Overview of neurological changes in Alzheimer s disease. Eric Karran
|
|
- Kelly McKinney
- 5 years ago
- Views:
Transcription
1 Overview of neurological changes in Alzheimer s disease Eric Karran
2 Alzheimer s disease Alois Alzheimer Auguste D Case presented November 26 th 1906 Guildford Talk.ppt 20 th March, 2006 M.J. O Neill Copyright 2006 Eli Lilly and Company
3 Alzheimer s disease major cause of dementia Alzheimer s disease 67% Parkinson s 8% Other 6% Vascular dementia 15% Injury 4%
4 AD clinical features AD is the most common cause of dementia: Evidence of a decline in memory and thinking which is of a degree sufficient to impair functioning in daily living, present for six months or more. According to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV), dementia is defined as memory impairment (amnesia) plus one or more of the following: aphasia - difficulty with language apraxia - problems with complex movements agnosia - difficulty with identifying objects impaired executive functioning - making everyday decisions Additional symptoms: Psychosis and agitation Mood change and apathy Diagnosis: Possible atypcial clinical features but no alternative diagnosis without histologic confirmation Probable typical clinical diagnosis without histologic confirmation Definite clinical diagnosis plus histologic confirmation
5 Mini-Mental State Exam Orientation What is the (year) (season) (date) (day) (month)? Where are we: (country) (city) (part of city) (number of flat/house) (name of street)? 5 5 Registration Name three objects: one second to say each. Then ask the patient to name all three after you have said them. Give 1 for each correct answer. Then repeat them until he learns all three. Count trials and record. 3 Attention and calculation Serial 7s: 1 for each correct answer, stop after five answers. Alternatively spell 'world' backwards. 5 Recall Ask for the three objects repeated above. Give 1 for each correct answer. Language Name a pencil and watch (2). Repeat the following: 'No ifs, ands or buts' (1). Follow a three-stage command: 'Take a paper in your right hand, fold it in half and put it on the floor (3). Read and obey the following: Close your eyes (1). Write a sentence (1). Copy a design (1). 3 9 Total = 30
6 AD - pathology Normal AD
7 Subtractive MRI AD - pathology 48 year old control over 11 months 46 year old AD patient over 14 months Nick Fox, Lancet 2001 Global loss of brain matter/year Controls = 0 24% At risk individuals = 1.0% Mild to moderate AD = 2 20%
8 Imaging pathology in the AD brain 71 years MMSE years MMSE 21 Amyloid plaques Brain tissue Oxygen use
9 AD- Pathophysiology Plaques Tangles Largely Aβ peptide Hyperphosphorylated tau filaments
10 APP metabolism 2 pathways Plaques Outside cell sappβ APP sappα β-secretase p3 α-secretase Aβ42 γ-secretase γ-secretase Inside cell AICD
11 Amyloid plaque is fibrillar and extracellular.
12 Tau protein: intracellular role in stabilizing microtubules
13 Tau can form aggregates in AD N N C C
14 Tau multiple forms of the protein and multiple phosphorylations Recomb. human tau AD brain: 4 PHF bands (60, 64, 68, 72 kda) Hyperphosphorylation reduces ability of tau to bind to microtubules Spillantini & Goedert (1998)
15 Axon in plaque with PHF and dense bodies near the synapse.
16 The tangle is made up of paired helical filaments (PHF) composed of hyperphosphorylated Tau.
17 What causes dementia in AD? Loss of synapses Loss of neurons Frontal cortex Price 2003
18 The progression of AD A I-II B III-IV C V - VI
19 Disease progression Phase IB/II Symptomatic Phase III Diagnosis Remaining life span after diagnosis (~10 years) Ernst, Hay Years
20 AD Staging and cognitive decline Stage Pathology Cognitive domain I II transentorhinal III IV limbic Entorhinal Cortex Mild involvement of HPC (CA1) EC / HPC subiculum (mild), Basal forebrain, Some cortical (frontal / temporal) Episodic memory Executive function Working memory V VI isocortical Severe cortical association areas, amygdala, thalamic, striatal, SN Extensive deficits not restricted to cognition
21 AD, PD, MS comparison Alzheimer s disease Parkinson s disease Multiple sclerosis Age of onset increases with age, most >60 increases with age, mean Gender distribution slight increase F slight increase M F>>M Patients in U.S. 4.3 million ~ 500,000 ~ 300,000 Initial clinical course insidious, gradually progressive insidious, gradually progressive relapsing/remitting Cognitive/ behavioral change Early; most prominent Normal early; change with advanced disease May occur, especially with progression. Motor system change Mild parkinsonism in ~20% Early change; bradykinesia, rigidity, resting tremor Yes, many manifestations
22 Prevalence of AD - USA Evans et al. Archs Neurol. 2003
23 Summary The pathology of AD has been rigorously documented: plaques and tangles are the hallmarks of the disease The actual mechanism(s) by which neurons are killed in the disease remain(s) obscure There are no therapies currently available that prevent or slow the progression of the disease Current symptomatic therapies offer only modest improvements in cognitive performance for a limited period of time.
