Neuroendocrinology of Hypoactive Sexual Desire Disorder (HSDD): The Basics
|
|
- Gabriella Powell
- 5 years ago
- Views:
Transcription
1 Neuroendocrinology of Hypoactive Sexual Desire Disorder (HSDD): The Basics James A. Simon, MD, CCD, NCMP, IF, FACOG Clinical Professor Department of Ob/Gyn George Washington University Washington, DC Medical Director Women s Health & Research Consultants Washington, DC James A Simon, MD,
2 Disclosures 2016 Owner/Board of Directors: James A. Simon, MD, PC; Women s Health & Research Consultants Advisory Board/Consultant: Dr. James A. Simon has served (within the last year) or is currently serving as a consultant to or on the advisory boards of: AbbVie, Inc. (North Chicago, IL), Allergan, Plc (Parsippany, NJ), AMAG Pharmaceuticals, Inc. (Waltham, MA), Amgen Inc. (Thousand Oaks, CA), Apotex, Inc. (Toronto, Canada), Ascend Therapeutics (Herndon, VA), Azure Biotech, Inc. (River Vale, NJ), JDS Therapeutics, LLC (Purchase, NY), Merck & Co., Inc. (Whitehouse Station, NJ), Millendo Therapeutics, Inc. (Ann Arbor, MI), Noven Pharmaceuticals, Inc. (New York, NY), Novo Nordisk (Bagsvrerd, Denmark), Nuelle, Inc. (Mountain View, CA), Perrigo Company, PLC (Dublin, Ireland), Radius Health, Inc. (Waltham, MA), Regeneron Pharmaceuticals, Inc. (Tarrytown, NY), Roivant Sciences, Inc. (New York, NY), Sanofi S.A. (Paris, France), Sebela Pharmaceuticals, Inc. (Roswell, GA), Sermonix Pharmaceuticals, Inc. (Columbus, OH), Shionogi Inc. (Florham Park, NJ), Sprout Pharmaceuticals (Raleigh, NC), Symbiotec Pharmalab (Indore, India), TherapeuticsMD (Boca Raton, FL), Valeant Pharmaceuticals (Laval, Canada). Speaker: He has also served (within the last year) or is currently serving on the speaker s bureaus of: Amgen Inc. (Thousand Oaks, CA), Eisai, Inc. (Woodcliff Lake, NJ), Merck (Whitehouse Station, NJ), Noven Pharmaceuticals, Inc. (New York, NY), Novo Nordisk (Bagsvrerd, Denmark), Shionogi Inc. (Florham Park, NJ), Valeant Pharmaceuticals (Laval, Canada). Grants/Research: In the last year he has received or is currently receiving grant/research support from: AbbVie, Inc. (North Chicago, IL), Actavis, PLC. (Dublin, Ireland), Agile Therapeutics (Princeton, NJ), Bayer Healthcare LLC., (Tarrytown, NY), GlaxoSmithKline (Brentford, United Kingdom), New England Research Institute, Inc. (Watertown, MA), Novo Nordisk (Bagsvrerd, Denmark), Palatin Technologies (Cranbury, NJ), Symbio Research, Inc. (Port Jefferson, NY), TherapeuticsMD (Boca Raton, FL). Patent and Trademark Holder: U.S. Patent: 4,816,257, March 28, 1989: "Method for Producing an In Vivo Environment Suitable for Human Embryo Transplant.", U.S. Trademark: Reg. No. 3,446,895, Registered June 10, 2008: You talk I ll Listen. We ll Plan Together., U.S. Trademark: Reg. No. 3,676,269, Registered September 1, 2009: U.S. Trademark: Reg. No. 3,760,080, Registered March 16, 2010: Women s Health & Research Consultants & Design, U.S. Trademark Serial No.:86-714,153. DR. SIMON SAYS Registered February 2, Stock Shareholder and/or other Financial Support: Dr. Simon is a stockholder (direct purchase) in Sermonix Pharmaceuticals (Columbus, OH).
3 Learning Objectives: Upon completion of this lecture participants should: Have a basic understanding of the neuroendocrinology of HSDD. Appreciate the potential sites of therapeutic intervention based on our current understanding of that neuroendocrinology.
4 The Sexual Response Cycle Modified by Kaplan (1974) and Georgiadis et al. (2012) Kaplan HS The new sex therapy. New York: Brunner/Mazel Georgiadis JR, Kringelbach ML, Pfaus JG. Nat Rev Urol 2012;9:
5 Neurobiological & Behavioral Elements of Sexual Response Georgiadis JR, Kringelbach ML, Pfaus JG. Nat Rev Urol 2012;9:
6 Processing of Sexual Cues & Stimuli Integration of Signals
7 Prefrontal Cortex Controls Executive Function Pfaus JG Pathways of sexual desire. J Sex Med 2009;6:
8 Evolutionary Imperative: Peak Desire during Ovulation Pfaus et al. (2015) Physiology of Reproduction (Vol 2) Academic Press: NY; Stanislaw, Rice (1988) Arch Sex Behav, 17, ; Wallen (1982) Science, 217,
9 Central Regulation of Desire/Arousal Estrogen Progesterone (+) Adapted from Clayton & Hamilton. Female Sexual Dysfunction. Obstet Gynecol Clin North Am 2009; 36: (-) Serotonin
10 Neural Pathways Regulating Sexual Desire in the Brain: Integration of Excitation and Inhibition Excitatory Inhibitory Goldstein I, Kim NN, Clayton AH et al: Hypoactive Sexual Desire Disorder: International Society for the Study of Women s Sexual Health Expert Consensus Panel Review. Mayo Clinic Proceedings, in press.
