DAILY NEWS BULLETIN LEADING HEALTH, POPULATION AND FAMILY WELFARE STORIES OF THE Day Thursday

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1 DAILY NEWS BULLETIN LEADING HEALTH, POPULATION AND FAMILY WELFARE STORIES OF THE Day Thursday Health What Does Your Morning Face Say about Your Health? (The Economic Times: ) Morning-Face-Say-about-Your The image you see when you look in the mirror while brushing your teeth in the morning can reveal how well you slept the previous night, how stressed you are or, more importantly, how good is your health, reports Hansa Venkateswaran You may not look the same whenyou wake up every morning. On some days, there's an enviable glow on your face, on some you are just okay and on other days, you look completely sapped of energy as if you battled a storm the previous night. You may brush off these different looks as something routine, but they can reveal a lot about your inner health. Some may indicate common ailments while others can point to something more serious for you to act upon. Since the skin is the largest organ of the body, it clearly reflects what goes on inside your body and what the status of your health is, said Dr Neha Mittal, cosmetic physician at Dermaworld Skin & Hair Clinics, Delhi. There are various signs and symptoms that your body starts exhibiting that depict that something is not normal... One should be aware of these sudden changes in the skin, which are quite noticeable early in the morning. Here are some ailments you can read from your wake-up face: THE LOOK: TIRED What it may mean: A. LACK OF SLEEP

2 Sleep is a natural reset button for our brain and body, which is even more required these days because of increased work pressure and stress. Face is the index of the mind... a skipped sleep is easily identified on the face, said Dr Jaidev Yadav, consultant dermatologist at Vikram Hospital, Bengaluru. B. DEPRESSION Along with tiredness, depression can appear as skin lesions too. A trained dermatologist can recognise this symptom and guide the patient to a psychiatrist for treatment. A major reason for skin eruptions is alcohol and drug abuse, said Yadav. Other symptoms include vertigo and insomnia. THE LOOK: DRY FLAKY AND DULL SKIN ALONG WITH CHAPPED LIPS What it may mean: Dehydration Lack of adequate intake of water is the prime reason for dehydration, said Mittal.The person can also suffer from increased thirst, headache, dizziness, dry mouth and a feeling of cold at times. THE LOOK: DISCOLOURED UNDER-EYE What it may mean: Anaemia Improper eating habits are the main reason for this. Moving away from traditional eating to western foods and the eating-out culture are causing nutritional imbalance.for example, taking lesser green leafy vegetables, dates and ragi that provide the required iron has led to a drop in daily consumption. Eating fried foods has reduced the protein intake in the diet. Lack of enough lentils (dal) and vegetables has led to reduced vitamin B intake, said Dr Dharini Krishnan, a consultant dietitian based in Chennai. Those suffering from anaemia may experience hair loss and weakness too. Women are more prone to this condition. THE LOOK: PUFFY FACE What it may mean:cold andor sinusitis It is usually accompanied by a stuffy nose and a heavy head. While the common cold is caused by a virus, stuffy nose, specially if it isn't running, could be because of dust allergy, improper ventilation and clogged air-conditioning filters. Unclean carpets and upholstery of the furniture also cause a cold due to the dust, explained Krishnan. There can also be external sources causing the puffy face, according to Yadav. Infections from bacteria, fungi or viruses bear a direct correlation to the immunity of an individual and are seen as a puffy face, he said. THE LOOK: YELLOW SPOTS ON EYELIDS a What it may mean: Heart diseases The yellow spots on the eyelids are choles terol-filled lesions, called xanthelasmata.

3 They are a warning sign that the person is at a higher risk for heart diseases. However, it is not wise to wait for a heart disease symptom to show up on the skin. Adopt a heart-healthy lifestyle, know about other d symptoms of heart trouble and visit your doctor if you experience any of those.s THE LOOK: ACNE What it may mean: Hormonal imbal ance Hormonal triggers lead to an oily face and, thereby, acne. If accompanied by unwant ed facial hair, irregular periods and weight e gain, it may be an indication of polycystic. ovarian syndrome in women. Braind related ailments are known to show up as d acne, especially among teens and tweens. For a Glowing Wake-up Face, Make Yourself Healthy from Inside A healthy and smiling face can be the simplest way to tell if a person's inner health is fine, which is clearly reflected on the skin. In Ayurveda, this concept is called Sara Pariksha (examination of the health of the tissues). The primary factor that influences this is the diet the person consumes and the lifestyle the person follows, said Dr Madhumitha Krishnan, Ayurvedic physician at Aster CMI Hospital, Bengaluru. When a person is healthy, the agni (digestive fire) is proper, which indicates that the food consumed is properly and adequately converted into the various physiological factors that make up the human body. In turn, when all these physiological factors work in harmony, the mental status of the person is good and a person glows with health, she said. Since the face depicts the inner health, the solution is to consume healthy, nutritious foods rich in vitamins, minerals and fibres, so that the body is healthy from within, said Mittal from Dermaworld. One must also follow a skincare routine based on hisher skin type, which should include cleaning, toning and moisturising, she added. Include exercise in your routine. Start with brisk walking and top it with easy exercise for a fit body.exercising improves blood circulation and makes your body flexible, she said, adding, Limit the amount of alcohol and caffeinated drinks. In short, adopt a healthy lifestyle and wake up to see a healthy you.

