OmniOx (HFT 500) Jan Prepared by MEKICS. OmniOx-HFT500 Jan ver1.1 1

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1 OmniOx (HFT 500) Jan Prepared by MEKICS OmniOx-HFT500 Jan ver1.1 1

2 0. Index 1. Introduce of OmniOx (HTF500) 2. Specification (HFT, CPAP+) 3. The World Best Features 2 OmniOx-HFT500 Jan ver1.1 2

3 1. What is High Flow Therapy s Definition? Flows that exceed patient demands at various minute volumes 2. How does HFT impact breathing? CO2 Ventilation Washout of the nasopharyngeal dead space Efficient Oxygenation Work of Breathing Reduction in inspiratory resistance associated with gas flow through the nasopharynx Energy Cost of Gas Conditioning Improvement in respiratory mechanical parameters associated with gas temperature and state of humidification Reduction in metabolic work associated with gas conditioning Provision of mild distending pressure OmniOx-HFT500 Jan ver

4 3. Must reduce the dead space of Upper Airway (the nasal cavity) Circulation and Maintain of fresh air (minimized dead space) Appropriated PEEP (airway security) Minimized resistance of exhalation (efficiency of CO2 deflation and optimized positive pressure) The best solution is JET FLOW EFFECT OmniOx-HFT500 Jan ver1.1 4

5 4. CO2 Ventilation Washout of nasopharyngeal dead space Improved fractions of alveolar gases with respect to carbon dioxide Low flow nasal cannula therapy is only thought to facilitate oxygenation HFT impacts CO2 elimination Flushing of dead space in the Nasopharyngeal cavity helps Enhance alveolar ventilation OmniOx-HFT500 Jan ver1.1 5

6 5. Efficient Oxygenation High inspired oxygen fractions by eliminating room air entrainment during inspiration Improve alveolar oxygen fractions beyond mask therapy based on the equation for alveolar ventilation Patients can often maintain better oxygenation or require a lower FiO2 compared to conventional mask or cannula therapies OmniOx-HFT500 Jan ver1.1 6

7 6. Work of Breathing(WOB) HFT provides enough flow to match or exceed a patient s inspiratory flow HFT most likely minimizes the inspiratory resistance associated with the nasopharynx Adequate warming and humidification of the conducting airways by delivery of warm, humid gas is associated with improved conductance and pulmonary compliance compared to dry, cooler gas Delivery of breathing gases at body temperature and saturation promotes an ideal respiratory mechanical response OmniOx-HFT500 Jan ver1.1 7

8 7. Energy Cost of Gas Conditioning The nasal air passages expend energy to warm inspiratory air from ambient to 37 and vaporize water to humidify the incoming air to 100% relative humidity Alleviated when gas is delivered at body temperature and saturated OmniOx-HFT500 Jan ver1.1 8

9 8. ACPAP+? Unique technology for the first time by MEKICS in the World New concept of positive pressure support for easy exhalation that support inspiration in inhalation of breath and interrupt the flow quickly in exhalation Same effect but more comfortable to inhale and exhale both together so it is basically big different with CPAP. Clinical effect of comfortable breathing Most of case of CPAP patient needs to have adaptation period due to uncomfortable Increase of WOB, and disturb of stable sleeping Clinical effect beside the ventilation only. 9 OmniOx-HFT500 Jan ver1.1 9

10 ACPAP+ (Adaptive CPAP & PSV) Positive Pressure Support, Lower expiration resistance as support of inspiration Maintain of airway and comfortable breathing ACPAP s Pressure Flow Pressure PSV Trigger Flow -Machine Flow -Patient Ex. time Easy to breathing? = Possible to support of inspiration and low of expiration resistance Support of Inspiration: PSV Trg Expiration Resistance : Ex_Sen, ExTime 10 OmniOx-HFT500 Jan ver1.1 10

11 HFT500 Target Market HFT500 HFT OmniOx-HFT500 Jan ver1.1 11

12 2. Specification Functions General 4.3 Color TFT, Touch Screen, Knob Mode : HF/CPAP, PS/CPAP O2 Mixer FiO2, Respiration, SpO2 Monitoring Built in Humidifier HF/CPAP : Flow(Lpm), O2(%) PS/CPAP : PSV, PAP, Trigger, ExTime, Ex_Sense, O2(%), Wake-up Performance Pressure : Up to 100cmH2O Flow : Up to 160 Lpm / 60 Lpm (HFT) O2 : 21 ~ 100% 12 OmniOx-HFT500 Jan ver1.1 12

13 3. The World Best Features (HF/CPAP) Jet Flow Nasal Cannula MEKICS Competitors Flow /Pressure Drive Power Effect 10~ 60 lpm Up to 100cmH2O Available Jet Flow Low Expiratory Resistance 10 ~ 40 lpm(60lpm) Up to 40cmH2O Not Jet-Flow High Expiratory Resistance 13 OmniOx-HFT500 Jan ver1.1 13

14 3. The World Best Features (PS/CPAP) ACPAP+ PSV at Ins. Phase Quick Pause in Exp. Phase Pressure PSV, Easy Expiration Quick Pause Pressure No PSV, Expiratory Effort Trigger Flow -Machine Flow -Machine Flow -Patient Flow -Patient Ex. time <MEKICS> <Competitors > OmniOx-HFT500 Jan ver

