Alzheimer s Disease without Dementia
|
|
- Aileen Elliott
- 5 years ago
- Views:
Transcription
1 Alzheimer s Disease without Dementia Dr Emer MacSweeney CEO & Consultant Neuroradiologist Re:Cognition Health London Osteopathic Society 13 September 2016
2 Early diagnosis of Alzheimer s Disease How and why? Innovations in Clinical Research for AD Alzheimer s without Dementia
3 Understanding Cognitive Impairment in 2016 Alzheimer s Disease with Dementia Changing the trajectory of Alzheimer's MCI & Alzheimer s Disease without Dementia What is happening in the brain in AD What s new on the horizon in this rapidly developing space Emerging treatments: to slow progression of AD boost memory / cognition
4 Cognitive Impairment: Problems with any aspect of thinking ability Insight Concentration Abstract Thought Planning Judgment Concept formation Working memory Inhibition Problem solving Memory Cognition Executive Function Visuo-spatial skills Speech and language Calculation
5 Cognitive Impairment Why is this a challenge? All ages Multiple causes Coexisting morbidities Symptoms not specific Frequently of gradual onset Often requires multiples specialists working in an integrated team
6 The Challenge Acquired brain injury (ABI) ADHD Stroke /TIA PTSD Stress/ anxiety Encephalitis Chemo Radiotherapy Normal pressure hydrocephalus Traumatic brain injury Vascular disease Brain tumours Drugs/ Alcohol Depression Subdural haematoma Cognitive Impairment Parkinson CAA Frontotemporal Mild and progressive neurodegenerative disease HIV Epilepsy MS MCI Alzheimer s disease Lewy body
7 Dementia and Alzheimer s Disease To meet criteria for dementia, cognitive impairment must be in two domains, progressive, and impact on activities of daily living Diagnostic guidelines refer to Alzheimer s Disease dementia a clinical syndrome where criteria for dementia are also met McKhann et al: Alzheimer s Dementia May ; 7(3):
8 Early diagnosis: in 2016 what s the point? Understanding and choice opens doors Drugs and non-drug interventions Exclude other reversible causes of symptoms, e.g. depression Care-giver education / support Improved access to medical and social services Maintain independence longer / delay care home Planning the future (wills, PoA, care needs) Eligibility for CLINICAL TRIALS AND CHANCE TO CHANGE OUTCOME
9 Changing the Trajectory of Alzheimer s Disease Alzheimer s is the only leading cause of death that is still on the rise Based on USA data, a treatment breakthrough by 2015 that delays age of onset of AD by 5 years would result in: Reduction in the number of age 65+ with SEVERE AD of 54% reduction in those 65+ with severe Alzheimer s by % reduction in those 65+ with severe Alzheimer s by 2050 Alzheimer s Association, 2011 Alzheimer s Disease Facts and Figures, Alzheimer s & Dementia Volume 7, Issue 2 (issued March, 2011)
10
11 How has diagnosis advanced - historically
12 How has diagnosis advanced
13 52 year old lawyer
14 52 year old lawyer
15 Diagnostics amyloid imaging 52 year old lawyer 86% of MCI patients with positive amyloid PET amyloid scan develop clinical AD over 3 years
16 Alzheimer s disease without dementia? Mild Cognitive Impairment (MCI) Cognitive decline greater that that expected for age and education level but does not interfere with ADLs Can be seen as an entity with high risk for conversion to dementia High rate of conversion to AD > 60% over 3 yrs
17 Alzheimer s without and with Dementia
18 Symptoms of Early Cognitive Impairment MCI ADLs intact Repeatedly asking same question Trouble remembering recent or past events Losing or misplacing items Depression, anger, anxiety and agitation 18
19 What causes Alzheimer s Disease Can we slow its progression? β Amyloid plaques, extracellular Abnormal Tau protein neurofibrillary tangles = > neuronal and synaptic loss
20 Current and Emerging Mechanisms for Treatment for AD Symptomatic drugs New Disease Modifying Treatments New Symptomatic Treatments New Rx In Phase II/III Clinical Trials for Alzheimer s Disease
21 Symptomatic vs Disease Modifying Treatments The death of brain cells in Alzheimer's is currently unstoppable. Current medications = symptomatic Aricept/Donepezil, Galantamine, Rivastigmine o Managing only the symptoms of dementia by helping the dying brain cells function better. New medications: o Disease modifying drugs aimed to keep the brain cells alive reduce B amyloid & Tau Protein in the brain. o More effective Symptomatic drugs