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5 HEALTH CAPSULE We bring you the latest from the world of medicine and wellness (The Economic Times: ) CAPSULE Heart Attacks are more Likely in Winters Heart attacks are more prevalent in the winter season, as lower tempera tures act as an external trigger for the life threatening condition, a study claims. Research ers at Lund University in Sweden found that there was a higher occurrence of heart attacks in sub-zero temperatures. When the daily temperature was less than zero degree Celsius, the average rate of heart attacks a day peaked to four, compared to when it was above 10 degrees, researchers said.furthermore, occurrence of heart attacks increased with higher wind velocities, limited sunshine duration and higher air humidity. The findings were the same across a large range of patient subgroups, and at national as well as regional levels, suggesting that air temperature is a trigger for heart attack.the body responds to cold by constricting superficial blood vessels, which decreases thermal conduction in the skin and subsequently increases arterial blood pressure, researchers said. Other responses are shivering and increased heart rate, which raise the metabolic rate and in turn increase body temperature, they added. There is seasonal variation in the occurrence of heart attack, with incidence declining in summer and peaking in winter, Moman A Mohammad from the department of cardiology at Lund University. Exercising may Help You Remember more

6 Exercising just after learning something new may help students -especially girls -retain the information they learn in school, a study has found. In four experiments, 265 participants performed either five minutes of low-impact step aerobics after learning, or no exercise after learning. Although the strength of the effect varied between experiments, researchers found that women who did step exercise after learning remembered the material better than those who did not do the exercise. The findings, published in the journal 'Cognitive Research: Principles and Implications', add to accumulating evidence that bouts of exercise after study can lead to measurable improvements in memory. The effect came into play only after participants had studied the material, meaning that it retroactively boosted learning of the material, said Steven Most from University of New South Wales in Australia. But mysteriously, this effect did not emerge among men in any of the experiments, said Most. It is unclear whether this is a true sex difference or whether there was something about the experiment conditions that allowed the effect to emerge among women and not men, he said. Drug Cuts Risk of Cancer, Heart Attack A class of drugs used to re duce inflammation can lower the risk of recurrent heart attacks, strokes and lung cancer, a study claims. The drug canakinumab can cut expensive interventions, such as bypass surgery, by more than 30%, researchers said. In a trial lasting 25 years, scientists from the Brigham and Women's Hospital in the US tested whether reducing inflammation among people who have had a prior heart attack can reduce risk of another cardiovascular event in the future. They enrolled over 10,000 patients who previously had a heart attack and had persistent, elevated levels of high sensitivity C-reactive protein (hscrp), a marker of inflammation. All patients in the trial received aggressive standard care, which included high doses of cholesterol-lowering statins. In addition, participants were randomised to receive 50, 150, or 300 mg of canakinumab (or a placebo for the control group), injected once every three months. Patients were followed for up to four years.

7 Nose Allergy ET By IvInvite - Knowing the Allergen is a Key Step in Avoiding Nose Allergy (The Economic Times: ) Knowing-the-Allergen-is-a Diagnosing allergic rhinitis is usually very straight forward based on the symp toms experienced by the patients Allergic rhinitis is a group of symptoms affecting the nose. These symptoms occur when you breathe in something you are allergic to, such as dust, animal dander or pollen. Allergic rhinitis is of two types: seasonal (allergic symptoms experienced only during a particular time period of the year when allergens such as pollen etc. are high in atmosphere) and perennial (when allergic symptoms are present throughout the year). CAUSES OF NASAL ALLERGY When our body comes in contact with an allergen (a substance which produces allergic reaction), a chemical called histamine, among many other chemicals, is produced. This chemical is primarily responsible for producing allergic symptoms. Genetic predisposition (hereditary) plays an important part.chances of children developing allergy if one or both parents suffer from allergies are 20% and 47%, respectively. SYMPTOMS OF NASAL ALLERGY