Dementia. Assessing Brain Damage. Mental Status Examination
Dementia Assessing Brain Damage Mental status examination Information about current behavior and thought including orientation to reality, memory, and ability to follow instructions Neuropsychological
The Person: Dementia Basics
The Person: Dementia Basics Objectives 1. Discuss how expected age related changes in the brain might affect an individual's cognition and functioning 2. Discuss how changes in the brain due to Alzheimer
Dementia Update. October 1, 2013 Dylan Wint, M.D. Cleveland Clinic Lou Ruvo Center for Brain Health Las Vegas, Nevada
Dementia Update October 1, 2013 Dylan Wint, M.D. Cleveland Clinic Lou Ruvo Center for Brain Health Las Vegas, Nevada Outline New concepts in Alzheimer disease Biomarkers and in vivo diagnosis Future trends
Pathogenesis of Degenerative Diseases and Dementias. D r. Ali Eltayb ( U. of Omdurman. I ). M. Path (U. of Alexandria)
Pathogenesis of Degenerative Diseases and Dementias D r. Ali Eltayb ( U. of Omdurman. I ). M. Path (U. of Alexandria) Dementias Defined: as the development of memory impairment and other cognitive deficits
COGNITIVE ALTERATIONS IN CHRONIC KIDNEY DISEASE K K L E E
COGNITIVE ALTERATIONS IN CHRONIC KIDNEY DISEASE K K L E E Attention Problem Solving Language Cognitive Domains Decision Making Memory Reasoning The Cardiovascular Health Cognition Study shows higher S
Dementia. Aetiology, pathophysiology and the role of neuropsychological testing. Dr Sheng Ling Low Geriatrician
Dementia Aetiology, pathophysiology and the role of neuropsychological testing Dr Sheng Ling Low Geriatrician Topics to cover Why is dementia important What is dementia Differentiate between dementia,
MINI-MENTAL STATE EXA MINATION (M MSE)
MINI-MENTAL STATE EXA MINATION (M MSE) M axim u m Score Score 5 5 Orientation What is the (day of week) (day of month) (month) (year) (season)? Where are we: (state) (county) (town) (facility) (floor)?
ALZHEIMER S DISEASE FACTOIDS & STATISTICS
ALZHEIMER S DISEASE FACTOIDS & STATISTICS ~ 4 million affected in US alone 6-8% if 65+ years old, 30-50% if 80+ By 2030, in US >65 million people >65+ (---> ~14 million with AD) AD is one of the top 10
MINI MENTAL STATE EXAM
MINI MENTAL STATE EXAM ID NUMBER: FORM CODE: M M E DATE: 06/01/2011 Version 2.0 ADMINISTRATIVE INFORMATION 0a. Completion Date: / / 0b. Staff ID: Month Day Year Materials: Black pen, pencil, wrist watch,
WHAT IS DEMENTIA? An acquired syndrome of decline in memory and other cognitive functions sufficient to affect daily life in an alert patient
DEMENTIA WHAT IS DEMENTIA? An acquired syndrome of decline in memory and other cognitive functions sufficient to affect daily life in an alert patient Progressive and disabling Not an inherent aspect of
BHIVA Best Practice Management Session
BHIVA Best Practice Management Session CNS (The brain) - I keep forgetting things DEMENTIA DIAGNOSIS, CLASSIFICATION AND INVESTIGATIONS Paul Holmes Consultant Neurologist Guy s and St Thomas Hospitals
Cognitive Assessment. Part Two: Assessing Capacity, Beyond The Basics. Using Information To Make Decisions (Appreciating) What s s The Correct Method?
