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1 Further Section Neuroepidemiology 1992;11:00I-0VI Title page / Table of Contents European Studies on the Incidence of Dementing Diseases A Report of the Guest Editors EURODEM L.J. Launer, Rotterdam Research Group C. Brayne, Cambridge J-F. Dartigues, Bordeaux A. Hofman, Rotterdam 6 figures, 44 tables, 1992
2 KARG E R Neuroepidemiology Vol. 11, Supplement 1,1992 The support of the Commission of the European Community, Brussels, fo the EURODEM Concerted Action Epidemiology of Dementia is gratefully acknowledged. S. Karger Medical and Scientific Publishers Basel Munchen Paris London New York New Delhi Bangkok Singapore Tokyo Sydney Drug Dosage The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center (see 'Information for Readers and Subscribers'). Copyright 1992 by S. Karger AG, P.O. Box, CH-4009 Basel (Switzerland) Printed in Switzerland on acid-free paper by Thtir AG Offsetdruck, Pratteln ISBN J II Members of the EURODEM Research Group
3 EURODEM Incidence Conferences Bordeaux, France, 1989 Cambridge, UK, 1990 Dr. A. Alp6rovitch INSERMU169 16, Avenue Paul-Vaillant Couturier F Villejuif Cepx (France) Prof. L. Amaducci SMID Centre ViailPrato Florence (Italy) Dr. G. de Backer Academisch Ziekenhuis de Pintelaan Department of Cardiology B-9000 Gent (Belgium) Prof. F. Boiler INSERMU324 Centre Paul Broca 2ter, rue d*alesia F Paris (France) Dr. C. Brayne Department of Community Medicine Cambridge University Medical School Addenbrooke's Hospital Cambridge CB2 2QQ (UK) Dr. M.M.B. Breteler Biostatistics PO Box DR Rotterdam Ms. C. Chadwick Department of Psychiatry The University of Liverpool Royal Liverpool Hospital 6 Abercromby Square PO Box 147 Liverpool L69 3BX (UK) Dr. J. J. OffiM Biostatistics PO Box DR Rotterdam Mr. D. Clayton MRC Biostatistics Unit Fairview Lodge 5 Shaftesbury Road Cambridge CB2 2BW (UK) Mr. D. Commenges INSERMU330 University de Bordeaux II Departement dtnformatique Medicale 146, rue L o-saigat F Bordeaux Cedex (France) Prof. B. Cooper Zentralmstitut fur Seelische Gesundheit Postfach
4 D-W-6800 Mannheim 1-J5 (FRG) Prof. J.R.M. Copeland Department of Psychiatry The University of Liverpool Royal Liverpool Hospital 6 Abercromby Square PO Box 147 Liverpool L69 3BX (UK) Prof. J-F. Dartigues INSERMU330 Universite" de Bordeaux II Departement dtnformatique Medicale 146, rue L o-saigat F Bordeaux Cedex (France) Prof. N.E. Day MRC Biostatistics Unit Fairview Lodge 5 Shaftesbury RoadCambridge CB2 2BW (UK) Mr. M. Dewey Department of Psychiatry The University of Liverpool Royal Liverpool Hospital 6 Abercromby SquarePO Box 147Liverpool L69 3BX (UK) Dr. L. Fratiglioni Karolinska Institute Huddinge University Hospital S Huddinge (Sweden) III Ms. M. Gagnon INSERMU330 University de Bordeaux II Departement d'lnformatique Medicale 146, rue L6o-Saigat F Bordeaux Cedex (France) Prof. O. Hagnell Department of Social and Forensic Psychiatry University of Lund St. Lars Sjukhus Box 646 S Lund (Sweden) Prof. A. Hofman Biostatistics PO Box DR Rotterdam Dr. C. Jagger Department of Community Health Clinical Sciences Building Leicester Royal Infirmary POBox65 Leicester LE2 7LX (UK) Dr. C. Jonker Afdeling Psychiatrie Valeriusplein 9 NL-1075 BG Amsterdam
5 Prof. D.W. Kay MRC Neurochemical Pathology Unit Newcastle General Hospital Weatgate Road Newcastle upon Tyne NE4 6BE (UK) Dr. P. Kragh-Sorensen Odense Hospital Department of Psychiatry DK-5000 Odense C (Denmark) Dr. L.J. Launer [Biostatistics PO Box 1738 NL-3000 DR Rotterdam Prof. A. Lobo Departamento Medicina y Psiquiatria Pta 11, Hospital Clinico Universitario E Zaragoza (Spain) Dr. G. Livingston Institute of Psychiatry de Crespigny Park, Denmark Hill London SE5 8AF (UK) Prof. A.H. Mann [institute of Psychiatry de Crespigny Park, Denmark Hill London SE5 8AF (UK) Dr. M. Martinez-Lage Neuronasa Cortes de Navarra 1 4 E Pamplona (Spain) Dr. K. Morgan Department of Health Care of the Elderly Queens Medical School Nottingham NG7 2UH (UK) Dr. H. Nielsen Odense University Hospital Department of Neurology DK-5000 Odense C (Denmark) Dr. D.W. O'Connor Hughes Hall Mortimer Road Cambridge CB1 2EW (UK) Prof. J.M. Orgogozo Service de Neurologie Hospital Pellegrin-Tripode F Bordeaux Cedex (France) Dr. J. J. Pere Laboratoires Sandoz 14, Bid Richelieu F Rueil Malmaison (France) Dr. M. Roelands Welfare Foundation Lange Lozanastraat 223, bus 2 B-2018 Antwerp (Belgium) Dr. W.A. Rocca SMID Centre ViailPrato Florence (Italy) Prof. R. Salamon INSERMU330 University de Bordeaux II Departement dtnformatique Medicale 146, rue L6o-Saigat