8 Symptoms that occur shortly af ter you come into contact with the substance you are allergic to may include: Itchy nose, mouth, eyes, throat, skin or any other area Runny nose and watering eyes Sneezing Symptoms that may develop later include: Stuffy nose (nasal congestion) Clogged ears and decreased sense of smell Sore throat Dark circles under the eyes Puffiness under the eyes Headache DIAGNOSING ALLERGIC RHINITIS Diagnosing allergic rhinitis is usually very straightforward based on the symptoms experienced by the patients.diagnosing specific allergens to which the patient is allergic to is the first step for successfully treating allergies. While a few patients clearly indicate how their symptoms start immediately after exposing themselves to certain environments (such as dust) or after consuming certain foods or drinks, some have no clue as to what causes these allergic symptoms. For either of the cases, we now have the highly-specific Allergic Skin prick test to diagnose what the patients are allergic to. The Allergic Skin prick test is a painless procedure where the skin is pricked with a needle containing a small amount of the allergen that attempts to provoke a small, controlled, allergic response (a very small patch of raised skin) at the site of prick. The blood tests (specific IgE measurements) available are somewhat less sensitive when performed alone for diagnosing. TREATING ALLERGIC RHINITIS The most important method of treating allergic rhinitis is the identification and complete avoidance of exposure to allergens. When allergen exposure cannot be avoided, oral antihistamines, oral and topical steroid sprays produce good control of most of the symptoms.immunotherapy is one of the recent treatment advancements available with us providing near total cure of allergic rhinitis. Mosquito-borne diseases, Workers who check mosquito breeding face insults, hazards (The Times of India: ) All three corporations are short of DBC staff; technological interventions to help them failed Domestic breeding checkers, Delhi s first line of defence against the spread of mosquitoborne diseases, ended their strike on Wednesday. Around 3,500 workers, who go from one house to another to ensure mosquito breeding is not taking place on the premises, had been demanding regular jobs.

9 The checkers work under the municipal corporations and brave several problems every day when they go from house to house to ensure that conditions conducive to mosquito breeding are not there. They also make people aware about not allowing mosquito breeding in their premises. Hasib Ahmed, a DBC in Tughlakabad Extension, gets a target of 50 houses every day. He spends at least 15 minutes to check breeding in one house. But despite best efforts, he manages to inspect only 30 homes. He has to check desert coolers, flower pots, put medicine stagnant water, check water tanks on the terrace and then make appropriate entries in his tablet or register. Meeting the target is impossible, if we properly check each house, Ahmed said. Since the number of checkers is far less than required to cover a city as big as Delhi, it takes at least 40 days for a breeding checker to visit a house again. It is enough time for mosquitoes to start breeding again as the breeding cycle of mosquitoes is one week and the effect of temefos granules that are used to kill mosquito larva in stagnant water is effective for just two weeks. According report by South Delhi Municipal Corporation, which is the nodal agency for collating data of mosquito-borne diseases, the south body alone needs 35,000 DBC workers, if the houses in its jurisdiction are to be inspected every week or at least in 10 days. SHORT OF HANDS Not just DBC workers, around 80% posts designated for staff to keep a check on mosquito breeding sites are vacant for more than two years. At least 108 of the sanctioned 129 posts of malaria inspectors in North Corporation are vacant. Similarly, 55 of 65 post in the east civic body and 72 of 104 in south corporation have not been filled for years. Six posts of antimalaria officers and 15 of senior malaria inspectors in the north body have not been filled. In East civic body all posts antimalaria officers are vacant. DAILY HAZARDS Most DBCs say that over 50% of the houses they visit do not allow them entry. Sunil, a DBC in Mehrauli, said, The people abuse us and say we want to threaten them to extort money from them. The corporations issued identity cards and uniforms to field workers but that hasn t helped either. Most gated colonies restrict entry for visitors, he said. President of Anti Malaria Union of Workers Budhram said, We should have the power to issue challans. We are at the receiving end always. TABLET BURDEN The south corporation recently issued tablets to its 200 DBCs. It has an application to mark every household visited by the checkers. The workers, however, say it has slowed them down.

10 In less than 6 months, 30 tablets were returned. We have to carry both a register and tablet because when there is a network issue we have to make entries in the register, said Madan Lal, secretary of Anti Malaria Workers Union. Healthcare Why patient-centric care is non-existent in India (The Times of India: ) The refusal to consider the outcomes for people as a parameter to judge the quality of healthcare is baffling Every time there is a serious crisis in a State run health facility, there is always a lot of discussion on how India is not spending enough on the sector. But this conversation does not focus on one critical aspect that needs to be fixed: The importance of patient-centric healthcare. DEEPAK GUPTA/HT n A child being looked after by medical staff at the Encephalitis ward of the BRD medical centre, Gorakhpur, August 13 At present, the country s healthcare system is geared towards the needs of hospital managements and pharmaceutical companies. There is hardly any concern about doctors and other healthcare providers, and more importantly on curing a patient. Surprisingly, even patients do not take the cure as an important matter till they have a bad experience. What do we mean by patient-centric systems? These are indicators that tell us whether patients are getting better. These standardised parameters are based on the premise that no matter how much money is spent per patient, the chances of the person getting better will still remain low if certain basic things are not taken care of. For example, do hospital Operation Theatres have elbow-operated taps? Are there separate places for keeping medicines with similar-sounding names? Are the equipment serviced and calibrated regularly? Do caregivers maintain the basics of hygiene and wash their hands? It is only when these things are followed scrupulously, the per patient expenditure made by the State becomes important. How does one ensure the creation and existence of a patient-centric system? The only way to do so is by following protocols, by maintaining data within the patient care facility along all

