Educational Workshop. Budapest, November 30 - December 1, Advances in Predictive, Preventive and Personalised Medicine (PPPM) Organised by:

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1 Educational Workshop Advances in Predictive, Preventive and Personalised Medicine (PPPM) Budapest, November 30 - December 1, 2012 Organised by: European Association for Predictive, Preventive and Personalised Medicine, EPMA in Brussels and QUINTESS Knowledge Center in Budapest Organising Committee: Vincenzo Costigliola, President of EPMA Olga Golubnitschaja, Secretary-General of EPMA Filippo Ongaro, International Medical Director of Quintess Knowledge Center, Budapest György Fekete, Director of Quintess Knowledge Center, Budapest

2 Dear Colleagues, It is our great pleasure and honour to invite and welcome you to the Educational Workshop Advances in Predictive, Preventive and Personalised Medicine (PPPM), to be held in Budapest, Hungary. On behalf of the Organizing Committee, the European Association for Predictive, Preventive and Personalised Medicine (EPMA) and Quintess Knowledge Center, Budapest, we are pleased to announce that the venue of the first joint Workshop will be in one of the beautiful conference centers of the Hungarian capital, the Hotel Ramada Plaza Budapest, on November 30 - December 1, The hotel is located on the Buda side of the Danube bank, opposite to the picturesque Margaret Island. Why integrative medical approach by PPPM as the medicine of the future? PPPM is the new integrative concept in healthcare sector that enables to predict individual predisposition before onset of the disease, to provide targeted preventive measures and create personalised treatment algorithms tailored to the person. The expected outcomes are conducive to more effective population screening, prevention early in childhood, identification of persons at-risk, stratification of patients for the optimal therapy planning, prediction and reduction of adverse drug-drug or drug-disease interactions relying on emerging technologies, such as pharmacogenetics, pathology-specific molecular patters, sub/cellular imaging, disease modelling, individual patient profiles, etc. Education in integrative medicine People from various walks of life and socio-economic status are increasingly demanding to be better informed of anticipated changes in their health status as they progress through life. Although not simple, it is now feasible to predict and prevent tissue/organ deregulation associated with predisposition to particular pathologies such as premature aging, diabetes mellitus, neurodegenerative processes, cardiovascular disorders and cancer. Essential components of this approach is the professional education including innovative diagnostic technologies, targeted prevention of common human pathologies, optimal treatment strategies thereby resulting in substantial improvement of the quality of life. The examples provided at our Workshop are based on well-recognized expertise, scientific publications and international patents. A panel of leading world experts and authorities of the international issue-related associations contribute to the Workshop by addressing relevant issues such as patient profiling, individualized therapy planning and advanced healthcare. One of the central issues treated by the Workshop is the screening for predisposition of healthy individuals to potential pathologies later in life. 2

3 Book Series Advances in Predictive, Preventive and Personalised Medicine, EPMA / Springer This book series ( creates the robust scientific platform for our Educational Workshop, which overviews multidisciplinary aspects of advanced bio/medical approaches and innovative technologies. Integration of individual professional groups into the overall concept of PPPM is a particular advantage of this book series. Expert recommendations focus on the cost-effective management tailored to the person in health and disease. Principal audiences This Educational Workshop is for everyone! Here you can learn a new philosophy in medicine, novel trends in healthcare and bio/medical education. These may help you and your family to define your own way of creating a well chosen life-style. Our Workshop provides important information for individuals of various professional and scientific backgrounds. Professionals can consider the general concept of multidisciplinary approaches and learn the mindset of border areas and other scientific branches. The Host of the Workshop QUINTESS Knowledge Center as a non-profit organization has the mission to introduce newest, evidence-based methods of health care and prevention of diseases in Hungary and on international level. It promotes prevention-focused lifestyle, diagnostic and therapeutic methods in medicine. The Knowledge Center organizes informative programs, with accredited and credit-based college trainings, and scientific conferences. The spreading of knowledge creating a basis for raising the general awareness and the integration of preventive medicine into the health care system is one of the main goals of Quintess Knowledge Center. In addition to the high quality scientific program of the Educational Workshop, we hope to provide a friendly atmosphere to find new cooperations and personal contacts. We hope that the information provided at our Workshop will stimulate further discussions to address many issues in relation to the future practice of integrative medicine. We wish you a pleasant meeting! The Organizing Committee Dr. Vincenzo Costigliola Prof. Dr. Olga Golubnitschaja Dr. Filippo Ongaro Prof. Dr. György Fekete 3

