HEART AND STROKE FOUNDATION RESEARCH REPORT

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1 HEART AND STROKE FOUNDATION RESEARCH REPORT

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3 Heart and Stroke Foundation Research Report MISSION The Heart and Stroke Foundation s mission is to prevent disease, save lives and promote recovery. A volunteer-based health charity, we strive to tangibly improve the health of every Canadian family, every day. Healthy lives free of heart disease and stroke. Together we will make it happen. Every seven minutes in Canada, someone dies from heart disease or stroke. Heart disease and stroke are two of the three leading causes of death in Canada; more than 62,000 strokes, an estimated 70,000 heart attacks, and up to 40,000 cardiac arrests occur every year. Since its inception in 1952, the Foundation has invested more than $1.45 billion into vital heart and stroke research, making it the largest contributor in Canada after the federal government. Over the past 60 years, thanks to the work of the Foundation and our partners, the death rate from heart disease and stroke in Canada has declined by more than 75 per cent. This decline has resulted in 1.6 million people living with their effects today. Cover Photo: Dr. Rob Beanlands (University of Ottawa Heart Institute) is the Chair of the Heart and Stroke Foundation of Canada s Scientific Review Committee (), a member of CoMPASS, and a recipient of a Grant-in-Aid and a Career Investigator Award in i

4 Heart and Stroke Foundation Research Report TABLE OF CONTENTS ACKNOWLEDGEMENTS PURPOSE AND SCOPE SUMMARY TABLES RESEARCH FUNDING OVERVIEW Scientific Review Process Research Enterprise Components Investments across Health Research Themes RESEARCH FUNDING BY PROGRAM Directed Research Fund National Personnel Awards Heart and Stroke Foundation Prestigious Awards Grant-in-Aid Province-specific Research Initiatives Research Chairs and Professorships Provincial Personnel Awards Other Provincial Initiatives TABLES Table 1. Summary Foundation-wide and Province Specific Research Funding ()... 2 Table 2. Detailed Foundation-wide and Province-specific Research Funding ()... 3 Table 3. Number of National Personnel Awards and Investment of Funds ()... 9 Table 4. National Personnel Awards by Health Research Theme ()... 9 Table 5. Number of Grants-in-Aid and Investment of Funds () Table 6. Research Chairs and Professorships () Table 7. HSF Provincial Personnel Awards Funded () Table 8. Other Provincial Research Initiatives () FIGURES Figure 1. HSF Research Funding by Program ()... 5 Figure 2. HSF Research Funding Trends by Program (2010-)... 6 Figure 3. HSF Research Funding by Health Research Theme ()... 6 Figure 4. HSF Research Funding Trends by Health Research Theme (2010-)... 6 Figure 5. Directed Research Fund Leveraged Funding (2010-)... 7 Figure 6. Directed Research Fund Funding by Health Research Theme ()... 8 Figure 7. Directed Research Fund Funding Trends by Health Research Theme (2010-)... 8 Figure 8. National Personnel Awards Funding by Health Research Theme () Figure 9. National Personnel Awards Funding Trends by Health Research Theme (2010-) Figure 10. Number of National Personnel Award Applications Submitted and Funded by Province/Territory () Figure 11. Grant-in-Aid Funding by Health Research Theme () Figure 12. Grant-in-Aid Funding Trends by Health Research Theme (2010-) Figure 13. Number of Grant-in-Aid Applications Submitted by Province(s)/Territory(ies) (2010-) Figure 14. Number of Grant-in-Aid Applications Funded by Province/Territory (2010-) ii

5 Heart and Stroke Foundation Research Report APPENDIX A: DIRECTED RESEARCH FUND NEW INITIATIVE Operating Grant: Population Health Intervention Research CONTINUING INITIATIVES Coalitions Linking Action and Science for Prevention 2 (CLASP2) Canadian Partnership for Tomorrow Project (CPTP) Canadian Alliance for Healthy Hearts and Minds (CAHHM) CIHR/HSFC Training Awards in Population Intervention for Chronic Disease Prevention: A Pan-Canadian Program Emerging Network: Canadian Stroke Prevention Intervention Network (C-SPIN) HSFC/CIHR Chair in Hypertension Prevention and Control Operating Grant: Programmatic Grants in Health and Health Equity Clinical Imaging Team Grants Resuscitation Outcomes Consortium (ROC) Renewal APPENDIX B: NATIONAL PERSONNEL AWARDS Doctoral Research Awards Focus on Stroke Doctoral Research Awards Research Fellowships Focus on Stroke Research Fellowships Research Scholarships Focus on Stroke Research Scholarships New Investigators Distinguished Clinician Scientist Industry-Supported Research Fellowship Awards APPENDIX C: GRANTS-IN-AID British Columbia/Yukon Alberta/Northwest Territories/Nunavut Saskatchewan Manitoba Ontario Quebec Nova Scotia Newfoundland and Labrador APPENDIX D: RESEARCH CHAIRS AND PROFESSORSHIPS APPENDIX E: PROVINCIAL PERSONNEL AWARDS Alberta/Northwest Territories/Nunavut Manitoba Ontario Newfoundland and Labrador APPENDIX F: OTHER PROVINCIAL INITIATIVES British Columbia/Yukon Alberta/Northwest Territories/Nunavut Manitoba Ontario Quebec Nova Scotia APPENDIX G: RESEARCH COMMITTEE MEMBERS APPENDIX H: DEFINITION OF HEALTH RESEARCH THEMES iii

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7 Heart and Stroke Foundation Research Report ACKNOWLEDGEMENTS Each year, individuals across Canada join together to further the Heart and Stroke Foundation (HSF) mission of eliminating heart disease and stroke. Canadians from coast to coast to coast donate valuable resources, including their time, money, and expertise, to improve the health and quality of life of all Canadians. The following groups deserve special thanks: Donors. Providing funds to support heart and stroke research is the first step in a process which culminates in scientific breakthroughs that touch all our lives. The donors and volunteers in every community across Canada that have supported the Foundation s fundraising efforts have made lasting investments in the future health and well being of Canadians. Council on Mission: Priorities, Advice, Science and Strategy (CoMPASS). The Foundation s primary mechanism for informing Mission directions. Comprised of a cadre of thoughtfully selected, dedicated Canadian experts and HSF Mission champions, the CoMPASS mandate is to provide considered and strategic advice on Mission priorities. The members of this committee are identified in Appendix G (page 86). Scientific Review Committees. The scientific and lay reviewers expertise and commitment enable HSF to fund the highest standard of scientific excellence. Exemplary leadership to over 150 volunteer reviewers has been provided by the Scientific Review Committee s Chair and Vice Chair, Drs Rob Beanlands and Glen Tibbits, respectively. The Chairs of HSF s vital peer review committees across the Foundation are identified in Appendix G (page 87). 1. PURPOSE AND SCOPE The purpose of this report is two-fold: 1. To illustrate the Heart and Stroke Foundation s overall research investments made in across all research funding programs and initiatives. 2. To serve as a reference tool for volunteers and staff across the Heart and Stroke Foundation, the research community, other research funding agencies, and academic institutions. This report covers the period from July 1, 2014 to June 30,. It is a snapshot of expenditures in research during that period. The report presents financial and statistical data for new grants and awards made in, as well as continued funding of previously reported multi-year grants and awards. Heart and Stroke Researchers. Each one of HSF s researchers, through extraordinary work, contributes to advancements in the understanding of cardio- and cerebrovascular disease. The knowledge gained from their efforts leads to earlier diagnoses, better treatments and new insights into prevention. Their ongoing commitment to the advancement of knowledge helps HSF move closer to achieving its mission. Partners. A number of organizations collaborated with HSF in, enabling the Foundation to leverage funding and resources for heart and stroke research. 1

8 Heart and Stroke Foundation Research Report 2. SUMMARY TABLES Table 1. Summary Foundation-wide and Province Specific Research Funding () Province(s)/ Territory(ies) Foundation-wide Research Initiatives Province-specific Research Initiatives Total Grant-in-Aid National Personnel Awards Directed Research Fund Personnel Awards Chairs Other # $ # $ # $ # $ # # $ # $ 19 1,638, , ,838,358 British Columbia/ Yukon Alberta/Northwest 38 2,693, , , ,105,222 Territories/Nunavut Saskatchewan 3 115, ,539 Manitoba 7 573, , , ,433 Ontario 105 9,322, ,935, , ,817,749 Quebec 39 1,748, , ,811,735 New Brunswick Nova Scotia 5 333, , ,023 Prince Edward Island Newfoundland and 1 35, , ,868 Labrador All ** ,442,803* 16 1,924, ,000, ,366,803 TOTAL 217 $16,460, $3,442, $1,924, $3,081, $3,224, $28,132,730 *Includes award stipends and applicable travel and/or allowances. **Denotes competitions/initiatives eligible nationally. HSF contributions to the Canadian Partnership for Stroke Recovery For the most part, Research Chair and Professorship awards are funded by endowments and are partnered with academic / health research institutions. The amounts, therefore, are not shown in the financial charts/summary information provided with this report. 2

9 Heart and Stroke Foundation Research Report Table 2. Detailed Foundation-wide and Province-specific Research Funding () Province(s)/Territory(ies) Program Awards (#) Awards ($) Total ($) British Columbia/Yukon Grant-in-Aid 19 1,638,358 Research Chairs*: Chair in Caridiology Research 1 - Chair in Cardiovascular Prevention Research 1 - Professorship in Clinical Stroke Research 1 - Professorship in Women's Cardiovascular Health 1 - Other Provincial Initiatives: HSF-UBC Cardiology Research Partnership: ,000 Cardiology Academic Practice Plan 1,838,358 Alberta/ Grant-in-Aid 38 2,693,722 Northwest Territories/ Nunavut Research Chairs*: Chair in Cardiovascular Research 2 - Chair in Stroke Research 1 - Professorship in Cardiovascular Research 1 - Professorship in Stroke Research 3 - Professorship in Neonatal Resuscitation 1 - Personnel Awards: New Investigator Awards 2 120,000 Other Provincial Initiatives: Seed Grants 5 221,500 Bridge Grant 1 70,000 3,105,222 Saskatchewan Grant-in-Aid 3 115,539 Research Chairs*: Chair in Clinical Stroke Research 1-115,539 Manitoba Grant-in-Aid 7 573,462 Research Chairs*: Chair in Primary Prevention 1 - Personnel Awards: Sanofi Canada - Heart and Stroke Foundation, Manitoba Award in Cardiology 1 10,000 Master's Student Award 1 1,000 Dr. Dexter Harvey Award 1 5,000 Other Provincial Initiatives: Primary Prevention Challenge Grant 2 79, ,433 3

10 Heart and Stroke Foundation Research Report Province(s)/Territory(ies) Program Awards (#) Awards ($) Total ($) Ontario Grant-in-Aid 105 9,322,249 Research Chairs*: Chair in Population Health Research 1 - Chair in Cardiac Nursing 1 - Chair in Cardiovascular Research 5 - Chair in Aboriginal and Rural Health 1 - Personnel Awards: Career Investigator 20 1,618,500 Clinician Scientist 4 300,000 Mid-Career Investigator ,000 Summer Student Scholarship 14 57,000 Other Provincial Initiatives: Bridge Grant 8 560,000 12,817,749 Quebec Grant-in-Aid 39 1,748,468 Other Provincial Initiatives: Awards for Excellence in Research 5 50,000 Training Bursaries 2 13,267 1,811,735 New Brunswick Grant-in-Aid Nova Scotia Grant-in-Aid 5 333,023 Research Chairs*: Chair in Cardiology Research 1 - Other Provincial Initiatives: Dr. Gregory Ferrier Award 1 5,000 BrightRed Graduate Research Award 5 25, ,023 Prince Edward Island Grant-in-Aid Newfoundland and Grant-in-Aid 1 35,368 Labrador Personnel Awards: Graduate Scholarship 1 1,500 Grant - NeuroFIT Program 1 3,500 Keith Griffiths Memorial Scholarship 1 1,500 Undergraduate Nursing Award in Cardiovascular Health 1 1,500 Undergraduate Nursing Award in Stroke 1 1,500 44,868 SUBTOTAL ,765,926 20,765,926 Directed Research Fund 16 1,924,000 1,924,000 National Personnel Awards 95 3,442,803 3,442,803 Heart and Stroke Foundation Canadian Partnership for Stroke Recovery - 2,000,000 2,000,000 TOTAL 450 $28,132,730 $28,132,730 * For the most part, Research Chair and Professorship awards are funded by endowments and are partnered with academic / health research institutions. Includes award stipends and applicable travel and/or allowances. HSF contributions to the Canadian Partnership for Stroke Recovery. 4

11 Heart and Stroke Foundation Research Report 3. RESEARCH FUNDING OVERVIEW 3.1 Scientific Review Process Scientific peer review is the cornerstone of the Foundation s research enterprise. All research funded by HSF, at a national or provincial level, undergoes peer review and must meet criteria for scientific rigor. The purpose of peer review is to ensure excellence in research funded by HSF. Peer review is carried out by committees of experts (peer review committees) that encompasses all four themes of health research (basic biomedical, clinical, health services/systems, and social, cultural, environmental and population health). The Foundation s peer review is overseen by the Scientific Review Committee (SRC). For recurring competitions, standing peer review committees are formed, and committee members are recruited for a term of service (typically three years) in order to ensure consistency and continuity in the review process. Standing committee membership may be supplemented by additional members as required, based on the applications received and expertise needed for their review. For ad hoc competitions, committees are formed to review applications for that particular competition. A typical SRC peer review committee consists of a Chair, Deputy Chair, scientific peer reviewers, HSF staff secretariat and other specialized roles, such as lay reviewers or knowledge users, depending on the funding opportunity. Committee members are selected for their high levels of expertise related to the mandate of the review committee and their experience in evaluating and reviewing research funding applications. In addition, membership balances expertise, and ensure that each committee has the capacity to review applications submitted in English or French. Peer review meetings are held in English, but internal and external reviewers are assigned with linguistic abilities in mind. Standard Steps in Peer Review Process: 1. Applications submitted to the Heart and Stroke Foundation are administratively reviewed and sorted into their appropriate committee. 2. An allocation meeting to distribute applications is held. The Chair and Deputy Chair of the committee select two internal reviewers (and any required external reviewers) for each application. Internal reviewers are members of the SRC who meet face to face whereas external reviewers are members of the scientific community across Canada and internationally selected for their particular expertise. External reviewers supplement the expertise of the panels and provide written comments on the application submitted. The Foundation relies on the support and commitment of many researchers across Canada and internationally to ensure this process is effective. 3. Peer review meetings are held in December through to March where the applications are discussed. The Chair or Deputy Chair writes an SRC report which summarizes the discussion and the application is rated. 4. Based on the ratings/rankings as well as available funds, the Foundation determines which Grants and Awards will be funded. In, over 150 of Canada s top cardio- and cerebrovascular scientists participated on the SRC. 3.2 Research Enterprise Components The HSF research enterprise contains four key parts presented in Figure 1. The Grant-in-Aid program (research project operating grants); the National Personnel Awards program (salary awards at doctoral, post doctoral, and new investigator levels); the Directed Research Fund initiatives (strategic research initiatives primarily in partnership with other funding agencies); and provincial research initiatives (personnel awards, program grants, and other programs). Figure 1. HSF Research Funding by Program () Grant-in-Aid $16,460,189 59% National Personnel Awards $3,442,803 12% Heart and Stroke Foundation Canadian Partnership for Stroke Recovery $2,000,000 7% Directed Research Fund $1,924,000 7% Provincial Research Initiatives $4,305,738 15% 5

12 Heart and Stroke Foundation Research Report Figure 2. HSF Research Funding Trends by Program (2010-) Numbers represent $ Millions Directed Research Fund health research theme in each of the Foundation- wide programs is presented. Currently, we do not have data on provincial initiatives by theme. Figure 3. HSF Research Funding by Health Research Theme () Clinical 24% National Personnel Awards Health Services/ Basic Systems 6% Biomedical 64% Social, Cultural, Environmental and Population Health 6% Basic Biomedical fig 3 eng Grant-in-Aid Provincial Research Initiatives Clinical 24% Health Services/ Systems 6% 64% Social, Cultural, Total Environmental and 51.9 Population Health % Does not include Chair and Professorship values. Includes Heart and Stroke Foundation Canadian Partnership for Stroke Recovery value. 3.3 Investments across Health Research Themes Research supported by HSF spans the four health research themes: basic biomedical, clinical, health services/systems, and social, cultural, environmental and population health (defined in Appendix H). Figures 3 and 4 show the relative HSF investments across health research themes. Further in the report, funding by Includes Directed Research Fund, National Personnel Awards (stipends only), and Grant-in-Aid funding. Figure 4. HSF Research Funding Trends by Health Research Theme (2010-) Numbers represent $ Millions Basic Biomedical Clinical Health Services/Systems Social, Cultural, Environmental and Population Health Includes Includes Directed Directed Research Research Fund, Fund, National National Personnel Personnel Awards (stipends only), and Grant-in-Aid Awards (stipends funding. only), and Grant-in-Aid funding. 6

13 Heart and Stroke Foundation Research Report 4. RESEARCH FUNDING BY PROGRAM This section provides summary information for each of the four main components of the HSF research enterprise: Foundation-wide research programs: 1. Directed Research Fund 2. National Personnel Awards 3. Grant-in-Aid 4. Province-specific research initiatives: i. Provincial Research Chairs and Professorships ii. Provincial Personnel Awards iii. Other Provincial Research Initiatives 4.1 Directed Research Fund The Directed Research Fund (DRF) supports research in areas of strategic priority to the Foundation, typically through a Request for Applications process, and in partnership with other agencies and organizations. New initiative appearing in this year s report: 1) Operating Grant: Population Health Intervention Research. The purpose of this funding opportunity is to support the prompt initiation of population health intervention research on rapidly unfolding programs, policies and resource distribution approaches that have been initiated by others (e.g., policy makers) and have the potential to impact health and health equity at the population level. Many such interventions are unfolding and evolving constantly across the country, making the opportunities to initiate research more short-lived than most funding streams can effectively support. They are often planned and funded by community, non-profit, private, and/ or public organizations both within and outside of the health sector (e.g., housing, environment and education). However, these efforts lack the embedded mechanisms needed for the rigorous assessment of processes and outcomes, sharing of lessons learned, and application of this knowledge to new program and policy decisions. The total value of the Foundation s investment in these strategic projects for is over $1.9 million. In addition to the Foundation s investment, partner funds have further extended the DRF research portfolio, leveraging donors dollars. As outlined in Figure 5, Foundation funding is leveraged by a ratio of five to one. Over a 5 year period, the Foundation has taken steps to more fully align the DRF s investments with the strategic mission priorities of the Foundation. Figure 5. Directed Research Fund Leveraged Funding (2010-) Numbers represent $ Millions HSFC Partner(s) One of the objectives of the DRF is to support multidisciplinary research in the areas of health services/systems and social, cultural, environmental and population health. Figures 6 and 7 illustrate significant progress in achieving this objective while remaining responsive across health research themes. The majority of the projects listed in Appendix A represent the continuation of previously reported research investments. A total of 9 initiatives, representing 16 individual grants and awards, are detailed in Appendix A. 7

14 Heart and Stroke Foundation Research Report Figure 6. Directed Research Fund Funding by Health Research Theme () Health Services/ Systems 14% Social, Cultural, Environmental and Population Health 40% Clinical 45% Basic Biomedical 1% Figure 7. Directed Research Fund Funding Trends by Health Research Theme (2010-) Numbers represent $ Millions Basic Biomedical National Personnel Awards National Personnel Awards build Canada s cardio- and cerebrovascular research capacity by providing salary support to investigators at early scientific career stages. The programs included Distinguished Clinician Scientist, New Investigator, Research Scholarship, Research Fellowship and Doctoral Research Award. National Personnel Awards Programs in Distinguished Clinician Scientist A salary award to support clinical new investigators who wish to establish their own independent research laboratory. This award is given to the highest ranked eligible clinician in the New Investigator competition ($75,000 stipend + $25,000 research allowance per Social, Cultural, Environmental year for five years, Health including Services/ fringe benefits). and Population Health 2% Systems 5% New Investigator A salary award to support new investigators who wish to establish their own independent research laboratory Clinical ($60,000 per year 31% for five years, including fringe benefits) Clinical Health Services/Systems Social, Cultural, Environmental and Population Health Research Scholarship A salary award intended Basic for individuals with a Masters and/or PhD and Biomedical with credential(s) in a regulated accredited health 62% discipline. The applicant must hold a faculty appointment and have less than five years research experience. ($45,000 + $5,000 research allowance, per year for two years). Research Fellowship A training award for applicants who have completed a doctorate level professional degree, MD or PhD ($40,000 or $50,000 + $1,500 travel allowance per year for up to two or three years, depending upon eligibility). Doctoral Research Award A training award for graduate students, enrolled in a PhD program, who are undertaking full-time research training ($21,000 + $1,000 travel allowance per year for up to three years). Total

15 Heart and Stroke Foundation Research Report Additional salary support was offered through the Focus on Stroke initiative. Focus on Stroke Initiative The emphasis of this award is on building capacity in the later themes/ pillars of stroke research (i.e., clinical, health services/ policy, and/or social, cultural, environmental and population health) and supporting research training of health professionals (e.g. nurses, occupational therapists, pharmacists, physiotherapists, speech therapists). This initiative is offered through Doctoral Research Awards, Research Fellowships, and Research Scholarships. Table 3. Number of National Personnel Awards and Investment of Funds () Program Recipients (#) Funds Invested ($) Distinguished Clinician 3 200,000 Scientist New Investigator ,000 Research Scholarship 2 90,000 Research Fellowship 52 1,693,199 Doctoral Research Award ,500 Research Allowance - 109,750 Travel Allowance - 67,354 TOTAL 95 $3,442,803 Table 4 highlights the distribution of National Personnel Awards by health research theme. In, 95 new and continuing awards were funded. This included 2 awards supported in part by industry. The total HSF investment in National Personnel Awards in was over $3.4 million (Table 3). A list of award recipients can be found in Appendix B. Table 4. National Personnel Awards by Health Research Theme () Type of Award Basic Biomedical Clinical Health Services/ Systems Social, Cultural, Environmental and Population Health Total (#) ($) (#) ($) (#) ($) (#) ($) (#) ($) Distinguished Clinician , , , , ,000 Scientist New Investigator , , , , ,000 Research Scholarship , , ,000 Research Fellowship ,200, , , , ,693,199 Doctoral Research Award , , , ,500 TOTAL 60.6 $2,009, $1,012, $170, $73, $3,265,699 Includes award stipends only. 9

