Inspired. by the Body.

Transcription

1 Inspired. by the Body. Powered. by Electricity. Energized. by Results.

2 Inspired. by the Body. Powered. by Electricity. Energized. by Results. INTRODUCING Procellera Procellera from Vomaris is the world s only microcurrent generating antimicrobial wound dressing. Used in multiple clinical wound care applications, Procellera provides sustained broad-spectrum antimicrobial 8 efficacy and an optimal environment for wound healing. 7 Vomaris Innovations, Inc. is an electroceutical company specializing in microcurrent generating solutions for the wound care market and beyond. Vomaris flagship FDA-cleared product, Procellera, is a powerful example of the company s ongoing mission to develop and deliver evidence-based, patient-focused and cost-effective solutions, backed by a commitment to quality and innovation for the improvement of lives.

3 Inspired by the Body Electricity is Essential to Healing The body naturally creates and uses electrical energy to promote healing. 1 Transepithelial Potential An electric potential exists across intact skin. 2-4 Microcurrents Wound ZINC Zinc SILVER Silver Procellera is the only antimicrobial wound dressing powered by Advanced Microcurrent Technology Electrical Field in Tissue When skin is wounded, a change in electric potential occurs. This stimulus is the earliest guidance signal to initiate cell migration and re-epithelialization, and is essential to wound healing. 5 Versatile Application Procellera is used for broad indications across acute and chronic wounds: Superficial and full-thickness wounds Surgical incisions Donor and/or recipient graft sites First and second degree burns Diabetic, pressure and venous insufficiency ulcers

4 Powered by Electricity Augmenting the Body s Natural Healing Process Procellera Wound Dressings are an entirely new generation of wound and incision care solutions. Advanced Microcurrent Technology Designed to mimic physiologic electric currents, Procellera s embedded microcell batteries generate microcurrents in the presence of a conductive medium 6 to harness the power of electricity to support the body s natural electrical healing process. 7 Schematic representation Generates physiologic levels of microcurrent (2-10µA) that are known to be necessary for healing 1 Flexible and portable with no need for external power source Conformable & Comfortable Conforms to wound for maximum mobility and comfort Easily cut to fit Available in a variety of configurations, including Procellera Helix composite dressings and Procellera Rx non-adhesive single-layer dressings Broad Spectrum Antimicrobial Efficacy Procellera s antimicrobial 8-10 protection creates an optimal environment for wound healing. 7 Provides effective and sustained antimicrobial efficacy 11 Kills a broad spectrum of harmful pathogens, including multi-drug resistant 8 and biofilm-forming bacteria, 9-10 to help reduce risk of infection No silver release into the bloodstream 6

5 Energized by Results Optimizing Outcomes Studies have shown Procellera to reduce the risk of infection 8-10 and promote the healing process 7 to optimize outcomes. Reduce Risk of Infection Effective, sustained broad-spectrum antimicrobial efficacy for up to seven days 11 Prevents bacterial growth 10 Electricidal antimicrobial efficacy vs. silver alone 10 Procellera Silver Only Live/dead fluorescence staining demonstrates bacterial killing of P. aeruginosa within Procellera compared to a standard silver-based dressing at 24 hours. Red = dead Green = alive Week 1 Post-op Promote Healing Improved scar appearance vs. standard dressings 13 Prospective case series; Skin graft harvest sites (N=13) Standard of Care Procellera 0 Hour 9 Hours Provide an Optimal Environment for Wound Healing Keratinocyte migration vs. silver observed at 9 hours, in-vitro scratch assay 7 Procellera 0 Hour 9 Hours Silver Only

6 vo mar is The company name is derived from nature s remarkable ability to generate electricity when voltage potential (vo) combines with a conductive medium like saline (mar, meaning the sea in Spanish). This creates the catalyst for its microcurrent generating technologies that are redefining the wound care market. References: 1 Nuccitelli R. A role for endogenous electric fields in wound healing. Curr Top Dev Biol 2003; 58: McCaig CD, Rajnicek AM, Song B et al. Controlling Cell Behavior Electrically: Current Views and Future Potential. Physiological Reviews 2005; 85(3): Foulds IS, Barker AT. Human skin battery potentials and their possible role in wound healing. British J of Dermatology 1983; 109: Vanable JW. Integumentary Potentials and Wound Healing. New York: Alan R. Liss, Inc.; pp Zhao M. Electrical fields in wound healing An overriding signal that directs cell migration. Semin Cell Dev Biol; 20(6): Park SS, Kim H, Makin IR, Skiba JB, Izadjoo MJ. Measurement of microelectric potentials for a bioelectrically-active wound care device in the presence of bacteria. J Wound Care 2015, 24(1): Banerjee J, Ghatak P, Roy S, Khanna S, Sequin EK, Bellman K, Dickinson BC, Suri P, Subramaniam V, Chang CJ, Sen CK. Improvement of human keratinocyte migration by a redox active bioelectric dressing. PLOS ONE 2014; 9(3):e Kim H, Makin I, Skiba J, Ho A, Housler G, Stojadinovic A, Izadjoo M. Antibacterial Efficacy Testing of a Bioelectric Wound Dressing Against Clinical Wound Pathogens. The Open Microbiology Journal 2014; 8: Kim H, Izadjoo MJ. Antibiofilm efficacy evaluation of a bioelectric dressing in mono- and multi-species biofilms. J Wound Care 2015; 24 Suppl 2:S10-4. bk Banerjee J, Ghatak PD, Roy S, Khanna S, Hemann C, Deng B, et al. (2015) Silver-Zinc Redox-Coupled Electroceutical Wound Dressing Disrupts Bacterial Biofilm. PLoS ONE 10(3): e doi: /journal.pone bl In-vitro data on file. bm Harding AC, Gil J, Valdes J, Solis M, Davis SC. Efficacy of a Novel Bioelectric Dressing in Healing Deep Partial-thickness Wounds in a Porcine Model. Ostomy Wound Manage 2012; 58(9): bn Blount AL, Foster S, Rapp DA, Wilcox R. The Use of Bioelectric Dressings in Skin Graft Harvest Sites: A Prospective Case Series. J Burn Care Res 2012;33(3): bo Whitcomb E, Monroe N, Hope- Higman J, Campbell P. Demonstration of a Microcurrent-Generating Wound Care Device for Wound Healing within a Rehabilitation Center Patient Population. J Am Coll Clin Wound Spec 2013; 4(2): Learn more about Procellera wound care with Advanced Microcurrent Technology at Procellera.com or contact a Vomaris representative at Vomaris Wound Care, Inc East Fifth Street, Tempe, AZ K-01/L Apr Vomaris. All rights reserved. Vomaris, Procellera, Procellera Helix, Procellera with logo, Advanced Microcurrrent Technology and Inspired by the body. Powered by electricity. Energized by results. are all trademarks of Vomaris Innovations, Inc. All other trademarks are the property of their respective owners.