Gastric and Colon Cancer. Dr. Andres Wiernik 2017
|
|
- Adam French
- 5 years ago
- Views:
Transcription
1 Gastric and Colon Cancer Dr. Andres Wiernik 2017
2 GASTRIC CANCER
3 Gastric Cancer Classification Epidemiology General principles of Management
4 25% GE Junction Gastric Cancer 75% Gastric Cancer
5 Epidemiology Gastric Cancer Word Incidence: 950,000 / year (4 th ) World Mortality 720,000 / year (2 nd ) NOT a big problem in the USA A HUGE problem in the rest of the world
6
7
8
9
10 Risk Factors Gastric Cancer Helicobacter pylori? EBV - Epstein Barr Virus Tobacco Low consumption of fruits High intake of salts, nitrates, and pickled foods Obesity 1-3% Hereditary: Hereditary diffuse gastric cancer Gastric adenocarcinoma proximal polyposis of the stomach Familial intestinal gastric cancer.
11 Helicobacter pylori 1983 Identified for the 1 st time 1994 WHO Definitive Carcinogen
12 NEJM, 2001
13
14 Management Gastric Cancer Surgery is the only curative treatment. Locally advanced disease: neoadjuvant or adjuvant therapy (chemotherapy) + Surgery Metastatic Disease Palliative chemotherapy Molecular Therapy (HER-2 and VEGFR2) Median OS ~ 1 year
15 ~500 Patients with Resectable Gastric Cancer Magic Trial NEJM, % 23%
16 Management Gastric Cancer Surgery is the only curative treatment. Locally advanced disease: neoadjuvant or adjuvant therapy (chemotherapy) + Surgery Metastatic Disease Palliative chemotherapy Median OS ~ 1 year
17 Chemotherapy in Metastatic Gastric Cancer
18 Any Target Therapy in Metastatic Gastric Cancer? Anti HER-2 (POSITIVE in 20-25% of Gastric Cancer) Anti VEGFR-2
19 +300 Patients with metastatic HER2+ Gastric Cancer TOGA Trial Lancet, 2010
20 VEGFR Family of Receptors Ramucirumab
21 +600 Patients with metastatic Gastric Cancer Paclitaxel +/- Ramucirumab RAINBOW Trial Lancet Onc, 2014 OS 9.6 months OS 7.4 months
22 Colon Cancer
23 Colon Cancer Epidemiology General principles of Management
24 Epidemiology Colon Cancer Word Incidence: ~ 1,200,000 / year (3 rd ) World Mortality 600,000 / year (4 th ) Incidence strongly varies globally and is closely linked to elements of a so-called western lifestyle Men > Women Median age Dx: ~ 70 years old
25
26
27
28
29 NEJM 2016
30
31
32 Risk Factors Colon Cancer
33 Sporadic Colon Cancer BOARDS: 55 yo with Bacteremia *** Streptococcus bovis Clostridium septicum
34 Sporadic >80% Colorectacal Cancer Genetic ~5-10% FAP / Familial Adenomatous Polyposis Hereditary Non-Polyposis Colon Cancer or Lynch Syndrome (5% of all Colon Cancer) Others (???)
35 Combined data on 44,788 pairs of twins listed in the Swedish, Danish, and Finnish twin registries in order to assess the risks of cancer at 28 anatomical sites for the twins of persons with cancer
36
37
38 Familial forms of Colon Cancer Hereditary Colon Cancer: FAP / Familial Adenomatous Polyposis 100s to 1000s of polyps 100% incidence of colon cancer without prophylaxis Hereditary Non-Polyposis Colon Cancer or Lynch Syndrome 5% of ALL Colon Cancers Younger age Right sided lesions Associated with other adenocarcinomas Breast Ovary Small Bowel or Stomach Kidney NO preceeding polyposis
39 FAP Familial Adenomatous Polyposis
40 FAP Familial Adenomatous Polyposis
41 FAP Familial Adenomatous Polyposis
42 Colon Cancer Screening based on FH: Scenario When to start? Comments 1 st degree relative younger than 60 yo * Two 1 st degree relatives at any age * 1 st degree relative older than 60 yo Age 40 or 10 years younger Age 40 or 10 years younger Age 50 Screen every 5 years (not 10) Screen every 5 years (not 10) Every 10 (average risk) 2 nd or 3 rd Degree Age 50 Every 10 (average risk) * CRC or Adenomatous Polyps
43 Staging of Colon Cancer IV III II I
44
45 Treatment Summary of Colorectal Cancer Main treatment Surgical Resection Hemicolectomy + LN dissection Neoadjuvant radiotherapy for patients with rectal cancer), Adjuvant chemotherapy (for patients with stage III/IV and high-risk stage II colon cancer).
