STUDY PROGRAMME 2009/2010. Elective Courses GENERAL MEDICINE & DENTISTRY. University of Pécs Medical School

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1 University of Pécs Medical School GENERAL MEDICINE & DENTISTRY STUDY PROGRAMME 2009/2010 Elective Courses 1

2 Course Code Guide 4 Applied Medical Psychology 10 Basic Principles of Electron Microscopy in Clinical Practice and Biological Research _ 12 Basics of Gerontology 14 Basic Surgical Techniques 16 Behavioral Medicine 18 Behavioral Science 1 (Medical Anthropology) 20 Behavioral Science 2 (Medical Ethics) 22 Behavioral Science 3 (Medical Sociology) 24 Bioinorganic Chemistry 26 Biometrics and Computing 28 Biophysical Basis of Diagnostic and Therapeutic Methods 35 Cardiac Surgery 37 Cases in Clinical Radiology 39 Chemistry of Bioactive Organic Compounds 41 Clinical Pathophysiology 1 43 Clinical Pathophysiology 2 45 Clinical Pharmacology 47 Clinicopathological Cases in Nephrology and Hypertension 49 Clinicopathology 51 Complex Pathophysiological Mechanisms 52 Current Issues and New Surgical Techniques 54 Dental Clinical Informatics 2 55 Dissection Practices in Regional Anatomy 57 Emergency Psychiatry 59 Experiments in Molecular Cell Biology 1 61 Experiments in Molecular Cell Biology 2 63 Health Psychology 65 High-Risk Pregnancy 67 History of Medicine 69 Hormonal Regulatory Mechanisms in Health and Disease 71 Hunger, Satiety And Disturbances of Body Weight Regulation 73 Immunpathology 1 75 Kinesiology 77 Medical English 2/a - Presentation Techniques 79 Medical English 2/b - Taking Medical Case Histories in English 81 Medical English 2/b - Taking Pharmaceutical Case Histories in English 83 Medical Hungarian 1A - Communication Skills 3 2

3 Medical Hungarian 1B - Language Points 5 Medical Hungarian 2A - Communication Skills 7 Medical Hungarian 2B - Language Points 9 Medical Hungarian 3A - Basics of Medical Communication 11 Medical Hungarian 3B - Medical Communication in Practice 13 Medical Hungarian 4A - Basics of Medical Communication 15 Medical Hungarian 4B - Medical Communication in Practice 17 Medical Informatics 19 Neurosurgery 21 Neurotraumatology 23 Non-invasive Cardiological Diagnostics and Therapy 25 Nursing Skills Theory - Hospital Care 27 Operative Dentistry Propedeutics - Practice A" 29 Operative Dentistry Propedeutics - Practice B 31 Operative Surgical Techniques 33 Paediatric Surgery 35 Palliative Care, Hospice 37 Pharmaceutical English 2/a - Presentation Techniques 39 Pharmaceutical Hungarian 1A - Communication Skills 41 Pharmaceutical Hungarian 1B - Language Points 43 Pharmaceutical Hungarian 2A - Communication Skills 45 Pharmaceutical Hungarian 2B - Language Points 47 Physical Basis of Biophysics 49 Prevention of Infectious Diseases: Challenges and Solutions for Practicing Doctors 51 Prosthodontics Basics Practice A 54 Prosthodontics Basics Practice B 55 Psychosomatic Approach in Medicine 56 Sexology 58 Specialities in Orthopaedics 60 Two-Dimensional Anatomy - Modern Medical Imaging Techniques 62 3

4 COURSE CODE GUIDE General Medicine code title rec. sem. spring/fall credit OAEMS1 Experiments in Molecular Cell Biology 1 1 fall 2 OAEOTT History of Medicine 1 both 2 OAEH1A Medical Hungarian 1A - Communication Skills 1 fall 2 OAEH1B Medical Hungarian 1B - Language Points 1 fall 2 OAEBFA Physical Basis of Biophysics 1 both 2 OAEEMA Basic Principles of Electron Microscopy in Clinical Practice and Biological Research 2 spring 2 OAEBSK Bioinorganic Chemistry 2 spring 2 OAEBVK Chemistry of Bioactive Organic Compounds 2 spring 2 OAETAJ Dissection Practices in Regional Anatomy 2 spring 2 OAEMS2 Experiments in Molecular Cell Biology 2 2 spring 2 OAEANA Medical English 2/a - Presentation Techniques 2 both 2 OAEANB Medical English 2/b - Taking Medical Case Histories in English 2 both 2 OAEH2A Medical Hungarian 2A - Communication Skills 2 spring 2 OAEH2B Medical Hungarian 2B - Language Points 2 spring 2 OAEEPS Health Psychology 3 both 2 OAEHOS OAEEHS Hormonal Regulatory Mechanisms in Health and Disease Hunger, Satiety And Disturbances of Body Weight Regulation 3 fall 2 3 fall 1 OAEMOZ Kinesiology 3 fall 2 4

5 code title rec. sem. spring/fall credit OAEH3A OAEH3B OAEH4A OAEH4B Medical Hungarian 3A - Basics of Medical Communication Medical Hungarian 3B - Medical Communication in Practice Medical Hungarian 4A - Basics of Medical Communication Medical Hungarian 4B - Medical Communication in Practice 3 fall 2 3 fall 2 4 spring 2 4 spring 2 OAESEX Sexology 4 both 2 OAE2DA Two-Dimensional Anatomy - Modern Medical Imaging Techniques 4 spring 1 OAEIM1 Immunpathology 1 5 fall 2 OAEOLA Applied Medical Psychology 6 spring 1 OAEGER Basics of Gerontology 6 spring 2 OAEMAO Behavioral Medicine 6 spring 2 OAEDMB Biophysical Basis of Diagnostic and Therapeutic Methods 6 spring 2 OAEKLP Clinicopathology 6 spring 1 OAESMT Operative Surgical Techniques 6 spring 1 OAEFBE Prevention of Infectious Diseases: Challenges and Solutions for Practicing Doctors 6 spring 2 OAEKK1 Clinical Pathophysiology 1 7 fall 1 OAEKKM Complex Pathophysiological Mechanisms 7 fall 1 OAEAKM Current Issues and New Surgical Techniques 7 fall 1 OAEPSO Psychosomatic Approach in Medicine 7 fall 1 OAERAM Cases in Clinical Radiology 8 spring 1 5

