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1 General and Oral Pathology Topic Outlines

2 Are you ready? Are you Ready? ARE YOU READY? TO LEARN AND EXPERIENCE real ORAL BIOLOGY??? BOOTCAMP STYLE

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4 Going Beyond the Textbook with OBBC See the Light at the End of the Tunnel! 4

5 General Pathology: Part 1: INFLAMMATION Innate Defenses to Microbiota, Inflammation: Cytokines, Negative/Positives, Relationship Common Disorders Hematopoietic stem cells (HSCs): Monocyte/Macrophage; Pattern Recognition Receptors: M1/M2 Biochemical Mediators: Toll-Like Receptors (TLRs)/Nod-Like Receptors (NLRs): Pathogen-Associated Molecular Patterns of Molecules (PAMPs) and Danger-Associated Molecular Patterns (DAMPs); Specialized Proresolving Lipid Mediators (SPMs), C-Reactive Protein (CRP) Anti-Inflammatory Diet/Nutrition: General Concerns/Periodontal Disease

6 General Pathology: Part 2: IMMUNITY (continued) Primary: Red/Yellow Bone Marrow, Thymus Gland; Secondary Lymphoid Organs (SLOs): Lymph Nodes with Fibroblastic Reticular Cells (FRCs)/Dendritic Cells (DCs), Mucosa-Associated Lymphoid Tissue (MALT); Tertiary Lymphoid Organs (TLOs) B-Cell Types: Follicular (FO) with Plasma Cell, Memory with Cell Receptor (BCR), Regulatory Natural Killer (NK) Cell and Major Histocompatibility Complex (MHC)

7 General Pathology: Part 2: IMMUNITY T-Cell Types: T Helper (Th), Memory, Natural Killer (NKT), Suppressor Lymphocytes and Periodontal Disease Mast Cell Activation Syndrome (MCAS): Comparison Type 1 Hypersensitivity, Histamine, Mast Cells (MCs), Disorders, Associated Inflammatory Diseases, Dysautonomia, Kounis Syndrome (KS), Dental Treatment/Periodontal Disease

8 Oral Pathology (continued) Normal History - ask, observation, palpation Differential diagnostic categories Sizes, location and shapes of lesions Identify Oral Cancer Screening Adjunctive diagnostic aids Biopsy and cytology White Patches Features - leukodema, infectious etiology, candidiasis, trauma, cheilitis, substance keratosis, leukoplakia, Oral Cancer Epidemiology, risks Lichen Planus Red Patches Features candidiasis, mucositis, erythema, infectious diseases, cheilitis, erythroplakia

9 Oral Pathology (continued) Ulcerative Lesions Various types: necrotizing sialometaplasia, basal cell carcinoma, syphilis Multiple Ulcers/sloughing epithelium chronic aphthous Behcet syndrome Viral diseases Erythema Multiforme BMMP Single or Multiple Nodules/Swellings Fibroma Pyogenic granuloma HPV types, common oral lesions Verruca vulgaris Neurofibromas Drug induced oral lesions

10 Oral Pathology (continued) Salivary Gland Neoplasia Pleomorphic adenoma Malignant salivary gland disease Pigmented Lesions Melanosis Syndromes with pigmentation Pathology of the Bone Metastatic tumors Bisphosphonates Osteonecrosis of the jaw MRONJ and BRONJ

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