11 Glutamate: 2-Way Communicator in the Brain
12 Selective Regulation of Glutamate Neurons by 5-HT Glutamate neurons can be selectively activated or inhibited due to different locations and types of 5-HT receptors on glutamate neurons 5-HT 1A (inhibit glu neuron) 5-HT 2A (activate glu neuron) Stahl SM. CNS Spectrums 2015;20:1-6. Stahl et al. J Sex Med 2011; 8:
13 Glutamate Neuron Activity May Be Elevated in HSDD Preferential stimulation of 5-HT 2A receptors LOW DESIRE Low DA & NE High 5-HT 5-HT 2A (activation) Increased Glutamate Release Stahl SM. CNS Spectrums 2015;20:1-6. Stahl et al. J Sex Med 2011; 8:
14 Flibanserin Appears to Work Through This Glutamate Network From: Stahl SM, Sommer B, and Allers KA. Multifunctional pharmacology of flibanserin: Possible mechanism of therapeutic action in hypoactive sexual desire disorder. J Sex Med 2011;8:15 27.
15 Neural Plasticity: Animal Studies Adaptive changes in brain structure and function in response to: Stress External environment Hormonal milieu (estrogens, in particular) Associated with changes in sexual response Desire & arousal Most data from rodent studies (mating, pregnancy & postmenopausal models)
16 Neural Plasticity: Estrogens and Neurite Growth non-estrous Lumbosacral motor neurons estrous Van der Horst & Holstege. J Neurosci 1997; 17: E 2 membrane excitability (rapid effects) Similar changes occur with repetitive neural activity (learning/ memory) Neurons that fire together wire together Donald Hebbs
17 Patterns of Cortical Activation and Deactivation by Erotic Visual Cues (PET Scan) Decreased activation, observed primarily in the left hemisphere, is shown in red and increased activation, observed primarily in the right hemisphere, is shown in green. Minimal deactivation was observed in the right hemisphere and minimal activation was observed in the left hemisphere. Goldstein I, Kim NN, Clayton AH et al: Hypoactive Sexual Desire Disorder: International Society for the Study of Women s Sexual Health Expert Consensus Panel Review. Mayo Clinic Proceedings, in press. MRI adapted from Holstege G, How the emotional motor system controls pelvic organs, J Sex Med, in press.
18 Differences in Brain Structure in Women with HSDD Example of Experience-Based Neuroplasticity? Decreased Gray Matter Increased White Matter Alterations in: Salience attribution to sexual stimuli Perception of bodily sexual responses Attentional mechanisms Lower orgasmic function Decreased axonal function? Increased inhibitory circuitry? Bloemers et al. J Sex Med 2014; 11:
19 Current Treatments for HSDD and Their Hypothetical Mechanism(s) of Action
20 What Is The Neuroendocrinology of HSDD? Goldstein I, Kim NN, Clayton AH, DeRogatis LR, Giraldi A, Parish SJ, Pfaus J, Simon JA, Kingsberg SA, Meston C, Stahl SM, Wallen K, Worsley R. Hypoactive Sexual Desire Disorder: International Society for the Study of Women s Sexual Health (ISSWSH) Expert Consensus Panel Review. Mayo Clin Proc (in press)
21 Summary and Conclusion Sexual desire depends on the activation of neurochemical systems for sexual excitation by erotic cues, driven most directly by dopamine and norepinephrine. Sexual inhibition is a normal function of satiety, driven by brain opioid, serotonin, and endocannabinoid systems. HSDD may occur if sexual excitation is too weak, or sexual inhibition too strong, or a combination of both. Lack of sexual desire can also occur as an adaptation of neural systems to a chronic lack of sexual pleasure (i.e. a learned behavior use it or lose it ).
Psykiatri PCK/Sexologisk Klinik Medication for Female Sexual Dysfunction - where are we?
Medication for Female Sexual Dysfunction - where are we? Annamaria Giraldi, Professor, MD, PHD Sexological Clinic Copenhagen, Denmark Disclosures Eli Lilly - lecturer Boehringer advisory board Pfizer -
More information9/30/2016. Data and Women s Preferences Should Inform the Treatment of Hypoactive Sexual Desire Disorder: The Case for Pharmacologic Agents
Data and Women s Preferences Should Inform the Treatment of Hypoactive Sexual Desire Disorder: The Case for Pharmacologic Agents Sources of Evidence for Physiological Mechanisms Modulating Sexual Desire
More informationEstradiol (Estrogens) Disclosures /20/ :11:34 PM. Metabolism of Oral Estradiol 17β
A Conversation About Hormone Therapy: Is There an Appropriate Dose, Route, and Duration of Use? Session 4Special Areas of Concern The Impact of Route of Administration (Oral, Transdermal, Vaginal) and
More informationSpring Course. International Society for the Study of Women's Sexual Health Washington, DC - USA.