22 Disease Modifying Drugs To reduce amyloid protein plaque synthesis/deposition/clearance.
23 Disease Modifying Drug To reduce Tau Protein Tau protein normally stabilises axonal microtubules With permission Prof Claude Wischik Microtubules inside axon critical for neurones to communicate with other parts of the brain : cortico-cortical association circuits Abnormal Tau Protein replicates and forms neurofibrillay tangles (Alzheimer s discovery) 23
24 Tau-aggregation cascade is prion-like Initial nucleation of Tau appears to require Amyloid APP fragment Once initiated Tau aggregation cascade is self-propagating and exponential ie turbo-charged leading to cell destruction 24
25 Tau Protein Tau aggregation is highly correlated with clinical dementia in AD Tau aggregation is self-propagating New Tau Aggregation Inhibitor (TAI) in clinical development To dissolve and enhances clearance of pathological Tau from AD brain
26 Spread of pathology and Braak staging Synapse Nerve Axon Toxic Tau oligomer passes to next cell Stages 4-6 Stages 1-3 Stages
27 Symptomatic Treatments
28 New treatments Disease Modifying: Anti Tau Proteinopathy Treatments Anti amyloid treatments: Symtomatic: Enhance neuro transmitters
29 Final Phase Clinical Trials for New Medications All medications prior to international license To confirm results from earlier studies Large number of participants across the world Double blind randomised Open label extension
30 Disease Modifying Drugs To reduce amyloid protein By increasing clearance of amyloid plaques. By reducing production of ab-amyloid
31 Amaranth Astra Zeneca Eli Lilly Amyloid Disease Modifying Treatment currently enrolling The AMARANTH Phase II/III clinical trial AZD3293 1,500 + patients Inhibits production of the abeta amyloid by80-90%
32 Amaranth Global Sites
33 OTHER New Disease Modifying treatment Studies 2016 New Studies 2016/2017 To reduce production and increase clearance of Amyloid Preclinical / Prodromal(MCI) / Mild AD MMSE 20-30
34 AXOVANT Mindset New Enhanced Symptomatic Rx A selective 5-HT6 receptor antagonist. Mild/ Moderate AD MMSE Donepezil 6/12 and 2/12 (stable dose) No Memantine
35 No Drug Axovant Drug + Donepezil / Aricept
36 Overcoming the clinical challenges: new AD paradigm Clinical research Medical care; Differential diagnosis Pathological continuum continuum Normal Preclinical Stage MCI/ Prodromal AD Alzheimer s disease AD is a clinical-biological entity with a clinical phenotype ranging from normal cognition to severe dementia Specific symptoms imply that we are in the clinical spectrum of the continuum Biomarkers, if correlate with pathology, indicate that we are within the continuum AD, Alzheimer s disease; Dubois B, et al. Lancet Neurol 2010;9(11): C-PIB PET is not approved for clinical use.
37 Revised dynamic biomarkers of the hypothetical Alzheimer s disease pathological cascade model Jack CR, Jr. et al. Lancet Neurol 2013;12(2):
38 Management of individuals with MCI/AD How to access clinical Trials? Physical exercise Diet Medical Rx: BP etc Souvenaid Early diagnosis empowers individuals Cognitive interventions Cranial Stimulation Cerebral protective agents Cerebral enhancing agents Non-pharmacological Pharmacological 38 Lin F, et al. J Gerontol Nurs. 2012;38(12):22-35
39 Implications of epidemiological analysis ALZHEIMER S DISEASE IS AN UNACCEPTABLE PROBLEM AD is a self-propagating pathology that spreads through the brain It is extremely widespread and presents a global problem for all aging societies Management should be as for any common chronic condition that begins in middle age 39
40 International message for the public: Run, don t walk if you get a diagnosis. The earlier, the better Clinical research is unlocking answers < 4-5 years before drugs available outside trials International Phase 3 Clinical Trials don t miss the opportunity now
41 Discussion Contact details: Dr Emer MacSweeney
42
43
44
Diagnosis and Treatment of Alzhiemer s Disease
Diagnosis and Treatment of Alzhiemer s Disease Roy Yaari, MD, MAS Director, Memory Disorders Clinic, Banner Alzheimer s Institute 602-839-6900 Outline Introduction Alzheimer s disease (AD)Guidelines -revised
More informationThe Aging Brain The Aging Brain
The Aging Brain The Aging Brain R. Scott Turner, MD, PhD Director, Memory Disorders Program Professor, Department of Neurology Georgetown University Washington, DC memory.georgetown.edu rst36@georgetown.edu
More informationAssessing and Managing the Patient with Cognitive Decline
Assessing and Managing the Patient with Cognitive Decline Center of Excellence For Alzheimer s Disease for State of NY Capital Region Alzheimer s Center of Albany Medical Center Earl A. Zimmerman, MD Professor
More informationImproving diagnosis of Alzheimer s disease and lewy body dementia. Brain TLC October 2018
Improving diagnosis of Alzheimer s disease and lewy body dementia Brain TLC October 2018 Plan for this discussion: Introduction to AD and LBD Why do we need to improve diagnosis? What progress has been
More informationDISCLOSURES. Objectives. THE EPIDEMIC of 21 st Century. Clinical Assessment of Cognition: New & Emerging Tools for Diagnosing Dementia NONE TO REPORT
Clinical Assessment of Cognition: New & Emerging Tools for Diagnosing Dementia DISCLOSURES NONE TO REPORT Freddi Segal Gidan, PA, PhD USC Keck School of Medicine Rancho/USC California Alzheimers Disease
More informationForm D1: Clinician Diagnosis
Initial Visit Packet Form D: Clinician Diagnosis NACC Uniform Data Set (UDS) ADC name: Subject ID: Form date: / / Visit #: Examiner s initials: INSTRUCTIONS: This form is to be completed by the clinician.
