1. Challenging cases of eosinophilia (peripheral, bone marrow, or lymph node/tissue-based) falling into any of the following categories

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1 Society for Hematopathology/European Association for Haematopathology 2019 Workshop Addressing the Challenges of Eosinophilia and Mastocytosis September 12-14, 2019, Phoenix, AZ Case Submission Information - see process at bottom of this page Program Committee Mayo Clinic, Scottsdale, AZ Fiona E. Craig, MD Lisa M. Rimsza, MD Mayo Clinic, Rochester, MN Rebecca L. King, MD Kaaren K. Reichard, MD Kathleen A. Meyers, BS Workshop Review Panel Fiona E. Craig, MD Tracy I. George, MD Hans Peter Horny, MD Katalin Kelemen, MD, PhD Rebecca L. King, MD Attilio Orazi, MD Leticia Quintanilla-Fend, MD Kaaren K. Reichard, MD Sa A. Wang, MD Cases to be requested include: 1. Challenging cases of eosinophilia (peripheral, bone marrow, or lymph node/tissue-based) falling into any of the following categories Reactive disorders associated with eosinophilia mimicking chronic eosinophilic leukemia, including but not limited to: o Drug, toxin, infectious, other hypersensitivity Eosinophilia associated with non-myeloid, tissue-based neoplasms or non-neoplastic lymphoproliferations (Kimura disease, B and T cell lymphomas, Hodgkin lymphoma, histiocytic neoplasms, non-hematologic malignancy) Lymphocytic variant of hypereosinophilic syndrome (LV-HES) including challenging, nodal and tissue based T cell infiltrates Idiopathic hypereosinophilic syndrome Chronic eosinophilic leukemia, NOS

2 Genetic aberrations associated with eosinophilia including but not limited to: o Myeloid/lymphoid neoplasms associated with eosinophilia and PDGRFA, PDGFRB, FGFR1, and PCM1-JAK2 o AML with inversion 16 Eosinophilia associated with other diseases aside from mastocytosis or those listed above (e.g., AML, ALL with t(5;14), myeloproliferative neoplasms, myelodysplastic syndrome, etc.) 2. Challenging cases of mastocytosis (with or without eosinophilia) including: Cutaneous mastocytosis Systemic mastocytosis (including tissue- based and nodal mast cell infiltrates) o Indolent systemic mastocytosis o Smoldering systemic mastocytosis o Systemic mastocytosis with associated hematological neoplasm o Aggressive systemic mastocytosis o Mast cell leukemia including chronic and aleukemic examples o Mast cell sarcoma Myelomastocytic leukemia Entities with proliferations of cells that may mimic mast cells (including but not limited to acute promyelocytic leukemia, basophilic leukemia) Case requirements: 1. Online submission form 2. Powerpoint file with images 3. Glass slides including completed mailing form. Materials to send*: 1) 10 H&E and 10 unstained on any tissue and bone marrow core biopsies 2) Unstained bone marrow aspirate and/or peripheral blood smear, as available (preferred) (optional) 3) If unstained BMA and PBS are not available, stained slide(s) could be submitted *Material will NOT be returned. Address for sending slides: Attn: Kathleen Meyers Mayo Clinic Department of Hematopathology RO_HI_08_ st St SW Rochester, Minnesota Case Submission Categories: 1. Chronic eosinophilic leukemia and idiopathic hypereosinophilic syndrome

3 2. Myeloid/lymphoid neoplasms with eosinophilia and recurrent genetic abnormalities (WHO 2017) 3. Myeloid neoplasms associated with eosinophilia (eg, MPN, MDS, AML, ALL; excluding those discussed above) 4. Reactive eosinophilia mimicking chronic eosinophilic leukemia 5. T-cell lymphoproliferations associated with eosinophilia (eg, lymphocytic variant of hypereosinophilic syndrome) 6. Reactive eosinophil proliferations in tissue (Kimura, lymphomas, non-heme malignancy, Langerhans cell histiocytosis etc.) 7. Systemic mastocytosis and entities that mimic mastocytosis 8. Cutaneous and other tissue-based mastocytosis/mast cell lesions Deadline for Submission: February 1, 2019 Online Case Submission Two-Step Process ASCP is managing the online case submission process for SH using a custom content submission portal into the ASCPedia pathology assets archive. Follow the rest of this step-bystep guide to create your ASCP account and upload your case. All content from SH members is accessible only by SH Program Faculty and ASCP Staff. 1. All case contributors must have an SH/ASCP account at see instructions page 3. For secure access to the ASCPedia, anyone who submits a case for the SH 2019 Workshop must have a ASCP account (not ASCP membership, just a free online account). Current SH members already have an ASCP account, as they now manage their SH membership through ASCP. New contributors who are not SH members must create an SH/ASCP account, a simple process that captures your preferred address and creates a username and password. 2. After you have created or verified your SH/ASCP account, use this link to access the SH case contribution page inside the ASCPedia see instructions page You will be asked to authenticate by entering your ASH/ASCP account username and password (see item #1), then you will be placed directly onto the SH contribute page. Fill out all required information. You cannot save a draft and edit later, so be certain to complete your submission. Keep your textual detail in a separate Word document to save for mailing and as a back-up so that you do not lose your information.

4 Questions or problems with case submission? Contact SH Workshop Manager Melissa Lord-Toof,MBA, Manager of Affiliated Organizations at or by telephone at USA

5 Creating an ASCP.org Account Step 1: Go to and click on Login

6 Creating an ASCP.org Account Step 2: Click on Create an account

7 Creating an ASCP.org Account Step 3: Fill in all required Personal information and click Continue.

8 Creating an ASCP.org Account Step 4: Fill in all required Login information and click Continue.

9 Creating an ASCP.org Account Step 5: Fill in all required Contact information and click Continue.

10 Creating an ASCP.org Account Step 6: Fill in all required Demographic information and click Continue.

11 After you have created or verified your SH/ASCP account, use this link below to access the SH case contribution page inside the ASCPedia. You will be asked to authenticate by entering your ASCP account username and password, then you will be placed directly onto the SH contribute page. SH 2019 Workshop Online Case Submission Screenshots 11

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14 Questions or problems with case submission? Contact SH Workshop Manager Melissa Lord-Toof,MBA, Manager of Affiliated Organizations at or by telephone at USA 14