AUTONOMY, CAPACITY AND UNDUE INFLUENCE: KEMP Page 1 of 9 Part Two: Assessing Capacity, Beyond The Basics Cognitive Assessment Bryan Kemp, Ph. D. Center of Excellence in Elder Abuse and Neglect UC Irvine
Delirium & Dementia. Nicholas J. Silvestri, MD
Delirium & Dementia Nicholas J. Silvestri, MD Outline Delirium vs. Dementia Neural pathways relating to consciousness Encephalopathy Stupor Coma Dementia Delirium vs. Dementia Delirium Abrupt onset Lasts
Alzheimer s Disease without Dementia
Alzheimer s Disease without Dementia Dr Emer MacSweeney CEO & Consultant Neuroradiologist Re:Cognition Health London Osteopathic Society 13 September 2016 Early diagnosis of Alzheimer s Disease How and
Alzheimer s Disease. Pathophysiology: Alzheimer s disease (AD) is a progressive dementia affecting cognition, behavior,
2 Alzheimer s Disease Alzheimer s disease (AD) is a progressive dementia affecting cognition, behavior, and functional status with no known cause or cure. Patients eventually lose cognitive, analytical,
Dementia and Alzheimer s disease
Since 1960 Medicine Korat โรงพยาบาลมหาราชนครราชส มา Dementia and Alzheimer s disease Concise Reviews PAWUT MEKAWICHAI MD DEPARTMENT of MEDICINE MAHARAT NAKHON RATCHASIMA HOSPITAL 1 Prevalence Increase
Alzheimer's disease (AD), also known as Senile Dementia of the Alzheimer Type (SDAT) or simply Alzheimer s is the most common form of dementia.
CHAPTER 3 Alzheimer's disease (AD), also known as Senile Dementia of the Alzheimer Type (SDAT) or simply Alzheimer s is the most common form of dementia. This incurable, degenerative, terminal disease
Common Forms of Dementia Handout Package
Common Forms of Dementia Handout Package Common Forms of Dementia 1 Learning Objectives As a result of working through this module, you should be better able to: 1. Describe clinical features of 4 major
New life Collage of nursing Karachi
New life Collage of nursing Karachi Presenter: Zafar ali shah Faculty: Raja khatri Subject: Pathophysiology Topic :Alzheimer s Disease Post RN BScN semester 2 nd Objective Define Alzheimer s Describe pathophysiology
Dementia. Stephen S. Flitman, MD Medical Director 21st Century Neurology
Dementia Stephen S. Flitman, MD Medical Director 21st Century Neurology www.neurozone.org Dementia is a syndrome Progressive memory loss, plus Progressive loss of one or more cognitive functions: Language
I do not have any disclosures
Alzheimer s Disease: Update on Research, Treatment & Care Clinicopathological Classifications of FTD and Related Disorders Keith A. Josephs, MST, MD, MS Associate Professor & Consultant of Neurology Mayo
Assessing and Managing the Patient with Cognitive Decline
Assessing and Managing the Patient with Cognitive Decline Center of Excellence For Alzheimer s Disease for State of NY Capital Region Alzheimer s Center of Albany Medical Center Earl A. Zimmerman, MD Professor
Diagnosis and Treatment of Alzhiemer s Disease
Diagnosis and Treatment of Alzhiemer s Disease Roy Yaari, MD, MAS Director, Memory Disorders Clinic, Banner Alzheimer s Institute 602-839-6900 Outline Introduction Alzheimer s disease (AD)Guidelines -revised
The ABCs of Dementia Diagnosis
The ABCs of Dementia Diagnosis Dr. Robin Heinrichs, Ph.D., ABPP Board Certified Clinical Neuropsychologist Associate Professor, Psychiatry & Behavioral Sciences Director of Neuropsychology Training What
Dementia Prepared by: Joanne Leung Psychiatry Resident, University of Toronto
Dementia Prepared by: Joanne Leung Psychiatry Resident, University of Toronto Dementias are acquired neurodegenerative disorders involving a syndrome of cognitive impairment accompanied with social and
Improving diagnosis of Alzheimer s disease and lewy body dementia. Brain TLC October 2018
Improving diagnosis of Alzheimer s disease and lewy body dementia Brain TLC October 2018 Plan for this discussion: Introduction to AD and LBD Why do we need to improve diagnosis? What progress has been
ALZHEIMER S DISEASE. Mary-Letitia Timiras M.D. Overlook Hospital Summit, New Jersey
ALZHEIMER S DISEASE Mary-Letitia Timiras M.D. Overlook Hospital Summit, New Jersey Topics Covered Demography Clinical manifestations Pathophysiology Diagnosis Treatment Future trends Prevalence and Impact
DEMENTIA? 45 Million. What is. WHAT IS DEMENTIA Dementia is a disturbance in a group of mental processes including: 70% Dementia is not a disease