6 code title rec. sem. spring/fall credit OAEKK2 Clinical Pathophysiology 2 8 spring 1 OAEKFA Clinical Pharmacology 8 spring 2 OAEOIN Medical Informatics 8 spring 1 OAENKD Non-invasive Cardiological Diagnostics and Therapy 8 spring 2 OAESSE Cardiac Surgery 9 both 1 OAESUP Emergency Psychiatry 9 fall 1 OAEPAH Palliative Care, Hospice 9 fall 1 OAEORS Specialities in Orthopaedics 9 fall 2 OAENKE Clinicopathological Cases in Nephrology and Hypertension 10 spring 1 OAENKT High-Risk Pregnancy 10 spring 1 OAEIDS Neurosurgery 10 spring 1 OAENTR Neurotraumatology 10 spring 1 OAEGYS Paediatric Surgery 10 spring 2 6

7 Dentistry code title rec. sem. fall/spring credit OSEANT Behavioral Science 1 (Medical Anthropology) 1 fall 1 OSEOET Behavioral Science 2 (Medical Ethics) 1 fall 1 OSEMET Biometrics and Computing 1 fall 2 OSEMS1 Experiments in Molecular Cell Biology 1 1 fall 2 OSEOTT History of Medicine 1 both 2 OSEH1A Medical Hungarian 1A - Communication Skills 1 fall 2 OSEH1B Medical Hungarian 1B - Language Points 1 fall 2 OSEBFA Physical Basis of Biophysics 1 both 2 OSEANA Medical English 2/a - Presentation Techniques 2 both 2 OSEANB Medical English 2/b - Taking Medical Case Histories in English 2 both 2 OSEBSK Bioinorganic Chemistry 2 spring 2 OSEBVK Chemistry of Bioactive Organic Compounds 2 spring 2 OSEMS2 Experiments in Molecular Cell Biology 2 2 spring 2 OSEH2A Medical Hungarian 2A - Communication Skills 2 spring 2 OSEH2B Medical Hungarian 2B - Language Points 2 spring 2 OSEAPI Nursing Skills Theory - Hospital Care 2 spring 1 OSEH3A OSEH3B OSEHOS Medical Hungarian 3A - Basics of Medical Communication Medical Hungarian 3B - Medical Communication in Practice Hormonal Regulatory Mechanisms in Health and Disease 7 3 fall 2 3 fall 2 3 fall 2

8 code title rec. sem. fall/spring credit OSEEHS Hunger, Satiety and Disturbances of Body Weight Regulation 3 fall 1 OSESZO Behavioral Science 3 (Medical Sociology) 4 spring 2 OSEH4A OSEH4B Medical Hungarian 4A - Basics of Communication for Students of Dentistry Medical Hungarian 4B - Language Points and Skills Development for Students of Dentistry 4 spring 2 4 spring 2 OSESEX Sexology 4 both 2 OSEMUA Basic Surgical Techniques 5 fall 2 OSEFPP-A Prosthodontics: Basics - PRACTICE A 5 fall 2 OSEFPP-B Prosthodontics: Basics - PRACTICE B 5 fall 2 OSEDMB Biophysical Basis of Diagnostic and Therapeutic Methods 6 spring 2 OSEKLP Clinicopathology 6 spring 1 OSEFK2 Dental Clinical Informatics 2 6 spring 2 8

9 Pharmacy code title rec. sem. spring/fall credit OPEMS1 Experiments in Molecular Cell Biology 1 1 fall 2 OPEANB OPEH1A Medical English 2/b - Taking Pharmaceutical Case Histories in English Pharmaceutical Hungarian 1A - Communication Skills 1 fall 2 1 fall 2 OPEH1B Pharmaceutical Hungarian 1B - Language Points 1 fall 2 OPEANA Pharmaceutical English 2/a - Presentation Techniques 1 fall 2 OPEBFA Physical Basis of Biophysics 1 both 2 OPEMS2 Experiments in Molecular Cell Biology 2 2 spring 2 OPEH2A Pharmaceutical Hungarian 2A - Communication Skills 2 spring 2 OPEH2B Pharmaceutical Hungarian 2B - Language Points 2 spring 2 9

10 APPLIED MEDICAL PSYCHOLOGY Course director: 1 credit Elective spring semester midsemester grade Number of hours/semester (lect. + pract. + semin): = 14 Headcount limitations: DR. JÓZSEF VARGA, research fellow Department of Behavioural Sciences course code prerequisite 1 prerequisite 2 prerequisite 3 rec. semester GENMED OAEOLA OAPMT DENT PHARM Topic This course deals with psychological aspects of medical practice, focusing on common issues, like: development of physician s identity; risk factors of medical profession; becoming ill and recovering; practice of empathy; effective communication and interviewing and sources of errors; basics of psychoterapeutic approach in general practice. Conditions for acceptance of the semester According to the Code of Studies and Examinations. Making up for missed classes Additional homework. Reading material Csabai, M., Molnár, P.: Health, Illness and Care. A Textbook of Medical Psychology. Springer Orvosi Kiadó, Budapest, Kaptein, A., Weinman, J. (eds). Health Psychology. BPS Blackwell Publishing, Feldman, M. D., Chiistensen, J.F. (eds): Behavioral Medicine in Primary Care. A Practical Guide. Appleton and Lange, Stamford, Connecticut, Lectures Practices 1. Becoming a physician, mental health and medical profession. 2. Becoming a physician, mental health and medical profession. 3. Becoming ill, meaning of illness, coping with illness. 4. Becoming ill, meaning of illness, coping with illness. 5. Effective doctor-patient relationship, empathy. 6. Effective doctor-patient relationship, empathy. 7. Effective communication in the doctor-patient relationship. 8. Effective communication in the doctor-patient relationship. 9. Interview and history taking, biases in communication.