46 Staging of Colon Cancer IV III II I
47 Management of Stage I and II Colon Cancer Hemicolectomy + LN dissection II I
48 Management of Stage IIII Colon Cancer 1) Hemicolectomy + LN dissection 2) Adjuvant Chemotherapy III (FOLFOX)
49 Management of Stage IV Colon Cancer IV 1) Surgery? Only if oligometastatic disease 2) Palliative Chemotherapy +/- Biologics
50
51 Treatment of stage IV Colon Cancer Chemotherapy: FOLFOX FOLFIRI Biologics: Anti-VEGF Bevacizumab (Avastin) Anti-EGFR monoclonal antibodies Cetuximab Panitumumab Regorafenib Ramucirumab trifluridine-tipiracil (LONSURF) Immunotherapy (Nivolumab or Pembrolizumab)
52 VEGFR Family of Receptors
53
54 Chemotherapy + Avastin
55 EGFR Pathway
56 Chemotherapy + anti-egfr (Cetuximab) JCO, 2015
57 EGFR Pathway KRAS MUTATION (30-50%)
58 Chemotherapy + Cetuximab in KRAS MUTATED JCO, 2015
59 Thank you!
60 Case: 55 yo male diagnosed with colon cancer on screening. Undergoes surgical resection and he is found to have a 2 cm tumor (invading the muscularis) with negative LNs. Adjuvant chemo? What about radiation?
61 Case: 55 yo male presents with acute abdomen. Undergoes laparotomy and is found to have a perforated bowel in addition to a 2 cm invading the muscularis which pathology reports is consistent with adenocarcinoma of the colon measuring 2 cm. 15 lymph nodes were resected and these are all negative for tumor. Adjuvant chemo? What about radiation?
62 Who gets adjuvant chemo in Colon Cancer? Stage 3 or higher: FOLFOX High risk stage 2: 5-FU or Capecitabine Grade 3-4 (exclusive of those cancers that are MSI- H) Lymphatic/vascular invasion Bowel obstruction < 12 lymph nodes examined Perineural invasion Localized perforation or close Indeterminate or positive margins.
63 MKSAP #67 67 yo man s/p right hemicolectomy + adjuvant chemotherapy for stage III colon cancer 3 years ago Annual CT and surveillance: Normal CEA 1 year ago: 2.4 Today: CEA 10.1 (nl=less than 2.1) CT scan: Solitary liver lesion
64 Next step in management? 1) Chemoembolization 2) Biopsy 3) Ethanol ablation 4) Systemic chemotherapy 5) Surgical Resection
65 Metastatic Stage IV Colon Cancer Who gets Surgery in stage IV Colon Cancer? Single Liver lesion or Lung Only RESECTION! (with curative intent!!!) Do PET before (ONLY indication for PET in Colon Ca) Obstructive palliative Sx Colostomy
66 MKSAP #77 56 yo woman with screening colonoscopy Mass is found 10 cms from anal verge Bx: Moderately differentiated adenocarcinoma Rectal US: Tumor extends into perirectal fat but not LN involvement CT C/A/P: No metastatic disease
67 Next Step in Management 1. Chemotherapy followed by surgery 2. Surgery follow by chemotherapy 3. Chemo +radiation followed by surgery followed by adjuvant chemotherapy 4. Surgery followed by radiation
COLORECTAL CANCER CASES
COLORECTAL CANCER CASES Case #1 Case #2 Colorectal Cancer Case 1 A 52 year-old female attends her family physician for her yearly complete physical examination. Her past medical history is significant
More informationBy: Tania Cortas, MD Arizona Oncology 03/10/2015
By: Tania Cortas, MD Arizona Oncology 03/10/2015 Epidemiology In the United States, CRC incidence rates have declined about 2 to 3 percent per year over the last 15 years Death rates from CRC have declined
More informationA Brief Overview of Screening and Management of Colorectal Cancer
A Brief Overview of Screening and Management of Colorectal Cancer Gentry King MD Assistant Professor Hematology and Medical Oncology University of Colorado Disclosures Nothing to disclose Objectives Review
More information11/21/13 CEA: 1.7 WNL
Case Scenario 1 A 70 year-old white male presented to his primary care physician with a recent history of rectal bleeding. He was referred for imaging and a colonoscopy and was found to have adenocarcinoma.
More informationADVANCES IN COLON CANCER
ADVANCES IN COLON CANCER Peter T. Silberstein, M.D., FACP Professor, Creighton University Chief Hematology/Oncology UNIVERSAL SCREENING FOR LYNCH SYNDROME OF ALL PATIENTS WITH COLON CANCER ADOPTED BY CHI
More informationADJUVANT CHEMOTHERAPY...