More informationMemory Loss, Dementia and Alzheimer's Disease: The Basics
Memory Loss, Dementia and Alzheimer's Disease: The Basics What is memory loss? What is age-related memory loss? Typical changes Typical age-related changes involve: Making a bad decision once in a while
More informationMemory Matters: Learning Objectives: Synapses, Age, and Health. Neuronal Synapses DISCLOSURE DECLARATION. Cognition and Normal Aging
Standard Deviations from Mean Memory Matters: Preventing and Treating Late-Life, Cognitive Decline Daniel L. Murman, MD, MS Director, Behavioral and Geriatric Neurology Program Professor & Vice Chair,
More informationDr. Michael Lobatz Dr. Michael Jackson Dr. James Brewer Dr. Paul Aisen. Dr. Michael Plopper. Dr. Guerry Peavy
1 Anne State 2 3 Dr. Michael Lobatz Dr. Michael Jackson Dr. James Brewer Dr. Paul Aisen Dr. Michael Plopper Dr. Guerry Peavy 4 Michael Lobatz, MD Medical Director, Neurosciences Medical Director, Rehabilitation
More informationUnderstanding Symptoms, Causes, and Risks for Alzheimer s Disease
Understanding Symptoms, Causes, and Risks for Alzheimer s Disease Gene E. Alexander, Ph.D., Professor of Psychology, Neuroscience, and Physiological Sciences; Director, Brain Imaging, Behavior & Aging
More informationOverview of neurological changes in Alzheimer s disease. Eric Karran
Overview of neurological changes in Alzheimer s disease Eric Karran Alzheimer s disease Alois Alzheimer 1864-1915 Auguste D. 1850-1906 Case presented November 26 th 1906 Guildford Talk.ppt 20 th March,
More information4/11/2017. The impact of Alzheimer s disease. Typical changes. The impact of Alzheimer s disease. Problematic changes. Problematic changes
The impact of Alzheimer s disease Ron Petersen, MD, PhD, is Director of the Mayo Alzheimer's Disease Research Center. 2 The impact of Alzheimer s disease Typical changes Typical age-related changes involve:
More informationDementia Basics. Welcome! What to expect and how to handle a dementia diagnosis. In partnership with Scripps Health.
Dementia Basics What to expect and how to handle a dementia diagnosis March 18, 2017 In partnership with Scripps Health Welcome! 1 Welcome Kristin Gaspar San Diego County Supervisor District 3 2 Our Mission:
More information#CHAIR2015. Miami, Florida. September 24 26, JW Marriott Miami. Sponsored by
#CHAIR2015 September 24 26, 2015 JW Marriott Miami Miami, Florida Sponsored by Case Challenge Workshop Alzheimer s Disease Anand Kumar, MD University of Illinois at Chicago, College of Medicine Chicago,
More informationOutline. Facts and figures Action plans Early / correct diagnosis Conclusions
Outline Facts and figures Action plans Early / correct diagnosis Conclusions Dementia: the greatest chalenge. Time to act now Philip Scheltens Professor of Neurology VU University Medical Center Amsterdam
More informationAlzheimer s disease is an
Alzheimer s Disease FACT SHEET Alzheimer s disease is an irreversible, progressive brain disease that slowly destroys memory and thinking skills, and eventually even the ability to carry out the simplest
More informationEvaluations. Alzheimer s Disease A Public Health Response. Viewer Call-In. July 19, Guest Speakers. Thanks to our Sponsors:
Alzheimer s Disease A Public Health Response July 19, 2007 1 2 Guest Speakers Thanks to our Sponsors: Earl A. Zimmerman, M.D. Bender Endowed Chair of Neurology and Director of the Alzheimer s Center at
More informationDEMENTIA, THE BRAIN AND HOW IT WORKS AND WHY YOU MATTER
OVERCOMING THE CHALLENGES OF MANAGING CHRONIC DISEASES IN PERSONS WITH DEMENTIA DEMENTIA, THE BRAIN AND HOW IT WORKS AND WHY YOU MATTER LEARNING OBJECTIVES Be familiar with the diagnostic criteria for
More informationAlzheimer s Disease Update: From Treatment to Prevention
Alzheimer s Disease Update: From Treatment to Prevention Jeffrey M. Burns, MD Edward H. Hashinger Professor of Medicine Co-Director, KU Alzheimer s Disease Center Director, Clinical and Translational Science
More informationThe ABCs of Dementia Diagnosis
The ABCs of Dementia Diagnosis Dr. Robin Heinrichs, Ph.D., ABPP Board Certified Clinical Neuropsychologist Associate Professor, Psychiatry & Behavioral Sciences Director of Neuropsychology Training What
More informationEvaluation and Treatment of Dementia
Evaluation and Treatment of Dementia Jeffrey M. Burns, MD Edward H. Hashinger Professor of Neurology Co-Director, KU Alzheimer s Disease Center Director, Clinical and Translational Science Unit Disclosures
More informationStephen Salloway, M.D., M.S. Disclosure of Interest
Challenges in the Early Diagnosis of Alzheimer s Disease Stephen Salloway, MD, MS Professor of Neurology and Psychiatry Alpert Medical School, Brown University 2 nd Annual Early Alzheimer s Educational
More informationResources: Types of dementia
1/5 Dementia is an umbrella term for a number of progressive conditions affecting the functioning of the brain. Different types of dementia have different causes. There are a great number of rare forms.