What is PRESENTS DEMENTIA? WHAT IS DEMENTIA Dementia is a disturbance in a group of mental processes including: Memory Reasoning Planning Learning Attention Language Perception Behavior AS OF 2013 There
Clinical Diagnosis. Step 1: Dementia or not? Diagnostic criteria for dementia (DSM-IV)
Step 1: Dementia or not? Diagnostic criteria for dementia (DSM-IV) A. The development of multiple cognitive deficits manifested by both 1 and 2 1 1. Memory impairment 2. One (or more) of the following
AGED SPECIFIC ASSESSMENT TOOLS. Anna Ciotta Senior Clinical Neuropsychologist Peninsula Mental Health Services
AGED SPECIFIC ASSESSMENT TOOLS Anna Ciotta Senior Clinical Neuropsychologist Peninsula Mental Health Services Issues in assessing the Elderly Association between biological, psychological, social and cultural
DEMENTIA IN PARKINSON`S DISEASE. DR C PADMAKUMAR MD FRACP FRCP(Edin) Director-Parkinson`s Disease Service for the Older Person HNELHD
DEMENTIA IN PARKINSON`S DISEASE DR C PADMAKUMAR MD FRACP FRCP(Edin) Director-Parkinson`s Disease Service for the Older Person HNELHD DEMENTIA IN PD The concept of Non Motor Symptoms in PD Dementia in Parkinson`s
7/3/2013 ABNORMAL PSYCHOLOGY SEVENTH EDITION CHAPTER FOURTEEN CHAPTER OUTLINE. Dementia, Delirium, and Amnestic Disorders. Oltmanns and Emery
ABNORMAL PSYCHOLOGY SEVENTH EDITION Oltmanns and Emery PowerPoint Presentations Prepared by: Ashlea R. Smith, Ph.D. This multimedia and its contents are protected under copyright law. The following are
DISCLOSURES. Objectives. THE EPIDEMIC of 21 st Century. Clinical Assessment of Cognition: New & Emerging Tools for Diagnosing Dementia NONE TO REPORT
Clinical Assessment of Cognition: New & Emerging Tools for Diagnosing Dementia DISCLOSURES NONE TO REPORT Freddi Segal Gidan, PA, PhD USC Keck School of Medicine Rancho/USC California Alzheimers Disease
What if it s not Alzheimer s? Update on Lewy body dementia and frontotemporal dementia
What if it s not Alzheimer s? Update on Lewy body dementia and frontotemporal dementia Dementia: broad term for any acquired brain condition impairing mental function such that ADLs are impaired. Includes:
Enhancing mental capacity. Dr Sarah JL Edwards Senior Lecturer in Research Governance
Enhancing mental capacity Dr Sarah JL Edwards Senior Lecturer in Research Governance Contents Patients understanding medical information Assessing mental capacity Treating those without capacity Informational
Name at birth. Address. MMSE: CASE: Cognigram. MMSE (Folstein and coll., 1975) Temporal Orientation Day: Date: Month: Season: Year: /5
CASE Cognitive Assessment Scale for the Elderly Daniel Geneau - Daniel Taillefer Institution Examiner Date of exam Age Education Date of birth Room File No y m d Name at birth Usual name or spouse name
DEMENTIA 101: WHAT IS HAPPENING IN THE BRAIN? Philip L. Rambo, PhD
DEMENTIA 101: WHAT IS HAPPENING IN THE BRAIN? Philip L. Rambo, PhD OBJECTIVES Terminology/Dementia Basics Most Common Types Defining features Neuro-anatomical/pathological underpinnings Neuro-cognitive
Memory Disorders. 1. Episodic: memory for time and places. 2. Semantic: memory for facts and knowledge (language, numbers, etc).
I. Types of memory: A. Declarative memory: Memory Disorders 1. Episodic: memory for time and places. 2. Semantic: memory for facts and knowledge (language, numbers, etc). B. Procedural memory: - examples:
Alzheimer s disease dementia: a neuropsychological approach
Alzheimer s disease dementia: a neuropsychological approach Dr. Roberta Biundo, PhD Neuropsychology Coordinator at Parkinson s disease and movement disorders unit of San Camillo rehabilitation hospital
The Spectrum of Lewy Body Disease: Dementia with Lewy Bodies and Parkinson's Disease Dementia
Disclosures Research support, Parkinson Society Canada, Canadian Institutes of Health Research, Ministry of Economic Development and Innovation, Teva Novartis clinical trial, Principal Investigator CME
FACTORS AFFECTING CAPACITY
FACTORS AFFECTING CAPACITY Psychosocial Factors Affecting Capacity Psychosocial factors include one s surroundings, way of life & things that affect relationships between the adult and their environment.
Platelet Amyloid Precursor Protein Processing: A Biomarker for Alzheimer s Disease.
