COGS 107B Systems Neuroscience. Week 6: Study Ques=ons

Transcription

1 COGS 107B Systems Neuroscience Week 6: Study Ques=ons

2 Auditory System II Neuromodulators and Drugs of Abuse

3 Auditory System

4 Neurons in the primary auditory cortex (A1) are sensi=ve to of sounds.

5 Neurons in the primary auditory cortex (A1) are sensi=ve to frequency of sounds.

6 Although A1 neurons respond best to sounds at par=cular frequencies, those responses can vary greatly according to and.

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8 Although A1 neurons respond best to sounds at par=cular frequencies, those responses can vary greatly according to sound amplitude and the temporal ordering of sound.

9 Neuromodulators and Drugs of Abuse

10 mediate informa=on exchange between neurons through genera=on of synap=c poten=als.

11 NeurotransmiQers mediate informa=on exchange between neurons through genera=on of synap=c poten=als.

12 Name the three types of neurotransmiqers:

13 Name the three types of neurotransmiqers: Ionotropic excitatory Ionotropic inhibitory Metabotropic/neuromodulatory

14 What effect do ionotropic excitatory neurotransmiqers have on the post- synap=c cell?

15 What effect do ionotropic excitatory neurotransmiqers have on the post- synap=c cell? Cause excitatory post- synap=c poten=als (EPSP)

16 What effect do ionotropic inhibitory neurotransmiqers have on the post- synap=c cell?

17 What effect do ionotropic inhibitory neurotransmiqers have on the post- synap=c cell? Cause inhibitory post- synap=c poten=als (IPSP)

18 Specify whether the following neurotransmiqers are ionotropic excitatory or ionotropic inhibitory (i.e. cause EPSP or IPSP) Glutamate : Glycine : GABA : ACh: :

19 Specify whether the following neurotransmiqers are ionotropic excitatory or ionotropic inhibitory (i.e. cause EPSP or IPSP) Glutamate : ionotropic excitatory Glycine : ionotropic inhibitory GABA : ionotropic inhibitory ACh: : ionotropic excitatory

20 influence the neuronal responses to ionotropic excitatory and inhibitory inputs as opposed to directly media=ng excitatory or inhibitory responses.

21 Neuromodulators influence the neuronal responses to ionotropic excitatory and inhibitory inputs as opposed to directly media=ng excitatory or inhibitory responses.

22 Name 3 neuromodulatory neurotransmiqers:

23 Name 3 neuromodulatory neurotransmiqers: norepinephrine serotonin dopamine

24 Neuromodulatory systems of the brain have [low / high] firing rates.

25 Neuromodulatory systems of the brain have [low / high] firing rates.

26 Name 3 neurological disorders that are associated with brain s neuromodulatory systems. 1) 2) 3)

27 Name 3 neurological disorders that are associated with brain s neuromodulatory systems, and responsible neurotransmiqer: 1) Alzheimer s 2) Depression 3) Schizophrenia

28 Alzheimer s is a neurological disorder that is associated with which neuromodulatory system of the brain: a) ACh b) DA (Dopamine) c) NE (Nor- epinephrine) d) Serotonin

29 Alzheimer s is a neurological disorder that is associated with which neuromodulatory system of the brain: a) ACh b) DA (Dopamine) c) NE (Nor- epinephrine) d) Serotonin

30 Depression is a neurological disorder that is associated with which neuromodulatory system of the brain: a) ACh b) DA (Dopamine) c) NE (Nor- epinephrine) d) Serotonin (5- HT)

31 Depresssion is a neurological disorder that is associated with which neuromodulatory system of the brain: a) ACh b) DA (Dopamine) c) NE (Nor- epinephrine) d) Serotonin

32 Schizophrenia is a neurological disorder that is associated with which neuromodulatory system of the brain: a) ACh b) DA (Dopamine) c) NE (Nor- epinephrine) d) Serotonin

33 Schizophrenia is a neurological disorder that is associated with which neuromodulatory system of the brain: a) ACh b) DA (Dopamine) c) NE (Nor- epinephrine) d) Serotonin

34 Ecstasy is a drug of abuse that affects which of the following neuromodulatory systems: a) ACh b) Serotonin (5- HT) c) Nor- epinephrine (NE) d) Dopamine (DA)

35 Ecstasy is a drug of abuse that affects which of the following neuromodulatory systems: a) ACh b) Serotonin (5- HT) c) Nor- epinephrine (NE) d) Dopamine (DA)

36 Cocaine is a drug of abuse that affects which of the following neuromodulatory systems: a) ACh b) Serotonin (5- HT) c) Nor- epinephrine (NE) d) Dopamine (DA)

37 Cocaine is a drug of abuse that affects which of the following neuromodulatory systems: a) ACh b) Serotonin (5- HT) c) Nor- epinephrine (NE) d) Dopamine (DA)

38 Nico=ne is a drug of abuse that affects which of the following neuromodulatory systems: a) ACh b) Serotonin (5- HT) c) Nor- epinephrine (NE) d) Dopamine (DA)

39 Nico=ne is a drug of abuse that affects which of the following neuromodulatory systems: a) ACh b) Serotonin (5- HT) c) Nor- epinephrine (NE) d) Dopamine (DA)