11 parameters of the protocol and reviewing them constantly. In India, these protocols are not followed because there is no law that compels the healthcare facilities to keep track of such data or to learn from it. Those few that do, report improvements in their abilities to cure patients. In the absence of laws, only expenditure-income data is maintained and the effort to create positive results revolves only around this data. It will be too naive to focus only on the amount of money spent and the numbers of patients treated. So, why is there such persistent refusal to consider patient outcomes as an important parameter to judge the quality of health care? Is it possible that there is a fear that this would expose systemwide deficiencies? Is there a fear of discovering that even the five-star facilities that charge millions are no different in quality of care than the free-for-all public facility? Meeta Rajivlochan is an IAS officer. M Rajivlochan is director, internal quality assurance cell, Panjab Low-fat, high carb diet Low-fat, high carb diet may increase death risk: Study (Business Line: )

12 Consuming a diet low in fats and high in carbohydrates may increase the risk of early death, according to a major global study that contradicts dietary advice handed out for decades. The findings, published in The Lancet journal, may explain why certain populations such as South Asians, who do not consume much fat but eat a lot of carbohydrates, have higher mortality rates, researchers said. The study on more than 1,35,000 people across five continents found that a diet which includes a moderate intake of fat and fruits and vegetables, and avoidance of high carbohydrates, is associated with lower risk of death. The lowest risk of death was in those people who consume three to four servings (or a total of 375 to 500 grammes) of fruits, vegetables and legumes a day, researchers said. The researchers from McMaster University and Hamilton Health Sciences in Canada asked people about their diet and followed them for an average of seven and half years. The study on dietary fats found that they are not associated with major cardiovascular disease, but higher fat consumption was associated with lower mortality. This was seen for all major types of fats (saturated fats, polyunsaturated fats and mono unsaturated fats), with saturated fats being associated with lower stroke risk. Total fat and individual types of fat were not associated with risk of heart attacks or death due to cardiovascular disease, researchers said, adding, While the finding may appear surprising to some, they are consistent with several observational studies and randomised controlled trials conducted in Western countries during the last two decades. The study questions the conventional beliefs about dietary fats and clinical outcomes, said Mahshid Dehghan, the lead author for the study. A decrease in fat intake automatically led to an increase in carbohydrate consumption and our findings may explain why certain populations such as South Asians, who do not consume much fat but consume a lot of carbohydrates, have higher mortality rates, she said. Dehghan noted that dietary guidelines have focused for decades on reducing total fat to below 30 per cent of daily caloric intake and saturated fat to below 10 per cent of caloric intake.

13 This is based on the idea that reducing saturated fat should reduce the risk of cardiovascular disease, but did not take into account how saturated fat is replaced in the diet, she said. She added that the current guidelines were developed about four decades ago using data from some Western countries where fat was more than 40 per cent or 45 per cent of caloric intake and saturated fat intakes were more than 20 per cent. (This article was published on August 30, 2017) Gene therapy for cancer U.S. approves first gene therapy for cancer (The Hindu: )

14 Studies showed that 83% of patients responded to treatment The United States approved the first gene therapy in the nation on Wednesday a treatment that uses a patient s own immune cells to fight childhood leukaemia. The treatment is made by Novartis and is called Kymriah (tisagenlecleucel). This type of immunotherapy, known as a CAR-T cell therapy, was known by the term CTL019 until now. It was approved by the U.S. Food and Drug Administration for children and young adult patients up to age 25 with a form of acute lymphoblastic leukaemia. Historic action The FDA described the approval as a historic action that would usher in a new approach to the treatment of cancer and other serious and life-threatening diseases, said a statement. Studies have shown that 83% of patients responded to the treatment, achieving remission within three months. The treatment is not a pill or a form of chemotherapy. It uses a patient s own immune cells, called T-cells, along with white blood cells. These cells are removed from a patient, sent to a lab, and encoded with a viral vector, reprogrammed, and returned to the patient. Fat, carbs, fruit, veg Fat, carbs, fruit, veg: How much should we eat for health?( Medical News Today: )