11 10. Interview and history taking, biases in communication. 11. Psychodynamic approach in doctor-patient relationship. 12. Psychodynamic approach in doctor-patient relationship. 13. Cognitive and behavioral techniques in general practice. 14. Cognitive and behavioral techniques in general practice. Seminars Exam topics/questions -- 11

12 BASIC PRINCIPLES OF ELECTRON MICROSCOPY IN CLINICAL PRACTICE AND BIOLOGICAL RESEARCH Course director: DR. LÁSZLÓ SERESS, professor Central Electron Microscope Laboratory 2 credit Elective spring semester midsemester grade Number of hours/semester (lect. + pract. + semin): = 28 Headcount limitations: 5 20 course code prerequisite 1 prerequisite 2 prerequisite 3 rec. semester GENMED OAEEMA OAAMB DENT PHARM Topic Methods of electron microscopic fixation, embedding and sectioning and the use of the electron microscope. Demonstration of the subcellular elements in details and of a few tissues and organs. Demonstration of the electron microscopic methods used in the biological research. The use of electron microscopic methods in the clinical practice. The basic principles of electron microscopy will be discussed and we provide information about the mode and the use of electron microscopy in the basic research and in the clinical practice. Conditions for acceptance of the semester Participation on 80% of the seminars. Oral examination with analysis of electron microscopic photographs Making up for missed classes No Reading material Suggested only: Dr Szabolcs Virágh: Ultrastructural Pathology and Diagnostic Electron Microscopy Leon Weiss: Histology. Cell and Tissue Biology Lectures 1. Purpose and indication of the electron microscopic examination. The role of fixation in tissue preservation, the recognition of cells, cellular organelles etc. 2. Most frequent failures in the electronmicroscopic practice 3. Optimal fixation for electron microscopy. Composition of fixatives for different tissue samples. Electron microscopy of formaldehyde fixed and paraffin embedded materials. 4. Samples taken by autopsy or biopsy. Perfusion of experimental animals for electron microscopy. 5. The ultrastructure of the cell I. 12

13 6. The ultrastructure of the cell II. 7. The ultrastructure of the cell III. 8. The ultrastructure of the cell IV. 9. The ultrastructure of viruses and bacteria 10. Virus replication 11. Ultrastructures of neurons (axon, dendrite, synapses) 12. Ultrastructure of glial cells 13. The ultrastructure of kidney 14. The ultrastructure of the liver 15. Ultrastructure of cell multiplication and cell death. 16. Necrotic and apoptotic changes in the dying cells. Dark cells. 17. Combined light and electron microscopic methods, such as Golgi/EM, Timm/EM, immunocytochemistry/em. 18. Combination of degeneration and axon transport methods with electron microscopy. 19. Ultrastructure of the muscle 20. Cytosceleton 21. Intercellular connections 22. The use of EM in the biological research 23. Summary 24. Examination Practices 15. Electron microscopic grids and coating membranes. The use of transmission electron microscope (light, focus, contrast, photo). 16. Analysis of tissue in the electron microscope 17. Analysis of tissue in the electron microscope II. 18. Analysis of tissue in the electron microscope III. Seminars Exam topics/questions None 13

14 BASICS OF GERONTOLOGY Course director: 2 credit Elective spring semester midsemester grade Number of hours/semester (lect. + pract. + semin): = 28 Headcount limitations: 5 30 DR. MIKLÓS SZÉKELY, professor Department of Pathophysiology and Gerontology course code prerequisite 1 prerequisite 2 prerequisite 3 rec. semester GENMED OAEGER OAPKO1 OAPBPR - 6 DENT PHARM Topic The population is aging. Knowledge of special physiological, psychosocial aspects, agerelated problems and methods of care may help adequate health provision for the elderly patients. Conditions for acceptance of the semester Absence from less than 15% (max. 3) of lectures. Answering the questions of a written account. Making up for missed classes Writing an essay from the topic of the omitted lecture. Reading material The Merck Manual of Geriatrics (MSD, Rathway, 1990) Lectures 1. Concepts of gerontology. Demography 2. Biological/chronological age. Physiological aging 3. Biological theories of aging I 4. Biological theories of aging II 5. Acute/chronic diseases, polimorbidity in the elderly 6. Problems of diagnosis and therapy 7. Homeostatic functions and aging 8. Adaptability, vulnerability 9. Cardiorespiratory disorders in the elderly I 10. Cardiorespiratory disorders in the elderly II 11. Changes of energy balance 12. Gastrointestinal changes in the elderly 13. Endocrine changes with age 14. Diabetes mellitus in the elderly 15. Renal functions: changes with age 14

15 16. Salt/water balance changes with age 17. Dietetics in the gerontological practice I 18. Dietetics in the gerontological practice II 19. Gait disorders, motor system in the elderly 20. Aging and immune processes 21. Psychosocial factors in gerontology I 22. Psychosocial factors in gerontology II 23. Geriatric syndromes I 24. Geriatric syndromes II 25. Rehabilitation 26. Chronic care, nursing 27. Problems of the caretaking team 28. Test-exam Practices Seminars Exam topics/questions Written account (test) from the topics of the course. 15

16 BASIC SURGICAL TECHNIQUES Course director: 2 credit Elective fall semester midsemester grade Number of hours/semester (lect. + pract. + semin): = 28 Headcount limitations: 3 50 DR. GYÖRGY WÉBER, professor Department of Surgical Research and Techniques course code prerequisite 1 prerequisite 2 prerequisite 3 rec. semester GENMED DENT OSEMUA OSAEN2 OSAAA2-5 PHARM Topic The aim of the subject is to practice the elemental surgical techniques, to present hygienic approach, which attainments are indispensable for clinical doctors working in manual field of medicine. This subject give basics about special behavior in the operating theatre, preparation of the patent and surgical team before operation, surgical tools and instruments, wound management, microsurgical instruments and techniques. Conditions for acceptance of the semester According to the Code of Studies. Making up for missed classes Attendance is obligatory on every practice. Because of limited capacity of operating theatre, absence cannot be repeated by joining another group. One missed practice can be repeated on 11 th week of the semester. The exact time will be on the website of the institute ( Reading material Lectures 1. Presentation of the Department and the curriculum. The history of surgery. 2. The operation (acute, elective, patient preoperative management, surgical explorations). 3. Classification and managements of wounds, principle of wound-healing, haemorrhage and bleeding control. 4. Basic surgical tools and surgical materials, wound closure techniques. 5. Demonstration of the operating room and technical background, sterilisation, desinfection. 6. Basics of microsurgery. 16

