Once Daily Dosing for Induction and Maintenance of Remission in Ulcerative Colitis
|
|
- Dana Owens
- 5 years ago
- Views:
Transcription
1 Once Daily Dosing for Induction and Maintenance of Remission in Ulcerative Colitis John K. Marshall MD MSc FRCPC AGAF Division of Gastroenterology McMaster University JKM 2014
2 Svartz N. Acta Med Scand 1942;110:577
3 Treatment of Ulcerative Colitis Severe Moderate Mild Proximal Surgery Anti-TNFα Cyclosporine IV Steroids Infliximab, IV/PO Steroids 6MP/Azathioprine Aminosalicylates Topical Corticosteroids Aminosalicylates Oral Rectal Distal
4 Sulfasalazine: Dose-Dependent Efficacy and Toxicity Response Toxicity 1g 2g 3g 4g Das K. N Engl J Med 1973;289:491-4
5 Approved Induction Regimens for Oral 5ASA (Canada) Product: Asacol TM Mezavant TM Pentasa TM Salofalk TM Salazopyrin TM Dose Frequency: Divided Doses OD QID TID-QID BID-QID
6 Patient Adherence in Ulcerative Colitis % of Patients Adherent % 40% - 60% 40% 20 0 Clinical Trials Communitybased Trials Patients in Remission Kane SV. Aliment Pharmacol Ther 2006;23:577-85
7 Predictors of Non-Adherence to 5ASA in Ulcerative Colitis Kane SV. Aliment Pharmacol Ther 2010;32:1051-8
8 Reasons for Non-Compliance: CCFA Survey % of Respondents Internet survey: N=944 noncompliant UC patients 90% just forgot to take their medication Loftus EV. Inflamm Bowel Dis 2006;12:
9 Oral 5ASA for Induction of Remission of Ulcerative Colitis Literature search: MEDLINE, EMBASE, Cochrane Library from inception to 19/3/2014 Criteria for inclusion: Prospective, parallel-design RCT: Adult subjects Duration 4 weeks Oral 5ASA vs. placebo, sulfasalazine or other 5ASA Primary endpoint: Proportion who fail to enter complete global or clinical remission (as defined by study authors) by ITT analysis Feagan BG. Cochrane Database Syst Rev 2014a
10 Oral 5ASA for Induction of Remission of Ulcerative Colitis 51 eligible studies (N=8508) 15 5ASA vs. Placebo 17 5ASA vs. Sulfasalazine 12 5ASA vs. other 5ASA 10 5ASA dose ranging 4 trials comparing once-daily vs. conventional dosing: Kamm. Gastroenterology 2007;132:66-75 Lichtenstein. Clin Gastroenterol Hepatol 2007;5: Kruis. Gut 2009;58: Flourie. Aliment Pharmacol Ther 2013;37: Feagan BG. Cochrane Database Syst Rev 2014a
11 Once Daily vs. Conventional Dosing: Failure to Induce Clinical Remission Feagan BG. Cochrane Database Syst Rev 2014a
12 Oral 5ASA for Maintenance of Remission of Ulcerative Colitis Literature search: MEDLINE, EMBASE, Cochrane Library from inception to 19/3/2014 Criteria for inclusion: Prospective, parallel-design RCT: Adult subjects Duration months Oral 5ASA vs. placebo, sulfasalazine or other 5ASA Primary endpoint: Endoscopic or clinical relapse (as defined by study authors) by ITT analysis Feagan BG. Cochrane Database Syst Rev 2014b
13 Oral 5ASA for Maintenance of Remission of Ulcerative Colitis 39 eligible studies (N=7301) 7 trials of 5ASA vs. Placebo 12 trials of 5ASA vs. Sulfasalazine 5 trials of 5ASA vs. other 5ASA 8 trials of 5ASA dose ranging 10 trials comparing once-daily vs. conventional dosing: Kane. Clin Gastroenterol Hepatol 2003;1:170-3 Kamm. Gut 2008;57: Kane. Pat Pref Adherence 2008;2:253-8 Dignass. Clin Gastroenterol Hepatol 2009;7:762-9 Prantera. Aliment Pharmacol Ther 2009;30: Sandborn. Gastroenterology 2010;138: Hawthorne. Gastroenterology 2011;140:S65 Kruis. Aliment Pharmacol Ther 2011;33: D Haens. Am J Gastroenterol 2012;107: Wantanabe. Infamm Bowel Dis 2013; 19: Feagan BG. Cochrane Database Syst Rev 2014b
14 Once Daily vs. Conventional Dosing: Relapse at 12 Months Feagan BG. Cochrane Database Syst Rev 2014b
15 Once Daily vs. Conventional Dosing Failure to Adhere (Maintenance) Feagan BG. Cochrane Database Syst Rev 2014b
16 Once Daily vs. Conventional Dosing: Adverse Events (Maintenance) Feagan BG. Cochrane Database Syst Rev 2014b
17 Compliance* with Oral 5ASA: Retrospective Analysis of RAMQ 5 ASA Overall Lachaine J. BMC Gastroenterol 2013;13:23
18 5ASA Suppositories OD vs. TID for Active Ulcerative Proctitis (N=408, single-blind, 6 weeks) Andus T. Inflamm Bowel Dis 2010;16:
