Parkinson s research in UCC: Lifestyle factors and improving therapies
|
|
- Meagan Shepherd
- 5 years ago
- Views:
Transcription
1 Parkinson s research in UCC: Lifestyle factors and improving therapies Professor Aideen Sullivan University College Cork
2 What happens in the brain in Parkinson s? MIDBRAIN STRIATUM Movement Healthy brain Parkinson s brain Motor symptoms RIGIDITY RESTING TREMOR POSTURAL INSTABILITY BRADYKINESIA
3 What happens in the brain in Parkinson s? What are we trying to prevent /slow down? 1. Gradual loss of dopamine neurons that control movement 2. A protein called alpha-synuclein builds up (aggregates) and spreads through the nervous system 3. As the disease progresses, many areas of the nervous system are affected and this causes a multitude of different symptoms Lewy body
4 But it s not just dopamine neurons that are affected Gastrointestinal issues Mood disorders Loss of smell Sleep disturbances Swallowing & speech problems Bladder issues Cognitive impairment Non-motor symptoms have a huge impact on patients
5 Why does Parkinson s happen? For most patients, the cause of Parkinson s is unknown Risk factors: Age Genetics Environment (Pesticides) Genetic causes e.g. alpha-synuclein, LRKK2, parkin, PINK1, DJ-1
6 Researching to improve therapies and earlier diagnostics for Parkinson s A Centre of Excellence in Neurodegeneration OUR GOAL Apply our knowledge to develop better therapies, and improve quality of life for people living with major brain diseases 40 Research teams
7 Researching to improve therapies for Parkinson s: How are we doing this? People body / tissue / cell / molecular changes lifestyle / environment Models laboratory models for testing disease mechanisms People Therapies Diagnostics new therapies for clinical trials life-style interventions new diagnostic approaches Ultimate aim: to understand causes of Parkinson s and translate findings to better therapies that prevent or slow down the disease
8 Researching to improve therapies for Parkinson s: How are we doing this? Metabolism Longevity Nurturing factors Neurotransmission Cell survival Gut-brain axis Microbiome Protein Metabolic health Cell /longevity waste disposal control Insulin/IGF1 Lifestyle factors Environment Inflammation Vascular
9 Researching to improve therapies for Parkinson s: Why are we doing this? MIDBRAIN Parkinson s brain STRIATUM Movement Add dopamine or mimic its actions Effective in the short-term Do not stop disease progression Disabling side-effects with longterm use
10 Researching to improve therapies for Parkinson s: How are we doing this? 1. Neurotrophic factors natural proteins that nurture dopamine neurons in the developing brain
11 Researching to improve therapies for Parkinson s Non-motor symptoms greatly affect patients quality of life 2. Focus on non-motor symptoms - new laboratory models (cognitive symptoms, gastrointestinal symptoms) - study on sleep, diet and mood (collaboration with Cork Parkinson s Support Group)
12 Preventing Parkinson s by understanding lifestyle factors for healthy ageing
13 Parkinson s will be best prevented both by understanding lifestyle factors that may slow down its progress and by developing new therapies that target the cell and molecular systems that cause the disease
14 Management Team Cora O Neill Aideen Sullivan Suzanne Timmons Yvonne Nolan Gerard O Keeffe Aisling Ryan John Cryan Team Barry Boland Geraldine Boylan Jason Chan Danny Costello Tom Cotter Simon Cronin Ruslan Dmitriev Ted Dinan Tony Foley Collette Hand Niall Hyland John McCarthy Justin McCarthy Will Molloy Deirdre Murray Nicole Muller Ken O Halloran Olivia O Leary Dervla O Malley Denis O Mahony Siobhain O Mahony Sean O Sullivan Colm O Tuathaigh Orna O Toole Dmitri Papkovsky Mark Rae Annalisa Setti George Shorten Brian Sweeney Andre Toulouse Christian Waeber Paul Young Affiliated PIs Stephen Byrne Kellie Dean Susan Joyce Eric Moore Tom Moore Mary McCaffrey Caitriona O Driscoll Rosemary O Connor
15 Cork neuroscience centre Funding and support The Netherlands Brain Bank Translational Research Access Programme (TRAP) UCC
16 So hope for a great sea-change On the far side of revenge. Believe that further shore Is reachable from here. Believe in miracle And cures and healing wells
USING PRECISION MEDICINE TO HELP PATIENTS WITH PARKINSON S DISEASE. The Michael J. Fox Foundation for Parkinson s Research
USING PRECISION MEDICINE TO HELP PATIENTS WITH PARKINSON S DISEASE The Michael J. Fox Foundation for Parkinson s Research MJFF IS THE WORLD S LARGEST NONPROFIT FUNDER OF PD RESEARCH Our Mission We are
More informationTreatment of Parkinson s Disease: Present and Future
Treatment of Parkinson s Disease: Present and Future Karen Blindauer, MD Professor of Neurology Director of Movement Disorders Program Medical College of Wisconsin Neuropathology: Loss of Dopamine- Producing
More informationJohn. F. Cryan. Brain Research in Ireland (An Overview of Successes, Opportuni;es and Challenges)
http://apc.ucc.ie Brain Research in Ireland (An Overview of Successes, Opportuni;es and Challenges) John. F. Cryan Professor & Chair Department of Anatomy & Neuroscience & Principal Inves:gator, Alimentary
More informationParkinson s disease: Can we move in the right direction?