Platelet Amyloid Precursor Protein Processing: A Biomarker for Alzheimer s Disease. Roger N. Rosenberg, MD Alzheimer s Disease Center University of Texas Southwestern Medical Center at Dallas Disclosures:
CSF Aβ1-42 predicts cognitive impairment in de novo PD patients
CSF Aβ1-42 predicts cognitive impairment in de novo PD patients Mark Terrelonge MPH *1, Karen Marder MD MPH 1, Daniel Weintraub MD 2, Roy Alcalay MD MS 1 1 Columbia University Department of Neurology 2
FRONTOTEMPORAL DEGENERATION: OVERVIEW, TRENDS AND DEVELOPMENTS
FRONTOTEMPORAL DEGENERATION: OVERVIEW, TRENDS AND DEVELOPMENTS Norman L. Foster, M.D. Director, Center for Alzheimer s Care, Imaging and Research Chief, Division of Cognitive Neurology, Department of Neurology
Clinicopathologic and genetic aspects of hippocampal sclerosis. Dennis W. Dickson, MD Mayo Clinic, Jacksonville, Florida USA
Clinicopathologic and genetic aspects of hippocampal sclerosis Dennis W. Dickson, MD Mayo Clinic, Jacksonville, Florida USA The hippocampus in health & disease A major structure of the medial temporal
Sharon Shacham, Ph.D. ICAD, July 29th, 2008 NASDAQ: EPIX
Stimulation of Serotonin Type 4 Receptors Leads to Increases in Alpha-Secreatase Activity and sappalpha: Potential for Disease Modification in Alzheimer's Disease Sharon Shacham, Ph.D. ICAD, July 29th,
MENTAL DISORDERS. Mental Health VS Psychiatry. Mental Health VS Psychiatry. Community Mental Health in Elderly and Geriatric Psychiatry.
Mental Health VS Psychiatry Community Mental Health in Elderly and Geriatric Psychiatry THITIPHAN THANEERAT, M.D., M.S. Director of Nakhonsawan Rajanagarindra Psychiatric Hospital Mental Health VS Psychiatry
The Marmoset Monkey as Model for Neurological Disorders
The Marmoset Monkey as Model for Neurological Disorders Jan Langermans and Ingrid Philippens From Laboratory to Clinic Disease models neuroscience: Parkinson, Sleep, Stress, Alzheimer, MS MS Models: rhmog
Cognitive Screening in Risk Assessment. Geoffrey Tremont, Ph.D. Rhode Island Hospital & Alpert Medical School of Brown University.
Cognitive Screening in Risk Assessment Geoffrey Tremont, Ph.D. Rhode Island Hospital & Alpert Medical School of Brown University Outline of Talk Definition of Dementia and MCI Incidence and Prevalence
CASE 49. What type of memory is available for conscious retrieval? Which part of the brain stores semantic (factual) memories?
CASE 49 A 43-year-old woman is brought to her primary care physician by her family because of concerns about her forgetfulness. The patient has a history of Down syndrome but no other medical problems.
FTD basics! Etienne de Villers-Sidani, MD!
FTD basics! Etienne de Villers-Sidani, MD! Frontotemporal lobar degeneration (FTLD) comprises 3 clinical syndromes! Frontotemporal dementia (behavioral variant FTD)! Semantic dementia (temporal variant
Subject Index. Band of Giacomini 22 Benton Visual Retention Test 66 68
Subject Index Adams, R.D. 4 Addenbrooke s Cognitive Examination 101 Alzheimer s disease clinical assessment histological imaging 104 neuroimaging 101 104 neuropsychological assessment 101 clinical presentation
Neuropathology of Neurodegenerative Disorders Prof. Jillian Kril
Neurodegenerative disorders to be discussed Alzheimer s disease Lewy body diseases Frontotemporal dementia and other tauopathies Huntington s disease Motor Neuron Disease 2 Neuropathology of neurodegeneration
02/04/2015. The structure of the talk. Dementia as a motor disorder. Movement, cognition & behaviour. Example 1. Example 2
The th Annual Memory Clinic Conference Dublin, Trinity College, 27 March 1 The structure of the talk Dementia as a motor disorder Thomas H. Bak Human Cognitive Neuroscience & Centre for Clinical Brain
