33% of adult MEN present sexual disorders (especially premature ejaculation) with a prevalence of erectile dysfunction (14%).
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1 GUNA s Pharmacology Insights for Sexual Wellness: love, sex and their molecules. New possibilities from Low Dose Medicine. Alessandro Perra, Scientific Director of Guna-Italy April 25 th Central European Time. 1 Why 2 Guna Mars and Guna Venus for sexual disorders 19% of WOMEN of childbearing age and 40% of women who are going through menopause present sexual disorders especially in terms of sexual desire and excitation (Laumann et al, 1994 Rosen et al. 1993). 33% of adult MEN present sexual disorders (especially premature ejaculation) with a prevalence of erectile dysfunction (14%). and maybe much more.
2 Why 2 Guna Mars and Guna Venus for sexual disorders Because understanding the biological bases of love and sex will help millions of men and women who are not able to fall in love or for love suffer or will help them to live their emotions and sex life more serenly and intensely Because today we can handle the molecules of love and sex. Because today we know many aspects of the chemistry of love and knowing and understanding the biological bases of love will not take off fascination from it. Because for love and sex we enjoy or die or become sick. From where we have started at Guna Laboratories 2 Meds active both on mind and body (PNEI Network) 2 Meds able to act on all the sex s phases Different sexuality of women and men Centrality of Dopamine and Oxytocine
3 2 Meds able to act on all the sex s phases SATISFACTION ORGASM AROUSAL DESIRE AND ATTRACTION Differente sexuality of men and women DOPAMINE OXYTOCIN
4 Centrality of Dopamine and Oxytocine SATISFACTION ORGASM AROUSAL SEROTONIN DOPAMINE OXYTOCINE SEROTONIN OXYTOCINE DOPAMINE DESIRE AND ATTRACTION DOPAMINE Neuro-chemistry of sex attraction What do food, sex and drugs have in common?
5 Neuro-chemistry of sex attraction Food, sex and drugs stimulate mesolimbic* DOPAMINERGIC neurons. Limbic System: part of the brain that controls emotions, mood and passions DOPAMINE Attention Motivation Desire and attraction Passion Reward Disinhibition Exaltation Euphoria Delirium
6 Activation of mesolimbic dopaminergic neurons by drugs HEROIN _ COCAINE _ GABA Re-uptake of Dopamine Activation of mesolimbic dopaminergic neurons by natural stimuli FOOD SEX Nucleus accumbens D O P A M I N E Dipartimento Scientifico Guna S.p.a.
7 Trend of Vasopressin during the different phases of sex in MALE AND FEMALE SUBJECTS Male subjects Female subjects
8 Trend of Epinephrine and Norepinephrine during the different phases of sex in MALE AND FEMALE SUBJECTS Male subjects Female subjects Trend of Prolactin during the different phases of sex in MALE SUBJECTS
9 Trend of Oxytocine during the different phases of sex in MALE SUBJECTS Plasma Oxytocine pmol/l Baseline Arousal Orgasm 10 mins post 30 mins post Trend of Oxytocine during the different phases of sex in FEMALE SUBJECTS Plasma Oxytocine pmol/l Baseline Arousal Orgasm 10 mins post 30 mins post
10 In Physiological Regulating Medicine EVERY DISEASE IS THE EXPRESSION, THE CONSEQUENCE OF CHANGED CONCENTRATION OF MESSENGER MOLECULES 20
11 DISEASE HYPER-CONCENTRATION HEALTH 4C X6 PHYSIOLOGICAL CONCENTRATION HYPO-CONCENTRATION DISEASE C O P E Cytokines & Cells Online Pathfinder Encyclopedia Version 26.7 (Spring 2011 Edition) GUNA MARS and GUNA VENUS are natural, innovative, easy to use and have no side effects: a discovery of Italian Research in the field of Molecular Biology and Sexology and their effectiveness and safety profiles are demonstrated by clinical trials.
12 GUNA-MARS Clinical evaluation Lupardini M. -Mars and venus: the low dose mediators of sexuality managing the hypoactive sexual desire disorder (HSDD) with the aid of physiological regulating medicine. Physiological Regulating Medicine 1/2010: Clinical single blind randomized controlled trial. Group verum: 15 men (age 42-58) Group placebo: 15 men (age 42-58) Evaluation at time zero and after 2 months as per recommendations in the International Index of Erectile Disfunction (IIEF-15) Diagnose evaluation: lack of sexual desire, erectil disfunction, orgasm disorders, reduced sexual satisfaction during intercourse, reduced wellbeing
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14 GUNA-VENUS Clinical evaluation Lupardini M. -Mars and venus: the low dose mediators of sexuality managing the hypoactive sexual desire disorder (HSDD) with the aid of physiological regulating medicine. Physiological Regulating Medicine 1/2010: Clinical single blind randomized controlled trial Group verum: 15 women (age 34-51) Group placebo: 15 women (age 34-51) Evaluation at time zero and after 2 months as per recommendations in the Female Sexual Function Index (FSFI) Diagnose evaluation: lack of sexual desire, excitation disorders, reduced lubrication, orgasm disorders, reduced sexual satisfaction during intercourse, pain experienced during intercourse.
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17 GUNA-MARS and GUNA-VENUS DIRECTIONS 1 dose* a day -preferibly in the eveningusually 30 mins before or 1 hour after eating, daily, for 2 months. *Take the tube and turn the white milled cap. You could meet some resistance: in fact, every tube is sealed to guarantee its integrity. If you have difficulties, try to move the white milled cap back and forth, after which turn to open it. Once you opened the tube, pull out the transparent wrapping, remove the white cap and pour the granules content under the tongue. 33 Guna Mars and Guna Venus Wrap up in few words Sexual Wellness, Sex Drive, Sex enhancement booster, Arousal, Sexual Desire, Intensity, Sexual Satisfaction, Well-being, Couple relationship, Natural, No side effects, Easy to use, Efficacy proven by clinical studies, Excellent compliance.
18 References Lupardini M. -Mars and Venus: the low dose mediators of sexuality managing the Hypoactive Sexual Desire Disorder (HSDD) with the aid of Physiological Regulating Medicine. Physiological Regulating Medicine 1/2010: Rosen R.C., et Al. The International index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology, 1997, 49: Rosen R.C. et Al. The female sexual Function Index (FSFSI): a multidimensional self-reported instrument for the assessment of female sexual function, J. of Sex Marital Therapy, 2000, 26: Gessa GL. I neurotrasmettittori dell attrazione sessuale. MTD It J Addict 30 Marzo 2001 Michael S.Exton et al. Cardivascular and Endcrine Alterations After Masturbation-Induced Orgasm in Women. Psychosomatic Medicine 61: (1999) T H C Kruger et al. Specifity of the neuroendocrine response to orgasm during sexual arousal in men. Journal of Endocrinology (2003) 177, Company Laeflet: From Research in Molecular Biology a New Therapeutic Concept for Sexual Wellness. Guna Mars and Guna Venus. Guna Laboratori (2010) Save your time! Take your DIPLOMA of Specialist in Physiological Regulating Medicine
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