Colorectal Pathway Board: Non-Surgical Oncology Guidelines October 2015 Organization» Table of Contents ADJUVANT CHEMOTHERAPY... 2 DUKES C/ TNM STAGE 3... 2 DUKES B/ TNM STAGE 2... 3 LOCALLY ADVANCED
More informationUPDATE IN THE MANAGEMENT AND TREATMENT OF COLORECTAL CANCER. Edwin A. Empaynado, MD Advocare Colon and Rectal Surgical Specialists
UPDATE IN THE MANAGEMENT AND TREATMENT OF COLORECTAL CANCER Edwin A. Empaynado, MD Advocare Colon and Rectal Surgical Specialists WHAT IS COLON CANCER? WHAT CAUSES COLORECTAL CANCER? WHAT ARE THE RISK
More informationCaring for a Patient with Colorectal Cancer. Objectives. Poll question. UNC Cancer Network Presented on 10/15/18. For Educational Use Only 1
Caring for a Patient with Colorectal Cancer Tammy Triglianos RN, APRN-BC, AOCNP Nurse Practitioner, GI Oncology 10/15/2018 Objectives Describe common signs and symptoms of colorectal cancer Understand
More informationTHE CROSSROADS: Drug Development, Biomarkers, and Colorectal Cancer
THE CROSSROADS: Drug Development, Biomarkers, and Colorectal Cancer SANJAY GOEL, M.D., M.S. PROFESSOR OF MEDICINE ALBERT EINSTEIN COLLEGE OF MEDICINE MONTEFIORE MEDICAL CENTER DEPT. OF ONCOLOGY JUN 22,
More informationCHEMOTHERAPY FOR COLON CANCER OUTLINE OF TODAY S TALK. Colon Cancer Epidemiology 11/6/2012 GATRA/GCCR FALL CONFERENCE NOVEMBER 14 16, 2012
CHEMOTHERAPY FOR COLON CANCER JONATHAN C. BENDER,MD MEDICAL DIRECTOR OF PIEDMONT FAYETTE CANCER CENTER OUTLINE OF TODAY S TALK 1. Overview of Colon Cancer in the US 2. Colon Cancer staging and risks of
More informationIndex. Note: Page numbers of article titles are in boldface type.
Index Note: Page numbers of article titles are in boldface type. A Abdominal drainage, after hepatic resection, 159 160 Ablation, radiofrequency, for hepatocellular carcinoma, 160 161 Adenocarcinoma, pancreatic.
More informationNavigators Lead the Way
RN Navigators Their Role in patients with Cancers of the GI tract Navigators Lead the Way Nurse Navigator Defined Nurse Navigator A clinically trained individual responsible for the identification and
More informationPRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES
PRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES GASTROINTESTINAL RECTAL CANCER GI Site Group Rectal Cancer Authors: Dr. Jennifer Knox, Dr. Mairead McNamara 1. INTRODUCTION 3 2. SCREENING AND
More informationADVANCES IN COLORECTAL CANCERS IS THERE HOPE? Dr Lim Hwee Yong Medical Oncologist
ADVANCES IN COLORECTAL CANCERS IS THERE HOPE? Dr Lim Hwee Yong Medical Oncologist limhweeyong@live.com CRC: Epidemiology in 2012 Third most common cancer diagnosis in US [1] Estimated 143,460 new cases
More informationColon, or Colorectal, Cancer Information
Colon, or Colorectal, Cancer Information Definition Colon, or colorectal, cancer is cancer that starts in the large intestine (colon) or the rectum (end of the colon). Other types of cancer can affect
More informationGASTROINTESTINAL MALIGNANCIES
Outline GASTROINTESTINAL MALIGNANCIES Bassel F. El-Rayes Winship Cancer Institute Emory University Colorectal Cancer Pancreas Cancer Gastric Cancer Hepatobiliary Cancer Anal Cancer Introduction Epidemiology
More informationCOLORECTAL CARCINOMA
QUICK REFERENCE FOR HEALTHCARE PROVIDERS MANAGEMENT OF COLORECTAL CARCINOMA Ministry of Health Malaysia Malaysian Society of Colorectal Surgeons Malaysian Society of Gastroenterology & Hepatology Malaysian
More informationNATIONAL INSTITUTE FOR HEALTH AND CARE EXCELLENCE. Health Technology Appraisal
NATIONAL INSTITUTE FOR HEALTH AND CARE EXCELLENCE Health Technology Appraisal Nivolumab for previously treated metastatic colorectal cancer with high microsatellite instability or mismatch repair deficiency
More informationDr. Andres Wiernik. Lung Cancer
Dr. Andres Wiernik Lung Cancer Lung Cancer Facts - Demographics World Incidence: 1 8 million / year World Mortality: 1 6 million / year 5-year survival rates vary from 4 17% depending on stage and regional
More informationDisclosure. Nothing to Disclose Will not be discussing off label use of any of the medications
Disclosure Nothing to Disclose Will not be discussing off label use of any of the medications Where s Cranbrook? Follow Up of Colorectal Cancer Stage 0 (in-situ disease) and Stage I (T1-2 N0) Follow up
More informationCASE STUDIES IN COLORECTAL CANCER: A ROUNDTABLE DISCUSSION
CASE STUDIES IN COLORECTAL CANCER: A ROUNDTABLE DISCUSSION PROVIDED AS AN EDUCATIONAL SERVICE BY THE INSTITUTE FOR CONTINUING HEALTHCARE EDUCATION SUPPORTED BY AN EDUCATIONAL GRANT FROM GENENTECH LEARNING
