KARGER. European Studies on the Incidence of Dementing Diseases

Transcription

1 European Studies on the Incidence of Dementing Diseases A Report of the EURODEM Research Group Guest Editors L.J. Launer, Rotterdam C. Brayne, Cambridge J-F. Dartigues, Bordeaux A. H ofm an, Rotterdam 6 figures, 44 tables, 1992 KARGER

2 Neuroepidemiology Vol. 11, Supplement 1, 1992 The support of the Commission of the European Community, Brussels, to the EURODEM Concerted Action Epidemiology of Dementia is gratefully acknowledged. S. Karger Medical and Scientific Publishers Basel München Paris London New York New Delhi Bangkok Singapore Tokyo Sydney Drug Dosage The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text arc in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center (see Information for Readers and Subscribers ). Copyright 1992 by S. Kargcr AG, P.O. Box, CH-4009 Basel (Switzerland) Printed in Switzerland on acid-free paperby Thiir AG OITsetdruck, Pratteln ISBN II

3 Members of the EURODEM Research Group EURODEM Incidence Conferences Bordeaux, France, 1989 Cambridge, UK, 1990 Dr. A. Alperovitch INSERMU , Avenue Paul-Vaillant Couturier F Villejuif Cedex (France) Prof. L. Amaducci SMID Centre Via il Prato Florence (Italy) Dr. G. de Backer Academisch Ziekenhuis de Pintelaan Department of Cardiology B-9000 Gent (Belgium) Prof. F. Boiler INSERM U 324 Centre Paul Broca 2ter, rue d Alesia F Paris (France) Dr. C. Brayne Department of Community Medicine Cambridge University Medical School Addenbrooke s Hospital Cambridge CB2 2QQ (UK) Dr. M.M.B. Breteler POBox 1738 Ms. C. Chadwick PO Box 147 Dr. J.J. Claus Mr. D. Clayton MRC Unit Fairview Lodge 5 Shaftesbury Road Cambridge CB2 2BW (UK) Mr. D. Commenges Département d informatique Médicale 146, rue Léo-Saigat Prof. B. Cooper Zentralinstitut für Seelische Gesundheit Postfach D-W-6800 Mannheim 1-J5 (FRG) Prof. J.R.M. Copeland PO Box 147 Prof. J-F. Dartigues Département d informatique Médicale 146, rue Léo-Saigat Prof. N.E. Day MRC Unit Fairview Lodge 5 Shaftesbury Road Cambridge CB2 2BW (UK) Mr. M. Dewey PO Box 147 Dr. L. Fratiglioni Karolinska Institute Huddinge University Hospital S-I4186 Huddinge (Sweden) III

4 Ms. M. Gagnon Département d'informatique Médicale 146. rue Léo-Saigat Prof. O. Hagnell Department of Social and Forensic Psychiatry University of Lund St. LarsSjukhus Box 646 S Lund (Sweden) Prof. A. Hofman Dr. C. Jagger Department of Community Health Clinical Sciences Building Leicester Royal Infirmary PO Box 65 Leicester LE2 7LX (UK) Dr. C. Jonker Afdeling Psychiatrie Valeriusplein 9 NL-1075 BG Amsterdam Prof. D.W. Kay MRC Neurochemical Pathology Unit Newcastle General Hospital Wcatgate Road Newcastle upon Tyne NE4 6BE (UK) Dr. P. Kragh-Sorensen Odense Hospital DK-5000 Odense C (Denmark) Dr. L.J. Launer NL- Prof. A. Lobo Departamento Medicina y Psiquiatría Pta 11. Hospital Clínico Universitario E Zaragoza (Spain) Dr. G. Livingston Institute of Psychiatry de Crespigny Park, Denmark Hill London SE5 8AF(UK) Prof. A.H. Mann Institute of Psychiatry de Crespigny Park. Denmark Hill London SE5 8AF(UK) Dr. M. Martinez-Lage Neuronasa Cortes de Navarra 1-4 E Pamplona (Spain) Dr. K. Morgan Department of Health Care of the Elderly Queens Medical School Nottingham NG7 2UH (UK) Dr. H. Nielsen Odense University Hospital Department of Neurology DK-5000 Odense C (Denmark) Dr. D.W. O Connor Hughes Hall Mortimer Road Cambridge CB1 2EW(UK) Prof. J.M. Orgogozo Service de Neurologie Hospital Pellegrin-Tripode Dr. J.J. Pere Laboratoires Sandoz 14, Bid Richelieu F Rueil Malmaison (France) Dr. M. Roelands Welfare Foundation Lange Lozanastraat 223, bus 2 B-2018 Antwerp (Belgium) Dr. W.A. Rocca SMID Centre Via il Prato Florence (Italy) Prof. R. Salamon Département d informatique Médicale 146, rue Léo-Saigat Dr. P. Saunders POBox 147 Dr. P. Saz Departamento Medicina y Psiquiatría Pta 11, Hospital Clínico Universitario E Zaragoza (Spain) Dr. A. da Silva Droux Unidade de Saude Mental do Gondomar DO Hospital Conde Ferreira Av. Gen. Humberto Delgado 1275 P Gondomar (Portugal) Dr. C.M. van Duijn Prof. B. W inblad Karolinska Institute Huddinge University Hospital S Huddinge (Sweden) Members of the EURODEM Research Group