ISSWSH, Inc. International Society for the Study of Women's Sexual Health Spring Course Washington, DC - USA Grand Hyatt Washington April 10-12, 2015 WWW.ISSWSHCOURSE.ORG Follow us on Twitter @ISSWSH ISSWSH
More informationPostmenopausal vulvar and vaginal atrophy (VVA) is
Menopause: The Journal of The North American Menopause Society Vol. 24, No. 4, pp. 409-416 DOI: 10.1097/GME.0000000000000786 ß 2016 The Author(s). Published by Wolters Kluwer Health, Inc., on behalf of
More informationFlibanserin is indicated for the treatment of acquired,
JOURNAL OF WOMEN S HEALTH Volume 26, Number 11, 2017 Mary Ann Liebert, Inc. DOI: 10.1089/jwh.2016.6230 Effect of Flibanserin Treatment on Body Weight in Premenopausal and Postmenopausal Women with Hypoactive
More informationDisclosures. REPLENISH Trial: Objective and Design. Background Use of compounded bioidentical hormone therapy (CBHT) has become highly prevalent
17β Estradiol/Progesterone in a Single Oral Softgel Capsule (TX 001HR) Significantly Reduced Moderate to Severe Vasomotor Symptoms without Endometrial Hyperplasia Disclosures Research support: Actavis,
More informationColumbia University Medical Center, New York, NY 2. Clinical Research Center, Eastern Virginia Medical School, Norfolk, VA 3
17β-Estradiol/Progesterone in a Single Oral Softgel Capsule (TX-001HR) Significantly Reduced Moderate-to-Severe Vasomotor Symptoms without Endometrial Hyperplasia Rogerio A Lobo, MD 1 ; David F Archer,
More informationHypoactive Sexual Desire Disorder: Advances in Diagnosis and Treatment
Transcript Details This is a transcript of a continuing medical education (CME) activity accessible on the ReachMD network. Additional media formats for the activity and full activity details (including
More informationEffects of TX-001HR on Uterine Bleeding Rates in Menopausal Women with Vasomotor Symptoms
Effects of TX-001HR on Uterine Bleeding Rates in Menopausal Women with Vasomotor Symptoms Photo (compulsory) Steven R Goldstein, MD 1 ; Ginger D Constantine, MD 2 ; David F Archer, MD 3 ; James H Pickar,
More informationUpdating the Female Nomenclature: ICSM, ISSWSH, and ICD-11 Classification. Sharon J. Parish, MD, IF, NCMP 2017 Annual Scientific Program May 12, 2017
Updating the Female Nomenclature: ICSM, ISSWSH, and ICD-11 Classification Sharon J. Parish, MD, IF, NCMP 2017 Annual Scientific Program May 12, 2017 Disclosures Advisory Board Palatin, Valeant Speaker
More informationSouthern California Center for Sexual Health and Survivorship Medicine Inc, Newport Beach, CA 3
The WISDOM survey: Physicians Level of Comfort Prescribing Treatment for Vulvar and Vaginal Atrophy (VVA) Symptoms in Women with a Predisposition or History of Breast Cancer Lisa Larkin, MD 1 ; Michael
More informationAcetylcholine (ACh) Action potential. Agonists. Drugs that enhance the actions of neurotransmitters.
Acetylcholine (ACh) The neurotransmitter responsible for motor control at the junction between nerves and muscles; also involved in mental processes such as learning, memory, sleeping, and dreaming. (See
More informationPatient and Physician Perspectives on Administration of the PCSK9 Monoclonal Antibody Alirocumab, an Injectable Medication to Lower LDL-C Levels
Patient and Physician Perspectives on Administration of the PCSK9 Monoclonal Antibody Alirocumab, an Injectable Medication to Lower LDL-C Levels Bertrand Cariou, 1 Maja Bujas-Bobanovic, 2 Michael J Louie,
More informationThe Three Pearls DOSE FUNCTION MOTIVATION
The Three Pearls DOSE FUNCTION MOTIVATION Barriers to Evidence-Based Neurorehabilitation No placebo pill for training therapy Blinded studies often impossible Outcome measures for movement, language, and
More informationThis article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and
This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution
More informationExpanding Mindfulness as a Core Treatment Skill for Men and Women With Cognitive Deficits Thomas G. Beckers BS, LADC Vinland Center
Expanding Mindfulness as a Core Treatment Skill for Men and Women With Cognitive Deficits Thomas G. Beckers BS, LADC Vinland Center What Are We Going to Cover? To gain understanding of the nature of addiction
More informationEvaluation of Systemic Effects of a Vaginal Estradiol Softgel Capsule Insert (TX-004HR) in Menopausal Women with Moderate to Severe Dyspareunia
Evaluation of Systemic Effects of a Vaginal Estradiol Softgel Capsule Insert (TX-4HR) in Menopausal Women with Moderate to Severe Dyspareunia Lisa Larkin, MD 1 ; Andrew M Kaunitz, MD 2 ; James Liu, MD
More informationPhoto (compulsory) Columbia University Medical Center, New York, NY 2. University of Southern California, Keck School of Medicine, Los Angeles, CA 3
Progesterone bioavailability for preventing endometrial stimulation with a continuous-combined regimen of TX-001HR (oral estradiol and micronized progesterone capsules) Photo (compulsory) Rogerio A. Lobo,
More informationSexual dysfunction: Is it all about hormones?