Snapshots of Doctoral Research at University College Cork 2012 Parkinson s disease: Can we move in the right direction? Shane Hegarty Department of Anatomy and Neuroscience, UCC Imagine losing the control
More informationUniversity of Applied Sciences. February 9, 2017, Fribourg, Switzerland
Gut Microbiota: A Key Regulator of Brain and Metabolic Function Dr. Cristina Torres Fuentes & Prof. John F. Cryan APC Microbiome Institute, University College Cork, Cork, Ireland University of Applied
More informationIII./3.1. Movement disorders with akinetic rigid symptoms
III./3.1. Movement disorders with akinetic rigid symptoms III./3.1.1. Parkinson s disease Parkinson s disease (PD) is the second most common neurodegenerative disorder worldwide after Alzheimer s disease.
More informationThe PD You Don t See: Cognitive and Non-motor Symptoms
The PD You Don t See: Cognitive and Non-motor Symptoms Benzi M. Kluger, M.D., M.S. Assistant Professor of Neurology and Psychiatry University of Colorado Denver Goals 1) What are the most common non-motor
More informationA Gut Feeling About the Brain: The Microbiota-Gut-Brain Axis
A Gut Feeling About the Brain: The Microbiota-Gut-Brain Axis Prof. John. F. Cryan MRIA Dept. Anatomy & Neuroscience and APC Microbiome Institute University College Cork Ireland @jfcryan The Language of
More informationScott J Sherman MD, PhD The University of Arizona PARKINSON DISEASE
Scott J Sherman MD, PhD The University of Arizona PARKINSON DISEASE LEARNING OBJECTIVES The Course Participant will: 1. Be familiar with the pathogenesis of Parkinson s Disease (PD) 2. Understand clinical
More informationThe PD You Don t See: Cognitive and Non-motor Symptoms
The PD You Don t See: Cognitive and Non-motor Symptoms Benzi M. Kluger, M.D., M.S. Associate Professor of Neurology and Psychiatry Director Movement Disorders Center University of Colorado Denver Goals
More informationDISORDERS OF THE MOTOR SYSTEM. Jeanette J. Norden, Ph.D. Professor Emerita Vanderbilt University School of Medicine
DISORDERS OF THE MOTOR SYSTEM Jeanette J. Norden, Ph.D. Professor Emerita Vanderbilt University School of Medicine THE MOTOR SYSTEM To understand disorders of the motor system, we need to review how a
More informationParkinson s UK Brain Bank
Parkinson s UK Brain Bank From Brain to Breakthrough Dr George Gveric Manager 19 October 2018 Coordinated approach Donors Relatives Information Reporting Researchers Tissue supply Quality assurance Expertise
More informationMaking Every Little Bit Count: Parkinson s Disease. SHP Neurobiology of Development and Disease
Making Every Little Bit Count: Parkinson s Disease SHP Neurobiology of Development and Disease Parkinson s Disease Initially described symptomatically by Dr. James Parkinson in 1817 in An Essay on the
More informationCase Study 2: Neurological Degenerative Disease FDA Regulatory and Clinical Background
Case Study 2: Neurological Degenerative Disease FDA Regulatory and Clinical Background Heather Benz, Ph.D. FDA Center for Devices and Radiological Health Neurological Degenerative Diseases Neurodegenerative
More informationMercy University Hospital Cork city community
Mercy University Hospital Cork city community A 3-year innovative project funded by Genio/HSE An integrated service for patients and their families Providing excellent acute hospital care where necessary,
More informationWelcome and Introductions
Parkinson s Disease Spotlight on Treatment Advances Tuesday, January 26, 2016 Welcome and Introductions Stephanie Paul Vice President Development and Marketing American Parkinson Disease Association 1
More informationPARKINSON S DISEASE. Nigrostriatal Dopaminergic Neurons 5/11/16 CARDINAL FEATURES OF PARKINSON S DISEASE. Parkinson s disease
5/11/16 PARKINSON S DISEASE Parkinson s disease Prevalence increases with age (starts 40s60s) Seen in all ethnic groups, M:F about 1.5:1 Second most common neurodegenerative disease Genetics role greater
More informationPrecise evaluation of motor and non-motor dysfunction in Parkinson s disease using the KINARM
Precise evaluation of motor and non-motor dysfunction in Parkinson s disease using the KINARM Project lead: Dr. Ron Levy Pauline Gaprielian, Dr. Stephen H. Scott, Dr. Giovanna Pari Queen s University,
More informationThe symptoms of the Parkinson s disease may vary from person to person. The symptoms might include the following:
1 PARKINSON S DISEASE Parkinson's disease is a long term disease related to the central nervous system that mainly affects the motor system, resulting in the loss of dopamine, which helps in producing
More informationWelcome and Introductions
Parkinson s Disease Spotlight on Addressing Motor and Non-Motor Symptoms The Changing Landscape Wednesday, March 8, 2017 Welcome and Introductions Stephanie Paul Vice President Development and Marketing
More informationNeurodegenerative Disease. April 12, Cunningham. Department of Neurosciences
Neurodegenerative Disease April 12, 2017 Cunningham Department of Neurosciences NEURODEGENERATIVE DISEASE Any of a group of hereditary and sporadic conditions characterized by progressive dysfunction,
More informationPresented by Meagan Koepnick, Josh McDonald, Abby Narayan, Jared Szabo Mentored by Dr. Doorn
Presented by Meagan Koepnick, Josh McDonald, Abby Narayan, Jared Szabo Mentored by Dr. Doorn Objectives What agents do we currently have available and what do we ideally need? What biomarkers exist for
More informationIssues for Patient Discussion
onmotor complications radykinesia Screening Tools asked PD micrographia eurodegeneration Designed for Use by Family Practitioners remor on-off opamine agonists tiffness depression ostural instability wearing
More informationMETHOD FOR PREDICTING THE EARLY ONSET AND SEVERITY OF LEVODOPA INDUCED DYSKINESIA (LID) IN SUBJECTS DIAGNOSED OF PARKINSON S DISEASE
METHOD FOR PREDICTING THE EARLY ONSET AND SEVERITY OF LEVODOPA INDUCED DYSKINESIA (LID) IN SUBJECTS DIAGNOSED OF PARKINSON S DISEASE Madrid, 14 de noviembre de 2017 1. THE TEAM AND THE INSTITUTIONS BEHIND
More informationNervous System. Unit 6.6 (6 th Edition) Chapter 7.6 (7 th Edition)
Nervous System Unit 6.6 (6 th Edition) Chapter 7.6 (7 th Edition) 1 Learning Objectives Identify the main parts (anatomy) of a neuron. Identify the 2 divisions of nervous system. Classify the major types
More informationPARKINSON S DISEASE 馬 萬 里. Chinese character for longevity (shou) Giovanni Maciocia
PARKINSON S DISEASE Chinese character for longevity (shou) Giovanni Maciocia 馬 萬 里 PARKINSON'S DISEASE Parkinson's disease is a clinical syndrome characterized by impairment of movement, rigidity and tremor,
More informationUsing Sources in the GDP
Using Sources in the GDP The following are five examples of sources that you may encounter while working on your GDP project. The information contained in each of these sources (shown by screen shot) was
More informationOptimizing Clinical Communication in Parkinson s Disease:
Optimizing Clinical Communication in Parkinson s Disease:,Strategies for improving communication between you and your neurologist PFNCA Symposium March 25, 2017 Pritha Ghosh, MD Assistant Professor of
More informationWHO, WHAT, WHEN AND WHERE OF PARKINSON S DIAGNOSIS. MJFF Third Thursdays Webinar March 17, 2016
WHO, WHAT, WHEN AND WHERE OF PARKINSON S DIAGNOSIS MJFF Third Thursdays Webinar March 17, 2016 WHAT WE LL COVER TODAY How is Parkinson s misdiagnosed? How is Parkinson s diagnosed today? Can we use DaTscan
More informationWHAT DEFINES YOPD? HANDLING UNIQUE CONCERNS REBECCA GILBERT, MD, PHD VICE PRESIDENT, CHIEF SCIENTIFIC OFFICER, APDA MARCH 14, 2019
WHAT DEFINES YOPD? HANDLING UNIQUE CONCERNS REBECCA GILBERT, MD, PHD VICE PRESIDENT, CHIEF SCIENTIFIC OFFICER, APDA MARCH 14, 2019 YOUNG ONSET PARKINSON S DISEASE Definition: Parkinson s disease diagnosed
More informationSNOEZELEN FOR THE PEOPLE WITH PARKINSON'S DISEASE
SNOEZELEN FOR THE PEOPLE WITH PARKINSON'S DISEASE Maja Povše, University Rehabilitation Institute, Republic of Slovenia Soča ISNA-MSE'S XIII International Congress, Crete, 27.10.2016 S L O V E N I A Slovenia
More informationModeling Parkinson s disease: systems to test gene-environment interactions
Modeling Parkinson s disease: systems to test gene-environment interactions Jason Cannon, Ph.D. Pittsburgh Institute of Neurodegenerative Diseases University of Pittsburgh Outline Parkinson s disease (PD)
More informationEvaluation of Parkinson s Patients and Primary Care Providers
Evaluation of Parkinson s Patients and Primary Care Providers 2018 Movement Disorders Half Day Symposium Elise Anderson MD Medical Co-Director, PBSI Movement Disorders 6/28/2018 1 Disclosures GE Speaker,
More informationThe Parkinson s You Can t See
The Parkinson s You Can t See We principally see the motor phenomena of Parkinson's disease, but is there an early stage without visible features? Might this provide a window for disease-modifying therapy?