16 Canadians stu Heart and Stroke Foundation Research Report Figure 8. National Personnel Awards Funding by Health Research Theme () Figure 9. National Personnel Awards Funding Trends by Health Research Theme (2010-) Numbers represent $ Millions ronmental th 2% Social, Cultural, Environmental and Population Health 2% Health Services/ Systems 5% Health Services/ Systems 5% Clinical 31% Basic Biomedical Clinical Basic 31% Biomedical 62% Includes award stipends only Clinical Alta./N al Health Services/Systems eng Social, Cultural, Environmental and Population Health Includes award Total stipends only There is a wide variation in applications 3.6 submitted and funded by province (see Figure 10). The overall 4.9 success rate 2014 for the National Personnel Awards 3.9 competitions in 3.3 was approximately 15%. fig 9 eng 10

17 Heart and Stroke Foundation Research Report Figure 10. Number of National Personnel Award Applications Submitted and Funded by Province/ Territory () B.C./Yukon Alta./N.W.T./Nunavut Sask Applications Submitted Applications Funded Heart and Stroke Foundation Prestigious Awards Each year, the Heart and Stroke Foundation recognizes leadership and scientific excellence through the following prestigious awards. McDonald Scholarship The McDonald Scholarship is named in honour of Ewing McDonald, the Heart and Stroke Foundation of Canada s Executive Director from 1968 to This award is given annually to the highest-rated applicant in the New Investigator program. The recipient is awarded a $15,000 research grant (in addition to the New Investigator/ Distinguished Clinician Scientist award stipend). Man. Ont. Que. N.B. N.S. P.E.I. N.L. Canadians studying abroad Dr. Robert A. Rose from Dalhousie University was the Heart and Stroke Foundation s McDonald Scholar. Dr. Rose is studying how a specific group of hormones, called natriuretic peptides, affect the physiology of the healthy heart, as well as the diseased heart. Henry J.M. Barnett Scholarship The Henry J.M. Barnett Scholarship was established to honour Dr. Henry J.M. Barnett s exceptional contributions to stroke research, education, and patient care in Canada. This award is presented annually to a highly rated investigator applicant working in stroke research. The recipient is awarded a $15,000 research grant (in addition to their award stipend). Dr. Richard H. Swartz, a New Investigator recipient from Sunnybrook Health Sciences Centre was the Heart and Stroke Foundation s Barnett Scholar. Dr. Swartz wants to show that screening for Depression, Obstructive sleep apnea (OSA) and Cognitive impairment (DOC) conditions can identify people at high risk of bad outcomes. 4 th ICPC/HSFC/CCS Fellowship in Preventive Cardiology The 4 th ICPC/HSFC/CCS Fellowship in Preventive Cardiology was established by the Heart and Stroke Foundation of Canada (HSFC) and the Canadian Cardiovascular Society (CCS), with a grant from the profits of the 4th International Conference on Preventive Cardiology (ICPC) held in Montreal in The fellowship is awarded to an individual who wishes to undertake post-graduate training in preventive cardiology in a recognized institution in Canada or abroad. In, Dr. Andraea van Hulst from McGill University was the recipient of the 4 th ICPC/HSFC/ CCS Fellowship in Preventive Cardiology award. Dr. van Hulst wants to find out whether the ACCELERATION health program is effective at improving the following health behaviours among participants: physical activity, healthy eating, smoking cessation and moderate to low alcohol intake. 11

18 Heart and Stroke Foundation Research Report 4.3 Grant-in-Aid Grants-in-Aid form the largest category of research expenditure for the Heart and Stroke Foundation. The Grant-in-Aid program supports the direct operating costs of conducting research, including laboratory supplies, technicians, and some equipment. In, 217 Grants-in-Aid (new and continuing) were funded, representing an investment of over $16 million (Table 5). A list of grant recipients can be found in Appendix C. Table 5. Number of Grants-in-Aid and Investment of Funds () Province(s)/Territory(ies) Recipients (#) Funds Invested ($) British Columbia/Yukon 19 1,638,358 Alberta/Northwest Territories/Nunavut 38 2,693,722 Saskatchewan 3 115,539 Manitoba 7 573,462 Ontario 105 9,322,249 Quebec 39 1,748,468 New Brunswick - - Nova Scotia 5 333,023 Prince-Edward-Island - - Newfoundland and Labrador 1 35,368 TOTAL 217 $16,460,189 Figure 11. Grant-in-Aid Funding by Health Research Theme () Clinical 20% Figure 12. Grant-in-Aid Funding Trends by Health Research Theme (2010-) Numbers represent $ Millions Basic Biomedical Clinical Health Services/Systems Social, Cultural, Environmental and Population Health The number of applications submitted and funded in the Grant-in-Aid program varies widely across provinces (Figures 13 and 14). The overall success rate for the Grant-in-Aid competition in was approximately 15%. Health Services/ Systems 5% Social, Cultural, Environmental and Population Health 3% Basic Biomedical 72% Total

19 Heart and Stroke Foundation Research Report resent $ Millions Figure 13. Number of Grant-in-Aid Applications Submitted by Province/Territory (2010-) B.C./Yukon /Nunavut Alta./N.W.T./Nunavut Sask Man Figure 14. Number of Grant-in-Aid Applications Funded by Province/Territory (2010-) Numbers represent $ Millions B.C./Yukon Alta./N.W.T./Nunavut Sask Man Ont Ont Que Que N.B N.B N.S N.S P.E.I. N.L N.L P.E.I N.L

20 Heart and Stroke Foundation Research Report 4.4 Province-specific Research Initiatives In addition to the Grant-in-Aid program, many of the provincial offices administer Research Chairs and Professorships; provincial Personnel Awards; and other research initiatives Research Chairs and Professorships Research Chair funding provides salary and infrastructure support to enable a leading researcher to develop a particular research focus at a Canadian university. In a total of 23 Chairs and Professorships were supported by HSF in the areas of aboriginal and rural health, cardiology, cardiac nursing, stroke, neonatal resuscitation, population health and primary prevention. The recipients of these Chairs and Professorships can be found in Appendix D. In, two new Professorships were established in partnership with the Universities of Alberta and Calgary. Professors will develop and maintain world-class cardio- or cerebrovascular research programs in collaboration with diverse provincial and national research groups to collectively achieve impact. Dr. Bijoy Menon was appointed as the inaugural Heart and Stroke Foundation/ University of Calgary Professor in Stroke Imaging. He is focusing on the tiniest brain blood vessels (collaterals) which serve as the blood s detour route when a stroke occurs. Dr. Menon collaborates with an interdisciplinary team of researchers and clinicians at the University of Calgary to improve stroke care and treatment. Dr. Georg Schmolzer was appointed as the inauguaral Heart and Stroke Foundation/University of Alberta Professor in Neonatal Resuscitation. Dr. Schmolzer is aiming to improve current newborn CPR practices to enhance infant survival. The University of Alberta hospital network includes one of the largest neonatal intensive care units in North America and is the largest perinatal center for premature infants in Canada with approximately 2,000 high-risk deliveries every year. This research will inform and improve neonatal CPR guidelines. Table 6. Research Chairs and Professorships () Province(s)/Territory(ies) Program Awards (#) Total (#) British Columbia/Yukon Chair in Caridiology Research 1 Chair in Cardiovascular Prevention Research 1 Professorship in Clinical Stroke Research 1 Professorship in Women's Cardiovascular Health 1 4 Alberta/Northwest Territories/Nunavut Chair in Cardiovascular Research 2 Chair in Stroke Research 1 Professorship in Cardiovascular Research 1 Professorship in Stroke Research 3 Professorship in Neonatal Resuscitation 1 8 Saskatchewan Chair in Clinical Stroke Research 1 1 Manitoba Chair in Primary Prevention 1 1 Ontario Chair in Population Health Research 1 Chair in Cardiac Nursing 1 Chair in Cardiovascular Research 5 Chair in Aboriginal and Rural Health 1 8 Quebec New Brunswick Nova Scotia Chair in Cardiology Research 1 1 Prince Edward Island Newfoundland and Labrador TOTAL For the most part, Research Chair awards are funded by endowments and are partnered with academic/health research institutions. 14

21 Heart and Stroke Foundation Research Report Provincial Personnel Awards In, the provincial offices funded a total of 60 Personnel Awards, building capacity by supporting cardio- and cerebrovascular researchers throughout their careers, from high school students working in research settings to established senior scientists (Table 7). The recipients of these awards can be found in Appendix E. Table 7. HSF Provincial Personnel Awards Funded () Province(s)/Territory(ies) Program Awards (#) Awards ($) Total ($) British Columbia/Yukon Alberta/Northwest Territories/Nunavut New Investigator Awards 2 120, ,000 Saskatchewan Manitoba Sanofi Canada - Heart and Stroke Foundation, Manitoba Award in Cardiology 1 10,000 Master's Student Award 1 1,000 Dr. Dexter Harvey Award 1 5,000 16,000 Ontario Career Investigator 20 1,618,500 Clinician Scientist 4 300,000 Mid-Career Investigator ,000 Summer Student Scholarship 14 57,000 2,935,500 Quebec New Brunswick Nova Scotia Prince Edward Island Newfoundland and Labrador Graduate Scholarship 1 1,500 Grant - NeuroFIT Program 1 3,500 Keith Griffiths Memorial Scholarship 1 1,500 Undergraduate Nursing Award in Cardiovascular Health 1 1,500 Undergraduate Nursing Award in Stroke 1 1,500 9,500 TOTAL 60 $3,081,000 $3,081,000 15

22 Heart and Stroke Foundation Research Report Description of Provincial Personnel Awards Heart and Stroke Foundation, Alberta/Northwest Territories/Nunavut (HSF,A) New Investigator The New Investigator Awards aim to provide outstanding Alberta investigators in their early career with the opportunity to establish research programs and build teams through provision of a contribution to their group research efforts, laboratories or salary. The intent is to foster research excellence and support retention of outstanding talents in Alberta. This initiative provides salary support to excellent Alberta applicants whose innovative research plans have demonstrated strong potential to deliver impact on the HSF mission. The applicants are expected to demonstrate that their overall research program and plan have a cardio or cerebrovascular focus. Heart and Stroke Foundation, Manitoba (HSF,M) Sanofi Canada Heart and Stroke Foundation, Manitoba Award in Cardiology This $10,000 award is given to stimulate and support excellence in research and scholarly activity in the discipline of Cardiology at the University of Manitoba. The award funds a clinical cardiology resident, preferably in their third year, who demonstrates academic excellence within the clinical residency program, possesses humanistic qualities with respect to patient care, collegiality and interpersonal dealings with medical and paramedical staff, has clinical competence in the field, and is expected to pursue further academic training beyond core cardiology. Master s Student Award This award was established by HSF,M to encourage the training of young investigators in cardiovascular sciences in Manitoba and to recognize the achievements of a student at the Master s level. The award total is $1,000. Dr. Dexter Harvey Award This $5,000 award encourages and supports training for outstanding Master s or PhD students enrolled in a Manitoba university program whose research focuses on primary prevention risk factor reduction in the areas of physical inactivity, excess weight and tobacco smoking. The annual award was named after retired HSF board member, Dr. Dexter Harvey, whose dedication to improving the public health and well-being of Manitobans has been demonstrated through his 30-year commitment as a senior volunteer with the Foundation. Heart and Stroke Foundation, Ontario (HSF,O) Career Investigator Stipend support for up to five years for investigators of national/international stature. Clinician Scientist Phase 1 Stipend support for up to four years, to provide clinician-scientists who are within four years of their first full-time academic appointment with protected time to build influential programs of cardio- or cerebrovascular research. Clinician Scientist Phase 2 Stipend support for up to three years, to provide clinician-scientists within no fewer than four, and no more than eight years since their first full-time academic appointment with protected time to build influential programs of cardio- or cerebrovascular research. Mid-Career Investigator Stipend support for up to four years, to provide investigators within no fewer than 8, and no more than 18 years since their first full-time academic appointment with protected time to build influential programs of cardio- or cerebrovascular research. Summer Student Scholarship: Medical Student Award Stipend support for up to four months for medical students to conduct cardio- or cerebrovascular research with mentorship from established investigators. Heart and Stroke Foundation, Newfoundland and Labrador (HSF,NL) Graduate Scholarship This scholarship, valued at $1,000 per annum, is awarded to a full-time graduate level student in the Faculty of Medicine, who is pursuing a research program related to cardiovascular disease. Keith Griffiths Memorial Heart and Stroke Foundation Graduate Scholarship This scholarship, valued at $1,500 per annum, was established through a generous contribution by the Griffiths family, in memory of their father, Keith Griffiths, a stroke survivor and dedicated volunteer, and in partnership with the Heart and Stroke Foundation. The scholarship is awarded to a full-time graduate level student in the Faculty of Medicine, who is pursuing a research program in stroke or neurological issues related to stroke. Undergraduate Nursing Award in Stroke This scholarship, valued at $1,500 annually, is awarded to an undergraduate student in any year of the Bachelor of Nursing program at the School of Nursing who demonstrates an interest in patient health related to stroke care, have actively volunteered with the Heart and Stroke Foundation and also have met the minimum academic requirements for an award. 16

23 Heart and Stroke Foundation Research Report Undergraduate Nursing Award in Cardiovascular Health This scholarship, valued at $1,500 annually, is awarded to an undergraduate student in any year of the Bachelor of Nursing program at the School of Nursing who demonstrates an interest in cardiovascular health, have actively volunteered with the Heart and Stroke Foundation and also have met the minimum academic requirements for an award. Grant NeuroFIT Program Neurofit is a community-based exercise re-integration initiative for people with major neurological physical and cognitive impairments due to stroke, Multiple Sclerosis, Parkinson s Disease, traumatic brain injury and hereditary neurological diseases. It is the only program of it s kind in Newfoundland and Labrador Other Provincial Initiatives In, the provincial offices funded a wide variety of other research initiatives. Table 8 provides details of these initiatives and a list of recipients can be found in Appendix F. Table 8. Other Provincial Research Initiatives () Province(s)/Territory(ies) Program Awards (#) Awards ($) Total ($) British Columbia/Yukon HSF-UBC Cardiology Research Partnership: Cardiology Academic Practice Plan (CAPP) , ,000 Alberta/Northwest Territories/Nunavut Seed Grants 5 221,500 Bridge Grant 1 70, ,500 Saskatchewan Manitoba Primary Prevention Challenge Grant 2 79,971 79,971 Ontario Bridge Grant 8 560, ,000 Quebec Awards for Excellence in Research 5 50,000 Training Bursaries 2 13,267 63,267 New Brunswick Nova Scotia Dr. Gregory Ferrier Award 1 5,000 BrightRed Graduate Research Award 5 25,000 30,000 Prince Edward Island Newfoundland and Labrador Heart and Stroke Foundation Canadian Partnership for Stroke Recovery - 2,000,000 2,000,000 TOTAL 39 $3,224,738 $3,224,738 HSF contributions to the Canadian Partnership for Stroke Recovery. Description of Other Provincial Research Initiatives Heart and Stroke Foundation, British Columbia/Yukon (HSF,BCY) SF-UBC Cardiology Research Partnership: Cardiology Academic Practice Plan (CAPP) As part of its mandate to support innovative research and its application to improve the health of Canadians, Heart and Stroke Foundation, BC & Yukon, has partnered with the University of British Columbia s Division of Cardiology to support research by early career cardiologists. By providing grant support that will protect the research time of awardees, the academic practice plan will cultivate academic capacity, supporting increased clinical research and education. This will in turn strengthen the recruitment and retention of outstanding early career physicians in British Columbia. Heart and Stroke Foundation, Alberta (HSF,A) Bridge Grant Bridge funding is being offered to an Alberta-based Grant-in-Aid applicant whose funding proposal was ranked highly based on percentile ranking in their scientific review committee, but did not meet the national GIA funding cut-off. The bridge funding can be used to support eligible direct research expenses as per the Foundation s GIA program application guidelines (). 17

24 Heart and Stroke Foundation Research Report Seed Grant Seed Grants provide funding support to New Investigators to conduct research which will lay the groundwork for a new and competitive peer-reviewed application. The intent is to enhance Alberta success in national and provincial granting competitions. This initiative provides opportunity for investigators to develop high-impact novel ideas and encourages innovative research with the potential for significant impact on cardio and/or cerebrovascular health. Heart and Stroke Foundation, Manitoba (HSF,M) Primary Prevention Challenge Grant As part of its commitment to primary prevention research, the Heart and Stroke Foundation, Manitoba allocated funds towards the Primary Prevention Challenge Grant program to support innovate and unique projects that have direct policy and/or practice relevance and application to reducing risk factors at a population level in Manitoba. The program builds on the findings of Making the Case for Primary Prevention: An Economic Analysis of Risk Factors in Manitoba, which clearly demonstrated the need to reduce the prevalence of risk factors for chronic disease which will reduce health care costs and improve population health. Heart and Stroke Foundation, Nova Scotia (HSF,NS) Dr. Gregory Ferrier Award HSF,NS offers an award for excellence in research. This award is given annually to the highest rated HSF,NS Grant-in-Aid recipient in honour of Dr. Gregory Ferrier, an internationally respected, award-winning scientist known for his groundbreaking and innovative research program related to heart failure mechanisms. The award also honours the spirit of Dr. Ferrier s mentorship to a new generation of researchers; he went above and beyond to ensure they were able to conduct their re-search in Nova Scotia. A stipend of $5,000 is awarded to the grant budget in support of student funding in recognition of Dr. Ferrier s commitment to research training. BrightRed Graduate Research Award -- The BrightRed Graduate Research Awards Program recognizes excellent emerging cardiovascular and cerebrovascular researchers in Nova Scotia at differing stages of career development, by providing financial support to students and trainees enrolled in research-based Masters, Doctorate, or Postdoctorate programs at academic institutions in Nova Scotia. Heart and Stroke Foundation, Ontario (HSF,O) Bridge Grant One year, $70,000 bridge funding to Ontario GIA applicants who ranked highly in the national competition, but didn t meet the national funding cut-off. This was a shortterm strategy to support Ontario-based GIA applicants during the transition to the collectively managed GIA program. Heart and Stroke Foundation, Quebec (HSF,Q) Awards for Excellence in Research A number of Awards for Excellence in Research are awarded each year by HSF,Q mostly in partnership with individual and corporate donors. These awards enhance the Grant-in-Aid program and provide additional financial support to Quebec researchers. The awards range from $5,000 to $20,000. Training Bursaries for PhD students in Cardiovascular and Stroke Research Partnership between the Fonds de la recherche du Québec en santé (FRQS) and HSF,Q. The partners offer training bursaries for PhD students working with researchers receiving a Grant-in-Aid from HSF,Q. 18

25 APPENDIX A DIRECTED RESEARCH FUND Photo: Dr. Marilyn MacKay-Lyons (Dalhousie University) is a Heart and Stroke Foundation funded researcher. Tracy Young (right), a stroke patient at the Nova Scotia Rehabilitation Centre is benefiting from research conducted by Dr. Marilyn MacKay-Lyons.