More informationWhat is dementia? What is dementia?
What is dementia? What is dementia? What is dementia? Dementia is an umbrella term for a range of progressive conditions that affect the brain. It has been identified that there are over 200 subtypes of
More informationIf you have dementia, you may have some or all of the following symptoms.
About Dementia Dementia may be caused by a number of illnesses that affect the brain. Dementia typically leads to memory loss, inability to do everyday things, difficulty in communication, confusion, frustration,
More informationDEMENTIA? 45 Million. What is. WHAT IS DEMENTIA Dementia is a disturbance in a group of mental processes including: 70% Dementia is not a disease
What is PRESENTS DEMENTIA? WHAT IS DEMENTIA Dementia is a disturbance in a group of mental processes including: Memory Reasoning Planning Learning Attention Language Perception Behavior AS OF 2013 There
More informationDementia, Cognitive Aging Services and Support
Dementia, Cognitive Aging Services and Support Ronald C. Petersen, Ph.D., M.D. Professor of Neurology Mayo Clinic College of Medicine Rochester, MN NASUAD Washington September 2, 2015 Disclosures Pfizer,
More informationImaging of Alzheimer s Disease: State of the Art
July 2015 Imaging of Alzheimer s Disease: State of the Art Neir Eshel, Harvard Medical School Year IV Outline Our patient Definition of dementia Alzheimer s disease Epidemiology Diagnosis Stages of progression
More informationDementia is not normal aging!
The Future of Alzheimer s Disease Treatment Adam L. Boxer, MD, PhD Director, Alzheimer s Disease Clinical Trials Program Memory and Aging Center Assistant Professor of Neurology University of California,
More informationMild Cognitive Impairment
Mild Cognitive Impairment Victor W. Henderson, MD, MS Departments of Health Research & Policy (Epidemiology) and of Neurology & Neurological Sciences Stanford University Director, Stanford Alzheimer s
More informationDr Georgina Train Consultant Psychiatrist EMDASS service and Continuing Care.
Dr Georgina Train Consultant Psychiatrist EMDASS service and Continuing Care. Consultant Psychiatrist of both General adult and Old Age Psychiatry. Work with Memory Service and a Continuing Care ward.
More informationCurrent Treatments for Dementia and Future Prospects. James Warner St Charles Hospital, London
Current Treatments for Dementia and Future Prospects James Warner St Charles Hospital, London Dementia Cognitive Non-cognitive (BPSD) Memory orientation language other cognitive abilities praxis planning
More informationDementia. Jeanette Norden, Ph.D. Professor Emerita Vanderbilt University School of Medicine
Dementia Jeanette Norden, Ph.D. Professor Emerita Vanderbilt University School of Medicine What is Dementia? Dementia is a general term referring to a decline in cognitive/mental functioning; this decline
More informationMOVEMENT DISORDERS AND DEMENTIA
MOVEMENT DISORDERS AND DEMENTIA FOCUS ON DEMENTIA WITH LEWY BODIES MADHAVI THOMAS MD NORTH TEXAS MOVEMENT DISORDERS INSTITUTE, INC DEMENTIA de men tia dəˈmen(t)sh(ē)ə/ nounmedicine noun: dementia a chronic
More information8/14/2018. The Evolving Concept of Alzheimer s Disease. Epochs of AD Research. Diagnostic schemes have evolved with the research
The Evolving Concept of Alzheimer s Disease David S. Geldmacher, MD, FACP Warren Family Endowed Chair in Neurology Department of Neurology UAB School of Medicine Epochs of AD Research Epoch Years Key Event
More informationAlzheimer s Disease. Fact Sheet. Fact Sheet. Fact Sheet. What Causes AD?
