Reporting Checklist for Nature Neuroscience

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1 Corrsponding Author: Manuscript Numbr: Manuscript Typ: Nichoas C. Hindy NNBC537C Brif Communication Rporting Chckist for Natur Nuroscinc # Main Figurs: 3 # Suppmntary Figurs: 9 # Suppmntary Tabs: 0 # Suppmntary Vidos: 0 This chckist is usd to nsur good rporting standards and to improv th rproducibiity pubishd rsu. For mor information pas rad Rporting Lif Scincs Rsarch. Pas not that in th vnt pubi it is mandatory that authors incud a rvant mthodoogica and statistica information in th manuscript. cs rporti by figur xamp xamp Pas spcify th foowing information for ach pan rporting quantitativ data and whr ach itm is rportd (sction.g. Rsu & graph numbr. Each figur gnd shoud iday contain an xact samp siz (n for ach xprimnta group/condition whr n is an xact numbr and not a rang a car dfinition how n is dfind (for xamp x cs from x sics from x animas from x ittrs coctd ovr x days a dscription th statistica tst usd th rsu th ts any dscriptiv statistics and cary dfind rror bars if appicab. For any xprimn using custom statisti pas indicat th tst usd and sta obtaind for ach xprimnt. Each figur gnd shoud incud a statmnt how many tims th xprimnt shown was rpicatd in th ab; th dtais samp coction shoud b sufficinty car so that th rpicabiity th xprimnt is obvious to th radr. For xprimn rportd in th txt but not in th figurs pas us th graph numbr instad th figur numbr. Not: Man and standard dviation ar not appropriat on sma samps and potting indpndnt data poin is usuay mor informativ. Whn tchnica rpicats ar rportd rror and significanc masurs rfct th xprimnta variabiity and not th variabiity th bioogica procss; it is misading not to stat this cary. FIGURE NUMBER a rsu 6 TEST USED WHICH TEST? onway ANOVA unpaird t tst Fig. gnd Rsu 6 EXACT VALUE n DEFINED? mic from at ast 3 ittrs/group 5 sics from 0 mic 8 Rsu 6 DESCRIPTIVE STATS (AVERAGE VARIANCE REPORTED? man / SEM man / SEM Fig. gnd Rsu 6 P VALUE EXACT VALUE p = p = Fig. gnd Rsu 6 DEGREES OF FREEDOM & F/t/z/R/ETC VALUE VALUE F(3 36 =.97 t(8 =.808 Fig. gnd Rsu 6

2 FIGURE NUMBER Main Txt 6 b b b b b c c TEST USED WHICH TEST? ranova (x intraction btwn man a hippocampu s man a visua cortx ttst (CA/3/DG ttst (CA ttst (subicuum ttst (V ttst (V ttst (CA/3/DG ttst (CA EXACT VALUE n DEFINED? DESCRIPTIVE STATS (AVERAGE VARIANCE REPORTED? man / SEM; dot data poin man / SEM; dot data poin man / SEM; dot data poin man / SEM; dot data poin man / SEM; dot data poin man / SEM; dot data poin man / SEM; dot data poin man / SEM; dot data poin Fig. P VALUE EXACT VALUE p=0.006 Main Txt 6 DEGREES OF FREEDOM & F/t/z/R/ETC VALUE VALUE F(3=8.97 Main Txt 6 Fig. p=0.0 Fig. t(3=.53 Fig. Fig. p=0.0 Fig. t(3=.7 Fig. Fig. p=0.93 Fig. t(3=0.09 Fig. Fig. p=0.8 Fig. t(3=0. Fig. Fig. p=0.89 Fig. t(3=0.4 Fig. Fig. p=0.7 Fig. t(3=0.36 Fig. Fig. p=0.66 Fig. t(3=0.45 Fig.

3 c c c 3a 3a 3a 3b Sa Sa Sa ttst (subicuum ttst (V ttst (V ttst (V/ V for trias with corrct ttst (V/ V for trias with incorrct ttst (V/ V for trias with corrct vs. incorrct CA/DG Parson corration (rationship btwn CA/DG and V/V bootrap (CA/3/DG bootrap (CA bootrap (subicuum man / SEM; dot data poin man / SEM; dot data poin man / SEM; dot data poin man / SEM; dot data poin man / SEM; dot data poin Fig. p=0.57 Fig. t(3=0.58 Fig. Fig. p=0.004 Fig. t(3=3.7 Fig. Fig. p=0.0 Fig. t(3=.5 Fig. Fig. 3 p=0.00 Fig. 3 t(3=3.45 Fig. 3 Fig. 3 p=0.30 Fig. 3 t(3=.05 Fig. 3 p=0.03 Fig. 3 t(3=.3 Fig. 3 scattr pot dispays a data poin Fig. 3 p=0.00 Fig. 3 r(=0.60 Fig. 3 Fig. S p=0.004 Fig. S Fig. S p=0.008 Fig. S Fig. S p=0.95 Fig. S 3