19 Summary 5ASA is effective for inducing and maintaining remission in mild to moderately active ulcerative colitis Adherence to therapy for mild to moderately active ulcerative colitis is sub-optimal Once daily dosing of oral 5ASA is as effective and safe as conventional divided dosing for inducing and maintaining remission of mild to moderately active ulcerative colitis Once daily dosing of oral 5ASA may improve adherence
20 Conclusions Oral 5ASA can be dosed once daily for inducing and maintaining remission of mild to moderately active ulcerative colitis This strategy appears to applicable to 5ASA therapy as a class, and not specific to any particular formulation
21 JKM 2014 THANK YOU
Oral mesalamine formulations are first-line treatments
COCHRANE REVIEW Once Daily Oral Mesalamine Compared to Conventional Dosing for Induction and Maintenance of Remission in Ulcerative Colitis: A Systematic Review and Meta-Analysis Brian G. Feagan, MD, and
More informationMonth/Year of Review: September 2012 Date of Last Review: September 2010
Copyright 2012 Oregon State University. All Rights Reserved Drug Use Research & Management Program Oregon State University, 500 Summer Street NE, E35, Salem, Oregon 97301-1079 Phone 503-947-5220 Fax 503-947-1119
More informationThe legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION. 20 October 2010
The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION 20 October 2010 MEZAVANT LP 1200 mg, prolonged-release gastro-resistant tablets B/60 (CIP code: 378 689-2) Applicant
More informationA Bad Outcome. Drugs don t work in patients who don t take them. Does Compliance Really Matter? Why Should I Care about This?
Does Compliance Really Matter? Sunanda Kane MD, MSPH, FACG, FACP, AGAF Professor of Medicine Mayo Clinic Drugs don t work in patients who don t take them C. Everett Koop A Bad Outcome Why Should I Care
More information5-aminosalicylic acid (5-ASA) is the mainstay of first-line therapy
MMX Mesalamine for Induction and Maintenance Therapy in Mild-to-Moderate Ulcerative Colitis Stephen B. Hanauer, MD 1 ; Gary R. Lichtenstein, MD 2 ; Michael A. Kamm, MD 3 ; William J. Sandborn, MD 4 ; Kirstin
More informationReview article: induction therapy for patients with active ulcerative colitis
Alimentary Pharmacology & Therapeutics Review article: induction therapy for patients with active ulcerative colitis S. P. L. TRAVIS John Radcliffe Hospital and Linacre College, Oxford, UK Correspondence
More informationEfficacy of 5-Aminosalicylates in Ulcerative Colitis: Systematic Review and Meta-Analysis
CLINICAL AND SYSTEMATIC S nature publishing group 601 Efficacy of 5-Aminosalicylates in Ulcerative Colitis: Systematic Review and Meta-Analysis Alexander C. Ford, MBChB, MD, MRCP 1, 2, Je an - Pau l Ach
More informationArticle: Min, T and Ford, AC (2016) Efficacy of mesalazine in IBS. Gut, 65 (1). pp ISSN
This is a repository copy of Efficacy of mesalazine in IBS. White Rose Research Online URL for this paper: http://eprints.whiterose.ac.uk/97338/ Version: Accepted Version Article: Min, T and Ford, AC (2016)
More information5-ASA Therapy, Steroids and Antibiotics in Inflammatory Bowel Disease
5-ASA Therapy, Steroids and Antibiotics in Inflammatory Bowel Disease David T. Rubin, MD Associate Professor of Medicine Co-Director, Inflammatory Bowel Disease Center University it of Chicago Medical
More informationUlcerative colitis (UC) is a chronic disease that is commonly
ORIGINAL ARTICLE Voting with Their Feet (VWF) Endpoint: A Meta-Analysis of an Alternative Endpoint in Clinical Trials, Using 5-ASA Induction Studies in Ulcerative Colitis Sujal C. Rangwalla, DO,* Akbar
More informationHow to Optimize Induction and Maintenance Responses: Definitions and Dosing Advances in Inflammatory Bowel Disease December 6, 2009
How to Optimize Induction and Maintenance Responses: Definitions and Dosing 2009 Advances in Inflammatory Bowel Disease December 6, 2009 Fernando Velayos MD MPH University of California, San Francisco
More information5-ASA for the treatment of Crohn s disease DR. STEPHEN HANAUER FEINBERG SCHOOL OF MEDICINE, NORTHWESTERN UNIVERSITY, CHICAGO, IL, USA
5-ASA for the treatment of Crohn s disease DR. STEPHEN HANAUER FEINBERG SCHOOL OF MEDICINE, NORTHWESTERN UNIVERSITY, CHICAGO, IL, USA Background RCTs investigating the efficacy of aminosalicylates for