2 Alzheimer s Disease Dementia is a brain disorder that seriously affects a person s ability to carry out daily activities. The most common form of dementia among older people is Alzheimer s disease (AD),
More informationAlzheimer's disease (AD), also known as Senile Dementia of the Alzheimer Type (SDAT) or simply Alzheimer s is the most common form of dementia.
CHAPTER 3 Alzheimer's disease (AD), also known as Senile Dementia of the Alzheimer Type (SDAT) or simply Alzheimer s is the most common form of dementia. This incurable, degenerative, terminal disease
More informationDementia and cognitive decline
Dementia and cognitive decline Expert Briefing Su Ray and Dr Susan Davidson Research Department Together, we can help everyone to love later life 01 Brain basics Normal ageing, cognitive impairment and
More informationThe Basics of Alzheimer s Disease
2017 Memory Loss Conference The Basics of Alzheimer s Disease Tom Ala, MD Center for Alzheimer s Disease and Related Disorders Southern Illinois University School of Medicine Springfield, Illinois SIU
More informationWhat is dementia? What is dementia?
What is dementia? What is dementia? What is dementia? Dementia is an umbrella term for a range of progressive conditions that affect the brain. There are over 200 subtypes of dementia, but the five most
More informationDelirium & Dementia. Nicholas J. Silvestri, MD
Delirium & Dementia Nicholas J. Silvestri, MD Outline Delirium vs. Dementia Neural pathways relating to consciousness Encephalopathy Stupor Coma Dementia Delirium vs. Dementia Delirium Abrupt onset Lasts
More informationDementia Update. October 1, 2013 Dylan Wint, M.D. Cleveland Clinic Lou Ruvo Center for Brain Health Las Vegas, Nevada
Dementia Update October 1, 2013 Dylan Wint, M.D. Cleveland Clinic Lou Ruvo Center for Brain Health Las Vegas, Nevada Outline New concepts in Alzheimer disease Biomarkers and in vivo diagnosis Future trends
More informationCustom Intelligence. Alzheimer s Disease Landscape Summary
Custom Intelligence Alzheimer s Disease Landscape Summary Prepared August 21 Alzheimer s Disease Landscape: Executive Summary Current standard of care in Alzheimer s Disease (AD) consists of symptomatic
More informationUnderstanding Dementia
Dementia Handbook for Carers Essex Understanding Dementia What is dementia? 1 Summary of dementia symptoms 4 Medication and treatment 5 1 Dementia is the name for several conditions that lead to the progressive
More informationWhat if it s not Alzheimer s? Update on Lewy body dementia and frontotemporal dementia
What if it s not Alzheimer s? Update on Lewy body dementia and frontotemporal dementia Dementia: broad term for any acquired brain condition impairing mental function such that ADLs are impaired. Includes:
More informationWhat is dementia? Symptoms of dementia. Memory problems
What is dementia? What is dementia? What is dementia? Dementia is an umbrella term for a range of progressive conditions that affect the brain. The brain is made up of nerve cells (neurones) that communicate
More informationWHAT IS DEMENTIA? An acquired syndrome of decline in memory and other cognitive functions sufficient to affect daily life in an alert patient
DEMENTIA WHAT IS DEMENTIA? An acquired syndrome of decline in memory and other cognitive functions sufficient to affect daily life in an alert patient Progressive and disabling Not an inherent aspect of
More informationWhat is Neuropsychology?
Alzheimer s Disease Neurological Bases and Informed Behavioral Interventions Peter T. Keenan Clinical Neuropsychologist Marshfield Clinic Minocqua Center What is Neuropsychology? Science of the relationship
More informationAlzheimer's Disease. Dementia
Alzheimer's Disease Victor W. Henderson, MD, MS Departments of Health Research & Policy (Epidemiology) and of Neurology & Neurological Sciences Stanford University Director, Stanford Alzheimer s Disease
More informationInception, Total Recall, & The Brain: An Introduction to Neuroscience Part 2. Neal G. Simon, Ph.D. Professor Dept. of Biological Sciences
Inception, Total Recall, & The Brain: An Introduction to Neuroscience Part 2 Neal G. Simon, Ph.D. Professor Dept. of Biological Sciences http://www.youtube.com/watch?v=wfmlgeh dije Summary from September
More informationA BRIEF LOOK AT DEMENTIA
Dementia A BRIEF LOOK AT DEMENTIA David Kaufman, MD Neurology Consultants of Bellin Health November 2, 2017 Defined as a progressive decline in cognitive function that impairs daily activities. Always
More informationThe Impact of Ageing & Dementia for People with Down Syndrome. Evelyn Reilly Clinical Nurse Specialist Dementia
The Impact of Ageing & Dementia for People with Down Syndrome Evelyn Reilly Clinical Nurse Specialist Dementia We need to support a rapidly expanding older population with Down syndrome. Ageing & Down
More informationDementia NICE Guidelines Update. Key points for primary care - NICE guideline (June 2018 update ) 26 September 2018
Dementia NICE Guidelines Update Key points for primary care - NICE guideline (June 2018 update ) 26 September 2018 How NICE guidelines are reviewed Multidisciplinary guideline committee established Review
More informationDementia. Aetiology, pathophysiology and the role of neuropsychological testing. Dr Sheng Ling Low Geriatrician
Dementia Aetiology, pathophysiology and the role of neuropsychological testing Dr Sheng Ling Low Geriatrician Topics to cover Why is dementia important What is dementia Differentiate between dementia,
More informationChanging diagnostic criteria for AD - Impact on Clinical trials
Changing diagnostic criteria for AD - Impact on Clinical trials London, November 2014 Bruno Dubois Head of the Dementia Research Center (IMMA) Director of INSERM Research Unit (ICM) Salpêtrière Hospital
More informationOLD AGE PSYCHIATRY. Dementia definition TYPES OF DEMENTIA. Other causes. Psychiatric disorders of the elderly. Dementia.