More information2014/2015 FCDS Educational Webcast Series
2014/2015 FCDS Educational Webcast Series February 19, 2015 Steven Peace, CTR 2015 Update; Background, Anatomy, Risk Factors, Screening Guidelines, MPH Rules Review AJCC TNM 7 th ed, SS2000, CSv02.05 and
More information8. The polyp in the illustration can be described as (circle all that apply) a. Exophytic b. Pedunculated c. Sessile d. Frank
Quiz 1 Overview 1. Beginning with the cecum, which is the correct sequence of colon subsites? a. Cecum, ascending, splenic flexure, transverse, hepatic flexure, descending, sigmoid. b. Cecum, ascending,
More informationDisclosures. Colorectal Cancer Update GAFP November Risk Assessment. Colon and Rectal Cancer The Challenge. Issues in Colon and Rectal Cancer
Disclosures Colorectal Cancer Update GAFP November 2006 Robert C. Hermann, MD Georgia Center for Oncology Research and Education Northwest Georgia Oncology Centers, PC WellStar Health System Marietta,
More informationDavid P. Ryan, M.D. Clinical Director, MGH Cancer Center Chief, Hematology-Oncology, MGH
Colon Cancer 2015 David P. Ryan, M.D. Clinical Director, MGH Cancer Center Chief, Hematology-Oncology, MGH Colon Cancer Case presentation 72yo woman presented 1/03 abd discomfort and nausea Found to have
More informationThird Line and Beyond: Management of Refractory Colorectal Cancer
Third Line and Beyond: Management of Refractory Colorectal Cancer George A. Fisher MD PhD Stanford University 1 Overview Defining the chemo refractory and intolerant Agents approved in 3 rd line setting
More informationObjectives. Briefly summarize the current state of colorectal cancer
Disclaimer I do not have any financial conflicts to disclose. I will not be promoting any service or product. This presentation is not meant to offer medical advice and is not intended to establish a standard
More informationLocally Advanced Colon Cancer. Feiran Lou MD. MS. Richmond University Medical Center Department of Surgery
Locally Advanced Colon Cancer Feiran Lou MD. MS. Richmond University Medical Center Department of Surgery Case 34 yo man presented with severe RLQ abdominal pain X 24 hrs. No nausea/vomiting/fever. + flatus.
More informationBreast Cancer. Dr. Andres Wiernik 2017
Breast Cancer Dr. Andres Wiernik 2017 Agenda: The Facts! (Epidemiology/Risk Factors) Biological Classification/Phenotypes of Breast Cancer Treatment approach Local Systemic Agenda: The Facts! (Epidemiology/Risk
More informationColorectal cancer Chapelle, J Clin Oncol, 2010
Colorectal cancer Chapelle, J Clin Oncol, 2010 Early-Stage Colorectal cancer: Microsatellite instability, multigene assay & emerging molecular strategy Asit Paul, MD, PhD 11/24/15 Mr. X: A 50 yo asymptomatic
More informationCOLON CANCER CARE GUIDELINES NON-METASTATIC DISEASE
COLON CANCER CARE GUIDELINES NON-METASTATIC DISEASE Guideline Authors: Todd S. Crocenzi, M.D.; Mark Whiteford, M.D.; Matthew Solhjem, M.D.; Carlo Bifulco, M.D.; Melissa Li, M.D.; Christopher Cai, M.D.;
More informationINTERACTIVE SESSION 2
INTERACTIVE SESSION 2 2 patients with lung metastases, with complete response after oncologic treatment - Clinical Case Presentation: Dr. Esther Casado Dr. Sergi Call - Expert Opinion: Dr. Raúl Embún Dr.
More informationColorectal Cancer: Lumping or Splitting? Jimmy J. Hwang, MD FACP Levine Cancer Institute Carolinas HealthCare System Charlotte, NC
Colorectal Cancer: Lumping or Splitting? Jimmy J. Hwang, MD FACP Levine Cancer Institute Carolinas HealthCare System Charlotte, NC 2 Epidemiology Colorectal Cancer is the 2 nd Leading Cause of Cancer-related
More informationIndex. Note: Page numbers of article titles are in boldface type.
Index Note: Page numbers of article titles are in boldface type. A Abdominal surgery prior as factor in laparoscopic colorectal surgery, 554 555 Abscess(es) CRC presenting as, 539 540 Adenocarcinoma of
More informationColorectal Cancer Update Dr. Barb Melosky
Colorectal Cancer Update 2017 Dr. Barb Melosky bmelosky@bccancer.bc.ca Disclosure Research Support/P.I. Honoraria/Advisory Board Bayer Roche, Amgen, Bayer, Lilly Objectives 1) Demonstrate knowledge of
More informationCOLORECTAL CANCER 44
COLORECTAL CANCER 44 Colorectal Cancer Highlights from the 2009 Annual Meeting of the American Society of Clinical Oncology Edited by Stuart M. Lichtman, MD Memorial Sloan-Kettering Cancer Center Commack,
More informationThis is the portion of the intestine which lies between the small intestine and the outlet (Anus).