More informationMild-moderate Ulcerative Colitis Sequential & Combined treatments need to be tested. Philippe Marteau, Paris, France
Mild-moderate Ulcerative Colitis Sequential & Combined treatments need to be tested Philippe Marteau, Paris, France Sequential vs combined treatments When should one switch? Sequential vs combined treatments
More informationMedical Management of Inflammatory Bowel Disease
Medical Management of Inflammatory Bowel Disease John K. Marshall MD MSc FRCPC AGAF Division of Gastroenterology McMaster University John K. Marshall: Conflicts of Interest Speaker: AbbVie, Allergan, Ferring,
More informationReview article: the long-term management of ulcerative colitis
Aliment Pharmacol Ther 2004; 20 (Suppl. 4): 97 101. Review article: the long-term management of ulcerative colitis S. B. HANAUER Section of Gastroenterology, University of Chicago, Chicago, IL, USA SUMMARY
More informationNew treatment options in UC. Rob Bryant IBD Consultant Royal Adelaide Hospital
New treatment options in UC Rob Bryant IBD Consultant Royal Adelaide Hospital Talk Outline 1. Raising expectations 2. Optimising UC therapy 3. Clinical trials 4. What s new on the PBS? 5. Questions 1.
More informationSeptember 12, 2015 Millie D. Long MD, MPH, FACG
Update on Biologic Therapy in 2015 September 12, 2015 Millie D. Long MD, MPH, FACG Assistant Professor of Medicine Inflammatory Bowel Disease Center University of North Carolina-Chapel Hill Outline Crohn
More informationBiologic Therapy for Ulcerative Colitis in 2015
5/6/215 Biologic Therapy for Ulcerative Colitis in 215 John K. Marshall MD MSc FRCPC AGAF Division of Gastroenterology McMaster University Bressler B, Marshall JK, et al. Gastroenterology 215;148: 135-58
More informationPosition of Biologics in IBD Circa 2006: Top Down vs. Step Up Therapy
Position of Biologics in IBD Circa 2006: Top Down vs. Step Up Therapy Stephen B. Hanauer, MD University of Chicago Potential Conflicts: Centocor/Schering, Abbott, UCB, Elan, Berlex, PDL Goals of Treatment
More informationTreatment Goals. Current Therapeutic Pyramids Crohn s Disease Ulcerative Colitis 11/14/10
Current Management of IBD: From Conventional Agents to Biologics Stephen B. Hanauer, M.D. University of Chicago Treatment Goals Induce and maintain response/ remission Prevent complications Improve quality
More informationTreatment of Ulcerative Colitis in the Elderly: A Systematic
Medicine Insights: Geriatrics Review Open Access Full open access to this and thousands of other papers at http://www.la-press.com. Treatment of Ulcerative Colitis in the Elderly: A Systematic Review Brooke
More informationRecent Advances in the Management of Refractory IBD
Recent Advances in the Management of Refractory IBD Raina Shivashankar, M.D. Assistant Professor of Medicine Division of Gastroenterology and Hepatology Thomas Jefferson University Philadelphia, PA Outline
More informationCCFA. Crohns Disease vs UC: What is the best treatment for me? November
CCFA Crohns Disease vs UC: What is the best treatment for me? November 8 2009 Ellen J. Scherl,, MD, FACP,AGAF Roberts Inflammatory Bowel Disease Center Weill Medical College Cornell University New York
More informationModerately to severely active ulcerative colitis
Adalimumab in the Treatment of Moderate-to-Severe Ulcerative Colitis: ULTRA 2 Trial Results Sandborn WJ, van Assche G, Reinisch W, et al. Adalimumab induces and maintains clinical remission in patients
More informationTopical therapy is underused in patients with ulcerative colitis
Journal of Crohn's and Colitis (2014) 8, 56 63 Available online at www.sciencedirect.com ScienceDirect Topical therapy is underused in patients with ulcerative colitis F. Seibold a, f,, N. Fournier b,
More informationIBD Understanding Your Medications. Thomas V. Aguirre, MD Santa Barbara GI Consultants
IBD Understanding Your Medications Thomas V. Aguirre, MD Santa Barbara GI Consultants IBD Understanding Your Medications (& Your Doctor) Thomas V. Aguirre, MD Santa Barbara GI Consultants Disclosure I
More informationOxford Inflammatory Bowel Disease MasterClass The mesalazine chamaeleon
