the U.S. Military [including the Reserve components] or retired from the U.S. military.) 2 $80,000 (.0%) $6.4M $534,000 $5,866,000 Withholds Rescissions: DA Withhold: $79,000 $48,000 $9,000 $37,000 $87,000 Budgeted 2 $5,000 (.0%) Center for Prostate Disease $5,89,000 $5.7M $5,000 $5,89,000 Withholds Rescission:s DA Withhold: $20,000 $39,000 $2,000 $0,000 $49,000 Budgeted 2 $70,000 (5.0%) Children's Hospice $,30,000 $.5M $90,000 $,30,000 The following abbreviations are used for withholds: FFRDC, Federally Funded and Development Center; SBIR, Small Business Innovation ; STTR, Small Business Technology Transfer; OMB, Office of and Budget; USAMRMC, United States Army Medical and Materiel Command; DA, Department of the Army. B-3

14 Appendix B Appendix B Appendix B Appendix B Appendix Table B-9. FY02 03 Institutionally Based Language and,, and Execution of (cont.) Fragile X $ M for Fragile X (Note: only to support an intervention study aimed at finding effective methods of treatment - both pharmacological and non- pharmacological - for the symptoms and behavioral problems associated with Fragile X Syndrome.) 2 ithholds W General Reduction: $,000 $, Rescission: $7,000 $26,000 $2, Rescission: $2,000 OMB Inflation: $4,000 $29,000 $47,000 (5%) Fragile X Syndrome $88,000 Gallo Cancer Center $.05 M for Prostate Cancer - Gallo Cancer Center Hepatitis C $ 3.4 M for Hepatitis C $M $9,000 $88,000 Withholds Rescissions: DA Withhold: $4,000 $27,000 $2,000 $7,000 $34,000 Budgeted 2 $48,000 (5.0%) Gallo Cancer Center $98,000 $.05M $32,000 $98,000 ithhold W s General Reduction: $2,000 $2, Rescission: $24,000 $88,000 $5, Rescission: $7,000 OMB Inflation: $4,000 $98,000 2 $74,76 (5.5%) Hepatitis C $2,985,284 $3.4M $44,76 $2,985,284 The following abbreviations are used for withholds: FFRDC, Federally Funded and Development Center; SBIR, Small Business Innovation ; STTR, Small Business Technology Transfer; OMB, Office of and Budget; USAMRMC, United States Army Medical and Materiel Command; DA, Department of the Army. B-4

15 Appendix B Appendix B Appendix B Appendix B Append Table B-9. FY02 03 Institutionally Based Language and,, and Execution of (cont.) Lung Cancer $ 3.5 M for Biology, Education, Screening, Chemoprevention, and Treatment (BESCT) Lung Cancer ( MDACC) 2 Withholds General Reduction: $2,000 $2, Rescission: $25,000 $9,000 $5, Rescission: $7,000 OMB Inflation: $4,000 $0,000 3 $30,000 (4.0%) Lung Cancer $3,23,000 $ 9 M for BESCT Lung Cancer ( MDACC) Monoclonal Antibodies $ M for Monoclonal Antibodies - Massachusetts Biological Lab Uncommitted 4 $ 0 $3.5M $377,000 $3,23,000 2 Withholds Rescissions: DA Withhold: Budgeted 3 $26,000 $233,000 $4,000 $58,000 $295,000 $44,000 (5.0%) Lung Cancer $7,860,000 $9M $,40,000 $7,860,000 2 Withholds General Reduction: $,000 $, Rescission: $7,000 $26,000 $2, Rescission: $2,000 OMB Inflation: $4,000 $29,000 Budgeted 3 $47,000 (5%) Monoclonal Antibodies $88,000 $M $9,000 $88,000 MDACC stands for M.D. Anderson Cancer Center. 2 The following abbreviations are used for withholds: FFRDC, Federally Funded and Development Center; SBIR, Small Business Innovation ; STTR, Small Business Technology Transfer; OMB, Office of and Budget; USAMRMC, United States Army Medical and Materiel Command; DA, Department of the Army. 3 Percent of management costs = management costs/(appropriation withholds). 4 Uncommitted is money returned to the Treasury. B-5

16 Appendix B Appendix B Appendix B Appendix B Appendix Table B-9. FY02 03 Institutionally Based Language and,, and Execution of (cont.) Muscular Dystrophy $ 3.4 M for Muscular Dystrophy Withholds Information Technology Development: $7,000 Business Process Reform: $3,000 $85,000 $6,000 Muscular Dystrophy $3,024,000 Budgeted 2 $65,000 (5%) $3.4M $376,000 $3,024,000 The following abbreviations are used for withholds: SBIR, Small Business Innovation ; USAMRMC, United States Army Medical and Materiel Command. B-6

Defense Health Program Fiscal Year (FY) 2013 Budget Estimates Exhibit R-2, DHP RDT&E Budget Item Justification

Defense Health Program Fiscal Year (FY) 2013 Budget Estimates Exhibit R-2, DHP RDT&E Budget Item Justification COST: (Dollars in Millions) 2011 Actual 2012 Estimate 2013 Estimate 2014 Estimate 2015 Estimate 2016 Estimate 2017 Estimate Total PE 0603115 723.324 703.313 239.110 282.441 290.422 289.094 290.613 CoE-Breast