Hematology Page 1 of 8

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1 Hematology Page 1 of 8 Hematology Major Category Code Headings Revised 12/17 1 Basic methodology and test armamentarium Normal hematopoiesis & hemostasis RBC disorders, non-neoplastic WBC disorders, non-neoplastic Benign hematopoietic disorders with abnormalities in more than one lineage Infectious disorders expressed in the peripheral blood Benign disorders involving bone marrow not otherwise classifiable Benign disorders of lymphoid tissues Fluid specimens, non-neoplastic Immunodeficiency disorders Hemostasis and Thrombosis Myeloid neoplasms Acute leukemias of ambiguous lineage Lymphoid neoplasms Plasma cell neoplasms, paraprotein disorders & amyloidosis Histiocytic/dendritic cell neoplasms Metastatic neoplasms Administration/Laboratory management Professionalism, practice-based learning and improvement, interpersonal and 19 communication skills, systems-based practice 21140

2 Hematology Page 2 of 8 Hematology 1 Basic methodology and test armamentarium A General hematology testing & instrumentation General RBC analysis WBC analysis Platelet analysis B Hemoglobinopathy analysis Alkaline & acid electrophoresis HPLC Capillary electrophoresis Isoelectric focusing Other Hemoglobinopathy analysis C Morphologic methods Staining of PB/aspirate smears & tissue sections a Romanovsky type stains b Cytochemical and special hematology stains c Routine and special histologic stains Peripheral blood review Fluid review Bone marrow review Other Morphologic tissue review D Hemostasis and Thrombosis testing Sample collection and processing Coagulation and Fibrinolysis testing Platelet testing (including von Willebrand disease) Thrombophilia testing Other Hemostasis and Thrombosis testing E Immunohistochemistry Basic methods Pitfalls F Flow cytometry Basic methodology PNH & other non-neoplastic disease testing Lymphoid testing Myeloid testing Other Flow cytometry G Cytogenetic testing Classical FISH Other Cytogenetic testing (acgh, SNP) H Molecular testing Clonality/lineage Translocations/mutations Other Molecular testing (eg, gene expression array) 20083

3 Hematology Page 3 of 8 4 Coagulation-related I Other Basic methodology and tests Normal hematopoiesis & hemostasis A RBC B WBC Myeloid a Granulocyte b Monocyte/dendritic cells c Eosinophils/basophils/mast cells d Other Myeloid Lymphoid a B-cell b T-cell c NK cells d Other Lymphoid C Plasma cells D Normal Hemostasis and Thrombosis Platelets and Megakaryocytes Coagulation and Fibrinolysis E General hematopoiesis F Pediatric related issues including fetal hematopoiesis G Peripheral blood H Bone marrow I Lymph node J Spleen K. Thymus L. Other lymphoid tissue RBC disorders, non-neoplastic A Anemias Iron deficiency and related Sideroblastic anemias a Inherited b Acquired RBC membrane disorders a Hereditary spherocytosis b Hereditary elliptocytosis c Other RBC membrane disorders (e.g. spur cell) RBC enzyme disorders a G6PD b Pyruvate kinase deficiency c Other RBC enzyme disorders Other hemolytic anemias a Immune b Non-immune (e.g. thermal injury) Megaloblastic anemias 20366

4 Hematology Page 4 of 8 7 Aplastic anemias (RBC or all cell lineages) Anemia related to chronic disease & other disorders Congenital dyserythropoietic anemia Hemoglobinopathies a Hb S related disorders b Hb C disorders c Hb E disorders d Other Hemoglobinopathies Thalassemias, alpha and beta PNH Porphyrias Other Anemias B Erythrocytosis C Cold agglutinin disease D Abnormal red cell morphology, NOS WBC disorders, non-neoplastic A Inherited disorders with morphologic correlates Alder-Reilly anomaly Pelger-Huet anomaly Chediak-Higashi syndrome B Neutrophils quantitative & qualitative C Monocytes - quantitative and qualitative D Histiocytic disorders Storage disorders Macrophage activation disorders/hemophagocytic syndrome Other Histiocytic disorders E Dendritic disorders F Lymphocytes quantitative G Lymphocytes other H Eosinophils & basophils I Plasma cells Benign hematopoietic disorders with abnormalities in more than one lineage A Inherited disorders (including May-Hegglin anomaly) B Other Benign hematopoietic disorders Infectious disorders expressed in the peripheral blood A RBC/plasma infections Malaria Babesia Other RBC/plasma infections B WBC infections Anaplasma/Ehrlichia Other WBC infections (e.g. fungi, infectious mononucleosis) Benign disorders involving bone marrow not otherwise classifiable A Therapy related effects B Infectious disorders 20570