17 Practices 1. The basic rules of the behavior in the operating theatre; scrubbing-gowninggloving, preparation of the operation area (desinfection, isolation). 2. The basic rules of the behavior in the operating theatre; scrubbing-gowninggloving, preparation of the operation area (desinfection, isolation). 3. Demonstration of the basic surgical tools, practicing their use. 4. Demonstration of the basic surgical tools, practicing their use. 5. Knot tying. 6. Knot tying. 7. Sutures and suture materials, suture removal. 8. Sutures and suture materials, suture removal. 9. Practicing of basic sutures on pig tissue. 10. Practicing of basic sutures on pig tissue. 11. Practicing of basic sutures on pig tissue. 12. Practicing of basic sutures on pig tissue. 13. Tissue preparation, bleeding control and wound closure on anaesthetized animals. 14. Tissue preparation, bleeding control and wound closure on anaesthetized animals. 15. Abdominal wall closure techniques on anesthetized animals. 16. Abdominal wall closure techniques on anesthetized animals. 17. Basics of microsurgery: demonstration of microsurgical tools, using of operation microscope. 18. Basics of microsurgery: demonstration of microsurgical tools, using of operation microscope. 19. Training of microsurgical suturing techniques. 20. Training of microsurgical suturing techniques. 21. Practical exam, skill assessment. 22. Practical exam, skill assessment. Seminars Exam topics/questions 17

18 BEHAVIORAL MEDICINE Course director: 2 credit Elective spring semester midsemester grade Number of hours/semester (lect. + pract. + semin): = 28 Headcount limitations: 5 20 DR. JÓZSEF VARGA, research fellow Department of Behavioural Sciences course code prerequisite 1 prerequisite 2 prerequisite 3 rec. semester GENMED OAEMAO OAPMT DENT PHARM Topic Strong evidences support that health condition, illness and life expectancies are determined by the individual s life style and behavior. Patients illness behavior and coping abilities have an impact on the outcome of illness and rehabilitation. This course introduces into the processes of health behavior and behavior changing focusing on the therapeutic aspects of chronic diseases and specific clinical fields. Conditions for acceptance of the semester According to the Code of Studies and Examinations. Making up for missed classes Additional homework. Reading material Feldman, M. D., Christensen, J.F. (eds): Behavioral Medicine in Primary Care. A Practical Guide. Appleton and Lange, Stamford, Connecticut, C Csabai, M., Molnar, P.: Health, Illness and Care. A Textbook of Medical Psychology. Springer Orvosi Kiadó, Budapest, Kaptein, A., Weinman, J. (eds): Health Psychology. BPS Blackwell Publishing, Lectures Practices 1. Models of health and illness. Influence of behavior on health and illness. 2. Models of health and illness. Influence of behavior on health and illness. 3. Psychovegetative correlates of behavior and emotions. 4. Psychovegetative correlates of behavior and emotions. 5. Relationship, understanding, compliance, adherence in the practice of behavioral medicine. 6. Relationship, understanding, compliance, adherence in the practice of behavioral medicine. 7. Behavioral and psychological aspects of chronic illness. 8. Behavioral and psychological aspects of chronic illness. 18

19 9. Psychosocial risk factors and psychological rehabilitation of cardiovascular diseases. 10. Psychosocial risk factors and psychological rehabilitation of cardiovascular diseases. 11. Psychosomatics of gastrointestinal diseases and eating disorders. 12. Psychosomatics of gastrointestinal diseases and eating disorders. 13. Psychological reactions, risk factors and coping in oncological diseases. Psychoimmunology. 14. Psychological reactions, risk factors and coping in oncological diseases. Psychoimmunology. 15. Psychological issues in gynecology and pulmonology. 16. Psychological issues in gynecology and pulmonology. 17. Pain syndrome, psychological methods of pain management. 18. Pain syndrome, psychological methods of pain management. 19. Behavioral medicine in treatment of dependencies. 20. Behavioral medicine in treatment of dependencies. 21. Cognitive approaches in behavioral medicine. 22. Cognitive approaches in behavioral medicine. 23. Behavioral methods in general practice. 24. Behavioral methods in general practice. 25. Behavior, culture and illness. 26. Behavior, culture and illness. 27. Summary, discussion, exam. 28. Summary, discussion, exam. Seminars Exam topics/questions -- 19

20 BEHAVIORAL SCIENCE 1 (MEDICAL ANTHROPOLOGY) Course director: DR. ZSUZSANNA FÜZESI, associate professor Department of Behavioural Sciences 1 credit Elective fall semester midsemester grade Number of hours/semester (lect. + pract. + semin): = 14 Headcount limitations: 1 50 course code prerequisite 1 prerequisite 2 prerequisite 3 rec. semester GENMED DENT OSEANT none PHARM Topic Medical Anthropology can shortly be described as a subfield of anthropology that draws upon philosophical, cultural, and biological anthropology to better understand those factors which influence human health and well-being. Within this scope, there are many different theoretical approaches which have contributed to the development of medical anthropology. At least three of these have to receive special mention. First, the ecological approach underlying the interaction between individuals and the biological/cultural environments forms an immediately useful conceptual framework. Second, theory of evolution and adaptation biology, basis of all biological sciences, provides the necessary temporal landscape. Finally, links with the cognitive sciences gives a better insight into the cognitive parameters of illness. With a special focus on the first, the course of medical anthropology covers all relevant approaches of the modern medical anthropology. Conditions for acceptance of the semester Attending the lectures. Making up for missed classes -- Reading material Lecture notes Peter J. Brown: Understanding and Applying Medical Anthropology, 1998, Mayfield Publishing C. London. Donald Joralemon: Exploring Medical Anthropology, 1999, Allyn and Bacon (recommended) Tony McMichael: Human Frontiers, Environments and Disease, 2001, Cambridge, Univ. Press, (recommended). Lectures 1. The subfields of Anthropology. The discipline of medical anthropology 2. The levels of human thinking, the essence of human 3. The role of human culture, coping with the environment 4. The complexity of human behaviour 20

