CURRICULUM VITAE JASON M. SHAPIRO, MD

Transcription

1 CURRICULUM VITAE JASON M. SHAPIRO, MD Division of Pediatric Gastroenterology, Nutrition and Liver Diseases Hasbro Children s Hospital Rhode Island Hospital 593 Eddy Street, MPH 112 Providence, Rhode Island (401) JShapiro@lifespan.org Liver Research Center Rhode Island Hospital 55 Claverick Street Room 113 Providence, Rhode Island (401) Jason_Shapiro@Brown.edu EDUCATION Undergraduate Medical School POSTGRADUATE TRAINING Residency Fellowship 2001 University of Vermont, Burlington, Vermont B.A in Biology, minor in Chemistry Graduated cum laude, Dean s List, John Dewey Scholar, Honors Senior Thesis in Neuroscience M.D University of Vermont College of Medicine, Burlington, Vermont Member, Alpha Omega Alpha Intern and Resident, Department of Pediatrics Hasbro Children s Hospital/Rhode Island Hospital The Warren Alpert Medical School of Brown University Providence, Rhode Island July 2005 June 2008 Fellow in Pediatric Gastroenterology, Hepatology and Nutrition Division of Pediatric Gastroenterology, Nutrition and Liver Diseases, Hasbro Children s Hospital/Rhode Island Hospital The Warren Alpert Medical School of Brown University Providence, Rhode Island July 2008 June 2011 PROFESSIONAL LICENSES AND BOARD CERTIFICATION Rhode Island Department of Health (Certificate #MD12750, July 9, 2008) American Board of Pediatrics 1

2 General Pediatrics (Certificate # , October 27, 2008) American Board of Pediatrics Pediatric Gastroenterology, Hepatology and Nutrition (Certificate # 1246, November 15, 2011) ACADEMIC APPOINTMENTS HOSPITAL APPOINTMENTS Assistant (Clinical) Professor of Pediatrics, The Warren Alpert Medical School of Brown University, July present. Attending Physician, Division of Pediatric Gastroenterology, Nutrition and Liver Diseases, Rhode Island Hospital/Hasbro Children s Hospital, July present. Consulting Physician, Department of Pediatrics, Women&Infants Hospital of Rhode Island, July present. OTHER APPOINTMENTS Pediatric House Officer Landmark Medical Center, Woonsocket, Rhode Island April 2008 February Reviewer, Inflammatory Bowel Diseases. April 2015-Present. Reviewer, Digestive Diseases and Sciences. March 2015-Present. Reviewer, Journal of Pediatric Gastroenterology, Hepatology and Nutrition, November Present. Ad hoc reviewer, Journal of Pediatric Gastroenterology, Hepatology and Nutrition. July 2009 November Ad hoc reviewer, Pediatrics, November 2009 Present. UNIVERSITY COMMITTEES Faculty Search Committee, Division of Pediatric Gastroenterology, Nutrition and Liver Diseases. Warren Alpert Medical School of Brown University. January 2015 February Faculty Search Committee. Division of Pediatric Hematology and Oncology. Warren Alpert Medical School of Brown University. April 2014 October

3 Chair, Pediatric Gastroenterology Fellowship Research Committee. Fellowship in Pediatric Gastroenterology, Nutrition and Liver Diseases. Warren Alpert Medical School of Brown University, February 2012 Present. Fellowship Committee, Fellowship in Pediatric Gastroenterology, Nutrition and Liver Diseases. Warren Alpert Medical School of Brown University, July Fellowship Curriculum Taskforce, Fellowship in Pediatric Gastroenterology, Nutrition and Liver Diseases. Warren Alpert Medical School of Brown University, April Observed Structured Clinical Examination (OSCE). Faculty reviewer of third year medical students at Warren Alpert Medical School of Brown University. July 2011-Present. MEMBERSHIP IN SOCIETIES Crohn s and Colitis Foundation of America (CCFA), December Present. American Gastroenterological Association (AGA), April 2012 Present. North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN), July 2008 Present. American Academy of Pediatrics (AAP), July 2005 June RESEARCH Ocean State Crohns and Colitis Area Registry (OSCCAR) (CDC U01-DP ). Participated in early phases of this prospective, community-based cohort study evaluating the natural history of inflammatory bowel disease in the state of Rhode Island. Actively involved as co-investigator in all current clinical and translational sub-studies. Recently appointed Site Principal Investigator at Rhode Island Hospital. Principle Investigator: Bruce E. Sands, MD. Pediatric Inflammatory Bowel Disease Biobehavioral Registry. Co-investigator active in substudy design, data abstraction and manuscript preparation. Principal Investigators: Neal LeLeiko, MD, PhD, Debra Lobato, PhD. Predicting Response to Standardized Pediatric Colitis Therapy (PROTECT). Site Co-Principal Investigator. January 2014-Present. Risk Stratification: An Inception Cohort Study of Pediatric Onset Crohn s Disease. Site Co- Principal Investigator. January 2014-Present. Attention and Memory in Obese Children with Non-Alcoholic Fatty Liver Disease. Coinvestigator and faculty advisor. NIH T32 funding provided our current GI fellow, Vania Kasper, to work on this project under the mentorship of Suzanne de la Monte, MD. NIH Ruth L. Kirschstein National Research Service Award (T32DK ). Postdoctoral Fellow, Dr. Jack Wands, Advisor. Department of Gastroenterology, Liver Research Center. The Warren Alpert Medical School of Brown University. Translational research investigating novel biomarkers of colonic dysplasia, January 2010 December 31,