Human Neurology 3-Plex A
Human Neurology 3-Plex A SUMMARY AND EXPLANATION OF THE TEST The Human N3PA assay is a digital immunoassay for the quantitative determination of total Tau, Aβ42, and Aβ40 in human plasma and CSF. Determination
Alzheimer s Disease. Clinical characteristics of late-onset Alzheimer s disease (LOAD) A/Prof David Darby
Alzheimer s Disease Clinical characteristics of late-onset Alzheimer s disease (LOAD) A/Prof David Darby Florey Institute of Neuroscience and Mental Health 28-6-2013 The burden of late-onset Alzheimer
Dementia. Amber Eker, MD. Assistant Professor Near East University Department of Neurology
Dementia Amber Eker, MD Assistant Professor Near East University Department of Neurology Dementia An acquired syndrome consisting of a decline in memory and other cognitive functions Impairment in social
Imaging of Alzheimer s Disease: State of the Art
July 2015 Imaging of Alzheimer s Disease: State of the Art Neir Eshel, Harvard Medical School Year IV Outline Our patient Definition of dementia Alzheimer s disease Epidemiology Diagnosis Stages of progression
Neuro degenerative PET image from FDG, amyloid to Tau
Neuro degenerative PET image from FDG, amyloid to Tau Kun Ju Lin ( ) MD, Ph.D Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital ( ) Department of Medical Imaging
Montreal Cognitive Assessment (MoCA) Overview for Best Practice in Stroke and Complex Neurological Conditions March 2013
Montreal Cognitive Assessment (MoCA) Overview for Best Practice in Stroke and Complex Neurological Conditions March 2013 1 MoCA 2 Overview of the MoCA Takes approximately 15 minutes to administer Requires
Caring Sheet #11: Alzheimer s Disease:
CARING SHEETS: Caring Sheet #11: Alzheimer s Disease: A Summary of Information and Intervention Suggestions with an Emphasis on Cognition By Shelly E. Weaverdyck, PhD Introduction This caring sheet focuses
DEMENTIA, THE BRAIN AND HOW IT WORKS AND WHY YOU MATTER
OVERCOMING THE CHALLENGES OF MANAGING CHRONIC DISEASES IN PERSONS WITH DEMENTIA DEMENTIA, THE BRAIN AND HOW IT WORKS AND WHY YOU MATTER LEARNING OBJECTIVES Be familiar with the diagnostic criteria for
Diabetes Mellitus and Dementia. Andrea Shelton & Adena Zadourian
Diabetes Mellitus and Dementia Andrea Shelton & Adena Zadourian Abstract Diabetes mellitus increases the risk for developing dementia...but there is inconsistency with the subtypes of dementia Diabetes
Dementia. Jeanette Norden, Ph.D. Professor Emerita Vanderbilt University School of Medicine
Dementia Jeanette Norden, Ph.D. Professor Emerita Vanderbilt University School of Medicine What is Dementia? Dementia is a general term referring to a decline in cognitive/mental functioning; this decline
RECOGNITION AND MANAGEMENT OF DEMENTIA IN THE ACUTE CARE SETTING
RECOGNITION AND MANAGEMENT OF DEMENTIA IN THE ACUTE CARE SETTING Alex Hishaw, MD Department of Neurology University of Arizona Objectives: Recognize the impact of history and presentation on the diagnosis
NEUROPSYCHOMETRIC TESTS
NEUROPSYCHOMETRIC TESTS CAMCOG It is the Cognitive section of Cambridge Examination for Mental Disorders of the Elderly (CAMDEX) The measure assesses orientation, language, memory, praxis, attention, abstract
MENTAL STATE EXAMINATION FAHAD ALOSAIMI MBBS, SSC- PSYCH CONSULTATION LIAISON PSYCHIATRIST KING SAUD UNIVERSITY
MENTAL STATE EXAMINATION FAHAD ALOSAIMI MBBS, SSC- PSYCH CONSULTATION LIAISON PSYCHIATRIST KING SAUD UNIVERSITY The mental status examination( MSE) MSE is a cross-sectional, systemic documentation of the
Alzheimer's Disease A mind in darkness awaiting the drink of a gentle color.