21 5. Rationality 6. The evolution of human intelligence. 7. Interaction between the environment and the human response-systems 8. Main adaptation agents I.: Human biocultural adaptation to infectious disease 9. Main adaptation agents II.: Human nutritional evolution 10. Main adaptation agents III.: Human adaptation to climate. 11. Human aging, cross-cultural comparisons 12. Pain perception and its biocultural variability 13. Placebo-Nocebo effect. 14. The basis of human aggression and its variability Practices Seminars 21

22 BEHAVIORAL SCIENCE 2 (MEDICAL ETHICS) Course director: DR. ZSUZSANNA FÜZESI, associate professor Department of Behavioural Sciences 1 credit Elective fall semester midsemester grade Number of hours/semester (lect. + pract. + semin): = 14 Headcount limitations: course code prerequisite 1 prerequisite 2 prerequisite 3 rec. semester GENMED DENT OSEOET PHARM Topic The course helps the students gain sensitivity regarding the ethical aspects of medical practice, and to become aware of the different ethical approaches. The main aim of the course is to assist the students in developing their own ethical attitudes. Conditions for acceptance of the semester Attendance, written test Making up for missed classes -- Reading material Dr. Erich H. Loewy and Dr. Roberta Springer Loewy, Textbook of Healthcare Ethics, Kluwer Academic Publishers, Dordrecht, Biomedical Ethics, edited by Thomas A. Mappes et al, McGraw-Hill Higher Education, 4th edition, Lectures Practices Seminars 1. The differences between traditional medical ethics and modern bioethics 2. Rationality and ethics 3. The main moral theories 4. The principle of informed consent 5. The moral status of abortion 6. Ethical issues concerning transplantation 7. Problems in the care of the terminally ill 8. The ethical concerns of human experimentation 9. The ethical concerns of animal experimentation 10. Genethics 11. Neuroethics 22

23 12. Techniques of case analysis 13. Summarizing discussion 14. Written test Exam topics/questions -- 23

24 BEHAVIORAL SCIENCE 3 (MEDICAL SOCIOLOGY) Course director: DR. ZSUZSANNA FÜZESI, associate professor Department of Behavioural Sciences 2 credit Elective spring semester midsemester grade Number of hours/semester (lect. + pract. + semin): = 28 Headcount limitations: 1 50 course code prerequisite 1 prerequisite 2 prerequisite 3 rec. semester GENMED DENT OSESZO none PHARM Topic Medical sociology deals with the sociological and behavioral factors influencing the health status and health care. Acquiring the theoretical and practical basis of sociology at this course, students will be able to realize and understand the basic patterns of behavior in maintenance of health, in the development of illness, and in the process of treatment and care in the context of the society. Main research issues of sociology: epidemiology of chronic diseases; health and illness behavior; sociological-economical aspects of health care; models of development in health care; alternative medicine Conditions for acceptance of the semester According to the Code of Studies and Examinations. Making up for missed classes -- Reading material D. Armstrong: An Outline of Sociology as Applied to Medicine, 4th edition. Wright, London, 1994 Lectures 1. Introduction. Sociological approaches to health and medicine Introduction. Sociological approaches to health and medicine 2. Introduction. Sociological approaches to health and medicine 3. Illness behaviour 4. Illness behaviour 5. Measuring health and illness 6. Measuring health and illness 7. Social causes of illness 8. Social causes of illness 9. Labeling behaviour 10. Labeling behaviour 11. Inequalities in health 24

25 12. Inequalities in health 13. Coping with illness 14. Coping with illness 15. Models of illness 16. Models of illness 17. Types of health care 18. Types of health care 19. Clinical autonomy 20. Clinical autonomy 21. Delivering health care 22. Delivering health care 23. Evaluating health care 24. Evaluating health care 25. Social basis of disease 26. Social basis of disease 27. Social role of medicine 28. Social role of medicine Practices Seminars Exam topics/questions Semester grade: Written multiple choice test, about questions. Knowledge basis for written test: Reference book and handout of lectures (format:.ppt,.pdf). Further details can be read at the homepage of the Institute of Behavioural Sciences: 25

26 BIOINORGANIC CHEMISTRY Course director: DR. GYULA TÓTH, professor emeritus Department of Biochemistry and Medical Chemistry 2 credit Elective spring semester midsemester grade Number of hours/semester (lect. + pract. + semin): = 28 Headcount limitations: 1 80 course code prerequisite 1 prerequisite 2 prerequisite 3 rec. semester GENMED OAEBSK OAAOK DENT OSEBSK OSAOK PHARM Topic The course deals with biological importance of elements (metals and nonmetals) in the living organisms discussing the effects of common toxic elements. Basic respect of studying the interaction of ions, molecules and biopolymers. It gives a basic knowledge and facilitates to understand certain chapters of medical biochemistry. Conditions for acceptance of the semester Successful written examination. Making up for missed classes None. Reading material P. Gergely (Ed.): Introduction to Bioinorganic Chemistry for Medical Students (Univ. Med. School of Debrecen, latest edition) Wolfgang Kaim, Brigitte Schwederski: Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life (Wiley, latest edition) Lectures 1. Introduction to bioinorganic chemistry I. 2. Introduction to bioinorganic chemistry II. 3. Structure of biocomplex compounds 4. Chelates 5. Life essential elements 6. Evolution of inorganic chemicals 7. Evolution of organic chemicals 8. Uptake of metallic elements 9. Uptake of anions, molecules 10. Biological importance of alkali metals 11. Biological importance of alkaline earth metals 12. Bioinorganic chemistry of Fe-ions 26

27 13. Bioinorganic chemistry of Cu-ions 14. Bioinorganic chemistry of Zn-ion 15. Bioinorganic chemistry of transition metals I. 16. Bioinorganic chemistry of transition metals II. 17. Bioinorganic chemistry of transition metals III. 18. Test Paper I. 19. Biological role of aluminium 20. Biological role of silicon 21. Function of nitrogen in biological systems 22. Function of phosphorus in biological systems 23. Dioxygen, oxygen free radicals I. 24. Dioxygen, oxygen free radicals II. 25. Boron, Selenium 26. Arsenic and other non-metallic elements 27. Biological functions of halogenes 28. Test Paper II. Practices Seminars Exam topics/questions nu=okt_anyag 27