More informationMETHOD FOR PREDICTING THE EARLY ONSET AND SEVERITY OF LEVODOPA INDUCED DYSKINESIA (LID) IN SUBJECTS DIAGNOSED OF PARKINSON S DISEASE
METHOD FOR PREDICTING THE EARLY ONSET AND SEVERITY OF LEVODOPA INDUCED DYSKINESIA (LID) IN SUBJECTS DIAGNOSED OF PARKINSON S DISEASE Con el respaldo de ACCIÓ Madrid, 14 de noviembre de 2017 1. THE TEAM
More informationParkinson s Disease. Prevalence. Mark S. Baron, M.D. Cardinal Features. Clinical Characteristics. Not Just a Movement Disorder
Prevalence Parkinson s Disease Mark S. Baron, M.D. Associate Professor of Neurology Movement Disorders Section VCU School of Medicine Common disorder Approaching 1% by 65 yrs of age, 2% by 80 yrs of age
More informationSECTION 1: as each other, or as me. THE BRAIN AND DEMENTIA. C. Boden *
I read all the available books by other [people with] Alzheimer s disease but they never had quite the same problems as each other, or as me. I t s not like other diseases, where there is a standard set
More informationWhat if it s not Alzheimer s? Update on Lewy body dementia and frontotemporal dementia
What if it s not Alzheimer s? Update on Lewy body dementia and frontotemporal dementia Dementia: broad term for any acquired brain condition impairing mental function such that ADLs are impaired. Includes:
More informationDevelopment of the National Integrated Care Pathway for Older Persons
Development of the National Integrated Care Pathway for Older Persons 2 nd November, 2017 Cork University Hospital Dr Patrick Barry, MB,MD, FRCPI Acting Lead for Integrated Care, CUH 1 Context :Integrated
More informationChapter 20. Media Directory. Amyotrophic Lateral Sclerosis. Alzheimer s Disease. Huntington s Chorea. Multiple Sclerosis
Chapter 20 Drugs for Degenerative Diseases of the Nervous System Slide 18 Media Directory Levadopa Animation Upper Saddle River, New Jersey 07458 All rights reserved. Alzheimer s Disease Amyotrophic Lateral
More informationUNDERSTANDING PARKINSON S DISEASE
UNDERSTANDING PARKINSON S DISEASE WHAT IS PARKINSON S DISEASE? A progressive disease of the nervous system marked by tremor, muscular rigidity, and slow, imprecise movement, chiefly affecting middleaged
More informationHow to Effectively Manage the Motor Symptoms of HD
How to Effectively Manage the Motor Symptoms of HD Yvette Bordelon, MD, PhD Associate Clinical Professor of Neurology David Geffen School of Medicine at UCLA The information provided by speakers in workshops,
More informationWELCOME. Parkinson s 101 for the Newly Diagnosed. Today s Topic: Parkinson s Basics presented by Cari Friedman, LCSW
WELCOME Parkinson s 101 for the Newly Diagnosed Today s Topic: Parkinson s Basics presented by Cari Friedman, LCSW Parkinson s Disease 101 Presenter for Today Cari Friedman, LCSW Patient and Family Service
More informationMovement Disorders: A Brief Overview
Movement Disorders: A Brief Overview Albert Hung, MD, PhD Massachusetts General Hospital Harvard Medical School August 17, 2006 Cardinal Features of Parkinsonism Tremor Rigidity Bradykinesia Postural imbalance
More informationInvestigating molecular mechanisms of progression of Parkinson s Disease in human brain
Investigating molecular mechanisms of progression of Parkinson s Disease in human brain Murray ; C.E., Pressey ; S.N., Heywood 2 ; W.E., Hargreaves 3 ; I.P., Neergheen 3 ; V., Wauters ; S., Palkovits 4
More informationRAMBAM. Revolutionary New Treatment for Parkinson s Disease Tremors. Health Care Campus. Information Guide & Treatment Options
RAMBAM Health Care Campus Revolutionary New Treatment for Parkinson s Disease Tremors Information Guide & Treatment Options Table of Contents Introduction 1 Parkinson s Disease Symptoms: Tremors 2 Current
More informationNovel Targets of disease modifying therapy for Parkinson disease. David G. Standaert, MD, PhD John N. Whitaker Professor and Chair of Neurology
Novel Targets of disease modifying therapy for Parkinson disease David G. Standaert, MD, PhD John N. Whitaker Professor and Chair of Neurology Disclosures Dr. Standaert has served as a paid consultant
