Alzheimer s Disease Centers meeting San Diego, CA October 14, NIA-Division of Neurosciences update"
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1 Alzheimer s Disease Centers meeting San Diego, CA October 14, 2017 NIA-Division of Neurosciences update" Eliezer Masliah, M.D. Director, Division of Neuroscience, National Institute on Aging, NIH
2 AD grants funded for FY17 (estimate)
3 NIA-AD accomplishments FY16-17 TRC-PAD ACTC Inflam ApoE Stem cells Synapses Genetics Tau Abeta R01 s AMP-AD MOVE2 Translational MODEL-AD Alz Dis Centers Wake Forest Michigan BU Renewed FY16 and 17 New program
4 New AD Epidemiological studies FY16-17
5 Examples of new epidemiological studies FY17 NIA contact: Dallas Anderson
6 ApoE, Sex and risk for AD
7 AD grants CLINICAL TRIALS FY16-17 (Total= 59) NIA contact: Laurie Ryan and Kristina McLinden Early-stage Clinical Drug Development (Phase I and Phase II Clinical Trials) (23 total) Amyloid (8) Neurotransmitter receptors (2) Metabolism and Bioenergetics (3) Vasculature (2) Growth Factors and Hormones (1) Multi-target (4) Oxidative stress (1) other (2) Late-stage Clinical Drug Development (Phase III Clinical Trials) (5 total) Amyloid (3) Vasculature (2) Non-pharm (23 total) Exercise (5) Combination therapy (5) Cognitive training (5) Diet (2) Other (6) Clinical Therapy Development for the Neuropsychiatric Symptoms of AD (8 total) Pharmacological (5) Non-pharmacological (5)
8 NIH new clinical trials definition and efforts to enhance recruitment A research study in which one or more human subjects are prospectively assigned to one or more interventions for the purpose of modifying one or more healthrelated biomedical or behavioral processes and/or endpoints, to evaluate the effects of those interventions on health-related biomedical or behavioral outcomes. Increase transparency Increase data sharing Increase reporting of results (even if negative) With Alzheimer s Association implemented a working group to establish a National strategy to enhance recruitment for clinical trials F2F meeting April 28, 2017; met at AAIC 2017; National strategy by the fall
9 Global Alzheimer s Platform: TRC-PAD NIA contact: Laurie Ryan Trial-Ready Cohort for Preclinical/Prodromal Alzheimer s Disease Academic PIs: Paul Aisen, Reisa Sperling, Jeff Cummings The GAP Foundation: George Vradenburg, John Dwyer, Debra Lappin, Richard Mohs, Luc Truyen, Jason Bork et al Accelerate drug development for AD and establish an infrastructure to ensure timely recruitment TRC-PAD will establish a trial-ready, biomarker-positive cohort (initial n=2000) at ~60 sites across North America, to facilitate recruitment into preclinical and prodromal AD trials.
10 Continued and NEW Funding Opportunities for FY18 Commonalities and Interactions Between Neurodegenerative Diseases (J. Hsiao) Understanding the Impact of Sex Differences (S. Petanceska) Biogenesis of Exosomes in Alzheimer s Disease (A. Yang) Mechanisms of Selective Neuronal Vulnerability in Alzheimer s Disease (B. Wise) Human Cell biology of genetic variants in Alzheimer s Disease (B. Wise) Complex biology of resilience in Alzheimer s Disease (S. Petanceska) Pragmatic Trials for Dementia Care in Long Term Services (P. Bhattachayya/N.Silverberg) Leveraging Existing Cohort Studies to Clarify Risk and Protective Factors (D. Anderson) Understanding the Effects of APOE2 (S. Petanceska) Health disparities in Alzheimer s Disease (C. Elliot) Relationship between Delirium and Alzheimer s Disease (L. Roberts) Network to establish definition for cognitive resilience (M. Wagster) Sensory/motor system impact on Alzheimer s Disease (C. St Hillaire-Clarke) Misfolded protein polymorphism in Alzheimer s Disease (A. Yang) Sleep and circadian disorders in Alzheimer s Disease (M. Mackiewicz) NOI to publish FOA for AD Centers (P30) (N. Silverberg)
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12 Program integration toward achieving the 2025 goal of NAPA (from discovery to the clinic) AMP-AD MOVE2 BPN R01 s Alz Dis Centers MODEL-AD Centers Alz Dis Centers Alz Dis Centers ACTC TRC-PAD UDALL CENTERS
13 Robert D. Terry ( ) Hartford Connecticut, January 13, 1924 San Diego, May 20, 2017 WWII Veteran, 82 nd airborne Battle of Bulge,1943 Trained many generations of neuropathologists Founder of modern neuropathology of neurodegenerative disorders Chair of Pathology, 1969 Fine structure of tangles and plaques, 1960 First NIA grant for AD research, 1961 Founder of first AD Research Center, UCSD 1985 First winner Potamkin prize, 1988 Met Life Foundation Award, 1990
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