Oxford Inflammatory Bowel Disease MasterClass The mesalazine chamaeleon Ailsa Hart Lead IBD Unit, St Mark s Hospital Senior Clinical lecturer Imperial College, London Oxford Inflammatory Bowel Disease
More informationBiologics in IBD. Brian P. Bosworth, MD, NYSGEF Associate Professor of Medicine Weill Cornell Medical College
Biologics in IBD Brian P. Bosworth, MD, NYSGEF Associate Professor of Medicine Weill Cornell Medical College Case 30 year old man diagnosed with ulcerative proctitis diagnosed in 2003 Had been maintained
More informationPositioning New Therapies
Positioning New Therapies Stephen Hanauer, MD Professor of Medicine Medical Director, Digestive Disease Center Northwestern Medicine Chicago, Illinois Speaker Disclosure Stephen Hanauer, MD has disclosed
More informationRandomised clinical trial: delayed-release oral mesalazine 4.8 g day vs. 2.4 g day in endoscopic mucosal healing ASCEND I and II combined analysis
Alimentary Pharmacology and Therapeutics Randomised clinical trial: delayed-release oral mesalazine 4.8 g day vs. 2.4 g day in endoscopic mucosal healing ASCEND I and II combined analysis G. R. Lichtenstein*,
More informationChoosing and Positioning Biologic Therapy for Crohn s Disease: (Still) Looking for the Crystal Ball
Choosing and Positioning Biologic Therapy for Crohn s Disease: (Still) Looking for the Crystal Ball Siddharth Singh, MD, MS Assistant Professor of Medicine Division of Gastroenterology Division of Biomedical
More informationTitle: Authors: Journal:
IMPORTANT COPYRIGHT NOTICE: This electronic article is provided to you by courtesy of Ferring Pharmaceuticals. The document is provided for personal usage only. Further reproduction and/or distribution
More informationFERRING PHARMACEUTICALS. Enjoy The simple COR/939/2014/CH3
Enjoy The simple pleasures of life COR/939/2014/CH3 Ulcerative colitis disrupts the simple pleasures in life Patients with ulcerative colitis may live with a considerable symptom burden despite medical
More informationClinical Course of Infliximab Treatment in Korean Pediatric Ulcerative Colitis Patients: A Single Center Experience
pissn: 2234-8646 eissn: 2234-8840 http://dx.doi.org/10.5223/pghn.2014.17.1.31 Pediatric Gastroenterology, Hepatology & Nutrition 2014 March 17(1):31-36 Original Article PGHN Clinical Course of Infliximab
More informationClinical Medicine Insights: Gastroenterology. Once-Daily MMX Mesalamine in the Management of Ulcerative Colitis
Clinical Medicine Insights: Gastroenterology Review Open Access Full open access to this and thousands of other papers at http://www.la-press.com. Once-Daily MMX Mesalamine in the Management of Ulcerative
More informationNew Perspectives on the Diagnosis and Management of IBD. Disclosures
New Perspectives on the Diagnosis and Management of IBD Joel R. Rosh, MD Director, Pediatric Gastroenterology Goryeb Children's Hospital/Atlantic Health Professor of Pediatrics Icahn School of Medicine
More informationOf Treatment For Inflammatory Bowel Diseases
Balancing The Risks And Benefits Of Treatment For Inflammatory Bowel Diseases Corey A. Siegel, MD Assistant Professor of Medicine Dartmouth Medical School Director, Inflammatory Bowel Diseases Center Dartmouth-Hitchcock
More informationEfficacy and Safety of Treatment for Pediatric IBD
Efficacy and Safety of Treatment for Pediatric IBD Andrew B. Grossman MD Co-Director, Center for Pediatric Inflammatory Bowel Disease Assistant Professor of Clinical Pediatrics Division of Gastroenterology,
More informationPerianal and Fistulizing Crohn s Disease: Tough Management Decisions. Jean-Paul Achkar, M.D. Kenneth Rainin Chair for IBD Research Cleveland Clinic
Perianal and Fistulizing Crohn s Disease: Tough Management Decisions Jean-Paul Achkar, M.D. Kenneth Rainin Chair for IBD Research Cleveland Clinic Talk Overview Background Assessment and Classification
More informationClinical trial: once-daily mesalamine granules for maintenance of remission of ulcerative colitis a 6-month placebo-controlled trial
Alimentary Pharmacology and Therapeutics Clinical trial: once-daily mesalamine granules for maintenance of remission of ulcerative colitis a 6-month placebo-controlled trial G. R. Lichtenstein*, G. L.