More informationDate of Referral: Enhanced Primary Care Pathway: Parkinson s Disease
Specialist LINK Linking Physicians CALGARY AND AREA Patient Name: Date of Birth: Calgary RHRN: PHN / ULI: Date of Referral: Referring MD: Fax: Today s Date: CONFIRMATION: TRIAGE CATEGORY: REFERRAL STATUS:
More informationTILDA Policy Conference
TILDA Policy Conference Graham Love Chief Executive Health Research Board Mansion House, Nov 10 2014 Health Policy, 1-2 pm The HRB, Ageing & TILDA Dr Graham Love, Chief Executive, Health Research Board
More informationHeadway Victoria Epilepsy and Parkinson s Centre
Headway Victoria Epilepsy and Parkinson s Centre Parkinson s Overview and Medication Shannon Oatway Community Education/ Awareness Coordinator What is Parkinson s Disease? The basics It is a chronic and
More informationDesigning patient-centered clinical trials: Results of the MDIC project to use patient preference information to design clinical trials
1 Informative series of workshops featuring emerging trends in medical technology regulatory science, MDIC projects and subject matter experts sharing perspectives, progress and opportunities. Designing
More informationTUESDAY, MARCH 28, 2017 WEDNESDAY, MARCH 29, 2017 WELCOME RECEPTION (VIENNA CITY HALL)
KEY: PRE CONFERENCE SYMPOSIUM SPONSORED SYMPOSIUM SYMPOSIUM PLENARY LECTURE FORUM OTHER EVENT *PRE-REGISTRATION IS REQUIRED FOR THE INFORMAL NETWORKING WITH PROFESSOR LUNCH SESSION TUESDAY, MARCH 28, 2017
More informationIrish National Eating Disorder Conference February 23 th 2018: Development of an evidence and values based eating disorder service: the HSE approach
Irish National Eating Disorder Conference February 23 th 2018: Development of an evidence and values based eating disorder service: the HSE approach (...a new hope) Dr Sara McDevitt, National Clinical
More informationEnhanced Primary Care Pathway: Parkinson s Disease
Enhanced Primary Care Pathway: Parkinson s Disease 1. Focused summary of PD relevant to primary care Parkinson s Disease (PD) and Essential tremor (ET) are two of the most common movement disorders encountered
More information10th Medicine Review Course st July Prakash Kumar
10th Medicine Review Course 2018 21 st July 2018 Drug Therapy for Parkinson's disease Prakash Kumar National Neuroscience Institute Singapore General Hospital Sengkang General Hospital Singhealth Duke-NUS
More informationPathogenesis of Degenerative Diseases and Dementias. D r. Ali Eltayb ( U. of Omdurman. I ). M. Path (U. of Alexandria)
Pathogenesis of Degenerative Diseases and Dementias D r. Ali Eltayb ( U. of Omdurman. I ). M. Path (U. of Alexandria) Dementias Defined: as the development of memory impairment and other cognitive deficits
More informationThe Role of DOPAL in Parkinson s Disease. Karenee Demery. Copyright May, 2015, Karenee Demery and Koni Stone
The Role of DOPAL in Parkinson s Disease Karenee Demery Copyright May, 2015, Karenee Demery and Koni Stone Parkinson s disease is an incurable, neurodegenerative disease. The cause is still not fully understood.
More informationParkinson s Foundation
Parkinson s Foundation PD ExpertBriefing: Diagnosis PD, Now What? Managing the First Few Years with Parkinson s Led By: Suketu Khandhar, M.D., Medical Director at Kaiser Permanente Northern California
More informationLet s Look at Parkinson s (PD) Sheena Morgan Parkinson s Disease Nurse Specialist Isle of Wight NHS Trust November 2016
Let s Look at Parkinson s (PD) Sheena Morgan Parkinson s Disease Nurse Specialist Isle of Wight NHS Trust November 2016 What is Parkinson s? Parkinson's is a progressive neurological condition. People
More informationParkinson s Disease. Sirilak yimcharoen
Parkinson s Disease Sirilak yimcharoen EPIDEMIOLOGY ~1% of people over 55 years Age range 35 85 years peak age of onset is in the early 60s ~5% of cases characterized by an earlier age of onset (typically
More informationWhat is Parkinson s disease?