Psychiatric disorders of the elderly OLD AGE PSYCHIATRY Dementia Depression Delusional disorder/late onset schizophrenia Delirium Dementia definition LOCALISATION OF CEREBRAL FUNCTION Impairment of multiple
More informationFact Sheet Alzheimer s disease
What is Alzheimer s disease Fact Sheet Alzheimer s disease Alzheimer s disease, AD, is a progressive brain disorder that gradually destroys a person s memory and ability to learn, reason, make judgements,
More informationWHEN THE GOING GETS TOUGH: Working Through the Challenges of Dementia Together. Presented by
WHEN THE GOING GETS TOUGH: Working Through the Challenges of Dementia Together Presented by Our agenda for today Understanding behavioral symptoms in people living with dementia Briefly review key strategies
More informationForgetfulness: Knowing When to Ask for Help
National Institute on Aging AgePage Forgetfulness: Knowing When to Ask for Help Maria has been a teacher for 35 years. Teaching fills her life and gives her a sense of accomplishment, but recently she
More informationWhat is dementia? alzheimers.org.uk
alzheimers.org.uk What is dementia? If you, or a friend or relative, have been diagnosed with dementia, you may be feeling anxious or confused. You may not know what dementia is. This factsheet should
More informationDementia. Memory Evaluation Center Neurology
Dementia Memory Evaluation Center Neurology Topics Overview of dementia Stages Medications Advanced planning What is Dementia? Dementia = significant global decline in cognitive function not due to medicine
More informationNew life Collage of nursing Karachi
New life Collage of nursing Karachi Presenter: Zafar ali shah Faculty: Raja khatri Subject: Pathophysiology Topic :Alzheimer s Disease Post RN BScN semester 2 nd Objective Define Alzheimer s Describe pathophysiology
More informationALZHEIMER S DISEASE. Mary-Letitia Timiras M.D. Overlook Hospital Summit, New Jersey
ALZHEIMER S DISEASE Mary-Letitia Timiras M.D. Overlook Hospital Summit, New Jersey Topics Covered Demography Clinical manifestations Pathophysiology Diagnosis Treatment Future trends Prevalence and Impact
More informationDEMENTIA 101: WHAT IS HAPPENING IN THE BRAIN? Philip L. Rambo, PhD
DEMENTIA 101: WHAT IS HAPPENING IN THE BRAIN? Philip L. Rambo, PhD OBJECTIVES Terminology/Dementia Basics Most Common Types Defining features Neuro-anatomical/pathological underpinnings Neuro-cognitive
More informationAlzheimer's Disease A mind in darkness awaiting the drink of a gentle color.