Sexual dysfunction: Is it all about hormones? Angelica Lindén Hirschberg, MD, PhD, Professor Department of Women s and Children s Health, Karolinska Institutet and Karolinska University Hospital, Stockholm,
More informationThe Neuroscience of Addiction: A mini-review
The Neuroscience of Addiction: A mini-review Jim Morrill, MD, PhD MGH Charlestown HealthCare Center Massachusetts General Hospital Disclosures Neither I nor my spouse/partner has a relevant financial relationship
More informationAddyi (flibanserin) When Policy Topic is covered Coverage of Addyi is recommended in those who meet the following criteria:
Addyi (flibanserin) Policy Number: 5.01.605 Last Review: 10/2018 Origination: 10/2015 Next Review: 10/2019 Policy Blue Cross and Blue Shield of Kansas City (Blue KC) will provide coverage for Addyi when
More informationOrganization of the nervous system. The withdrawal reflex. The central nervous system. Structure of a neuron. Overview
Overview The nervous system- central and peripheral The brain: The source of mind and self Neurons Neuron Communication Chemical messengers Inside the brain Parts of the brain Split Brain Patients Organization
More informationHypoactive Sexual Desire Disorder (HSDD)
Hypoactive Sexual Desire Disorder (HSDD) Sharon J. Parish, MD Professor of Medicine in Clinical Psychiatry; Professor of Clinical Medicine 10/07/17 shp9079@med.cornell.edu 1 Conflict Of Interest Disclosure
More informationNeurobiology of Addiction JeanAnne Johnson Talbert, DHA, APRN BC, FNP, CARN AP
Neurobiology of Addiction JeanAnne Johnson Talbert, DHA, APRN BC, FNP, CARN AP Disclosures This speaker has no conflicts of interest to disclose Objectives Define drug abuse and addiction Identify the
More informationbiological psychology, p. 40 The study of the nervous system, especially the brain. neuroscience, p. 40
biological psychology, p. 40 The specialized branch of psychology that studies the relationship between behavior and bodily processes and system; also called biopsychology or psychobiology. neuroscience,
More informationResearch Article /whe Womens Health (Epub ahead of print) future science group. Clayton, Althof, Kingsberg et al.
For reprint orders, please contact: reprints@futuremedicine.com Bremelanotide for female sexual dysfunctions in premenopausal women: a randomized, placebo-controlled dose-finding trial Aim: Evaluate efficacy/safety
More informationModule 1 CREATE. Diagram. Getting the hardware sorted: How your brain works. Outside appearance of the human brain
CREATE Getting the hardware sorted: How your brain works Your cognition is your ability to think, learn and remember. The human brain has been described as the most complex thing in the universe. To get
More informationPostmenopausal vulvar and vaginal atrophy (VVA)
Menopause: The Journal of The North American Menopause Society Vol. 24, No. 8, pp. 000-000 DOI: 10.1097/GME.0000000000000848 ß 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of
More informationnot for distribution MANAGEMENT OF HYPOACTIVE SEXUAL DESIRE DISORDER IN WOMEN: AWARENESS AND TREATMENTS WOMEN S SEXUAL HEALTH
WOMEN S SEXUAL HEALTH MANAGEMENT OF HYPOACTIVE SEXUAL DESIRE DISORDER IN WOMEN: AWARENESS AND TREATMENTS Diagnosis of Hypoactive Sexual Desire Disorder Dr. Marla Shapiro C.M. MDCM, CCFP. MHSc, FRCPC, FCFP,
More informationMOLECULAR BIOLOGY OF DRUG ADDICTION. Sylvane Desrivières, SGDP Centre
1 MOLECULAR BIOLOGY OF DRUG ADDICTION Sylvane Desrivières, SGDP Centre Reward 2 Humans, as well as other organisms engage in behaviours that are rewarding The pleasurable feelings provide positive reinforcement
More informationUnderstanding the Brain: What Drugs Can Tell Us
LIVE INTERACTIVE LEARNING @ YOUR DESKTOP Understanding the Brain: What Drugs Can Tell Us Presented by: Dr. Rochelle D. Schwartz-Bloom March 24, 2011 Understanding the Brain: What Drugs Can Tell Us Rochelle
More informationDEPRESSION, WHAT CAN YOU DO ABOUT IT?