4 Astrocyte damage and Niemann-Pick Type C Disease. Undergraduate College Honors Thesis, University of Vermont, Cynthia Forehand, PhD advisor ORIGINAL PUBLICATIONS IN PEER-REVIEWED JOURNALS Shapiro JM, Kerur B. Do Orally Administered Immunoglobulin-Based Agents Represent the Future of IBD Therapeutics? Digestive Diseases and Sciences 2015; epub ahead of print. PMID Shapiro JM, Cho JH, Sands BE, LeLeiko NS. Bridging The Gap Between Host Immune Response and Intestinal Dysbiosis in Inflammatory Bowel Disease: Does Immunoglobulin A Mark the Spot? Clinical Gastroenterology and Hepatology 2015;13(5): PMID: Townsend P, Zhang Q, Shapiro JM, Webb-Robertson BJ, Bramer L, Schepmoes AA, Weitz KK, Mallette M, Moniz H, Bright R, Kamphaus T, Shah SA, Sands BE, LeLeiko NS. Serum Proteome Profiles in Stricturing Crohn s Disease: A Pilot Study. Inflammatory Bowel Diseases 2015;21(8): PMID Krishnarao A, de Leon L, Bright R, Moniz H, Law M, LeLeiko N, Sands BE, Merrick M, Flowers N, Shapiro J, Wallenstein S, Giacalone J, Shah SA. Testing for Clostridium difficile in Patients With Newly Diagnosed Inflammatory Bowel Disease in a Community Setting. Inflammatory Bowel Diseases 2015;21(3): PMID: Saha S, Zhao YQ, Shah SA, Degli-Esposti SD, Lidofsky S, Shapiro J, Bright R, Law M, Moniz H, Samad Z, Merrick M, Sands B. Body Image Dissatisfaction in Patients with Inflammatory Bowel Disease. Inflammatory Bowel Diseases 2015;21(2): PMID: Reed-Knight B, Lobato D, Hagin S, McQuaid E, Nassau J, Boergers J, Seifer R, Soursa K, Bancroft B, Shapiro J, LeLeiko, N. Depressive Symptoms in Youth with Inflammatory Bowel Disease Compared to a Community Sample. Inflammatory Bowel Diseases 2014;20(4): PMID: LeLeiko NS, Lobato D, Hagin S, Hayes C, McQuaid EL, Seifer R, Kopel SJ, Boergers J, Nassau J, Soursa K, Shapiro J, Bancroft B. 6-Thioguanine Levels in Pediatric IBD Patients: Adherence is More Important Than Dose. Inflammatory Bowel Diseases 2013; 19(12): PMID: LeLeiko N, Lobato D, Hagin S, McQuaid E, Seifer R, Kopel S, Boergers J, Nassau J, Soursa K, Shapiro J, Bancroft B. Rates and Predictors of Oral Medication Adherence in Pediatric IBD Patients. Inflammatory Bowel Diseases 2013; 19(4): PMID: Shapiro J, Kawatu D, Bancroft B, LeLeiko N. Inflammatory Bowel Disease in Pediatrics. Medicine and Health Rhode Island 2009 Apr;92(4):135, PMID: OTHER PEER-REVIEWED PUBLICATIONS Shapiro J, LeLeiko, NS. New Guidelines for Diagnosis and Treatment of C difficile. AAP Grand Rounds 2013; 30(5):60. 4