5 Contents Launer, L.J.; Brayne, C.; Dartigues, J-F.; Hofman, A. Launer, L.J. Preface New Studies Overview of Incidence Studies of Dementia Conducted in Europe l 2 Dartigues, J-F.; Gagnon, M.; Barberger-Gateau, P.; Letenneur, L.; Comraenges, D.; Sauvel, C.; Michel, P.; Salamon, R. The Paquid Epidemiological Program on Brain Ageing 14 Amaducci, L. Breteler, M.M.B.; van den Ouweland, F.A.; Grobbee, D.E.: Hofman, A. F ratig lio n i, L.; V iita n e n, M.; Backman, L.; Sandman, P-O.; Winblad, B. Chadwick, C.; on behalf of the MRC Multicentre Study Group Saunders, P.A.; Copeland, J.R.M.; Dewey, M.E.; Larkin, B.A.; Scott, A. Roelands, M.; Baro, F.; Dom, H.; Wostyn, P. Lobo, A.; Saz, P.; Marcos, G.; Morales, F. Italian Longitudinal Study on Ageing; Incidence Study of Dementia A Community-Based Study of Dementia: The Rotterdam Elderly Study Occurrence of Dementia in Advanced Age: The Study Design of the Kungsholmen Project The MRC Multicentre Study of Cognitive Function and Ageing: A EURODEM Incidence Study in Progress Alpha: The Liverpool MRC Study of the Incidence of Dementia and Cognitive Decline Epidemiology Research on Dementia in Antwerp, Belgium Incidence of Dementia and Other Psychiatric Conditions in the Elderly: Zaragoza Study v

6 Jagger, C; Clarke, M.; Anderson, J. Incidence of Dementia in Melton Mowbray: A Proposed Study and Its Problems Recent Findings 57 Hagneil, 0.; Öjesjö, L.; Rorsman, B. Incidence of Dementia in the Lundby Study 61 Muir, M.S.; Brayne, C. Brayne, C; Huppert, F.; Paykel, E.; Gill, C. Mann, A.H.; Livingston, G.; Boothby, H.; Blizard, R. Morgan, K.; Lilley, J.; Arie, T.; Byme, J.; Jones, R.; Waite, J. Copeland, J.R.M.; Dewey, M.E.; Davidson, I.A.; Saunders, P.A.; Scott, A. A Longitudinal Study in Progress: A Five-Year Follow-Up of Women Aged Years Living in a Rural Community The Cambridge Project for Later Life: Design and Preliminary Results The Gospel Oak Study: The Prevalence and Incidence of Dementia in an Inner City Area of London Incidence of Dementia: Preliminary Findings from the Nottingham Longitudinal Study of Activity and Ageing Geriatric Mental State-AGECAT: Prevalence, Incidence and Long-Term Outcome of Dementia and Organic Disorders in the Liverpool Study of Continuing Health in the Community Methodologie Issues Brayne, C.; Day, N.; Gill, C. Methodological Issues in Screening for Dementia 88 Kay, D.W.K.; Blessed, G.; Black, S.E. Methodological Problems with Diagnosis of Dementia in Community Surveys: The Choice of Items to Study Higher Functions 94 Alpérovitch, A.; Hauw, J.J. Neuropathological Diagnoses in Epidemiologic Studies 100 Risk Factors van Duijn, C.M.; Hofman, A.; for the EURODEM Risk Factors Research Group Launer, L.J.; Brayne, C.; Breteler, M.M.B. Risk Factors for Alzheimer s Disease: The EURODEM Collaborative Re-Analysis of Case Control Studies Epidemiologic Approach to the Study of Dementing Diseases: A Nested Case-Control Study in European Incidence Studies of Dementia Launer, L.J.; Brayne, C.; Dartigues, J-F.; Hofman, A. Epilogue 119 Author Index 122 VI Contents