THE COLON This is the portion of the intestine which lies between the small intestine and the outlet (Anus). 3 4 5 This part is responsible for formation of stool. The large intestine (colon- coloured
More informationTreatment of Advanced Colorectal Cancer
Treatment of Advanced Colorectal Cancer Alexis D. Leal, M.D. Assistant Professor, GI Medical Oncology University of Colorado Cancer Center Disclosures None Objectives Review the basics of advanced colorectal
More informationWhat s New in Colon Cancer? Therapy over the last decade
What s New in Colon Cancer? 9/19/2014 Michael McNamara, MD Therapy over the last decade Cytotoxic chemotherapy - 5FU ( Mayo, Roswell, Infusional) - Xeloda (01 ) - Oxaliplatin (02 ) - Irinotecan (96 ) Anti-
More informationCOLON CANCER PROFILE 2012} Cancer Outcomes Analysis Report. The Institute for. Cancer Care
COLON CANCER PROFILE 2012} Cancer Outcomes Analysis Report The Institute for Cancer Care FACT} People with a first-degree relative (parent, sibling, or children) who has colon cancer are between two and
More informationBOWEL CANCER. Causes of bowel cancer
A cancer is an abnormality in an organ that grows without control. The growth is often quite slow, but will continue unabated until it is detected. It can cause symptoms by its presence in the organ or
More informationCetuximab with Chemotherapy as Treatment for Stage III Colon or Metastatic Colorectal Cancer
Cetuximab with Chemotherapy as Treatment for Stage III Colon or Metastatic Colorectal Cancer Cetuximab with Chemotherapy (CT) as First-Line Treatment for Metastatic Colorectal Cancer (mcrc): Analysis of
More informationState of the Art: Colorectal Cancer Liver Metastasis Dr. Iain Tan
State of the Art: Colorectal Cancer Liver Metastasis Dr. Iain Tan Consultant GI Medical Oncologist National Cancer Centre Singapore Clinician Scientist, Genome Institute of Singapore OS (%) Overall survival
More informationColorectal Cancer Treatment
Colorectal Cancer Treatment Syed Husain, MD, FACS, FASCRS Assistant Professor of Surgery Department of Surgery Division of Colon and Rectal Surgery The Ohio State University Wexner Medical Center Introduction
More informationColorectal Cancer Treatment
Colorectal Cancer Treatment Introduction Scope of the problem Screening protocols Syed Husain, MD, FACS, FASCRS Assistant Professor of Surgery Department of Surgery Division of Colon and Rectal Surgery
More informationTreatment strategy of metastatic rectal cancer
35.Schweizerische Koloproktologie-Tagung Treatment strategy of metastatic rectal cancer Gilles Mentha University hospital of Geneva Bern, January 18th, 2014 Colorectal cancer is the third most frequent
More informationColorectal Cancer Therapy and Associated Toxicity
Colorectal Cancer Therapy and Associated Toxicity Mountain States Cancer Conference November 6, 2010 Colin D. Weekes, M.D., Ph.D Assistant Professor University of Colorado GI Cancers Are Common 2009 Estimated
More informationColon, Rectum, and Appendix
Colon, Rectum, and Appendix 2011 Reporting Requirements and CSv02.03.02 NCCN/ASCO Treatment Guidelines by Stage FCDS 2011 Educational Webcast Series September 15, 2011 Steven Peace, CTR Presentation Outline
More informationColon, Rectum, and Appendix. Presentation Outline. Overview Tumor Characteristics
Colon, Rectum, and Appendix 2011 Reporting Requirements and CSv02.03.02 NCCN/ASCO Treatment Guidelines by Stage FCDS 2011 Educational Webcast Series September 15, 2011 Steven Peace, CTR Presentation Outline
More informationAdjuvant Chemotherapy for Rectal Cancer: Are we making progress?
Adjuvant Chemotherapy for Rectal Cancer: Are we making progress? Hagen Kennecke, MD, MHA, FRCPC Division Of Medical Oncology British Columbia Cancer Agency October 25, 2008 Objectives Review milestones
More informationCOME HOME Innovative Oncology Business Solutions, Inc.
COME HOME Rectal Cancer Pathway V8, April 2015 Diagnostic Workup: Bethesda Criteria: Pathology Review All patients H&P All patients Biopsy All patients Colonoscopy All patients CEA All Patients Chest/Abdominal/Pelvic
More informationDoctor Discussion Guide
Talking to your healthcare provider about LONSURF (trifluridine and tipiracil) tablets If you have colon or rectal cancer that has spread to other parts of your body and have previously been treated with
More informationColorectal Cancer. Trusted Information to Help Manage Your Care from the American Society of Clinical Oncology
Colorectal Cancer Trusted Information to Help Manage Your Care from the American Society of Clinical Oncology ABOUT ASCO Founded in 1964, the American Society of Clinical Oncology, Inc. (ASCO ) is committed
More informationMedicinae Doctoris. One university. Many futures.