15 Two complementary papers based on a large cohort study show that fats - both saturated and unsaturated - may not be as harmful as previously thought. Carbohydrates can have a more damaging impact, but should still be consumed in moderation, and a stable intake of fruits and vegetables is a must. A large cohort study, the Prospective Urban Rural Epidemiology (PURE) study, at the Population Health Research Institute of McMaster University in Canada, has paved the way for a better understanding of what makes healthful, balanced diets. The study collected data from 135,335 people with ages between 35 and 70, from 18 different countries across five continents, covering regions from the Middle East, South America, Africa, China, North America, Europe, and South Asia. Participants were asked to provide details about their socioeconomic situation, lifestyle, medical history, weight, and blood pressure, among others. They were followed up for a median period of 7.4 years, and relevant information regarding cardiovascular disease and death risk was collected periodically. PURE data was recently used in two complementary studies, one looking at the effects of macronutrients, especially fats and carbohydrates, on people's health and life expectancy, and the other exploring the global importance of fruit and vegetable intake. The first study, whose principal author is Dr. Mahshid Dehghan, from McMaster University, shows that diets that include a moderate fat intake and which avoid a high intake of carbohydrates are linked with a reduced risk of mortality. An article detailing the findings was published yesterday in The Lancet. Moderate fat intake is beneficial For the purpose of this study, data on the participants' daily dietary choices and habits were analyzed alongside other relevant information, to allow the researchers to calculate how much energy was provided by fat, carbohydrate, and protein intake in each individual's case. A surprising finding, which appears to contradict existing beliefs about healthy dietary practices, was that a higher total fat intake - providing 35.3 percent of energy - was linked with a 23 percent lower risk of mortality than a lower fat consumption. At the same time, a high intake of carbohydrates - providing 77 percent of energy - was found to correlate with a 28 percent higher mortality risk. How do vegetarian diets affect cholesterol levels? How do vegetarian diets affect cholesterol levels? Learn why vegetarian diets have a positive impact on health. READ NOW

16 Total fat intake was not significantly associated with a risk of mortality linked with cardiovascular disease, and carbohydrate intake was not associated with cardiovascular disease at all. These findings also have country-specific and cultural-specific implications, and may be related to the income level of each country, the researchers say. "A decrease in fat intake automatically led to an increase in carbohydrate consumption and our findings may explain why certain populations such as South Asians, who do not consume much fat but consume a lot of carbohydrates, have higher mortality rates," suggests Dr. Dehghan. Three to four a day A second paper also published yesterday in The Lancet, whose main author is Victoria Miller, a doctoral student from McMaster University, complements the other article's findings by looking at the importance of fruits, vegetables, and legumes to the diet. Based on relevant PURE data, Miller and her colleagues calculated how many servings of fruits, vegetables, and legumes the participants consumed on a regular basis. The researchers defined "one serving" as 125 grams of fruits or vegetables, or 150 grams of cooked legumes, in accordance with recommendations from the United States Department of Agriculture. Potatoes, other tuberous crops, legumes, and fruit and veg juices were not included as vegetables. The study took "legumes" to refer to beans, black beans, lentils, peas, chickpeas, and black-eyed peas. The researchers found that three to four servings of fruits and vegetables per day correlated with the best health outcomes. "Our study found the lowest risk of death in those who consumed three to four servings or the equivalent to 375 to 500 grams of fruits, vegetables and legumes per day, with little additional benefit for intake beyond that range. Additionally, fruit intake was more strongly associated with benefit than vegetables." Victoria Miller Country-specific considerations Miller and her team also noted that, on a global level, fruit, vegetable, and legume intake is of three to four servings per day, despite the fact that many state dietary guidelines recommend a "five-a-day" regime. The researchers suggest, however, that eating five servings of fruits and vegetables per day may be unattainable in many middle- and low-income countries, where these foods are

17 expensive for the general population. This appears to be the case in regions such as South Asia, China, Southeast Asia, and Africa. The fact that the study was conducted with participants from across five continents, the researchers argue, gives extra credibility to research, showing that plant-based diets are more healthful. "The PURE study includes populations from geographic regions which have not been studied before, and the diversity of populations adds considerable strength that these foods reduce disease risk," says Miller. Another important finding of Miller and her team's study was that raw vegetables are more healthful than cooked ones, a distinction which is not usually made in dietary guidelines across the world. This "raw" versus "cooked" debate also taps into country-specific dietary practices, the researchers say. "Raw vegetable intake was more strongly associated with a lower risk of death compared to cooked vegetable intake, but raw vegetables are rarely eaten in South Asia, Africa and Southeast Asia. Dietary guidelines do not differentiate between the benefits of raw versus cooked vegetables - our results indicate that recommendations should emphasize raw vegetable intake over cooked," explains Miller. The findings of the two related studies add some important considerations regarding the effects of different diets on health outcomes, especially as they outline the global framework of dietary practices. The researchers also presented the results of their studies yesterday, at the specialist Congress of the European Society of Cardiology in Barcelona, Spain. Obesity Obesity: Lack of 'satiety hormones' plays a role?( Medical News Today: ) A new study provides further evidence that metabolic factors have a part to play in obesity, after finding that people who are obese release significantly fewer "satiety hormones" after eating, compared with lean individuals. In the United States, it is estimated that more than a third of adults and around a fifth of children and adolescents are obese.