4 Sa Sa Sb Sb Sb Sb Sb S3a S3a S3b S3b bootrap (V bootrap (V bootrap (CA/3/DG bootrap (CA bootrap (subicuum bootrap (V bootrap (V ttst (CA/ DG ttst (V/ V ttst (CA/ DG ttst (V/ V Unpr dictab trias Unpr dictab trias Unpr dictab trias Unpr dictab trias man / SEM; dot data poin man / SEM; dot data poin man / SEM; dot data poin man / SEM; dot data poin Fig. S p=0.77 Fig. S Fig. S p=0.87 Fig. S Fig. S p=0.70 Fig. S Fig. S p=0.65 Fig. S Fig. S p=0.95 Fig. S Fig. S p= Fig. S Fig. S p=0.0 Fig. S Fig. S3 p=0.40 Fig. S3 t(3=0.85 Fig. S3 Fig. S3 p=0.90 Fig. S3 t(3=0.3 Fig. S3 Fig. S3 p=0.55 Fig. S3 t(3=0.6 Fig. S3 Fig. S3 p=0.56 Fig. S3 t(3=0.60 Fig. S3 4

5 S4a S4a S4b S4b S4c S4c S5 S5 S6a ttst (CA/ DG action prdictab fu ttst (putamn action prdictab fu ttst (CA/ DG action prdictab cuaction ttst (putamn action prdictab cuaction ttst (CA/ DG action cu action ttst (putamn action cu action ttst (CA/ DG actionfixd cassification ttst (putamn actionfixd cassification Parson corration (rationship btwn voic RT and CA/DG prdictab Brainbhavi or corra tions man / SEM; dot data poin man / SEM; dot data poin man / SEM; dot data poin man / SEM; dot data poin man / SEM; dot data poin man / SEM; dot data poin man / SEM; dot data poin man / SEM; dot data poin scattr pot dispays a data poin Fig. S4 p=0.70 Fig. S4 t(3=0.39 Fig. S4 Fig. S4 p=0.5 Fig. S4 t(3=.50 Fig. S4 Fig. S4 p=0. Fig. S4 t(3=.66 Fig. S4 Fig. S4 p=0.05 Fig. S4 t(3=.05 Fig. S4 Fig. S4 p=0.9 Fig. S4 t(3=0. Fig. S4 Fig. S4 p=0.009 Fig. S4 t(3=.85 Fig. S4 Fig. S5 p=0.04 Fig. S5 t(3=.0 Fig. S5 Fig. S5 p=0.5 Fig. S5 t(3=0.65 Fig. S5 Fig. S6 p=0.086 Fig. S6 r(=0.36 Fig. S6 5

6 S6b S6c S6d S7a S7a S7a S7a S7b S7b Parson corration (rationship btwn voic RT and V/V prdictab Parson corration (rationship btwn voic RT and CA/DG Parson corration (rationship btwn voic RT and V/V ttst (CA/ DG to cuaction ttst (CA/ DG to ttst (V/ V to cuaction ttst (V/ V to ttst (CA/ DG to cu action ttst (CA/ DG to Brainbhavi or corra tions Brainbhavi or corra tions Brainbhavi or corra tions scattr pot dispays a data poin scattr pot dispays a data poin scattr pot dispays a data poin man / SEM; dot data poin man / SEM; dot data poin man / SEM; dot data poin man / SEM; dot data poin man / SEM; dot data poin man / SEM; dot data poin Fig. S6 p=0.007 Fig. S6 r(=0.54 Fig. S6 Fig. S6 p=0.63 Fig. S6 r(=0.0 Fig. S6 Fig. S6 p=0.9 Fig. S6 r(=0.0 Fig. S6 Fig. S7 p=0.0 Fig. S7 t(3=.64 Fig. S7 Fig. S7 p=0.03 Fig. S7 t(3=.9 Fig. S7 Fig. S7 p=0.34 Fig. S7 t(3=0.97 Fig. S7 Fig. S7 p=0.006 Fig. S7 t(3=3.00 Fig. S7 Fig. S7 p=0.93 Fig. S7 t(3=0.09 Fig. S7 Fig. S7 p=0. Fig. S7 t(3=.60 Fig. S7 6