5 BOOKS AND BOOK CHAPTERS Shapiro J, LeLeiko N, Pinkos B. Enteral Nutrition, Pediatric Gastrointestinal and Liver Disease, 5 th Edition. In Press. PUBLICATIONS IN PREPARATION Shapiro JM, Zoega H, Shah SA, Bright R, Mallette M, Moniz H, Grabert SA, Bancroft B, Flowers NT, Lidofsky S, Samad Z, Merrick M, LeLeiko NS, Sands BE. Incidence of Crohn s Disease and Ulcerative Colitis in Rhode Island: Report from the Ocean State Crohn s and Colitis Area Registry (OSCCAR). Submitted July Mao E, Shapiro JM, Giacalone J, Sands B, LeLeiko N, Wallenstein S, Princen F, Singh S, Lockton S, Bright R, Law M, Moniz H, Merrick M, Shah S. Sensitivity, Specificity and Stability of Seromarkers in a Prospective Community-Based Inception Cohort of Newly-Diagnosed. Submitted June Grand D, Harris A, Shapiro JM, Wu E, Engels M, Giacalone J, Shah S, LeLeiko N, Bright R, Law M, Moniz H, Merrick M, Sands B. Radiation Exposure to the Abdomen and Pelvis in Patients Newly Diagnosed with Inflammatory Bowel Disease. Submitted July Shapiro JM, Subedi S, Machan JT, Cerezo CS, Ross AR, Shalon LB, Silverstein JA, Herzlinger MI, Kasper V, LeLeiko NS. Durability of Infliximab is Associated with Disease Extent in Children with Inflammatory Bowel Disease. In preparation. Herzlinger M, Shaolei L, Matoso A, Noble L, Cao W, Yang D, Shapiro JM, Kurtis J, LeLeiko N, Resnick M. 15(S)-HETE: A Novel Serological Biomarker for Eosinophilic Esophagitis? In preparation. Shapiro JM, Menz T, Herzlinger M, Cerezo C, Silverstein J, Shalon L, LeLeiko N. Variations in Diagnosis and Management of Intra-Abdominal Abscesses in Pediatric Crohn s Disease: A 10 Year Single-Center Retrospective Review. In preparation. Shapiro JM, Carlson R, Chung W, Li J, Resnick M, Wands J. Identification of the Tumor- Associated Antigen AF-20 as a Glycosylated Transferrin Receptor in Complex with Heat Shock Protein 90 and Transporting ATPase. In preparation. PRESENTED ABSTRACTS Townsend P, Zhang Q, Shapiro JM, Webb-Robertson BJ, Bramer L, Schepmoes AA, Weitz KK, Mallette M, Moniz H, Bright R, Kamphaus T, Shah SA, Sands BE, LeLeiko NS. Differential Protein Expression Profiles in Stricturing Crohn s Disease. Accepted for Poster Presentation at DDW Shapiro J, Hagin S, Sands B, LeLeiko N, Bright R, Law M, Moniz H, Giacalone J, Merrick M, Shah S. Corticosteroid Use in a Prospective, Community-Based Cohort of Newly Diagnosed Inflammatory Bowel Disease Patients. Crohn s and Colitis Foundation of America s Advances in 5

6 Inflammatory Bowel Disease Clinical and Research Conference. Hollywood, FL, December 15, Mao E, Shapiro J, Giacalone J, Sands B, LeLeiko N, Wallenstein S, Princen F, Singh S, Lockton S, Bright R, Law M, Moniz H, Merrick M, Shah S. Sensitivity, Specificity and Stability of Seromarkers in a Prospective Population-Based Inception Cohort of Newly-Diagnosed Inflammatory Bowel Disease. Oral Presentation, American College of Gastroenterology Annual Meeting, San Diego, CA, October 13, Wu E, Engels M, Grand D, Harris A, Giacalone J, Shah S, Shapiro J, LeLeiko N, Bright R, Law M, Moniz H, Merrick M, Sands B. Radiation Exposure to the Abdomen and Pelvis in Patients Newly Diagnosed with Inflammatory Bowel Disease. American College of Gastroenterology Annual Meeting, San Diego, CA, October 13, Kasper V, Shapiro J, Cerezo C, Wallach M, LeLeiko N. Medical Management of Crohn s Appendicitis. NASPGHAN Annual Meeting. Chicago, IL, October 11, Herzlinger M, Shapiro J, Mukkada M, Cerezo C, Grand D, LeLeiko N. Medical Management of Crohn s Disease Complicated by Enterovesical Fistula and Intra-Abdominal Abscess. NASPGHAN Annual Meeting. Salt Lake City, UT, October 19, 2012 Shapiro J, Cerezo C, Silverstein J, Shalon L, LeLeiko N. Intra-abdominal Abscesses in Pediatric Crohn s Disease: Management and Outcomes. Crohn s and Colitis Foundation of America s Advances in Inflammatory Bowel Disease Clinical and Research Conference. Hollywood, FL, December 14, LeLeiko N, Lobato D, Hagin S, Hayes C, McQuaid E, Siefer R, Kopel S, Boergers J, Nassau J, Shapiro J, Soursa K, Bancroft B. 6-TGN Levels in Pediatric IBD Patients: Adherence in More Important Than Dose. Crohn s and Colitis Foundation of America s Advances in Inflammatory Bowel Disease Clinical and Research Conference. Hollywood, FL, December 14, Hagin S, Lobato D, Shapiro J, Nassau J, McQuaid E, Seifer R, Kopel S, Boergers J, Soursa K, Bancroft B, LeLeiko N. Physical Activity and Health Outcomes in Pediatric Inflammatory Bowel Disease. Crohn s and Colitis Foundation of America s Advances in Inflammatory Bowel Disease Clinical and Research Conference. Hollywood, FL, December 14, Hayes C, Hagin S, Lobato D, McQuaid E, Kopel S, Soursa K, Boergers J, Seifer R, Bancroft B, Nassau J, Shapiro J, Cai A, LeLeiko N. Patterns of Non-Adeherence to Medications in Pediatric Patients with IBD. NASPGHAN Annual Meeting, Orlando, FL, October 20, Shapiro JM, Carlson RI, Resnick MB, Wands JR. Potential New Biomarkers of Colonic Dysplasia in Ulcerative Colitis Screening. Crohn s and Colitis Foundation of America s Advances in Inflammatory Bowel Disease Clinical and Research Conference. Hollywood, FL, December 10,

