CURRICULUM VITAE SAROSH J. MOTIVALA, Ph.D.

Transcription

1 Sarosh J. Motivala 1 CURRICULUM VITAE SAROSH J. MOTIVALA, Ph.D. PERSONAL HISTORY Business Address Date and Place of Birth Citizenship Marital Status UCLA-Cousins Center for PNI 300 Medical Plaza, Suite 3153 Los Angeles, CA (310) (310) fax smotivala@mednet.ucla.edu April 12, 1969; Mumbai, India U.S.A. Married EDUCATION: UCLA B.A. Psychology University of Miami M.S. Health-Clinical Psychology University of Miami Ph.D. Health-Clinical Psychology UCLA Clinical Internship in Behavioral Medicine LICENSURE: California, PSY PROFESSIONAL EXPERIENCE: PROFESSIONAL ACTIVITES: Committee Service Assistant Professor in Residence UCLA Semel Institute for Neuroscience & Human Behavior 2005-Current Assistant Research Psychologist UCLA Semel Institute for Neuroscience & Human Behavior Post-Doctoral Fellowship in Psychoneuroimmunology UCLA Semel Institute for Neuroscience & Human Behavior Post-Doctoral Fellowship in Psychobiological Sciences UCLA Semel Institute for Neuroscience & Human Behavior American Psychosomatic Society Program Committee for 2008 Annual Conference March 2006-current American Psychological Association Division 38 Health Psychology Research Committee Member. February 2006-current

2 Sarosh J. Motivala 2 Committee Service (continued) Health Psychology Manuscript Initial Review Committee Member. June 2005 January 2007 Dissertation Committee Member, Lauren Ellman, UCLA Psychology Program Dissertation Committee Member, Janet Tomiyama, UCLA Health Psychology Program Dissertation Committee Member, Cheryl Sasso, Pepperdine University Professional Associations & Scholarly Societies Editorial Services Teaching (Supervision & Training) Dissertation Committee Member, Russell Carroll, Pepperdine University Student Representative, Training in Behavioral Medicine Committee, Society for Behavioral Medicine, March 1996-March 1997; March 1998-March American Psychological Association (APA) American Psychosomatic Society (APS) Psychoneuroimmunology Research Society (PNIRS) Ad-Hoc Reviewer for: Brain, Behavior and Immunity Health Psychology Journal of Affective Disorders Biological Psychiatry Annals of Rheumatic Disease Matthew Estrada, Bridge Summer Research Program, 2007 Alice Chen, Research Internship, 2006 Janet Tomiyama, Graduate Student, 2005-Current Jesse Culver, Research Internship, Janani Ramchandran, Research Internship, Kathryn Proudfoot, Psychology Research Internship, Psychology 194B&C, 2003 Kulwant Dosanjh, Student Research Program, 2002 Avishay Sarfatti, Medical Student Research Internship, 2002 Terri Ho, Research Internship, Psychology 194B&C, 2001 Sally Dickerson, Graduate Student,

3 Sarosh J. Motivala 3 HONORS & SPECIAL AWARDS: Pittsburgh Mind/Body Center Summer Institute Travel Award. June 2005 Psychoneuroimmunology Research Society Travel Awards May 2004 and May 2003 Health Emotions Conference Travel Award April, 1998 Robert Maytag Fellow August 1995 August 1998 University of Miami Graduate Student Commendations 1999, 1998, 1996, 1995, 1994 RESEARCH GRANTS AND FELLOWSHIPS RECEIVED: ONGOING SUPPORT * Reflects Direct Costs K23 AG Motivala (PI) 09/30/06-08/31/2011 NIH-NIA $563,750* Aging: Insomnia Treatment and Energy Balance This project builds on a previously funded R01 parent project on behavioral treatment of insomnia in older adults by examining the effects of chronic poor sleep and its treatment on energy balance regulation. R01 AG Irwin (PI) 08/01/05-07/30/10 NIH-NIA Motivala (Co-I noncompensated) $450,000* Aging: Cytokine Mechanisms and Treatment of Insomnia This proposal examines the efficacy of two mind-body interventions, cognitive-behavior therapy and Tai Chi, in improving sleep outcomes in older adults. R01 HL Irwin (PI) 05/01/06-4/30/10 NIH-NHLBI Motivala (Co-I noncompensated) $498,000* Sleep and Immune Mechanisms in Rheumatoid Arthritis This proposal is designed to enhance our understanding of the role played by sleep in symptom severity and disability in rheumatoid arthritis and relationships between sleep and cytokines in mediating these impairments in health. COMPLETED SUPPORT T32 MH Irwin (PI) Role: Post-Doctoral Fellow 07/01/03-06/30/04 NIH-NIMH Postdoctoral Training in Psychoneuroimmunology and Mental Disorders This training grant provides research training for three post-doctoral fellows per year. T32 MH17140 Leuchter (PI) Role: Post-Doctoral Fellow 07/01/01-06/30/03 NIH-NIMH