7 S7b S7b S7c S7c S7c S7c S8a S8a ttst (V/ V to cu action ttst (V/ V to ttst (CA/ DG cu action to ttst (CA/ DG cu action to ttst (V/ V cu action to ttst (V/ V cu action to bootrap (V/V for trias with corrct CA/DG bootrap (V/V for trias with incorrct CA/DG man / SEM; dot data poin man / SEM; dot data poin man / SEM; dot data poin man / SEM; dot data poin man / SEM; dot data poin man / SEM; dot data poin Fig. S7 p=0.007 Fig. S7 t(3=.99 Fig. S7 Fig. S7 p=0.03 Fig. S7 t(3=.35 Fig. S7 Fig. S7 p=0.0 Fig. S7 t(3=.68 Fig. S7 Fig. S7 p=0.7 Fig. S7 t(3=.4 Fig. S7 Fig. S7 p=0.97 Fig. S7 t(3=0.03 Fig. S7 Fig. S7 p=0.3 Fig. S7 t(3=. Fig. S7 Fig. S8 p= Fig. S8 Fig. S8 p=0.8 Fig. S8 7

8 S8a S8b S9c S9c S9c S9c S9c S9c bootrap (V/V for trias with corrct vs. incorrct CA/DG bootrap (corration btwn CA/DG and V/V ttst ( prcds ttst ( prcds ttst (within TR 3 ttst (within TR 4 ttst (' prcds ' vs. 'within TR3' ttst (' prcds ' vs. 'within TR4' 3 3 Timco urs anaysi s Timco urs anaysi s Timco urs anaysi s Timco urs anaysi s Timco urs anaysi s Timco urs anaysi s rror bands ar sop with 95% Fig. S8 p=0.0 Fig. S8 Fig. S8 p=0.004 Fig. S8 man SEM Fig. S9 p=0.03 Fig. S9 t(3=.30 Fig. S9 man SEM Fig. S9 p=0.4 Fig. S9 t(3=0.84 Fig. S9 man SEM Fig. S9 p=0.5 Fig. S9 t(3=.50 Fig. S9 man SEM Fig. S9 p=0.76 Fig. S9 t(3=0.3 Fig. S9 p=0.3 Fig. S9 t(3=.5 Fig. S9 p=0.04 Fig. S9 t(3=. Fig. S9 8

9 Main Txt 8 Main Txt 8 Mt Bha ts Mt Bha ts Mt Bha ts Mt Stati sti Mt Stati sti ttst (CA/ DG for trias with corrct vs. incorrct V/V Parson corration (rationship btwn V/V and CA/DG ttst (prscan tst accuracy ttst (poscan tst accuracy ttst (voic RT for prdictab vs. trias ranova ( in ft vs. right hippocampu s ranova ( in ft vs. right visua cortx Mt Bha ts Mt Bha ts Mt Bha ts p=0.66 p=0.39 man SD man SD man SD Mt Bha ts Mt Bha ts Mt Bha ts p=.57*038 p=5.00*035 p=0.007 p=0.064 p=0.30 Main Txt 8 "(ps>.39 " Main Txt 8 "(ps>.39 " Mt Bha ts "(ps<.00 " Mt Bha ts "(ps<.00 " Mt Bha ts cs cs t(3=0.45 r(=0.8 t(3=9.00 t(3=37.37 t(3=.98 F(3=3.79 F(3=.5 9

10 Mt Stati sti Mt Stati sti Mt Rgi ons intr st Mt Rgi ons intr st Mt Rgi ons intr st Mt Rgi ons intr st ranova ( in ft vs. right hippocampu s ranova ( in ft vs. right visua cortx ttst (V3 ttst (V3 ttst (V4 ttst (V4 Rgion s intrs t Rgion s intrs t Rgion s intrs t Rgion s intrs t p=0.3 p=0.6 p=0.77 p=0.5 p=0.9 p=0.3 cs cs Rgions intrst Rgions intrst Rgions intrst Rgions intrst F(3=.05 F(3=0.5 t(3=0.30 t(3=.48 t(3=0. t(3=.3 Rgions intrst Rgions intrst Rgions intrst Rgions intrst 0