What is Parkinson s disease? 2 credit hour course Parkinson s disease (PD) is a disorder caused by a loss of nerve cells in a small part of the brain called the substantia nigra. This area of nerve cells
More informationEvaluation and Management of Parkinson s Disease in the Older Patient
Evaluation and Management of Parkinson s Disease in the Older Patient David A. Hinkle, MD, PhD Comprehensive Movement Disorders Clinic Pittsburgh Institute for Neurodegenerative Diseases University of
More informationsymptoms of Parkinson s disease EXCEPT.
M. Angele Theard, M.D Asst. Professor, Washington University, St. Louis, MO Quiz team; Shobana Rajan, M.D; Suneeta Gollapudy, MD; Verghese Cherian, M.D, M. Angele Theard, MD This quiz is being published
More informationPa t h w a y s. Pa r k i n s o n s. MacMahon D.G. Thomas S. Fletcher P. Lee M. 2006
Pathways bolt 16/6/06 20:38 Page 1 Pa t h w a y s A PARADIGM FOR DISEASE MANAGEMENT IN Pa r k i n s o n s Disease MacMahon D.G. Thomas S. Fletcher P. Lee M. 2006 Clinical diagnosis Pa r k i n s o n s disease
More informationPilates as a modality to increase movement and improve quality of life for those suffering from Parkinson s Disease
Pilates as a modality to increase movement and improve quality of life for those suffering from Parkinson s Disease Miranda Handke 23 July 2016 Comprehensive Global Format Brisbane, Australia 2015 Abstract
More informationUnderstanding Parkinson s Disease Important information for you and your loved ones
Patient Education Understanding Parkinson s Disease Important information for you and your loved ones This handout explains the signs, symptoms, and possible treatments of Parkinson s disease. Parkinson
More information05-Nov-15. Impact of Parkinson s Disease in Australia. The Nature of Parkinson s disease 21st Century
Peter Silburn Professor Clinical Neuroscience University of Queensland Queensland Brain Institute Neurosciences Queensland Impact of in Australia Second most common neurodegenerative disorder Up to 64,000
More informationgroundbreaking partnership to help many thousands of Australians, and their families, whose lives are scarred by bipolar disorder
Dear Supporter, As the leaders of the Black Dog Institute and NeuRA (Neuroscience Research Australia) we are excited that high quality research is helping us better understand causes and treatments of
More informationTHIS IS NOT YOUR GRANDMOTHER S DISEASE: WHAT DOES BEING DIAGNOSED WITH PARKINSON S DISEASE MEAN TODAY?
THIS IS NOT YOUR GRANDMOTHER S DISEASE: WHAT DOES BEING DIAGNOSED WITH PARKINSON S DISEASE MEAN TODAY? THURSDAY MARCH 14, 2019 REBECCA GILBERT, MD, PHD VICE PRESIDENT, CHIEF SCIENTIFIC OFFICER, APDA AMERICAN
More informationCentral nervous system
Central nervous system By Dr. Mohsen Dashti Clinical Medicine & Pathology 316 7 th Lecture Lecture outline Review of structure & function. Symptoms, signs & tests. Specific diseases. Review of structure
More informationPD ExpertBriefing: What s in the Parkinson s Pipeline
PD ExpertBriefing: What s in the Parkinson s Pipeline Presented by: David G. Standaert, M.D., Ph.D. Professor of Neurology Director, Center for Neurodegeneration and Experimental Therapeutics University
More informationDEMENTIA and BPSD in PARKINSON'S DISEASE. DR. T. JOHNSON. NOVEMBER 2017.