Alzheimer's Disease A mind in darkness awaiting the drink of a gentle color. Mary ET Boyle, Ph. D. Department of Cognitive Science UCSD Gabriel García Márquez One Hundred Years of Solitude Alois Alzheimer
Biomarkers for Alzheimer s disease
Biomarkers for Alzheimer s Disease Henrik Zetterberg, MD, PhD Professor of Neurochemistry The Sahlgrenska Academy, University of Gothenburg 1 Alzheimer s disease 2 Neuropathological criteria for Alzheimer
Emerging CSF and serum biomarkers in atypical dementia. Laksanun Cheewakriengkrai, MD. Phramongkutklao Hospital March 7 th, 2018
Emerging CSF and serum biomarkers in atypical dementia Laksanun Cheewakriengkrai, MD. Phramongkutklao Hospital March 7 th, 2018 Biomarkers A characteristic that is objectively measured and evaluated as
TGF-ß1 pathway as a new pharmacological target for neuroprotection in AD. Filippo Caraci
Department of Clinical and Molecular Biomedicine Section of Pharmacology and Biochemistry Department of Educational Sciences University of Catania TGF-ß1 pathway as a new pharmacological target for neuroprotection
Comments to this discussion are invited on the Alzforum Webinar page. Who Should Use the New Diagnostic Guidelines? The Debate Continues
Comments to this discussion are invited on the Alzforum Webinar page. Who Should Use the New Diagnostic s? The Debate Continues Ever since new criteria came out for a research diagnosis of prodromal/preclinical
Tau Mechanism in Dementia
ADC Directors Meeting Saturday, April 12, 2008 Sheraton V Tau Mechanism in Dementia Lennart Mucke, M.D. Director, Gladstone Institute of Neurological Disease Joseph B. Martin Distinguished Professor Department
DEMENTIA 9/29/16. Introduction. Introduction. Signs and Symptom. Epidemiology. Dementia. Dr. Yotin Chinvarun M.D. Ph.D.
Introduction DEMENTIA Dr. Yotin Chinvarun M.D. Ph.D. Neurology, Pramongkutklao hospital In 1901 Auguste Deter, a woman in her early 50s, became 1 st person diagnosed with Alzheimer's disease, a form of
DEMENTIA. Szabolcs Szatmári. Tg. Mureş Marosvásárhely Romania 4/18/ :59 AM
DEMENTIA Szabolcs Szatmári Tg. Mureş Marosvásárhely Romania Dementia from Latin de- "apart, away" + mens (genitive mentis) "mind" MORE GRAY HAIR AND LESS GRAY MATTER Daryl R. Gress Cognitive decline
Alzheimer s Disease Update: From Treatment to Prevention
Alzheimer s Disease Update: From Treatment to Prevention Jeffrey M. Burns, MD Edward H. Hashinger Professor of Medicine Co-Director, KU Alzheimer s Disease Center Director, Clinical and Translational Science
First described by James Parkinson in his classic 1817 monograph, "An Essay on the Shaking Palsy"
Parkinson's Disease First described by James Parkinson in his classic 1817 monograph, "An Essay on the Shaking Palsy" Parkinson s disease (PD) is a neurological disorder characterized by a progressive
DEMENTIA and BPSD in PARKINSON'S DISEASE. DR. T. JOHNSON. NOVEMBER 2017.
DEMENTIA and BPSD in PARKINSON'S DISEASE. DR. T. JOHNSON. NOVEMBER 2017. Introduction. Parkinson's disease (PD) has been considered largely as a motor disorder. It has been increasingly recognized that
Palliative Approach to the Person with Advanced Dementia
Mid North Coast Rural Palliative Care Project Link Nurse Education 2004 Palliative Approach to the Person with Advanced Dementia Anne Sneesby CNC - ACAT To care for the dying is a very human opportunity
What is dementia? What is dementia?
What is dementia? What is dementia? What is dementia? Dementia is an umbrella term for a range of progressive conditions that affect the brain. There are over 200 subtypes of dementia, but the five most
#CHAIR2015. Miami, Florida. September 24 26, JW Marriott Miami. Sponsored by
#CHAIR2015 September 24 26, 2015 JW Marriott Miami Miami, Florida Sponsored by Case Challenge Workshop Alzheimer s Disease Anand Kumar, MD University of Illinois at Chicago, College of Medicine Chicago,
Objectives. RAIN Difficult Diagnosis 2014: A 75 year old woman with falls. Case History: First visit. Case History: First Visit
Objectives RAIN Difficult Diagnosis 2014: A 75 year old woman with falls Alexandra Nelson MD, PhD UCSF Memory and Aging Center/Gladstone Institute of Neurological Disease Recognize important clinical features
Overview. Case #1 4/20/2012. Neuropsychological assessment of older adults: what, when and why?
Neuropsychological assessment of older adults: what, when and why? Benjamin Mast, Ph.D. Associate Professor & Vice Chair, Psychological & Brain Sciences Associate Clinical Professor, Family & Geriatric
A break with reality. Hallucinations. Disorganized speech and thinking
Other Psychotic Disorders István Bitter 28 October 2009 Psychosis A break with reality Hallucinations Delusions Disorganized speech and thinking Psychosis Negative Symptoms blunted affect decreased motivation
What is dementia? What is dementia?