11 Mt Actio n dco di Mt Actio n dco di Mt Actio n dco di 3 Mt Actio n dco di 3 Mt GLM Mt GLM ttst (V/ V for trias with corrct vs. incorrct putamn Parson corration (rationship btwn putamn and V/V ttst ('CA/ DG ' vs. 'CA/DG action fu trias' ttst ('CA/ DG ' vs. 'CA/DG action cuaction trias' ranova (buttonprss RT for prdictab vs. trias ranova (buttonprss RT for fu vs. cu action trias 3 3 ds GLM ds GLM Rprsntativ figurs. Ar any rprsntativ imags shown (incuding Wstrn bo and immunohistochmistry/staining in th papr? p=0.3 p=0.9 p=0.03 p=0.43 p=0.4 p=0.57 No 3 3 GLM GLM t(3=.04 r(=0.8 t(3=.7 t(3=0.80 F(3=0.69 F(3= GLM GLM If so what figur(s?

12 . For ach rprsntativ imag is thr a car statmnt how many tims this xprimnt was succssfuy rpatd and a discussion any imitations in rpatabiity? If so whr is this rportd (sction graph #? cs and gnra mt. Is thr a justification th samp siz? If so how was it justifid? Whr (sction graph #? Evn if no samp siz cacuation was prformd authors shoud rport why th samp siz is adquat to masur thir ffct siz.. Ar statistica ts justifid as appropriat for vry figur? Whr (sction graph #? a. If thr is a sction summarizing th statistica mt in th mtho is th statistica tst for ach xprimnt cary dfind? b. Do th data mt th assumptions th spcific statistica tst you chos (.g. normaity for a mtric tst? Whr is this dscribd (sction graph #? c. Is thr any stimat varianc within ach group data? Is th varianc simiar btwn groups that ar bing statisticay compard? Whr is this dscribd (sction graph #? Ys athough th ffct siz for was not known advanc th samp siz was chosn to match a prvious fmri study with a simiar bha protoco. Ys graph Ys Ys. Additionay to b compty sur that our rsu did not ry on ths assumptions w usd nonmtric bootrap rsamping to confirm th randomffc significanc cassification for ach ROI as w as within and participant intractions btwn V/V prdiction and CA/DG comption. graph 3 Th varianc within ach group data is dpictd in th standard rror bars in Figurs and 3 and was simiar conditions. Figur gnd d. Ar ts spcifid as on or twosidd? A ts ar twosidd.. Ar thr adjustmn for mutip comparisons? W do not hav issus mutip comparisons. In our main anaysis w conductd an ANOVA with pannd comparisons targtd towards th intraction intrst. 3. Ar critria for xcuding data poin rportd? Was this critrion stabishd prior to data coction? Whr is this dscribd (sction graph #? wr xcudd if thy did not compt th study.

13 4. Dfin th mthod randomization usd to assign subjc (or samps to th xprimnta groups and to coct and procss data. If no randomization was usd stat so. Whr dos this appar (sction graph #? 5. Is a statmnt th xtnt to which invstigator knw th group aocation during th xprimnt and in assssing incudd? If no binding was don stat so. Whr (sction graph #? 6. For xprimn in iv vrtbrats is a statmnt compianc with thica guidins/rguations incudd? Whr (sction graph #? 7. Is th spcis th animas usd rportd? Whr (sction graph #? 8. Is th strain th animas (incuding background strains KO/ transgnic animas usd rportd? Whr (sction graph #? 9. Is th sx th animas/subjc usd rportd? Whr (sction graph #? 0. Is th ag th animas/subjc rportd? Whr (sction graph #?. For animas housd in a vivarium is th ight/dark cyc rportd? Whr (sction graph #?. For animas housd in a vivarium is th housing group (i.. numbr animas pr cag rportd? Whr (sction graph #? 3. For bha xprimn is th tim day rportd (.g. ight or dark cyc? Whr (sction graph #? For ach participant stimuus imags wr randomy assignd to b cus or s Stimui Thr wr thr randomy intrmixd tria typs Scan task Data coction and anaysis wr not prformd bind to th conditions th xprimnt. Ys. Ys 4. Is th prvious history th animas/subjc (.g. prior drug administration surgry bha tsting rportd? Whr (sction graph #? 3