26 Heart and Stroke Foundation Research Report NEW INITIATIVE Operating Grant: Population Health Intervention Research Partner(s): The CIHR Institute of Population and Public Health; HSF. Total Initiative Funding: $400,000 Total HSF Funding: $400,000 Description: The purpose of this initative is to support the prompt initiation of population health intervention research on rapidly unfolding programs, policies and resource distribution approaches that have been initiated by others (e.g., policy makers) and have the potential to impact health and health equity at the population level. Operating Grant: Population Health Intervention Research Principal Investigator(s) Clavier, Carole Kirk, Sara Research Institution Université de Québec à Montreal Dalhousie University Project Co-Investigator(s) Term $ Total $ Total $ HSF (All Partners) HSF Total $ Theme(s) (All Partners) Comparing healthy public policies: Active transportation policies in Montreal and Toronto. Ontario: Poland, Blake; Savan, Beth; Quebec: Bilodeau, Angèle; Divay, Gerard 100, , , ,000 IV Health eating in Alberta: Olstad, 100, , , ,000 IV recreation and sport Dana; Raine, Kim D.; settings. British Columbia: Naylor, Patti-Jean; Nova Scotia: McIsaac (Langille), Jessie-Lee; Rehman, Laurene; Shearer, Cindy L. 20

27 Heart and Stroke Foundation Research Report CONTINUING INITIATIVES Coalitions Linking Action and Science for Prevention 2 (CLASP2) Partner(s): Canadian Partnership Against Cancer; HSF. Total Initiative Funding: $4,697,268 Total HSF Funding: $1,200,000 Description: The CLASP2 initiative is a priority initiative of CPAC. CLASP2 brings together research, practice and policy specialists working across provinces and territories to form multidisciplinary coalitions working to improve the health of Canadians by preventing cancer and chronic disease. Coalitions Linking Action and Science for Prevention 2 (CLASP2) Principal Investigator(s) Collins, Mary Oh, Paul Research Institution BC Healthy Living Alliance Toronto Rehabilitation Institute Project Co-Investigator(s) Term $ Total $ HSF (All Partners) Total $ Total $ Theme(s) HSF (All Partners) Working on Wellness in Strategic Populations (WOW). N/A 200, , ,000 2,297,270 III,IV Activity, Smoking N/A 200, , ,000 2,399,998 III,IV Cessation, Healthy Eating and Alcohol Intervention & Motivation Program (ACCELERATION). Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 21

28 Heart and Stroke Foundation Research Report Canadian Partnership for Tomorrow Project (CPTP) - Canadian Alliance for Healthy Hearts and Minds (CAHHM) Partner(s): Canadian Partnership Against Cancer; HSF. Total Initiative Funding: $15,998,465 Total HSF Funding: $1,999,852 Description: The Canadian Partnership for Tomorrow Project (CPTP) is Canada s largest population health research platform. It contains a wealth of data from more than 300,000 Canadians aged who have volunteered to share information about their health, lifestyle, environment and behaviour over their adult lives. Nearly half of participants have also provided a biological sample. They have done so hoping to help researchers unlock the answers to why some people develop cancer and chronic diseases while others do not. CPTP aims to create a legacy that will benefit both current and future generations by strengthening population research in Canada, by producing excellent evidence to inform health care improvements, and by offering the maximum benefit to the people of Canada and to the health systems on which they rely. CAHHM is a pan-canadian, multi-ethnic cohort (South Asian, Asian and African descent) study which will enroll predominantly healthy men and women between the ages of 35 to 69 years. CAHHM primarily aims to increase our understanding of the impact of the individual, socio-economic and other environmental factors leading to cardiac and vascular disease. The HSF provides support to the overall initiative, and specifically includes an aboriginal component that would otherwise not be included. Canadian Partnership for Tomorrow Project (CPTP) - Canadian Alliance for Healthy Hearts and Minds (CAHHM) Principal Investigator(s) Anand, Sonia S.; Friedrich, Matthias; Tu, Jack Research Institution McMaster University Project Co-Investigator(s) Term $ HSF Total $ (All Partners) Total $ HSF Total $ (All Partners) Theme(s) The Canadian Alliance Alberta: Anderson, 500,000 4,680,872 1,999,852 15,998,465 II, IV for Healthy Hearts Todd; Smith, Eric and Minds. British Columbia: McManus, Bruce Nova Scotia: Blanchard, Christopher Ontario: Jenkins, David; Moody, Alan; Roberts, Bob Quebec: Despres, Jean-Pierre; Tsoukas, Chris 22

29 Heart and Stroke Foundation Research Report CIHR/HSFC Training Awards in Population Intervention for Chronic Disease Prevention: A Pan-Canadian Program Partner(s): CIHR; the Propel Centre for Population Health Impact (at the University of Waterloo); HSF. Total Initiative Funding: $49,000 Total HSF Funding: $75,000 Description: HSF has partnered with the CIHR-funded Propel Centre to support trainee awards in population intervention for chronic disease prevention. The goal of this strategic training program is to increase the capacity for population intervention research in Canada by training students as impact-oriented scientists who work collaboratively across disciplines and sectors to address the most relevant questions using the most appropriate and rigorous methods, to improve population interventions for chronic disease prevention. Doctoral Research Award Awardee Cepeda, Ivan Leonardo Ishikawa, Takuro Prowse, Rachel Research Institution University of British Columbia University of British Columbia University of Alberta Project Supervisor(s) Term $ Total $ Total $ Total $ Theme(s) HSF (All Partners) HSF (All Partners) Impact of physical Masse, Louise; Gotay, activity and healthy Carolyn; McKay, eating in schools on Heather BMI and academic performance. Risky play meets nature Brussoni, Mariana; play: the influence of Masse, Louise; school-based natural Herrington, Susan outdoor play spaces on children's risky play and physical activity. Impact of Raine, Kim; Storey, implementing a Kate community-developed policy to restrict unhealthy food and beverage marketing to children in a recreational sport setting. 20,000 20,000 20,000 20,000 IV 20,000 20,000 20,000 20,000 IV 4,500 4,500 4,500 4,500 IV Master s Studentships Awardee Stefanczyk, Jennifer Research Institution University of Waterloo Project Supervisor(s) Term $ HSF Total $ (All Partners) Total $ HSF Total $ (All Partners) Theme(s) Association between Leatherdale, Scott; 4,500 4,500 4,500 4,500 IV characteristics of the Elliott, Susan; school built environment Faulkner, Guy and obesity: A prospective cohort study of Canadian youth. Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 23

30 Heart and Stroke Foundation Research Report Emerging Network: Canadian Stroke Prevention Intervention Network (C-SPIN) Partner(s): The CIHR Institute of Circulatory and Respiratory Health and the Institute of Aging; HSF. Total Initiative Funding: $18,520,000 Total HSF Funding: $1,000,000 Description: The ultimate goal of an Emerging Network will be to generate new knowledge and bridge gaps between research and outcomes by contributing to one or more of the following: identifying key knowledge gaps, promoting national and international collaborations among scientists from all themes to address those gaps in a coherent fashion by sharing ideas, tools, methods, and scarce resources, accelerating translation of biomedical discoveries into clinical applications and best practices as well as; to the marketplace; developing, validating, and implementing an intervention that changes a significant aspect of practice; and evaluating outcomes to demonstrate impact. The Canadian Stroke Prevention Intervention Network (C-SPIN) stems from the necessity to develop relevant and integrated stroke-prevention strategies to reduce embolic strokes across Canada and address the specific challenges of our population. Emerging Network: Canadian Stroke Prevention Intervention Network (C-SPIN) Principal Investigator(s) Healey, Jeff S.; Sheldon, Robert S. 24 Research Institution McMaster University Project Co-Investigator(s) Term $ HSF Total $ (All Partners) Total $ HSF Total $ (All Partners) Theme(s) Canadian Stroke Alberta: Wilton, 200,000 2,860,000 1,000,000 18,520,000 II Prevention Stephen; Sandhu, 2019 Intervention Network Roopinder; Quinn, (C-SPIN) Francis Russell; McRae, Andrew; Hill, Michael D; Exner, Derek V British Columbia: Krahn, Andrew D.; Andrade, Jason G.; Tang, Anthony S.L. Nova Scotia: Parkash, Ratika Ontario: Whitlock, Richard P; Verma, Atul; Tobe, Sheldon W.; Thabane, Lehana; Sharma, Mukul; Redfearn, Damian Paul P; Nieuwlaat, Robby; Morillo, Carlos A; Meshkat, Nazanin; Ivers, Noah; Hart, Robert; Ha, Andrew C.T.; Graham, Ian D.; Goeree, Ron; Gladstone, David J.; Dolovich, Lisa R; Connolly, Stuart J; Atzema, Clare L.; Dorian, Paul; Birnie, David H Quebec: Talajic, Mario; Philippon, François; Khairy, Paul; Huynh, Thao T; Essebag, Vidal

31 Heart and Stroke Foundation Research Report HSFC/CIHR Chair in Hypertension Prevention and Control Partner(s): CIHR Institute of Circulatory and Respiratory Health; HSF. Total Initiative Funding: $750,000 Total HSF Funding: $375,000 Description: The goal of this strategic initiative is to support a Chair in the area of hypertension research who will focus on improving awareness, prevention and control of hypertension; identifying gaps in knowledge transfer and exchange / knowledge translation from evidence to practice for hypertension prevention and control; and developing and evaluating new policies, programs and interventions aimed at reducing the burden and/or impact of hypertension. HSFC/CIHR Chair in Hypertension Prevention and Control Principal Investigator(s) Campbell, Norm RC Research Institution University of Calgary Operating Grant: Programmatic Grants in Health and Health Equity Partner(s): CIHR Institute of Population and Public Health; Institute of Circulatory and Respiratory Health, Gender and Health; Institute of Neurosciences, Mental Health and Addiction and Institute of Nutrition, Metabolism and Diabetes; The New Brunswick Health Research Foundation and the Ministry of Health and Long-term Care; HSF. Total Initiative Funding: $4,000,000 Total HSF Funding: $100,000 Description: The specific objectives of this initiative are to support programmatic research that contributes new knowledge to improve health and health equity at a population level; support interdisciplinary collaborations that involve researchers and knowledge-users in public health and other sectors in Canada and if appropriate, also with other countries; and faciliate effective knowledge translation approaches that enhance the integration and use of new and existing knowledge to inform decision-making in public health and other sectors. Operating Grant: Programmatic Grants in Health and Health Equity Principal Investigator(s) Katz, Alan; Chateau, Dan; Nickel, Nathan; Burland, Elaine Research Institution University of Manitoba Project Co-Investigator(s) Term $ HSF Total $ (All Partners) Total $ HSF Total $ (All Partners) Theme(s) Prevention and control N/A , , , ,000 II,III,IV of hypertension in Canada. Project Co-Investigator(s) Term $ HSF Total $ (All Partners) Total $ HSF Total $ (All Partners) Theme(s) PATHS Equity for Manitoba: Bolton, , ,000 4,000,000 III,IV Children: A program James; Chartier, of research into what Mariette; Doupe, works to reduce the Malcolm; Finlayson, gap for Manitoba s Greg; Fransoo, children. Randy; Katz, Laurence; Lix, Lisa; McGavock, Jon; Metge, Colleen; Raymond, Colette; Roos, Les; Roos, Noralou; Santos, Rob; Smith, Mark USA: Jutte, Doug Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 25

32 Heart and Stroke Foundation Research Report Clinical Imaging Team Grants 2009 Partner(s): CIHR Institute of Circulatory and Respiratory Health; HSF. Total Initiative Funding: $4,755,000 Total HSF Funding: $1,250,000 Description: This strategic initiative seeks to address the critical steps between technology development and clinical implementation. The aim is to build an integrated platform that brings together Canadian and international strengths in imaging technology, molecular targeting strategies, and policy-relevant outcome trials that examine new, innovative clinical imaging applications. It is anticipated that the program will encourage the identification of novel non-invasive imaging strategies and novel imaging biomarkers, demonstration of their potential through clinical implementation, and evaluation of their diagnostic and prognostic use. HSF co-funds two of the four Team Grants supported through the initiative; both of which are in the area of stroke. Clinical Imaging Team Grants 2009 Principal Investigator(s) Nichol, Helen; George, Graham Sawan, Mohamad Research Institution University of Saskatchewan École Polytechnique de Montréal Project Co-Investigator(s) Term $ Total $ HSF (All Partners) Total $ Total $ Theme(s) HSF (All Partners) CIHR/HSFC team in Saskatchewan: Synchrotron medical Chapman, Dean; imaging. Kelly, Michael; Paterson, Phyllis G.; Pickering, Ingrid; Thomlinson, William; Wiebe, Sheldon. Alberta: Colbourne, Frederick. Ontario: Haacke, Ewart M. USA: Guzman, Raphael. A portable wireless Quebec: Béland, near infrared Renée; Denault, spectroscopy system André Y.; combined with electroencephalography Lanthier, Sylvain; Deschamps, Alain; for bedside monitoring Lassonde, Maryse; of stroke and cardiac Lesage, Frédéric; patients. Nguyen, Dang; Tardiff, Jean-Claude , ,500 2,395,000 I,II , ,500 2,360,000 I,II,III,IV 26

33 Heart and Stroke Foundation Research Report Resuscitation Outcomes Consortium (ROC) Renewal 2009 Partner(s): US National Institutes of Health - National Heart, Lung and Blood Institute; CIHR Institute of Circulatory and Respiratory Health; HSF. Total Initiative Funding: $7,667,600 Total HSF Funding: $3,000,000 Description: ROC is the first large-scale effort to conduct clinical trials in sudden cardiac arrest and severe traumatic injury focusing on interventions by Emergency Medical Services teams in the field, when there is optimal potential for patient benefit. The goal is to improve survival rates from sudden cardiac arrest and severe traumatic injury. The renewal of the Consortium, through a competitive process, ensures continued support for the ten regional Clinical Centres and one Data and Coordinating Centre in the U.S. and Canada. This is much needed infrastructure for the rapid translation of research advances into improved resuscitation outcomes. HSF co-funds the two Canadian sites listed below. Resuscitation Outcomes Consortium (ROC) Renewal 2009 Principal Investigator(s) Morrison, Laurie J.; Dorian, Paul; Slutsky, Arthur Stiell, Ian G. Research Institution St. Michael's Hospital Ottawa Hospital Research Institute Project Co-Investigator(s) Term $ Total $ Total $ Total $ Theme(s) HSF (All Partners) HSF (All Partners) Toronto regional Ontario: Black, resuscitation research Sandra E.; Davis, out of hospital network. David; Hutchison, James S.; Lavery, James; Redelmeier, Donald A.; Rotstein, Ori D.; Sibbald, William. ROC Ottawa Ontario: Herbert, OPALS/BC. Paul C.; Osmond, Martin H.; Vaillancourt, Christian; Wells, George A. British Columbia: Abu-Laban, Riyad B.; Christenson, James A.; Macnab, Andrew J.; Russell, James A.; Simons, Richard K.; Sun, Charles Y , ,360 1,500,000 3,509,800 I,II,III , ,360 1,500,000 4,157,800 II,III,IV Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 27

34 Heart and Stroke Foundation Research Report 28

35 Heart and Stroke Foundation Research Report APPENDIX B NATIONAL PERSONNEL AWARDS Photo: Dr. Thomas Claydon (Simon Fraser University) was the recipient in of a Grant-in-Aid. 29

36 Heart and Stroke Foundation Research Report Doctoral Research Awards Awardee Supervisor(s) Research Institution Adnan, Areeba Turner, York University Gary R. Duchemin, Sonia Girouard, Université de Hélène Montréal Smith, Kurt J. Ainslie, Philip University of British Columbia Sun, Yao Zehr, E. Paul University of Victoria Vasquez, Anderson, Baycrest Brandon P. Nicole D. Centre for Geriatric Care Project Keywords Term $* Total $* Theme(s) A brain-based approach Aging, goal to enhancing executive management training, control in multi-modal mild multi-modal mild cognitive impairment. cognitive impairment, rehabilitation, cerebrovascular health. Étude du rôle de Hypertension, l'inflammation induite angiotensine II, débit par l'angiotensine II sur sanguin cérébral, l'intégrité de l'homéostasie fonctions cérébrales, et des fonctions cérébrales. inflammation. Cerebrovascular functioning Cerebral blood flow, following acute and chronic prostaglandins, aging. administration of selective versus non selective nonsteroidal anti-inflammatory treatment. Improving efficiency and Rehabilitation, strength efficacy of unilateral strength training, interlimb, training after stroke. cross-education, spasticity. Utility of attention training Small vessel stroke, for response time variability intraindividual variability, in small vessel stroke. cognitive training. Focus on Stroke Doctoral Research Awards Awardee Supervisor(s) Research Institution Barss, Zehr, E. Paul University of Trevor S. Victoria Chauvet, Cristina Deng, Alan Y. CHUM Project Keywords Term $ Total $ Total $ Total $ Theme(s) HSF* (All Partners)* HSF* (All Partners)* ,500 63,000 II 21,000 21,000 I 21,000 24,500 I,II 21,000 63,000 I,II 21,000 21,000 II Can strength training the less affected arm improve the more affected arm? Post-stroke rehabilitation, resistance training, neuromuscular plasticity, cross-education, electromyography. 21,000 21,000 36,750 43,750 I,II Alpha-Kinase 2 is Hypertension, ,000 21,000 63,000 63,000 I,II a novel candidate cardiovascular gene for inherited disease, hypertension in congenic strains, Dahl rats. QTL, candidate genes. These awards have been partnered with CIHR Institute of Circulatory and Respiratory Health and Institute of Aging and/or Canadian Stroke Network. * Amount shown represents stipend value only. 30

37 Heart and Stroke Foundation Research Report Awardee Supervisor(s) Research Institution Edel, Pierce, St. Boniface Andrea Grant N.; G.H. Aliani, Research Michel Centre Eftekhar, Parvin Hammad, Maha Brooks, Dina; Mochizuki, George Corbett, Dale R. Ferguson, Stephen University of Toronto University of Ottawa Robarts Research Institute Klarner, Zehr, E. Paul University of Taryn Victoria Kwan, Donna Rosenbaum, R. Shayna York University Project Keywords Term $ Total $ Total $ Total $ Theme(s) HSF* (All Partners)* HSF* (All Partners)* 3,500 3,500 21,000 21,000 I,II 21,000 21,000 53,000 63,000 II Gomez- Smith, Mariana Ground flaxseed therapy in the treatment of hypertensive Hypertension, stroke, flaxseed, clinical, bioanalysis. patients. Examining the Stroke, upper effectiveness limb function, of combined botulimun toxin, rehabilitation rehabilitation. and botulinum toxin injection on functional improvement of the upper limb after stroke. Impact of cafeteria Stroke, metabolic diet induced syndrome, inflammation on cerebrovasculature, brain vasculature MRI, and stroke two-photon outcome. microscopy. Regulation G Proteinof signal Coupled transduction Receptors, Signal of angiotensin Transduction, receptor in phospholipase vascular smooth Cδ1, muscle cells. Cardiovascular Disease, Vascular Smooth Muscle Cells. Can arm and leg Walking, training cycling training intervention, improve walking neuromuscular ability after adaptation, stroke? motor recovery, spasticity. Searching for Frontal stroke, impaired and episodic future preserved futureoriented thought, cognitive decision-making, processes in focal neuroeconomics. frontal stroke survivors ,000 21,000 63,000 63,000 I,II 3,500 3,500 8,750 21,000 I,II 17,500 17,500 42,500 52,500 I,II,III 21,000 21,000 29,750 42,000 I,II These awards have been partnered with CIHR Institute of Circulatory and Respiratory Health and Institute of Aging and/or Canadian Stroke Network. Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 31

38 Heart and Stroke Foundation Research Report Awardee Supervisor(s) Research Institution Liu, Sam Nolan, University of Robert P. Toronto Malik, MacVicar, University Aqsa Brian of British Columbia Mullick, Levin, McGill Aditi A. Mindy; University Fung, Joyce Patten, Slack, University of David Ruth S. Ottawa Rabin, Rosenbaum, York Jennifer S. R. Shayna University Simpson, Eng, University Lisa Janice J. of British Columbia Svoboda, Slack, University of Devon Ruth S. Ottawa Zurek, Orser, University of Agnieszka Beverley Toronto A. Project Keywords Term $ Total $ Total $ Total $ Theme(s) HSF* (All Partners)* HSF* (All Partners)* Expert- vs. userdriven lifestyle e-counselling to reduce stroke risk in hypertension. Web-based intervention, cardiovascular disease prevention, behavioural modification. Mitochondrial Spreading modulation of depression, glutamate release oxidative stress, and cell death glutamate during spreading release, depression. presynaptic NMDARs, mitochondrial dysfunction. Mechanisms of Motor recovery, motor recovery stroke, reaching, and arm use obstacle in people with avoidance, stroke. cognition. The role of OPA1 Stroke, in mitochondrial mitochondria, function and starvation, OPA1, neuronal survival. cristae. An fmri Stroke, investigation autobiographical of mental state memory, theory attributions in of mind, fmri, stroke patients. neuropsychology. Upper extremity Stroke, rehabilitation neuroplasticity, interventions arm use, RCT, in stroke: fmri. investigating associated changes in arm use and brain activation. The role of Axon guidance, retinoblastoma regeneration, protein in axon neural guidance and circuits, stroke stroke recovery. rehabilitation. Treatment of Memory, memory deficits ischemia, after stroke. inflammation, GABA (A) receptors. 21,000 21,000 31,500 42,000 II,III 21,000 21,000 26,250 42,000 I 21,000 21,000 53,000 63,000 I,II 3,500 3,500 8,750 24,500 I ,500 3,500 42,000 42,000 I,II ,500 17,500 28,000 28,000 II 3,500 3,500 8,750 24,500 I 10,500 10,500 15,750 29,750 I,II These awards have been partnered with CIHR Institute of Circulatory and Respiratory Health and Institute of Aging and/or Canadian Stroke Network. * Amount shown represents stipend value only. 32

39 Heart and Stroke Foundation Research Report Research Fellowships Awardee Supervisor(s) Research Institution Arcand, JoAnne L'Abbe, Mary University of R.; Manuel, Toronto Douglas G. Bernier, MacVicar, University Louis-Philippe Brian A of British Columbia Brazeau, Dasgupta, McGill Anne-Sophie Kaberi University Care, Alison, S. Davidge, University of Sandra Alberta Chaudhary, Ketul Stewart, Ottawa Duncan Hospital Research Institute Cheng, Yen M. Claydon, Simon Fraser Thomas University Das, Samir Van Petegem, University Filip of British Columbia Dason, Jeffrey Sokolowski, University of Marla B. Toronto Dyson, Hoge, Rick Université de Kenneth S. Montréal Edwards, Jodi D. Black, S Sunnybrook andra E. Research Institute Project Keywords Term $* Total $* Theme(s) Sodium and cardiovascular disease: a food supply and population health model to evaluate the benefits of Nutrition, diet, sodium, potassium, heart failure, food records, urine collections. Canada's sodium reduction strategy. Mechanisms of ATP ATP signalling, microglia, release from pyramidal pannexin, ischemia, neurons in stroke-induced glutamate excitotoxicity. excitotoxicity. Does shared-diabetes risk Prediabetes, insulin imply 'shared' screening and resistance, cardiovascular 'shared' health behaviour risk factors, physical change? activity, eating behaviours. Effect of advanced maternal Maternal age, age on subsequent maternal aging, endothelium, and offspring cardiovascular cardiovascular, cardiac health. function. Vascular progenitor and Vasculature, stem cells, stem cells for optimal vascular progenitor cells, revascularization of acellular endothelium, organ lung scaffolds. regeneration. Molecular determinants herg channels, long QT of the unique voltagedependent syndrome, voltage-clamp gating of herg fluorometry, channel channels. physics, channel gating. Sodium channel beta Sodium channel, subunits: structure and membrane protein, function in native and X-ray crystallography, diseased states. cardiovascular disease, disease mutation. The role of PKG activity in Drosophila melanogaster, synaptic transmission and synaptic transmission, food related behaviours. cgmp, PKG, feeding behaviour. MRI characterization of Neurovasculature, mri, neurovascular function in carotid artery disease, carotid artery disease. cognitive function. Relationship between Post-stroke dementia, amyloid burden and covert small vessel cognitive impairment in disease, transient periventricular white matter ischemic attack, beta disease. amyloid, amyloid PET imaging , ,000 IV ,667 95,000 I 40, ,000 II,III,IV 20,000 60,000 I 40,000 80,000 I , ,000 I 40,000 80,000 I ,000 80,000 I 40,000 80,000 I,II 33,333 80,000 I,II,IV Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 33