4 Program Friday, November 30th Arrival of guests, registration Opening Ceremony and Introductory Lectures Opening Ceremony György Fekete, Filippo Ongaro, Vincenzo Costigliola, Olga Golubnitschaja, and Local Authorities Coffee Break Ceremony of Francis Crick Award Istvan Karádi, Dean of the Medical Faculty, Semmelweis University, Budapest Chair: Mária Judit Molnár, Olga Golubnitschaja Paradigm change from delayed interventional to predictive, preventive and personalised medicine - New trends in Europe Introductory Lecture by EPMA (Vincenzo Costigliola) Moving from top-science in innovative medicine to daily clinical practice - Patient in the focus Introductory Lecture by Quintess Knowledge Center (Filippo Ongaro, International Medical Director) Clinical aspects of DNA based personalised prediction Introductory Lecture by Semmelweis University (Mária Judit Molnár, Director of Institute of Genomic Medicine and Rare Disorders, Vice-Rector of Semmelweis University, Budapest) Quintess programmes in education, practical training, and health management of PPP medicine Introductory Lecture by Quintess Knowledge Center (György Fekete) New perspectives in predictive diagnostics and treatments tailored to the patient Introductory Lecture by Industry (Giorgio Vittadini, Bracco Imaging, Milan, Italy) Publishing in predictive, preventive and personalised medicine Introduction of the Book-Series Advances in Predictive, Preventive and Personalised Medicine, EPMA / Springer Introductory Lecture by Springer / BMC (Martijn Roelandse, The Netherlands) 4

5 Questions, discussion Welcome Party Saturday, December 1st Chair: Vincenzo Costigliola, Silvia Mandel Three Levels of Predictive, Preventive and Personalised Medicine in Advanced Pre / Diabetes Care Olga Golubnitschaja, Dept. Of Radiology, University of Bonn, Germany, Editor of the Book-Series Advances in Predictive, Preventive and Personalised Medicine, EPMA / Springer Economy of personalised medicine Kurt Krapfenbauer, Boehringer / University of Vienna, Austria Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future Silvia Mandel, Technion, Haifa, Israel Coffee Break Chair: Niva Shapira, György Németh Personalised medicine as the challenge to traditional therapeutics György Németh, Chief Medical Officer, Richter Gedeon PIc, President of Hungarian Society of Personalised Medicine, Budapest Drug delivery systems: advanced technologies potentially applicable in personalised treatment Jorge Coelho, University of Coimbra, Portugal Targeted therapy in breast cancer Magdolna Dank, Associate Professor, Dept. of Radiology and Oncology, Semmelweis University, Budapest Preventissiomo: e-health assessment and counselling Eva Palik, Zoltan Nacsa, Bernadett Toth, Judit Schmidt, Quintess Knowledge Center, Budapest Predictive, Preventive and Personalised Medicine in Dentistry Carlo Cafiero, University of Naples, Italy Targeted prevention of age-related chronic conditions Istvan Marton, Advisor, Quintess Knowledge Center, Budapest 5

6 Women s Health Risks in the Obesogenic Environment: The Integrative Approach for Gender Related Nutrition by Predictive, Preventive and Personalised Medicine Niva Shapira, Rabin Center, Tel Aviv, Israel Lunch Chair: Filippo Ongaro Practical PPPM Workshop Case studies I - Filippo Ongaro, International Medical Director, Quintess Knowledge Center, Budapest Case studies II - Tamas Gulyás, Quintess Knowledge Center, Budapest The hidden P s in PPPM: integrated patient participative and psychosomatic approach in systems medicine Monika Horváth, Quintess Knowledge Center, Budapest Coffee Break Chair: Sergej Suchkov, Olga Golubnitschaja Education for young professionals in predictive, preventive and personalised medicine Presentation by the EPMA-YPS, specialised section of young professionals Working group: Jiri Polivka Junior, Charles University, Medical Faculty in Pilzen, Czech Republic, Maria Bocharova, Medical University of Moscow, Russia Mentors: Sergej Suchkov, Medical University of Moscow, Russia, Jiri Polivka, Charles University, Medical Faculty in Pilzen, Czech Republic, Ondrej Topolcan, Charles University, Medical Faculty in Pilzen, Czech Republic Chair: István Marton, Judita Kinkorova Round-Table Discussion: Set-up of the European projects dedicated to the integrative medicine ( Horizon 2020 and others) Sunday, December 2nd Specialised programmes run by the EU-Commission: Judita Kinkorova, Consultant, Charles University, Prague, Czech Republic Social Programme (optional) - City Tour in Budapest 6