Medicinae Doctoris The Before and The After: Can chemotherapy revise the trajectory of gastric and esophageal cancers? Dr. David Dawe MD, FRCPC Medical Oncologist Assistant Professor Disclosures None All
More informationColon Cancer Update Christie J. Hilton, DO
POMA Winter Conference Christie Hilton DO Medical Oncology January 2018 None Colon Cancer Numbers Screening (brief update) Practice changing updates in colon cancer MSI Testing Immunotherapy in Colon Cancer
More informationCOLORECTAL CANCER FAISALGHANISIDDIQUI MBBS; FCPS; PGDIP-BIOETHICS; MCPS-HPE
COLORECTAL CANCER FAISALGHANISIDDIQUI MBBS; FCPS; PGDIP-BIOETHICS; MCPS-HPE PROFESSOR OF SURGERY & DIRECTOR, PROFESSIONAL DEVELOPMENT CENTRE J I N N A H S I N D H M E D I C A L U N I V E R S I T Y faisal.siddiqui@jsmu.edu.pk
More informationImaging techniques in the diagnosis, staging and follow up of GI cancers. Moderators: Banke Agarwal, MD and Paul Schultz, MD
Imaging techniques in the diagnosis, staging and follow up of GI cancers Moderators: Banke Agarwal, MD and Paul Schultz, MD Panelists Axel Grothey, MD Professor of Oncology Division of Medical Oncology
More informationColorectal Cancer. Mark Chapman. MA MS FRCS EBSQ(coloproct) 21 st March 2018 Consultant Coloproctologist
Colorectal Cancer Mark Chapman MA MS FRCS EBSQ(coloproct) 21 st March 2018 Consultant Coloproctologist Overview Epidemiology of colorectal cancer Adenoma carcinoma sequence Tumour diagnosis & staging Treatment
More informationNatural History and Epidemiology of Colorectal Cancer
Natural History and Epidemiology of Colorectal Cancer Prevent Cancer Foundation 2017 Dialogue for Action April 19, 2017 Roy J. Duhé, Ph.D. Associate Director for Cancer Education; Professor of Pharmacology;
More informationMicrosatellite instability and other molecular markers: how useful are they?
Microsatellite instability and other molecular markers: how useful are they? Pr Frédéric Bibeau, MD, PhD Head, Pathology department CHU de Caen, Normandy University, France ESMO preceptorship, Barcelona,
More informationRecognizing Available Therapies and Treatment Differences Within Classes in Colorectal Cancer
Recognizing Available Therapies and Treatment Differences Within Classes in Colorectal Cancer David Bai, 2018 PharmD Candidate, and Michael R. Page, PharmD, RPh COLORECTAL CANCERS INCLUDE CANCERS of both
More informationTrends and Comparative Effectiveness in Treatment of Stage IV Colorectal Adenocarcinoma
Trends and Comparative Effectiveness in Treatment of Stage IV Colorectal Adenocarcinoma Taylor S. Riall, MD, PhD CERCIT Workshop October 19, 2012 Department of Surgery Center for Comparative Effectiveness
More informationClinical Colon Cancer Abby Siegel MD COLON CANCER. 1. Epidemiology 2. Risk factors 3. Manifestations 4. Treatment
Clinical Colon Cancer 2008 Abby Siegel MD COLON CANCER 1. Epidemiology 2. Risk factors 3. Manifestations 4. Treatment 1 1. EPIDEMIOLOGY - Colorectal cancer is the third most common cancer in the United
More informationA916: rectum: adenocarcinoma
General facts of colorectal cancer The colon has cecum, ascending, transverse, descending and sigmoid colon sections. Cancer can start in any of the r sections or in the rectum. The wall of each of these
More informationIndex. Note: Page numbers of article titles are in boldface type.
Index Note: Page numbers of article titles are in boldface type. A Adaptive therapy, for locally advanced gastroesophageal cancers, 447 Adenocarcinoma, emerging novel therapeutic agents for gastroesophageal
More informationHeavilyTreated mcrc..whats next?
ESMO Preceptorship Programme Gastrointestinal Cancer 20-22 October 2016,Singapore Dr Surendra Pal Chaudhary Dept of Medical Oncology Dr BR Ambedkar Instituite Rotary Cancer Hospital All India Institute
More informationStrategy for the treatment of metastatic CRC through the lines
Strategy for the treatment of metastatic CRC through the lines I Congresso de Oncologia D Or 2013: Satellite Symposium, ROCHE David Cosgrove, MD Johns Hopkins University Disclosures No relevant financial
More informationThe following slides are provided as presented by the author during the live educa7onal ac7vity and are intended for reference purposes only.