40 Heart and Stroke Foundation Research Report Awardee Supervisor(s) Research Institution Eny, Karen M. Paterson, Hospital for Andrew D. Sick Children Esseltine, Jessica Laird, Dale W. University of Western Ontario Freeman, Grinstein, Hospital for Spencer A. Sergio Sick Children Gifford, Jessica L. Young, University of Howard S. Alberta Hamza, Dyck, Jason University of Shereen M. R.B. Alberta Hayward, Kathryn Boyd, Lara A. University of British Columbia Klaiman, Regnier, University of Jordan M. Michael Washington Lalu, Manoj Stewart, Ottawa Mathew Duncan Hospital Research Institute Lively, Starlee Schlichter, Toronto Lyanne C. Western Research Institute Ludke, Ana Li, Ren-Ke University Health Network Project Keywords Term $* Total $* Theme(s) Diet, genetics, and cardiovascular disease risk factors in subject with Type 1 Diabetes. Nutrition, genetics, cardiovascular disease, CVD risk factors, genome-wide association study. Mechanisms linking Cx43 Diabetic hypertension, gene mutations causing A-kinase anchoring oculodentodigital dysplasia protein, protein kinase-c, to cardiac disease. vasoconstrictor-mediated hypertension, signal transduction. The role of Class B Atherosclerosis, scavenger receptors in the inflammation, innate immune response macrophages, scavenger controlling atherosclerosis. receptors. Molecular insights into Heart failure, hereditary hereditary forms of heart mutations, cardiac failure. muscle, sarcoplasmic reticulum, calcium transport. Role of fatty acid translocase Obesity, cardiac CD36 in cardiac dysfunction dysfunction, in vivo, FAT/ associated with obesity. CD36, lipotoxicity. Characterisation of the Stroke, upper limb, structural and functional neuroimaging, severe, capacity to recovery after dose. severe stroke. Investigation of 2-deoxy-ATP Dilated cardiomyopathy, as a treatment for dilated 2-deoxy-ATP (datp), cardiomyopathy. muscle biomechanics, myofilament targeted therapy. Therapeutic effects Sepsis induced and mechanisms of cardiac dysfunction, mesenchymal stromal cell mesenchymal stromal conditioned medium in cells, exosomes. sepsis. Innate inflammation and Ischemic stroke, white-matter damage after hemorrhagic stroke, ischemic and hemorrhagic inflammation, microglia, stroke. white matter injury. Role of interleukin-10 Angiogenesis, in uterine stem cell myocardial ischemia, differentiation and cell transplantation, preservation of cardiac cytokines, cell culture. function after myocardial infarction , ,708 I,II 26,195 66,195 I 40,000 80,000 I 40,000 40,000 I,II 40,000 80,000 I 20,000 80,000 I,II 36,667 80,000 I 37, ,000 I ,667 80,000 I 40, ,000 I * Amount shown represents stipend value only. 34

41 Heart and Stroke Foundation Research Report Awardee Supervisor(s) Research Institution Manickaraj, Ashok Mital, Seema Hospital for Kumar Sick Children Marnane, Michael Hsiung, University Ging-Yuek of British Robin; Columbia Mackenzie, Ian R. A. McNeill, Brian Suuronen, University of Erik Ottawa Heart Institute Menzies, Keir J. Auwerx, École Johan polytechnique Fédérale de Lausanne (EPFL) Munce, Bayley, Toronto Sarah E. P. Mark T Rehabilitation Institute Parajuli, Nirmal Dyck, Jason University of R.B. Alberta Patel, Vaibhav B. Oudit, Gavin University of Alberta Pezeshki, Adel Chelikani, Prasanth University of Calgary Pillon, Nicolas J. Klip, Amira Hospital for Sick Children Shah, Amin Davidge, University of Sandra T. Alberta Project Keywords Term $* Total $* Theme(s) Exome sequencing for RV remodeling after tetralogy of fallot repair. Gene variations, tetralogy of fallot repair, right ventricular remodeling, whole exome sequencing. Pathologic study of the role Mixed, vascular, of cerebrovascular disease in Alzheimers, dementia, mixed Alzheimer dementia. pathology. Enhancing cell therapy using Progenitor cells, cell a protein modified collagen therapy, revascularization, matrix. collagen matrix. The role of the corepressor Metabolic homeostasis, protein SMRT/NCoR2 in mitochondria, metabolic homeostasis. corepressors, transcriptional control, high fat diet. Quality improvement Systematic review, strategies in post-stroke meta-analysis, stroke, care. quality improvement, quality of life. Understanding heart failure Ischemia reperfusion and the development of new injury, cardiac therapies. remodelling, myocardial infarction, preconditioning, signaling. Role of ACE2 in Diabetic cardiomyopathy, diabetic cardiovascular systolic dysfunction, complications: enhancing ACE2, angiotensin II, db/ ACE2 as potential therapy. db model. Bariatric surgeries for Bariatric surgery, obesity, obesity: mechanisms of cardiovascular function, action on cardiovascular metabolism. function and metabolism. Crosstalk between Diabetes, obesity, monocytes and endothelial inflammation, saturated cells in a high fat fatty acids, immune environment. system. Mechanism and Intrauterine growth sustainability of resveratrol restriction, western to improve cardiovascular diet, oxidative stress, and metabolic function. resveratrol, cardiovascular function. 40,000 80,000 I,II 40,000 80,000 II 40,000 80,000 I 40,000 80,000 I 40,000 66,667 III 40,000 80,000 I,II 40,000 80,000 I,II 40,000 80,000 I 33,333 33,333 I 40,000 80,000 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 35

42 Heart and Stroke Foundation Research Report Awardee Supervisor(s) Research Institution Singer, Mochizuki, Sunnybrook Jonathan C. George Research Institute Smyth, David C. Liu, Peter P. University of Ottawa Heart Institute Subramanian, Feldman, Université de Sandeep Anatol; Montréal Barthélemy, Dorothy Sun, Bo Chen, S.R. University of Wayne Calgary Tian, Xixi Backx, Peter University of H.; Dorian, Toronto Paul Titterness, Wang, Yu University Andrea Tian of British Columbia Van Hulst, Paradis, McGill Andraea Gilles; University Henderson, Melanie Voss, Christine McKay, University Heather A.; of British Winters, Columbia Meghan Yang, Kai MacVicar, University Brian of British Columbia Zarruk Serrano, David, McGill Juan Guillermo Samuel University Project Keywords Term $* Total $* Theme(s) Neuromechanical mechanisms of balance dyscontrol among Stroke, spasticity, balance, dynamic stability, neuromechanics. individuals with post-stroke lower limb spasticity. IRF9 in heart failure Immunology, progression: investigation atheroscelerosis, of IRF9 as a remodeling B lymphocytes, regulator and putative inflammation, clinical biomarker. hematopoiesis. Reaching after stroke: role Arm-trunk coordination, of arm-trunk coordination stroke, transcranial and anticipatory postural magnetic stimulation, adjustments. upper limb, anticipatory postural adjustments. Mechanism and treatment Cardiac alternans, of ryanodine receptorassociated ventricular fibrillation, cardiac alternans. sarcoplasmic reticulum, intracellular calcium release, ryanodine receptors. Understanding the Atrial fibrillation, mechanism of atrial alternans, exercise, fibrillation. hypertension, TNF-alpha. Pathological long-term Plasticity, hippocampus, depression following focal ischemia, AMPA receptor, ischemia promotes CA1 cell long-term depression. death. Determinants of Cardiovascular disease, cardiovascular disease risk stroke, health behaviours, factors among youth with primary/secondary type-1 diabetes. prevention, intervention study. Does neighbourhood matter Physical acitivy, built for children's and youths' environment, child, physical activity and active adolescent, health transport? promotion. The activation of pannexin Pannexin, cell swelling, by cell swelling. edema. Role of TNF-alpha and Neuroinflammation, IFn-gamma in macrophage macrophage polarization, polarization after transient neuroprotection, transient brain ischemia. ischemic stroke. 20,000 20,000 I,II 35,379 75,379 I 40,000 80,000 I,II 40,000 80,000 I 40,000 80,000 I ,457 80,791 I 10,000 10,000 II,III,IV 31,667 71,667 IV 40,000 80,000 I 40,000 80,000 I * Amount shown represents stipend value only. 36

43 Heart and Stroke Foundation Research Report Focus on Stroke Research Fellowships Awardee Supervisor(s) Research Institution Dash, Lewis, Gary Toronto Satya General Hospital DePaul, Vincent G. D'Esterre, Christopher D. Eroume A. Egom, Emmanuel Guzman Lenis, Monica S. Kannangara, Timal S. Lakhani, Bimal McIlroy, William Frayne, Richard; Menon, Bijoy K. Rose, Robert A. Prado, Marco A.M. Lagace, Diane; Béïque, Jean-Claude Boyd, Lara A. McMaster University Foothills Medical Centre Dalhousie University Robarts Research Institute University of Ottawa University of British Columbia Project Keywords Term $ Total $ Total $ Total $ Theme(s) HSF* (All Partners)* HSF* (All Partners)* The role of glucagon like peptide 2 in intestinal Dyslipidemia, atherosclerosis, insulin resistance, GLP-2, ApoB. lipoprotein metabolism in humans. The need Stroke, for speed: balance, gait, training rapid physiotherapy, compensatory reactive control. balance reactions after stroke. Prognostic ability Ischemia, of CT perfusion hemorrhage, CT parameters for perfusion, bloodbrain-barrier acute ischemic stroke. permeability, acute infarct. Effects of Sinoatrial node, natriuretic electrophysiology, peptides on heart electrocardiography, rate and sinoatrial hypertrophy, node function in heart failure. heart disease. The role of striatal Cholinergic cholinergic system, striatum, neurotransmission VAChT, MCAO, in ischemic stroke. nachr alpha-7. Modifying Neurogenesis, cell-intrinsic stroke recovery, excitability electrophysiology, to promote viral gene neurogenesis transfer, during stroke optogenetics. recovery. Structural and Stroke, functional rehabilitation, correlates of imaging, myelin, neuroplastic motor learning. change associated with stroke. 50,000 50,000 76,567 91,667 I ,000 50, , ,167 II 40,000 40,000 41,700 80,000 II ,667 6,667 80,000 80,000 I ,000 10,000 90,000 90,000 I 35,000 35,000 45,000 75,000 I 40,000 40,000 53,400 80,000 I,II These awards have been partnered with CIHR Institute of Circulatory and Respiratory Health and Institute of Aging and/or Canadian Stroke Network. Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 37

44 Heart and Stroke Foundation Research Report Awardee Supervisor(s) Research Institution Miller, Garland, S. University Kimberly J. Jayne of British Columbia Phillips, Ainslie, University Aaron A. Philip of British Columbia Okanagan Stobart, Weber, University of Jillian L. Bruno Zurich Research Scholarships Awardee Mentor(s) Research Institution Schmoelzer, Cheung, Royal Georg M. Po-Yin Alexandra Hospital Project Keywords Term $ HSF* Total $ (All Partners)* Total $ HSF* Total $ (All Partners)* Theme(s) Fast muscle Balance, stroke, 50,000 50, , ,000 I,II activation and rehabilitation, stepping training exercise, electromyography. to improve balance and mobility post-stroke. Cerebrovascular Orthostatic 40,000 40,000 57,000 80,000 I,II control in high hypotension, level spinal cord stroke, spinal injury during cord injury, orthostatic cerebral blood challenge. flow. Characterization Micro-stroke, 40,000 40,000 80,000 80,000 I of astrocyte astrocytes, calcium cerebral blood signalling during flow, calcium, neurovascular functional coupling before imaging. and after ischemia. Project Keywords Term $* Total $* Theme(s) Sustained inflations during chest Neonatal resuscitation, 45,000 90,000 I,II compression to improve chest compression, survival during resuscitation of sustained inflation, newborn asphyxiated newborns. infants, asphyxia. These awards have been partnered with CIHR Institute of Circulatory and Respiratory Health and Institute of Aging and/or Canadian Stroke Network. * Amount shown represents stipend value only. 38

45 Heart and Stroke Foundation Research Report Focus on Stroke Research Scholarships Awardee Mentor(s) Research Institution Patterson, Brooks, University of Kara K. Dina Toronto New Investigators Auger-Messier, Mannix Université de Sherbrooke Préservation de la contractilité et de la structure des cardiomyocytes dans l'insuffisance cardiaque. Insuffisance cardiaque, contractilité, sarcomere, dual-specificity phosphatases (DUSP), ArfGAP with dual PH domains (ADAPs). Carrier, Marc Ottawa Hospital Screening for occult cancer in Venous thromboembolism, Research Institute patients with unprovoked venous unprovoked thrombosis, thromboembolism. deep vein thrombosis, pulmonary, randomized controlled trial. Claydon, Victoria E. Simon Fraser Cerebrovascular control following Blood pressure, cerebral University spinal cord injury. autoregulation, spinal cord injury, autonomic dysreflexia, orthostatic hypotension. Dowlatshahi, Ottawa Hospital Predicting intracerebral Intracerebral hemorrhage, Dariush Research Institute hemorrhage expansion using stroke, CT-angiography, the dynamic CT-angiography hematoma expansion, spot sign. critical care. Girouard, Hélène Université de Mechanisms underlying Neurovascular coupling, Montréal neurovascular coupling angiotensin, astrocytes, dysfuncton in hypertension. calcium, parenchymal arteries. Khan, Zia A. University of Vascular stem cells in diabetic Endothelial cells, stem Western Ontario complications. cells, vasculogenesis, angiogenesis, diabetes. Kirton, Adam University of Modulation of brain plasticity after Perinatal stroke, cerebral Calgary perinatal stroke. palsy, neuroplasticity, transcranial magnetic stimulation, clinical trial. Project Keywords Term $ HSF* Total $ (All Partners)* Total $ HSF* Total $ (All Partners)* Theme(s) An investigation Stroke, motor 45,000 45,000 56,250 90,000 I,II of novel learning, gait. approaches to the neurorehabilitation of post-stroke gait. Awardee Research Institution Project Keywords Term $* Total $* Theme(s) Atzema, Clare L. Institute for Clinical Evaluative Sciences Atrial fibrillation in the emergency room: The AFTER study. Atrial fibrillation, emergency department, health services, clinical decision rule, arrhythmia , ,000 II,III,IV , ,000 I , ,000 II,III,IV , ,000 I,II 60, ,000 I,II , ,000 I , ,000 I , ,000 I,II These awards have been partnered with CIHR Institute of Circulatory and Respiratory Health and Institute of Aging and/or Canadian Stroke Network. Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 39

46 Heart and Stroke Foundation Research Report Awardee Research Institution Project Keywords Term $* Total $* Theme(s) Lagace, Thomas A. University of Regulation of circulating Low-density lipoprotein , ,000 I Ottawa Heart Institute low-density lipoprotein cholesterol levels. receptor, PCSK9, cholesterol, protein-protein interaction, epidermal growth factor-like domain. Larrivée, Bruno Université de Targeting BMP signaling for Angiogenesis, 60, ,000 I Montréal the treatment of cardiovascular complications of diabetes. vascular biology, cell signalling, blood vessel morphogenesis, diabetes Proctor, Spencer D. University of Mechanisms that accumulate Atherogenesis, , ,000 I Alberta apob48-remnant lipoproteins in arterial tissue by proteoglycans during atherogenesis and insulin-resistance. chylomicrons, proteoglycans, insulinresistance, apolipoproteins. Rose, Robert A. Dalhousie Natriuretic peptides regulate Natriuretic peptide, 75, ,000 I University sinoatrial node function and arrhythmogenesis in heart disease. sinoatrial node, electrophysiology, arrhythmias, ion channels Schweizer, Tom A. St. Michael's Cognitive, functional and Aneurysm, subarachnoid , ,000 I,II Hospital neuroimaging profiles of aneurysmal subarachnoid hemmorhage. hemmorhage, cognitive function, functional outcome, neuroimaging. Simpson, Jeremy A. University of Myocardial production of Cardiac, cytokines, 60, ,000 I Guelph erythropoietin and hemoglobin variants. hemoglobin, heart failure, erythropoietin, rodent Stickland, University of Carotid chemoreception and Sympathetic nerve activity, , ,000 I,II Michael K. Alberta sympathetic nervous activity in chronic obstructive pulmonary disease. vascular regulation, chemosensitivity, exercise, lung disease. Swartz, Richard H. Sunnybrook DOC: screening depression, OSA, Stroke prevention, vascular 75, ,000 II,III,IV Health Sciences Centre and cognition to identify high-risk stroke clinic patients. risk factors, vascular cognition, cognitive impairment, post-stroke depression, obstructive sleep apnea Zheng, Xiufen Lawson Health Research Institute The role of toll-like receptors in intima thickening of vein graft in coronary artery bypass grafting. Toll like receptor, toll like receptor 4, coronary artery bypass grafting (CABG), intima thickening, sirna , ,000 I * Amount shown represents stipend value only. 40

47 Heart and Stroke Foundation Research Report Distinguished Clinician Scientist Awardee Research Project Keywords Term $ Total $ Total $ Total $ Theme(s) Institution HSF* (All Partners)* HSF* (All Partners)* McMurtry, Michael Sean University of Alberta Vascular metabolism and angiogenesis. Endothelium, metabolism, arteriogenesis, angiogenesis peripheral arterial disease ,000 75, , ,000 I Saposnik, Gustavo St. Michael's Hospital Efficacy of virtual reality exercises using Wii gaming technology in stroke rehabilitation: a multicentre randomized clinical trial (EVEREST multicentre). Stroke, clinical trial, outcomes research, virtual reality, rehabilitation ,000 75, , ,000 I,II,III Wijeysundera, Harindra C. Sunnybrook Research Institute Evaluating therapeutic decision-making, outcomes and resource utilization in chronic stable angina: an interprovincial population-based study. Agina, quality of life, health care costs, variation in care, administrative database ,000 75, , ,000 II,III,IV Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 41

48 Heart and Stroke Foundation Research Report Industry-Supported Research Fellowship Awards The HSF wishes to thank Pfizer for their generous contributions to support the HSF Research Fellowship Program. Industry-Supported Research Fellowship Awards Awardee Supervisor(s) Research Institution Kwiatkowska, Anna Day, Robert Université de Sherbrooke Maxson, Grinstein, Hospital for Michelle Sergio Sick Children Project Keywords Term $ Total $ Total $ Total $ Theme(s) HSF* (All Partners)* HSF* (All Partners)* Development of Hypercholesterolemia, PCSK9 peptide-based PCSK9 inhibitors inhibitors, for the treatment protein-protein of hypercholesterolemia. anexxin A2, H/ interactions, DX-MS. The role of SCARB1, scavenger cholesterol receptor SCARB1 transport, HDL, in the transport of edocytosis, cholesterol and cardiovascular in cardiovascular health. health. - 36,667 40,000 80,000 I 40,000 40,000 60, ,000 I,II * Amount shown represents stipend value only. 42

49 APPENDIX C GRANTS-IN-AID Photo: Dr. Neale Ridgway (Dalhousie University) was the recipient in of a Grant-in-Aid.

50 Heart and Stroke Foundation Research Report British Columbia/Yukon Principal Investigator and Co-Investigator(s) Andrade, Jason; Tang, Anthony; Wells, George Brown, Craig; Nashmi, Raad Claydon, Thomas Claydon, Victoria; Sanatani, Shubhayan; Kwon, Brian Clee, Susanne Fedida, David Garland, S. Jayne; Bryant, Dianne; Hunt, Michael Hoodless, Pamela Karsan, Aly Research Institution Project Keywords Term $ Cumulative Theme(s) $ to University of British Columbia Double short vs standard exposure duration during cryoballoon pulmonary vein isolation: the DOSE study. Atrial fibrillation, catheter ablation, cryoablation. University of A role for alpha-4 nicotinic Stroke recovery, nicotinic Victoria acetylcholine receptors in receptors, GABA, cortical regulating stroke recovery. plasticity, imaging. Simon Fraser Molecular mechanisms of herg Electrophysiology, voltage University potassium channel gating and clamp fluorimetry, ion drug binding studied using channels, herg, cardiac voltage clamp fluorimetry. excitation. Simon Fraser Cardiovascular autonomic control Cardiovascular autonomic University in acute spinal cord injury. control, spectral analysis, arrhythmia, spinal cord injury, blood pressure. University of Identification of novel genes Obesity, positional cloning, British Columbia affecting body weight. mouse genetics, food intake, metabolism. University of Identification and characterization Heart, potssium channels, British Columbia of molecular interactions repolarization, unnatural between the subunits of the amino acid, mutagenesis. cardiac repolarizing current, IKs, studied using unnatural amino acid mutagenesis and mass spectrometry. University of Effectiveness of fast muscle Balance, stroke, British Columbia activation and stepping training rehabilitation, exercise, (FAST) on balance and mobility electromyography. post-stroke. BC Cancer Regulatory networks in heart valve Embryogenesis, Agency formation. atrioventricular canal, valve development, genomics. BC Cancer Mechanisms of vascular Transcription factors, meis1, Agency development. hemogenic endothelium, vascular endothelium, gene-targeted mouse. 80, ,169 II 86, ,338 I , ,057 I 22,711 51,612 I,II 98,768 98,768 I 87,031 87,031 I , ,656 I,II 100, ,983 I 93,000 93,000 I 44