7 Shapiro JM, Carlson RI, Resnick MB, Wands JR. Novel Biomarkers of Colonic Dysplasia. NASPGHAN Annual Meeting, New Orleans, LA, October 23, Shapiro JM. Astrocyte Damage and Niemann-Pick Type C Disease. Poster Presentation given at N.E.U.R.O.N (Northeast Undergraduate Research Organization for Neuroscience) annual meeting held at Wellesley College. May HONORS AND AWARDS Bright Lite Nominee. Hasbro Children s Hospital National Institute of Health, NIDDK. Travel Grant to attend the single topic symposium, Discovering the Future of Pediatric Inflammatory Bowel Disease Care at North American Society of Pediatric Gastroenterology, Hepatology and Nutrition annual meeting. October 17, North American Society of Pediatric Gastroenterology, Hepatology and Nutrition, Teaching and Tomorrow Travel Grant, October American Academy of Pediatrics Resident Scholarship, Alpha Omega Alpha, 2005, University of Vermont College of Medicine Freeman Scholarship, 2004, University of Vermont College of Medicine John Dewey Scholar, 2001, University of Vermont. Successfully defended thesis entitled Astrocyte Damage and Niemann-Pick Type C Disease Phi Beta Kappa, 2000, University of Vermont. One of four members of the class of 2001 to be inducted during junior year Golden Key National Honor Society, 1999, University of Vermont Simon Family Scholarship, , University of Vermont. $13,000/year scholarship awarded to one out-of-state student per year based on academic merit and devotion to community service. INVITED LECTURES Pediatric IBD: What Parents Need to Know. Crohn s and Colitis Foundation of America. Rochambeau Library, Providence, Rhode Island December 2, Congenital Diarrhea in a Neonate. Clinico-Pathologic Conference. Women and Infants Hospital, Division of Neonatology. Providence, Rhode Island November 21, The Delicate Balance of Gut Inflammation: Inflammatory Bowel Disease and Necrotizing Enterocolitis. 7 th Annual Neonatal~Pediatric Gastroenterology Summit, Crowne Plaza, Warwick, Rhode Island, March 22,

8 Inflammatory Bowel Disease in Pediatrics. Housestaff Lecture, University of Vermont College of Medicine/Vermont Children s Hospital, August 31, Pediatric Liver Transplant Case Conference. Presented an evidence-based review of indications for pediatric liver transplant. Regional meeting with faculty and staff of Pediatric GI at Brown University and Transplant Hepatology division of Yale-New Haven Children s Hospital. September 17, HOSPITAL TEACHING ROLES Pediatric Gastroenterology Fellow Core Curriculum. Multiple lectures on basic GI physiology and pathophysiology presented each year. Topics have included Infectious Diarrhea, GI Embryology, Neonatal Cholestasis, Mucosal Immunology. July 2011 Present. Pediatric GI Journal Club. Multiple presentations per year. July 2008 Present. Pediatric Resident Noon Conference. General Pediatric Gastroenterology Topics. July 2008 Present. Liver Research Center. Have presented research updates and multiple journal club presentations per year. January 2010 Present. 8