The following slides are provided as presented by the author during the live educa7onal ac7vity and are intended for reference purposes only. If you have any ques7ons, please contact Imedex via email at:
More informationDisclosures. GI Cancers for the Boards. Esophageal Cancer. Esophageal Cancer: Risk Factors
Disclosures GI Cancers for the Boards Peter C. Enzinger, MD Dana-Farber Cancer Institute Major GI Malignancies: Esophageal Cancer Gastric Cancer Pancreatic Cancer Colorectal Cancer Less Common GI Malignancies:
More informationA superficial radiotherapy B single pass curettage C excision with 2 mm margins D excision with 5 mm margins E Mohs micrographic surgery.
1- A 63-year-old woman presents with a non-healing lesion on her right temple that has been present for over two years. On examination there is a 6 mm well defined lesion with central ulceration, telangiectasia
More informationMedical Therapy of Colorectal Cancer in the Biomarker Era
Medical Therapy of Colorectal Cancer in the Biomarker Era Axel Grothey Professor of Oncology Mayo Clinic College of Medicine Rochester, Minnesota Disclosures Consulting activities (honoraria went to the
More informationAdjuvant/neoadjuvant systemic treatment of colorectal cancer
5th ESO-ESMO Eastern Europe and Balkan Region Masterclass in Medical Oncology Belgrade, June 19 th 2018 Adjuvant/neoadjuvant systemic treatment of colorectal cancer Carlotta Antoniotti Polo Oncologico
More informationColorectal Pathway Board (Clinical Subgroup): Imaging Guidelines September 2015
Colorectal Pathway Board (Clinical Subgroup): Imaging Guidelines September 2015 1 Contents Page No. 1. Objective 3 2. Imaging Techniques 3 3. Staging of Colorectal Cancer 5 4. Radiological Reporting 6
More informationCase Conference. Craig Morgenthal Department of Surgery Long Island College Hospital
Case Conference Craig Morgenthal Department of Surgery Long Island College Hospital Neoadjuvant versus Adjuvant Radiation Therapy in Rectal Carcinoma Epidemiology American Cancer Society statistics for
More informationResident Seminar Aug 19 th, 2015 Colon: Neoplastic. Scott Rieder Dr. Colquhoun
Resident Seminar Aug 19 th, 2015 Colon: Neoplastic Scott Rieder Dr. Colquhoun Objectives Medical Expert: 1. The biologic basis of colon neoplasia 2. Colon cancer screening (guidelines and evidence) 3.
More informationNEOADJUVANT THERAPY IN CARCINOMA STOMACH. Dr Jyotirup Goswami Consultant Radiation Oncologist Narayana Superspeciality Hospital, Howrah
NEOADJUVANT THERAPY IN CARCINOMA STOMACH Dr Jyotirup Goswami Consultant Radiation Oncologist Narayana Superspeciality Hospital, Howrah NEOADJUVANT THERAPY?! Few believers Limited evidence Many surgeons
More informationPreoperative Data Colorectal Cancer Database
Preoperative Data Please place patient label here Patient Information Patient s Last Name First Middle Initial UR MH MP Birth Date Sex Post Code / / M F ECOG (see codes below) Date of Diagnosis Consultant
More informationRectal Cancer. GI Practice Guideline
Rectal Cancer GI Practice Guideline Dr. Brian Dingle MSc, MD, FRCPC Dr. Francisco Perera MD, FRCPC (Radiation Oncologist) Dr. Jay Engel MD, FRCPC (Surgical Oncologist) Approval Date: 2006 This guideline
More informationΚίκα Πλοιαρχοπούλου. Παθολόγος Ογκολόγος Ευρωκλινική Αθηνών
Κίκα Πλοιαρχοπούλου Παθολόγος Ογκολόγος Ευρωκλινική Αθηνών Time (months) Survival outcomes in mcrc have progressively improved over the past two decades Treatment options for many patients Multidisciplinary
More informationFollow this and additional works at: Part of the Neoplasms Commons
Philadelphia College of Osteopathic Medicine DigitalCommons@PCOM PCOM Physician Assistant Studies Student Scholarship Student Dissertations, Theses and Papers 2015 Will the Addition of Oxaliplatin to 5-Fluorouracil
More informationGI Tumor Board 3/8/2018. Case #1 IDEA. Case #1 Question #1 What is the next step in management?