51 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Krahn, Andrew D.; Sanatani, Shubhayan; Birnie, David; Hamilton, Robert; Dube, Marie-Pierre; Arbour, Laura; Talajic, Mario; Gollob, Michael; Chauhan, Vijay; Gardner, Martin; Gow, Robert; Healey, Jeff; Simpson, Christopher; Lettre, Guillaume; Gerull, Brenda; Klein, George; Chakrabarti, Santabhanu Krahn, Andrew D.; Arbour, Laura; Bennett, Matthew; Gardner, Martin; Gerull, Brenda; Hamilton, Robert; Healey, Jeff; Klein, George; Laksman, Zachary; Sanatani, Shubhayan; Spears, Danna; Talajic, Mario Madden, Kenneth; Meneilly, Graydon McKay, Heather; Macdonald, Heather; Naylor, Patti-Jean; Paez, Antonio; Winters, Meghan; Sims-Gould, Joanie; Nettlefold, Lindsay; Voss, Christine Research Institution Project Keywords Term $ Cumulative Theme(s) $ to University of British Columbia CASPER: Canadian genetic heart rhythm network. Arrhythmia, electrophysiology, cardiology, genetics, sudden death. University of National long QT syndrome Long QT syndrome, genetics, British Columbia registry and BioBank. arrythmia. University of Acarbose and older adults with Postprandial hypotension, British Columbia postprandial hypotension. geriatric medicine, syncope, alpha-glucosidase inhibitor, falls in older adults. University of Active streets, active people Built environment, physical British Columbia -junior: an integrated community activity, children health, youth partnership to enhance physical health, active transport. activity and active transport to school in children and youth. 107, ,839 I,II 77,613 77,613 II 67, ,294 I,II 51, ,905 II,IV Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 45

52 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Murphy, Tim Pryzdial, Ed Rodrigues, Brian B. Rossi, Fabio M.V. Veenstra, Gerry Zehr, Paul Research Institution Project Keywords Term $ Cumulative Theme(s) $ to University of British Columbia Using light to probe and modify neuronal excitability and blood flow of the evolving ischemic penumbra. Stroke, penumbra, imaging, 2-photon, optogenetics. Canadian Blood Auxiliary cofactors in fibrinolysis. Fibrinolysis, thrombosis, Services factor X, tissue plasminogen activator, hemostasis. University of Control of cardiac metabolism Cardiac metabolism, British Columbia following diabetes by FoxO. diabetes, insulin resistance, lipotoxicity, cardiomyopathy. University of Characterization and therapeutic Obesity, metabolic British Columbia potential of adipogenic syndrome, stem/progenitor progenitors. cells. University of Using combined waves of the Intersectionality theory, British Columbia Canadian Community Health Canadian Community Health Survey to investigate distinct Survey, race, class, gender. and intersecting effects of race, gender, class and sexual orientation on cardiovascular health outcomes. University of Tapping into interlimb neuronal Neurophysiology, stroke Victoria linkages to enhance locomotor recovery, walking, ability after stroke. translational research. Alberta/Northwest Territories/Nunavut Principal Investigator and Co-Investigator(s) Ahmed, Sofia B.; Exner, Derek; Hemmelgarn, Brenda Barber, Philip A.; Demchuk, Andrew; Frayne, Richard; Goyal, Mayank; Lee, Ting-Yim; Menon, Bijoy; Tuor, Ursula Beaulieu, Christian; Butcher, Kenneth; Emery, Derek Braam, Geert Branko; Cupples, William A. Research Institution Project Keywords Term $ Cumulative Theme(s) $ to University of Vitamin D supplementation Calgary and cardiac autonomic tone in hemodialysis patients: a blinded, randomized placebo-controlled trial. University of Recanalization following Calgary Endovascular treatment and imaging of PErfusion, Regional infarction and atrophy to Understand Stroke Evolution (REPERFUSE). University of Advances in high field MRI of Alberta stroke. University of Renal venous pressure, renal Alberta function and experimental heart failure. Cardiac autonomic tone, vitamin D, hemodialysis, kidney, sudden cardiac death. Stroke, reperfusion injury, thrombectomy, MRI, Magnetic resonance imaging, stroke, transient ischemic attack, diffusion weighted imaging, perfusion weighted imaging. Renal venous pressure, renal hemodynamics, glomerular filtration, experimental heart failure. 81, ,228 I 107, ,750 I,II , ,319 I , ,197 I 23,275 43,700 IV 87, ,746 I,II 30,080 30,080 II 68,835 68,835 I,II 65, ,773 II 113, ,667 I 46

53 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Butcher, Ken; Asdaghi, Negar; Aviv, Richard; Beaulieu, Christian; Buck, Brian; Casaubon, Leanne; Coutts, Shelagh; Demchuk, Andrew; Dowlatshahi, Dariush; Gladstone, David; Hill, Michael; Jeerakathil, Thomas; Jurasz, Paul; Lanthier, Sylvain; Qureshi, Adnan; Saposnik, Gustavo; Shuaib, Ashfaq; Wilman, Alan Clanachan, Alexander S.; Zaugg, Michael Darsaut, Tim E. Dukelow, Sean; Scott, Stephen; Hill, Michael; Demchuk, Andrew Ezekowitz, Justin; Armstrong, Paul; Kaul, Padma; Welsh, Robert Febbraio, Maria Gillis, Anne M. Gui, Yu Jahroudi, Nadia Research Institution Project Keywords Term $ Cumulative Theme(s) $ to University of Alberta The intracerebral hemorrhage acutely decreasing arterial pressure trial II. University of Novel therapy against Alberta ischemia-reperfusion injury in the infarct-remodeled heart. University of Aneurysm treatment with flow Alberta diversion: Potential factors predicting aneurysm and branch occlusion. University of A randomized controlled trial of Calgary early robotic rehabilitation of the upper limb following stroke. University of PROACT-4. Alberta University of Periodontal disease mechanisms Alberta in atherosclerosis. University of Carvedilol for prevention of Calgary paroxysmal atrial fibrillation. University of Regulation of vascular smooth Calgary muscle function by the novel G protein-coupled. estrogen receptor: Potential role in cardiovascular protection. University of Mechanism of endothelial specific Alberta gene regulation. Stroke, intracerebral hemorrhage, hypertension, ischemia, MRI. Cardiac ischemia-reperfusion, cardioprotection, fat emulsions, energy substrate metabolism. Intracranial aneurysms, stents, flow diversion, animal models. Stroke, rehabilitation, robotics, neuroscience. Acute coronary syndrome, ambulance, troponin. CD36, Toll like receptors, atherosclerosis, periodontal disease. Atrial fibrillation, randomized clinical trial, b-blockers, carvedilol, metoprolol. Estrogen receptor, GPR30, vascular smooth muscle. Endothelial cells, von willebrand factor, transcription, transgenic mice, promoter. 73,750 73,750 I,II 90, ,844 I , ,000 I 104, ,206 II 99,291 99,291 II 84,220 84,220 I,II , ,000 II , ,000 I , ,000 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 47

54 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Kassiri, Zamaneh Kassiri, Zamaneh King-Shier, Kathryn M.; Mather, Charles; Khan, Nadia A.; Quan, Hude; Chong, Elaine Kirton, Adam; Hill, Michael D.; Goodyear, Bradley G.; Beaulieu, Christian; Dewey, Deborah; Chen, Robert; Dukelow, Sean; Andersen, John Kubes, Paul Lopaschuk, Gary D. MacDonald, Justin A. Mackie, Andrew S; Magill-Evans, Joyce E.; Nicholas, David B.; Sananes, Renee; Anthony, Samantha J.; McCrindle, Brian W.; Yasui, Yutaka; Rempel, Gwendolyn R.; Kovacs, Adrienne H.; Oechslin, Erwin N.; Kaufman, Miriam E. Research Institution Project Keywords Term $ Cumulative Theme(s) $ to University of Paradoxical role of matrix Alberta metaloproteinase-2 in aortic aneurysm. University of Role of TNF-alpha Converting Alberta Enzyme (TACE) in Heart Disease. University of Developing and examining a Calgary descriptive decision model: Ethno-cultural and gender differences in medication adherence following acute coronary syndrome presentation. University of Enhancing developmental motor Calgary plasticity in perinatal stroke with transcranial direct current stimulation. University of Role of NKT cells in altered Calgary immune status following cerebral ischemia-reperfusion injury. University of The metabolic basis of heart Alberta failure in obesity and diabetes. University of Zipper-interacting protein Calgary kinase: Structure and functional implications in vascular smooth muscle contraction. University of The CHAPTER Study: Congenital Alberta Heart Adolescents Participating in Transition Evaluation Research. Aortic aneurysm, vascular extracellular matrix, smooth mucle cell, TGFbeta pathway. Heart disease, myocardial infarction, pressure overload, TNF-alpha-converting enzyme (TACE), cardiac remodeling. Ethno-cultural, medication adherence, gender, qualitative, survey. Perinatal stroke, cerebral palsy, neuroplasticity, non-invasive brain stimulation, neurophysiology. NKT cells, stroke, infection, immunosuppression. Fatty acid oxidation, diabetes, heart failure, obesity, energy metabolism. Smooth muscle, signal transduction, vascular contractility, chemical genomics, protein biochemistry. Congenital heart disease, pediatric, adult, continuity of care, transition. 95,842 95,842 I 85,942 85,942 I , ,000 II,III,IV , ,000 I,II , ,000 I , ,000 I , ,000 I , ,942 II,III,IV 48

55 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Michelakis, Evangelos D. O'Brien, Edward R.M. Ohinmaa, Arto E.; Klarenbach, Scott W.; Kaul, Padma; Jacobs, Philip; Jeerakathil, Thomas; Ruseski, Jane; Friesen, Dan Plane, Frances Poulin, Marc; Anderson, Todd; Hanly, Patrick Proctor, Spencer D. Seubert, John M. Smith, Eric E.; Frayne, Richard; Goodyear, Brad; Haffenden, Angela Smith, Eric E.; Lear, Scott; Yusuf, Salim; Teo, Koon; Poirier, Paul; O Donnell, Martin; Dagenais, Gilles; Pare, Guillaume; Islam, Shofiqul; Hart, Robert; Benavente, Oscar; Stotts, Grant Research Institution Project Keywords Term $ Cumulative Theme(s) $ to University of Alberta A chamber-specific mitochondriaangiogenesis axis underlies right ventricular failure in pulmonary hypertension. Angiogenesis, right ventricle, heart failure, pulmonary hypertension, metabolism. University of Heat shock protein 27: Atherosclerosis, macrophage, Calgary extracellular release and signaling. inflammation, heat shock protein. University of Canadian health outcomes, Performance, cost, Alberta performance and efficiency outcomes, health economics, (CanHOPE) - project for analysis productivity. of AMI and stroke care data for policy making. University of Endothelial potassium channels Endothelial dysfunction, Alberta as targets for novel vascular drugs. diabetes, potassium channel, nitric oxide. University of Role of intermittent hypoxia in the Obstructive sleep apnea, Calgary pathogenesis of obstructive sleep intermittent hypoxia, apnea. cerebrovascular regulation, stroke, endothelial dysfunction. University of Mechanisms that promote Human atherosclerosis, Alberta remnant lipoprotein retention remnant cholesterol, arterial in arterial tissue during retention, apolipoprotein B, atherogenesis and insulin proteoglycans. resistance. University of Role of eicosanoids in regulating Mitochondria, aging, Alberta mitochondrial quality in the epoxyeicosatrienoic acid, aged heart. ischemia-reperfusion injury, autophagy. University of Cognition and vascular function Cerebral amyloid angiopathy, Calgary in cerebral amyloid angiopathy. vascular dementia, stroke. University of Relationship between covert Stroke, silent stroke, Calgary brain ischemia and cognitive and cognitive impairment, physical decline in middle-aged vascular dementia, Canadians. leukoaraiosis. 74, ,244 I 91, ,986 I,II 36, ,450 II,III,IV 85, ,043 I 93, ,444 I,II,III,IV 93,100 93,100 I,II 90, ,041 I , ,000 II 52, ,292 II,IV Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 49

56 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Stickland, Michael K.; Haykowsky, Mark; Ezekowitz, Justin; McMurtry, Michael; Edgell, Heather Sykes, Brian D.; Hwang, Peter; West, Frederick ter Keurs, Hendrik E.D.J. Tse, Amy West, Lori J. White, James A.; Tang, Anthony; Birnie, David; Larose, Eric; Dick, Alexander; Bryant, Dianne; Thibault, Bernard; Phillipon, Francois; Friedrich, Matthias; Yee, Raymond; Gula, Lorne Young, Howard Zaugg, Michael Research Institution Project Keywords Term $ Cumulative Theme(s) $ to University of Alberta Mechanisms and functional significance of enhanced carotid chemosensitivity in health and heart failure. Heart failure, carotid chemosensitivity, sympathetic nerve activity, ultrasound. University of Development of calcium Heart failure, calcium Alberta sensitizers that target troponin. sensitizers, drug development, ischemic heart disease, protein structure. University of Calcium & cardiac sarcomere Cardiac muscle, excitation Calgary mechanics. contraction, sarcomere mechanics, high speed confocal microscopy of Ca. University of Regulation of chemotransduction Quantal release, exocytosis, Alberta in carotid bodies. transmitter release, cholesterol, calcium. University of ABO-incompatible heart ABO blood group, heart Alberta transplantation in a murine transplantation, tolerance, model: investigation of rejection, B cell, neonate. accommodation and tolerance. University of Aneurysm treatment with flow Cardiac resynchronization Alberta diversion: potential factors therapy, lead guidance, predicting aneurysm and branch magnetic resonance imaging, occlusion. randomized controlled trial. University of Molecular insights into SERCA Phospholamban, Alberta dysregulation in dilated sarcoplasmic reticulum, cardiomyopathy. calcium transport, SERCA, dilated cardiomyopathy. University of Regulation of energy metabolism Diabetes mellitus, Alberta in stressed type II diabetic hearts: cardiomyopathy, ischemia/ mechanisms and signaling reperfusion. pathways. 52, ,400 I,II 63,000 63,000 I , ,000 I , ,000 I , ,000 I , ,274 II , ,000 I , ,000 I 50

57 Heart and Stroke Foundation Research Report Saskatchewan Principal Investigator and Co-Investigator(s) Chilibeck, Philip D.; Zello, Gordon Kryworuchko, Jennifer; Fowler, Robert; Gallagher, Romayne Sawicki, Grzegorz (Greg) Research Institution Project Keywords Term $ Cumulative Theme(s) $ to University of Saskatchewan Effect of exercise and glycemic index of carbohydrate feeding on postprandial lipid metabolism. Exercise, glycemic index, triglycerides, glucose, atherosclerosis. University of Evaluation of a novel Shared decision making, Saskatchewan cardiopulmonary resuscitation cardiopulmonary (CPR) video decision aid to resuscitation, patient promote shared decision-making decision aid, serious illness, with seriously ill patients and their care planning. families. University of Protection of heart mechanical Oxidative stress, Saskatchewan function by inhibition of oxidative cardiovascular, myosin stress dependent modifications light chain, matrix of contractile proteins and their metalloproteinase, posttranslational degradation by MMP-2. modifications. Manitoba Principal Investigator and Co-Investigator(s) Dakshinamurti, Shyamala Dixon, Ian M C; Czubryt, Micheal; Wigle, Jeffery Hatch, Grant M. Kirshenbaum, Lorrie A. McGavock, Jonathan M.; Dolinsky, Vernon W.; Wicklow, Brandy; Sellers, Elizabeth; Dean, Heather; Dart, Allison Ravandi, Amir Research Institution Project Keywords Term $ Cumulative Theme(s) $ to University of Manitoba Effect of neonatal hypoxia on pulmonary artery and right ventricle adenylyl cyclase. University of Ski and scleraxis form a negative Manitoba feedback loop in regulation of cardiac myofibroblast function. University of Regulation of cardiolipin Manitoba biosynthesis in the heart. University of Mechanisms of P53 mediated cell Manitoba death in the heart. University of Developmental origins of diabetic Manitoba cardiomyopathy. St. Boniface G.H. Role of oxidized phospholipids Research Centre in myocardial ischemia and reperfusion injury. Neonatal hypoxia, adenylyl cyclase, G alpha s, pulmonary hypertension, PPHN. Heart failure, myocardial infarction, cardiac fibrosis, gene expression, myofibroblasts. Heart failure, phospholipid, gene therapy, cardiolipin, pulmonary hypertension. P53, apoptisis, heart failure, ventricular myocytes, cell culture. Developmental origins, diabetic cardiomyopathy, lipotoxicity, AMPK, exercise. Lipidomics, oxidized lipids, oxidative stress, reperfusion injury, apoptosis , ,000 I,II 15,539 60,682 III , ,000 I 90, ,586 I 101, ,856 I 89,350 89,350 I 63,075 63,075 I 68, ,427 I,II 68,791 68,791 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 51

58 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Stetefeld, Jörg Research Institution Project Keywords Term $ Cumulative Theme(s) $ to University of Manitoba Rhodocetin- A snake venom lectin with dual platelet surface receptor binding profiles. Snake venom lectin rhodocetin, a2b1 integrin and GPIb surface receptor, platelet activation and aggregation, structural biology and integrated approach, structure-based drug design. Ontario Principal Investigator and Co-Investigator(s) Adeli, Khosrow Advani, Andrew; Connelly, Kim Research Institution Project Keywords Term $ Cumulative Theme(s) $ to Hospital for Sick Children Mechanisms of hepatic VLDL overproduction and steatosis in insulin resistant states. Insulin resistance, liver, VLDL, apolipoprotein B, steatosis. St. Michael's HDAC6 in cardiorenal disease. Cardiorenal disease, diastolic Hospital dysfunction, chronic kidney disease, histone, acetylation. 92,500 92,500 I , ,437 I 96,729 96,729 I Andrew, R. David Queen's University Higher brain susceptibility and Neurophysiology, 76,283 76,283 I,II lower brain resiliency to ischemic injury. neurons, ischemia, stroke, neuroprotection. Austin, Richard C. St. Joseph's Contribution of cell surface Cell surface GRP78, 102, ,308 I Hospital GRP78 to the development and progression of atherothrombosis. tissue factor, thrombin generation, atherosclerosis, thromboembolic disease. Bai, Donglin University of Connexin43 and connexin40 Cardiac arrhythmias, gap 92, ,382 I,II Western Ontario mutants and cardiac arrhythmias. junction, connexin, atrial fibrillation, patch clamp. Beanlands, Rob S.B.; University of Atherosclerotic plaque imaging Atherosclerosis, PET/CT 105, ,683 I,II,III Spence, John; DaSilva, Jean; Ruddy, Terrence; de Kemp, Robert; Prato, Frank; Cocker, Myra; Lum, Cheemun; Stotts, Grant; Hammond, Robert Ottawa Heart Institute using NaF and FDG imaging: validation and evaluation of disease progression. A Canadian atherosclerosis imaging network (CAIN)-II histopathology validation study. imaging, [18F]-sodium fluoride, calcification, [18F]-fluorodeoxyglucose. Bendeck, Michelle P. University of Toronto Cadherins and the regulation of smooth muscle cell function. Atherosclerosis, restenosis, cadherin, cell migration, therapeutics , ,258 I,II 52

59 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Birnie, David H.; Essebag, Vidal; Ayala Paredes, Felix; Coutu, Benoit; Coyle, Doug; Eikelboom, John; Healey, Jeff; Nery, Pablo; Philippon, Francois; Sapp, John; Verma, Atul; Wells, George Bolz, Steffen-Sebastian Brooks, Steven C.; Mamdani, Muhammad; Morrison, Laurie; Dainty, Katie; Scales, Damon; Howes, Daniel; Craig, Alan; Chan, Timothy; Tu, Tony; Lebovic, Gerald; Kapoor, Vimal Scott; Feldman, Michael Caldarone, Christopher A.; Guerguerian, Anne-Marie; Dennis, Maureen; Sananes, Renee; McCrindle, Brian; Van Arsdell, Glen; Holtby, Helen; Grosse-Wortmann, Lars; Laughlin, Suzanne; Chaturvedi, Rajiv; Schwartz, Steven Cepinskas, Gediminas (Gedas); Fraser, Douglas D. Chakrabarti, Subrata Research Institution Project Keywords Term $ Cumulative Theme(s) $ to Anti-coagulation, peri-operative, arrhythmia device, novel anti-coagulants, stroke. Resistance arteries, cystic fibrosis transmembrane regulator (CFTR), vascular smooth muscle, sphingosine- 1-phosphate, tumour necrosis factor. Cardiac arrest, bystander cardiopulmonary resuscitation, automated external defibrillators, information technology, smartphones. Hypoplastic left heart syndrome, surgical trial, neuropsychological and quality of life outcomes, systemic oxygen consumption and delivery, neuromonitoring. Inflammation/sepsis, cerebrovascular endothelium, carbon monoxide, cell signaling, leukocytes. Diabetes, endothelial mesenchymal transition, microrna, cardiac fibrosis. 58,500 58,500 II,III 118, ,213 I , ,481 II,III , ,234 I,II,III,IV University of BRUISE CONTROL-2: A Ottawa Heart randomized controlled trial Institute to compare Continued versus Interrupted Dabigatran at the time of device surgery, in patients at high risk of stroke. University of Correcting CFTR dysfunction: Toronto a new therapeutic strategy for normalizing microvascular reactivity in heart failure. Queen's University A novel smartphone application to increase bystander cardiopulmonary resuscitation and automated external defibrillator use on victims of out-of-hospital cardiac arrest. Hospital for Sick A randomized controlled trial Children of hybrid and norwood surgical strategies for single ventricle congenital heart disease. Lawson Health Carbon monoxide(co)- Research Institute dependent modulation of septic responses in human cerebrovascular endothelial cells. University of Vasoactive and cardioactive Western Ontario factors in diabetic heart disease , ,433 I 96, ,230 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 53