More informationTreatment of ulcerative colitis with adalimumab or infliximab: long-term follow-up of a single-centre cohort
Alimentary Pharmacology and Therapeutics Treatment of ulcerative colitis with adalimumab or infliximab: long-term follow-up of a single-centre cohort N. Gies, K. I. Kroeker, K. Wong & R. N. Fedorak Division
More informationUlcerative colitis (UC) is a chronic relapsing and remitting inflammatory
TREATMENT UPDATE The Efficacy of Oral 5-ASAs in the Treatment of Active Ulcerative Colitis: A Systematic Review Sunanda V. Kane, MD, MSPH,* David J. Bjorkman, MD, MSPH, SM (Epid) *University of Chicago,
More informationPositioning Biologics in Ulcerative Colitis
Positioning Biologics in Ulcerative Colitis Bruce E. Sands, MD, MS Acting Chief, Gastrointestinal Unit Massachusetts General Hospital Associate Professor of Medicine Harvard Medical School Sequential Therapies
More informationTo help protect your privacy, PowerPoint prevented this external picture from being automatically downloaded. To download and display this picture,
To help protect your privacy, PowerPoint prevented this external picture from being automatically downloaded. To download and display this picture, click Options in the Message Bar, and then click Enable
More informationEfficacy and Safety of Treatment for Pediatric IBD
Efficacy and Safety of Treatment for Pediatric IBD Andrew B. Grossman MD Co-Director, Center for Pediatric Inflammatory Bowel Disease Associate Professor of Clinical Pediatrics Division of Gastroenterology,
More informationEdward V. Loftus, Jr., M.D.
Edward V. Loftus, Jr., M.D. Professor of Medicine Faculty photo will be placed here loftus.edward@mayo.edu 2015 MFMER 3417200-1 Inflammatory Bowel Disease Therapy Edward V. Loftus, Jr., M.D. Gastroenterology
More informationEmerging g therapies for IBD: A practical approach to positioning. Sequential Therapies for IBD
Emerging g therapies for IBD: A practical approach to positioning Stephen B. Hanauer, MD Sequential Therapies for IBD Disease Severity at Presentation Severe Anti-TNF +/IS Cyclosporine (UC) Colectomy (UC)
More informationUlcerative colitis (UC) is a relatively common inflammatory
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY 2012;10:513 519 Efficacy of Topical 5-Aminosalicylates in Preventing Relapse of Quiescent Ulcerative Colitis: A Meta-analysis ALEXANDER C. FORD,*, KHURRAM J. KHAN,
More informationUlcerative Colitis: Refining our Management and Incorporating Newer Concepts
Ulcerative Colitis: Refining our Management and Incorporating Newer Concepts Asher Kornbluth, MD Clinical Professor of Medicine The Henry D. Janowitz The Mt. Sinai School of Medicine Refining our Management
More informationUpdate on Biologics in Ulcerative Colitis. Scott Plevy, MD University of North Carolina Chapel Hill, NC
Update on Biologics in Ulcerative Colitis Scott Plevy, MD University of North Carolina Chapel Hill, NC Objectives Discuss the latest advances in the pharmacologic management of ulcerative colitis Describe
More informationFOR UK NURSING MEDIA Embargoed until: 00:01 GMT, Friday 13 March 2015
Contact: Ross Selby Takeda UK Ltd Email ross.selby@takeda.com News Release FOR UK NURSING MEDIA Embargoed until: 00:01 GMT, Friday 13 March 2015 World s first gut-selective treatment for ulcerative colitis
More informationEndpoints for Stopping Treatment in UC
Endpoints for Stopping Treatment in UC Jana G. Hashash, MD Assistant Professor of Medicine Inflammatory Bowel Disease Center Division of Gastroenterology, Hepatology, and Nutrition University of Pittsburgh
More informationTacrolimus therapy as an alternativ Titlemaintaining remission in patients w colitis. Author(s) Yamamoto, Shuji; Nakase, Hiroshi; M Masuda, Satohiro; Inui, Ken-ichi; C Citation Journal of clinical gastroenterolog
More informationRelease of 5-Aminosalicylic Acid (5-ASA) from Mesalamine Formulations at Various ph Levels
Adv Ther (2015) 32:477 484 DOI 10.1007/s12325-015-0206-4 ORIGINAL RESEARCH Release of 5-Aminosalicylic Acid (5-ASA) from Mesalamine Formulations at Various ph Levels Adeyinka Abinusawa. Srini Tenjarla
More informationMedical Therapy for Pediatric IBD: Efficacy and Safety
Medical Therapy for Pediatric IBD: Efficacy and Safety Betsy Maxwell, MD Assistant Professor of Clinical Pediatrics Division of Gastroenterology, Hepatology, and Nutrition Pediatric IBD: Defining Remission
More informationDr. Elmer Schabel, MD. Bundesinstitut für Arzneimittel und Medizinprodukte, Bonn, Germany (No conflicts of interest)
EMA workshop on the development of new medicinal products for the treatment of ulcerative colitis and Crohn s disease Overview of authorised medicines for IBD in Europe - previous regulatory positions
More informationavailable at
Journal of Crohn's and Colitis (2009) 3, 32 37 available at www.sciencedirect.com An economic evaluation comparing once daily with twice daily mesalazine for maintaining remission based on results from
More informationDENOMINATOR: All patients aged 18 and older with a diagnosis of inflammatory bowel disease
Measure #270: Inflammatory Bowel Disease (IBD): Preventive Care: Corticosteroid Sparing Therapy National Quality Strategy Domain: Effective Clinical Care 2016 PQRS OPTIONS FOR INDIVIDUAL MEASURES: REGISTRY
More informationSevere IBD: What to Do When Anti- TNFs Don t Work?