4 Sarosh J. Motivala 4 Research Training: Psychobiological Sciences. The major goal of this project is to provide fellowship opportunities in the psychobiological sciences. LECTURES AND PRESENTATIONS: Does Tai Chi reduce heightened sympathetic activity in older adults? UCLA Pepper Older Adults Independence Center Presentation Cardiovascular Psychophysiology. UCLA Psychology Cytokines and the Brain: Implications for Neuropsychology. UCLA Seminar in Neuropsychology Psychiatry The relationship between MMPI-2 Depression Scores and Cognitive Functioning in a Heterogeneous Neuropsychiatric Sample. Poster presented at the Annual Conference of the International Neuropsychological Society in Portland, Oregon, Carroll, RT., Steh, B.D., Motivala, S.J. et al. Trauma and Post-Traumatic Stress. UCLA Undergraduate Honors 111: Stress & Coping Psychoneuroimmunology in Older Adults: Autonomic and Immune Pathways Related to Poor Sleep. UCLA Geriatric Psychiatry Grand Rounds Psychoneuroimmunology and Aging. Guest lecture, UCLA Undergraduate Seminar in Gerontology (GE80C), Sleep Disturbance and Immunity: Autonomic mechanisms and mind/body interventions. UCLA Health Psychology Seminar Series, 2005 (Psychology 425). Inflammation and Psychoneuroimmunology. UCLA Department of Psychology, A behavioral practice, Tai Chi Chih, induces acute decreases in sympathetic activation in older adults. Poster presented at the 63 rd Annual American Psychosomatic Society Conference in Vancouver, Canada, Acute psychological stress and proinflammatory cytokines in humans: Differential effects on monocyte intracytoplasmic expression and production. The 11 th Annual Meeting of the Psychoneuroimmunology Research Society. Titisee, Germany, Depression and Psychoneuroimmunology. Invited Presentation at Rotary Club Monthly Meeting, Los Angeles, Major depressive disorder is associated with elevated levels of markers of inflammation and endothelial activation: Implications for coronary artery disease. The 10 th Annual Meeting of Psychoneuroimmunology Research Society, Amelia Island, Florida, Biopsychosocial Assessment in Individuals with Medical Disorders. Invited Presentation at Emperor s College School of Acupuncture, 2003.

5 Sarosh J. Motivala 5 Leptin and cellular and innate immunity in abstinent alcoholics and controls. The 10 th Annual Meeting of Psychoneuroimmunology Research Society, Amelia Island, Florida, Effects of acute stress on immunological and cardiovascular measures. UCLA Anxiety Disorders Research Program, Introduction to Psychology, Course Instructor, University of Miami, Coral Gables, Florida, 1999 (one semester) Cardiac stress responders display greater natural killer cell reactivity to a speech stressor. Poster presented at Society for Behavioral Medicine Conference. New Orleans, Louisiana, Cardiovascular and Immune Reactivity to an Evaluative Speech Stressor in Black, Hispanic, and White Men and Women. Poster presented at Society for Behavioral Medicine Conference. San Francisco, California, Diminished Parasympathetic cardiac input predicts differences in psychosocial functioning. Poster presented at the International Congress of Behavioral Medicine. Washington D.C., BIBLOGRAPHY RESEARCH PAPERS RESEARCH PAPERS (PEER REVIEWED) A. RESEARCH PAPERS PEER REVIEWED 1. Pasic, J., Shapiro, D., Motivala, S.J. & Hui, K. (1998). Blood pressure morning surge and hostility. American Journal of Hypertension, 11(2), Motivala, S.J., Hurwitz, B.E., LaGreca, A., Skyler, J.S. & Schneiderman, N. (1999). Aberrant parasympathetic and hemodynamic function distinguishes a sub-group of psychologically-distressed individuals with asymptomatic Type I Diabetes Mellitus. International Journal of Behavioral Medicine. 6(1), Brownley, K.A., Milanovich, J.R., Motivala, S.J., Schneiderman, N., Fillion, L., Graves, J.A., Klimas, N., Fletcher, M.A. & Hurwitz, B.E. (2001). Autonomic and cardiovascular function in HIV spectrum disease: early indications of cardiac pathophysiology. Clinical Autonomic Research, 11(5), Motivala, S.J., Hurwitz, B.E., Antoni, M., Fletcher, M.A., Llabre, M., Klimas, N., Milanovich, J. & Schneiderman, N. (2003). Psychological distress impacts immunity depending upon level of HIV viral load in Pre- AIDS men and women. Psychosomatic Medicine 65(5), Motivala, S.J., Dang, J., Obradovic, T., Meadows, G.G., Butch, A.W. & Irwin, M. (2003). Leptin and cellular and innate immunity in abstinent

