전수면박탈이정상성인남자의인지기능에미치는효과 *

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1 KISEP Original Articles J Korean Neuropsychiatr Assoc Vol 38, No 2 전수면박탈이정상성인남자의인지기능에미치는효과 * 이흥표 ** 김대진 *** 고효진 *** 김수용 **** 이성필 *** Effects of Total Sleep Deprivation on the Cognitive Function in the Normal Adult Male Subjects* Heung pyo Lee, M.A.,** Dai-Jin Kim, M.D.,*** Hyo Jin Go, M.D.,*** Soo Yong Kim, Ph.D.,**** Sung Phil Lee, M.D.*** 연구목적 : 방법 : 결과 : 결론 : 중심단어 Department of Psychology, The Catholic University of Korea, Daejeon St. Mary Hospital, Taejon Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul Department of Physics, Korea Advanced Institute of Science and Technology, Taejon Corresponding author 국문초록 325

2 서론 1. 연구대상 방 2. 연구방법 1) 실험및분석절차 법 326

3 Table 1. LNNB clinical scale, calculation and digit symbol scores before and after sleep deprivationsn18 Meanstandard deviation t-value p Before SD After SD LNNB clinical scale Motor function * Rhythm * Tactile function NS Visual NS Receptive speech * Expressive speech ** Writing NS Reading NS Articulation NS Memory * Intellectual process NS Calculation NS K-WAIS Digit spanforward NS Digit spanbackward NS *p.05, **p.01, NSNot significant SDSleep deprivation 3. 검사도구 1) LNNB 2) 숫자외우기와산수 4. 통계방법 결 1. 수면박탈을전후로한 LNNB 임상척도및숫자외우기, 산수의비교 과 327

4 Table 2. LNNB summary scale and localization scores before and after sleep deprivationsn18 Summary scale LNNB Localization scale Meanstandard deviation Before SD After SD t-value Pathognomic ** Left hemisphere NS Right hemisphere NS Profile elevation NS Impairment * Left H frontal NS Left H sensorimotor * Left H parietal-occipital NS Left H temporal NS Right H frontal ** Right H sensorimotor NS Right H parietal-occipital NS Right H temporal * *p.05, **p.01, NSNot significant SDSleep deprivation, HHemisphere p Table 3. LNNB factor scale scores before and after sleep deprivationsn18 Meanstandard deviation t-value p Before SD After SD Arithmetic calculation NS Number reading NS General verbal intelligence NS Simple verbal arithmetic NS Complex verbal arithmetic * *p.05, **p.01, NSNot significant SDSleep deprivation 2. 수면박탈을전후로한 LNNB 요약척도및국재화척도의비교 3. 수면박탈을전후로한요인척도의비교 고찰 328

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7 참고문헌 1) Durie DJ(1981):Sleep in animals. In Psychopharmacology of Sleep. Edited by D. Wheatley. New York, Raven Press 2) Carlson NR(1997):Sleep. In The Physiological Psychology. 4th ed. Boston, Allyn and Bacon, pp ) Wilkinson RT, Tyler PD, Varet CA(1975):Duty hours of young hospital doctors:effects on the quality of work. J Occu Psycho 48: ) Friedman RC, Bigger JT, Kornfeld DS(1971): The intern and sleep loss. N Engl J Med 285: ) Hart RP, Buchsbaum DG, Wade JB(1987):Effect of sleep deprivation on the first year residents response times, memory and mood. J Med Educ 62: ) Denisco RA, Drummond JN, Gravenstein JS (1987):The effects of fatigue on the performance of a simulated anesthetic monitering task. J Clin Monit 3: ) Bartle EJ, Sun JH, Thompson Ll(1988):The effects of acute sleep deprivation during residency training. Surgery 104: ) Orton DI, Gruzeller JH(1989):Adverse changes in mood and cognitive performance of house officers after night duty. Br Med J 298: ) Deaconson TF, O Hair DP, Levy INF(1988):Sleep deprivation and resident performance. JAMA 260: ) Storer JS, Floyd HH, Gill WL(1989):Effects of sleep deprivation on cognitive ability and skills of pediatrics residents. Acad Med 64: ) Reznick RK, Folse JR(1987):Effects of sleep deprivation on the performance of surgical residents. Am J Surg 154: ) Light AI, Sun JH, Thompson L(1989):The effect of acute sleep deprivation on level of resident training. Curr Surg 46: ) Golden CJ, Purisch AD, Hammeke TA(1978): Diagnostic validity of a standardized neuropsychological battery derived from Luria s neuropsychological tests. J Consul Clin Psycho, pp ) 염태호, 박영숙, 오경자, 김정규, 이영호 (1992): K-WAIS 실시요강. 한국가이던스 15) Wilkinson RT(1961):Interaction of lack of sleep with knowledge of results, repeated testing and individual differences. J Exp Psychol 62: ) Leung L, Baker CE(1992):Sleep deprivation and house staff performance. J Occu Med 34: ) Kaufman AS(1990):Assessing adolescent and adult intelligence. Boston, Allyn and Bacon 18) Wilkinson RT(1973):Sleep deprivation. In Edholm OG, Bacharach AL, eds. The Physiology of Human Survival. London, Academic Press, pp ) Luria AR(1973):The Working Brain:An introduction to neuropsychology. New York, Basic Books 20) 김명선편역 (1997):Luria AR 외. 신경심리의원리와평가. 하나의학사 21) Golden CJ, Purisch AD, Hammeke TA(1995): Luria-Nebraska Neuropsychological Battery Manual and Form. Western Psychological Services 331

8 ABSTRACT J Korean Neuropsychiatr Assoc Vol 38, No 2, March 1999 Effects of Total Sleep Deprivation on the Cognitive Function in the Normal Adult Male Subjects Heung pyo Lee, M.A., Dai-Jin Kim, M.D., Hyo Jin Go, M.D., Soo Yong Kim, Ph.D., Sung Phil Lee, M.D. Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul ObjectivesThis study was carried out to evaluate the effect of acute sleep deprivation of 36 hours on cognitive functions, and investigate which region of brain would dysfunction by sleep deprivation. MethodsWe carried out sleep deprivation in the 18 healthy and right handed males in their 20 s. We also administered to them Luria-Nebraska Neuropsychological Battery and Calculation and Digit Span task of K-WAIS in order to examine cognitive functions before and after sleep deprivations. ResultsThere were no differences in freedom from distractability, tactile function, visual function, reading, writing, calculation, and intellectual process function. However, motor function, rhythm, receptive speech, expressive speech, memory, and complex verbal arithmetic function decreased after sleep deprivation. In motor function, delayed speed and high fail rate in complex forms of praxis and selectivity of motor acts were observed. In area of receptive speech and expressive speech, understanding of logical and grammatical structure, spontaneous speech, sequencing and filling in items which are grammatically accurate decreased. All these functions related with dysfunction in right hemisphere anterior region. Also in localization scales, the fail rates of right frontal dysfunction scale and right temporal dysfunction scale increased after sleep deprivation. ConclusionsFrom these results, we suggest that sleep deprivation has negative effect on the cognitive functions. Especially, sleep deprivation might be associated with dysfunction of anterior region in right hemisphere or subcortical dysfunction. KEY WORDSSleep deprivation Cognitive function Luria-Nebraska Neuropsychological Battery. 332