GI Tumor Board Edward Kim George Poultsides Naseem Esteghamat Kenzo Hirose May Cho Alan Venook Arta Monjazeb Margaret Tempero George Fisher Andrew Ko Daniel Chang Thomas Semrad Sisi Haraldsdottir Case
More informationUpdates and best practices in the management of gastric cancer
Updates and best practices in the management of gastric cancer Olatunji B. Alese, MD Gastrointestinal Oncology, Winship Cancer Institute of Emory University July 28, 2017 1 Incidence 3rd leading cause
More informationAJCC 7 th Edition Staging Disease Site Webinar Colorectum
AJCC 7 th Edition Staging Disease Site Webinar Colorectum Donna M. Gress, RHIT, CTR Validating science. Improving patient care. This presentation was supported by the Cooperative Agreement Number DP13-1310
More information7 th Edition Staging. AJCC 7 th Edition Staging. Disease Site Webinar. Colorectum. Overview. This webinar is sponsored by
AJCC 7 th Edition Staging Colorectum Donna M. Gress, RHIT, CTR Validating science. Improving patient care. This presentation was supported by the Cooperative Agreement Number DP13-1310 from The Centers
More informationImmunotherapy in Colorectal cancer
Immunotherapy in Colorectal cancer Ahmed Zakari, MD Associate Professor University of Central Florida, College of Medicine Medical Director, Gastro Intestinal Cancer Program Florida Hospital Cancer Institute
More informationObjectives. Definitions. Colorectal Cancer Screening 5/8/2018. Payam Afshar, MS, MD Kaiser Permanente, San Diego. Colorectal cancer background
Colorectal Cancer Screening Payam Afshar, MS, MD Kaiser Permanente, San Diego Objectives Colorectal cancer background Colorectal cancer screening populations Colorectal cancer screening modalities Colonoscopy
More informationMedicina Personalizada de Precisión en el Abordaje del Cáncer Gástrico. Dra Desamparados Roda Pérez Hospital Clínico de Valencia Incliva, CIBERONC
Medicina Personalizada de Precisión en el Abordaje del Cáncer Gástrico Dra Desamparados Roda Pérez Hospital Clínico de Valencia Incliva, CIBERONC Gastric cancer Epidemiology Gastric cancer is an important
More informationColorectal Cancer Structured Pathology Reporting Proforma DD MM YYYY
Colorectal Cancer Structured Pathology Reporting Proforma Mandatory questions (i.e. protocol standards) are in bold (e.g. S1.03). Family name Given name(s) Date of birth DD MM YYYY S1.02 Clinical details
More informationEsophageal and GEJ Cancers. Case Presentations
Esophageal and GEJ Cancers Case Presentations Locally Advanced GEJ Cancer (Case 1) A 55 year old man with longstanding GERD presents with increasing solid food dysphagia. EGD reveals a 3 cm mass in the
More informationThe table below presents the summary of observed geographic variation for incidence and survival by type of cancer and gender.
Results and Maps Overview When disparities in cancer incidence and survival are evident, there are a number of potential explanations, including but not restricted to differences in environmental risk
More informationCase Scenario year-old white male presented to personal physician with dyspepsia with reflux.
Case Scenario 1 57-year-old white male presented to personal physician with dyspepsia with reflux. 7/12 EGD: In the gastroesophageal junction we found an exophytic tumor. The tumor occupies approximately
More informationOncological Treatment of Colorectal & Anal Cancer
Oncological Treatment of Colorectal & Anal Cancer Pathway of Care Kent & Medway Cancer Collaborative Publication date July 2018 Expected review date July 2019 Version number 10.0 Version status Final Table
More informationDiagnosed with Metastatic Colorectal Cancer?
ESSENTIALS Metastatic Colorectal Cancer Diagnosed with Metastatic Colorectal Cancer? It can be frightening to learn you or a loved one has been diagnosed with metastatic colorectal cancer. It is important
More informationDevelopment of Carcinoma Pathways
The Construction of Genetic Pathway to Colorectal Cancer Moriah Wright, MD Clinical Fellow in Colorectal Surgery Creighton University School of Medicine Management of Colon and Diseases February 23, 2019
More informationUnresectable or boarderline resectable disease
ESMO Preceptorship Colorectal Cancer Nov 2016 Barcelona Unresectable or boarderline resectable disease Claus-Henning Köhne Klinik für Onkologie und Hämatologie North West German Cancer Center (NWTZ) Learning
More informationThe Barcelona Colorectal Cancer Observatory
The Barcelona Colorectal Cancer Observatory The only relevant test of the validity of a hypothesis is comparison of prediction with experience. Milton Friedman 2011-2012 Predictions Growth of adjuvant
More informationOncology General Principles L A U R I E S I M A R D B R E A S T S U R G I C A L O N C O L O G Y F E L L O W D E C E M B E R
Oncology General Principles L A U R I E S I M A R D B R E A S T S U R G I C A L O N C O L O G Y F E L L O W D E C E M B E R 2 0 1 2 Objectives Discuss Diagnostic and staging strategies in oncology Know
More informationCancer Prevention & Control in Adolescent & Young Adult Survivors
+ Cancer Prevention & Control in Adolescent & Young Adult Survivors NCPF Workshop July 15-16, 2013 Patricia A. Ganz, MD UCLA Schools of Medicine & Public Health Jonsson Comprehensive Cancer Center + Overview
More informationIndex. Note: Page numbers of article titles are in boldface type.
Note: Page numbers of article titles are in boldface type. A Abdominoperineal excision, of rectal cancer, 93 111 current controversies in, 106 109 extent of perineal dissection and removal of pelvic floor,
More information