6 Sarosh J. Motivala 6 alcoholics and controls. Alcoholism: Clinical and Experimental Research 27(11), Irwin, M., Rinetti, G., Redwine, L., Motivala, S.J., Dang, J., Ehlers, C. (2004). Nocturnal Proinflammatory Cytokine-Associated Sleep Disturbances in Abstinent African American Alcoholics. Brain, Behavior & Immunity, 18(4), Cole, J.C., Motivala, S.J., Dang, J. Lucko, A., Lang, N., Levin, M., Oxman, M.N., Irwin, M. (2004). Structural Validation of the Hamilton Depression Rating Scale. Journal of Psychopathology and Behavioral Assessment. 26(4), Motivala, S.J., Sarfatti, A., Olmos, L., Irwin, M. (2005). Inflammatory Markers and Sleep Disturbance in Major Depression. Psychosomatic Medicine, 67(2), Cole, J.C., Motivala, S.J., Khanna, D., Lee, J.Y., Paulus, H.E., Irwin, M. (2005). Validation of a Single-Factor Structure and Scoring for the Stanford Health Assessment Questionnaire-Disability Index (HAQ-DI). Arthritis Care and Rheumatism 53(4), Hurwitz, B.E., Brownley, K.A., Motivala, S.J., Milanovich, J.R., Kibler, J.L., Fillion, L., LeBlanc, W., Kumar, M., Klimas, N.G., Fletcher, M.A., Schneiderman, N. (2005) Sympatho-immune anomalies underlying the response to stressful challenge in HIV spectrum disease. Psychosomatic Medicine 67(5), Cole, J.C., Motivala, S.J., Buysse, D.J., Oxman, M.N., Levin, M.J., Irwin, M.R. (2006). Validation of a three-factor scoring model for the Pittsburgh Sleep Quality Index in older adults. Sleep 29, Irwin, M., Valladares, E., Motivala, S.J., Thayer, J., Ehlers, C. (2006). Associations between nocturnal heart rate variability and sleep depth, sleep quality and fatigue in alcohol dependence. Psychosomatic Medicine 68, Cole J.C., Khanna D., Clements P.J., Seibold J.R., Tashkin D.P., Paulus H.E., Irwin M.R., Motivala S.J., Furst D.E. and on behalf of the Scleroderma Lung Study (SLS) and Relaxin Study. (2006) Single-factor scoring validation for the Health Assessment Questionnaire-Disability Index (HAQ-DI) in patients with systemic sclerosis and comparison with early rheumatoid arthritis patients. Quality of Life Research 15(8): Motivala, S.J., Levin, M., Oxman, M.N., Irwin, M. (2006). Impairments in health functioning and sleep quality in older adults with a history of depression. Journal of the American Geriatric Society 54(8), Motivala, S.J., Thayer, J., Sollers, J., Irwin, M. (2006). Tai Chi acutely decreases sympathetic nervous system activity in older adults. Journal of Gerontology: Biological Sciences and Medical Science. 61(11): Irwin, M.R., Olmos, L., Wang, M., Valladares, E. M., Motivala, S.J., Fong, T., Newton, T., Butch, A., Olmstead, R., Cole, S.W. (2007) Cocaine Dependence and Acute Cocaine Induce Decreases of Monocyte Proinflammatory Cytokine Expression across the Diurnal Period: Autonomic Mechanisms. Journal of Pharmacology and Experimental Therapeutics. 320(2):