DEMENTIA and BPSD in PARKINSON'S DISEASE. DR. T. JOHNSON. NOVEMBER 2017. Introduction. Parkinson's disease (PD) has been considered largely as a motor disorder. It has been increasingly recognized that
More informationCAREGIVER SUMMIT. The PD You Can't See: Dealing with Non-Motor Symptoms. Kaitlyn Roland, PhD. Sponsored by:
CAREGIVER SUMMIT The PD You Can't See: Dealing with Non-Motor Symptoms Kaitlyn Roland, PhD Sponsored by: Cognition VS Dementia Memory Executive Function Attention Bradyphrenia Visuospatial Language Hallucinations
More informationUPDATE ON RESEARCH IN PARKINSON S DISEASE
UPDATE ON RESEARCH IN PARKINSON S DISEASE Charles H. Adler, M.D., Ph.D. Professor of Neurology Mayo Clinic College of Medicine Co-Principal Investigator Arizona Parkinson s Disease Consortium Arizona Study
More informationUpdate on Parkinson s disease and other Movement Disorders October 2018
Update on Parkinson s disease and other Movement Disorders October 2018 DR. JONATHAN EVANS CONSULTANT IN NEUROLOGY QUEEN S MEDICAL CENTRE NOTTINGHAM Disclosures: Honoraria UCB, Britannia, Allergan, AbbVie
More informationEuropean Commission approves ONGENTYS (opicapone) a novel treatment for Parkinson s disease patients with motor fluctuations
July 6, 2016 European Commission approves ONGENTYS (opicapone) a novel treatment for Parkinson s disease patients with motor fluctuations Porto, 5 July 2016 BIAL announced that the medicinal product ONGENTYS
More informationPrion-like propagation of alpha-synuclein aggregates in the brain of wild-type mice
Prion-like propagation of alpha-synuclein aggregates in the brain of wild-type mice Nolwen L. Rey, PhD Patrik Brundin s Laboratory, Van Andel Research Institute Grand Rapids, Michigan, USA 15th Annual
More informationPARKINSON S PRIMER. Dr. Kathryn Giles MD, MSc, FRCPC Cambridge, Ontario, Canada
PARKINSON S PRIMER Dr. Kathryn Giles MD, MSc, FRCPC Cambridge, Ontario, Canada COPYRIGHT 2017 BY SEA COURSES INC. All rights reserved. No part of this document may be reproduced, copied, stored, or transmitted
More informationDrug Therapy of Parkinsonism. Assistant Prof. Dr. Najlaa Saadi PhD Pharmacology Faculty of Pharmacy University of Philadelphia
Drug Therapy of Parkinsonism Assistant Prof. Dr. Najlaa Saadi PhD Pharmacology Faculty of Pharmacy University of Philadelphia Parkinsonism is a progressive neurological disorder of muscle movement, usually
More informationDerived copy of Nervous System Disorders *
OpenStax-CNX module: m57764 1 Derived copy of Nervous System Disorders * Shannon McDermott Based on Nervous System Disorders by OpenStax This work is produced by OpenStax-CNX and licensed under the Creative
More informationParkinson Disease. Lorraine Kalia, MD, PhD, FRCPC. Presented by: Ontario s Geriatric Steering Committee
Parkinson Disease Lorraine Kalia, MD, PhD, FRCPC Key Learnings Parkinson Disease (L. Kalia) Key Learnings Parkinson disease is the most common but not the only cause of parkinsonism Parkinson disease is
More informationThe Nobel Prize in Physiology or Medicine 2000
The Nobel Prize in Physiology or Medicine 2000 Press Release NOBELFÖRSAMLINGEN KAROLINSKA INSTITUTET THE NOBEL ASSEMBLY AT THE KAROLINSKA INSTITUTE 9 October 2000 The Nobel Assembly at Karolinska Institutet
More informationMoving fast or moving slow: an overview of Movement Disorders
Moving fast or moving slow: an overview of Movement Disorders Mini Medical School October 25, 2018 Heather Rigby, MD, FRCPC 2014 MFMER slide-1 2014 MFMER slide-2 Basal Ganglia Dysfunction - Movement Disorders
More informationBasal ganglia motor circuit
Parkinson s Disease Basal ganglia motor circuit 1 Direct pathway (gas pedal) 2 Indirect pathway (brake) To release or augment the tonic inhibition of GPi on thalamus Direct pathway There is a tonic inhibition
More informationStrategies for Dementia and Alzheimer s Care. Welcome and Introduction. Thank you, Why this topic? 3/9/2017
Strategies for Dementia and Alzheimer s Care LEADERS 2017 SLIDES PREPARED FOR PREVIEW MARCH CAMILLE PAVY CLAIBOURNE, APRN, PHD. Welcome and Introduction STRATEGIES CARING AND COMMUNICATING IN CAREGIVING
More informationFOUNDATION OF UNDERSTANDING PARKINSON S DISEASE
FOUNDATION OF UNDERSTANDING PARKINSON S DISEASE DEE SILVER M.D MOVEMENT DISORDER SPECIALIST MEDICAL DIRECTOR -- PARKINSON ASSOCIATION OF SAN DIEGO 1980 TO PRESENT SCRIPPS MEMORIAL HOSPITAL, LA JOLLA CA.
