The new standard in hemorrhage control
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1 The new standard in hemorrhage control
2 Contents The need for hemostats What is Celox Rapid? Benefits How it works Performance Independent trials of Celox Gauze
3 The need for hemostats in trauma
4 Combat lives can be saved Preventable Combat Death Extremity Hemorrhage Tension pneumothorax Airway obstruction 60 % of preventable battlefield deaths are from extremity hemorrhage. Ref WDMET study
5 Civilians bleeding to death Trauma: leading cause of death for persons under Hemorrhage is the cause of death in around 40 % of civilian trauma. Rapid action saves lives
6 What is Celox Rapid?
7 The fastest acting battlefield hemostat
8 The Rapid Treatment The fastest hemostatic agent. Works with just 60 second compression. Controls the most severe bleeding. Saves blood saves lives.
9 Description Haemostatic agent for moderate to severe bleeding. FDA cleared. Not a drug Z-folded high density gauze. 5 ft x 3. Compact, rugged foil pouch with 4 quick-tear notches.
10 Activated chitosan Proprietary chitosan (Chito-R TM ). Bonded to gauze. Contains 9 g of Chito-R.
11 Celox Rapid is the ONLY pre-hospital hemostatic dressing that meets each of the ideal criteria of the US Army Acquisition Support Center. Able to stop actively bleeding arteries from hemorrhaging within 2 minutes Source: USAASC
12 Cut treatment time in half Faster packing & 60 second compression Combat Gauze* Celox Rapid
13 Rapid Packing Celox Rapid gauze is thicker than typical gauze. Five foot of Celox Rapid fills the same wound volume as 12 foot of Combat Gauze or Chitogauze. The time taken to pack in five foot of gauze is significantly less than that taken to pack 12 foot.
14 Works on the most severe injuries 100.0% 80.0% 60.0% 40.0% 20.0% 0.0% Celox Rapid Gauze Combat Gauze Study presented at ATACC Haemostasis with 60 second compression.
15 Independent testing at OHSU 60 % reduction in blood loss compared to Combat Gauze. Post-treatment blood loss (ml) Gauze Combat Gauze Celox Rapid Schreiber M, at Combat Trauma Innovation, January Published in American Journal of Surgery 2013.
16 No re-bleed during simulated evacuation test Field evacuation model Casualty driven over rough terrain course in vehicle. No re-bleed: Hoggarth et al. poster at ATACCC 2011.
17 Works on traumatic bleeding. In severe blood loss, blood becomes coagulopathic does not clot normally, as shock and hypothermia set in. Celox Rapid is effective on cooled, hypothermic blood. Celox Rapid is also effective on blood containing blood thinners.
18 Celox Rapid is safe No heat produced. Chitosan : made up of sugars the body uses (glucosamine, N-acetyl glucosamine). Chitosan from Shellfish: tested on patients with known shellfish sensitivity. No allergies. Does not activate clotting away from direct contact.
19 Celox Rapid is the only choice for fast, effective treatment of lifethreatening bleeding. Rapid action saves lives.
20 How it works
21 Simple mechanism 1. Chito-R absorbs fluid and forms an adhesive gel. 2. Adhesive gel plug seals the wound, stops blood flow. Adhesion is unique. Does not rely on the body s intrinsic clotting capability.
22 How to use 1. Identify bleeding site. 2. Pack high density gauze direct to source of bleeding, maintain pressure on bleed point. 3. Apply firm pressure for one minute or until bleeding stops. 4. Wrap and tie with a bandage to maintain pressure. Direct contact + pressure = success!
23 Removal 1. Pull out the gauze. Tip: the strong gauze comes out intact. Irrigate if needed if tightly adhered. 2. Remove any loose surface granules. 3. Irrigate liberally with saline.
24 Performance
25 Office of Naval Research Test Report
26 The key study for the CoTCCC Landmark study to change with support of CoTCCCC ONR did not have Celox Rapid at the time, so it was not in the test. Test included Celox Gauze. Celox Rapid is FDA approved and available. The test was done so that the CoTCCC could review the recommendation to use Combat Gauze
27 The products Celox Gauze 10 ft x 3 in Roll. Combat Gauze 12 ft x 3 in Z-fold. Combat Gauze XL 12 ft x 4in Double ply, Z fold. Celox Trauma Gauze 6 ft x 3 in roll. Chitogauze 12 ft x 3 in Z-fold.
28 Results: Haemostasis Celox Gauze 90 % hemostasis at end of study compared to Combat Gauze 60 %.
29 Survival CELOX Everyone else 90 % survival - matching the 90 % haemostasis.
30 Studies and references Reduced blood loss independent study from Oregon Health Science University - Kunio et al. poster at ATACCC % hemostasis after one minute compression compared to 50 % for Combat Gauze. Packs in half the time of other hemostats. No re-bleeds in trial of casualty evacuation. All: Hoggarth et al. poster at ATACCC % hemostasis compared to 83 % for Combat Gauze Schreiber M, presented at Combat Trauma Innovation, January Published military and civilian use of Celox Gauze Tan, Bleeker, Field experience with a chitosan-based haemostatic dressing. MCI Forum, 3/ Pdf copies available
31 Thank you
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