7 Sarosh J. Motivala Motivala, S.J., Irwin, M.R. (2007). Sleep and Immunity: Cytokine pathways linking sleep and health outcomes. Current Directions in Psychological Science 16(1): O Connor, M.F., Motivala, S.J., Valladares, E., Olmstead, R. and Irwin, M.R. (2007). Sex Differences in Monocyte Expression of IL-6: Role of Autonomic Mechanisms. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 293(1): R Davis, M.C., Zautra, A.J., Younger, J., Motivala, S.J. & Irwin, M.R. (2008) Chronic stress and regulation of cellular markers of inflammation in rheumatoid arthritis: Implications for fatigue. Brain, Behavior and Immunity. 24(1): B. RESEARCH PAPERS PEER REVIEWED (IN PRESS) 20.Valladares, E.M., Motivala, S.J., Ehlers, C., Irwin, M.R. (in press) Sex Differences in Cardiac Sympathovagal Balance and Vagal Tone During Nocturnal Sleep. Sleep. 21. Motivala, S.J., Khanna, D., FitzGerald, J., Irwin, M.R. (in press). Stress activation of cellular markers of inflammation in rheumatoid arthritis: Protective effects of tumor necrosis factor antagonist medications. Arthritis & Rheumatism. C. RESEARCH PAPERS PEER REVIEWED (SUBMITTED) CHAPTERS 1. Motivala, S.J & Irwin, M. (2005). Sleep Deprivation and Immunity. In C. Kushida (Ed.), Sleep Deprivation. New York, New York: Marcel Dekker. ABSTRACTS 2. Motivala, S.J. & Irwin, M. (2007). Sleep and Immune Correlates: Translational research in clinical populations. In S.R. Pandi-Perumal, Daniel P. Cardinali, Georgious Chrousos (Eds.) Neuroimmunology of sleep New York, New York: Springer. 1. Irwin, M., Rinetti, G., Redwine, L., Motivala, S.J., Ehlers, C. (2002). Proinflammatory cytokines and disordered sleep in alcohol dependence. Psychosomatic Medicine, 65, A3-A4. 2. Motivala, S.J., Sarfatti, A., Olmos, L., Irwin, M. (2003). Major depressive disorder is associated with elevated levels of markers of inflammation and endothelial activation: Implications for coronary artery disease. 3. Motivala, S.J., Butch, A., Dang, J., Rinetti, G., Meadows, G., Irwin, M. (2003). Leptin and cellular and innate immunity in abstinent alcoholics and controls. Brain, Behavior and Immunity, 17(3), Motivala S.J., Sarfatti A, Olmos L, Irwin M (2003) Major depressive disorder is associated with elevated levels of markers of inflammation and endothelial activation: implications for coronary artery disease. Brain Behavior and Immunity 17(3),

8 Sarosh J. Motivala 8 5. Irwin M., Rinetti G., Redwine L., Motivala S.J., Ehlers C. (2003). Proinflammatory and disordered sleep in alcohol dependence. Alcoholism: Clinical and Experimental Research 27, 183A. 6. Valladares E., Motivala S.J., Chand-O Neil I., Dang J., Irwin M.R. (2004) Heart rate variability during sleep in recovering alcoholics and controls. Sleep 7. Irwin M.R., Motivala S.J., Sarfatti A. (2004) Inflammatory markers and sleep disturbance in major depression. Psychosomatic Medicine. 66, A2. 8. Irwin M.R., Motivala S.J. (2005) Effects of a behavioral intervention, Tai Chi Chih, on elevated plasma levels of interleukin-6 in older adults. Psychosomatic Medicine 67, A Motivala S.J., Irwin M.R. (2005) A behavioral practice, Tai Chi Chih, induces acute decreases of sympathetic activation in older adults. Psychosomatic Medicine 67, A Irwin M.R., Valladares E., Motivala S.J., Chand-O Neil I., Thayer J.F. (2005) Reduced vagal-related indices of heart rate variability during nocturnal awake and sleep in alcohol dependence. Psychosomatic Medicine 67, A Valladares E.M., Motivala S.J., Chand-O Neil I., Thayer, J.F., Irwin M.R. (2005) Gender differences in heart rate variability during nocturnal wakefulness and sleep. Sleep 23, A43.