60 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Chauhan, Vijay S.; Krishnan, Sridhar Chen, Hsiao-Huei; Stewart, Alexandre Coles, John G.; Maynes, Jason Copeland, John W. Research Institution Project Keywords Term $ Cumulative Theme(s) $ to University Health Network Characterizing focal electrical sources and substrate in human atrial fibrillation. Atrial fibrillation, electrogram analysis, scar, catheter ablation, humans. Ottawa Hospital Modulation of innate immunity to Innate immunity, stroke, Research Institute reduce stroke injury and improve apotosis, translational recovery. regulation, knockout mice. Hospital for Sick Rescue of disrupted Gene therapy, integrin Children mechanotransduction as a new linked kinase, dilated therapeutic strategy in human cardiomyopathy, mouse dilated cardiomyopathy. models, SERCA2A. University of Shear stress induced activation of Shear stress, endothelium, Ottawa cytoskeletal signaling pathways. cytoskeleton, signal transduction, gene regulation. 78,942 78,942 I,II 103, ,499 I 84,357 84,357 I 108, ,680 I Crowther, Mark A.; Blostein, Mark; Ginsberg, Jeffrey; Kahn, Susan; Schulman, Sam; Carrier, Marc; Wu, Cynthia McMaster University Rivaroxaban for the secondary prevention of thromboembolism in patients with the antiphospholipid antibody syndrome. Stroke, myocardial infarction, venous thromboembolism, cohort study, rivaroxaban. 52,263 94,432 II Cummins, Carolyn University of Toronto EPCs in atherosclerosis: role of intracellular cholesterol and LXR signaling. Endothelial progenitor cell, liver x receptor, cholesterol, atherosclerosis, LDLR. 77, ,109 I Cunningham, Charles H.; Connelly, Kim; Wright, Graham Sunnybrook Health Sciences Centre Metabolic imaging of the hypertrophic heart. Heart failure, hypertrophy, metabolism, imaging, hyperpolarized MRI. 82,625 82,625 I,II Danckert, James A.; Ferber, Susanne; Black, Sandra; Roy, Eric University of Waterloo Working memory in spatial neglect: developing a novel theory and rehabilitation program. Spatial neglect, spatial working memory, rehabilitation. 62,957 62,957 I,II Davis, Darryl R. University of Ottawa Heart Institute Strategies to reverse the effect of hyperglycemia on cardiac stem cells. Cardiac stem cells, heart failure, diabetes. 94,354 94,354 I Douketis, James D.D.; Bell, Benjamin; Blostein, Mark; Carrier, Marc; Gross, Peter; Kassis, Jeannine; Lee, Anges; MacKay, Elizabeth; Schulman, Sam; Shivakumar, Sudeep; Solymoss, Susan; Spencer, Frederick; Syed, Summer McMaster University Perioperative new oral anticoagulant study. New oral anticoagulants, perioperative, laboratory testing. 68,150 68,150 II 54

61 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Dowlatshahi, Dariush; Chakraborty, Santanu; Aviv, Richard; Demchuk, Andrew; Hogan, Matthew; Momoli, Franco; Stotts, Grant Drangova, Maria; Gillies, Elizabeth; Pickering, Geoff Drucker, Daniel J. Dumont, Daniel J. Finestone, Hillel M.; Sveistrup, Heidi; Bilodeau, Martin; Fergusson, Dean; Levac, Danielle Giacca, Adria Goldfield, Gary S.; Barrowman, Nick; Walker, Mark; Doucet, Eric; Tremblay, Mark; Adamo, Kristi; Fried, Peter Graham, Simon J.; Saposnik, Gustavo; Boe, Shaun; Staines, Richard William; Schweizer, Tom; Black, Sandra Gramolini, Anthony O. Grant, David; Levy, Gary; Ross, Heather Research Institution Project Keywords Term $ Cumulative Theme(s) $ to Ottawa Hospital Research Institute Predicting intracerebral hemorrhage expansion using the dynamic CT-angiography spot sign. University of Dual energy micro-ct for 3D Western Ontario angiography and cardiovascular histology. Samuel Lunenfeld Cardiovascular biology of Research Institute dipeptidyl peptidase-4. Sunnybrook Examination of the novel Health Sciences angiopoietin peptide mimetic Centre vasculotide as a treatment for atherosclerosis and ischemia. Elisabeth Bruyère Does virtual reality exercise Hospital improve sitting balance ability and function after stroke? University of Resveratrol and nitric oxide Toronto delivery as strategies to bypass vascular insulin resistance. Children's Effects of prenatal exposure Hospital of to cigarettes on adiposity and Eastern Ontario metabolism in young children. Sunnybrook FMRI neurofeedback applied to Health Sciences motor imagery in stroke. Centre University of Phospholamban mutations, Toronto sarcoplasmic reticulum calcium defects and cardiomyopathy. Toronto General Fgl2/FGL2 and heart Hospital allotransplantation. Cerebral hemorrhage, stroke, diagnosis, critical care. Micro-CT, atherosclerosis, dual energy, myocardial infarction. Diabetes, gut peptides, cardiomyocytes. Tie2, artherosclerosis, ischemia, limb disease, myocardial infarction. Stroke, rehabilitation, virtual reality, balance, exercise. Restenosis, resveratrol, nitric oxide, insulin resistance. Childhood obesity, smoking, pregnancy, metabolism. Functional MRI, stroke recovery, neurofeedback, motor imagery, physical rehabilitation. Excitation contraction coupling, calcium, cardiomyocyte. Transplantation, tolerance, macrophage, T regulatory cells, receptors. 58,282 58,282 I,II 102, ,252 I 82,080 82,080 I 79,930 79,930 I 94,478 94,478 II,III 129, ,699 I,II 96, ,293 IV 79, ,694 I 88,250 88,250 I,II 99, ,858 I,II Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 55

62 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Gros, Robert Hamilton, Jill K.; Comelli, Elena; Hanley, Anthony; Parkinson, John; Retnakaran, Ravi; Zinman, Bernard Hegele, Robert A. Hess, David A.; Postovit, Lynne-Marie Huff, Murray W. Ikura, Mitsuhiko Janssen, Ian M.; McIsaac, Michael Jerath, Angela; Wijeysundera, Duminda; Pang, Sandy; Beattie, William; Yau, Terrence; Pawliszyn, Janusz; Wasowicz, Marcin Johri, Amer M.; Heyland, Darren; Spence, John Kearon, Clive; Liaw, Patricia; Julian, James A.; Weitz, Jeffrey I. Research Institution Project Keywords Term $ Cumulative Theme(s) $ to University of Western Ontario The protective role of the cholinergic system in the heart. Genetically modified mice, cholinergic tone, cardiac dysfunction, hemodynamic measurements, ECG telemetry. Hospital for Sick Cardiometabolic risk, obesity and Cardiometabolic risk, Children the microbiome: development obesity, intestinal microbiota, over the first two years of life in gestational diabetes, child. children exposed to gestational diabetes in utero. Robarts Research Phenomics of monogenic Atherosclerosis, genomics, Institute cardiometabolic syndrome. insulin resistance, phenomics, cardiometabolic risk. Robarts Research Progenitor cell regulation of the Umbilical cord blood Institute vascular regenerative niche. progenitor cells, aldehyde dehydrogenase activity, angiogenesis, peripheral vascular disease, ischemia. University of Regulation of dyslipidemia and Dyslipidemia, flavonoids, Western Ontario insulin resistance by flavonoids: insulin signalling, mouse Relationship to atherosclerosis. model of insulin resistance, atherosclerosis. University Health Structural basis for STIM and Calcium signaling, signal Network Orai function in the heart and transduction, structural vasculature. biology, ion channel, protein structure. Queen's University The active play study. Physical activity, cardiovascular risk factors, children, determinants of health. Toronto General Hospital Plasma concentration and pharmacokinetics of tranexamic acid in patients with renal impairment undergoing cardiopulmonary bypass surgery. Tranexamic acid, chronic renal dysfunction, pharmacokinetics, cardiac surgery. Queen's University Effect of carnitine Atherosclerosis, metabolic supplementation on progression syndrome, three-dimensional of carotid plaque in the metabolic carotid ultrasound, plaque, syndrome (ECoM Study). obesity. McMaster Biochemical mechanisms of Protein C, venous University unprovoked VTE. thrombosis, inflammation, pathophysiology, biomarkers. 77, ,454 I 76,506 76,506 I,II,IV , ,755 I,II 102, ,989 I 90,792 90,792 I 91, ,010 I 91,615 91,615 IV 44,735 90,658 I,II,III,IV 104, ,383 I,II,III,IV , ,153 I,II 56

63 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Keeley, Fred W.; Parkinson, John Ko, Dennis T.; Jackevicius, Cynthia A.; Austin, Peter; Stukel, Therese; Tu, Jack Ko, Dennis; Tu, Jack V.; Austin, Peter C.; Peterson, Mark David; Alter, David A.; Cantor, Warren J.; Stukel, Therese A.; Strauss, Bradley H; Fremes, Stephen E.; Ruel, Marc; Natarajan, Madhu K; Cheema, Asim; Wijeysundera, Harindra C; Chu, Michael W.A. Koschinsky, Marlys L.; Boffa, Michael Kuebler, Wolfgang M. Lagace, Thomas Research Institution Project Keywords Term $ Cumulative Theme(s) $ to Hospital for Sick Effects of sequence Children polymorphisms in human tropoelastin on the assembly and mechanical properties of the elastic matrix. Implications for susceptibility to later onset vascular disease. Institute for Comparative effectiveness of Clinical Evaluative cardiac drugs post-myocardial Sciences infarction. Institute for Improving the assessment and Clinical Evaluative treatment of severe aortic stenosis Sciences by evaluating care gaps and advancing risk predictions. University of Role of oxidized phospholipids Windsor in the pathogenicity of lipoprotein(a). St. Michael's The mast cell - B cell axis in Hospital lung vascular remodelling and pulmonary hypertension. University of Regulation of the PCSK9 binding Ottawa Heart interaction with LDL receptor. Institute Sequence polymorphism, tropoelastin, elastic matrix, mutation, vascular disease. Acute myocardial infarction, comparative effectiveness evaluation, anti-platelet therapy, lipid lowering medication, generic medication. Aortic stenosis, health services research, risk prediction model, appropriateness, aortic valve surgery. Lipoprotein(a), apolipoprotein(a), atherosclerosis, oxidized phospholipids. Pulmonary hypertension, vascular remodelling, mast cells, B cells, endothelial cells. Low-density lipoprotein receptor, PCSK9, low-density lipoprotein cholesterol, protein-protein interaction, plasma clearance. 86, ,446 I 57,465 57,465 II,III , ,058 II,III 7,607 15,683 I 99, ,886 I , ,781 I,II Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 57

64 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Le Gal, Grégoire; Anderson, David; Huisman, Menno; Kahn, Susan; Kovacs, Michael; Ramsay, Timothy; Rodger, Marc; Tan, Melanie; Wells, Philip Lee, Douglas S.; Stukel, Therese; Ko, Dennis; Ross, Heather; Austin, Peter; Tu, Jack; Newton, Gary; Farkouh, Michael Li, Ren-Ke; Weisel, Richard D. Research Institution Project Keywords Term $ Cumulative Theme(s) $ to Ottawa Hospital Research Institute Clinical predictors for venous thromboembolism in patients with a history of thrombosis. Deep vein thrombosis, pulmonary embolism, anticoagulants, recurrence, clinical decision rule. Toronto General Early phase interventions for acute Heart failure, coronary heart Hospital Research ischemic heart failure. disease, outcomes, health Institute services research, quality of care. University Health Feasibility of a conductive Myocardial infarction, Network polymer biomaterial to cardiac conduction, resynchronize the infarcted heart. conductive biomaterial, tissue engineering, cardiac function. 80,804 80,804 II 161, ,103 II,III,IV 80,764 80,764 I Lillicrap, David P. Queen's University Quantitative and qualitative Blood, hemostasis, aging, , ,563 I,II age-related pathologies of von Willebrand factor. von Willebrand factor, thrombosis. Longmuir, Patricia E.; Children's LIFE and health for young children Physical activity, motor skill, 73, ,140 II Barrowman, Nicholas; Timmons, Brian; Tremblay, Mark; Dillenburg, Rejane; Adamo, Kristi; Lee, Suzie Hospital of Eastern Ontario with congenital heart defects (Learning, Inclusion, Friends and Emotional and physical Health). paediatric, congenital heart disease, accelerometry. Macdonald, Robert; St. Michael's TNF-alpha signaling in Subarachnoid hemorrhage, 57, ,214 I Bolz, Steffen-Sebastian; Ai, Jinglu Hospital subarachnoid hemorrhage. vasospasm, TNFalpha, microvessels, sphingosine kinase 1. Mackie, Andrew S.; Magill-Evans, Joyce E.; Nicholas, David B.; Sananes, Renee; Anthony, Samantha J.; McCrindle, Brian W.; Yasui, Yutaka; Rempel, Gwendolyn R.; Kovacs, Adrienne H.; Oechslin, Erwin N.; Kaufman, Miriam E. University of Alberta The CHAPTER Study: Congenital Heart Adolescents Participating in Transition Evaluation Research. Congenital heart disease, pediatric, adult, continuity of care, transition , ,173 II,III,IV 58

65 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) McNally, James D.; Fergusson, Dean; McIntyre, Lauralyn; Weiler, Hope; Menon, Kusum; Lawson, Margaret; Doherty, Dermot; Maharajh, Gyaandeo Mehta, Sanjay; Gill, Sean Meyre, David; Mente, Andrew; Anand, Sonia; Gerstein, Hertzel Mielniczuk, Lisa M.; Wells, George; Beanlands, Rob S.B.; DaSilva, Jean; dekemp, Robert; Davies, Ross; Haddad, Haissam; Dick, Alexander; Stewart, Duncan Min, Wei-Ping Monnier, Philippe P. Morshead, Cindi M.; Corbett, Dale R; Shoichet, Molly S. Nemer, Mona Nemer, Mona Park, David S. Research Institution Project Keywords Term $ Cumulative Theme(s) $ to Children's Prevention of post-operative Hospital of vitamin D deficiency in children Eastern Ontario with congenital heart disease: a dose evaluation trial. London Health Mechanisms of microvascular Sciences Centre endothelial cell apoptosis in sepsis. McMaster Contribution of the lipid sensor University GPR120 loss-of-function coding variant R270H to energy intake, obesity and type 2 diabetes in humans. University of Right ventricular substrate Ottawa Heart metabolism as a predictor of Institute right heart failure in patients with pulmonary arterial hypertension (RV-MET study). University of The role of mtor and Western Ontario TLR signaling networks on alloimmune modulation in heart transplantation. Toronto Western Modulation of the RGMa/ Hospital Neogenin pathway promotes cell survival and regeneration after stroke. University of Promoting self repair by Toronto endogenous stimulation and rehabilitation following stroke. University of Mechanisms of TBX5 action in Ottawa the heart. University of Transcription networks in cardiac Ottawa hypertrophy. University of The role of Pink1 in stroke. Ottawa Vitamin D, congenital heart disease, surgery, clinical trial, risk factors. Sepsis, endothelium, apoptosis, neutrophil, human. Lipid sensor, obesity, type 2 diabetes, genetics, ethnic diversity. Heart failure, pulmonary hypertension, cardiac metabolism, PET imaging. Heart transplantation, mtor, TLR, RNA interfrence, tolerance. Neuronal survival, axonal regeneration, stroke, membrane proteins. Neural stem cells, drug delivery system, cognition, endogenous stimulation. Holt-oram syndrome, transcription regulation, heart development, animal models of disease, TBX proteins. Cardiac hypertrophy, heart failure, gene regulation, transcription factors, vasoactive hormones. Stroke, neuronal death, mitochondria, AKT, oxidative stress. 68, ,279 I,II,III,IV 120, ,661 I 55, ,274 I 85, ,300 I,II 101, ,168 I 87, ,963 I , ,630 I 90,271 90,271 I 86,499 86,499 I 115, ,638 I,II Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 59

66 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Parker, Thomas G. Parkinson, John; Keeley, Fred Pausova, Zdenka; Bennett, Steffany; Gaudet, Daniel; Abrahamowicz, Michal Rand, Margaret L. Reid, Robert D.; Grace, Sherry L.; Blanchard, Chris; Chessex, Caroline; Harris, Jennifer; Kingsbury, Kori; Krahn, Murray; Manuel, Douglas; Mark, Amy; Mullen, Kerri-Anne; Pipe, Andrew Reid, Robert D.; Wells, George; Mielniczuk, Lisa; Chan, Kwan-Leung; Pipe, Andrew; Mark, Amy; Tulloch, Heather; Harris, Jennifer; Keast, Marja-Leena Roy, Eric A.; Black, Sandra E.; Graham, Simon; Hebert, Deborah; Park, Norman; Schweizer, Tom; Staines, Richard Research Institution Project Keywords Term $ Cumulative Theme(s) $ to St. Michael's Hospital S100A1 and A6 proteins in pulmonary vascular pathophysiology: intracellular, extracellular, and cell-lineage specific mechanisms of action. S100 proteins, pulmonary hypertension, cell signalling. Hospital for Sick Towards a systems level Elastic fibres, systems Children understanding of the elastic fibre biology, thoracic aortic and its role in cardiovascular aneurysm and dissection, disease. next generation sequencing, sequence polymorphisms. Hospital for Sick Visceral fat and hypertension: Lipidomics profiling, visceral Children sex-specific lipidomic biomarkers fat, hypertension, sex, across generations. adolescence-adulthood. Hospital for Sick The procoagulant surface of Platelets, thrombosis, Children activated platelets: Development procoagulant activity, and persistence in vitro and phosphatidylserine. in vivo. University of Ecologically optimizing exercise Physical activity, cardiac Ottawa Heart maintenance in men and women rehabilitation, maintenance/ Institute post-cardiac rehabilitation: a adherence, coronary artery randomized controlled trial disease. of efficacy with economics (ECO-PCR). University of Randomized trial of nordic walking Heart failure, cardiac Ottawa Heart vs. standard cardiac rehabilitation rehabilitation, functional Institute in patients with heart failure. capacity, quality of life, nordic walking. University of Neuropsychological profiles and Movement neuroscience, Waterloo neuroanatomic correlates of limb apraxia, neuropsychology, apraxia. motor control, cognitive deficits. 94,843 94,843 I 89, ,290 I,II,IV 90, ,262 I,IV 89,391 89,391 I 145, ,941 II,III,IV 98, ,551 II,III 75,175 75,175 I,II,III,IV 60

67 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Saposnik, Gustavo; Bayley, Mark T.; Dukelow, Sean; Laupacis, Andreas; Mamdani, Muhammad; McIlroy, William; Teasell, Robert; Thorpe, Kevin Schlichter, Lyanne Scholey, James W. Schweizer, Tom A.; Graham, Simon; Saposnik, Gustavo; Naglie, Gary; Hung, Yuwen; Macdonald, Loch Scott, Ian Shargall, Yaron; Douketis, James; Farrokhyar, Forough; Linkins, Lori-Ann; Miller, John; Finley, Christian; Schieman, Colin; Gelberg, Jacob; Boylan, Colm Skerjanc, Ilona S. Slack, Ruth S. Sorisky, Alexander Stanford, William L. Research Institution Project Keywords Term $ Cumulative Theme(s) $ to St Michael's Hospital Efficacy of Virtual Reality Exercises using Wii gaming technology in STroke Rehabilitation: A multicentre randomized clinical trial (EVREST multicentre). Stroke rehabilitation, virtual reality, motor function, ischemic stroke, clinical trial. University Health Microglia podosomes: signalling Microglia, neuroinflammation, Network structures for ECM degradation & cell migration, migration. ion channels, fluorescence microscopy. University of Adiponectin signaling pathways Adiponectin, diabetes, Toronto and diabetic kidney injury. angiotensin, camp, NADPH oxidase. St. Michael's Understanding post-stroke driving Driving, fmri, stroke, Hospital capacity: an fmri driving simulator cognitive function. study. Hospital for Sick Live analysis of CCM mechanism Intracranial hemorrhage, Children and progression in a zebrafish cerebral cavernous CCM3 model. malformation, vascular integrity, stroke, zebrafish. McMaster Extended out-of-hospital VTE Deep venous thrombosis, University prophylaxis against deep venous pulmonary embolism, lung thrombosis and pulmonary resection, prophylaxis, embolus in patients undergoing venous thromboembolism. major lung resection: a pilot study to evaluate the incidence of DVT and PE. University of The regulation and role of Nkx2.5 Cardiomyogenesis, stem Ottawa in cardiac muscle development cell differentiation, gene and disease. expression, signaling pathways. University of Regulation of Opa1 to maintain Stroke, cell death, Ottawa mitochondrial energy metabolism mitochondria. and survival after stroke. Ottawa Hospital Adipose progenitor cell Obesity, adipose progenitor, Research Institute responses to nutrient stress and macrophage, high glucose, macrophages. inflammation. Ottawa Hospital The role of aberrant Lamin A Atherosclerosis, vascular Research Institute splice isoforms in vascular smooth smooth muscle cells, aging, muscle aging and disease. induced pluripotent stem cells, lamin A. 64,628 64,628 II,III , ,975 I 96, ,800 I 56, ,770 I,II 91,000 91,000 I 68, ,361 II , ,564 I 90,705 90,705 I 99,405 99,405 I,II 75, ,540 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 61