14 a. If mutip bha ts wr conductd in th sam group animas is this rportd? Whr (sction graph #? 5. If any animas/subjc wr xcudd from anaysis is this rportd? Whr (sction graph #? Ragn a. How wr th critria for xcusion dfind? Whr is this dscribd (sction graph #? b. Spcify rasons for any discrpancy btwn th numbr animas at th bginning and nd th study. Whr is this dscribd (sction graph #?. Hav antibodis bn vaidatd for us in th systm undr study (assay and spcis? a. Is antibody cataog numbr givn? Whr dos this appar (sction graph #? b. Whr wr th vaidation data rportd (citation suppmntary information Antibodypdia? Whr dos this appar (sction graph #?. C in idntity a. Ar any c ins usd in this papr istd in th databas commony misidntifid c ins maintaind by ICLAC and NCBI Biosamp? Whr (sction graph #? b. If ys incud in th sction a scintific justification thir usindicat hr in which sction and graph th justification can b found. Ys two additiona wr rmovd from th scannr bfor compting th xprimnt and wr xcudd from data anaysis and rpacd. On participant was rmovd from th scannr ary du to xcssiv fatigu whi a scond participant was rmovd ary du to xcssiv movmnt. 4

15 c. For ach c in incud in th sction a statmnt that spcifis: th sourc th c ins hav th c ins bn authnticatd? If so by which mthod? hav th c ins bn tstd for mycopasma contamination? Whr (sction graph #? Data dposition Data dposition in a pubic rpository is mandatory for: a. Protin DNA and RNA s b. Macromocuar structurs c. Crystaographic data for sma mocus d. Microarray data Dposition is strongy rcommndd for many othr datas for which structurd pubic rpositoris xist; mor dtais on our data poicy ar avaiab hr. W ncourag th provision othr sourc data in suppmntary information or in unstructurd rpositoris such as Figshar and Dryad. W ncourag pubication Data Dscriptors (s Scintific Data to maximiz data rus.. Ar accssion cods for dposit dats providd? Whr (sction graph #? Computr cod/stwar Any custom agorithm/stwar that is cntra to th mt must b suppid by th authors in a usab and radab form for radrs at th tim pubication. Howvr rfrs may ask for this information at any tim during th rviw procss.. Idntify a custom stwar or scrip that wr rquird to conduct th study and whr in th procdurs ach was usd.. If computr cod was usd to gnrat rsu that ar cntra to th papr's concusions incud a statmnt in th sction undr "Cod avaiabiity" to indicat whthr and how th cod can b accssd. Incud vrsion information as ncssary and any rstrictions on avaiabiity. Human subjc. Which IRB approvd th protoco? Whr is this statd (sction graph #? Data and cod ar avaiab upon rqust from th first author (nhindy@princton.du Cod avaiabiity Princton Univrsity Institutiona Rviw Board.. Is dmographic information on a subjc providd? Whr (sction graph #? Ys summary dmographic information is providd. 5

16 3. Is th numbr human subjc thir ag and sx cary dfind? Whr (sction graph #? 4. Ar th incusion and xcusion critria (if any cary spcifid? Whr (sction graph #? 5. How w wr th groups matchd? Whr is this information dscribd (sction graph #? 6. Is a statmnt incudd confirming that informd consnt was obtaind from a subjc? Whr (sction graph #? 7. For pubication patint photos is a statmnt incudd confirming that consnt to pubish was obtaind? Whr (sction graph #? fmri studis Ys Ys A subjc wr righthandd and had norma or corrctdtonorma vision. Additionay most anayss wr withinsubjct. Ys For paprs rporting functiona imaging (fmri rsu pas nsur that ths minima rporting guidins ar mt and that a this information is cary providd in th mt:. Wr any subjc scannd but thn rjctd for th anaysis aftr th data was coctd? a. If ys is th numbr rjctd and rasons for rjction dscribd? Whr (sction graph #?. Is th numbr bocks trias or xprimnta uni pr sssion and/ or subjc spcifid? Whr (sction graph #? 3. Is th ngth ach tria and intrva btwn trias spcifid? Ys 4. Is a bockd vntratd or mixd dsign bing usd? If appicab pas spcify th bock ngth or how th vntratd or mixd dsign was optimizd. Ys. Two additiona wr rmovd from th scannr bfor compting th xprimnt and wr xcudd from data anaysis and rpacd. Ys. On participant was rmovd from th scannr ary du to xcssiv fatigu whi a scond participant was rmovd ary du to xcssiv movmnt. Ys Scan task Th ordr tria typs within ach run and th intrstimuus intrva for ach tria was optimizd for statistica powr using opq. Scan task 5. Is th task dsign cary dscribd? Whr (sction graph #? Ys Scan task 6

