Zachary M. Weil. EDUCATION Postdoctoral Fellow Rockefeller University (Donald W. Pfaff and Bruce S. McEwen)

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1 Curriculum Vita Research Assistant Professor Department of Neuroscience Ohio State University College of Medicine 704 Biomedical Research Tower 460 W. 12th Ave Columbus, OH EDUCATION Postdoctoral Fellow Rockefeller University (Donald W. Pfaff and Bruce S. McEwen) Doctor of Philosophy in Neuroscience Ohio State University (Randy J. Nelson) Bachelor of Science Ohio State University Graduation with honors, with distinction and cum laude RESEARCH INTERESTS Neuroendocrinology, neuroinflammation, animal models of cerebral ischemia, psychoneuroimmunology, autonomic and endocrine physiology, behavioral neuroscience, and evolutionary and comparative neuroscience. PUBLICATIONS McCartney H., Johnson A.D., Weil Z.M., and Givens, B. (2004). Theta reset produces optimal conditions for long-term potentiation. Hippocampus, 14: Pyter L.M., Weil Z.M., and Nelson R.J. (2005). Latitude affects photoperiod-induced changes in immune response in meadow voles (Microtus pennsylvanicus). Canadian Journal of Zoology, 83: Weil Z.M., Bowers S.L., Pyter L.M., and Nelson R.J. (2006). Social interactions alter proinflammatory cytokine gene expression and behavior following endotoxin administration. Brain, Behavior, and Immunity, 20: Weil Z.M., Hotchkiss A.K., Gatien M.L., Pieke-Dahl S., and Nelson R.J. (2006). Melatonin receptor (MT1) knockout mice display depression-like behaviors and deficits in sensorimotor gating. Brain Research Bulletin, 68: Benderlioglu Z., Eish J., Weil Z.M., and Nelson R.J. (2006). Low temperatures during early development influence subsequent maternal and reproductive function in adult female mice. Physiology & Behavior, 87:

2 Huang A.S., Beigneux A., Weil Z.M., Kim P.M., Molliver M.E., Blackshaw S., Young S.G., Nelson R.J., and Snyder S.H. (2006). D-Aspartate regulates melanocortin formation and function: behavioral alterations in D-aspartate oxidase deleted mice. The Journal of Neuroscience, 26: Weil Z.M., Bowers S.L., Dow E.R., and Nelson R.J. (2006). Maternal aggression persists following lipopolysaccharide-induced activation of the immune system. Physiology and Behavior, 87: Weil Z.M., Pyter L.M., Martin II L.B., and Nelson R.J. (2006). Early-life photoperiods organize adult immune responses in Siberian hamsters (Phodopus sungorus). American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 290: R1714-R1719. Weil Z.M., Huang A.S., Beigneux A., Kim P.M., Molliver M.E., Blackshaw S., Young S.G., Nelson R.J., and Snyder S.H. (2006). Behavioural alterations in male mice lacking the gene for D-aspartate oxidase. Behavioural Brain Research, 171: Martin II L.B., Weil Z.M., Kuhlman J.R., and Nelson R.J. (2006). Trade-offs between cutaneous immune responses in female white-footed mice (Peromyscus leucopus). Functional Ecology, 20: Weil Z.M., Martin II L.B., and Nelson R.J. (2006). Photoperiod differentially af fects immune function and reproduction in collared lemmings (Dicrostonyx groenlandicus). Journal of Biological Rhythms, 21: Weil Z.M., Martin II L.B., Workman J.L., and Nelson R.J. (2006). Immune challenge retards seasonal reproductive regression: evidence for terminal investment. Biology Letters, 2: Weil Z.M., Martin L.B., and Nelson, R.J. (2006). Interactions among immune, e ndocrine and behavioral response to infection. In: Morand S., Krasnov B.R. & Poulin R. (eds). Micromammals and Macroparasites: From Evolutionary Ecology to Management. Springer-Verlag, Berlin, pp Martin II L.B., Weil Z.M., and Nelson R.J. (2006). Refining approaches and diversifying directions in ecoimmunology. Integrative and Comparative Biology, 46: Martin II L.B., Navara K.J., Weil Z.M., and Nelson R.J. (2007). Maintenance of immunological memory is compromised by food restriction in male deer mice, Peromyscus maniculatus. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 290: R316-R320. Weil Z.M., Kidder S.L., and Nelson R.J. (2007). Photoperiod alters affective responses in collared lemmings. Behavioural Brain Research, 179:

3 Weil Z.M., Workman J.L., and Nelson R.J. (2007). Housing condition alters immunological and reproductive responses to day length in Siberian hamsters (Phodopus sungorus). Hormones and Behavior, 52: Martin II L.B., Weil Z.M., and Nelson, R.J. (2007). Immune defense and reproductive pace of life in deer mice. Ecology, 88: Martin II L.B., Weil Z.M., and Nelson R.J. (2008). Seasonal changes in vertebrate immune activity: mediation by physiological trade-offs. Philosophical Transactions of the Royal Society of London B: Biological Sciences, 363: Martin II L.B., Weil Z.M., and Nelson R.J. (2008). Fever and sickness behavior vary among congeneric rodents. Functional Ecology, 22: Workman J.L., Weil Z.M., Tuthill C.R., and Nelson R.J. (2008). Maternal pinealectomy increases depressive-like responses in Siberian hamster offspring. Behavioural Brain Research, 189: Martin II L.B., Weil Z.M., Bowers S.L., and Nelson R.J. (2008). Sex-specific effects of glucose deprivation on immunity and reproduction in Siberian hamsters (Phodopus sungorus). Journal of Comparative Physiology B, 178: Weil Z.M., Norman G., DeVries A.C., and Nelson R.J. (2008). The injured nervous system: A Darwinian perspective. Progress in Neurobiology, 86: Weil Z.M., Norman G., Barker J.M., Su A.J., Nelson R.J., and DeVries A.C. (2008). Social isolation potentiates cell death and inflammatory responses after global ischemia. Molecular Psychiatry, 13: Weil Z.M., Gatien-Hotchkiss M.L., and Nelson R.J. (2008). Photoperiod alters pain responsiveness via changes in pelage characteristics. The Canadian Journal of Zoology, 86: Weil Z.M., Norman G., DeVries A. C., Berntson G.G., and Nelson R.J. (2009). Photoperiod alters autonomic regulation of the heart. Proceedings of the National Academy of Sciences: 106: Weil Z.M., Norman G., Karelina K., Morris J., Barker J.M., Su, A.J., Walton J.C., Bohinc S., Nelson R.J., and DeVries A.C. (2009). Sleep deprivation attenuates inflammatory responses and ischemic cell death. Experimental Neurology: 218: Fonken K.L., Finy S.M., Walton J.C., Weil Z.M., Workman J.L., Ross J., and Nelson R.J. (2009). Influence of light at night on murine anxiety- and depressive-like responses. Behavioural Brain Research: 205:

4 Weil Z.M., Karelina K., Su A.J., Barker J.M., Norman G.J., Zhang N., DeVries A.C., and Nelson R.J. (2009). Time-of-day determines neuronal damage and mortality after cardiac arrest. Neurobiology of Disease: 36: Weil Z.M. and Crews D. Photoperiodism in amphibians and reptiles. (2010). In Nelson R.J., Denlinger D.L., and Somers D.E., (eds) Photoperiod: The Biological Calendar. Oxford University Press, pp Demas G.E., Weil Z.M., and Nelson R.J. Photoperiodism in mammals: non-reproductivetraits. (2010). In Nelson R.J., Denlinger D.L., and Somers D.E., (eds) Photoperiod: The Biological Calendar. Oxford University Press, pp Weil Z.M., Zhang Q., Hornung A., Blizard D., and Pfaff D.W. (2010). Impact of generalized brain arousal on sexual Behavior. Proceedings of the National Academy of Sciences: 107: Bailey M.T., Walton J.C., Dowd S.E., Weil Z.M., and Nelson R.J. (2010). Photoperiod modulates gut bacteria composition. Brain, Behavior and Immunity: 24: Karatsoreos I.N., Bhagat S.M., Weil Z.M., Pfaff D.W., and McEwen B.S. (2010). Chronic corticosterone treatment results in physiological and behavioral changes mimicking the metabolic syndrome. Endocrinology: 151: Weil Z.M., Murakami G., and Pfaff D.W. (2010). Reproductive behaviors: New developments in concepts and in molecular mechanisms. In Martini, L. Neuroendocrinology: The Normal Neuroendocrine System. Progress in Brain Research. 181: Karelina K., Walton J.C., Weil Z.M., Norman G., Nelson R.J., and Devries A.C. (2010). Estrous phase alters social behavior in a polygynous but not a monogamous Peromyscus species. Hormones and Behavior. 58: Weil, Z.M. and Nelson, R.J. (In Press). Neuroendocrine mechanisms of seasonal changes in immune function. In Demas, G.E. & Nelson, R.J. (editors). Eco-Immunology. Oxford University Press: New York. Weil Z.M., Workman J.L., Karelina K., and Nelson R.J. (submitted). Short photoperiods alter cannabinoid receptor expression in hypothalamic nuclei related to energy balance. Glaser R., Yang E.V., Chen M., Weil Z.M., Nelson R.J., Lo K.W., Kozak, C. (submitted). A protocol describing a SCID mouse model for studying Epstein-Barr Virus replication in nasopharyngeal carcinoma tumor. Gagnidze K., Weil Z.M., and Pfaff D.W. (submitted). New hypothesis for sexual differentiation of brain and behavior.