68 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Stefanovic, Bojana; Carlen, Peter; Corbett, Dale; Sled, John; Stanisz, Greg Steinman, David A. Stiell, Ian G.; Wells, George; Birnie, David; Perry, Jeffrey; Brison, Robert; Borgundvaag, Bjug Storey, Kenneth B. Sun, Hong-Shuo Research Institution Project Keywords Term $ Cumulative Theme(s) $ to Sunnybrook Health Sciences Centre The role of neurovascular remodelling in stroke rehabilitation. Magnetic resonance imaging, two-photon fluorescence microscopy, biophysical modelling, neurovascular coupling, brain microcirculation. University of Hemodynamics of cerebral Cerebral aneurysm, Toronto aneurysms: back to basics. hemodynamics, rupture risk, hemodynamics, turbulence. Ottawa Hospital A randomized, controlled Atrial fibrillation, atrial flutter, Research Institute comparison of electrical versus cardioversion, randomized pharmacological cardioversion for trial, emergency department. emergency department patients with recent-onset atrial fibrillation and flutter (RAFF). Carleton Suspended animation: Primate hibernation, University hypometabolic hearts in a model regulation of of primate torpor. hypometabolism, signal transduction & metabolic regulation, anti-apoptosis, epigenetic & microrna control of gene expression. University of Cellular and molecular Stroke, diabetes, animal Toronto mechanisms of stroke in diabetes models, ion channels, and its potential therapeutic treatment. treatments. Sweeney, Gary York University Metabolic effects of adiponectin on the heart: mechanisms and functional consequences. Adiponectin, cardiac metabolism, cardiomyopathy, obesity, diabetes. Sweeney, Gary York University Regulation of cardiac structure Lipocalin-2, inflammation, and function by lipocalin-2. cardiac remodeling, metabolism, autophagy. Timmons, Brian W.; Cellucci, Tania; MacDonald, Maureen; Thabane, Lehana McMaster University Cardiovascular Health in children with a chronic inflammatory condition: role of Physical activity, fitness, and inflammation: The CHAMPION Study. Physical activity, fitness, risk factors, inflammatory disease, vascular function. Trigatti, Bernardo L. McMaster Molecular mechanisms by which Atherosclerosis, cytokine, University interleukin-15 contributes to the receptor, genetics, development of atherosclerosis. lipoprotein , ,519 I 107, ,611 I,II 77, ,429 II,III 69,775 69,775 I 92, ,050 I 102, ,630 I 85, ,028 I 122, ,863 I, II 77, ,818 I 62

69 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Tu, Karen; Morra, Dante J.; Thorpe, Kevin; Saposnik, Gustavo; Dorian, Paul; Jaakkimainen, Liisa; Gladstone, David; Meshkat, Nazanin; Ivers, Noah; Butt, Debra; Bhatia, Sacha; Leblanc, Kori; Valentinis, Alissia Tuana, Balwant S. Vaillancourt, Christian; Wells, George; Stiell, Ian; Calder, Lisa Vasconcelos, Sara S. Nunes Verma, Subodh Verma, Subodh; Anderson, Todd J. Weitz, Jeffrey I. Wells, James W. Research Institution Project Keywords Term $ Cumulative Theme(s) $ to Institute for Clinical Evaluative Sciences Improving stroke prevention for patients with atrial fibrillation in primary care. University of The role of E2F6 in dilated Ottawa cardiomyopathy. Ottawa Hospital Improving the cardiac arrest Research Institute diagnostic accuracy of emergency medical dispatchers. University Health Arterio-venous specification Network during adult neovascularization. St. Michael's Elucidating the role of BRCA1 as Hospital a target to improve endothelial function, promote angiogenesis and attenuate atherosclerosis. St. Michael's The role of autophagy in Hospital cardiovascular disease: a bench to bedside translational approach. McMaster Impact of gamma'-fibrinogen on University clot formation and clot lysis at sites of plaque rupture. University of Nature of the signalling complex Toronto between cardiac muscarinic receptors and G proteins. Knowledge translation, atrial fibrillation, cluster random trial, stroke, guideline adherence. Heart failure, dilated heart, hypertrophy, transcription, remodeling. Cardiac arrest, bystander CPR, dispatch-assisted CPR instructions. Neovascularization, vessel maturation, artery and vein specification, endothelium, diabetes. BRCA1, endothelial function, atherosclerosis, tissue specific knockout mouse. Integrative cardiovascular medicine, knockout mice, translational science, endothelial function, atherosclerosis. Coagulation, fibrinolysis, thrombolysis, plasminogen activators. G protein-coupled receptors, transmembrane signalling, oligomers and co-operativity, drug-receptor interactions, potein-protein interactions. 80, ,614 II,III 89,000 89,000 I , ,978 III 96,000 96,000 I 110, ,761 I 96, ,897 I,II 117, ,979 I 90,004 90,004 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 63

70 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Wijeysundera, Duminda N.; Cuthbertson, Brian; Thorpe, Kevin; Beattie, W. Scott; Mazer, C. David; Granton, John; Mamdani, Muhammad; Oh, Paul; Brull, Richard; Wijeysundera, Harindra; McCartney, Colin Wu, Lingyun (Lily); Wang, Rui Yan, Andrew T.; Wald, Ron; Connelly, Kim; Goldstein, Marc; Kiaii, Mercedeh; Kirpalani, Anish; Lebovic, Gerald; Leipsic, Jonathan; Leong-poi, Howard; Wright, Graham; Yuen, Darren Yang, Guangdong; Khaper, Neelam Zandstra, Peter W. Research Institution Project Keywords Term $ Cumulative Theme(s) $ to St. Michael's Hospital The METS study: an international multicentre prospective cohort study of cardiopulmonary exercise testing for improving preoperative risk stratification for major non-cardiac surgery. Preoperative risk stratification, cardiopulmonary exercise testing, functional capacity, perioperative cardiac complications, prognostic studies. Lakehead Regulation of aldolase B Methyglyoxal, fructose, University expression and scavenging aldolase B, ChREBP, methylglyoxal in vascular smooth FoxO1/3a. muscle cells. St. Michael's Impact of in-centre nocturnal End-stage renal disease, Hospital hemodialysis on cardiac dialysis, left ventricular remodeling in end-stage renal mass and function, cardiac disease: A long-term follow-up magnetic resonance imaging, study. biomarkers. Lakehead Functional relevance of Hydrogen sulfide, University cystathionine gamma-lyase/h2s cystathionine gamma-lyase, system in vascular smooth muscle smooth muscle cells, cell phenotypes: a novel target neointimal formation, cell for the prevention of neointimal differentiation and migration. hyperplasia. University of Accelerating the development Myocardial infarction, human Toronto of regenerative biologics for pluripotent stem cell derived myocardial infarction using cardiomyocytes, engineered functional human microtissues. cardiac micro-tissue model, cardiomyocyte survival and proliferation screening, targeted protein delivery. 48,000 96,000 II,III 137, ,192 I 56,607 56,607 I,II,III , ,000 I 91,500 91,500 I 64

71 Heart and Stroke Foundation Research Report Quebec Bonnet, Sébastien; Couture, Christian; Provencher, Steeve Institut universitaire de cardiologie et de pneumologie de Québec Role for DNA damage signalling in pulmonary arterial hypertension. Pulmonary arterial hypertension, integrative studies, gene therapy, animal model. Bousette, Nicolas Montreal Heart The protective role of perilipin-2 Diabetes, lipotoxicity, ER Institute in diabetic cardiomyopathy. stress, lipids, apoptosis. Cardinal, René; Hôpital du Acute modulation and chronic Autonomic nervous Pagé, Pierre; Sacré-Coeur de remodelling of intrinsic cardiac system, intrinsic cardiac Smith, Frank Montréal nervous system properties during neurons, atrial/ventricular myocardial ischemia, atrial tachyarrhythmias, myocardial tachyarrhythmias, and spinal cord ischemia, thoracic spinal cord stimulation. stimulation. Cerruti, Marta G.; McGill University A multidisciplinary approach to Vascular calcification, Murshed, Monzur; unravel the mystery of vascular elastin, matrix Gla protein, Mantovani, Diego calcification. spectroscopic analysis, molecular biology techniques. Chahine, Mohamed Université Laval Mécanismes moléculaires de Canaux sodiques, arythmie mutations du gène SCN5A cardiaque, syndrome de trouvées chez des patients atteints Brugada, sydrome du QT du syndrome de Brugada et le long, génétique. syndrome du QT long. Principal Investigator Research Institution Project Keywords Term $ Cumulative Theme(s) and Co-Investigator(s) $ to Agharazii, Mohsen Université Laval Determinants of progression of Kidney disease, arterial ,000 42,000 I,II human aortic stiffness in renal failure: role of advanced glycation end products, oxidative stress, endothelin-1 and inflammation. stiffness, advanced glycation end-products, oxidative stress, inflammation. Allen, Bruce Institut de MAP Kinase-Activated Protein Protein kinase, p38 MAP 73,251 73,251 I cardiologie de Montréal Kinases (MKs) mediate distinct detrimental effects of p38 MAP kinase activation in heart. kinase, hypertrophy, fibrosis, signal transduction. Blostein, Mark D. Lady Davis Institute for Medical Research Role of gas6 and inflammation in the pathophysiology of venous thromboembolism. Venous thrombosis, inflammation, gas6. 138, ,500 I 71,002 71,002 I,II 99,408 99,408 I ,000 60,000 I 86, ,523 I ,000 60,000 I,II Claing, Audrey Université de Montréal Regulation of G protein-coupled receptor function by ARF6. G protein-coupled receptor, small GTP binding protein, migration, contraction, molecular mechanism ,000 60,000 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 65

72 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Dasgupta, Kaberi; Ross, Nancy A.; Gauvin, Lise; Joseph, Lawrence; Bacon, Simon; Kestens, Yan; Daskalopoulou, Stella Daskalopoulou, Styliani Stella; Dasgupta, Kaberi; Walker, Mark; Rahme, Elham; Gagnon, Robert; Pilote, Louise; El-Messidi, Amira D'Avanzo, Nazzareno Di Cristo, Graziella; Carmant, Lionel Drolet, Benoit; Simard, Chantale; Dumaine, Robert Montreal General Hospital predictive Value of arterial stiffness in the development of pre-eclampsia (REVEAL). Pregnancy, pre-eclampsia, arterial stiffness, hypertension, angiogenic factors of pre-eclampsia. Université de Lipid regulation of purified Lipid regulation of ion Montréal eukaryotic potassium channels. channels, electrophysiology, biochemistry, ion channel, arrhythmias. Hôpital Sainte Effects of neonatal hypoxia on Hypoxia, neonate, Justine brain development. development, cognitive impairments, GABAergic circuits. Institut The modulating role of metabolic Electrophysiology universitaire de syndrome in drug-induced QT patch-clamp, metabolic cardiologie et de interval prolongation. syndrome, action potentials, pneumologie de ECGs, QT-prolonging drugs. Québec Université de Gender-related differences in the Sodium channel, Sherbrooke distribution of the cardiac sodium repolarization dispersion. current as a mechanism for specificity of cardiac arrhythmias. Research Institution Project Keywords Term $ Cumulative $ to Theme(s) McGill University Novel real-time measurement of Vascular disease, physical ,000 60,000 II,IV physical activity patterns in type activity, global positioning 2 diabetes and hypertension system (GPS) monitoring, through GPS monitoring and geographic information accelerometry. system (GIS) mapping, built environment ,000 42,000 II 82, ,400 I ,000 42,000 I ,000 42,000 I ,000 60,000 I,II,IV Genest, Jacques McGill University High density lipoprotein (HDL) High density lipoproteins, ,000 42,000 I,II function in acute coronary syndromes. acute coronary syndromes, cholesterol efflux, apolipoprotein AI, nitric oxide. Girouard, Hélène Université de Mechanisms underlying Neurovascular coupling, ,000 60,000 I Montréal neurovascular coupling dysfunction in hypertension. angiotensin II, astrocyte, calcium signaling, potassium channels. Hamel, Edith Montreal Neurological Institute Cerebrovascular disease and cognitive failure in Alzheimer's disease. Alzheimer disease, mouse models of Alzheimer disease, cerebrovascular reactivity and blood flow measures, memory deficit, amyloidosis ,000 60,000 I 66

73 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Hamel, Edith; Adamantidis, Antoine; Shmuel, Amir Jacques, Danielle Kriz, Jasna; Sato, Sachiko Leask, Richard; Cartier, Raymond; Wiseman, Paul; Therrien, Judith; Pressacco, Josephine; Mongrain, Rosaire; El-Hamamsy, Ismail Lesage, Frédéric; Tardif, Jean-Claude Lesur, Olivier; Lecomte, Roger; Dumaine, Robert; Lepage, Martin Levin, Mindy; Feldman, Anatol Marelli, Ariane J.; Pilote, Louise; Abrahamowicz, Michal; Therrien, Judith; Ionescu-Ittu, Raluca Mathieu, Patrick; Paquin, Jean-Francois; Marette, Andre; Pibarot, Philippe Mourad, Walid M. Nattel, Stanley Research Institution Project Keywords Term $ Cumulative Theme(s) $ to Montreal Neurological Institute The cellular basis of neurovascular coupling in the cerebral cortex. Neurovascular coupling, neuroimaging, cerebrovascular diseases, blood vessel alterations. Université de Regulation of secretion of cardiac Endocardial endothelium, Sherbrooke endocardial endothelial cells by neuropeptide Y, left and neuropeptide Y. right ventricles, endothelin-1, hypertrophy. Centre Hospitalier The role of galectin-3 in Immune response, microglia, Universitaire de post-ischemic immune responses. stroke, galectins, therapy. Québec McGill University Aneurysms of the ascending Ascending aortic aorta; Linking hemodynamics to aneurysm, bicuspid valve local tissue stiffness, structure and patients, hemodynamics, biochemistry. biomechanics, local tissue remodeling. École Functionalized nanoparticles Atherosclerosis, molecular polytechnique applied to photo-acoustic imaging, fluorescence, de Montréal molecular imaging of photoacoustic. atherosclerotic plaque. Centre hospitalier The neuropeptide apelin (APL) Sepsis, dysfonction universitaire de is cardioprotective on myocardique, hémodynamie/ Sherbrooke endotoxin-induced heart imagerie, apoptose/ dysfunction. inflammation, apéline. Jewish Corticospinal contribution to Hypertonicity, modulatory Rehabilitation spasticity and disordered motor system, upper limb, stroke, Hospital control. TMS. McGill University Analyzing and reducing health Congenital heart disease, inequalities in adults with health services research, congenital heart disease. population health, epidemiology. Institut de Inhibition of ectonucleotide Calcific aortic valve cardiologie de pyrophosphatase / disease, aortic stenosis, Québec phosphodiesterase-1 with a novel ectonucleotidase, quinazolin-derived compound in pharmacological treatment, order to prevent the progression animal model. of aortic stenosis. Centre hospitalier Role of CD154 and its receptors in CD514, receptors, integrins, de l'université de atherothrombosis. atherosclerosis, inflammation. Montréal Montreal Heart Factors altering the interaction Cardiac arrhythmias, atrial Institute between antiarrhythmic drugs fibrillation, remodeling, and cardiac tissue: role of nuclear nuclear function, cell calcium. receptors and remodeling. 93,000 93,000 I 41,039 81,973 I 91, ,204 I ,000 60,000 I,II ,000 42,000 I,II ,000 42,000 I 59,397 59,397 I,II ,000 60,000 III,IV 94,925 94,925 I 79, ,119 I 100, ,886 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 67

74 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Nuyt, Anne Monique; deblois, Denis Ong, Huy; Marleau, Sylvie Rousseau, Eric; Morin, Caroline Rousseau, Guy Sébire, Guillaume Shrier, Alvin; Glass, Leon M. Sirois, Martin G. Thorin, Eric Turgeon, Jacques; Michaud, Véronique; Drolet, Benoit; Simard, Chantale Vohl, Marie-Claude; Perusse, Louis; Tchernof, Andre Research Institution Project Keywords Term $ Cumulative Theme(s) $ to Hôpital Sainte-Justine Transient neonatal oxygen exposure alters myocardial structure and function: Impact for adult cardiac diseases. Developmental programming of CV diseases, neonatal oxidative stress, cardiac development, cardiac diseases, aging. Université de Targeting CD36 and Atherosclerosis, CD36, Montréal proteoglycans in atherosclerosis. proteoglycan, active immunization, molecular imaging. Université de Mode d'action des Hypertension pulmonaire, Sherbrooke monoacylglycérides d'oméga biochimie des lipides, 3 et de leurs dérivés époxydés monoglyceride d'acide vasorelaxants dans la gras polyinsaturés microcirculation artérielle omega-3, eicosanoides, pulmonaire. CYP450 epoxygenases et hydroxylases. Hôpital du The importance of resolvins in Resolvin, omega-3, Sacré-Coeur de the cardioprotective effect of myocardial infarction, Montréal omega-3 fatty acids. inflammation, protection. Université de Rôle de la réponse inflammatoire Accident vasculaire Sherbrooke maternofoetale dans la cerebral, cytokines, physiopathologie des accidents inflammation gestationnelle, vasculaires cérébraux (AVC) vasculoprotection, périnatals. neuroprotection. McGill University Reentrant cardiac arrhythmia in Arrhythmias, dynamics, tissue culture. fluorescent imaging, ion channels, pharmacology. Montreal Heart Proinflammatory and angiogenic Angiopoietins, tie 2 receptor, Institute properties of the angiopoietins. neutrophils, cell signaling, inflammation. Montreal Heart Cerebral neurovascular function in Cerebral artery, ageing, Institute ageing and atherosclerosis. atherosclerosis, cerebral blood flow, cognition. Centre hospitalier The first characterization of Cytochromes P450, human de l'université de functional CYP450 activities cardiac myocytes, drug Montréal in human cardiac myocytes: metabolism, potassium modulation of cardiac K+ channel channels, QT-prolonging block due to the local metabolism drugs. of QT-prolonging drugs. Université Laval A study of genetic and epigenetic Metabolic syndrome, obesity, factors influencing obesity-related genetics, epigenetics, metabolic complications. adipose tissue ,000 42,000 I ,000 42,000 I ,000 60,000 I,II 89, ,886 I 62,849 62,849 I,II,IV ,000 60,000 I ,000 60,000 I ,000 42,000 I ,000 60,000 I,II 84,500 84,500 I,IV 68

75 Heart and Stroke Foundation Research Report Nova Scotia Principal Investigator and Co-Investigator(s) Parkash, Ratika; Wells, George; Krahn, Andrew; Exner, Derek; Tang, Anthony; Crystal, Eugene; Simpson, Chris; Thibault, Bernard; Essebag, Vidal; Philippon, François; Yee, Raymond; Stephenson, Elizabeth; Healey, Jeff; Nery, Pablo Pavlov, Evgeny Ridgway, Neale D. Rose, Robert A. Waisman, David M. Research Institution Project Keywords Term $ Cumulative Theme(s) $ to Nova Scotia Health Authority CHRS cardiac implantable electrical device surveillance system (CDSS) - a pilot study. Registry, surveillance, cardiac implantable electrical devices. Dalhousie Molecular basis of the Mitochondria, inorganic University pathological mitochondrial polyphosphate, membrane transport: roles of polyhydroxybutyrate, inorganic polyphosphate and permeability transition pore, polyhydroxybutyrate. calcium. Dalhousie Role of oxysterol binding proteinrelated Cholesterol, oxysterols, University protein 4 (ORP4) in sterol- lipid transport, cell survival, regulated cell proliferation. protein interaction. Dalhousie Effects of natriuretic peptides Arrhythmias, ion channels, University on atrial electrophysiology and action potential, natriuretic arrhythmogenesis. peptides, natriuretic peptide receptors. Dalhousie Defining the physiological S100A10, plasminogen, University function of S100A10 with the stroke, fibrinolysis, plasmin. S100A10 knockout mouse. Newfoundland and Labrador Principal Investigator and Co-Investigator(s) Gamble, John-Michael; Majumdar, Sumit R.; Midodzi, William; Twells, Laurie Research Institution Project Keywords Term $ Cumulative Theme(s) $ to Memorial Comparative cardiovascular University of effectiveness of the incretins. Newfoundland 63, ,201 II,III,IV 93, ,174 I , ,000 I , ,940 I 75,736 75,736 I Cardiovascular outcomes, comparative effectiveness research, diabetes, pharmacoepidemiology, health outcomes. 35, ,540 III,IV Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 69

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77 APPENDIX D RESEARCH CHAIRS AND PROFESSORSHIPS Photo: Dr. Georg Schmolzer (left) and Dr. Po-Yin Cheung (University of Alberta) are working together aiming to improve current new CPR practices to enhance infant survival. Dr. Georg Schmolzer is a recipient in of a Research Scholarship Award. In addition, he holds a Heart and Stroke Foundation/University of Alberta Professorship in Neonatal Resuscitation; this award helped establish the Centre for the Studies of Asphyxia and Resuscitation (CSAR).