28 BIOMETRICS AND COMPUTING Course director: 2 credit Elective fall semester midsemester grade Number of hours/semester (lect. + pract. + semin): = 28 Headcount limitations: 1 0 DR. LÁSZLÓ PÓTÓ, associate professor Institute of Bioanalysis course code prerequisite 1 prerequisite 2 prerequisite 3 rec. semester GENMED DENT OSEMET PHARM Topic As a first course in statistics it covers the following main blocks: Basic data handling and computer use. Exploring data by graphical and numerical characterisation. Basic concepts of probability and statistical inference. The basic methods for statistical inference most frequently used in medicine. As the main goal it focuses on the power of statistical thinking that is new to students and increasingly important at medical field. Conditions for acceptance of the semester two written test, no more than two missed classes Making up for missed classes extra class Reading material Issued by the Institute: J. Belágyi: Medical Statistics. Lecture notes, Pécs, L. Pótó: Biometrics. Workbook for the Practices, Pécs, Handouts and worksheets. Textbooks: 1, Moore, D. S. The Basic Practice of Statistics, 3rd Ed., or 2, Moore, David S., McCabe, George P. Introduction to the Practice of Statistics 5th Ed, 2005, W.H. Freeman and: Yates, Dan, Moore, David S., Starnes, Daren S. The Practice of Statistics (TI-83/89 Graphing Calculator Enhanced) 2/e, 2003, W.H. Freeman or 3, Rees, W. G. Essential Statistics, Chapman and Hall,

29 Lectures 29. Introduction (Statistics in medicine, models). Probability. 30. Variables, Discrete distributions (binomial and Poisson). 31. Continuous variables. Histogram, relative frequency density and probability density function. 32. Mean and standard deviation. The normal distribution. 33. Distribution of the sample mean, standard error. 34. Confidence interval for the expected value. The t distribution 35. Principle of hypothesis testing. The one sample and the paired samples t tests. The sign test (preview). 36. The confidence interval and the hypothesis testing. Type I and type II errors. 37. The independent samples t test. The F test. 38. Linear regression and correlation. 39. Contingency tables 1. The chi-squared test. 40. The non-parametric tests (sign test, Wilcoxon and Mann-Whitney tests). 41. The principle of the ANOVA. Summary of the hypothesis testing methods. 42. Medical tests. Sensitivity and specificity. (Contingency tables 2.) Summary. Practices 29. Probability examples 1. + Using computers, Windows, SPSS. 30. Probability examples 2 - discrete distributions. 31. The binomial distribution. 32. Exploring data by graphs. Continuous variables. Histogram. 33. Exploring data by numbers - descriptive statistics 34. Normal distribution. The distribution of the sample mean. 35. Estimations. The confidence interval of the expected value. 36. The hypothesis testing - the five steps. The one sample (and the paired samples) t tests. The sign test. 37. Estimation and hypothesis testing. The Type one and Type two errors. 38. The independent samples t test. 39. The linear regression and correlation. 40. Contingency tables - the chi-squares test. 41. Nonparametric tests (Sign test, Wilcoxon tests, Mann-Whitney test) 42. Summary Seminars 29

30 Exam topics/questions 1. The main goal of biometrics/biostatistics Compare the two models - what are the main differences? Relate them and show how they both have it s role in the scientific work and in medicine. (mainly from the lectures 1, 3, and 6-7-8) 2. The key feature of the statistical thinking - the probability Show this term - use a simple example, please. When can it be (and when can not) calculated? Illustrate using some examples how both way can be used in practical medical situations. (mainly from the lectures 1, 2, and 12) 3. The idea of the probability distribution - discrete distributions - 1, Demonstrate on the example of the binomial distribution how the probability calculations (games of chances case) can be used in real life situations. How can you illustrate a distribution (graphically). Trace it s role on the decision making. (mainly from the lectures 2, and 12) 4. The idea of the probability distribution - discrete distributions - 2, Contrast the binomial and the Poisson distributions: similarities and differences - demonstrated by some examples. Show the importance of discrete distributions trough examples. (Which hypothesis testing methods are based on this approximation?) (mainly from the lectures 2, and 12) 5. The basic principles of statistical thinking - from the data to the decision The way to the decision - and some pitfalls. (size of the sample, representativity, lurking variables, probability decision, risk of errors, - and handling them) (mainly from the lectures 3 and 6-7-8) 6. Types of the data (variables) and displaying them with graphs The three most frequent types of data and the methods for summarizing and displaying them. Applications of some diagrams - strength and weaknesses. What specific info can be observed from a given type of graph? When to choose a given type? (mainly from the lecture 3 and 10) 7. The population and the sample Explain both terms in case of some different types of data. How to characterize (by pictures or numbers) the sample and the population in these examples? Discuss the basic role of both terms in the statistical inference and decision making (mainly from the lectures 2, 3, and 12) 30

31 8. Numerical description of continuous data Contrast the five number and three number descriptions. When to use one and when the other? Prove and demonstrate by examples the basic role of the two description while selecting the appropriate decision making (or hypothesis testing) method. (mainly from the lectures 4, and 12) 9. The idea of the probability distribution - continuous distributions Symmetrical and skewed distributions. How the measures of the sample show (mirror) the shape of the distribution? Demonstrate them on the example of the normal and some skewed distributions. Prove the importance of distinction between them (think to the condition of the decision making methods). (mainly from the lectures 4, and 12) 10. The normal distribution 1 Features. Why is it so frequently used in biology and medicine? Application examples (reference range,...). How does the normal approximation method demonstrate its importance (application examples)... and how does the conditions of the hypothesis testing methods? (mainly from the lectures 4, 5, and 12) 11. The normal distribution 2 How the distribution of the mean shows its importance? Verify the basic role of the distribution of the mean while statistical inference and decision making. (mainly from the lectures 4, 5, ) 12. Statistical inference The statistical inference is the main goal (final step) of the statistical thinking. Contrast the point- and the interval estimation from this point of view. Trace both methods (and the use of them) on the example of the confidence interval for the expected value (the p% CI of the expected value). (mainly from the lectures 5 and 6) 13. The confidence interval of the population mean You can find the 95% CI on most of the SPSS output (that you learned). What is that and why can you meet it so frequently at statistical analysis? Give examples of results screens (methods): why is it included in the given method - what is the use of it there? (mainly from the lectures 5 and 6 - and all the lectures from then) 31