DEPRESSION, WHAT CAN YOU DO ABOUT IT? by Patricia Gavotto, Psychologist Port Vila 77 46321 100 milliards de neurones About 10% of men and 25% of women will experience depression in their lifetime. Depression
More informationPsychology in Your Life
Sarah Grison Todd Heatherton Michael Gazzaniga Psychology in Your Life SECOND EDITION Chapter 2 The Role of Biology in Psychology 1 2016 W. W. Norton & Company, Inc. 2.1 How Do Our Nervous Systems Affect
More informationThe Nervous System. Neuron 01/12/2011. The Synapse: The Processor
The Nervous System Neuron Nucleus Cell body Dendrites they are part of the cell body of a neuron that collect chemical and electrical signals from other neurons at synapses and convert them into electrical
More informationIndustry Relationships and Institutional Affiliations
Efficacy and safety of alirocumab in high cardiovascular risk patients with inadequately controlled hypercholesterolaemia on maximally tolerated daily statin: results from the ODYSSEY COMBO II study Christopher
More informationFlibanserin and Female Sexual Desire
Rx Photo Pixland / thinkstockphotos.com E Editor s note: The Rx column is intended to objectively inform and report on new developments in pharmacologic treatments and medical devices. Because in many
More informationEvidence Supporting the Recommendations. Implementation of the Guideline. Benefits/Harms of Implementing the Guideline Recommendations
Management of symptomatic vulvovaginal atrophy: 2013 position statement of The North American Menopause Society Full Text Guidelinehttp://www.menopause.org/docs/default-source/2013/vva-position-statement.pdf?sfvrsn=0
More informationPhysiology Unit 2 CONSCIOUSNESS, THE BRAIN AND BEHAVIOR
Physiology Unit 2 CONSCIOUSNESS, THE BRAIN AND BEHAVIOR In Physiology Today What the Brain Does The nervous system determines states of consciousness and produces complex behaviors Any given neuron may
More informationUnit 3: The Biological Bases of Behaviour
Unit 3: The Biological Bases of Behaviour Section 1: Communication in the Nervous System Section 2: Organization in the Nervous System Section 3: Researching the Brain Section 4: The Brain Section 5: Cerebral
More information3/11/2015. The Healthy Brain & Exercise. The Benefits of Exercise. Strengthening synapses:
The Healthy Brain & Exercise Denise Gobert, PT, PhD, NCS, CEEAA Department of Physical Therapy College of Health Professions The Benefits of Exercise BLOOD FLOW SYNAPSES ENHANCED NEUROGENESIS ENHANCED
More informationEmotions: Why do we care? Emotions impact our decision making skills
The Emotional Brain Emotions: Why do we care? Emotions impact our decision making skills Emotions: Why do we care? Emotions impact our decision making skills Think about patients with frontal lobe injuries
More informationThe Contribution of Neuroscience to Understanding Human Behaviour
The Contribution of Neuroscience to Understanding Human Behaviour Gail Tripp Human Developmental Neurobiology Unit Okinawa Institute of Science and Technology Promotion Corporation Okinawa Japan Today
More informationNeurobiology of Aggression and Violence: Systems, Intervention, and Impact
Neurobiology of Aggression and Violence: Systems, Intervention, and Impact Neal G. Simon, Ph. D. Professor Dept. of Biological Sciences Lehigh University Lecture Outline 1. Overview 2. Regulatory Systems
More information1 in 68 in US. Autism Update: New research, evidence-based intervention. 1 in 45 in NJ. Selected New References. Autism Prevalence CDC 2014
Autism Update: New research, evidence-based intervention Martha S. Burns, Ph.D. Joint Appointment Professor Northwestern University. 1 Selected New References Bourgeron, Thomas (2015) From the genetic
More informationJ. John Mann, MD DIRECTOR OF THE MOLECULAR IMAGING AND NEUROPATHOLOGY DIVISION COLUMBIA UNIVERSITY NEW YORK STATE PSYCHIATRIC INSTITUTE
J. John Mann, MD DIRECTOR OF THE MOLECULAR IMAGING AND NEUROPATHOLOGY DIVISION COLUMBIA UNIVERSITY NEW YORK STATE PSYCHIATRIC INSTITUTE PAUL JANSSEN PROFESSOR OF TRANSLATIONAL NEUROSCIENCE DEPARTMENT OF
More informationGeneral Psychology Biology & Behavior: The Brain
General Psychology Biology & Behavior: The Brain These are general notes designed to assist students who are regularly attending class and reading assigned material: they are supplemental rather than exhaustive
More informationJames H. Liu, M.D. Arthur H. Bill Professor Chair of Reproductive Biology Dept of Obstetrics and Gynecology
Disclosure Estrogen Therapy After Postmenopausal Hysterectomy: Issues, Challenges, Risks/Benefits James H. Liu, M.D. Arthur H. Bill Professor Chair of Reproductive Biology Dept of Obstetrics and Gynecology
More informationCOGS 107B Systems Neuroscience. Week 6: Study Ques=ons