17 6. How was bha prformanc masurd? Bha prformanc was masurd in th scannr through a st rspons box for ach hand. Ouid th scannr button prsss and vrba rsponss wr rcordd using a aptop with a microphon. 7. Is an ANOVA or factoria dsign bing usd? A rpatdmasurs ANOVA is usd to compar data masurs and ROIs. 8. For data acquisition is a who brain scan usd? If not stat ara acquisition. No. A partia (highrsoution voum was acquird. MRI acquisition a. How was this rgion dtrmind? Hypothss wr spcific to hippocampus and ary visua cortx. Obiqu sics for ach participant wr acquird to incud both ROIs. 9. Is th fid strngth (in Tsa th MRI systm statd? Ys a. Is th pus typ (gradint/spin cho EPI/spira statd? b. Ar th fidviw matrix siz sic thicknss and TE/TR/ fip ang cary statd? 0. Ar th stwar and spcific mtrs (mod/functions smoothing krn siz if appicab tc. usd for data procssing and prprocssing cary statd?. Is th coordinat spac for th anatomica/functiona imaging data cary dfind as subjct/nativ spac or standardizd strotaxic spac.g. origina Taairach MNI305 ICBM5 tc? Whr (sction graph #?. If thr was data normaization/standardization to a spcific spac tmpat ar th typ transformation (inar vs. noninar usd and imag typs bing transformd cary dscribd? Whr (sction graph #? 3. How wr anatomica ocations dtrmind.g. via an automatd abing agorithm (AAL standardizd coordinat databas (Taairach damon probabiistic atass tc.? 4. Wr any additiona rgrssors (bha covariats motion tc usd? Ys Ys Ys Ys. Primary anayss wr prformd in subjct/nativ spac. Mutivariat sarchight anayss and ROI anayss for V3 and V4 wr prformd in standardizd spac basd on th MNI5 tmpat. Prprocssing Anatomica ocations hippocampa ROIs wr dtrmind using ASHS machinarning toobox and a databas manua sgmntations. Anatomica ocations V and V wr dtrmind using probabiistic atass providd in Frsurfr. Anatomica ocations V3 V4 and mutivariat sarchigh wr dtrmind using probabiistic atass in MNI spac. Ys motion mtrs wr modd as nuisanc covariats. Prprocssing 5. Is th contrast construction cary dfind? 6. Is a mixd/random ffc or fixd infrnc usd? Random ffc 7

18 a. If fixd ffc infrnc usd is this justifid? 7. Wr rpatd masurs usd (mutip masurmn pr subjct? Ys a. If so ar th mthod to account for within subjct corration and th assumptions mad about varianc cary statd? 8. If th thrshod usd for infrnc and visuaization in figurs varis is this cary statd? Ys th intraction was tstd with a rpatdmasurs ANOVA. Pairdsamp tts wr usd to compar cassifir accuracis for ach participant basd on corrct or incorrct CA/DG comption. Additionay nonmtric prmutation ts wr usd to confirm th randomffc significanc cassification for ach ROI as w as rationships btwn V/V prdiction and CA/DG comption. graph 9. Ar statistica infrncs corrctd for mutip comparisons? Ys sarchight anayss ar custrcorrctd. ROI anayss do not hav issus mutip comparisons. W conductd an ANOVA in th primary anaysis with pannd comparisons targtd towards th intraction intrst. a. If not is this abd as uncorrctd? 0. Ar th rsu basd on an ROI (rgion intrst anaysis? Ys a. If so is th rationa cary dscribd? Ys b. How wr th ROI s dfind (functiona vs anatomica ocaization? ROIs wr dfind anatomicay. Hippocampa ROIs (CA/3/DG CA subicuum and CA/DG wr dfind using ASHS machinarning toobox and a databas manua sgmntations from a st st. Eary visua cortx ROIs for primary anayss (V V and V/V wr dfind using probabiistic atass providd in Frsurfr. Eary visua cortx ROIs for additiona anayss (V3 and V4 wr dfind using a probabiistic atas in MNI spac.. Is thr corrction for mutip comparisons within ach vox? No (appis ony to sarchight anayss. For custrwis significanc is th custrdfining thrshod and th corrctd significanc v dfind? Additiona commn Additiona Commn Ys (appis ony to sarchight anayss. Group sarchight maps wr corrctd for mutip comparisons at p<.05 with a voxwis α p<0.00 and a custrsiz thrshod cacuatd using 3dCustSim basd on th smoothnss ach group sarchight map (from 3dFWHMx. 8