18 Since obesity is a key risk factor for a variety of health conditions - including heart disease, type 2 diabetes, and some forms of cancer - its prevalence has become a major public health concern. A primary cause of obesity is an energy imbalance, whereby a person takes in more calories than they use. This may occur as a result of an unhealthful diet, overeating, and lack of exercise. According to co-lead study author Dr. Bettina Wölnerhanssen, of the Department of Biomedicine at University Hospital Basel in Switzerland, there is a widespread belief that "a lack of self-control and discipline" is the key player in obesity. However, studies are increasingly proving that this is not the case, and that there are a number of metabolic factors involved. The new study from Dr. Wölnerhanssen and colleagues adds to the evidence. The team has uncovered a molecular mechanism in obese individuals that may prevent them from feeling full after a meal, which may cause them to eat more. The findings were recently published in the journal Scientific Reports. Findings may 'explain lack of satiation' To reach their findings, the researchers collected and examined samples of gastrointestinal tissue from 27 morbidly obese adults, both before and 3 months after they underwent laparoscopic sleeve gastrectomy (LSG) - a type of weight loss surgery. For comparison, the team also collected and analyzed gastrointestinal tissue samples from 24 lean adults. The analysis revealed that the gastrointestinal tissue taken from obese participants prior to LSG had significantly fewer enteroendocrine cells than the tissue samples of lean subjects. Obesity: 'Switch' in brain controls weight gain Obesity: 'Switch' in brain controls weight gain Researchers have discovered a brain "switch" that might contribute to obesity. READ NOW In response to food intake, enteroendocrine cells release hormones into the bloodstream that send signals to the brain, telling us when we are full. A reduction in enteroendocrine cells leads to a decrease in the release of these so-called satiety hormones, which may fuel an increase in food intake. Additionally, the researchers found that, prior to LSG, obese individuals demonstrated changes in the expression of transcription factors that regulate enteroendocrine cell

19 formation. "Deregulation of this regulatory network may lead to defective epithelial differentiation resulting in altered functions of the intestinal epithelium," note the authors. Interestingly, the analysis of tissue samples from obese participants taken after LSG showed that the number of enteroendocrine cells and the expression of transcription factors in gastrointestinal tisse was almost the same as that of the lean subjects. Overall, the researchers believe their study offers further evidence that obesity can develop as a result of metabolic factors. "[...] there is no doubt that metabolic factors are playing an important part. The study shows that there are structural differences between lean and obese people, which can explain lackof satiation in the obese." High cholesterol High cholesterol diagnosis tied to lower breast cancer risk?( Medical News Today: ) After investigating 14 years of study data on over 1 million people, researchers found that women diagnosed with high cholesterol had a lower odds of developing breast cancer, compared with women without high cholesterol. Speculating on the finding, they suggest that it shows that taking statins may protect against breast cancer and call for further research to confirm it. The researchers, from Aston University in the United Kingdom, recently presented their findings at the European Society of Cardiology ESC Congress 2017 in Barcelona, Spain, and report in the European Heart Journal. Breast cancer is cancer that begins when cells grow abnormally in breast tissue. Although men can also develop breast cancer, it is much more common in women.

20 Among women around the globe, breast cancer is the most common cancer and the fifth most common cause of cancer death. In 2012, nearly 1.7 million new cases - a quarter of all new cancer cases in women - were diagnosed worldwide. All animal cells need cholesterol to function normally and it is an essential component of cell walls. Cholesterol is also important for making vitamin D, compounds that aid digestion, and hormones. High cholesterol and disease The blood transports cholesterol around the body inside lipoproteins - droplets of fat covered with protein. However, having too much cholesterol in the blood is a well-established risk factor for cardiovascular conditions, such as heart attack and stroke. The researchers behind the new study also note that some studies have suggested that high blood cholesterol could be a risk for cancer. Ovarian cancer: Statins might be effective with diet control Ovarian cancer: Statins might be effective with diet control Discover how, under certain conditions, some statins might be effective against ovarian cancer. READ NOW "We previously found an association between having high cholesterol and developing breast cancer so we designed this study to follow up patients longitudinally and address the relationship more robustly," says Dr. Rahul Potluri, senior author of the study. He and his colleagues used data from the Algorithm for Comorbidities, Associations, Length of stay and Mortality (ACALM) study. Dr. Potluri founded the ACALM Study Unit at Aston Medical School. Lower odds of breast cancer The study collected information from over 1 million patients attending several hospitals in the North West of England between 2000 and The researchers pulled records from female participants aged 40 and over who were and were not diagnosed with high cholesterol at baseline (the start of the study period) and did not have breast cancer at that point. For their analysis, the team included 16,043 women who were diagnosed with high cholesterol and an age-matched group of the same number of women without high cholesterol for comparison. The average age of the women was 66 years.