More informationMind Altering Microbes: Role of Microbiota-Gut-Brain Axis in Stress-Related Disorders
Mind Altering Microbes: Role of Microbiota-Gut-Brain Axis in Stress-Related Disorders John F. Cryan Ph.D. Professor & Chair Department of Anatomy & Neuroscience & Principal Investigator, Alimentary Pharmabiotic
More informationClinimetrics, clinical profile and prognosis in early Parkinson s disease Post, B.
UvA-DARE (Digital Academic Repository) Clinimetrics, clinical profile and prognosis in early Parkinson s disease Post, B. Link to publication Citation for published version (APA): Post, B. (2009). Clinimetrics,
More informationANIMAL MODELS OF PARKINSON S DISEASE: STATE OF THE FIELD & THE FUTURE! KULDIP DAVE
ANIMAL MODELS OF PARKINSON S DISEASE: STATE OF THE FIELD & THE FUTURE! KULDIP DAVE 21 February 217 MJFF IS THE WORLD S LARGEST NONPROFIT FUNDER OF PD RESEARCH Our Mission To accelerate the development
More informationPrior Authorization with Quantity Limit Program Summary
Gocovri (amantadine) Prior Authorization with Quantity Limit Program Summary This prior authorization applies to Commercial, NetResults A series, SourceRx and Health Insurance Marketplace formularies.
More informationParkinson s disease Therapeutic strategies. Surat Tanprawate, MD Division of Neurology University of Chiang Mai
Parkinson s disease Therapeutic strategies Surat Tanprawate, MD Division of Neurology University of Chiang Mai 1 Scope Modality of treatment Pathophysiology of PD and dopamine metabolism Drugs Are there
More informationProgram Highlights. Michael Pourfar, MD Co-Director, Center for Neuromodulation New York University Langone Medical Center New York, New York
Program Highlights David Swope, MD Associate Professor of Neurology Mount Sinai Health System New York, New York Michael Pourfar, MD Co-Director, Center for Neuromodulation New York University Langone
More informationPD AND FALLS J U MALLYA FALLS AWARENESS MEETING
PD AND FALLS J U MALLYA FALLS AWARENESS MEETING 23-09-2016 PD Chronic Progressive neurodegenerative disease Motor system disorder Degeneration of Dopaminergic neurons in Substantia nigra in the midbrain.
More informationLearnings from Parkinson s disease: Critical role of Biomarkers in successful drug development
Learnings from Parkinson s disease: Critical role of Biomarkers in successful drug development Ken Marek Coalition Against Major Diseases and FDA 2014 Annual Scientific Workshop Oct 2014 Disclosure Co-founder
More informationNervous System. Unit 6.6 (6 th Edition) Chapter 7.6 (7 th Edition)
Nervous System Unit 6.6 (6 th Edition) Chapter 7.6 (7 th Edition) 1 Learning Objectives Identify the main parts (anatomy) of a neuron. Identify the 2 divisions of nervous system. Classify the major types
More informationParkinson s Disease. Gillian Sare
Parkinson s Disease Gillian Sare Outline Reminder about PD Parkinson s disease in the inpatient Surgical patients with PD Patients who cannot swallow End of life care Parkinson s disease PD is the second
More informationCDNF: Finnish academia-industry collaboration for unique clinical study in Parkinson s disease
CDNF: Finnish academia-industry collaboration for unique clinical study in Parkinson s disease Brain Diseases Symposium, Helsinki 14 Oct 2016 Pekka Simula, CEO, Herantis Pharma Plc 1 Disclaimer This presentation
More informationROLE AND IMPORTANCE OF REHABILITATION TREATMENT IN PATIENTS WITH PARKINSON S DISEASE VODA, Ioana¹; DOGARU, Gabriela¹, ²
ROLE AND IMPORTANCE OF REHABILITATION TREATMENT IN PATIENTS WITH PARKINSON S DISEASE VODA, Ioana¹; DOGARU, Gabriela¹, ² ¹ University of Medicine and Pharmacy Cluj-Napoca ² Clinical Rehabilitation Hospital
More informationChapter 8. Parkinsonism. M.G.Rajanandh, Dept. of Pharmacy Practice, SRM College of Pharmacy, SRM University.
Chapter 8 Parkinsonism M.G.Rajanandh, Dept. of Pharmacy Practice, SRM College of Pharmacy, SRM University. Definition of Parkinson s Disease Parkinson's disease is a progressive, neurodegenerative disease
More informationPD ExpertBriefing: The Effects of Exercise on PD
PD ExpertBriefing: The Effects of Exercise on PD Led By: Margaret Schenkman, P.T., Ph.D., F.A.P.T.A. Associate Dean for Physical Therapy Education, and Director, Physical Therapy Program, University of
More information