5 Hematology Page 5 of 8 1 Parvovirus C Bone abnormalities Paget disease Renal osteodystrophy Other Bone abnormalities D Other Benign Disorders of Bone Marrow Benign disorders of lymphoid tissues A Lymph node Cat scratch disease Toxoplasmosis Other infectious disorders Kikuchi-Fujimoto disease (histiocytic necrotizing 4 lymphadenitis) Rosai-Dorfman disease Castleman disease Dermatopathic lymphadenopathy Autoimmune disorders Non-lymphoid inclusions (e.g. mesothelial) Infectious mononucleosis Syphilis Drug-related (eg, phenytoin) Other Lymph node B Spleen Lymphoid hyperplasias Splenic cysts & other non-hematopoietic proliferations (eg, 2 hamartomas) Other Spleen C Thymus Thymic hyperplasia Other Thymus (e.g. thymoma) D Extranodal Fluid specimens, non-neoplastic A CSF B Other body fluids including semen analysis Immunodeficiency disorders A Primary B Secondary Viral-associated Iatrogenic C Immunodeficiency-associated lymphoproliferative disorders HIV-associated PTLD Other iatrogenic lymphoproliferative disorders Hemostasis and Thrombosis A Coagulation -and Fibrinolytic Disorders 20740

6 Hematology Page 6 of 8 1 Factor deficiencies or functional abnormalities Factor inhibitors Fibrinolysis B Platelet disorders and von Willebrand Disease Qualitative, normal platelet count Thrombocytosis Thrombocytopenia a Inherited b Immune c Other Thrombocytopenia von Willebrand Disease Abnormal platelet morphology, NOS C Thrombophilic disorders Laboratory diagnosis of thrombosis and thrombophilia Fibrinolytic thrombotic disorders Heparin induced thrombocytopenia Antiphospholipid antibody syndrome TTP/HUS DIC D Antiplatelet and anticoagulant drugs Warfarin and warfarin monitoring Heparin and heparinoid monitoring Direct thrombin and Factor Xa inhibitor monitoring Antiplatelet agent monitoring Myeloid neoplasms A Myeloproliferative neoplasms CML (BCR-ABL1+) Poycythemia vera Primary myelofibrosis Esssential thrombocythemia Chronic eosinophilic leukemia, NOS Mastocytosis Other Myeloproliferative neoplasms B Myeloid & lymphoid neoplasms with eosinophilia & abnormalities of PDFGRA, PDGFRB or FGFR C Myelodysplastic/myeloproliferative neoplasms CMML Juvenile myelomonocytic leukemia Other MDS/MPN (including atyp CML, BCR-ABL1-) D Myelodysplastic syndromes E AML and related precursor neoplasms AML with recurrent genetic abnormalities a AML with t(8;21) b AML with inv(16) or t(16;16) c APL with t(15;17) 20834

7 Hematology Page 7 of 8 d AML with t(9;11) e Other AML with recurrent genetic abnormalities AML with myelodysplasia-related changes Therapy-related myeloid neoplasms AML, NOS a Acute monoblastic/monocytic leukemia b Acute erythroid leukemia c Acute megakaryoblastic leukemia d Other AML, NOS Myeloid sarcoma Myeloid proliferations related to Down syndrome Blastic plasmacytoid dendritic cell neoplasm Acute leukemias of ambiguous lineage Lymphoid neoplasms A B lymphoblastic leukemia/lymphoma B lymphoblastic leukemia/lymphoma, NOS B lymphoblastic leukemia/lymphoma, with recurrent genetic 2 abnormalities Other B lymphoblastic leukemia/lymphoma B T lymphoblastic leukemia/lymphoma C Mature B-cell neoplasms CLL/SLL SMZL HCL LPL MALT lymphoma Nodal MZL Follicular lymphoma Mantle cell lymphoma Diffuse large B-cell lymphoma including variants and subtypes a Not otherwise specified (NOS) b Other Diffuse large B-cell lymphoma Burkitt lymphoma Cutaneous B-cell lymphomas Other Mature B-cell neoplasms D Mature T- and NK-cell neoplasms T-cell PLL T-cell and NK-cell LGL Adult T-cell leukemia/lymphoma Extranodal NK/T-cell lymphoma, nasal type Enteropathy-associated T-cell lymphoma Hepatosplenic T-cell lymphoma Mycosis fungoides & Sézary Syndrome CD30+ cutaneous lymphoproliferative disorders 20918

8 Hematology Page 8 of 8 9 Other cutaneous T-cell lymphomas PTCL, NOS Angioimmunoblastic T-cell lymphoma Anaplastic large cell lymphoma (ALK+ and ALK-) Other Mature T- and NK-cell neoplasms E Hodgkin lymphoma Nodular lymphocyte predominant Classical Plasma cell neoplasms, paraprotein disorders & amyloidosis A Plasma cell myeloma B Heavy chain diseases C Cryoglobulinemia D POEMS E Amyloidosis F Other Plasma cell neoplasms Histiocytic/dendritic cell neoplasms A Langerhans cell histiocytosis/sarcoma B Other Histiocytic/dendritic cell neoplasms Metastatic neoplasms A Bone marrow B Lymph node C Other Metastatic neoplasms Administration/Laboratory management A Managing a laboratory B Rules and regulations C Laboratory inspections D QA/QC issues E Other Administration/Laboratory management Professionalism, practice-based learning and improvement, interpersonal and 19 communication skills, systems-based practice 21140