Alzheimer's Disease A mind in darkness awaiting the drink of a gentle color. Mary ET Boyle, Ph. D. Department of Cognitive Science UCSD Gabriel García Márquez One Hundred Years of Solitude Alois Alzheimer
More informationThe Person: Dementia Basics
The Person: Dementia Basics Objectives 1. Discuss how expected age related changes in the brain might affect an individual's cognition and functioning 2. Discuss how changes in the brain due to Alzheimer
More information2018 ALZHEIMER S DISEASE FACTS AND FIGURES. Includes a Special Report on the Financial and Personal Benefits of Early Diagnosis
2018 ALZHEIMER S DISEASE FACTS AND FIGURES Includes a Special Report on the Financial and Personal Benefits of Early Diagnosis About this report 2018 Alzheimer s Disease Facts and Figures is a statistical
More informationThe added value of the IWG-2 diagnostic criteria for Alzheimer s disease
The added value of the IWG-2 diagnostic criteria for Alzheimer s disease Miami, January 2016 Bruno Dubois Head of the Dementia Research Center (IMMA) Director of INSERM Research Unit (ICM) Salpêtrière
More informationRegulatory Challenges across Dementia Subtypes European View
Regulatory Challenges across Dementia Subtypes European View Population definition including Early disease at risk Endpoints in POC studies Endpoints in pivotal trials 1 Disclaimer No CoI The opinions
More informationAlzheimer s disease. The facts in brief
Alzheimer s disease Dementia is an umbrella term used to describe various conditions which damage brain cells and lead to a loss of brain function over time. Dementia causes a progressive decline in a
More informationUnderstanding Dementia
Understanding Dementia Dr. Dallas Seitz MD FRCPC Assistant Professor, Department of Psychiatry, Queen s University, Kingston, Ontario, Canada What s Next Information about Dementia, Elder Care and Supports
More informationBiomarkers for Alzheimer s disease
Biomarkers for Alzheimer s Disease Henrik Zetterberg, MD, PhD Professor of Neurochemistry The Sahlgrenska Academy, University of Gothenburg 1 Alzheimer s disease 2 Neuropathological criteria for Alzheimer
More informationAlzheimer s disease dementia: a neuropsychological approach
Alzheimer s disease dementia: a neuropsychological approach Dr. Roberta Biundo, PhD Neuropsychology Coordinator at Parkinson s disease and movement disorders unit of San Camillo rehabilitation hospital
More informationAlzheimer's Disease Brain Failure, Stopping the Momentum. Katherine E. Galluzzi, DO, CMD, FACOFP dist.
AOA/ACOFP 113th Annual Convention and Scientific Seminar Las Vegas, Nevada Alzheimer's Disease Brain Failure, Stopping the Momentum Katherine E. Galluzzi, DO, CMD, FACOFP dist. Monday, October 27, 2008
More informationIs PET/CT really helpful in diagnosing Alzheimer s Disease?
Is PET/CT really helpful in diagnosing Alzheimer s Disease? J. Rudolf MD Ph.D. Consultant in Neurology, Dept. of Neurology, General Hospital Papageorgiou Thessaloniki, Greece Conflict of Interest PET/CT
More informationAnnouncing a new era in Alzheimer s
EMBARGOED UNTIL 16:00 Monte Carlo Time 30 October 2012 Announcing a new era in Alzheimer s The time for Tau is now as Phase 3 clinical trials get under way with a second-generation Tau Aggregation Inhibitor
More informationDementia Chronic Brain Failure The forgotten cardiovascular disease Clare Hawley 2015
Dementia Chronic Brain Failure The forgotten cardiovascular disease Clare Hawley 2015 MB ChB, MRCGP, PG Dip Cardiol, PG Cert Med Ed Associate Specialist Cardiology Chesterfield Royal Hospital GPwSI Refractory
More informationDiagnosis and management of non-alzheimer dementias. Melissa Yu, M.D. Department of Neurology
Diagnosis and management of non-alzheimer dementias Melissa Yu, M.D. Department of Neurology AGENDA Introduction When to think of alternate diagnoses Other forms of dementia Other reasons for confusion
More informationHow can the new diagnostic criteria improve patient selection for DM therapy trials
How can the new diagnostic criteria improve patient selection for DM therapy trials Amsterdam, August 2015 Bruno Dubois Head of the Dementia Research Center (IMMA) Director of INSERM Research Unit (ICM)
More informationObjective 4/22/2019. Interaction of Cardiovascular Disease and Alzheimer s Disease: Implications for Cardiopulmonary Rehabilitation.
Interaction of Cardiovascular Disease and Alzheimer s Disease: Implications for Cardiopulmonary Rehabilitation Dereck Salisbury, PhD Assistant Professor, Clinical Exercise Physiologist Director: Laboratory
More informationInteraction of Cardiovascular Disease and Alzheimer s Disease: Implications for Cardiopulmonary Rehabilitation
Interaction of Cardiovascular Disease and Alzheimer s Disease: Implications for Cardiopulmonary Rehabilitation Dereck Salisbury, PhD Assistant Professor, Clinical Exercise Physiologist Director: Laboratory
More informationNeuropathology of old-age dementia
Australian Association of Gerontology Adelaide, September 22 2015 Neuropathology of old-age dementia University of Cambridge, Institute of Public Health Suvi R. K. Hokkanen, MD MPH srkh2@medschl.cam.ac.uk
More informationAlzheimer s Disease - Dementia
- Dementia Neurocognitive disorder with dysfunction or loss of " Memory " Orientation " Attention " Language " Judgment " Reasoning Other characteristics that can manifest " Personality changes " Behavioral
More informationNext patient please Dementia Clare Hawley 2018
Next patient please Dementia Clare Hawley 2018 I have no conflict of interest to declare Dr Clare Hawley Associate Specialist Cardiology Chesterfield Royal Hospital GPwSI Refractory Angina Hon Clinical
More informationDementia Past, Present and Future
Dementia Past, Present and Future Morris Freedman MD, FRCPC Division of Neurology Baycrest and University of Toronto Rotman Research Institute, Baycrest CNSF 2015 Objectives By the end of this presentation,
More informationDementia Update. Daniel Drubach, M.D. Division of Behavioral Neurology Department of Neurology Mayo Clinic Rochester, Minnesota
Dementia Update Daniel Drubach, M.D. Division of Behavioral Neurology Department of Neurology Mayo Clinic Rochester, Minnesota Nothing to disclose Dementia Progressive deterioration in mental function
More informationPlan for Today. Brain Injury: 8/4/2017. Effective Services for People Living with Brain Injury. What is it & what causes it?