COGS 107B Systems Neuroscience Week 6: Study Ques=ons Auditory System II Neuromodulators and Drugs of Abuse Auditory System Neurons in the primary auditory cortex (A1) are sensi=ve to of sounds. Neurons
More informationCogs 107b Systems Neuroscience lec9_ neuromodulators and drugs of abuse principle of the week: functional anatomy
Cogs 107b Systems Neuroscience www.dnitz.com lec9_02042010 neuromodulators and drugs of abuse principle of the week: functional anatomy Professor Nitz circa 1986 neurotransmitters: mediating information
More informationChapter 3. Biological Processes
Biological Processes Psychology, Fifth Edition, James S. Nairne What s It For? Biological Solutions Communicating internally Initiating and coordinating behavior Regulating growth and other internal functions
More informationUtilizing Principles of Neuroplasticity to Guide Language Rehabilitation. Peter Meulenbroek, MA CCC-SLP University of Wisconsin-Madison
Utilizing Principles of Neuroplasticity to Guide Language Rehabilitation Peter Meulenbroek, MA CCC-SLP University of Wisconsin-Madison 1. Outline Assumptions Outline of Talk 2. Outline Principles of Neurological
More informationLesson 14. The Nervous System. Introduction to Life Processes - SCI 102 1
Lesson 14 The Nervous System Introduction to Life Processes - SCI 102 1 Structures and Functions of Nerve Cells The nervous system has two principal cell types: Neurons (nerve cells) Glia The functions
More informationLec 2b Structure and Function of Cells. Cogs17 Cognitive Neuroscience UCSD
Lec 2b Structure and Function of Cells Cogs17 Cognitive Neuroscience UCSD THE SYNAPSE Communication between cells VESICLE Double lipid membrane NTs Exocytosis VESICLE Exocytosis Double lipid membrane
More informationTreatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist
The new england journal of medicine The authors full names, academic degrees, and affiliations are listed in the Appendix. Address reprint requests to Dr. Taylor at the Department of Obstetrics, Gynecology,
More informationPhysiology Unit 2 CONSCIOUSNESS, THE BRAIN AND BEHAVIOR
Physiology Unit 2 CONSCIOUSNESS, THE BRAIN AND BEHAVIOR What the Brain Does The nervous system determines states of consciousness and produces complex behaviors Any given neuron may have as many as 200,000
More informationAdvanced Receptor Psychopharmacology
Advanced Receptor Psychopharmacology Otsuka Pharmaceutical Development & Commercialization, Inc. 2017 Otsuka Pharmaceutical Development & Commercialization, Inc., Rockville, MD February 2017 Lundbeck,
More informationThe Brain on ADHD. Ms. Komas. Introduction to Healthcare Careers
The Brain on ADHD Ms. Komas Introduction to Healthcare Careers Ms. Komas Period 9/2/2016 Komas 1 HOOK: Attention Deficit Hyperactivity Disorder (ADHD) plagues between 5% and 7% of children and less than
More informationCurricular Requirement 3: Biological Bases of Behavior
Curricular Requirement 3: Biological Bases of Behavior Name: Period: Due Key Terms for CR 3: Biological Bases of Behavior Key Term Definition Application Acetylcholine (Ach) Action potential Adrenal glands
More informationOur Agenda. Review the brain structures involved in trauma response. Review neurochemicals involved in brain response
Our Agenda Review the brain structures involved in trauma response Review neurochemicals involved in brain response Discuss impact of trauma on the child s brain Structural Response to Stress
More informationWomen s sexuality, current debates
Women s sexuality, current debates Denise Medico, M.Sc., M.A., Ph.D cand. Psychologist, Sexologist Training Course in Reproductive Health Research WHO Geneva 2008 (De)Constructing women s sexuality A dominant
More informationNeuroscience and Consciousness. Chapter 2
Neuroscience and Consciousness Chapter 2 Neurons Neuron cell communication is electrical Axon Dendrites Mylin sheath Terminal buttons Synapses Firing of neuron is electrical process All-or-none law Action
More informationNew Options for Supporting Women Having Difficulty Conceiving. James A. Simon, MD, CCD, NCMP, FACOG; Scott Roseff, MD; Howard Hait
New Options for Supporting Women Having Difficulty Conceiving James A. Simon, MD, CCD, NCMP, FACOG; Scott Roseff, MD; Howard Hait Counseling patients and their partners who are having difficulty conceiving
More informationName: Period: Chapter 2 Reading Guide The Biology of Mind
Name: Period: Chapter 2 Reading Guide The Biology of Mind The Nervous System (pp. 55-58) 1. What are nerves? 2. Complete the diagram below with definitions of each part of the nervous system. Nervous System
More informationNeocortex. Hemispheres 9/22/2010. Psychology 472 Pharmacology of Psychoactive Drugs. Structures are divided into several section or lobes.