Severe IBD: What to Do When Anti- TNFs Don t Work? David T. Rubin, MD, FACG Professor of Medicine Co-Director, Inflammatory Bowel Disease Center Interim Chief, Section of Gastroenterology, Hepatology and
More informationIBD Case Studies. David Rowbotham. Clinical Director & Consultant Gastroenterologist Dept of Gastroenterology & Hepatology Auckland City Hospital
IBD Case Studies David Rowbotham Clinical Director & Consultant Gastroenterologist Dept of Gastroenterology & Hepatology Auckland City Hospital Dr David Rowbotham The Leeds Teaching Hospitals NHS Trust
More informationDefinitions. Clinical remission: Resolution of symptoms (stool frequency 3/day, no bleeding and no urgency)
CROHN S DISEASE Definitions Clinical remission: Resolution of symptoms (stool frequency 3/day, no bleeding and no urgency) Recurrence: The reappearance of lesions after surgical resection Endoscopic remission:
More informationClinical Study Clinical Study of the Relation between Mucosal Healing and Long-Term Outcomes in Ulcerative Colitis
Hindawi Publishing Corporation Gastroenterology Research and Practice Volume 2013, Article ID 192794, 6 pages http://dx.doi.org/10.1155/2013/192794 Clinical Study Clinical Study of the Relation between
More informationThe following slides are provided as presented by the author during the live educa7onal ac7vity and are intended for reference purposes only.
The following slides are provided as presented by the author during the live educa7onal ac7vity and are intended for reference purposes only. If you have any ques7ons, please contact Imedex via email at:
More informationReview article: remission rates achievable by current therapies for inflammatory bowel disease
Alimentary Pharmacology and Therapeutics Review article: remission rates achievable by current therapies for inflammatory bowel disease L. Peyrin-Biroulet* & M. Lémann,1 *Inserm U954 and Department of
More informationΑναφορές εκβάσεων από τους ασθενείς (Patient Reported Outcomes): Μπορούν να αναβαθμίσουν τον τρόπο παρακολούθησης της νόσου; Γιώργος Μπάμιας
Αναφορές εκβάσεων από τους ασθενείς (Patient Reported Outcomes): Μπορούν να αναβαθμίσουν τον τρόπο παρακολούθησης της νόσου; Γιώργος Μπάμιας Σύγκρουση συμφερόντων Γιώργος Μπάμιας τιμητικές αμοιβές απο
More informationLiterature Review: CORE I & II: COlonic RElease Budesonide for the Induction of Remission for Mild- Moderate Ulcerative Colitis
VOLUME 13, ISSUE 1, YEAR 2014 Literature Review: CORE I & II: COlonic RElease Budesonide for the Induction of Remission for Mild- Moderate Ulcerative Colitis Peter R. McNally, DO, MACG, MSRF Center for
More informationDoncaster & Bassetlaw Medicines Formulary
Doncaster & Bassetlaw Medicines Formulary Section 1.5 Chronic Bowel Disorders (including IBD) Aminosalicylates: Mesalazine 400mg and 800mg MR Tablets (Octasa) Mesalazine 1.2g MR Tablets (Mezavant XL) Mesalazine
More informationMono or Combination Therapy with. Individualized Approach
Mono Combination Therapy with Biologics i in IBD: Developing an Individualized Approach David T. Rubin, MD, FACG Co-Direct, Inflammaty Bowel Disease Center Fellowship Program Direct University of Chicago
More informationFull title of guideline: Ulcerative colitis: the management of ulcerative colitis
Economic Plan This document identifies the priorities for economic analysis and the proposed methods for addressing these questions as described in section 7.1.3 of the Guidelines Manual (2009). 1 Guideline
More informationPrevalence of Nonadherence With Maintenance Mesalamine in Quiescent Ulcerative Colitis
THE AMERICAN JOURNAL OF GASTROENTEROLOGY Vol. 96, No. 10, 2001 2001 by Am. Coll. of Gastroenterology ISSN 0002-9270/01/$20.00 Published by Elsevier Science Inc. PII S0002-9270(01)03245-2 Prevalence of
More informationA Review of Delayed-Release MMX Mesalamine: It s Use in the Treatment of Ulcerative Colitis
