CURRICULUM VITAE Winter Falls Ct Manvel, TX United States

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1 CURRICULUM VITAE NAME: PRESENT TITLES: Pedro, MD Associate Professor of Neurology and Pediatrics The University of Texas Medical School at Houston Chief of Neurology Services, Shriners Hospitals Houston Associate Director of Child Neurology Fellowship Program University of Texas Medical School at Houston, Department of Neurology ADDRESS: 2807 Winter Falls Ct Manvel, TX BIRTHDATE: August 28, 1962 CITIZENSHIP: United States UNDERGRADUATE EDUCATION: Pan American University, Edinburg, Texas Bachelor of Science in Biology GRADUATE EDUCATION: The University of Texas Medical School at Houston MD Degree The University of Arkansas for Medical Sciences Arkansas Children s Hospital Department of Pediatrics: Internship and Residency POST GRADUATE EDUCATION: The University of Texas Medical School at Houston Department of Neurology Resident in Pediatric Neurology The University of Texas Medical School at Houston Department of Neurology Fellowship in Pediatric Electromyography and Neuromuscular Disorders 1

2 ACADEMIC APPOINTMENTS: September 2004 to present Associate Professor, Departments of Neurology and Pediatrics The University of Texas Medical School at Houston September 1996 to 2004 Assistant Professor, Departments of Neurology and Pediatrics The University of Texas Medical School at Houston August 1994 August 1996 Clinical Instructor in Child Neurology University of Arkansas Medical Sciences, Department of Pediatrics HOSPITAL APPOINTMENTS: Memorial Hermann Hospital, Medical Center Child Neurology Chief of Pediatric EMG Shriners Hospitals for Children Houston Unit Director of Neurology Services Lyndon B. Johnson Hospital Child Neurology M.D. Anderson Cancer Center Electromyography and Child Neurology LICENSURE: State of Texas, J4323, Active State of Arkansas, E-0203, Inactive BOARD CERTIFICATION: American Board of Psychiatry and Neurology Neurology with Special Qualification in Child Neurology November 1998 to November 2008 PROFESSIONAL ORGANIZATIONS: American Board of Psychiatry and Neurology Subspecialty in Clinical Neurophysiology April 1999 to April 2009 Local: Houston Neurological Society 2

3 Regional: National: Texas Medical Association Child Neurology Society The American Association of Electrodiagnostic Medicine The Peripheral Nerve Society HONORS AND AWARDS: Who s Who Among American Colleges and Universities while at Pan American University, The National Dean s List while at Pan American University, The University Dean s List while at Pan American University, Recipient of The National Hispanic Scholarship Fund 1985,1986 Recipient of The Joseph Collins Foundation Fund 1984 Outstanding Resident Teaching Award in Neurology 1992, 1993 Chief Resident at UT Houston Department of Neurology 1993 Outstanding Faculty Teacher award for The Department of Neurology by the University of Texas Medical School Graduating class of 1998 League of United Latin American Citizens Hispanic Excellence Award, 1998 UT Deans Excellence Award, 1998, 1999, 2002 Outstanding Faculty Teacher award for The Department of Neurology by the University of Texas Medical School Graduating class of 2001 The National Registry of Who s Who, 2000, 2001, 2002 Certificate of Appreciation from Muscular Dystrophy Association 1997,1998, 1999, 2000, 2001, 2002, 2003 Honoree for Fiestas Patrias Grand Ball of Houston, TX, Inc Best Teacher for Medical Neurosciences UT Houston Medical School, 2006 SERVICE ON THE UNIVERSITY OF TEXAS MEDICAL SCHOOL AT HOUSTON COMMITTEES: UT Dept. of Neurology Residency Committee, 1997 to present UT Dept. of Neurology Fellowship Training Committee, 1997 to present Member of Trainee Committee of UT Neurology Departmental Study ACGME Internal Review Committee, 2000 Faculty Student Relations Committee, 2001 to present UT Committee on Committees, 2001 to present UTMS Six year review Committee, 2002 LCME Medical Student Committee, 2002 to present Alternate member at large for MSRDP Board of Directors, 2002-present Faculty Senate Committee, Department of Pediatrics, Staff Quality Review Committee, 2006 to present SERVICE ON UTMS-HOUSTON AFFILIATED HOSPITAL COMMITTEES: Memorial Hermann Hospital Neurology Committee, 1997 to present Memorial Hermann Neuroscience Program Committee, 2004 to present Children s Memorial Hospital Master Planning Committee, 2005 to present Children s Memorial Hospital MSQR committee, 2006 to present 3