78 Heart and Stroke Foundation Research Report Research Chairs and Professorships Research Chairs Title Type Province(s)/Territory(ies) Krahn, Andrew University of British Columbia Lear, Scott St. Paul s Hospital/ Simon Fraser University Becher, Harald University of Alberta Demchuk, Andrew University of Calgary Duff, Henry University of Calgary Kelly, Michael University of Saskatchewan Katz, Alan University of Manitoba Anand, Sonia McMaster University Goodman, Shaun University of Toronto McGillion, Michael McMaster University Mital, Seema Hospital for Sick Children Pickering, Geoffrey University of Western Ontario Tobe, Sheldon Northern Ontario School of Medicine Weitz, Jeffrey McMaster University Yusuf, Salim McMaster University Cox, Jafna Dalhousie University The Sauder Family/ Heart and Stroke Foundation Chair in Cardiology Cardiology British Columbia/Yukon Pfizer/ Heart and Stroke Foundation Chair in Cardiovascular British Columbia/Yukon Cardiovascular Prevention Research Prevention Research Heart and Stroke Foundation Chair in Cardiolgy Alberta/Northwest Cardiovascular Research Territories/Nunavut Heart and Stroke Foundation Chair in Stroke Stroke Alberta/Northwest Research Territories/Nunavut Heart and Stroke Foundation Chair in Cardiolgy Alberta/Northwest Cardiovascular Research Territories/Nunavut Heart and Stroke Clinical Research Chair Clinical Stroke Saskatchewan Manitoba Research Chair in Primary Prevention Primary Prevention Manitoba Heart and Stroke Foundation / Michael G. Population Health Ontario DeGroote Chair in Population Health Research Heart and Stroke Foundation Polo for Cardiology Ontario Heart Chair Heart and Stroke Foundation / Michael G. Cardiac Nursing Ontario DeGroote Chair in Cardiovascular Nursing Heart and Stroke Foundation / Robert M. Cardiology Ontario Freedom Chair in Cardiovascular Science Heart and Stroke Foundation / Barnett-Ivey Chair Cardiology Ontario at the Robarts Research Institute Heart and Stroke Foundation / NOSM Chair in Aboriginal and Rural Health Heart and Stroke Foundation / J. Fraser Mustard Chair in Cardiovascular Research Heart and Stroke Foundation / Marion W. Burke Chair in Cardiovascular Disease Heart and Stroke Foundation Chair Endowed Chair in Cardiovascular Outcomes Research Aboriginal and Ontario Rural Health Cardiology Ontario Cardiology Ontario Cardiology Nova Scotia 72

79 Heart and Stroke Foundation Research Report Professorships Title Type Province(s)/Territory(ies) Humphries, Karin University of British Columbia UBC/Heart and Stroke Foundation Professorship in Women's Cardiovascular Health Women's Cardiovascular Health British Columbia/Yukon Teal, Philip University of British Columbia The Sauder Family/ Heart and Stroke Foundation Professorship in Clinical Stroke Research Clinical Stroke British Columbia/Yukon Bijoy K., Menon University of Calgary The Heart and Stroke Foundation/University of Calgary Professorship in Stroke Imaging Stroke Alberta/Northwest Territories/Nunavut Butcher, Ken University of Alberta Heart and Stroke Foundation Professorship in Stroke Research Stroke Alberta/Northwest Territories/Nunavut Chen, Wayne University of Calgary Heart and Stroke Foundation/Libin Cardiovascular Institute Professorship in Cardiovascular Research Cardiology Alberta/Northwest Territories/Nunavut Georg, Schmolzer University of Alberta The Heart and Stroke Foundation/University of Alberta Professorship in Neonatal Resuscitation Neonatal Resuscitation Alberta/Northwest Territories/Nunavut Hill, Michael University of Calgary Heart and Stroke Foundation/Hotchkiss Brain Institute Professorship in Stroke Research Stroke Alberta/Northwest Territories/Nunavut Typically, Research Chairs and Professorships are funded via an endowment from the provincial Foundations listed as well as endowments from other sources. 73

80 Heart and Stroke Foundation Research Report 74

81 APPENDIX E PROVINCIAL PERSONNEL AWARDS Photo: Dr. Clive Kearon (McMaster University) was the recipient in 2014 of a Career Investigator Award and a Grant-in-Aid recipient in

82 Heart and Stroke Foundation Research Report Alberta/Northwest Territories/Nunavut New Investigator Awards Awardee Research Institution Project Term $ Total $ Gordon, Grant University of Calgary Parallel control of the micro-vasculature by astrocytes and neurons. White, James University of Calgary MRI allocation of pacing targets in cardiac resynchronization therapy (MAPIT-CRT). 60, ,000 60, ,000 Manitoba Sanofi Canada - Heart and Stroke Foundation Manitoba Award in Cardiology Award: $10,000 Awardee Golian, Mehrdad Research Institution University of Manitoba Master s Student Award Award: $1,000 Awardee Supervisor Research Institution Jahan, Fahmida Wigle, Jeffrey St. Boniface Hospital Research Centre Dr. Dexter Harvey Award Award: $5,000 Awardee Edel, Andrea Research Institution University of Manitoba Ontario Career Investigator Awards Awardee Research Institution Project Term $ Total $ Austin, Peter C. Institute for Clinical Evaluative Sciences Statistical methods for cardiovascular research Beanlands, Rob S. B. University of Ottawa Metabolism, energetics and neurohormonal signaling Heart Institute and their response to therapy in dysfunctional myocardium. Bendeck, Michelle P. University of Toronto Cell adhesion signaling in the progression and complications of atherosclerosis. Bolz, Steffen-Sebastian University of Toronto Translating molecular mechanisms governing microvascular behaviour - a bench to bedside strategy Crowther, Mark A. St. Joseph's Healthcare Improving the quality of anticoagulant care for patients with cardiovascular disease. 83, ,000 83, ,500 83, ,000 83, ,000 83, ,000 76

83 Heart and Stroke Foundation Research Report Awardee Research Institution Project Term $ Total $ Cybulsky, Myron I. Toronto General Hospital Initiation of atherosclerosis: Mechanisms and cell biology Devereaux, Philip J. McMaster University Major vascular complications after noncardiac surgery Drangova, Maria Robarts Research Institute Cardiac imaging for therapy guidance and pre-clinical research studies. Feng, Qingping University of Western Mechanisms of heart failure Ontario Ferguson, University of Western Molecular regulation of G protein-coupled receptor Stephen S.G. Ontario signal transduction, desensitization and resensitization. Husain, Mansoor Toronto General Hospital Molecular studies of cardiac and vascular disease. Kapral, Moira K. Toronto General Hospital Evaluation of stroke care in Canada Kearon, Clive McMaster University Optimizing diagnosis and treatment of venous thromboembolism. Nanthakumar, Toronto General Hospital Human ventricular fibrillation, refibrillation, and Kumaraswamy cardiac arrest: mechanisms & modulation Park, David S. University of Ottawa Pathways which regulate neuronal death Rodger, Marc A. The Ottawa Hospital Venous thrombosis and thrombophilia Sweeney, Gary York University Cardiac remodelling by adipokines: mechanisms and pathophysiological significance in heart failure. 41, ,500 83, ,000 83, ,000 83, ,000 83, ,500 83, ,000 83, ,000 83, ,000 83, ,000 83, ,000 83, ,000 83, ,000 83, ,000 83, ,000 83, ,000 Clinician Scientist Awardee Research Institution Project Term $ Total $ Tu, Jack V. Institute for Clinical Evaluative Sciences Improving the quality of cardiovascular care in Canada Yang, Burton B. Sunnybrook Health Science The roles of MicroRNAs in regulating cell activities Centre and angiogenesis. Zhang, Shetuan Queen's University Molecular mechanisms of ion channel function in heart health and disease. Johri, Amer Queen's University Carotid artery plaque quantification to assess progression of atherosclerosis Ko, Dennis T. Institute for Clinical Improve the quality and outcomes of care of patients Evaluative Sciences with cardiovascular diseases. Mielniczuk, Lisa M. University of Ottawa Heart Cardiopulmonary energetics and metabolism in right Institute heart failure and pulmonary hypertension. Tang, Ada McMaster University Exercise and cardiovascular health after stroke. 70, ,000 80, ,000 80, ,000 70, ,000 77

84 Heart and Stroke Foundation Research Report Mid-Career Investigator Awardee Research Institution Project Term $ Total $ Alter, David A. Institute for Clinical Evaluative Sciences Characterizing the adherence phenotypes of populations with cardiovascular disease: Applications for health services research and interventions. Birnie, David H. University of Ottawa Heart Comprehensive program of patient orientated research in Institute cardiac arrhythmia. Booth, Gillian L. St. Michael's Hospital Population-based strategies for reducing the burden of cardiovascular disease due to diabetes. Chen, Hsiao-Huei Ottawa Hospital Research A systems approach to stroke recovery. Institute 2018 Fowler, Robert A. Sunnybrook Health Science Improving end-of-life care for Canadians with heart disease Centre and stroke. Gollob, Michael H. University Health Network Novel molecular targets and mechanisms of human atrial fibrillation. Healey, Jeff S. Hamilton Health Sciences Detection and treatment of sub-clinical atrial fibrillation to prevent stroke. Lok, Charmaine E. Toronto General Hospital A program of cardiovascular health improvement in chronic and endstage kidney disease Retnakaran, Ravi R. Mount Sinai Hospital The early natural history and pathophysiology of cardiometabolic disease in mother and child St. Lawrence, Keith S. Lawson Health Research Developing non-invasive optical techniques to detect Institute cerebral ischemia in critical-care patients. Steinman, David A. University of Toronto Hemodynamic and geometric risk factors: Turning theory into practice. Wu, Lingyun Lakehead University Methylgloxal metabolism and vascular remodelling. 80, ,000 80, ,000 80, ,000 80, ,000 80, ,000 80, ,000 80, ,000 80, ,000 80, ,000 80, ,000 80, ,000 80, ,000 Summer Medical Student Scholarship Awardee Supervisor Research Institution $ Atkins, Paul Spence, David Robarts Research Institute 2,500 Chetan, Devin Mondal, Tapas McMaster University 2,500 Fok, Kai-Ho Wintersperger, Bernd University of Toronto 2,500 Isleam, Olgun Spence, David Robarts Research Institute 2,500 Kanda, Pushpinder Davis, Darryl University of Ottawa 5,000 Lai, Paris Lanctot, Krista University of Toronto 5,000 Lechtman, Eli Moody, Alan University of Toronto 2,500 Li, Olivia Kapral, Moira University of Toronto 2,500 Ouyang, Ben Kullervo, Hynynen University of Toronto 5,000 Qaddaoura, Amro Baranchuk, Adrian Queen's University 5,000 Saldanha, Lisa Lindsey, Thomas University of Toronto 5,000 Tao, Jiayi Roche-Nagle, Graham University of Toronto 2,500 Toth, Zsolt Tobe, Sheldon Northern Ontario School of Medicine 12,000 Yeh, Calvin Weitz, Jeffrey McMaster University 2,500 78

85 Heart and Stroke Foundation Research Report Newfoundland and Labrador Awardee Research Institution $ Graduate Scholarship Grant - NeuroFIT Program Keith Griffiths Memorial Scholarship Undergraduate Nursing Award in Cardiovascular Health Undergraduate Nursing Award in Stroke Memorial University of Newfoundland Memorial University of Newfoundland Memorial University of Newfoundland Memorial University of Newfoundland Memorial University of Newfoundland 1,500 3,500 1,500 1,500 1,500 Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Social, Cultural, Environmental and Population Health 79

86 Heart and Stroke Foundation Research Report 80

87 APPENDIX F OTHER PROVINCIAL INITIATIVES Photo: Dr. Ada Tang (McMaster University) was the recipient in 2014 of a Clinician Scientist Award titled Exercise and cardiovascular health after stroke.

88 Heart and Stroke Foundation Research Report British Columbia/Yukon HSF-UBC Cardiology Research Partnership: Cardiology Academic Practice Plan (CAPP) As part of its mandate to support innovative research and its application to improve the health of Canadians, Heart and Stroke Foundation, BC & Yukon, has partnered with the University of British Columbia s Division of Cardiology to support research by early career cardiologists. Grant: $200,000 Principal Investigator Davis, Margot Deyell, Marc Grewal, Jasmine Ong, Kevin Ramanathan, Krishnan Saw, Jacqueline Sedlak, Tara Taylor, Carolyn Tsang, Michael Wood, David Research Institution Vancouver General Hospital St. Paul's Hospital St. Paul's Hospital St. Paul's Hospital St. Paul's Hospital Vancouver General Hospital Vancouver General Hospital St. Paul's Hospital Vancouver General Hospital Vancouver General Hospital *HSF contributes $200,000 annually in partnership with UBC Division of Cardiology to support research of early career cardiologists. Alberta/Northwest Territories/Nunavut Seed Grants Principal Investigator Research Institution Project $ Carson, Valerie University of Alberta Parents role in establishing healthy active living behaviours in young children. Chowdhury, Turin University of Calgary Lifetime risk of cardiovascular diseases and life expectancy for patients with these conditions. Jurasz, Paul University of Alberta Neutralization of angiostatin for the promotion of therapeutic angiogenesis. Marchant, David University of Alberta Matrix metalloproteinase-12 regulates antiviral immunity during viral myocarditis. Oudit, Gavin University of Alberta Fingerprinting of plasma renin-angiotensin system peptides in acute and chronic heart failure patients. 45,000 42,500 45,000 44,000 45,000 Bridge Funding Principal Investigator Research Institution $ Shuaib, Ashfaq University of Alberta 70,000 82

89 Heart and Stroke Foundation Research Report Manitoba Primary Prevention Challenge Grant Principal Investigator Research Institution Project Term $ Total $ Ahmed, Rashid CancerCare Manitoba Time trends in prevalence of lifestyle risk factors for cardiac and other chronic diseases among Manitoba youth, and the association with changes in school programs and policies. Slater, Joyce University of Manitoba Identifying critical food literacy competencies for preventing obesity and chronic diseases in Manitoba youth: A delphi study. 40,000 80,000 39,971 77,551 Ontario Bridge Grant Grant: $70,000 Principal Investigator Carrier, Marc Corrales-Medina, Vincente Heckman, George A.W. Kapral, Moira K. McPherson, Ruth Ni, Heyu Wisenberg, Gerald You, John Research Institution Ottawa Hospital Research Institute Ottawa Hospital Research Institute University of Waterloo Toronto General Hospital University of Ottawa Heart Institute St. Michael's Hospital Lawson Health Research Institute McMaster University 83

90 Heart and Stroke Foundation Research Report Quebec Heart and Stroke Foundation, Quebec Awards for Excellence in Research Awards for excellence highlighting the outstanding contribution of researchers. Principal Investigator Award Research Institution Project $ Bonnet, Sébastien Louise Rousselle-Trottier Award Institut universitaire de cardiologie et de pneumologie de Québec Role for DNA damage signalling in pulmonary arterial hypertension. Bousette, Nicolas Jacques de Champlain Montreal Heart Institute The protective role of perilipin-2 in diabetic Award cardiomyopathy. Hamel, Edith John J. Day Award McGill University The cellular basis of neurovascular coupling in the cerebral cortex. Levin, Mindy John J. Day Award McGill University Corticospinal contribution to spasticity and disordered motor control. Sebire, Guillaume Jonathan-Ballon Award Université de Sherbrooke Rôle de la réponse inflammatoire maternofoetale dans la physiopathologie des accidents vasculaires cérébraux (AVC) périnatals. 10,000 10,000 10,000 10,000 10,000 Training bursaries for PhD students in Cardiovascular and Stroke Research Partnership between the Fonds de recherche du Québec en santé (FRQS) and the Heart and Stroke Foundation, Quebec. The partners offer training bursaries for PhD students working with researchers receiving a Grant-in-Aid from HSF,Q. Principal $ Investigator El Husseini, Diala 6,667 Huguet, Jade 6,600 Nova Scotia Dr. Gregory Ferrier Award Grant: $5,000 Awardee Research Institution Project Waisman, David Dalhousie University Defining the physiological function of S100A10 with the S100A10 knockout mouse. BrightRed Graduate Research Award Grant: $5,000 Awardee Supervisor(s) Research Institution Project Durrieu, Ludovic Waisman, David Dalhousie University Implication of S100A10 in the progression and severity of stroke. Falkenham, Alec Legare, Jean Francois Dalhousie University Resident cardiac macrophages as a target for reducing cardiac injury in obesity. Kraeutner, Sarah Boe, Shaun Dalhousie University Applications of motor imagery in stroke rehabilitation: Investigating the impact of parietal lobe damage on motor imagery ability. Mcisaac, Jessie-Lee Kirk, Sara Dalhousie University Facilitating knowledge exchange within school health systems. Rubinfeld, Lindsay Eskes, Gail Dalhousie University The Dalhousie computerized attention battery: validation against traditional neuropsychological testing instruments. 84

91 APPENDIX G RESEARCH COMMITTEE MEMBERS Photo: Dr. Grant Pierce (University of Manitoba) served on the Heart and Stroke Foundation of Canada s Scientific Review Committee in.

92 Heart and Stroke Foundation Research Report Council on Mission: Priorities, Advice, Science and Strategy (CoMPASS) Hon. Mary Collins, PC, Co-Chair BC Healthy Living Alliance Mary Lewis, Co-Chair Heart and Stroke Foundation Penny Ballantyne Government of the Northwest Territories Penny Ballem, MD, MSc City of Vancouver Rob Beanlands, MD University of Ottawa Heart Institute Sandra E. Black, O.Ont., MD Sunnybrook Research Institute Adalsteinn D. Brown, PhD University of Toronto Roy Cameron, PhD Homewood Health Centre James Christenson, MD Vancouver General Hospital Robert Côté, MD Montreal General Hospital Jafna Cox, MD Queen Elizabeth II Health Sciences Centre Jean-Pierre Després, PhD Institut universitaire de cardiologie et de pneumologie de Québec David Hammond, PhD University of Waterloo Mary L Abbé, PhD University of Toronto Kelly Lendsay, Aboriginal Human Resource Council Peter Liu, MD University of Ottawa Heart Institute Michael McGillion, PhD McMaster University J. Geoffrey Pickering, MD, PhD Robarts Research Institute Andrew Pipe, CM, MD, LLD, DSc University of Ottawa Heart Institute Kim Raine, PhD University of Alberta Jeffrey Reading, PhD Dalla Lana School of Public Health Institute for Indigenous Health Mike Sharma, MD, MSc McMaster University Eldon R. Smith, O.C., MD University of Calgary John C. Spence, PhD University of Alberta Glen Tibbits, PhD Simon Fraser University Jack V. Tu, MD, PhD Institute for Clinical Evaluative Sciences Thomas Warshawski, MD University of British Columbia Glenda Yeates Former Deputy Minister, Health Canada 86

93 Heart and Stroke Foundation Research Report Scientific Review Committee Leadership Rob Beanlands, MD, Chair University of Ottawa Heart Institute Glen F. Tibbits, PhD, Vice Chair Simon Fraser University Clinical cardiovascular and cerebrovascular research: mechanistic studies and clinical trials / health services research A Michael D. Hill, MD, Chair Foothills Hospital Ratika Parkash, MD, Deputy Chair Queen Elizabeth II Health Sciences Centre Clinical cardiovascular and cerebrovascular research: mechanistic studies and clinical trials / health services research B Andrew Krahn, MD, Chair Vancouver General Hospital Jeff Healey, MD, Deputy Chair McMaster University Integrative studies: genetic manipulations / imaging / bioengineering Éric Larose, DVM, MD, Chair Hôpital Laval Howard M. Leong-Poi, MD, Deputy Chair St. Michael s Hospital Basic science stroke / neurophysiology / neuroregulation James Eubanks, PhD, Chair Toronto Western Hospital Roger Thompson PhD, Deputy Chair University of Calgary Molecular, biochemical and cellular physiological approaches to cardiovascular health and disease, vascular disorders A Ian Dixon, PhD, Chair St. Boniface Hospital Research Centre Stéphanie Lehoux, PhD, Deputy Chair McGill University Cardiac arrhythmias, cardiac mechanics, electrophysiological approaches to cardiovascular health and disease, ischemia related disorders B Terence Hébert, PhD, Chair McGill University Reinhart Reithmeier, PhD, Deputy Chair University of Toronto Cardiovascular complications associated with obesity/diabetes, metabolism, and cardiac development/remodeling C Jason R.B. Dyck, PhD, Chair University of Alberta Ross Feldman, MD, Deputy Chair Robarts Research Institute Molecular basis of cardiac and vascular function Lorrie Kirshenbaum, PhD, Chair St. Boniface Hospital Research Centre Marek Michalak, PhD, Deputy Chair University of Alberta Thrombosis / lipids and lipoproteins / fundamental nutrition research Ed Pryzdial, PhD, Chair University of British Columbia Nica Borradaile, PhD, Deputy Chair University of Western Ontario Health services and public health, health behaviour; health psychology Alexander Clark, PhD, Chair University of Alberta Jonathan McGavock, PhD, Deputy Chair University of Manitoba Emerging Research Leaders Initiative Peter Backx, DVM, PhD, Chair University of Toronto Martin Kolb, MD, PhD, Deputy Chair McMaster University Population Level Nutrition Intervention Nazeem Muhajarine, PhD, Chair University of Saskatchewan Grant Pierce, PhD, Deputy Chair St. Boniface Research Centre Canadian Alliance for Healthy Hearts and Minds Initiative Robert D. Reid, PhD, Chair University of Ottawa Heart Institute Budget Review Committee Gary Newton, MD, Chair Mount Sinai Hospital Eric Accili, PhD, Deputy Chair University of British Columbia 87

94 Heart and Stroke Foundation Research Report Provincial Research Advisory Committee Chairs Heart and Stroke Foundation, Alberta, Northwest Territories and Nunavut Research and Medical Advisory Committee Gary Lopaschuk, PhD, Chair University of Alberta Heart and Stroke Foundation, Manitoba Research Advisory Committee Mark G. Torchia, MS, PhD, Chair University of Manitoba Heart and Stroke Foundation, Ontario Research Advisory Committee J. Geoffrey Pickering, MD, PhD, Chair Robarts Research Institute Comité scientifique de la Fondation des maladies du coeur du Québec Pedro D Orléans-Juste, PhD, Président Université de Sherbrooke Heart and Stroke Foundation, New Brunswick Medical Advisory Committee Marc Pelletier, MD, Chair New Brunswick Heart Centre Heart and Stroke Foundation, Nova Scotia Research Advisory Committee Stephen Phillips, MBBS, Chair Dalhousie University 88

95 APPENDIX H DEFINITION OF HEALTH RESEARCH THEMES Photo: Krystin van den Born, stroke survivor.