A Review of Delayed-Release MMX Mesalamine: It s Use in the Treatment of Ulcerative Colitis Reem Sharaiha 1 and Arun Swaminath 2 REVIEW 1 Fellow, Division of Digestive and Liver Diseases, Columbia University
More informationAs clinicians we would all agree that the goal for our
CURRENT CONTROVERSIES: PRO, CON, AND BALANCE Controversies in Mucosal Healing in Ulcerative Colitis Sunanda Kane, MD,* Frances Lu, MD, Asher Kornbluth, MD, Dahlia Awais, MD, and Peter D.R. Higgins, MD,
More informationTitle: Author: Journal:
IMPORTANT COPYRIGHT NOTICE: This electronic article is provided to you by courtesy of Ferring Pharmaceuticals. The document is provided for personal usage only. Further reproduction and/or distribution
More informationWe review conventional therapies for ulcerative colitis
GASTROENTEROLOGY 2011;140:1827 1837 Conventional Medical Management of Inflammatory Bowel Disease Daniel Burger Simon Travis Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, United
More informationFistulizing Crohn s Disease: The Aggressive Approach
Fistulizing Crohn s Disease: The Aggressive Approach Bruce E. Sands, MD, MS MGH Crohn s and Colitis Center and Gastrointestinal Unit Massachusetts General Hospital Boston, USA Case Presentation: Summary
More informationIBD Updates. Themes in IBD IBD management journey. New tools for therapeutic monitoring. First-line treatment in IBD
IBD Updates Maria T. Abreu, MD University of Miami Miller School of Medicine Miami, Florida Themes in IBD 213 First-line treatment in IBD New tools for therapeutic monitoring Biologic therapy for CD and
More informationINTESTINAL DISEASE MEETING BERLIN Topical steroids rectal application
INTESTINAL DISEASE MEETING BERLIN 2006 Topical steroids rectal application Prof. Dr. med. T. Andus Department of Internal Medicine, Gastroenterology, Hepatology, and Oncology Krankenhaus Bad Cannstatt,
More informationAnti-tumour necrosis factor treatment of inflammatory bowel disease in liver transplant recipients
Alimentary Pharmacology and Therapeutics Anti-tumour necrosis factor treatment of inflammatory bowel disease in liver transplant recipients A. B. Mohabbat*, W. J. Sandborn, E. V. Loftus Jr, R. H. Wiesner
More informationMucosal healing: does it really matter?
Oxford Inflammatory Bowel Disease MasterClass Mucosal healing: does it really matter? Professor Jean-Frédéric Colombel, New York, USA Oxford Inflammatory Bowel Disease MasterClass Mucosal healing: does
More informationHow do I choose amongst medicines for inflammatory bowel disease. Maria T. Abreu, MD
How do I choose amongst medicines for inflammatory bowel disease Maria T. Abreu, MD Overview of IBD Pathogenesis Bacterial Products Moderately Acutely Inflamed Chronic Inflammation = IBD Normal Gut Mildly
More informationAchieving Success in Ulcerative Colitis: the Role of Infliximab
Achieving Success in Ulcerative Colitis: the Role of Infliximab Dr Gill Watermeyer IBD clinic Groote Schuur Hospital 17 th August 2012 Inflammatory Bowel Disease Crohn s disease and ulcerative colitis
More informationNew treatment options in IBD: today and the future. Silvio Danese Istituto Clinico Humanitas, Milan, Italy
New treatment options in IBD: today and the future Silvio Danese Istituto Clinico Humanitas, Milan, Italy Date of preparation: October 2014 GLO/EYV/2014-00010h Overview of the late-stage IBD drug pipeline*
More informationENTYVIO (VEDOLIZUMAB)
ENTYVIO (VEDOLIZUMAB) UnitedHealthcare Community Plan Medical Benefit Drug Policy Policy Number: CS2017D0053F Effective Date: July 1, 2017 Table of Contents Page INSTRUCTIONS FOR USE... 1 BENEFIT CONSIDERATIONS...
More informationTherapy for Inflammatory Bowel Disease
Therapy for Inflammatory Bowel Disease Jonathan P. Terdiman, MD Professor of Clinical Medicine Clinical Director, Center for Colitis and Crohn s Disease University of California San Francisco, CA UC: Current
More informationClinical Medicine Reviews in Therapeutics. Pharmacotherapy of Ulcerative Colitis: What Role for Mesalamine?