32 14. The basic idea of hypothesis testing Prove the relevance of the five steps method - and demonstrate it on everyday and medical examples. What are the simple given steps of the five and those that are require personal evaluation from case to case? Discuss these later ones on examples. (mainly from the lectures 7 - and all the lectures from then) 15. The one sample and the paired t test At what kind of data (-structure) should you use this method when hypothesis testing? Relate the two methods to each other. What can be done when the application conditions do not fit? Why not use these later methods at all the situations than? (mainly from the lectures and 12) 16. The confidence interval and the hypothesis testing Contrast the two methods: similarities and differences - strength and weaknesses. Demonstrate your evaluation on examples. (mainly from the lectures 6-7-8) 17. The risk of errors and the power of a test Discuss the essential feature of the statistical decisions the risk of errors. How can you handle these risks? When should you handle these risks? Explain on examples: when can you use the value of the risk of a certain error and when to use the power of the test? (Which questions call for this kind of answers?) (mainly from the lectures 8 and 9) 18. The two (independent) samples t test Contrast the paired and independent samples t tests? What are the typical questions which call for the later method? What is the specific requirement (condition) of this method - and how can you handle this with the help of the F test? (What should we pay for that solution? Why not to use always the solution which has less requirements?) (mainly from the lecture 9) 19. Connection between two variables - continuous variables Contrast the one variable - two samples and the two variables - paired data ( one sample ) cases. What are the typical questions in the two cases? Use examples to explain the method of the linear regression and correlation analysis. Stress the steps where there is an obvious role of statistical thinking. Is this method a hypothesis test? (mainly from the lecture 10) 32

33 20. Connection between two variables - categorical variables Relate to each other the two variables methods for continuous and categorical variables - similarities and differences. Which numbers are to be evaluated in the later case? Which hypothesis testing method(s) are available for that? Explain the five steps on an example. What are the conditions for applying the method(s) and what to do when those conditions are not valid? (mainly from the lectures 11 and 12) 21. Evaluation of frequency data - 1. Why the chi-squares test is not applicable in the medical practice frequently? What to do then? When to use the Fisher s exact test - out of those cases? What the exact word means in the name? (mainly from the lectures 11 and 12) 22. Evaluation of frequency data - 2. How to qualify a diagnostic test? Which questions can be answered by the sensitivity, specificity and the predictive value(s) of the test? The confidence interval for the proportion. Explain (using the previous term) why the chisquares test gives not significant result at evaluations of medical data frequently. (mainly from the lectures 11 and 12) 23. Nonparametric tests - 1. When to refuse the application of a t test - and when to apply the sign test instead? Demonstrate the five steps on an example using the sign test. Contrast this method and the appropriate parametric one? What are the strength and weaknesses of this method? (mainly from the lectures 2, 7 and 12) 24. Nonparametric tests - 2. When to refuse the application of a t test - and when to apply the Wicoxon and the Mann- Whitney test instead? Demonstrate the application of both tests on examples. Contrast these methods and the appropriate parametric ones? What are the strength and weaknesses of these methods? (mainly from the lectures 2, 9 and 12) 25. The principle of the ANOVA Demonstrate the application of the ANOVA method on an example What is the basic idea of the evaluation? Illustrate it on the case of comparing several group means simultaneously. What is the strength of this method in contrast to the several t tests for pairs of groups? (mainly from the lectures 2, 8, 9 and 13) 33

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35 BIOPHYSICAL BASIS OF DIAGNOSTIC AND THERAPEUTIC METHODS Course director: DR. GÁBOR HILD, associate professor Department of Biophysics 2 credit Elective spring semester midsemester grade Number of hours/semester (lect. + pract. + semin): = 28 Headcount limitations: 5 25 course code prerequisite 1 prerequisite 2 prerequisite 3 rec. semester GENMED OAEDMB OAABI2 OAAEL2-6 DENT OSEDMB OSABI2 OSAEL2-6 PHARM Topic The course addresses the physical and biophysical basis of modern diagnostic and therapeutic methods employed in current medical practice. Conditions for acceptance of the semester Maximum of three absences. Making up for missed classes None. Reading material Lectures Practices Seminars 1. Introduction 2. Generation and properties of ultrasound 3. Diagnostic and therapeutic applications of ultrasound 4. Generation, properties, detection and absorption of X-rays 5. Diagnostic X-ray. Computed tomography (CT) 6. Isotopes, radioactive radiations 7. Gamma-camera, SPECT 8. Biological effects of radioactive radiations. Principles and applications of radiation therapy 9. Positron emission tomography (PET) 10. Applications of PET 11. Physical basis of magnetic resonance 12. MRI 13. Optical fibers and endoscopy. Optical microscopy in medical diagnostics 14. Electron microscopy, fluorescence and confocal microscopy 35

36 15. Properties, absorption and biological effects of laser 16. Medical applications of laser. Photodynamic therapy 17. Absorption photometry and fluorescence spectroscopy 18. Theoretical basis of mass spectrometry 19. Applications of mass spectrometry 20. Physical basis of flow cytometry and cell sorting 21. Diagnostic applications of flow cytometry 22. Physical basis of kidney dialysis 23. Physical basis of electrophysiological methods (EKG, EEG, EMG) 24. Physical therapy 25. Galvanometric methods, diathermy 26. Basic physics and measurement in the everyday medical practice Basic physics and measurement in the everyday medical practice Test Exam topics/questions Can be found on the departmental website ( 36