5 Weil Z.M., Ribeiro A.C., Shyteler A., Li J.D., Zhou, Q.Y., and Pfaff D.W. (submitted). Sexual behavior deficits in prokineticin 2 deficient mice. PUBLISHED ABSTRACTS Weil Z.M., Hunter R.G., McEwen B.S., Allis C., and Pfaff D.W. (2009). Estrogenic regulation of histone acetylation in ventromedial hypothalamic neurons. Chicago, Illinois: Society for Neuroscience. Pfaff D.W., Zhang Q., Blizard D., Shelley D.N., Weil Z.M. (2009). Male sex behavior in mice selected for high or low generalized CNS arousal. Chicago, Illinois: Society for Neuroscience. Fonken L.M., Finy M.S., Walton J.C., Weil Z.M., Workman J.L., Ross J., Nelson R.J. (2009). Influence of light-at-night on murine anxiety- and depressive-like responses. Chicago, Illinois: Society for Neuroscience. Weil Z.M., Nelson R.J., and Devries A.C. (2009). Seasonal and circadian determinants of cardiovascular disease. East Lansing, Michigan: Society for Behavioral Neuroendocrinology. Karelina K., Walton J.C., Weil Z.M., Norman G.J., Wells J.S., and DeVries A.C. (2009). Oxytocin and ovarian hormones mediate social behavior in Peromyscus leucopus. East Lansing, Michigan: Society for Behavioral Neuroendocrinology. Walton J.C., Weil Z.M., and Nelson R.J. (2009). The effect of constant light on immune function and wound healing in Siberian hamsters (Phodopus sungorus). East Lansing, Michigan: Society for Behavioral Neuroendocrinology. Weil Z.M., Su A.J., Barker J.M., Karelina K., Norman G., Nelson R.J., and DeVries A.C. (2008). Melatonin and circadian variation in global ischemia. Washington, DC: Society for Neuroscience. Norman G.J., Berntson G.G., Weil Z.M., Zhang N., Karelina K., Morris J.S., Al-Abed Y., Pavlov V.A., Tracey K.J., and DeVries, A.C. (2008). Cholinergic regulation of inflammation following global ischemia. Washington, DC: Society for Neuroscience. Jessen T.N., Carneiro A.M.D, Weil Z.M., Nelson R.J., and Blakely R.D. (2008). Environmentally induced regulation of the serotonin transporter? Washington, DC: Society for Neuroscience. Weil Z.M. Trainor B.C., Nelson R.J., and DeVries A.C. (2007). Photoperiod alters cardiac arrest outcome. Asilomar, California: Society for Behavioral Neuroendocrinology.