Neocortex Psychology 472 Pharmacology of Psychoactive Drugs 1 Is the most developed in Humans Has many folds and fissures The folds of tissue are called gyri or a gyrus (single) The fissures or valleys
More informationRefractory Central Neurogenic Pain in Spinal Cord Injury. Case Presentation
Refractory Central Neurogenic Pain in Spinal Cord Injury Case Presentation Edwin B. George, MD, PhD Wayne State University John D. Dingell VAMC 2012 Disclosures This continuing education activity is managed
More informationStress Impairs Prefrontal Cortex Function: Why Stress Can Produce an ADHD-Like Profile
Stress Impairs Prefrontal Cortex Function: Why Stress Can Produce an ADHD-Like Profile Amy F.T. Arnsten, Ph.D. Professor of Neurobiology Yale University School of Medicine amy.arnsten@yale.edu SOME IMAGES
More informationnucleus accumbens septi hier-259 Nucleus+Accumbens birnlex_727
Nucleus accumbens From Wikipedia, the free encyclopedia Brain: Nucleus accumbens Nucleus accumbens visible in red. Latin NeuroNames MeSH NeuroLex ID nucleus accumbens septi hier-259 Nucleus+Accumbens birnlex_727
More informationChapter 2 The Brain or Bio Psychology
Chapter 2 The Brain or Bio Psychology 1 2 3 1 Glial Cells Surround neurons and hold them in place Make Myelin (covering for neurons) Manufacture nutrient chemicals neurons need Absorb toxins and waste
More informationJANUARY. 19TH ANNUAL Retina Fellows Forum. Westin Chicago River North, Chicago, IL
19TH ANNUAL Retina Fellows Forum SM JANUARY -, Westin Chicago River North, Chicago, IL Course Director: Course Co-Directors: Carl C. Awh, MD and David R. Chow, MD Faculty Thomas A. Albini, MD Bascom Palmer
More information9/26/2016. Disclosures. Genitourinary Syndrome of Menopause: Novel Term for Common Conditions. Objectives ISSWSH NAMS CONSENSUS CONFERENCE
Genitourinary Syndrome of Menopause: Disclosures Novel Term for Common Conditions Research, Consultant, and/or Speaker Risa Kagan, MD, FACOG, CCD, NCMP Clinical Professor, Department of Obstetrics, Gynecology,
More informationWomen s Sexual Interest/Desire Disorder : Implications of New Definition
Women s Sexual Interest/Desire Disorder : Implications of New Definition Rosemary Basson MD FRCP(UK) Vancouver General Hospital University of British Columbia Vancouver, Canada 1 New Model of Sex Response
More informationVISUAL CORTICAL PLASTICITY
VISUAL CORTICAL PLASTICITY OCULAR DOMINANCE AND OTHER VARIETIES REVIEW OF HIPPOCAMPAL LTP 1 when an axon of cell A is near enough to excite a cell B and repeatedly and consistently takes part in firing
More informationCognitive Function Test. NOR & spatial NOR task. Introduction. Novel Object Recognition (NOR) Estrogen Receptor (ER) in Brain
Cognitive Function Test Human Rodent Sutcliffe JS, Marshall KM, Neill JC. Behavioral Brain Research 177(2007) 117-125. Radial Arm maze Morris Water maze Siriporn Vongsaiyat 16 th Feb 2007 Novel Object
More informationTrauma and the Brain A Neuroscience Approach
Trauma and the Brain A Neuroscience Approach Grampians Mental Health Conference 25 March 2015 Dr. Pieter J Rossouw Developing Brain Overview Trauma Key Theories Memory Neurobiological indicators Implications
More informationVisualizing Psychology
Visualizing Psychology by Siri Carpenter & Karen Huffman PowerPoint Lecture Notes Presentation Chapter 2: Neuroscience and Biological Foundations Siri Carpenter, Yale University Karen Huffman, Palomar
More informationFundamentals of the Nervous System and Nervous Tissue: Part C
PowerPoint Lecture Slides prepared by Janice Meeking, Mount Royal College C H A P T E R 11 Fundamentals of the Nervous System and Nervous Tissue: Part C Warm Up What is a neurotransmitter? What is the
More informationHow Therapy Changes the Human Brain
Selected Neural Plasticity References How Therapy Changes the Human Brain Martha S. Burns, Ph.D.,ccc-slp Joint Appointment Professor Northwestern University Bryck & Fisher (2012) Training the Brain: Practical
More informationSincerely, Ms. Paoloni and Mrs. Whitney
Dear Students, Welcome to AP Psychology! We will begin our course of study focusing on the nervous system with a particular emphasis on how the brain and neurotransmitters influence our behaviors. In preparation
More informationUPDATED: CORINNE A. HOLMES. Trinity College, Dublin Institute of Neuroscience
UPDATED: 8.1.17 1 CORINNE A. HOLMES Trinity College, Dublin Institute of Neuroscience http://sites.temple.edu/corinneaholmes/ HOLMESCO@tcd.ie ACADEMIC APPOINTMENTS Present Post-Doctoral Fellow Institute
More informationNeural Communication. Central Nervous System Peripheral Nervous System. Communication in the Nervous System. 4 Common Components of a Neuron
Neural Communication Overview of CNS / PNS Electrical Signaling Chemical Signaling Central Nervous System Peripheral Nervous System Somatic = sensory & motor Autonomic = arousal state Parasympathetic =
More informationCURRICULUM VITAE HAROLD FRIEDMAN, M.D.
Education Undergraduate: University of Michigan, Ann Arbor, MI Medical Doctor: University of Illinois, Abraham Lincoln School of Medicine, Chicago, IL Post-Doctoral Training Internship in Internal Medicine:
More informationBIOLOGICAL PROCESSES
BIOLOGICAL PROCESSES CHAPTER 3 1 LEARNING GOALS Discuss how the nervous system communicates internally. Describe the structure and function of neurons Describe how the neuron transmits information Describe
More information2) All of our thoughts, feelings, and behaviour can be traced to the activity of the a. neurons. b. ganglia. c. genes. d. nerve fibres.