4 OTHER COMMITTEES: Pharmacy and Therapeutics at Arkansas Children s Hospital, 1996 Arkansas Regional Organ Recovery Agency, UAMS, Dept of Pediatrics House Staff Committee, Arkansas Children s Hospital, Patient Education Committee, 1996 Founding Member of the Child Neurology Education and Research Foundation, 2000 to present SERVICE TO THE COMMUNITY: Diabetic Camp Physician Volunteer at local Houston elementary school for reading, Lectures on ADHD to Sugarland Areas physicians, nurses, parents 2001 Houston Autism Society, member Muscular Dystrophy Summer Camp Volunteer Physician, 1994, 1995, 1996, 1997, 1998, 1999, 2000, 2001, 2002, 2003, 2004, 2005 CURRENT TEACHING RESPONSIBILITIES: Monthly muscle and nerve biopsy reviews with neuromuscular group and neurophysiology fellows (1 ½ hrs). Monthly neuromuscular journal club with neuromuscular group and neurophysiology fellows (1 ½ hrs). Monthly child neurology journal club with child neurology fellows and other child neurology faculty (3 hrs). Attending physician on child neurology service 4 months a year covering 4 hospitals: Memorial Hermann Children s Hospital, LBJ Hospital, Shriners Hospitals for Children, MD Anderson Cancer Center: Supervision of: Fourth year medical students rotating through Child Neurology Neurology residents rotating through Child Neurology Pediatric residents rotating through Child Neurology Medicine-Pediatric residents rotating through Child Neurology Child psychiatry fellows rotating through Child Neurology Supervision of above trainees 2 half days in general child neurology clinics and subspecialty clinics (neuromuscular clinics) Supervision of Neurophysiology fellows during their electromyography portion of training Weekly Child Neurology Grand Rounds Friday Mornings Supervision of Monthly Shriners Neuromuscular Clinics PUBLICATIONS: ABSTRACTS: 4

5 1. P, Butler IJ. Progressive hemiatrophy and hemineuropathy in a young girl. J Child Neurol P, Butler IJ, Paposozomenos S. Natural history of congenital hypomyelinating neuropathy. J Child Neurol.10(2):165, P, Mrak R, Hoffman E. Merosin deficiency: Clinical presentation and progression in 3 patients with congenital muscular dystrophy. J Child Neurol.11 (2):154, P, Warner LE, Lupski JR, Butler, IJ. Congenital hypomyelinating neuropathy due to a mutation in early growth response transcription factor: EGR2. J Child Neurol. 13:140, P, Morrison LA. Guillain Barre syndrome in 2 neonates. J Child Neurol. 15(3): 196, Shirzadi, S, P, Butler, IJ. Trigeminal myokymia. J Child Neurol. 15(3): 195, Shy ME, Garbern J, P, Lewis RA, Kamholz J. PLP Neuropathies: Proving the Null Hypothesis. Neurology. 54 No. 7 Supplement 3 A70, Ng, YT, P, Butler IJ. An unusual cause of congenital club foot. J Child Neurol.16:207, Acosta Jr F, P, Butler IJ. Distal asymmetric SMA: A unique entity? Presented at Carrell Krusen Symposium in Dallas, TX February 22, P, Heresi G, Butler IJ. Poliomyelitis like illness in a young girl with West Nile virus infection. Presented at Carrel Krusen Symposium in Dallas, TX March 1, REFEREED ORIGINAL ARTICLES IN JOURNALS 1. Glasier CM, Stark JE, Jacobs RF, P, Leitheiser RE, Seibert RW, Siebert JJ. CT and ultrasound imaging of retropharyngeal abscesses in children. American Journal of Neuroradiology 1992;13: P, Bohan TP, Butler IJ, Bhattacharjee MB: Treatment-resistant eosinophilic polymyositis in a child. Journal of Child Neurology 1994;9: P, Slopis JM, Yeakley JW, Vriesendorp FJ: Combined brachial plexus injury and root avulsion after complicated delivery [letter]. Muscle & Nerve 1994;17: Pagliaro LC, P: Polymyositis associated with chronic myelogenous leukemia. Annals of Hematology 1994;68:

6 5. P, Kramer L, Butler IJ: Amoxapine overdose in a young man: A transient mitochondrial abnormality? Pharmacotherapy 1995;15: Williams J, Grant M, Jackson M, Shema SJ, Sharp G, Griebel M, Lange B, P, Bates S. Behavioral descriptors that differentiate between seizure and nonseizure events in a pediatric population. Clinical Pediatrics 1996;5: Pegoraro E, P, Swerdlow SH, et al: Congenital muscular dystrophy with primary laminin alpha2 (merosin) deficiency presenting as inflammatory myopathy. Annals of Neurology 1996;40: Pegoraro E, Marks H, Garcia CA, Crawford T, P, Connolly AM, Fanin M, Martinello F, Trevisan CP, Angelini C, Stella A, Scavina M, Munk RL, Servidei S, Bonnemann CC, Bertorini T, Acsadi G, Thompson CE, Gagnon D, Hoganson G, Carver V, Zimmerman RA, Hoffman EP. Laminin alpha 2 muscular dystrophy: Genotype/phenotype studies of 22 patients. Neurology 1998;51: Warner LE, P, Butler IJ, McDonald C, Keppen L, Koob KG, Lupski JR. Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies. Nature Genetics 1998;18: Williams J, Griebel M, Lange B, Dykman R, Bates S, P, Pihoker C. Does short term AED treatment in children result in cognitive or behavioral changes? Epilepsia 1998;39(10): Tseng BS, Cavin ST, Hoffman EP, Iannaccone ST, P, Booth FW, Butler IJ. Human bhlh transcription factor gene myogenin (MYOG): Genomic sequence and negative mutation analysis in patients with severe congenital myopathies. Genomics 1999;57: Papanicolaou AC, Panagiotis GS, Brier JI, Wheless JW, P, Baumgartner JE, Maggio WW, Gormley W, Constantinou JEC, Butler IJ. Brain plasticity for sensory and linguistic functions: A functional imaging study using MEG with children and young adults. J Child Neurol 2001;16: Boerkoel CF, Takashima H, Garcia CA, Olney RK, Johnson J, Berry K, Russo P, Kennedy S, Teebi AS, Scavina M, Williams LL, P, Butler IJ, Krajewski K, Shy M, Lupski JR: Charcot-Marie Tooth Disease and related neuropathies: Mutation distribution and genotype-phenotype correlation. Ann Neurol 2002; 51: Jordanova A, De Jonghe P, Boerkoel CF, Takashima H, De Vriendt E, Ceutrick C, J Martin J, Butler IJ, P, Papasozomenos S Ch, Terespolski D, Potocki L, Brown CW, Shy M, Rita DA, Tournev I, Kremensky I, Lupski JR, Timmerman V: Mutations in the neurofilament light chain gene (NEFL) cause early onset severe Charcot-Marie-Tooth disease. Brain 2003;126(Pt3): Boerkoel CF, Takashima H, Nakagawa M, Izumo S, Armstrong D, Butler IJ, P, Papasozomenos S Ch, Stern LZ, Lupski JR: CMT4A: Identification of a Hispanic Founder mutation. Ann Neurol 2003;53:

7 16. Shy ME, Hobson G, Jain M, Boespflug-Tanguy O, Garber J, Sperle K, Li W, Gow A, Rodriguez D, Bertini E, P, Krajewski K, Lewis R, Kamhoz J. Schwann Cell Expression of PLP1 but Not DM20 is necessary to prevent neuropathy. Ann Neurol 2003;53: P, Butler IJ. Trigeminal myokymia in a young girl. Journal of Child Neurology. 2003;18(8): Inoue K, Khajavi M, Ohyama T, Hirabayashi S, Wilson J, Reggin JD, P, Butler IJ, Wilkinson MF, Wegner M, Lupski JR. Molecular mechanism for distinct neurological phenotypes conveyed by allelic truncating mutations. Nat Genet Apr;36(4): Heresi GP, P, Mazur LJ, Butler IJ, Murphy JR, Cleary TG. Poliomyelitis-like syndrome in a child with West Nile virus infection. Pediatr Infect Dis J Aug;23(8): Saifi GM, Szigeti K, Wiszniewski W, Shy ME, Krajewski K, Hausmanowa- Petrusewicz I, Kochanski A, Reeser S, P, Butler I, Lupski JR. SIMPLE mutations in Charcot-Marie-Tooth disease and the potential role of its protein product in protein degradation. Hum Mutat Apr;25(4): Verhoeven K, Claeys KG, Zuchner S, Schroder JM, Weis J, Ceuterick C, Jordanova A, Nelis E, De Vriendt E, Van Hul M, Seeman P, Mazanec R, Saifi GM, Szigeti K, P, Butler IJ, Kochanski A, Ryniewicz B, De Bleecker J, Van den Bergh P, Verellen C, Van Coster R, Goemans N, Auer-Grumbach M, Robberecht W, Milic Rasic V, Nevo Y, Tournev I, Guergueltcheva V, Roelens F, Vieregge P, Vinci P, Moreno MT, Christen HJ, Shy ME, Lupski JR, Vance JM, De Jonghe P, Timmerman V. MFN2 mutation distribution and genotype/phenotype correlation in Charcot-Marie-Tooth type 2. Brain Aug;129(Pt 8): Gruber SA, P, Swinford RD, Prashner HR, Clifton J, Henry MH. Livingdonor nerve transplantation for global obstetric brachial plexus palsy. J Reconstr Microsurg May;22(4): EDITORIALS: 7

8 P. Minorities in neurology, editorial. Journal for Minority Medical Students. Spring BOOK CHAPTERS P, Butler IJ. Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy. Neurocutaneous Disorders, Ed. Roach ES, Miller VS. Cambridge University Press, UK, In press, P, Butler IJ. Neuroleptic malignant syndrome and malignant hyperthermia. Treatment of Pediatric Neurologic Disorders, Ed. Singer H, Kossoff EH, Crawford TD, Hartman AL. Marcel Dekker, Inc. New York, In press BOOK REVIEWS (sole author): 1. Biopsy Pathology of Muscle, Second edition by Michael Swash and Martin S. Schwarz in 1991 by Carolina Academic Press, Durham, NC. Printed in JCN, Child and Adolescent Neurology, First edition by Ronald B. David in 1998 by Doody Publishing, Oak Park, Illinois. Printed in Doody s Health Sciences Book Review Journal. 3. Neuromuscular Diseases During Development, Edited by F. Cornelio, G. Lanzi, and E. Fedrizzi in 1997 by John Libbey & Company Ltd, London, England. In press. INVITED LECTURES: 1. Hospital Veinte de Noviembre, Departamento de Pediatria, Mexico City: El infante flacido (The floppy infant) May 17, IV Annual Mexican Child Neurology Society, San Luis Potosi, San Luis Potosi, Mexico: Experiencia con Vigabatrina en epilepsia May 18, Introducing Genetics into Clinical Practice, Neuromuscular Diseases, Tulsa, Oklahoma, Hillcrest Medical Center, October 4, UTMS - Houston Neurology Grand Rounds: EGR2 and Congenital Hypomyelinating Neuropathy Feb. 27,