15 References 1. Finer NN, Bates R, Tomat P. Low flow oxygen delivery via nasal cannula to neonates. Pediatr Pulmonol 1996;21(1): Sreenan C, Lemke RP, Hudson-Mason A, Osiovich H. High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure. Pediatrics 2001;107(5): Waugh JB, Granger WM. An evaluation of 2 new devices for nasal high-flow gas therapy. Respir Care 2004;49(8): Negus VE. Humidification of the air passages. Thorax 1952;7(2): Williams R, Rankin N, Smith T, Galler D, Seakins P. Relationship between the humidity and temperature of inspired gas and the function of the airway mucosa. Crit Care Med 1996;24(11): Kelly MG, McGarvey LP, Heaney LG, Elborn JS. Nasal septal perforation and oxygen cannulae. Hosp Med 2001;62(4): Robertson NJ, McCarthy LS, Hamilton PA, Moss AL. Nasal deformities resulting from flow driver continuous positive airway pressure. Arch Dis Child Fetal Neonatal Ed 1996;75(3):F Loftus BC, Ahn J, Haddad J, Jr. Neonatal nasal deformities secondary to nasal continuous positive airway pressure. Laryngoscope 1994;104(8 Pt 1): Kopelman AE, Holbert D. Use of oxygen cannulas in extremely low birthweight infants is associated with mucosal trauma and bleeding, and possibly with coagulase-negative staphylococcal sepsis. J Perinatol 2003;23(2): Campbell EJ, Baker MD, Crites-Silver P. Subjective effects of humidification of oxygen for delivery by nasal cannula. A prospective study. Chest 1988;93(2): Rankin N. What is optimum humidity? Respir Care Clin N Am 1998;4(2): Williams RB. The effects of excessive humidity. Respir Care Clin N Am 1998;4(2): Woodhead DD, Lambert DK, Clark JM, Christensen RD. Comparing two methods of delivering high-flow gas therapy by nasal cannula following endotracheal extubation: a prospective, randomized, masked, crossover trial. J Perinatol 2006;26(8): Dewan NA, Bell CW. Effect of low flow and high flow oxygen delivery on exercise tolerance and sensation of dyspnea. A study comparing the transtracheal catheter and nasal prongs. Chest 1994;105(4): OmniOx-HFT500 Jan ver1.1 15

16 References 15. Shepard JW, Jr., Burger CD. Nasal and oral flow-volume loops in normal subjects and patients with obstructive sleep apnea. Am Rev Respir Dis 1990;142(6 Pt 1): Greenspan JS, Wolfson MR, Shaffer TH. Airway responsiveness to low inspired gas temperature in preterm neonates. J Pediatr 1991;118(3): Fontanari P, Burnet H, Zattara-Hartmann MC, Jammes Y. Changes in airway resistance induced by nasal inhalation of cold dry, dry, or moist air in normal individuals. J Appl Physiol 1996;81(4): Fontanari P, Zattara-Hartmann MC, Burnet H, Jammes Y. Nasal eupnoeic inhalation of cold, dry air increases airway resistance in asthmatic patients. Eur Respir J 1997;10(10): Proctor DF. Physiology of the upper airway. In: Visher MB, Hastings AB, Pappenhiemer JR, Rahn H, editors. Handbook of Physiology-Respiration 1. Baltimore: Williams & Wilkins; p Mlynski G. Physiology and pathophysiology of nasal breathing. In: Behrbohm H, Tardy T, editors. Essentials of Septorhinoplasty: Philosophy-Approaches-Techniques. Stuttgard, NY: Thieme Medical Publishers; p Locke RG, Wolfson MR, Shaffer TH, Rubenstein SD, Greenspan JS. Inadvertent administration of positive end-distending pressure during nasal cannula flow. Pediatrics 1993;91(1): Kahn DJ, Courtney SE, Steele AM, Habib RH. Unpredictability of Delivered Bubble Nasal Continuous Positive Airway Pressure Role of Bias Flow Magnitude and Nares-Prong Air Leaks. Pediatr Res Kubicka ZJ, Limauro J, Darnall RA. Heated, humidified high-flow nasal cannula therapy: yet another way to deliver continuous positive airway pressure? Pediatrics 2008;121(1): Wilkinson DJ, Andersen CC, Smith K, Holberton J. Pharyngeal pressure with high-flow nasal cannulae in premature infants. J Perinatol 2008;28(1): Saslow JG, Aghai ZH, Nakhla TA, Hart JJ, Lawrysh R, Stahl GE, Pyon KH. Work of breathing using high-flow nasal cannula in preterm infants. J Perinatol 2006;26(8): Pyon KH, Aghai ZH, Nakhla TA, Stahl GE, Saslow JG. High Flow Nasal Cannula in Preterm Infants: Effects of High Flow Rates on Work of Breathing. PAS 2008;63: Spence KL, Murphy D, Kilian C, McGonigle R, Kilani RA. High-flow nasal cannula as a device to provide continuous positive airway pressure in infants. J Perinatol 2007;27(12): OmniOx-HFT500 Jan ver1.1 16

17 END Thanks for your attention 17 OmniOx-HFT500 Jan ver1.1 17