21 After comparing the 14 years of follow-up data on the two groups, the researchers found a lower proportion of the high-cholesterol group developed breast cancer, compared with the group that did not receive such a diagnosis at baseline (0.5 percent compared with 0.8 percent). Further analysis revealed significantly lower odds of breast cancer in the high-cholesterol patients (odds ratio of 0.67), compared with the patients who had not received such a diagnosis. The group that had been diagnosed with high cholesterol at baseline also had lower rates of death compared with the group that had not (13.8 percent compared with 23.7 percent). After taking into account age, ethnicity, and other factors known to influence premature death, the researchers found that the high-cholesterol group had significantly lower odds of death (odds ratio 0.60). The team concludes that their large, longitudinal, retrospective study shows that diagnosis of high cholesterol "has a highly protective effect on the subsequent development of breast cancer." While thy did not investigate the underlying reasons for the results, the researchers suggest that "treatment with statins or a healthier lifestyle may contribute." They call for further studies to investigate the potential benefit of giving cancer patients medication to lower cholesterol. "If a diagnosis of high cholesterol leads to lower breast cancer rates this must either relate to something inherent in the condition or affected patients, or more likely, to treatment with widely used cholesterol lowering interventions such as statins." Low Fat (Dainik Gagaran: )

22 Sleeping कम न द ल न स ÍɉɅȡǒȣ क खतर (Dainik Gagaran: ) ल दन : ɉ ȣ ȣȳí ɉक èȡèø क f भ ȡ[Ü न द बह त Ǿȣह ज Í ȯȡ[ü न द ȣȳल त `Ʌट इप 2 ȡǒȣ ह न क खतर बढ़ ज त ह यह च त वन Ȱ ȡǓ ɉ न एक \ Ú क ब द ȣ ह ^ Ʌस झ व Ǒȡ गय ह म त - ȡ ȯ Úȡ Ʌ Í ȯर त Ʌ ȡ[Ü न द Ʌ@1Ȫ ȡ[j Ȳन न स 10 स ल क 4,525 Í ɉक Þ ɇ और एक Ĥæȡȣक ǐf यह \ Ú ȡ@^ Ʌप य गय ज Í ȯद र तक स त ɇउनक वजन कम थ और उनक फ ट म स क è Ʌभ ȡ ȧकम थ स न ȧ\ ^Ȳ Ǖ और Þ ÊǗ Ȫ क ȡ ȧ Ĥȡ करत ह 1कम स कम 10 घ ट ȧन द Ǿȣ: ǒħȯ ȧन शनल ȯã [ न 10 स ल तक क Í ɉक कम स कम 10 घ ट तक स न क स झ व Ǒȡह एक Ȫ ȡ[क Ǖȡǒ, श ध स

23 स मन आय ह स न क समय बढ़ कर ब ड फ ट क è और ट इप 2 ȡǒȣ क खतर क आस न स कम ȡ ज सकत ह `Û ɉȯआग बत य बचपन ɅÏ ȡȡ स न ȧ आदत Ǖȡèȡ ȧस हत स स ध त र पर ȲȲ ह त ह यह आग चलकर कई तरह क èȡèø स ब ध ȡɉ क आध र बन सकत ह 1हर Üȡ न द क समय बढ़ न क फ यद : \ Ú Ʌस मन आय अगर हर Üȡ स न क समय क औसतन आध घ ट बढ़ त ɇत इसस ब ड म स ^ȲȯÈ Ʌ0.1 ȪĒȡ ĤǓ [Ȣ ȧकम आत ह स थ ȣ^ȳ Ǖ ĤǓȪ Ʌभ 0.5 ĤǓ ȧ कम आत ह ^ ȧवजह स ट इप 2 ȡǒȣ क बढ़न क खतर कम ह त ह ^Ȳ Ǖ एक Ĥ ȡ क ȡȾ ह ज ȣʌþ श गर क ǓȲǒğ रखन क क म करत ह ट इप 2 ȡǒȣ Ʌȣ Ʌ^Ȳ Ǖ ȧ` ȡ ȡ ȡ ȧĥȡ ह त ह, जसस ` ȧȡğ ȡ ȧ कम ह ज त ह ल दन : ɉ ȣ ȣȳí ɉक èȡèø क f भ ȡ[Ü न द बह त Ǿȣह ज Í ȯȡ[ü न द ȣȳल त `Ʌट इप 2 ȡǒȣ ह न क खतर बढ़ ज त ह यह च त वन Ȱ ȡǓ ɉ न एक \ Ú क ब द ȣ ह ^ Ʌस झ व Ǒȡ गय ह म त - ȡ ȯ Úȡ Ʌ Í ȯर त Ʌ ȡ[Ü न द Ʌ@1Ȫ ȡ[j Ȳन न स 10 स ल क 4,525 Í ɉक Þ ɇ और एक Ĥæȡȣक ǐf यह \ Ú ȡ@^ Ʌप य गय ज Í ȯद र तक स त ɇउनक वजन कम थ और उनक फ ट म स क è Ʌभ ȡ ȧकम थ स न ȧ\ ^Ȳ Ǖ और Þ ÊǗ Ȫ क ȡ ȧ Ĥȡ करत ह 1कम स कम 10 घ ट ȧन द Ǿȣ: ǒħȯ ȧन शनल ȯã [ न 10 स ल तक क Í ɉक कम स कम 10 घ ट तक स न क स झ व Ǒȡह एक Ȫ ȡ[क Ǖȡǒ, श ध स स मन आय ह स न क समय बढ़ कर ब ड फ ट क è और ट इप 2 ȡǒȣ क खतर क आस न स कम ȡ ज सकत ह `Û ɉȯआग बत य बचपन ɅÏ ȡȡ स न ȧ आदत Ǖȡèȡ ȧस हत स स ध त र पर ȲȲ ह त ह यह आग चलकर कई तरह क èȡèø स ब ध ȡɉ क आध र बन सकत ह 1हर Üȡ न द क समय बढ़ न क फ यद : \ Ú Ʌस मन आय अगर हर Üȡ स न क समय क औसतन आध घ ट बढ़ त ɇत इसस ब ड म स ^ȲȯÈ Ʌ0.1 ȪĒȡ ĤǓ [Ȣ ȧकम आत ह स थ ȣ^ȳ Ǖ ĤǓȪ Ʌभ 0.5 ĤǓ ȧ कम आत ह ^ ȧवजह स ट इप 2 ȡǒȣ क बढ़न क खतर कम ह त ह ^Ȳ Ǖ एक Ĥ ȡ क ȡȾ ह ज ȣʌþ श गर क ǓȲǒğ रखन क क म करत ह ट इप 2 ȡǒȣ Ʌȣ Ʌ^Ȳ Ǖ ȧ` ȡ ȡ ȡ ȧĥȡ ह त ह, जसस ` ȧȡğ ȡ ȧकम ह ज त ह