Clinical Medicine Reviews in Therapeutics R e v i e w Pharmacotherapy of Ulcerative Colitis: What Role for Mesalamine? Adam Harris 1, Mitul Patel 1 and Samir A. Shah 2 1 Warren Alpert School of Medicine
More informationLatest Treatment Updates for Ulcerative Colitis: Evolving Treatment Goals
Latest Treatment Updates for Ulcerative Colitis: Evolving Treatment Goals Stephen Hanauer, MD Professor of Medicine Medical Director, Digestive Disease Center Northwestern Medicine Chicago, Illinois Speaker
More informationConflict of Interest. Inflammatory Bowel Disease. Road Map. Scope of the Disorder (United States) Age-Specific Incidence of IBD*
Inflammatory Bowel Disease Conflict of Interest No conflicts of interest Sonia Friedman, M.D. Assistant Professor of Medicine Gastroenterology Division Brigham and Women s Hospital Road Map Background
More informationAminosalicylates. Giovanni Barbara. Department of Medical and Surgical Sciences Alma Mater Studiorum, University of Bologna, Italy ( )
Aminosalicylates Giovanni Barbara Department of Medical and Surgical Sciences Alma Mater Studiorum, University of Bologna, Italy (1088 2016) Colonic Diverticula, a Painless Ageing Change? 20% develop symptoms
More informationComplementary & Alternative Therapies in IBD
Complementary & Alternative Therapies in IBD Laurie Rosales, APRN-CNP OSU Wexner Medical Center Division of Gastroenterology, Hepatology and Nutrition Complementary & Alternative Probiotics Cannabis Fish
More informationSynopsis (C0168T37 ACT 1)
() Module 5.3 Protocol: CR004777 EudraCT No.: Not Applicable Title of the study: A Randomized, Placebo-controlled, Double-blind Trial to Evaluate the Safety and Efficacy of Infliximab in Patients with
More informationAnti tumor necrosis factor (TNF) agents have
Achieving Clinical Response and Remission in Moderate-to-Severe Ulcerative Colitis With Golimumab Sandborn WJ, Feagan BG, Marano C, et al; PURSUIT-SC Study Group. Subcutaneous golimumab induces clinical
More informationManaging IBD: Lessons I Have Learned Over the Past. Farraye s Tips
Managing IBD: Lessons I Have Learned Over the Past 25 Years Francis A. Farraye, MD, MSc Clinical Director Section of Gastroenterology Boston Medical Center Professor of Medicine Boston University School
More informationORIGINAL ARTICLE. Abstract. Introduction
ORIGINAL ARTICLE Annals of Gastroenterology (2014) 27, 1-5 Effectiveness of adalimumab for ambulatory ulcerative colitis patients after failure of infliximab treatment: a first real-life experience in
More informationUpdate on the management of ulcerative colitis: treatment and maintenance approaches focused on MMX mesalamine
Update on the management of ulcerative colitis: treatment and maintenance approaches focused on MMX mesalamine The Harvard community has made this article openly available. Please share how this access
More informationCan We Predict the Natural History of Ulcerative Colitis? Edward V Loftus, Jr, MD Professor of Medicine Mayo Clinic Rochester, Minnesota, USA
Can We Predict the Natural History of Ulcerative Colitis? Edward V Loftus, Jr, MD Professor of Medicine Mayo Clinic Rochester, Minnesota, USA Endpoints Overview Hospitalization Surgery Colorectal cancer
More informationEfficacy and Safety of Adalimumab in Ulcerative Colitis Refractory to Conventional Therapy in Routine Clinical Practice
Journal of Crohn's and Colitis, 216, 26 3 doi:1.193/ecco-jcc/jjv169 Advance Access publication September 21, 215 Original Article Original Article Efficacy and Safety of Adalimumab in Ulcerative Colitis
More informationMANAGING ULCERATIVE COLITIS: THE GUIDELINES AND BEYOND
MANAGING ULCERATIVE COLITIS: THE GUIDELINES AND BEYOND Mitchell RKL Lie, C Janneke van der Woude Department of Gastroenterology, Erasmus University Hospital, Rotterdam, the Netherlands Disclosure: No potential
More informationAzathioprine for Induction and Maintenance of Remission in Crohn s Disease
Azathioprine for Induction and Maintenance of Remission in Crohn s Disease William J. Sandborn, MD Chief, Division of Gastroenterology Director, UCSD IBD Center Objectives Azathioprine as induction and
More informationIBD :- a new era of diagnostics and therapy Dr Martyn Dibb Consultant Luminal Gastroenterologist Royal Liverpool University Hospital
IBD :- a new era of diagnostics and therapy Dr Martyn Dibb Consultant Luminal Gastroenterologist Royal Liverpool University Hospital Aims To understand the aetiology of IBD To understand the impact that
More information