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2 Drugs, Driving

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4 Contents Contents V Dedication... IX Credits and acknowledgements... XI List of contributors... XIII Preface... XIX... 1 Henry J. Moller Worldwide trends in alcohol and drug impaired driving Barry M. Sweedler and Kathryn Stewart Drugs, driving, and models to measure driving impairment Katherine Owens and Johannes G. Ramaekers Measurement and methods to determine driving ab Günter Berghaus and Ralf-Dieter Hilgers Simulator studies of drug-induced driving impairment Anthony Liguori The on-the-road driving test Joris C. Verster and Johannes G. Ramaekers Olaf H. Drummer Case-control studies Sjoerd Houwing, René Mathijssen and Karel A. Brookhuis Prescribing and dispensing guidelines for medicinal drugs affecting driving performance Johan J. de Gier, F. Javier Alvarez, Charles Mercier-Guyon and Alain G. Verstraete

5 VI Contents The relationship between drug use a Beitske E. Smink and Toine C. G. Egberts of drugs abused in driving Marilyn A. Huestis and Michael L. Smith a review of the epidemiological evidence Jennie L. Connor Sleepiness, countermeasures and the risk of motor vehicle accidents Christopher A. Alford Joris C. Verster, Monique A.J., Mets, Tim R.M. Leufkens and Annemiek Vermeeren Mark E. Howard, Melinda L. Jackson and Stuart Baulk Monique A. J. Mets, Kenny R. van Deventer, Berend Olivier, Edmund R. Volkerts and Joris C. Verster Annemiek Vermeeren, Tim R.M. Leufkens and Joris C. Verster Joris C. Verster and Johannes G. Ramaekers and d Daniel J. Cox and Margaret Taylor Davis in Parkinson s disease Yvonne Kaussner and Hans-Peter Krüger Sylvia Kotterba and chronic pain Dieuwke S. Veldhuijzen, Anne Mieke Karsch and Albert J.M. van Wijck Eef Lien Theunissen, Annemiek Vermeeren, Eric F. P. M. Vuurman and Johannes G. Ramaekers

6 Contents VII Igor A. Harsch and Katharina Hoesl Changes in and predictors of driving after drug use and involvement crashes because of drugs, Ralph W. Hingson and Wenxing Zha 415 James C. Fell and Robert B. Voas Interventions to reduce impaired driving David A. Sleet, Peter Howat, Randy Elder, Bruce Maycock, Grant Baldwin and Ruth Shults The alcohol ignition interlock and other technologies for the prediction and control of impaired drivers Paul R. Marques Dose related risk of motor vehicle crashes after c Johannes G. Ramaekers, Günter Berghaus, Margriet W. van Laar and Olaf H. Drummer Kim P.C. Kuypers, Wendy M. Bosker and Johannes G. Ramaekers Appendix I ICADTS Drug List Appendix II Guidelines on experimental studies undertaken to determine a medicinal drug s effect on driving or skills related to driving

7 Credits and acknowledgements Dedication IX To our friends and families

8 Credits and acknowledgements Credits and acknowledgements XI this new volume entitled This book gives a comprehensive overview of the effects of common diseases and their treatments on lot of help from several people. We were fortunate to experience professional and enthusiastic support from Ms Beatrice Menz and Kerstin Tuechert, editors at Birkhauser Verlag. Their commitment to excellence was a strong guiding force throughout the development of this volume. We also want to thank all authors for spending their precious time on contributing a chapter. and support. Joris C. Verster S.R. Pandi-Perumal Johannes G. Ramaekers Johan J. de Gier

9 List of contributors List of contributors XIII Christopher A. Alford F. Javier Alvarez Grant Baldwin Stuart Baulk Günter Berghaus Maastricht, The Netherlands Karel A. Brookhuis - Jennie L. Connor Department of Preventive and Social Medicine, Dunedin School of Medicine, Daniel J. Cox Victorian Institute of Forensic Medicine, Department of Forensic Medicine,

10 XIV List of contributors Toine C.G. Egberts James C. Fell Johan J. de Gier Care, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands Alcohol Abuse and Alcoholism, 5635 Fishers Lane, Room 2077, Bethesda, MD - dam, The Netherlands - Melinda L. Jackson

11 List of contributors XV Anne Mieke Karsch - - Yvonne Kaussner - Margriet W. van Laar erlands Tim R.M. Leufkens - Paul R. Marques dam, The Netherlands Monique A.J. Mets

12 XVI List of contributors - Melbourne, Australia Seithikurippu R. Pandi-Perumal Johannes G. Ramaekers Maastricht, The Netherlands Ruth Shults David A. Sleet Beitske E. Smink Michael L. Smith - - Eef L. Theunissen Maastricht, The Netherlands - -

13 List of contributors XVII Annemiek Vermeeren - Joris C. Verster Alain G. Verstraete - Ghent, Belgium Robert B. Voas Edmund R. Volkerts Eric F.P.M. Vuurman Maastricht, The Netherlands - - Alcohol Abuse and Alcoholism, 5635 Fishers Lane, Room 2077, Bethesda, MD

14 Preface Preface XIX The volume covers the impact of various diseases nal drugs among drivers is estimated between 5 and 35 %. The chapters of alcohol and drug impaired driving. Thereafter, nine chapters describe the various - ters discuss the most common diseases and their treatments on driving performance section of drugs that have been investigated on possible effects on driving and their corre- experimental studies undertaken to determine a medicinal drug s effect on driving The volume will be an important reference book who want to drive a car. Although not all medical conditions, treatments and illicit

15 XX Preface, the volume is a useful overview of the current state of knowledge on drugs and driving. It is our hope that we have succeeded in producing a useful book. As usual, we welcome communications from our readers concerning our volume. Joris C. Verster S.R. Pandi-Perumal Johannes G. Ramaekers Johan J. de Gier