What is dementia? What is dementia? What is dementia? Dementia is an umbrella term for a range of progressive conditions that affect the brain. It has been identified that there are over 200 subtypes of
Behavioral Aspects of Parkinson s Disease
Behavioral Aspects of Parkinson s Disease Joseph H. Friedman, MD Director, Movement Disorders Program Butler Hospital Dept of Neurology Alpert Medical School of Brown University 1 Disclosures Drugs will
Stem Cells and the Study of Neurodegeneration. Tracy Young-Pearse, PhD September 12, 2014!
Stem Cells and the Study of Neurodegeneration Tracy Young-Pearse, PhD September 12, 2014! Techniques for studying mechanisms of neurological disease Animal models Human subjects Postmortem analyses, imaging
Neuroinflammation in preclinical AD: in vivo evidence
Neuroinflammation in preclinical AD: in vivo evidence Barbara Bendlin, PhD Assistant Professor UW-Madison Dept. of Medicine, Geriatrics bbb@medicine.wisc.edu Overview Background Preclinical effects of
CHAPTER 15: NEUROCOGNITIVE DISORDERS KEY TERMS. Acetylcholine A neurotransmitter that appears to be involved in learning and memory.
CHAPTER 15: NEUROCOGNITIVE DISORDERS KEY TERMS Acetylcholine A neurotransmitter that appears to be involved in learning and memory. Adult Memory and Information Processing Battery (AMIPB) A neuropsychological
CSF: Lessons From Other Diseases
CSF: Lessons From Other Diseases Consultant: AbbVie, Accordant, Acorda, Bayer, Biogen, Genentech/Roche, Genzyme/Sanofi, Novartis, Serono, Teva Research: Actelion, Novartis, Opexa Alzheimer s Progressive
Mild Cognitive Impairment (MCI)
October 19, 2018 Mild Cognitive Impairment (MCI) Yonas E. Geda, MD, MSc Professor of Neurology and Psychiatry Consultant, Departments of Psychiatry & Psychology, and Neurology Mayo Clinic College of Medicine
Assessing cognitive function after stroke. Glyn Humphreys
Assessing cognitive function after stroke Glyn Humphreys (glyn.humphreys@psy.ox.ac.uk) Write down 3 important cognitive problems after stroke What things are important to detect? OCS Impairment incidences
Outline. Facts and figures Action plans Early / correct diagnosis Conclusions
Outline Facts and figures Action plans Early / correct diagnosis Conclusions Dementia: the greatest chalenge. Time to act now Philip Scheltens Professor of Neurology VU University Medical Center Amsterdam
Confronting the Clinical Challenges of Frontotemporal Dementia
Confronting the Clinical Challenges of Frontotemporal Dementia A look at FTD s symptoms, pathophysiology, subtypes, as well as the latest from imaging studies. By Zac Haughn, Senior Associate Editor Ask
Delirium, Dementia, and Amnestic Disorders. Dr.Al-Azzam 1
Delirium, Dementia, and Amnestic Disorders Dr.Al-Azzam 1 Introduction Disorders in which a clinically significant deficit in cognition or memory exists The number of people with these disorders is growing
Chronic Traumatic Encephalopathy Provider and Parent Essentials
Chronic Traumatic Encephalopathy Provider and Parent Essentials Concussion Global Cast July 30, 2014 John Lockhart, MD Seattle Children s Hospital Chronic Traumatic Encephaly (CTE) Working Definition Chronic
Non Alzheimer Dementias
Non Alzheimer Dementias Randolph B Schiffer Department of Neuropsychiatry and Behavioral Science Texas Tech University Health Sciences Center 9/11/2007 Statement of Financial Disclosure Randolph B Schiffer,,
Dementia. Dr Maria Foundas Consultant Physician. Training support Skills development Competency Assessment Scholarships Education
Dementia Dr Maria Foundas Consultant Physician Training support Skills development Competency Assessment Scholarships Education Preamble and disclaimer These slides are made available by the Western Australian
Overview. Overview. Parkinson s disease. Secondary Parkinsonism. Parkinsonism: Motor symptoms associated with impairment in basal ganglia circuits
Overview Overview Parkinsonism: Motor symptoms associated with impairment in basal ganglia circuits The differential diagnosis of Parkinson s disease Primary vs. Secondary Parkinsonism Proteinopathies:
9.01 Introduction to Neuroscience Fall 2007
MIT OpenCourseWare http://ocw.mit.edu 9.01 Introduction to Neuroscience Fall 2007 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms. 9.01 Recitation (R02)