Effective Services for People Living with Brain Injury Jean Capler, MSW, LSW Local Support Network Leader The Rehabilitation Hospital of Indiana Department of Resource Facilitation Plan for Today Brain
More informationDementia, Assessment, and Caregiver Resources
Dementia, Assessment, and Caregiver Resources Susan F. Randhawa, M.S.W., L.C.S.W. UCI Institute for Memory Impairments and Neurological Disorders with special thanks to: Malcolm B. Dick, Ph.D. & Cordula
More informationDementia: It s Not Always Alzheimer s
Dementia: It s Not Always Alzheimer s A Caregiver s Perspective Diane E. Vance, Ph.D. Mid-America Institute on Aging and Wellness 2017 My Background Caregiver for my husband who had Lewy Body Dementia
More informationAmyloid and the Vessels. David Weisman, M.D.
Amyloid and the Vessels David Weisman, M.D. CMA I conduct Alzheimer/amyloid clinical research in conjunction with: Toyoma, ADRC, Genentech, Eisai, Envivo, Accera, Elan, Merck. Previously served on speaker
More informationPROJECTION: Worlds dementia population is expected to triple by 2050
DEMENTIA C L I S K C O N S U LTA N T P H Y S I C I A N I N A C U T E M E D I C I N E A N D G E R I AT R I C M E D I C I N E, B A R N E T H O S P I TA L, R O YA L F R E E N H S F O U N D AT I O N T R U
More informationClinical Trials Research
Clinical Trials Research Miami Campus - Dr. Marc E Agronin, Principal Investigator Name of Study: Acadia (SERENE Study) ACP-103-032 Description of Study: This is a phase II study testing to see if an investigational
More informationFinding Solutions to the Alzheimer s Disease Epidemic in Indiana: Alzheimer s Research in Indiana
Finding Solutions to the Alzheimer s Disease Epidemic in Indiana: Alzheimer s Research in Indiana Bruce Lamb, Ph.D. Executive Director Stark Neurosciences Research Institute September 13, 2017 Critical
More informationUNDERSTANDING ALZHEIMER S AND DEMENTIA
UNDERSTANDING ALZHEIMER S AND DEMENTIA Geri T., living with Alzheimer's, and her husband and care partner, Jim T. THE IMPACT OF ALZHEIMER S AND DEMENTIA Currently, an estimated 50 million people worldwide
More informationNeuropsychological Evaluation of
Neuropsychological Evaluation of Alzheimer s Disease Joanne M. Hamilton, Ph.D. Shiley-Marcos Alzheimer s Disease Research Center Department of Neurosciences University of California, San Diego Establish
More informationObjectives Gain a better understanding of Alzheimer s disease and other dementias. Enhance ability to detect signs and symptoms of dementia and learn
Dementia Training provided through a Minnesota Department of Human Services Community Service Development Grant Project Catherine Johnson PsyD LP 1 Objectives Gain a better understanding of Alzheimer s
More information1 in 3 seniors dies with Alzheimer s or another dementia.
2013 Alzheimer s disease facts and figures Includes a Special Report on long-distance caregivers 1 in 3 seniors dies with Alzheimer s or another dementia. Out-of-pocket expenses for long-distance caregivers
More information3/6/2019 DIAGNOSIS OF DEMENTIA IN THE OUTPATIENT SETTING FINANCIAL DISCLOSURES LEARNING OBJECTIVES
DIAGNOSIS OF DEMENTIA IN THE OUTPATIENT SETTING MILTA LITTLE, DO, CMD DUKE UNIVERSITY SCHOOL OF MEDICINE FINANCIAL DISCLOSURES Dr. Little has no relevant financial disclosures to report Dr. Little will
More informationCHAPTER 15: NEUROCOGNITIVE DISORDERS KEY TERMS. Acetylcholine A neurotransmitter that appears to be involved in learning and memory.
CHAPTER 15: NEUROCOGNITIVE DISORDERS KEY TERMS Acetylcholine A neurotransmitter that appears to be involved in learning and memory. Adult Memory and Information Processing Battery (AMIPB) A neuropsychological
More information