6 Weil Z.M., Su A., Nelson R.J., and DeVries A.C. (2007). Circadian variation in global ischemia outcomes. San Diego, California: Society for Neuroscience. Weil Z.M. and Nelson R.J. (2006). Photoperiod alters affective behaviors in Collared lemmings (Dicrostonyx groenlandicus). Atlanta, Georgia: Society for Neuroscience. Weil Z.M., Bowers S.L., Pyter L.M. and Nelson R.J. (2006). Persistent alterations in behavior and immune function after sexual experience. Pittsburgh, Pennsylvania: Society for Behavioral Neuroendocrinology. Weil Z.M., Bowers S.L., and Nelson R.J. (2005). Lipopolysaccharide inhibits maternal aggression. Washington, DC: Society for Neuroscience. Weil Z.M., Bowers S.L., Pyter L.M., and Nelson R.J. (2005). Social interactions alter proinflammatory cytokine gene expression and behavior following endotoxin administration. Austin, Texas: Society for Behavioral Neuroendocrinology. Weil Z.M., and Nelson R.J. (2005). Social interactions alter proinflammatory cytokine gene expression and behavior following endotoxin administration. Columbus, OH: Hayes Graduate Research Forum. Martin L.B., Hotchkiss A.K., Weil Z.M., and Nelson R.J. (2005). Fitness costs of induced immune activity in Siberian hamsters. San Diego, CA: Society for Integrative and Comparative Biology. Weil Z.M., Benderlioglu Z., and Nelson R.J. (2005). Low temperatures during early development affect adult behavior in mice. San Diego, California: Society for Neuroscience. McCartney H., Johnson A., Weil Z.M., Tabbah R., and Givens B. (2002). Theta reset produces optimal conditions for long-term potentiation in the dentate gyrus. Orlando Florida: Society for Neuroscience. JOURNAL REVIEWER American Journal of Physiology: Regulatory, Integrative and Comparative Physiology The American Naturalist Behavioural Processes Behavioral Neuroscience Brain, Behavior and Immunity Brain Research Chronobiology International Clinical Medicine: Endocrinology and Diabetes International Journal of Experimental Pathology Experimental Neurology Frontiers in Neuroendocrinology

7 Hormones and Behavior Journal of Biological Rhythms Journal of Cerebral Blood Flow and Metabolism Journal of Comparative Physiology (B) Journal of Pineal Research Journal of Neuroscience Mammalia Molecular Psychiatry Physiology and Behavior Psychoneuroendocrinology Proceedings of the Royal Society of London B: Biological Sciences Proceedings of the National Academy of Sciences: USA Reproduction, Fertility and Development Science Stroke Zoology Zachary M. Weil PROFESSIONAL SERVICE Ohio State Interdisciplinary Graduate Programs, Molecular Life Sciences Research Forum, Planning Committee ( ). Society for Behavioral Neuroendocrinology, Education Committee ( ). Junior Faculty Member, Faculty of 1000 Biology. HONORS AND AWARDS University Honors and Scholars Delegate to Sao Paolo Research Exchange Program, The Ohio State University, Denman Undergraduate Research Forum, Winner for Social and Behavioral Sciences, Society for Neuroscience, Graduate Student Travel Award, November, Society for Behavioral Endocrinology, Best Poster Award, June Society for Behavioral Neuroendocrinology, NSF Young Investigator Award, June FINANCIAL SUPPORT University Fellow, Ohio State University, September, Ohio State Sigma Xi Chapter Grants-in-Aid of Research Recipient, National Sigma Xi Grants-in-Aid of Research Recipient, Spring, Predoctoral Fellowship, The American Heart Association, July, (declined). Mary S. Muellhaupt Presidential Predoctoral Fellowship, Ohio State University, June, Postdoctoral Fellowship. NIH T32 DK Tri-institutional Endocrine Research Training Program, June 2009-May INVITED SEMINARS University of California Berkeley, Department of Psychology

8 Rockefeller University, Laboratory of Neuroendocrinology Michigan State University, Department of Psychology Society for Behavioral Neuroendocrinology, Young Investigator Symposium Ohio State University, Department of Neuroscience Zachary M. Weil OTHER TRAINING New England Biolabs/Smith College Summer Molecular Biology Training Course PROFESSIONAL MEMBERSHIP The Society for Neuroscience The Society for Behavioral Neuroendocrinology The American Heart Association The American Physiological Society Sigma Xi AAAS New York Academy of Sciences Teaching Experience Biological Clocks and Behavior Med 1 Neural Sciences Biology of Aggression Behavioral Endocrinology