9 5. UTMS - Houston Orthopaedics Grand Rounds: Child Neurology for the Orthopaedic Surgeon Sept 23, UTMS Houston Pediatrics Grand Rounds: Neuromuscular Update Jan 18, UTMS Houston Department of Pediatrics CME Update: Update on Management and Treatment of Childhood Headaches, Shriners Hospitals Annual Lectureship, Houston: Evaluation of abnormal tone, Texas Children s Hospital Critical Care Morning rounds: Weakness in the Intensive Care Unit, Apr 12, UT-Houston Neurology Grand Rounds: CMT, Nov. 2, Texas Neurologic Society: Impact of Neurogenetics on evaluation of pediatric neuromuscular disorders, Feb 22, XI Annual Mexican Child Neurology Society: "Charcot Marie Tooth Syndrome", Oaxaca, Mexico, May 15-18, 2002 OTHER ACTIVITIES: 1. Faculty representative for Clinical Orientation for Parents and Spouses for UT- Houston 3 rd year medical students 1999, 2001, Muscular Dystrophy Camp Physician, 1997, 1998, 1999, 2000, 2001, 2002, Volunteer Staff at Shriners Hospital for Children 1997 to Preceptor for UT Medical School Summer Enrichment Program 1997, 1998, 1999, 2001, 2002, Facilitator for Evidence Based Learning Course for 4 th year medical students, Interviewer for UT Medical School at Houston candidates , 2000, Interviewer for UT Neurology Residency Program 1995 to present 8. Interviewer for UT Neurology Fellowship Program 1995 to present 9. Interviewer for UT Dept of Pediatrics Faculty Positions 1995 to present 10. Supervised the initiation of a neurology network with capacities 11. Webmaster for the Department of Neurology ( present) 12. UT - Houston Clinical Epidemiology course every Wednesday evening 5:00 PM - 7:00 PM from August 2001 to May Applied for UT - Houston Master Teacher program, Faculty volunteer for the Clinical Performance Examination (CPX) of fourth year students, April Ad Hoc Reviewer for Journal of Child Neurology 16. Volunteer (Actor) for HEADS UP Program for regional 7th grade videotape educational course on neurological disorders in conjunction with UT School of Public Health - Houston and John P. McGovern Museum of Health and Medical Science. 17. Preceptor for the JAMP program: 2004, Lecturer for Life Flight Program: Pediatric Seizures and Management,

10 Television Appearances Houston Cable Network 1998: Muscular Dystrophy Camp NBC Today Show May 2001: Living donor adult to pediatric nerve transplantation for severe brachial plexopathy KHOU Medical Reports, May 2001: Living donor adult to pediatric nerve transplantation for severe brachial plexopathy Univision Evening News May 2001: Living donor adult to pediatric nerve transplantation for severe brachial plexopathy (in Spanish). LANGUAGES: Fluent English and Spanish INNOVATIVE PROJECTS: One of several specialists involved in first adult to child living donor nerve transplant for severe brachial plexus injury in infant less than 12 months of age. I served as the neuromuscular specialist performing serial electrophysiologic testing and clinical examinations and documenting progress and recommending further intervention. One of several experts evaluating patients with arthrogryposis multiplex congenita at Shriners Hospitals for Children, Houston Unit. We plan on determining the genetic and neurologic causes of such through electrophysiologic testing, neuroimaging and possible muscle/nerve biopsies. The genetic causes are also being investigated through a multidisciplinary approach including, genetics, orthopoedics, physical and occupational therapy, and pediatric neurology. RESEARCH INTERESTS: Unclassified Inherited Pediatric Neuropathies Brachial Plexus injuries in neonates, evaluation and treatment. Arthrogryposis Multiplex Congenita ADDITIONAL SKILLS: Performance of EMG/NCS in adults and children Performance of muscle and nerve biopsies. CLINICAL PROJECTS: Co-Established the UT- Memorial Hermann Comprehensive Brachial Plexus Program OTHER: Interview medical student candidates for UT Houston, 1996 to present Interview pediatric department faculty candidates, 1996 to present 10

11 Interview neurology department faculty candidates, 1996 to present Interview neurology resident candidates, 1995 to present Interview neurophysiology fellowship candidates, 1996 to present 11