6 F Bordeaux Cedex (France) Dr. P. Saunders Department of Psychiatry The University of Liverpool Royal Liverpool Hospital 6 Abercromby Square PO Box 147 Liverpool L69 3BX (UK) Dr. P. Saz Departamento Medicina y Psiquiatria Pta 11, Hospital Clinico Universitario E Zaragoza (Spain) Dr. A. da Silva Droux Unidade de Saude Mental do Gondomar DO Hospital Conde Ferreira Av. Gen. Humberto Delgado 1275 P Gondomar (Portugal) Dr. CM. van Duijn Biostatistics P03ox DR Rotterdam Prof. B. Winblad Karolinska Institute Huddinge University Hospital S Huddinge (Sweden) IV Members of the EURODEM Research Group Contents Launer, L.J.; Brayne, C; Dartigues, J-F.; Hofman, A. Preface l New Studies Launer, L.J. Overview of Incidence Studies of Dementia Conducted in Europe 2
7 Dartigues, J-F.; Gagnon, M.; Barberger-Gateau, P.; Letenneur, L.; Commenges, D.; Sauvel, C; Michel, P.; Salamon, R. The Paquid Epidemiological Program on Brain Ageing 14 Amaducci, L. Italian Longitudinal Study on Ageing: Incidence Study of Dementia 19 Breteler, M.M.B.; van den Ouweland, F.A.; Grobbee, D.E.; Hofman, A. A Community-Based Study of Dementia: The Rotterdam Elderly Study 23 Fratiglioni, L.; Viitanen, M.; Backman, L.; Sandman, P-O.; Winblad, B. Occurrence of Dementia in Advanced Age: The Study Design of the Kungsholmen Project 29 Chadwick, C; on behalf of the MRC Multicentre Study Group The MRC Multicentre Srady of Cognitive Function and Ageing: A EURODEM Incidence Study in Progress 37 Saunders, P. A.; Copeland, J.R.M.; Dewey, M.E.; Larkin, B.A.; Scott, A. Alpha: The Liverpool MRC Study of the Incidence of Dementia and Cognitive Decline 44 Brands, M.; Baro, F.; Dom, H.; Wostyn, P. Epidemiology Research on Dementia in Antwerp, Belgium 48 Lobo, A.; Saz, P.; Marcos, G.; Incidence of dementia and Other Psychiatric 52 Morales, F. Conditions in the Elderly: Zaragoza Study dagger, C; Clarke, M.; Anderson, J. Incidence of Dementia in Melton Mowbray: A Proposed Study and Its Problems 57 Recent Findings Hagnell, 0.; Ojesjo, L.; gasman, B. Incidence of Dementia in the Lundby Study 61 Muir, M.S.; Brayne, C. A Longitudinal Study in Progress: A Five-Year Follow-Up of Women Aged Years Living in a Rural Community 67 Brayne, C; Huppert, F.; Paykel, E.; Gill, C. The Cambridge Project for Later Life: Design and Preliminary Results
8 71 Mann, A.H.; Livingston, G.; Boothby, H.; Blizard, R. The Gospel Oak Study: The Prevalence and Incidence of Dementia in an Inner City Area of London 76 Morgan, K.; Lilley, J.; Arie, T.; Byrne, J.; Jones, R.; Waite, J. Incidence of Dementia: Preliminary Findings from the Nottingham Longitudinal Study of Activity and Ageing 80 Copeland, J.R.M.; Dewey, M.E. Davidson, LA.; Saunders, PA.; Scott, A. Geriatric Mental State-AGECAT: Prevalence, Incidence and Long- Term Outcome of Dementia and Organic Disorders in the Liverpool Study of Continuing Health in the Community 84 Methodologic Issues Brayne, C; Day, N.; Gill, C. Methodological Issues in Sheening for Dementia 88 Kay, D.W.K.; Blessed, G.; Black, S.E. Methodological Problems withj^^g^osis of Dementia in Community Surveys: The Choice of Items to Study Higher Functions 94 Alperovitch, A.; Hauw, J.J. Neuropathological Diagnoses in Epidemiologic Studies 100 Risk Factors van Duijn, CM.; Hofman, A.; for the EURODEM Risk Factors Research Group Risk Factors for Alzheimer's Disease: The EURODEM Collaborative Re-Analysis of Case Control Studies 106 Launer, L.J.; Brayne, C; Ecleler, M.M.B. Epidemiologic Approach to the Study of Dementing Diseases: A Nested Case-Control Study in European Incidence ^gdies of Dementia 114 Launer, L.J.; Brayne, C; Dartigues, J-F.; Hofman, A. Epilogue 119 Author Index 122 V. VI Contents
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