37 CARDIAC SURGERY Course director: 1 credit Elective both semesters midsemester grade Number of hours/semester (lect. + pract. + semin): = 13 Headcount limitations: DR. SÁNDOR SZABADOS, associate professor Heart Institute course code prerequisite 1 prerequisite 2 prerequisite 3 rec. semester GENMED OAESSE OAPPA1 OAPPA2 OAPKO2 9 DENT PHARM Topic The aim of this course is to delineate the most common surgical cardiac diseases. We lay emphasis on coronary heart disease and coronary artery bypass surgery. The surgical treatment of aortic dissection, cardiac failure, atrial fibrillation, cardiac tumors, pericardial and valvular diseases are also subjects of the lectures and the seminars. We also delineate the special technique of cardiopulmonary bypass, myocardial protection and hypothermia. Conditions for acceptance of the semester Active attendance at classes, no more than 3 absences Making up for missed classes On individual cases, on agreement Reading material 1. Klinikai kardiológia, 3. bővített kiadás, Szerkesztő: Dr. Tomcsányi János, Medintel Könyvkiadó, Kirklin-Barratt-Boyes - Cardiac Surgery - Morphology, Diagnostic Criteria, Natural History, Techniques, Results and Indications, John Wiley & Sons, USA, 3. L. Henry Edmunds, Jr., MD. - Cardiac Surgery in the Adult Braunwald: Heart Disease - A Textbook of Cardiovascular Medicine, 6th edition, Saunders Company, USA, Szívsebészet jegyzet, Pécs 2009 Lectures 1. Surgical therapy for valvular heart disease 2. Surgery for heart failure. Surgery for atrial fibrillation 3. Pericardial diseases. Cardiac tumors. Aorta atherosclerosis, aneurysm, dissection. Traumatic injuries of the heart and great arteries 4. Brief history of cardiac surgery. Basic considerations 5. Extracorporeal circulation, hypothermia, myocardial protection 6. Congenital cardiac surgery

38 7. Surgery for ischemic heart disease Practices 1. Operative technique, instruments, suturing on phantom 2. Introduction, personal and technical conditions of cardiac surgery 3. Introduction, personal and technical conditions of cardiac surgery 4. Examination, preparation and postoperative follow-up of the patients with coronary and valvular heart disease 5. Examination, preparation and postoperative follow-up of the patients with coronary and valvular heart disease 6. Operative technique, instruments, suturing on phantom Seminars Exam topics/questions Basic considerations Extracorporeal circulation, hypothermia, myocardial protection Congenital cardiac surgery Surgery for ischemic heart disease Surgical therapy for valvular heart disease Surgery for heart failure. Surgery for atrial fibrillation Pericardial diseases. Cardiac tumors. Aorta atherosclerosis, aneurysm, dissection. Traumatic injuries of the heart and great arteries 38

39 CASES IN CLINICAL RADIOLOGY Course director: 1 credit Elective spring semester midsemester grade Number of hours/semester (lect. + pract. + semin): = 14 Headcount limitations: DR. ISTVÁN BATTYÁNY, associate professor Department of Radiology course code prerequisite 1 prerequisite 2 prerequisite 3 rec. semester GENMED OAERAM OAKKRA OAKSE2-8 DENT PHARM Topic 14 lessons, all of them are practices, (one hour per week) (one by groups per week). The practices are enclosed. Clinical and differential diagnostical application of the learn knowledge. The students have to analyse the prepared cases during the practice. They have to find the best diagnostic algorithm and the final exact diagnosis. The cases simulate the real life diseases. Conditions for acceptance of the semester To get the index book signed, a maximum of 4 (four) seminars (4 hours) may be missed and they are not replaceable by any kind, even by participating in others seminar, since the subjects may go non-parallel in various groups. Missed seminars, caused by disease, can be certified by a written certificate obtained from the treating physician (booked in the log of his/her office)! This can be done at the next seminar on the forthcoming week, only. Making up for missed classes None Reading material In English: - P. Scally: Medical Imaging. Oxford University Press, Oxford, R. B. Gunderman: Essential Radiology. Thieme, G. M. Roberts, J. P. Hughes, and M. D. Hourihan: Clinical Radiology for Medical Students - S. Francis, A. F. Watkinson (Department of Radiology The Royl Free Hospital, London, UK): Interventional Radiology explained. REMEDICINA Publishing, In Hungarian: - Fráter, Palkó, Makó, Kollár, Battyáni: Radiológia (Medicina, 2003) Recommended: Daffner, Richard H.: Cilinical Radiology: The Essentials, Williams & Wilkins, 1993

40 Davit Sutton: Textbook of Radiology and Imaging (7 th edition), ELSEVIER Lectures Practices 7. Clinical cases I. 8. Clinical cases II. 9. Clinical cases III. 10. Clinical cases IV. 11. Clinical cases V. 12. Clinical cases VI. 13. Clinical cases VII. 14. Clinical cases VIII. 15. Clinical cases IX. 16. Clinical cases X. 17. Clinical cases XI. 18. Clinical cases XII. 19. Clinical cases XIII. 20. Clinical cases XIV. Seminars Exam topics/questions To know about and to know to use all the knowledge learned so far in every subject of medicine. To apply the learned clinical radiological knowledge using prepared clinical cases. 40

41 CHEMISTRY OF BIOACTIVE ORGANIC COMPOUNDS Course director: DR. GYULA TÓTH, professor emeritus Department of Biochemistry and Medical Chemistry 2 credit Elective spring semester midsemester grade Number of hours/semester (lect. + pract. + semin): = 28 Headcount limitations: 1 0 course code prerequisite 1 prerequisite 2 prerequisite 3 rec. semester GENMED OAEBVK OAAOK DENT OSEBVK OSAOK PHARM Topic The course discusses the chemical and biological properties of the vitamins, some alkaloids and the more important antibiotics. In the case of antibiotics as a major goal, the program affords a short overview of the structure biological effect relationships and the biochemical mechanism of action. It gives a basic knowledge and helps in the understanding of the later subjects such as biochemistry, microbiology, as well as pharmacology. Conditions for acceptance of the semester Successful written examination. Making up for missed classes None. Reading material P. Gergely (Ed.): Organic and Bioorganic Chemistry for Medical Students (Univ. Med. School of Debrecen, latest edition) Lubert Stryer: Biochemistry (W.H. Freeman and Co., latest edition) Lectures 1. General overview of nutrients I. 2. General overview of nutrients II. 3. General overview of the vitamins 4. General overview of the provitamins 5. The history of vitamin research I. 6. The history of vitamin research II. 7. Fat soluble vitamins I: A- and D-vitamins 8. Fat soluble vitamins II: E- and K-vitamins 9. Water soluble vitamins 10. Vitamin C 11. B-group vitamins 41