Chapter 2 Biology and Behaviour 1) The specialized cell that transmits signals throughout the nervous system is called the a. neuron. b. glial cell. c. myelin. d. neurotransmitter. Correct: The neuron
More informationAdvanced Neurotransmitters & Neuroglia
Advanced Neurotransmitters & Neuroglia Otsuka Pharmaceutical Development & Commercialization, Inc. 2017 Otsuka Pharmaceutical Development & Commercialization, Inc., Rockville, MD Lundbeck, LLC. February
More informationNeurons have cell membranes that separate them from the environment outside the neuron.
Neural Communication Lecture 11 A. Resting Potential In this section, we will consider the basic unit of the nervous system the neuron and how neurons communicate with each other. The story of neural communication
More informationSynap&c Plas&city. long-term plasticity (~30 min to lifetime) Long-term potentiation (LTP) / Long-term depression (LTD)
Synap&c Plas&city synaptic connectivity constantly changes in response to activity and other factors During development: provides the basic wiring of the brain s circuits Throughout rest of life: basis
More informationThe Neurobiology of Attention
The Neurobiology of Attention by Nadia Fike, MD/PhD Pediatric Neurology Center for Neurosciences Disclosures Nadia Fike, MD/PhD No relevant financial or nonfinancial relationships to disclose. Objectives
More informationTargets of Psychopharmacological Drug Action
Targets of Psychopharmacological Drug Action (page 33 in syllabus) Stephen M. Stahl, MD, PhD Adjunct Professor, Department of Psychiatry University of California, San Diego School of Medicine Honorary
More informationOrganization of the nervous system. [See Fig. 48.1]
Nervous System [Note: This is the text version of this lecture file. To make the lecture notes downloadable over a slow connection (e.g. modem) the figures have been replaced with figure numbers as found
More informationPsychology Unit II: The Brain and Biology
Psychology Unit II: The Brain and Biology NATURE or NURTURE What are the effects of biochemistry on behavior? VOCABULARY Central Nervous System (CNS): The central nervous system is the part of the nervous
More informationModules 4 & 6. The Biology of Mind
Modules 4 & 6 The Biology of Mind 1 Neuron - 100 Billion - Communication System Glial cells Cell body (nucleus) Dendrites Axon Axon Terminals (terminal buttons) Synaptic cleft 3 4 Communication Within
More informationGuided Reading Activities
Name Period Chapter 28: Nervous Systems Guided Reading Activities Big idea: Nervous system structure and function Answer the following questions as you read modules 28.1 28.2: 1. Your taste receptors for
More informationPROGRAM. Fall Course. International Society for the Study of Women's Sexual Health. Scottsdale, AZ - USA. November 14-16, 2014
International Society for the Study of Women's Sexual Health Fall Course PROGRAM CME Certified Live Activity Scottsdale, AZ - USA DoubleTree Resort by Hilton Hotel Paradise Valley November 14-16, 2014
More informationCHAPTER 48: NERVOUS SYSTEMS
CHAPTER 48: NERVOUS SYSTEMS Name I. AN OVERVIEW OF NERVOUS SYSTEMS A. Nervous systems perform the three overlapping functions of sensory input, integration, and motor output B. Networks of neurons with
More informationWhat are the 6 types of neuroglia and their functions?!
Warm Up! Take out your 11C Notes What are the 6 types of neuroglia and their functions?! Astrocytes Microglia Ependymal Cells Satellite Cells Schwann Cells Oligodendrocytes Support, brace, & nutrient transfer
More informationCouncil on Chemical Abuse Annual Conference November 2, The Science of Addiction: Rewiring the Brain
Council on Chemical Abuse Annual Conference November 2, 2017 The Science of Addiction: Rewiring the Brain David Reyher, MSW, CAADC Behavioral Health Program Director Alvernia University Defining Addiction
More informationBiological Process 9/7/10. (a) Anatomy: Neurons have three basic parts. 1. The Nervous System: The communication system of your body and brain
Biological Process Overview 1. The Nervous System: s (a) Anatomy, (b) Communication, (c) Networks 2. CNS/PNS 3. The Brain (a) Anatomy, (b) Localization of function 4. Methods to study the brain (Dr. Heidenreich)
More informationLAUREN C. ANDERSON Boston College, Department of Psychology Chestnut Hill, MA
LAUREN C. ANDERSON Boston College, Department of Psychology Chestnut Hill, MA 02467 andersvz@bc.edu EDUCATION 2014-present Boston College, Chestnut Hill, MA Intended Degree: Doctor of Philosophy Completion
More informationNational & International Lectures
2005-2008 National & International Lectures 6/24/05 ECFS Crete, Greece Mucoid Psuedomonas aeruginosa Infection, Antibiotic Resistance, and Lung Disease Progression in Children with Cystic Fibrosis 9/30/05
More information