24 ȡǓ ȡ दव ए \ ç प न स ȡǓ ȡ दव ए हट न क ȣ ȡ (Dainik Gagaran: ) \ èȡɉक \ ç प न स हत और ȡ[ क f ह बड़ खतर 1नई Ǒãȣ, ] ^f ÞãǗ: ȡǓ ȡ दव ओ स Į \ èȡɉ क \ ç प न ȡ[ क f एक बड़ खतर ह ȯǔã और भ रत य Ȫ ȡ[j Ȳन इसस प र प न क ȣ ȡ कर ȡ ह इस नई क ǐȯ\ èȡɉ क प न Ʌम ज द ȡǓ ȡ ȡȾ क ȡ ज सकत ह 1\ èȡɉ क \ ç प न Ʌ ȡ^ÈȪ Ȩè Ȫȡ^ और ^ Ȫè ȡȡ^ ज स ȡ^ȪèȰǑ दव ए ȣह त ɇ, जनक ^èȯȡ ɇ क उपच र क f ȡज त ह य दव ए आस न स ȣȳट टत ɇ@इस तरह \ è ȡ ɉक कचर न क वल ȡ[ क न कस न पह च त ह, ǔã ^Ȳ ȡ ɉ ȧस हत क f भ घ तक ह त ह ȡ^ȪèȰǑ दव ए म नव ȣ क f ग भ र और कभ न ȣ ह न व ल Ǖ ȡ ɉक क रण बनत ɇ@ जन \ è ȡ ɉ Ʌɇ क ȣ ɉक उपच र ह त ह, वह क \ ç प न Ʌइन दव ओ ȧ ȡȲġȡ\ ह त ह 1Ȫ ȡ[j Ȳन एक ऐस ȪȪȰ è ȡãȣघ ल ǐf È त य र ȡह, जसक ǐȯइस \ ç प न क उस तरह स फ ȡज सकत ह, जस तरह प यजल क èí ȡज त ह इस उपकरण क f एलईड ज स र शन क İȪ ȧ] æ ȡ ह त ह इस क f Ȱ ȡǓ ɉ न Ȱ è क Ǿ Ʌȡ^ȯǓ ȡ_h È ȡ^ क ĤȪ ȡ@यह आस न स `Þ ह न क स थ ȣब हद क रगर और ग र Ȱȡ ह त ह दव ओ क र कन क f Ȩȣ य च न Ȣस ȡãȣत य र ȧ@ ȯ\ Úɉस èç ह च क ह छ ट और Û आक र क Ȩȣ बड़ आक र ȧ ȡ^ȪèȰǑ दव ओ क र कन Ʌ ɇ@ ȣȳ, अगर य दव ए \ Û दव ओ क Ȳ[Ʌआकर ȡ ȡǓ Đ ȡf Ȳकर ल त ɇ त उस द र करन क f च न Ȣ ȧ ȡãȣक ĤȪ ȡज सकत ह इस \ Ú क f Ȫ ȡ[j Ȳन च न Ȣ ȧ ȡãȣक ^èȯȡ ȡ@1

25 Ghee (Hindustan: )