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1 3rd edition comprehensive pharmacy review EDITORS, Ph.D., R.Ph., Pharm.D., R.Ph. Paul F. Souney, M.S., R.Ph., Pharm.D., R.Ph. Lawrence H. Block, Ph.D., R.Ph. Williams &: Wilkins A WAVERLY COMPANY BALTIMORE PHILADELPHIA LONDON PARIS BANGKOK BUENOS AIRES HONG KONG MUNICH SYDNEY TOKYO WROCLAW

2 Contents PART I: PHARMACEUTICAL SCIENCES 1. Drug Product Development in the Pharmaceutical Industry 1 Anton H. Amann, 2. Pharmaceutical Calculations and Statistics 9 James K. Drennen, III, Riccardo Boni 3. Pharmaceutical Principles and Drug Dosage Forms 28 Lawrence H. Block, Andrew B. C. Yu 4. Biopharmaceutics and Drug Delivery Systems 77 Lawrence H. Block, Charles C. Collins 5. Extemporaneous Prescription Compounding 90 Loyd V. Allen 6. Pharmacokinetics Bioavailability and Bioequivalence Organic Chemistry and Biochemistry 141 Edward F. La Sala, John D. Leary 9. Microbiology 154 Ralph N. Blomster 10. Immunology 165 Gail Coodman-Snitkoff, Vincent C. LoPresti 11. Biotechnological Products 199 Andrew B. C. Yu, Godwin W. Fong 1 2. Medicinal Chemistry and Drug Metabolism 210 Marc W. Harrold 13. Pharmacodynamics 246 \ Nelson S. Yee,

3 vi I 4. Drugs Affecting the Autonomic Nervous System and 255 the Neuromuscular Junction David C. Kosegarten, Edward F. LaSala 1 5. Drugs Affecting the Central Nervous System 270 David C. Kosegarten, Edward F. LaSala, Scott F. Long 1 6. Autocoids and Their Antagonists, Non-Narcotic Analgesic-Antipyretics 294 and Nonsteroidal Anti-Inflammatory Drugs David C. Kosegarten, Edward F. LaSala, Scott F. Long 1 7. Drugs Affecting the Cardiovascular System 307 David C. Kosegarten, Edward F. LaSala, J. Edward Moreton 18. Diuretics 326 David C. Kosegarten, Edward F. LaSala, J. Edward Moreton 1 9. Hormones and Related Drugs 333 Marc W. Harrold, Pui-Kai Li 20. Drug Interactions Nuclear Pharmacy 360 Stephen C. Dragotakes, Ronald J. Callahan PART II: PHARMACY PRACTICE 22. Pharmaceutical Care and the Scope of Pharmacy Practice 383 Peggy C. Yarborough 23. Drug Information Resources 393 Paul F. Souney, Connie Lee Barnes 24. Federal Pharmacy Law 403 Robert C. Pavlan, Jr. 25. Reviewing and Dispensing Prescriptions and Medication Orders 428 Todd A. Brown 26. Sterile Products 436 Ernest R. Anderson, Jr. "27. Parapharmaceuticals, Home Diagnostics, and Medical Devices 452 Todd A. Brown 28. Nonprescription Medication: An Overview 463

4 29. OTC Otic, Dental, and Ophthalmic Agents 471, Connie Lee Barnes, Constance A. McKenzie 30. OTC Agents for Pediculosis, Acne, Sun Protection, 488 and Contact Dermatitis 31. OTC Weight Control and Sleep Aids OTC Agents for Fever, Pain, Cough, Cold, and Allergic Rhinitis 518 Gerald E. Schumacher, 33. OTC Agents for Constipation, Diarrhea, Hemorrhoids, and Heartburn 536 Stephen H. Fuller,, Julianne B. Pinson 34. OTC Menstrual, Vaginal, and Contraceptive Agents 558 Constance A. McKenzie, 3 5. Clinical Toxicology 569 John J. Ponzillo 36. Therapeutic Drug Monitoring 584 Lyndon D. Braun 37. Drug Use in Special Patient Populations: Pediatric, Pregnant, Geriatric 598, H. William McGhee 38. Common Clinical Laboratory Tests 611, D. Byron May 39. Ischemic Heart Disease 630 Barbara Szymusiak-Mutnick 40. Cardiac Arrhythmias Systemic Hypertension Congestive Heart Failure Infectious Diseases 705 Paul F. Souney, Cheryl A. Stoukides 44. Seizure Disorders 750 Azita Razzaghi 45. Parkinson's Disease 769 Azita Razzaghi vii

5 Index 1018 viii 46. Schizophrenia Affective Disorders Asthma and Chronic Obstructive Pulmonary Disease 806 Laura Wilson, Mary Ann Dzurec 49. Rheumatoid Arthritis Hyperuricemia and Gout Peptic Ulcer Disease 850 Paul F. Souney, Cheryl Stoukides 52. Diabetes Mellitus Thyroid Disease " 882 John E. Janosik 54. Renal Failure 899 Andrew L. Wilson 55. Principles of Cancer Chemotherapy 915 Amy J. Becker 56. Pain 928 David R. Platt 57. Nutrition and the Hospitalized Patient 940 Robert A. Quercia, Kevin P. Keating 58. Immunosuppressive Agents in Organ Transplantation 954 David I. Min Appendix A: Prescription Dispensing Information and Metrology 961 Appendix B: Common Prescription Drugs and 969 Over-the-Counter Products Appendix C: Reference Charts Useful for Patient Counseling 979 Appendix D: State and National Pharmacy Organizations 1001 Appendix E: Budgeting for Drug Information Resources 1016

comprehensive pharmacy review

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