7 Dr. Vincenzo Costigliola graduated in Medicine at the Naples University in Italy Since Family Practice Chief of Medical service in Italian Navy. (Outpatients clinic, legal, occupational and preventive medicine); Chief of the Internal Medicine Service; Chief of Medical Staff on Military ships; Medical advisor: NATO; WEU (Western European Union) in Brussels, attached to the SHAPE (Supreme Headquarters Allied Powers Europe) President of EMA (European Medical Association), President of IRMA (International Rescue Medicine Association), President of EDA (European Depression Association), President of EPMA (The European Association for Predictive, Preventive and Personalised Medicine), Prof. Dr. Olga Golubnitschaja Book Series Editor Dr. Golubnitschaja, Department of Radiology, Medical Faculty of the University in Bonn, Germany, has studied journalism, biotechnology and medicine and has been awarded fellowships for biomedical research in Paediatrics and Neurosciences (Medical Centres in Austria, Russia, UK, Germany, the Netherlands, and Switzerland). She is well-cited in the research fields of gene hunting and subtractive hybridisation applied to predictive prenatal & postnatal diagnostics published as O.Labudova in years Dr. Golubnitschaja is an expert in molecular diagnostics actively publishing in the fields of perinatal diagnostics, Down syndrome, Diabetes mellitus, hyperhomocysteinemia, cardiovascular disease, neurodegenerative pathologies, cancer. She is the co-founder of the theory of multi-pathway organ-related blood fingerprinting with specific molecular patterns at epi/genomic, transcriptional and post/translational levels, author of fundamental works in integrative medicine. Dr. Golubnitschaja hold appointments, at the rank of Professor, at several European Universities and in International Programmes for Personalised Medicine and author of more than 300 international publications in the field. Awards: National & International Fellowship of the Alexander von Humboldt-Foundation; Highest Prize in Medicine and Eiselsberg-Prize in 7

8 Austria. She is Secretary-General of the European Association for Predictive, Preventive & Personalised Medicine (EPMA in Brussels, eu), Editor-in-Chief of The EPMA-Journal (BioMed Central, London); Book Editor of Predictive Diagnostics & Personalised Treatment: Dream or Reality, Nova Science Publishers, New York 2009; Book Co-editor Personalisierte Medizin, Health Academy, Dresden 2010; Book Series Editor Advances in Predictive, Preventive & Personalised Medicine, Springer 2012; European Representative in the EDR-Network at the NIH / NCI, gov/; Advisor and Evaluator of projects dedicated to personalised medicine at the EU-Commission in Brussels, NIH/NCI, Washington D.C., USA, Foundations and National Ministries of Health in several countries worldwide. Dr. Filippo Ongaro International Medical Director of Quintess Knowledge Center Dr.Filippo Ongaro graduated from the Faculty of Medicine at the University of Ferrara, Italy. He worked as a visiting lecturer at the German Sports University in Cologne, and then joined the European Space Agency (ESA). During his years at ESA, he was frequently invited to NASA s Johnson Space Center in Houston and to Russia s Gagarin Cosmonaut Training Center (the famous Star City ) where he worked together with a number of leading European and International scientists. He continues as a consultant of the ESA. He has been an invited speaker at many conferences, with topics ranging from space medicine and anti-aging to nutrigenomics (nutritional science based on genetics) and endocrinology. Dr. Ongaro is a leader and member of several prestigious organizations including the Institute for Regenerative and Anti-Aging Medicine (ISMERIAN) as Medical Director based in Treviso, Italy; and is a member the American Association of Clinical Endocrinologists (AACE), the International Society of Gynecological Endocrinology (ISGE) and the Quintess Health Center s Science Committee. He is also the author of two books published in Italy, and is a popular guest on Italian television and radio programs. 8

9 Prof. Dr. György Fekete, Ph.D., D.Sc. Director of Quintess Knowledge Center, specialist in Paediatrics, Clinical Genetics, and Clinical Pharmacology. He was appointed as the Chairman of the II. Department of Paediatrics, Semmelweis University, Budapest for 15 years, till July He is serving the Department of Paediatrics as an active Professor at the present, as well. His main scientific research interests are genetic diagnosis, early detection, prevention and treatment of inborn errors of metabolism. He is the Chief of the Cytogenetic and Molecular Genetic Laboratories and Genetic Counselling Service of the Department. He was invited as research fellow and visiting professor to the Universities of Marburg and Munich, Germany, and to the Institute of Medical and Molecular Genetics of Indiana University, Indianapolis, USA. He has been the author and editor of several paediatric and genetic textbooks and scientific publications. As the former President of the Hungarian Society of Paediatrics and General Secretary of the Hungarian Society of Human Genetics he contributed to the development of these disciplines in Hungary. The Royal College of Physicians, London, and the European Society of Paediatric Research elected him to be one of their members. His medical, research and teaching activities were honoured by several awards. 9